Biography
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Hematology (2019)
- Fellowship: Stanford University School of Medicine (1987) CA
- Residency: Stanford University School of Medicine (1986) CA
- Internship: Stanford University School of Medicine (1985) CA
- Board Certification: American Board of Internal Medicine, Internal Medicine (1987)
- Medical Education: Harvard Medical School (1984) MA
- BA, Univ. California, Berkeley, Biochemistry (1977)
Honors & Awards
- Associate Editor, Blood (2010-2017)
- Distinguished Clinical Scientist Award, Doris Duke Foundation (2004-2009)
- Fellow, Jose Carreras International Leukemia Foundation (1993-1996)
- Fellowship, Damon Runyon-Walter Winchell Cancer Fund (1988-1991)
- Member, Association of American Physicians (AAP) (2008)
- President, American Society of Blood and Marrow Transplantation (2006-2007)
- President, International Society of Cellular Therapy (2000-2002)
Memberships
- Member, American Society of Hematology
- Editor in Chief, Blood Advances (2017 - Present)
- Member, International Society of Experimental Hematology
- Member, American College of Physicians
- Member, American Association for the Advancement of Science
- Member, International Society for Cellular Therapy
- Member, American Society for Blood and Marrow Transplantation
Administrative Appointments
- Division Chief, Blood and Marrow Transplant Program, Stanford University (2000 - 2020)
- Medical Director, Clinical Bone Marrow Transplantation Laboratory (1990 - 2011)
Publications
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Engraftment of chronic myeloid leukemia in SCID mice
Hoyle, C. F., & Negrin, R. S. (1998). Engraftment of chronic myeloid leukemia in SCID mice. HEMATOLOGICAL ONCOLOGY, 16(3), 87–100. -
Visualizing the kinetics of tumor-cell clearance in living animals
Sweeney, T. J., Mailander, V., Tucker, A. A., Olomu, A. B., Zhang, W. S., Cao, Y. A., … Contag, C. H. (1999). Visualizing the kinetics of tumor-cell clearance in living animals. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(21), 12044–49. -
Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival.
Ross, M., Schmidt, G. M., Niland, J. C., Amylon, M. D., Dagis, A. C., Long, G. D., … Chao, N. J. (1999). Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival. Biology of Blood and Marrow Transplantation , 5(5), 285–91. -
Impact of admission body weight and chemotherapy dose adjustment on the outcome of autologous bone marrow transplantation.
Dickson, T. M., Kusnierz-Glaz, C. R., Blume, K. G., Negrin, R. S., Hu, W. W., Shizuru, J. A., … Stockerl-Goldstein, K. E. (1999). Impact of admission body weight and chemotherapy dose adjustment on the outcome of autologous bone marrow transplantation. Biology of Blood and Marrow Transplantation , 5(5), 299–305. -
A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer
Hu, W. W., Long, G. D., Stockerl-Goldstein, K. E., JOHNSTON, L. J., Chao, N. J., Negrin, R. S., & Blume, K. G. (1999). A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer. CLINICAL CANCER RESEARCH, 5(11), 3411–3418. -
Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission
Snyder, D. S., Nademanee, A. P., O'Donnell, M. R., Parker, P. M., Stein, A. S., Margolin, K., … Forman, S. J. (1999). Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission. LEUKEMIA, 13(12), 2053–2058. -
Four-cycle high-dose therapy with hematopoietic support for metastatic breast cancer: No improvement in outcomes compared with single-course high-dose therapy
Hu, W. W., Negrin, R. S., Stockerl-Goldstein, K., JOHNSTON, L. J., Shizuru, J. A., Wong, R. M., … Blume, K. G. (2000). Four-cycle high-dose therapy with hematopoietic support for metastatic breast cancer: No improvement in outcomes compared with single-course high-dose therapy. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(1), 58–69. -
Effect of oral glutamine supplementation during bone marrow transplantation
Dickson, T. M. C., Wong, R. M., Negrin, R. S., Shizuru, J. A., JOHNSTON, L. J., Hu, W. W., … Stockerl-Goldstein, K. E. (2000). Effect of oral glutamine supplementation during bone marrow transplantation. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 24(2), 61–66. -
Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: Results of a prospective double-blind randomized trial
Chao, N. J., Snyder, D. S., Jain, M., Wong, R. M., Niland, J. C., Negrin, R. S., … Blume, K. G. (2000). Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: Results of a prospective double-blind randomized trial. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(3), 254–261. -
Transplantation of highly purified CD34(+)Thy-I+ hematopoietic stem cells in patients with metastatic breast cancer
Negrin, R. S., Atkinson, K., Leemhuis, T., Hanania, E., Juttner, C., Tierney, K., … Klein, J. (2000). Transplantation of highly purified CD34(+)Thy-I+ hematopoietic stem cells in patients with metastatic breast cancer. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(3), 262–71. -
High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma
Alvarnas, J. C., Negrin, R. S., Horning, S. J., Hu, W. W., Long, G. D., Schriber, J. R., … Chao, N. J. (2000). High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(3A), 352–58. -
Pulmonary toxicity syndrome in breast cancer patients undergoing BCNU-containing high-dose chemotherapy and autologous hematopoietic cell transplantation
Cao, T. M., Negrin, R. S., Stockerl-Goldstein, K. E., JOHNSTON, L. J., Shizuru, J. A., Taylor, T. L., … Hu, W. W. (2000). Pulmonary toxicity syndrome in breast cancer patients undergoing BCNU-containing high-dose chemotherapy and autologous hematopoietic cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(4), 387–94. -
Use of reporter genes for optical measurements of neoplastic disease in vivo
Contag, C. H., Jenkins, D., Contag, F. R., & Negrin, R. S. (2000). Use of reporter genes for optical measurements of neoplastic disease in vivo. NEOPLASIA, 2(1-2), 41–52. -
Noninvasive assessment of tumor cell proliferation in animal models.
Edinger, M., Sweeney, T. J., Tucker, A. A., Olomu, A. B., Negrin, R. S., & Contag, C. H. (1999). Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia , 1(4), 303–10. -
Resistance of ex vivo expanded CD3(+)CD56(+) T cells to Fas-mediated apoptosis
Verneris, M. R., Kornacker, M., Mailander, V., & Negrin, R. S. (2000). Resistance of ex vivo expanded CD3(+)CD56(+) T cells to Fas-mediated apoptosis. CANCER IMMUNOLOGY IMMUNOTHERAPY, 49(6), 335–45. -
Favorable treatment outcome in non-Hodgkin's lymphoma patients with "poor" mobilization of peripheral blood progenitor cells
Stockerl-Goldstein, K. E., Reddy, S. A., Horning, S. J., Blume, K. G., Chao, N. J., Hu, W. W., … Negrin, R. S. (2000). Favorable treatment outcome in non-Hodgkin's lymphoma patients with "poor" mobilization of peripheral blood progenitor cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(5), 506–12. -
Toxicity of high-dose sequential chemotherapy and purged autologous hematopoietic tell transplantation precludes its use in refractory/recurrent non-Hodgkin's lymphoma
Johnston, L. J., Stockerl-Goldstein, K. E., Hu, W. W., Negrin, R. S., Hoppe, R. T., Blume, K. G., & Horning, S. J. (2000). Toxicity of high-dose sequential chemotherapy and purged autologous hematopoietic tell transplantation precludes its use in refractory/recurrent non-Hodgkin's lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(5A), 555–562. -
CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies
Lopez, R. D., Xu, S., Guo, B., Negrin, R. S., & Waller, E. K. (2000). CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies. BLOOD, 96(12), 3827–37. -
High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial
Horning, S. J., Negrin, R. S., Hoppe, R. T., Rosenberg, S. A., Chao, N. J., Long, G. D., … Blume, K. G. (2001). High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial. BLOOD, 97(2), 404–9. -
Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells
Kornacker, M., Verneris, M. R., Kornacker, B., Scheffold, C., & Negrin, R. S. (2001). Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells. IMMUNOLOGY LETTERS, 76(3), 169–73. -
Expansion of cytolytic CD8(+) natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon gamma production
Baker, J., Verneris, M. R., Ito, M., Shizuru, J. A., & Negrin, R. S. (2001). Expansion of cytolytic CD8(+) natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon gamma production. BLOOD, 97(10), 2923–31. -
Expansion of cytotoxic CD3(+)CD56(+) cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation
Alvarnas, J. C., Linn, Y. C., Hope, E. G., & Negrin, R. S. (2001). Expansion of cytotoxic CD3(+)CD56(+) cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 7(4), 216–22. -
High-dose therapy and autologous hematopoietic-cell transplantation for follicular lymphoma beyond first remission: The Stanford University experience
Cao, T. M., Horning, S. F., Negrin, R. S., Hu, W. W., Johnston, L. F., Taylor, T. L., … Stockerl-Goldstein, K. (2001). High-dose therapy and autologous hematopoietic-cell transplantation for follicular lymphoma beyond first remission: The Stanford University experience. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 7(5), 294–301. -
Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+cells in patients with advanced hematologic malignancies
Cao, T. M., Kusnierz-Glaz, C., Valone, F., Stockerl-Goldstein, K. E., Hu, W. W., Johnston, L., … Negrin, R. S. (2001). Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+cells in patients with advanced hematologic malignancies. CANCER, 91(12), 2205–13. -
CD31 mismatching affects marrow transplantation outcome
GRUMET, F. C., Hiraki, D. D., Brown, B. W., Zehnder, J. L., Zacks, E. S., Draksharapu, A., … Negrin, R. S. (2001). CD31 mismatching affects marrow transplantation outcome. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 7(9), 503–12. -
Bioluminescence imaging of lymphocyte trafficking in vivo
Hardy, J., Edinger, M., Bachmann, M. H., Negrin, R. S., Fathman, C. G., & Contag, C. H. (2001). Bioluminescence imaging of lymphocyte trafficking in vivo. EXPERIMENTAL HEMATOLOGY, 29(12), 1353–60. -
Engineering hematopoietic grafts: Purified allogeneic hematopoietic stem cells plus expanded CD8(+) NK-T cells in the treatment of lymphoma
Verneris, M. R., Ito, M., Baker, E., Arshi, A., Negrin, R. S., & Shizuru, J. A. (2001). Engineering hematopoietic grafts: Purified allogeneic hematopoietic stem cells plus expanded CD8(+) NK-T cells in the treatment of lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 7(10), 532–42. -
Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease
Stuart, M. J., Chao, N. S., Horning, S. J., Wong, R. M., Negrin, R. S., JOHNSTON, L. J., … Goldstein, S. (2001). Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 7(10), 552–60. -
Studies of ex vivo activated and expanded CD8(+) NK-T cells in humans and mice
Verneris, M. R., Baker, J., Edinger, M., & Negrin, R. S. (2002). Studies of ex vivo activated and expanded CD8(+) NK-T cells in humans and mice. JOURNAL OF CLINICAL IMMUNOLOGY, 22(3), 131–36. -
Visualization of effective tumor targeting by CD8+natural killer T cells redirected with bispecific antibody F(ab ')(2)HER2xCD3
Scheffold, C., Kornacker, M., Scheffold, Y. C., Contag, C. H., & Negrin, R. S. (2002). Visualization of effective tumor targeting by CD8+natural killer T cells redirected with bispecific antibody F(ab ')(2)HER2xCD3. CANCER RESEARCH, 62(20), 5785–91. -
Advancing animal models of neoplasia through in vivo bioluminescence imaging
Edinger, M., Cao, Y. A., Hornig, Y. S., Jenkins, D. E., Verneris, M. R., Bachmann, M. H., … Contag, C. H. (2002). Advancing animal models of neoplasia through in vivo bioluminescence imaging. EUROPEAN JOURNAL OF CANCER, 38(16), 2128–36. -
Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging
Edinger, M., Cao, Y. A., Verneris, M. R., Bachmann, M. H., Contag, C. H., & Negrin, R. S. (2003). Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. BLOOD, 101(2), 640–48. -
Understanding immune cell trafficking patterns via in vivo bioluminescence imaging
Mandl, S., Schimmelpfennig, C., Edinger, M., Negrin, R. S., & Contag, C. H. (2002). Understanding immune cell trafficking patterns via in vivo bioluminescence imaging. JOURNAL OF CELLULAR BIOCHEMISTRY, 239–48. -
Visualization of tumor growth and response to NK-T cell based immunotherapy using bioluminescence
Negrin, R. S., Edinger, M., Verneris, M., Cao, Y. A., Bachmann, M., & Contag, C. H. (2002). Visualization of tumor growth and response to NK-T cell based immunotherapy using bioluminescence. Presented at the 3rd International Symposium on Transplantation in Hematology and Oncology, MUNSTER,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY,GERMANY: SPRINGER. -
CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
Edinger, M., Hoffmann, P., Ermann, J., Drago, K., Fathman, C. G., Strober, S., & Negrin, R. S. (2003). CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. NATURE MEDICINE, 9(9), 1144–50. -
Use of the polymerase chain reaction for the detection of tumor cell involvement of bone marrow and peripheral blood: implications for purging.
Negrin, R. S. (1992). Use of the polymerase chain reaction for the detection of tumor cell involvement of bone marrow and peripheral blood: implications for purging. Journal of Hematotherapy, 1(4), 361–368. -
THE USE OF COLONY STIMULATING FACTORS IN CLINICAL BONE-MARROW TRANSPLANTATION
Negrin, R. S., & Greenberg, P. L. (1992). THE USE OF COLONY STIMULATING FACTORS IN CLINICAL BONE-MARROW TRANSPLANTATION. CURRENT OPINION IN IMMUNOLOGY, 4(5), 567–70. -
Therapy of hematopoietic disorders with recombinant colony-stimulating factors.
Negrin, R. S., & Greenberg, P. L. (1992). Therapy of hematopoietic disorders with recombinant colony-stimulating factors. Advances in Pharmacology (San Diego, Calif.), 23, 263–96. -
Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system
Shizuru, J. A., Negrin, R. S., & Weissman, I. L. (2005). Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system. ANNUAL REVIEW OF MEDICINE, 56, 509–38. -
A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma
Leemhuis, T., Wells, S., Scheffold, C., Edinger, M., & Negrin, R. S. (2005). A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 11(3), 181–87. -
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets
Beilhack, A., Schulz, S., Baker, J., Beilhack, G. F., Wieland, C. B., Herman, E. I., … Negrin, R. S. (2005). In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. BLOOD, 106(3), 1113–22. -
Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells
Verneris, M. R., Arshi, A., Edinger, M., Kornacker, M., Natkunam, Y., Karami, M., … Negrin, R. S. (2005). Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells. CLINICAL CANCER RESEARCH, 11(12), 4561–70. -
Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation
Cao, Y. A., Bachmann, M. H., Beilhack, A., Yang, Y., Tanaka, M., Swijnenburg, R. J., … Contag, C. H. (2005). Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. TRANSPLANTATION, 80(1), 134–39. -
Protective conditioning for acute graft-versus-host disease
Lowsky, R., Takahashi, T., Liu, Y. P., Dejbakhsh-Jones, S., GRUMET, F. C., Shizuru, J. A., … Strober, S. (2005). Protective conditioning for acute graft-versus-host disease. NEW ENGLAND JOURNAL OF MEDICINE, 353(13), 1321–31. -
Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation
Schimmelpfennig, C. H., Schulz, S., Arber, C., Baker, J., Tarner, I., McBride, J., … Negrin, R. S. (2005). Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation. AMERICAN JOURNAL OF PATHOLOGY, 167(5), 1321–31. -
Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8(+) T cells and NK cells
Karimi, M., Cao, T. M., Baker, J. A., Verneris, M. R., Soares, L., & Negrin, R. S. (2005). Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8(+) T cells and NK cells. JOURNAL OF IMMUNOLOGY, 175(12), 7819–28. -
DYNAMIC ASSESSMENT OF QUALITY-OF-LIFE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION
Chao, N. J., Tierney, D. K., Bloom, J. R., Long, G. D., Barr, T. A., STALLBAUM, B. A., … Blume, K. G. (1992). DYNAMIC ASSESSMENT OF QUALITY-OF-LIFE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION. BLOOD, 80(3), 825–30. -
Inhibition of CD4(+)CD25(+) regulatory T-cell function by calcineurin-dependent interleukin-2 production
Zeiser, R., Nguyen, V. H., Beilhack, A., Buess, M., Schulz, S., Baker, J., … Negrin, R. S. (2006). Inhibition of CD4(+)CD25(+) regulatory T-cell function by calcineurin-dependent interleukin-2 production. BLOOD, 108(1), 390–99. -
Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: A preclinical study
Chan, J. K., Hamilton, C. A., Cheung, M. K., Karimi, M., Baker, J., Gall, J. M., … Negrin, R. S. (2006). Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: A preclinical study. CLINICAL CANCER RESEARCH, 12(6), 1859–67. -
Synergistic antitumor effects of immune cell-viral biotherapy
Thorne, S. H., Negrin, R. S., & Contag, C. H. (2006). Synergistic antitumor effects of immune cell-viral biotherapy. SCIENCE, 311(5768), 1780–84. -
In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease.
Negrin, R. S., & Contag, C. H. (2006). In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease. Nature Reviews. Immunology, 6(6), 484–90. -
High-dose carmustine, etoposide, and cyclophosphamide followed by allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma
Law, L. Y., Horning, S. J., Wong, R. M., Johnston, L. J., Laport, G. G., Lowsky, R., … Stockerl-Goldstein, K. E. (2006). High-dose carmustine, etoposide, and cyclophosphamide followed by allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 12(7), 703–11. -
EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR AND GRANULOCYTE-MONOCYTE COLONY STIMULATING FACTOR ON INVITRO HEMATOPOIESIS IN THE MYELODYSPLASTIC SYNDROMES
Nagler, A., Ginzton, N., Negrin, R., Bang, D., Donlon, T., & Greenberg, P. (1990). EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR AND GRANULOCYTE-MONOCYTE COLONY STIMULATING FACTOR ON INVITRO HEMATOPOIESIS IN THE MYELODYSPLASTIC SYNDROMES. LEUKEMIA, 4(3), 193–202. -
EFFECTS OF PROLONGED TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR
Greenberg, P., Negrin, R., Nagler, A., Vincent, M., & Donlon, T. (1990). EFFECTS OF PROLONGED TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR. Presented at the 2ND INTERNATIONAL CONF ON BLOOD CELL GROWTH FACTORS : THEIR BIOLOGY AND CLINICAL APPLICATIONS, CAPRI,ITALY,ITALY,ITALY: ALPHAMED PRESS. -
EFFECTS OF TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR
Greenberg, P., Negrin, R., Nagler, A., Souza, L., & Donlon, T. (1990). EFFECTS OF TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR. Presented at the 20TH ANNUAL SCIENTIFIC SYMP OF THE AMERICAN RED CROSS, BETHESDA,MD,MD,MD: WILEY-LISS, INC. -
MAINTENANCE TREATMENT OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES USING RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR
Negrin, R. S., HAEUBER, D. H., Nagler, A., Kobayashi, Y., Sklar, J., Donlon, T., … Greenberg, P. L. (1990). MAINTENANCE TREATMENT OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES USING RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR. BLOOD, 76(1), 36–43. -
EFFECTS OF CSFS IN PRELEUKEMIA
Greenberg, P. L., Negrin, R., & Nagler, A. (1990). EFFECTS OF CSFS IN PRELEUKEMIA. Presented at the 3RD INTERNATIONAL SYMP ON MINIMAL RESIDUAL DISEASE IN ACUTE LEUKEMIA, ROTTERDAM,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS,NETHERLANDS: STOCKTON PRESS. -
IMPACT OF MARROW CYTOGENETICS AND MORPHOLOGY ON INVITRO HEMATOPOIESIS IN THE MYELODYSPLASTIC SYNDROMES - COMPARISON BETWEEN RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (CSF) AND GRANULOCYTE-MONOCYTE CSF
Nagler, A., Binet, C., MacKichan, M. L., Negrin, R., Bangs, C., Donlon, T., & Greenberg, P. (1990). IMPACT OF MARROW CYTOGENETICS AND MORPHOLOGY ON INVITRO HEMATOPOIESIS IN THE MYELODYSPLASTIC SYNDROMES - COMPARISON BETWEEN RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (CSF) AND GRANULOCYTE-MONOCYTE CSF. BLOOD, 76(7), 1299–1307. -
Early CD30 signaling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells in prevention of acute graft-versus-host disease
Zeiser, R., Nguyen, V. H., Hou, J.-Z., Beilhack, A., Zambricki, E., Buess, M., … Negrin, R. S. (2007). Early CD30 signaling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells in prevention of acute graft-versus-host disease. BLOOD, 109(5), 2225–33. -
Role of naturally arising regulatory T cells in hematopoietic cell transplantation
Nguyen, V. H., Zeiser, R., & Negrin, R. S. (2006). Role of naturally arising regulatory T cells in hematopoietic cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 12(10), 995–1009. -
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Nguyen, V. H., Zeiser, R., daSilva, D. L., Chang, D. S., Beilhack, A., Contag, C. H., & Negrin, R. S. (2007). In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. BLOOD, 109(6), 2649–56. -
USE OF A SCID MOUSE HUMAN LYMPHOMA MODEL TO EVALUATE CYTOKINE-INDUCED KILLER-CELLS WITH POTENT ANTITUMOR CELL-ACTIVITY
SCHMIDTWOLF, I. G. H., Negrin, R. S., Kiem, H. P., Blume, K. G., & Weissman, I. L. (1991). USE OF A SCID MOUSE HUMAN LYMPHOMA MODEL TO EVALUATE CYTOKINE-INDUCED KILLER-CELLS WITH POTENT ANTITUMOR CELL-ACTIVITY. JOURNAL OF EXPERIMENTAL MEDICINE, 174(1), 139–149. -
INVITRO AND INVIVO ACTIVITY OF MURINE LYMPHOKINE-ACTIVATED KILLER-CELLS AFTER CRYOPRESERVATION
SCHMIDTWOLF, I. G. H., Aihara, M., Negrin, R. S., Blume, K. G., & Chao, N. J. (1992). INVITRO AND INVIVO ACTIVITY OF MURINE LYMPHOKINE-ACTIVATED KILLER-CELLS AFTER CRYOPRESERVATION. TRANSFUSION, 32(1), 42–45. -
CD101 surface expression discriminates potency among murine FoxP3(+) regulatory T cells
Fernandez, I., Zeiser, R., Karsunky, H., Kambham, N., Beilhack, A., Soderstrom, K., … Engleman, E. (2007). CD101 surface expression discriminates potency among murine FoxP3(+) regulatory T cells. JOURNAL OF IMMUNOLOGY, 179(5), 2808–14. -
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity
Zeiser, R., Youssef, S., Baker, J., Kambham, N., Steinman, L., & Negrin, R. S. (2007). Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. BLOOD, 110(13), 4588–98. -
The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation
Nguyen, V. H., Shashidhar, S., Chang, D. S., Ho, L., Kambham, N., Bachmann, M., … Negrin, R. S. (2008). The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation. BLOOD, 111(2), 945–53. -
Differential impact of mammalian target of rapamycin inhibition on CD4(+)CD25(+)Foxp3(+) regulatory T cells compared with conventional CD4(+) T cells
Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., Kambham, N., Beilhack, A., Loh, J., … Negrin, R. S. (2008). Differential impact of mammalian target of rapamycin inhibition on CD4(+)CD25(+)Foxp3(+) regulatory T cells compared with conventional CD4(+) T cells. BLOOD, 111(1), 453–62. -
A novel technique for the enrichment of primary ovarian cancer cells
Chan, J. K., Hamilton, C. A., Anderson, E. M., Cheung, M. K., Baker, J., Husain, A., … Negrin, R. S. (2007). A novel technique for the enrichment of primary ovarian cancer cells. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 197(5). -
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs
Beilhack, A., Schulz, S., Baker, J., Beilhack, G. F., Nishimura, R., Baker, E. M., … Negrin, R. S. (2008). Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. BLOOD, 111(5), 2919–28. -
Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease
Zeiser, R., Zambricki, E. A., Leveson-Gower, D., Kambham, N., Beilhack, A., & Negrin, R. S. (2007). Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 13(12), 1427–38. -
Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation.
Zeiser, R., Beilhack, A., & Negrin, R. S. (2006). Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation. Current Stem Cell Research & Therapy, 1(2), 203–12. -
Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen
Laport, G. G., Alvarnas, J. C., Palmer, J. M., Snyder, D. S., Slovak, M. L., Cherry, A. M., … Forman, S. J. (2008). Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen. BLOOD, 112(3), 903–9. -
Long-term results of autologous hematopoietic cell transplantation for peripheral T cell lymphoma: The Stanford experience
Chen, A. I., McMillan, A., Neprin, R. S., Horning, S. J., & Laport, G. G. (2008). Long-term results of autologous hematopoietic cell transplantation for peripheral T cell lymphoma: The Stanford experience. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14(7), 741–47. -
In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity
Nishimura, R., Baker, J., Beilhack, A., Zeiser, R., Olson, J. A., Sega, E. I., … Negrin, R. S. (2008). In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity. BLOOD, 112(6), 2563–74. -
Plasmacytoid dendritic cells take up opsonized antigen leading to CD4(+) and CD8(+) T cell activation in vivo
Bjorck, P., Beilhack, A., Herman, E. I., Negrin, R. S., & Engleman, E. G. (2008). Plasmacytoid dendritic cells take up opsonized antigen leading to CD4(+) and CD8(+) T cell activation in vivo. JOURNAL OF IMMUNOLOGY, 181(6), 3811–17. -
Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation
Reichardt, W., Duerr, C., von Elverfeldt, D., Juettner, E., Gerlach, U. V., Yamada, M., … Zeiser, R. (2008). Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation. JOURNAL OF IMMUNOLOGY, 181(7), 4770–79. -
Follicular lymphoma B cells induce the conversion of conventional CD4(+) T cells to T-regulatory cells
Ai, W. Z., Hou, L.-Z., Zeiser, R., Czerwinski, D., Negrin, R. S., & Levy, R. (2009). Follicular lymphoma B cells induce the conversion of conventional CD4(+) T cells to T-regulatory cells. INTERNATIONAL JOURNAL OF CANCER, 124(1), 239–44. -
Glycogen synthase kinase 3 beta missplicing contributes to leukemia stem cell generation
Abrahamsson, A. E., Geron, I., Gotlib, J., Dao, K.-H. T., Barroga, C. F., Newton, I. G., … Jamieson, C. H. M. (2009). Glycogen synthase kinase 3 beta missplicing contributes to leukemia stem cell generation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(10), 3925–29. -
TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
Kohrt, H. E., Turnbull, B. B., Heydari, K., Shizuru, J. A., Laport, G. G., Miklos, D. B., … Lowsky, R. (2009). TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors. BLOOD, 114(5), 1099–1109. -
Natural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor, and Graft-versus-Host Responses
Gill, S., Olson, J. A., & Negrin, R. S. (2009). Natural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor, and Graft-versus-Host Responses. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 15(7), 765–76. -
Long-term follow-up of patients with diffuse large B-cell non-Hodgkin's lymphoma receiving purged autografts after induction failure
Benjamin, J. E., Chen, G. L., Cao, T. M., Cao, P. D., Wong, R. M., Sheehan, K., … Laport, G. G. (2010). Long-term follow-up of patients with diffuse large B-cell non-Hodgkin's lymphoma receiving purged autografts after induction failure. BONE MARROW TRANSPLANTATION, 45(2), 303–9. -
Tissue-Specific Homing and Expansion of Donor NK Cells in Allogeneic Bone Marrow Transplantation
Olson, J. A., Zeiser, R., Beilhack, A., Goldman, J. J., & Negrin, R. S. (2009). Tissue-Specific Homing and Expansion of Donor NK Cells in Allogeneic Bone Marrow Transplantation. JOURNAL OF IMMUNOLOGY, 183(5), 3219–28. -
USE OF THE POLYMERASE CHAIN-REACTION TO MONITOR THE EFFECTIVENESS OF EX VIVO TUMOR-CELL PURGING
Negrin, R. S., Kiem, H. P., SCHMIDTWOLF, I. G. H., Blume, K. G., & Cleary, M. L. (1991). USE OF THE POLYMERASE CHAIN-REACTION TO MONITOR THE EFFECTIVENESS OF EX VIVO TUMOR-CELL PURGING. BLOOD, 77(3), 654–660. -
Immunoglobulin G Fc Receptor Fc gamma RIIIa 158 V/F Polymorphism Correlates With Rituximab-Induced Neutropenia After Autologous Transplantation in Patients With Non-Hodgkin's Lymphoma
Weng, W.-K., Negrin, R. S., Lavori, P., & Horning, S. J. (2010). Immunoglobulin G Fc Receptor Fc gamma RIIIa 158 V/F Polymorphism Correlates With Rituximab-Induced Neutropenia After Autologous Transplantation in Patients With Non-Hodgkin's Lymphoma. JOURNAL OF CLINICAL ONCOLOGY, 28(2), 279–84. -
Biology and clinical effects of natural killer cells in allogeneic transplantation
Benjamin, J. E., Gill, S., & Negrin, R. S. (2010). Biology and clinical effects of natural killer cells in allogeneic transplantation. CURRENT OPINION IN ONCOLOGY, 22(2), 130–37. -
Phase I/II Trial of GN-BVC, a Gemcitabine and Vinorelbine-Containing Conditioning Regimen for Autologous Hematopoietic Cell Transplantation in Recurrent and Refractory Hodgkin Lymphoma
Arai, S., Letsinger, R., Wong, R. M., Johnston, L. J., Laport, G. G., Lowsky, R., … Horning, S. J. (2010). Phase I/II Trial of GN-BVC, a Gemcitabine and Vinorelbine-Containing Conditioning Regimen for Autologous Hematopoietic Cell Transplantation in Recurrent and Refractory Hodgkin Lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 16(8), 1145–54. -
NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects
Olson, J. A., Leveson-Gower, D. B., Gill, S., Baker, J., Beilhack, A., & Negrin, R. S. (2010). NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects. BLOOD, 115(21), 4293–4301. -
THE STANFORD EXPERIENCE WITH HIGH-DOSE ETOPOSIDE CYTOREDUCTIVE REGIMENS AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA - PRELIMINARY DATA
Horning, S. J., Chao, N. J., Negrin, R. S., Hoppe, R. T., Kwak, L. W., Long, G. D., … Blume, K. G. (1991). THE STANFORD EXPERIENCE WITH HIGH-DOSE ETOPOSIDE CYTOREDUCTIVE REGIMENS AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA - PRELIMINARY DATA. ANNALS OF ONCOLOGY, 2, 47–50. -
Long-term outcomes in patients with high-risk myeloid malignancies following matched related donor hematopoietic cell transplantation with myeloablative conditioning of BU, etoposide and CY
Naik, S., Wong, R., Arai, S., Brown, J., Laport, G., Lowsky, R., … Johnston, L. (2011). Long-term outcomes in patients with high-risk myeloid malignancies following matched related donor hematopoietic cell transplantation with myeloablative conditioning of BU, etoposide and CY. BONE MARROW TRANSPLANTATION, 46(2), 192–99. -
Definition of an Enhanced Immune Cell Therapy in Mice That Can Target Stem-Like Lymphoma Cells
Contag, C. H., Sikorski, R., Negrin, R. S., Schmidt, T., Fan, A. C., Bachireddy, P., … Thorne, S. H. (2010). Definition of an Enhanced Immune Cell Therapy in Mice That Can Target Stem-Like Lymphoma Cells. CANCER RESEARCH, 70(23), 9837–45. -
Bone marrow transplantation for hematologic malignancies: the Stanford experience.
Chao, N. J., Amylon, M. D., Long, G. D., Negrin, R. S., Hoppe, R. T., Horning, S. J., & Blume, K. G. (1990). Bone marrow transplantation for hematologic malignancies: the Stanford experience. Clinical Transplants, 157–163. -
Autologous versus Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Patients with Chemosensitive Follicular Non-Hodgkin Lymphoma beyond First Complete Response or First Partial Response
Tomblyn, M. R., Ewell, M., Bredeson, C., Kahl, B. S., Goodman, S. A., Horowitz, M. M., … Laport, G. G. (2011). Autologous versus Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Patients with Chemosensitive Follicular Non-Hodgkin Lymphoma beyond First Complete Response or First Partial Response. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(7), 1051–57. -
CXCL12 Mediates Immunosuppression in the Lymphoma Microenvironment after Allogeneic Transplantation of Hematopoietic Cells
Duerr, C., Pfeifer, D., Claus, R., Schmitt-Graeff, A., Gerlach, U. V., Graeser, R., … Zeiser, R. (2010). CXCL12 Mediates Immunosuppression in the Lymphoma Microenvironment after Allogeneic Transplantation of Hematopoietic Cells. CANCER RESEARCH, 70(24), 10170–81. -
Natural and Expanded CD4(+) CD25(+) Regulatory T Cells in Bone Marrow Transplantation
Colonna, L., Sega, E. I., & Negrin, R. S. (2011). Natural and Expanded CD4(+) CD25(+) Regulatory T Cells in Bone Marrow Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(1), S58–S62. -
CD8(+)CD44(hi) but not CD4(+)CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD
Dutt, S., Baker, J., Kohrt, H. E., Kambham, N., Sanyal, M., Negrin, R. S., & Strober, S. (2011). CD8(+)CD44(hi) but not CD4(+)CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD. BLOOD, 117(11), 3230–39. -
Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism
Leveson-Gower, D. B., Olson, J. A., Sega, E. I., Luong, R. H., Baker, J., Zeiser, R., & Negrin, R. S. (2011). Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism. BLOOD, 117(11), 3220–29. -
Short-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells
Pearl, J. I., Lee, A. S., Leveson-Gower, D. B., Sun, N., Ghosh, Z., Lan, F., … Wu, J. C. (2011). Short-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells. CELL STEM CELL, 8(3), 309–17. -
Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation
Johnston, L., Florek, M., Armstrong, R., McCune, J. S., Arai, S., Brown, J., … Negrin, R. (2012). Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation. BONE MARROW TRANSPLANTATION, 47(4), 581–88. -
Tandem chemo-mobilization followed by high-dose melphalan and carmustine with single autologous hematopoietic cell transplantation for multiple myeloma
Chen, A. I., Negrin, R. S., McMillan, A., Shizuru, J. A., JOHNSTON, L. J., Lowsky, R., … Stockerl-Goldstein, K. (2012). Tandem chemo-mobilization followed by high-dose melphalan and carmustine with single autologous hematopoietic cell transplantation for multiple myeloma. BONE MARROW TRANSPLANTATION, 47(4), 516–21. -
Adoptive Immunotherapy with Cytokine-Induced Killer Cells for Patients with Relapsed Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation
Laport, G. G., Sheehan, K., Baker, J., Armstrong, R., Wong, R. M., Lowsky, R., … Negrin, R. S. (2011). Adoptive Immunotherapy with Cytokine-Induced Killer Cells for Patients with Relapsed Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(11), 1679–87. -
Long-Term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy and Transplantation of Purified Autologous Hematopoietic Stem Cells
Mueller, A. M. S., Kohrt, H. E. K., Cha, S., Laport, G., Klein, J., Guardino, A. E., … Shizuru, J. A. (2012). Long-Term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy and Transplantation of Purified Autologous Hematopoietic Stem Cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 18(1), 125–33. -
Role of regulatory T cell populations in controlling graft vs host disease
Negrin, R. S. (2011). Role of regulatory T cell populations in controlling graft vs host disease. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 24(3), 453–57. -
Co-transplantation of pure blood stem cells with antigen-specific but not bulk T cells augments functional immunity
Mueller, A. M. S., Shashidhar, S., Kuepper, N. J., Kohrt, H. E. K., Florek, M., Negrin, R. S., … Shizuru, J. A. (2012). Co-transplantation of pure blood stem cells with antigen-specific but not bulk T cells augments functional immunity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(15), 5820–25. -
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
Gill, S., Vasey, A. E., De Souza, A., Baker, J., Smith, A. T., Kohrt, H. E., … Negrin, R. S. (2012). Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. BLOOD, 119(24), 5758–68. -
Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence
Arai, S., Sahaf, B., Narasimhan, B., Chen, G. L., Jones, C. D., Lowsky, R., … Miklos, D. B. (2012). Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence. BLOOD, 119(25), 6145–54. -
THE USE OF HEMATOPOIETIC GROWTH-FACTORS IN THE TREATMENT OF MYELODYSPLASTIC SYNDROMES
Greenberg, P. L., Negrin, R., & Nagler, A. (1990). THE USE OF HEMATOPOIETIC GROWTH-FACTORS IN THE TREATMENT OF MYELODYSPLASTIC SYNDROMES. CANCER SURVEYS, 9(1), 199–212. -
Cancer Vaccines and T Cell Therapy
Rezvani, K., Brody, J. D., Kohrt, H. E., Logan, A. C., Advani, R., Czerwinski, D. K., … Barrett, J. (2013). Cancer Vaccines and T Cell Therapy. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19(1), S97–S101. -
A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease.
Meyer, E. H., Hsu, A. R., Liliental, J., Löhr, A., Florek, M., Zehnder, J. L., … Negrin, R. S. (2013). A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease. Blood, 121(24), 4955–62. -
TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR - A PHASE I-II TRIAL
Negrin, R. S., HAEUBER, D. H., Nagler, A., Olds, L. C., Donlon, T., SOUZA, L. M., & Greenberg, P. L. (1989). TREATMENT OF MYELODYSPLASTIC SYNDROMES WITH RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR - A PHASE I-II TRIAL. ANNALS OF INTERNAL MEDICINE, 110(12), 976–84. -
LYMPHOKINE-ACTIVATED KILLER CELL-ACTIVITY AFTER CRYOPRESERVATION
SCHMIDTWOLF, I. G. H., Aihara, M., Negrin, R. S., Blume, K. G., & Chao, N. J. (1989). LYMPHOKINE-ACTIVATED KILLER CELL-ACTIVITY AFTER CRYOPRESERVATION. JOURNAL OF IMMUNOLOGICAL METHODS, 125(1-2), 185–189. -
NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE IN ATELECTASIS
Duncan, S. R., Negrin, R. S., Mihm, F. G., Guilleminault, C., & Raffin, T. A. (1987). NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE IN ATELECTASIS. CHEST, 92(4), 621–24. -
A RANDOMIZED STUDY OF ERYTHROPOIETIN AND GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) VERSUS PLACEBO AND G-CSF FOR PATIENTS WITH HODGKINS AND NON-HODGKINS-LYMPHOMA UNDERGOING AUTOLOGOUS BONE-MARROW TRANSPLANTATION
Chao, N. J., Schriber, J. R., Long, G. D., Negrin, R. S., CATOLICO, M., Brown, B. W., … Blume, K. G. (1994). A RANDOMIZED STUDY OF ERYTHROPOIETIN AND GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) VERSUS PLACEBO AND G-CSF FOR PATIENTS WITH HODGKINS AND NON-HODGKINS-LYMPHOMA UNDERGOING AUTOLOGOUS BONE-MARROW TRANSPLANTATION. BLOOD, 83(10), 2823–28. -
A NOVEL POPULATION OF EXPANDED HUMAN CD3+CD56+ CELLS DERIVED FROM T-CELLS WITH POTENT IN-VIVO ANTITUMOR-ACTIVITY IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY
Lu, P. H., & Negrin, R. S. (1994). A NOVEL POPULATION OF EXPANDED HUMAN CD3+CD56+ CELLS DERIVED FROM T-CELLS WITH POTENT IN-VIVO ANTITUMOR-ACTIVITY IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY. JOURNAL OF IMMUNOLOGY, 153(4), 1687–1696. -
GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
Schriber, J. R., Chao, N. J., Long, G. D., Negrin, R. S., Tierney, D. K., KUSNIERZGLAZ, C., … Blume, K. G. (1994). GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION. BLOOD, 84(5), 1680–84. -
EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY ON IN-VITRO HEMATOPOIESIS IN MYELODYSPLASTIC SYNDROMES
Nagler, A., MacKichan, M. L., Negrin, R. S., Donlon, T., & Greenberg, P. L. (1995). EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY ON IN-VITRO HEMATOPOIESIS IN MYELODYSPLASTIC SYNDROMES. LEUKEMIA, 9(1), 30–39. -
TRANSPLANTATION OF ENRICHED AND PURGED PERIPHERAL-BLOOD PROGENITOR CELLS FROM A SINGLE APHERESIS PRODUCT IN PATIENTS WITH NON-HODGKINS-LYMPHOMA
Negrin, R. S., KUSNIERZGLAZ, C. R., Still, B. J., Schriber, J. R., Chao, N. J., Long, G. D., … Strober, S. (1995). TRANSPLANTATION OF ENRICHED AND PURGED PERIPHERAL-BLOOD PROGENITOR CELLS FROM A SINGLE APHERESIS PRODUCT IN PATIENTS WITH NON-HODGKINS-LYMPHOMA. BLOOD, 85(11), 3334–41. -
ENRICHMENT OF BONE-MARROW AND BLOOD PROGENITOR (CD34(+)) CELLS BY DENSITY GRADIENTS WITH SUFFICIENT YIELDS FOR TRANSPLANTATION
Schriber, J. R., DEJBAKHSHJONES, S., KUSNIERZGLAZ, C. R., Ginzton, N., Still, B., Negrin, R. S., … Strober, S. (1995). ENRICHMENT OF BONE-MARROW AND BLOOD PROGENITOR (CD34(+)) CELLS BY DENSITY GRADIENTS WITH SUFFICIENT YIELDS FOR TRANSPLANTATION. EXPERIMENTAL HEMATOLOGY, 23(9), 1024–29. -
2 PATHWAYS OF EXOCYTOSIS OF CYTOPLASMIC GRANULE CONTENTS AND TARGET-CELL KILLING BY CYTOKINE-INDUCED CD3(+)CD56(+) KILLER-CELLS
Mehta, B. A., SCHMIDTWOLF, G. H., Weissman, I. L., & Negrin, R. S. (1995). 2 PATHWAYS OF EXOCYTOSIS OF CYTOPLASMIC GRANULE CONTENTS AND TARGET-CELL KILLING BY CYTOKINE-INDUCED CD3(+)CD56(+) KILLER-CELLS. BLOOD, 86(9), 3493–99. -
GRANULOCYTE COLONY-STIMULATING FACTOR MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS ACCELERATE GRANULOCYTE AND PLATELET RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY
Chao, N. J., Schriber, J. R., Grimes, K., Long, G. D., Negrin, R. S., RAIMONDI, C. M., … Blume, K. G. (1993). GRANULOCYTE COLONY-STIMULATING FACTOR MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS ACCELERATE GRANULOCYTE AND PLATELET RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY. BLOOD, 81(8), 2031–35. -
USE AND TOXICITY OF THE COLONY-STIMULATING FACTORS
Schriber, J. R., & Negrin, R. S. (1993). USE AND TOXICITY OF THE COLONY-STIMULATING FACTORS. DRUG SAFETY, 8(6), 457–68. -
TREATMENT OF THE ANEMIA OF MYELODYSPLASTIC SYNDROMES USING RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN COMBINATION WITH ERYTHROPOIETIN
Negrin, R. S., Stein, R., Vardiman, J., Doherty, K., Cornwell, J., Krantz, S., & Greenberg, P. L. (1993). TREATMENT OF THE ANEMIA OF MYELODYSPLASTIC SYNDROMES USING RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN COMBINATION WITH ERYTHROPOIETIN. BLOOD, 82(3), 737–43. -
THE EFFICACY OF GRANULOCYTE-COLONY-STIMULATING FACTOR FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR NON-HODGKINS-LYMPHOMA WITH MONOCLONAL-ANTIBODY PURGED BONE-MARROW
Schriber, J. R., Negrin, R. S., Chao, N. J., Long, G. D., Horning, S. J., & Blume, K. G. (1993). THE EFFICACY OF GRANULOCYTE-COLONY-STIMULATING FACTOR FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR NON-HODGKINS-LYMPHOMA WITH MONOCLONAL-ANTIBODY PURGED BONE-MARROW. LEUKEMIA, 7(10), 1491–95. -
PHENOTYPIC CHARACTERIZATION AND IDENTIFICATION OF EFFECTOR-CELLS INVOLVED IN TUMOR-CELL RECOGNITION OF CYTOKINE-INDUCED KILLER-CELLS
SCHMIDTWOLF, I. G. H., Lefterova, P., Mehta, B. A., Fernandez, L. P., HUHN, L. D., Blume, K. G., … Negrin, R. S. (1993). PHENOTYPIC CHARACTERIZATION AND IDENTIFICATION OF EFFECTOR-CELLS INVOLVED IN TUMOR-CELL RECOGNITION OF CYTOKINE-INDUCED KILLER-CELLS. EXPERIMENTAL HEMATOLOGY, 21(13), 1673–1679. -
ROLE OF ETOPOSIDE (VP-16) IN PREPARATORY REGIMENS FOR PATIENTS WITH LEUKEMIA OR LYMPHOMA UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION
Blume, K. G., Long, G. D., Negrin, R. S., Chao, N. J., KUSNIERZGLAZ, C., & Amylon, M. D. (1994). ROLE OF ETOPOSIDE (VP-16) IN PREPARATORY REGIMENS FOR PATIENTS WITH LEUKEMIA OR LYMPHOMA UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION. Presented at the Symposium on Allogeneic Bone Marrow Transplantation - State of the Art and Future Directions, ESSEN,GERMANY: STOCKTON PRESS. -
A NEW PREPARATORY REGIMEN FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR PATIENTS WITH LYMPHOMA
Chao, N. J., Kastrissios, H., Long, G. D., Negrin, R. S., Horning, S. J., Wong, R. M., … Blume, K. G. (1995). A NEW PREPARATORY REGIMEN FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR PATIENTS WITH LYMPHOMA. CANCER, 75(6), 1354–59. -
IS NITROUS-OXIDE SAFE FOR BONE-MARROW HARVEST
Lederhaas, G., BROCKUTNE, J. G., Negrin, R. S., Riley, E., & Brodsky, J. B. (1995). IS NITROUS-OXIDE SAFE FOR BONE-MARROW HARVEST. ANESTHESIA AND ANALGESIA, 80(4), 770–72. -
THE ROLE OF N-LINKED CARBOHYDRATE RESIDUES IN LYMPHOKINE-ACTIVATED KILLER CELL-MEDIATED CYTOLYSIS
Mehta, B. A., Collard, H. R., & Negrin, R. S. (1994). THE ROLE OF N-LINKED CARBOHYDRATE RESIDUES IN LYMPHOKINE-ACTIVATED KILLER CELL-MEDIATED CYTOLYSIS. CELLULAR IMMUNOLOGY, 155(1), 95–110. -
FRACTIONATED TOTAL-BODY IRRADIATION, ETOPOSIDE, AND CYCLOPHOSPHAMIDE PLUS AUTOGRAFTING IN HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA
Horning, S. J., Negrin, R. S., Chao, N. J., Long, G. D., Hoppe, R. T., & Blume, K. G. (1994). FRACTIONATED TOTAL-BODY IRRADIATION, ETOPOSIDE, AND CYCLOPHOSPHAMIDE PLUS AUTOGRAFTING IN HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA. JOURNAL OF CLINICAL ONCOLOGY, 12(12), 2552–58. -
FRACTIONATED TOTAL-BODY IRRADIATION AND HIGH-DOSE ETOPOSIDE AS A PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR 94 PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE
Snyder, D. S., Negrin, R. S., ODONNELL, M. R., Chao, N. J., Amylon, M. D., Long, G. D., … Blume, K. G. (1994). FRACTIONATED TOTAL-BODY IRRADIATION AND HIGH-DOSE ETOPOSIDE AS A PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR 94 PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE. BLOOD, 84(5), 1672–79. -
DETECTION OF TUMOR-CELLS IN PURGED BONE-MARROW AND PERIPHERAL-BLOOD MONONUCLEAR-CELLS BY POLYMERASE CHAIN-REACTION AMPLIFICATION OF BCL-2 TRANSLOCATIONS
Negrin, R. S., & PESANDO, J. (1994). DETECTION OF TUMOR-CELLS IN PURGED BONE-MARROW AND PERIPHERAL-BLOOD MONONUCLEAR-CELLS BY POLYMERASE CHAIN-REACTION AMPLIFICATION OF BCL-2 TRANSLOCATIONS. JOURNAL OF CLINICAL ONCOLOGY, 12(5), 1021–27. -
Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission.
Snyder, D. S., Chao, N. J., Amylon, M. D., Taguchi, J., Long, G. D., Negrin, R. S., … Stein, A. S. (1993). Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission. Blood, 82(9), 2920–2928. -
CYCLOSPORINE, METHOTREXATE, AND PREDNISONE COMPARED WITH CYCLOSPORINE AND PREDNISONE FOR PROPHYLAXIS OF ACUTE GRAFT-VERSUS-HOST DISEASE
Chao, N. J., Schmidt, G. M., Niland, J. C., Amylon, M. D., Dagis, A. C., Long, G. D., … Forman, S. J. (1993). CYCLOSPORINE, METHOTREXATE, AND PREDNISONE COMPARED WITH CYCLOSPORINE AND PREDNISONE FOR PROPHYLAXIS OF ACUTE GRAFT-VERSUS-HOST DISEASE. NEW ENGLAND JOURNAL OF MEDICINE, 329(17), 1225–30. -
BUSULFAN ETOPOSIDE - INITIAL EXPERIENCE WITH A NEW PREPARATORY REGIMEN FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN PATIENTS WITH ACUTE NONLYMPHOBLASTIC LEUKEMIA
Chao, N. J., Stein, A. S., Long, G. D., Negrin, R. S., Amylon, M. D., Wong, R. M., … Blume, K. G. (1993). BUSULFAN ETOPOSIDE - INITIAL EXPERIENCE WITH A NEW PREPARATORY REGIMEN FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN PATIENTS WITH ACUTE NONLYMPHOBLASTIC LEUKEMIA. BLOOD, 81(2), 319–23. -
BUSULFAN/CYCLOPHOSPHAMIDE AS CONDITIONING REGIMEN FOR ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR MYELODYSPLASIA
ODONNELL, M. R., Long, G. D., Parker, P. M., Niland, J., Nademanee, A., Amylon, M., … Forman, S. J. (1995). BUSULFAN/CYCLOPHOSPHAMIDE AS CONDITIONING REGIMEN FOR ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR MYELODYSPLASIA. JOURNAL OF CLINICAL ONCOLOGY, 13(12), 2973–2979. -
MULTIPLE CYCLES OF HIGH-DOSE CHEMOTHERAPY SUPPORTED BY HEMATOPOIETIC PROGENITOR CELLS AS TREATMENT FOR PATIENTS WITH ADVANCED MALIGNANCIES
Long, G. D., Negrin, R. S., Hoyle, C. F., KUSNIERZGLAZ, C. R., Schriber, J. R., Blume, K. G., & Chao, N. J. (1995). MULTIPLE CYCLES OF HIGH-DOSE CHEMOTHERAPY SUPPORTED BY HEMATOPOIETIC PROGENITOR CELLS AS TREATMENT FOR PATIENTS WITH ADVANCED MALIGNANCIES. CANCER, 76(5), 860–68. -
Maintenance treatment of the anemia of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor and erythropoietin: Evidence for in vivo synergy
Negrin, R. S., Stein, R., Doherty, K., Cornwell, J., Vardiman, J., Krantz, S., & Greenberg, P. L. (1996). Maintenance treatment of the anemia of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor and erythropoietin: Evidence for in vivo synergy. BLOOD, 87(10), 4076–81. -
Enrichment of allogeneic CD34+ cells and T cell depletion by percoll density gradient centrifugation
Negrin, R. S., KUSNIERZGLAZ, C., Blume, K. G., & Strober, S. (1996). Enrichment of allogeneic CD34+ cells and T cell depletion by percoll density gradient centrifugation. Presented at the 1st International Symposium on Allogeneic Peripheral Blood Precursor Cell Transplants, GENEVA,SWITZERLAND,SWITZERLAND,SWITZERLAND,SWITZERLAND,SWITZERLAND,SWITZERLAND: STOCKTON PRESS. -
High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma
Long, G. D., Chao, N. J., Hu, W. W., Negrin, R. S., Wong, R. M., & Blume, K. G. (1996). High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma. CANCER, 78(12), 2502–9. -
Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies
KUSNIERZGLAZ, C. R., Schlegel, P. G., Wong, R. M., Schriber, J. R., Chao, N. J., Amylon, M. D., … Long, G. D. (1997). Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 15(1), 18–25. -
High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin's disease: Analysis of the Stanford University results and prognostic indices
Horning, S. J., Chao, N. J., Negrin, R. S., Hoppe, R. T., Long, G. D., Hu, W. W., … Blume, K. G. (1997). High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin's disease: Analysis of the Stanford University results and prognostic indices. BLOOD, 89(3), 801–13. -
Granulocyte colony-stimulating factor-induced comobilization of CD4(-)CD8(-) T cells and hematopoietic progenitor cells (CD34(+)) in the blood of normal donors
KUSNIERZGLAZ, C. R., Still, B. J., Amano, M., Zukor, J. D., Negrin, R. S., Blume, K. G., & Strober, S. (1997). Granulocyte colony-stimulating factor-induced comobilization of CD4(-)CD8(-) T cells and hematopoietic progenitor cells (CD34(+)) in the blood of normal donors. BLOOD, 89(7), 2586–95. -
Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma.
Stockerl-Goldstein, K. E., Horning, S. J., Negrin, R. S., Chao, N. J., Hu, W. W., Long, G. D., … Blume, K. G. (1996). Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation , 2(2), 76–85. -
Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease.
Chao, N. J., Parker, P. M., Niland, J. C., Wong, R. M., Dagis, A., Long, G. D., … Blume, K. G. (1996). Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease. Biology of Blood and Marrow Transplantation , 2(2), 86–92. -
Cellular immunotherapy following autologous hematopoietic progenitor cell transplantation.
Lu, P. H., & Negrin, R. S. (1997). Cellular immunotherapy following autologous hematopoietic progenitor cell transplantation. Biology of Blood and Marrow Transplantation , 3(3), 113–121. -
Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies.
Long, G. D., Amylon, M. D., Stockerl-Goldstein, K. E., Negrin, R. S., Chao, N. J., Hu, W. W., … Blume, K. G. (1997). Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies. Biology of Blood and Marrow Transplantation , 3(6), 324–30. -
Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: In vitro and in vivo efficacy in severe combined immunodeficiency disease mice
Hoyle, C., Bangs, C. D., Chang, P., Kamel, O., Mehta, B., & Negrin, R. S. (1998). Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: In vitro and in vivo efficacy in severe combined immunodeficiency disease mice. BLOOD, 92(9), 3318–27. -
Minimal residual disease.
Negrin, R. S. (1998). Minimal residual disease. Current Opinion in Hematology, 5(6), 488–493. -
Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma
Knox, S. J., Goris, M. L., Trisler, K., Negrin, R., Davis, T., Liles, T. M., … Levy, R. (1996). Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. CLINICAL CANCER RESEARCH, 2(3), 457–70. -
Tandem Autologous Stem Cell Transplants (auto-auto) With or without Maintenance Therapy Versus Single Autologous Transplant Followed by HLA-Matched Sibling Non- Myeloablative Allogeneic Stem Cell Transplant (auto-allo) for Patients (pts) with High Risk (HR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT-CTN) 0102 Trial
Stadtmauer, E. A., Krishnan, A., Pasquini, M. C., Ewell, M., Alyea, E. P., Antin, J. H., … Giralt, S. (2010). Tandem Autologous Stem Cell Transplants (auto-auto) With or without Maintenance Therapy Versus Single Autologous Transplant Followed by HLA-Matched Sibling Non- Myeloablative Allogeneic Stem Cell Transplant (auto-allo) for Patients (pts) with High Risk (HR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT-CTN) 0102 Trial. BLOOD, 116(21), 233–34. -
Tandem Autologous Hematopoietic Stem Cell Transplants (AuHCT) with or without Maintenance Therapy (auto-auto) Versus Single AuHCT Followed by HLA Matched Sibling Non- Myeloablative Allogeneic HCT (auto-allo) for Patients with Standard Risk (SR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 Trial
Krishnan, A., Pasquini, M. C., Ewell, M., Stadtmauer, E. A., Alyea, E. P., Antin, J. H., … Maloney, D. G. (2010). Tandem Autologous Hematopoietic Stem Cell Transplants (AuHCT) with or without Maintenance Therapy (auto-auto) Versus Single AuHCT Followed by HLA Matched Sibling Non- Myeloablative Allogeneic HCT (auto-allo) for Patients with Standard Risk (SR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 Trial. BLOOD, 116(21), 24–25. -
Blood and marrow transplant clinical trials network state of the science symposium 2007
Ferrara, J. L. M., Anasetti, C., Stadtmauer, E., Antin, J., Wingard, J., Lee, S., … Horowitz, M. (2007). Blood and marrow transplant clinical trials network state of the science symposium 2007. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 13(11), 1268–85. -
Missplicing of glycogen synthase kinase 3 beta: A potential mechanism of blast crisis chronic myeloid leukemia stem cell generation
Abrahamsson, A., Geron, I., Gotlib, J., Dao, K.-H., Giles, F., Newton, I., … Jamieson, C. H. M. (2007). Missplicing of glycogen synthase kinase 3 beta: A potential mechanism of blast crisis chronic myeloid leukemia stem cell generation. BLOOD, 110(11), 238A–239A. -
LONG-TERM FOLLOW-UP OF METASTATIC BREAST CANCER PATIENTS RECEIVING HIGHLY PURIFIED AUTOLOGOUS CD34+THY-1+HEMATOPOIETIC STEM CELLS AFTER HIGH-DOSE CHEMOTHERAPY
Mueller, A. M. S., Kohrt, H. E. K., Laport, G. G., Negrin, R. S., Cha, S., Weissman, I. L., & Shizuru, J. A. (2011). LONG-TERM FOLLOW-UP OF METASTATIC BREAST CANCER PATIENTS RECEIVING HIGHLY PURIFIED AUTOLOGOUS CD34+THY-1+HEMATOPOIETIC STEM CELLS AFTER HIGH-DOSE CHEMOTHERAPY. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(2), S198–S198. -
Immunotherapy of primary ovarian cancer using autologous cytokine induced killer cells retargeted with bispecific antibodies: A preclinical study.
Chan, J. K., Hamilton, C. A., Cheung, M. K., Karimi, M., Baker, J., Gall, J. M., … Negrin, R. S. (2005). Immunotherapy of primary ovarian cancer using autologous cytokine induced killer cells retargeted with bispecific antibodies: A preclinical study. BLOOD, 106(11), 669A–670A. -
Isolation and characterization of human CD4+CD25+T regulatory cells for early phase clinical trials in hematopoietic cell transplantation.
Hou, J. Z., Baker, J., Sheehan, K., & Negrin, R. S. (2005). Isolation and characterization of human CD4+CD25+T regulatory cells for early phase clinical trials in hematopoietic cell transplantation. BLOOD, 106(11), 368A–368A. -
Prevention of acute graft-versus-host disease by CD4+ CD25+ regulatory T cells is dependent on the CD30/CD153 pathway.
Zeiser, R., Nguyen, V., Buess, M., Karimi, M., Bjorck, P., Baker, J., & Negrin, R. S. (2005). Prevention of acute graft-versus-host disease by CD4+ CD25+ regulatory T cells is dependent on the CD30/CD153 pathway. BLOOD, 106(11), 378A–378A. -
Allogeneic cytokine-induced killer cells traffick to GVHD target tissue but cause less GVHD, while retaining tumor cytotoxicity and facilitating bone marrow engraftment.
Nishimura, R., Baker, J., Beilhack, A., & Negrin, R. (2006). Allogeneic cytokine-induced killer cells traffick to GVHD target tissue but cause less GVHD, while retaining tumor cytotoxicity and facilitating bone marrow engraftment. BLOOD, 108(11), 904A–904A. -
Type IIHMG-CoA reductase inhibitors (Statins) provide acute-graft-versus-host disease protection by Th-2 cytokine induction while sparing graft-versus-leukemia activity.
Zeiser, R., Youssef, S., Baker, J., Steinman, L., & Negrin, R. (2006). Type IIHMG-CoA reductase inhibitors (Statins) provide acute-graft-versus-host disease protection by Th-2 cytokine induction while sparing graft-versus-leukemia activity. BLOOD, 108(11), 60A–60A. -
Bisphosphonate and IPP expanded gamma delta T cells have in vitro and in vivo antitumor function.
Baker, J., Verneris, M. R., Kivivuori, S. M., Schimmelpfennig, C. H., & Negrin, R. S. (2001). Bisphosphonate and IPP expanded gamma delta T cells have in vitro and in vivo antitumor function. BLOOD, 98(11), 167A–167A. -
Characterization of ex vivo expanded gamma/delta T cells.
Kivivuori, S. M., Verneris, M. R., Baker, J., & Negrin, R. S. (2001). Characterization of ex vivo expanded gamma/delta T cells. BLOOD, 98(11), 235A–235A. -
In vivo trafficking of activated T cells in allogeneic recipients using bioluminescent imaging.
Wieland, C. B., Beilhack, A., Baker, J., Cao, Y. A., Herman, E., Baker, E., … Negrin, R. S. (2003). In vivo trafficking of activated T cells in allogeneic recipients using bioluminescent imaging. BLOOD. SAN DIEGO,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA: AMER SOC HEMATOLOGY. -
Silensilencing human NKG2D, DAP10 and DAP12 reduces cytotoxicity of in vivo activated CD8(+) T and NK cells
Karimi, M. A., Cao, T., Verneris, M. R., Baker, J., & Negrin, R. S. (2004). Silensilencing human NKG2D, DAP10 and DAP12 reduces cytotoxicity of in vivo activated CD8(+) T and NK cells. BLOOD, 104(11), 130A–131A. -
NK Cells Suppress Gvhd by Directly Inhibiting Activated Alloreactive T Cells through An NKG2D-Mediated Mechanism
Olson, J. A., Leveson-Gower, D. B., Baker, J., Bcilhack, A., & Negrin, R. (2008). NK Cells Suppress Gvhd by Directly Inhibiting Activated Alloreactive T Cells through An NKG2D-Mediated Mechanism. BLOOD, 112(11), 30–30. -
Simultaneous blockade of several endothelial ligands is required to prevent alloreactive T-cell trafficking to target tissues
Beilhack, A., Baker, J., Riedel, S., Brede, C., Baeuerlein, C. A., Jordan-Garrote, A. L., … Schulz, S. (2010). Simultaneous blockade of several endothelial ligands is required to prevent alloreactive T-cell trafficking to target tissues. Presented at the 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, VIENNA,AUSTRIA: NATURE PUBLISHING GROUP. -
CD11B+CD11C+DENDRITIC CELLS INTERACT WITH ALLOREACTIVE T CELLS IN THE INTESTINAL MUCOSA IN ACUTE GRAFT-VERSUS-HOST DISEASE
Garrote, A. L. J., Brede, C., Baeuerlein, C., Riedel, S., Kiesel, C., Grether, M., … Schulz, S. (2010). CD11B+CD11C+DENDRITIC CELLS INTERACT WITH ALLOREACTIVE T CELLS IN THE INTESTINAL MUCOSA IN ACUTE GRAFT-VERSUS-HOST DISEASE. Presented at the 15th Annual Meeting of the European-Hematology-Association, BARCELONA,SPAIN: FERRATA STORTI FOUNDATION. -
KINETICS OF MURINE GVHD INDUCTION ACROSS MINOR AND MAJOR HISTOCOMPATIBILITY BARRIERS
Vasey, A. E., Baker, J. B., Leveson-Gower, D. B., & Negrin, R. S. (2011). KINETICS OF MURINE GVHD INDUCTION ACROSS MINOR AND MAJOR HISTOCOMPATIBILITY BARRIERS. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(2), S340–S340. -
Similarities In the Initial Events of Murine Gvhd Across Minor. as Compared to Major, Histocompatibility Barriers
Vasey, A. E., Baker, J. B., Leyeson-Gower, D. B., & Negrin, R. (2010). Similarities In the Initial Events of Murine Gvhd Across Minor. as Compared to Major, Histocompatibility Barriers. BLOOD, 116(21), 1537–38. -
Natural Killer Cell Adoptive Immunotherapy Is Hampered by A Rapid Development of NK Cell Dysfunction Characterized by Loss of Effector Mechanisms and Downregulation of the Transcription Factors T-Bet and Eomesodermin; Definition and Possible Mechanism of NK Cell Exhaustion
Gill, S. I., Vasey, A. E., Baker, J. B., Smith, A., Kohrt, H. E., Florek, M., … Negrin, R. S. (2011). Natural Killer Cell Adoptive Immunotherapy Is Hampered by A Rapid Development of NK Cell Dysfunction Characterized by Loss of Effector Mechanisms and Downregulation of the Transcription Factors T-Bet and Eomesodermin; Definition and Possible Mechanism of NK Cell Exhaustion. BLOOD, 118(21), 457–57. -
A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
Baeuerlein, C. A., Riedel, S. S., Baker, J., Brede, C., Garrote, A.-L. J., Chopra, M., … Beilhack, A. (2013). A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model. BMC MEDICINE, 11. -
Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8(+) T cells
Verneris, M. R., Karami, M., Baker, J., Jayaswal, A., & Negrin, R. S. (2004). Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8(+) T cells. BLOOD, 103(8), 3065–72. -
Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4(+)CD25(+)Foxp3(+) regulatory T cells
Shin, H.-J., Baker, J., Leveson-Gower, D. B., Smith, A. T., Sega, E. I., & Negrin, R. S. (2011). Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4(+)CD25(+)Foxp3(+) regulatory T cells. BLOOD, 118(8), 2342–50. -
Immunoglobulin G Fc polymorphism is correlated with rituximab-induced neutropenia following autologous hematopoietic cell transplantation.
Weng, W. K., Horning, S. J., Negrin, R. S., & Levy, R. (2004). Immunoglobulin G Fc polymorphism is correlated with rituximab-induced neutropenia following autologous hematopoietic cell transplantation. BLOOD, 104(11), 129A–129A. -
Immunotransplant for Mantle Cell Lymphoma: Phase I/II Study Preliminary Results
Brody, J. D., Czerwinski, D. K., Carlton, V., Moorhead, M., Zheng, J., Klinger, M., … Levy, R. (2011). Immunotransplant for Mantle Cell Lymphoma: Phase I/II Study Preliminary Results. BLOOD, 118(21), 1323–23. -
G-CSF AND PERIPHERAL-BLOOD PROGENITOR CELLS
Chao, N. J., Long, G. D., Negrin, R. S., Schriber, J. R., RAIMONDI, C. M., Brown, S. L., & Blume, K. G. (1992). G-CSF AND PERIPHERAL-BLOOD PROGENITOR CELLS. LANCET, 339(8806), 1410–1410. -
Deletion in H-NKG2D ligand effects tumors resistance to T-cells mediated cytotoxicity.
Karimi, M., Su, L., Chan, J., & Negrin, R. (2006). Deletion in H-NKG2D ligand effects tumors resistance to T-cells mediated cytotoxicity. Presented at the 6th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, SAN FRANCISCO,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA: ACADEMIC PRESS INC ELSEVIER SCIENCE. -
Deletion mutation in human NKG2D ligand effects tumors resistance to T cells mediated cytotoxicity
Karimi, M. A., Su, L., Chan, J. K., & Negrin, R. S. (2006). Deletion mutation in human NKG2D ligand effects tumors resistance to T cells mediated cytotoxicity. Presented at the Annual Meeting of the American-Association-of-Immunologists, BOSTON,MA,MA,MA,MA,MA,MA,MA,MA,MA,MA,MA,MA,MA: AMER ASSOC IMMUNOLOGISTS. -
Protective conditioning for acute graft-versus-host disease - Reply
Lowsky, R., Negrin, R. S., & Strober, S. (2005). Protective conditioning for acute graft-versus-host disease - Reply. NEW ENGLAND JOURNAL OF MEDICINE, 353(25), 2718–2718. -
Outcomes After Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation with Total Lymphoid Irradiation and Anti-Thymocyte Globulin in Lymphoid Malignancies After Failed Autologous Transplantation
Kanate, A. S., Efron, B., Chhabra, S., Kohrt, H., Shizuru, J. A., Laport, G. G., … Lowsky, R. (2013). Outcomes After Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation with Total Lymphoid Irradiation and Anti-Thymocyte Globulin in Lymphoid Malignancies After Failed Autologous Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19(2), S154–S155. -
TLI-ATG Conditioning and Allogeneic Transplantation for Patients with MDS and MPN
Benjamin, J., Chhabra, S., Kohrt, H., Laport, G. G., Arai, S., Johnston, L., … Lowsky, R. (2013). TLI-ATG Conditioning and Allogeneic Transplantation for Patients with MDS and MPN. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19(2), S113–S114. -
High dose therapy and autologous hematopoietic cell transplantation for follicular lymphoma beyond first remission: The Stanford University experience.
Cao, T. M., Negrin, R. S., Hu, W. W., JOHNSTON, L. J., Taylor, T. L., Shizuru, J. A., … Stockerl-Goldstein, K. E. (2000). High dose therapy and autologous hematopoietic cell transplantation for follicular lymphoma beyond first remission: The Stanford University experience. BLOOD, 96(11), 482A–482A. -
Non-Myeloablative Conditioning with Total Lymphoid Irradiation and ATG and Allogeneic Transplantation for Patients with Myelodysplastic Syndrome, Therapy-Related Myeloid Neoplasms, and Myeloproliferative Neoplasms.
Benjamin, J., Chhabra, S., Kohrt, H. E., Laport, G. G., Arai, S., Johnston, L., … Lowsky, R. (2012). Non-Myeloablative Conditioning with Total Lymphoid Irradiation and ATG and Allogeneic Transplantation for Patients with Myelodysplastic Syndrome, Therapy-Related Myeloid Neoplasms, and Myeloproliferative Neoplasms. BLOOD, 120(21). -
Increased transplant-related mortality following high-dose sequential chemotherapy and autologous hematopoietic cell transplantation (AHCT) using the Ceprate SC stem cell concentration system for multiple myeloma (MM).
Stockerl-Goldstein, K. E., Brown, J. M., O'Brien, R. M., Negrin, R. S., Hu, W. W., JOHNSTON, L. J., … Blume, K. G. (1999). Increased transplant-related mortality following high-dose sequential chemotherapy and autologous hematopoietic cell transplantation (AHCT) using the Ceprate SC stem cell concentration system for multiple myeloma (MM). BLOOD, 94(10), 608A–608A. -
Adjuvant rituximab after autologous peripheral blood stem cell transplant (APBSCT) results in delayed immune reconstitution without increase in infectious complications.
Horwitz, S. M., Breslin, S., Negrin, R. S., Stockerl-Goldstein, K. E., JOHNSTON, L. J., Shizuru, J. A., … Horning, S. J. (2000). Adjuvant rituximab after autologous peripheral blood stem cell transplant (APBSCT) results in delayed immune reconstitution without increase in infectious complications. BLOOD, 96(11), 384A–384A. -
Phase II trial of rituximab as adjuvant therapy to high dose chemotherapy and peripheral blood stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphomas.
Horwitz, S. M., Negrin, R. S., Stockerl-Goldstein, K. E., JOHNSTON, L. J., Shizuru, J. A., Stuart, M. J., … Horning, S. J. (2001). Phase II trial of rituximab as adjuvant therapy to high dose chemotherapy and peripheral blood stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphomas. BLOOD, 98(11), 862A–862A. -
CD107 surface mobilization of peripheral blood T-cells to predict acute graft-versus-host disease
Baeuerlin, C. A., Brede, C., Riedel, S. S., Garrote, A. J., Kiesel, C., Ritz, M., … Beilhack, A. (2010). CD107 surface mobilization of peripheral blood T-cells to predict acute graft-versus-host disease. Presented at the 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, VIENNA,AUSTRIA: NATURE PUBLISHING GROUP. -
DIFFERENCES IN ALLOREACTIVE T CELL MIGRATION IN MHC MATCHED VERSUS MHC MISMATCHED HCT ARE CAUSED BY WAVES OF T CELL EXPANSION
Baeuerlein, C., Riedel, S., Brede, C., Garrote, A. L. J., Kiesel, C., Ritz, M., … Beilhack, A. (2010). DIFFERENCES IN ALLOREACTIVE T CELL MIGRATION IN MHC MATCHED VERSUS MHC MISMATCHED HCT ARE CAUSED BY WAVES OF T CELL EXPANSION. Presented at the 15th Annual Meeting of the European-Hematology-Association, BARCELONA,SPAIN: FERRATA STORTI FOUNDATION. -
Definition of a Diagnostic Window Prior to the Onset of Clinically Apparent Acute Graft-Versus-Host Disease
Baeuerlein, C. A., Riedel, S. S., Christian, B., Garrote, A.-L. J., Birner, A., Kiesel, C., … Beilhack, A. (2010). Definition of a Diagnostic Window Prior to the Onset of Clinically Apparent Acute Graft-Versus-Host Disease. BLOOD, 116(21), 1536–37. -
Mapping immune processes in intact tissues at cellular resolution
Brede, C., Friedrich, M., Jordan-Garrote, A.-L., Riedel, S. S., Baeuerlein, C. A., Heinze, K. G., … Beilhack, A. (2012). Mapping immune processes in intact tissues at cellular resolution. JOURNAL OF CLINICAL INVESTIGATION, 122(12), 4439–46. -
Use of R-spondin1, An Intestinotrophic Mitogen, in the Treatment of Murine Graft-Versus-Host Disease
Zambricki, E. A., Ootani, A., Mancuso, M. R., Zeiser, R., Kuo, C. J., & Negrin, R. S. (2008). Use of R-spondin1, An Intestinotrophic Mitogen, in the Treatment of Murine Graft-Versus-Host Disease. BLOOD, 112(11), 1206–. -
SINGLE DOSE ADMINISTRATION OF ECP TREATED CELLS PRIOR TO TRANSPLANTATION SIGNIFICANTLY INCREASES SURVIVAL IN A MHC-MISMATCHED MODEL OF ACUTE GVHD
Florek, M., Sega, E. I., Leveson-Gower, D. B., Gill, S., Mueller, A. M. S., & Negrin, R. S. (2011). SINGLE DOSE ADMINISTRATION OF ECP TREATED CELLS PRIOR TO TRANSPLANTATION SIGNIFICANTLY INCREASES SURVIVAL IN A MHC-MISMATCHED MODEL OF ACUTE GVHD. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(2), S337–S338. -
Early treatment with CD4+ CD25+ regulatory T cells provides prolonged suppressive effects which control evolving but not established graft-versus-host-disease.
Nguyen, V. H., Zeiser, R., Dasilva, D., Contag, C. N., & Negrin, R. S. (2005). Early treatment with CD4+ CD25+ regulatory T cells provides prolonged suppressive effects which control evolving but not established graft-versus-host-disease. BLOOD, 106(11), 379A–379A. -
Enhanced immune reconstitution and function by CD4+CD25+ regulatory T cells following allogeneic hematopoietic cell transplantation.
Nguyen, V. H., Shashidhar, S., Zeiser, R., Ho, L., Brown, J. M. Y., & Negrin, R. S. (2005). Enhanced immune reconstitution and function by CD4+CD25+ regulatory T cells following allogeneic hematopoietic cell transplantation. BLOOD, 106(11), 23A–23A. -
In vivo trafficking of CD4+CD25+ regulatory T-cells in allogeneic recipients using bioluminescence imaging.
Nguyen, V. H., Wieland, C., Contag, C., & Negrin, R. S. (2004). In vivo trafficking of CD4+CD25+ regulatory T-cells in allogeneic recipients using bioluminescence imaging. BLOOD, 104(11), 90A–90A. -
CD4+CD25+ Regulatory T cells enhance immune reconstitution following allogeneic hematopoietic cell transplantation by protecting thymic and lymphoid compartments from graft-versus-host disease damage without impacting T cell repertoire development.
Nguyen, V. H., Chang, D., Shashidhar, S., Bachmann, M., Contag, C. H., Brown, J. M. Y., & Negrin, R. S. (2006). CD4+CD25+ Regulatory T cells enhance immune reconstitution following allogeneic hematopoietic cell transplantation by protecting thymic and lymphoid compartments from graft-versus-host disease damage without impacting T cell repertoire development. BLOOD, 108(11), 25A–25A. -
Allogeneic environment and tissue damage provide critical stimuli for regulatory T cell expansion and survival in vivo after hematopoietic cell transplantation.
Nguyen, V. H., Chang, D., & Negrin, R. S. (2006). Allogeneic environment and tissue damage provide critical stimuli for regulatory T cell expansion and survival in vivo after hematopoietic cell transplantation. BLOOD, 108(11), 491A–491A. -
The apoptotic and proliferative fate of cytokine-induced killer cells after redirection to tumor cells with bispecific Ab
Kornacker, M., Verneris, M. R., Kornacker, B., Ganten, T. M., Scheffold, C., & Negrin, R. S. (2006). The apoptotic and proliferative fate of cytokine-induced killer cells after redirection to tumor cells with bispecific Ab. CYTOTHERAPY, 8(1), 13–23. -
Activated T cells and cytokine-induced CD3(+)CD56(+) killer cells
SCHMIDTWOLF, G. D., Negrin, R. S., & SCHMIDTWOLF, I. G. H. (1997). Activated T cells and cytokine-induced CD3(+)CD56(+) killer cells. ANNALS OF HEMATOLOGY, 74(2), 51–56. -
Salvage Allogeneic Hematopoietic Cell Transplantation with Fludarabine and Low-Dose Total Body Irradiation after Rejection of First Allografts
Gyurkocza, B., Cao, T. M., Storb, R. F., Lange, T., Leisenring, W., Franke, G. N., … Sandmaier, B. M. (2009). Salvage Allogeneic Hematopoietic Cell Transplantation with Fludarabine and Low-Dose Total Body Irradiation after Rejection of First Allografts. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 15(10), 1314–22. -
The Expansion of Gastrointestinal-associated alpha beta T Cell Clones in Peripheral Blood Over Time Is a Disease Feature of Severe Acute Graft-Versus-Host Disease
Meyer, E. H., Liliental, J., Florek, M., Loehr, A., Hsu, A., Johnson, D. S., … Negrin, R. S. (2012). The Expansion of Gastrointestinal-associated alpha beta T Cell Clones in Peripheral Blood Over Time Is a Disease Feature of Severe Acute Graft-Versus-Host Disease. BLOOD. ATLANTA,GA,GA,GA,GA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
The Expansion of Gastrointestinal-Associated alpha beta T Cell Clones in Peripheral Blood Associates with Severe Steroid Refractory GVHD
Meyer, E. H., Liliental, J. A., Florek, M., Lohr, A., Hsu, A., Johnson, D., … Negrin, R. (2013). The Expansion of Gastrointestinal-Associated alpha beta T Cell Clones in Peripheral Blood Associates with Severe Steroid Refractory GVHD. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. SALT LAKE CITY,UT,UT,UT,UT,UT,UT,UT,UT,UT: ELSEVIER SCIENCE INC. -
Bioluminescent imaging of human leukemic stem cell engraftment.
Jamieson, C., Karimi, M., Creusot, R., Negrin, R., Gotlib, J., Chao, M., … Weissman, I. L. (2005). Bioluminescent imaging of human leukemic stem cell engraftment. BLOOD, 106(11), 205A–205A. -
In vivo dynamics of hematopoietic reconstitution from purified stem and progenitor cells.
Wagers, A. J., Cao, Y. A., Beilhack, A., Dusich, J., Bachmann, M. H., Negrin, R. S., … Contag, C. H. (2003). In vivo dynamics of hematopoietic reconstitution from purified stem and progenitor cells. BLOOD. SAN DIEGO,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA: AMER SOC HEMATOLOGY. -
Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation
Guerrero, A., Riddell, S. R., Storek, J., Stevens-Ayers, T., Storer, B., Zaia, J. A., … Boeckh, M. (2012). Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 18(1), 66–75. -
Regulation of different inflammatory diseases by impacting the mevalonate pathway
Zeiser, R., Maas, K., Youssef, S., Duerr, C., Steinman, L., & Negrin, R. S. (2009). Regulation of different inflammatory diseases by impacting the mevalonate pathway. IMMUNOLOGY, 127(1), 18–25. -
Innovation - In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease
Negrin, R. S., & Contag, C. H. (2006). Innovation - In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease. NATURE REVIEWS IMMUNOLOGY, 6(6), 484–U2. -
Total lymphoid irradiation and transplantation tolerance
Lowsky, R., & Negrin, R. S. (2006). Total lymphoid irradiation and transplantation tolerance. CURRENT OPINION IN ORGAN TRANSPLANTATION, 11(1), 54–61. -
Promise and challenges of human regulatory T cells in the clinic
Negrin, R. S., & Hou, J.-Z. (2007). Promise and challenges of human regulatory T cells in the clinic. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 13(1), 12–16. -
EFFICIENT GENERATION AND CHARACTERIZATION OF TUMOR-CELL SUBCLONES WITH DIFFERENT ADHESION PATHWAYS INVOLVED IN CELL-LYSIS
Lefterova, P., Negrin, R., Neubauer, A., Huhn, D., Blume, K., & SCHMIDTWOLF, I. (1993). EFFICIENT GENERATION AND CHARACTERIZATION OF TUMOR-CELL SUBCLONES WITH DIFFERENT ADHESION PATHWAYS INVOLVED IN CELL-LYSIS. HAEMATOLOGICA, 78(6), 353–58. -
Cellular immunotherapy and autologous transplantation for hematologic malignancy
Margolin, K. A., Negrin, R. S., Wong, K. K., Chatterjee, S., Wright, C., & Forman, S. J. (1997). Cellular immunotherapy and autologous transplantation for hematologic malignancy. IMMUNOLOGICAL REVIEWS, 157, 231–40. -
The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia
Oehler, V. G., Gooley, T., Snyder, D. S., Johnston, L., Lin, A., Cummings, C. C., … Radich, J. P. (2007). The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia. BLOOD, 109(4), 1782–89. -
Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis
Kornacker, M., Schlattner, U., Wallimann, T., Verneris, M. R., Negrin, R. S., Kornacker, B., … Wolf, J. (2001). Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis. INTERNATIONAL JOURNAL OF CANCER, 94(4), 513–19. -
A multicenter study of platelet recovery and utilization in patients after myeloablative therapy and hematopoietic stem cell transplantation
Bernstein, S. H., Nademanee, A. P., Vose, J. M., Tricot, G., Fay, J. W., Negrin, R. S., … Nash, R. A. (1998). A multicenter study of platelet recovery and utilization in patients after myeloablative therapy and hematopoietic stem cell transplantation. BLOOD, 91(9), 3509–3517. -
THALIDOMIDE AS SALVAGE THERAPY FOR CHRONIC GRAFT-VERSUS-HOST DISEASE
Parker, P. M., Chao, N., Nademanee, A., ODONNELL, M. R., Schmidt, G. M., Snyder, D. S., … Forman, S. J. (1995). THALIDOMIDE AS SALVAGE THERAPY FOR CHRONIC GRAFT-VERSUS-HOST DISEASE. BLOOD, 86(9), 3604–9. -
A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation
Nash, R. A., Kurzrock, R., DiPersio, J., Vose, J., Linker, C., Maharaj, D., … Champlin, R. (2000). A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 6(1), 25–34. -
Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells
Zangi, L., Margalit, R., Reich-Zeliger, S., Bachar-Lustig, E., Beilhack, A., Negrin, R., & Reisner, Y. (2009). Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells. STEM CELLS, 27(11), 2865–74. -
Interleukin-2 receptor downstream events in regulatory T cells - Implications for the choice of immunosuppressive drug therapy
Zeiser, R., & Negrin, R. S. (2008). Interleukin-2 receptor downstream events in regulatory T cells - Implications for the choice of immunosuppressive drug therapy. CELL CYCLE, 7(4), 458–62. -
A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells
Lask, A., Ophir, E., Or-Geva, N., Cohen-Fredarow, A., Afik, R., Eidelstein, Y., … Reisner, Y. (2013). A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells. BLOOD, 121(15), 3033–40. -
Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia
Oehler, V. G., Radich, J. P., Storer, I., Blume, K. G., Chauncey, T., Clift, R., … Bensinger, W. (2005). Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 11(2), 85–92. -
Long-term outcomes after transplantation of HLA-identical related G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow
Mielcarek, M., Storer, B., Martin, P. J., Forman, S. J., Negrin, R. S., Flowers, M. E., … Bensinger, W. I. (2012). Long-term outcomes after transplantation of HLA-identical related G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow. BLOOD, 119(11), 2675–78. -
PROPAGATION OF LARGE NUMBERS OF T-CELLS WITH NATURAL-KILLER-CELL MARKERS
SCHMIDTWOLF, I. G. H., Lefterova, P., Johnston, V., Huhn, D., Blume, K. G., & Negrin, R. S. (1994). PROPAGATION OF LARGE NUMBERS OF T-CELLS WITH NATURAL-KILLER-CELL MARKERS. BRITISH JOURNAL OF HAEMATOLOGY, 87(3), 453–458. -
Erythroid response to treatment with G-CSF plus erythropoietin for the anaemia of patients with myelodysplastic syndromes: proposal for a predictive model
HELLSTROMLINDBERG, E., Negrin, R., Stein, R., Krantz, S., Lindberg, G., Vardiman, J., … Greenberg, P. (1997). Erythroid response to treatment with G-CSF plus erythropoietin for the anaemia of patients with myelodysplastic syndromes: proposal for a predictive model. BRITISH JOURNAL OF HAEMATOLOGY, 99(2), 344–51. -
Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells
Ophir, E., Or-Geva, N., Gurevich, I., Tal, O., Eidelstein, Y., Shezen, E., … Reisner, Y. (2013). Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells. BLOOD, 121(7), 1220–28. -
CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56(+) T cells
Lopez, R. D., Waller, E. K., Lu, P. H., & Negrin, R. S. (2001). CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56(+) T cells. CANCER IMMUNOLOGY IMMUNOTHERAPY, 49(12), 629–40. -
MUTATIONS IN THE RAS PROTOONCOGENES IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
Neubauer, A., Greenberg, P., Negrin, R., Ginzton, N., & Liu, E. (1994). MUTATIONS IN THE RAS PROTOONCOGENES IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES. LEUKEMIA, 8(4), 638–41. -
Mapping immune processes in intact tissues at cellular resolution.
Brede, C., Friedrich, M., Jordán-Garrote, A.-L., Riedel, S. S., Bäuerlein, C. A., Heinze, K. G., … Beilhack, A. (2012). Mapping immune processes in intact tissues at cellular resolution. Journal of Clinical Investigation, 122(12), 4439–4446. -
Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells
SCHMIDTWOLF, I. G. H., Lefterova, P., Johnston, V., Scheffold, C., Csipai, M., Mehta, B. A., … Negrin, R. S. (1996). Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells. CELLULAR IMMUNOLOGY, 169(1), 85–90. -
Evaluation of effector cell fate and function by in vivo bioluminescence imaging
Edinger, M., Hoffmann, P., Contag, C. H., & Negrin, R. S. (2003). Evaluation of effector cell fate and function by in vivo bioluminescence imaging. METHODS, 31(2), 172–79. -
Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers.
Bensinger, W. I., Martin, P. J., Storer, B., Clift, R., Forman, S. J., Negrin, R., … Blume, K. (2001). Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. NEW ENGLAND JOURNAL OF MEDICINE, 344(3), 175–81. -
A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model.
Bäuerlein, C. A., Riedel, S. S., Baker, J., Brede, C., Garrote, A.-L. J., Chopra, M., … Beilhack, A. (2013). A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model. BMC Medicine, 11, 134-? -
ISHAGE Scientific Committee Report - Assays to determine hematopoietic stem cell content in blood or marrow grafts
Verfaillie, C. M., Ploemacher, R., di Persio, J., Sutherland, R., Serke, S., Johnsen, H., … Negrin, R. (1999). ISHAGE Scientific Committee Report - Assays to determine hematopoietic stem cell content in blood or marrow grafts. CYTOTHERAPY, 1(1), 41–49. -
ANALYSIS OF HUMAN HEMATOPOIETIC STEM-CELL POPULATIONS
Murray, L., DiGiusto, D., Chen, B., Chen, S., Combs, J., Conti, A., … Tsukamoto, A. (1994). ANALYSIS OF HUMAN HEMATOPOIETIC STEM-CELL POPULATIONS. BLOOD CELLS, 20(2-3), 364–370. -
Assays to determine hematopoietic stem cell content in blood or marrow grafts.
Verfaillie, C. M., Ploemacher, R., di Persio, J., Sutherland, R., Serke, S., Johnsen, H., … Negrin, R. (1999). Assays to determine hematopoietic stem cell content in blood or marrow grafts. Cytotherapy, 1(1), 41–49. -
ENRICHMENT OF HUMAN HEMATOPOIETIC STEM-CELL ACTIVITY IN THE CD34(+)THY-1(+)LIN(-) SUBPOPULATION FROM MOBILIZED PERIPHERAL-BLOOD
Murray, L., Chen, B., Galy, A., Chen, S., Tushinski, R., Uchida, N., … Tsukamoto, A. (1995). ENRICHMENT OF HUMAN HEMATOPOIETIC STEM-CELL ACTIVITY IN THE CD34(+)THY-1(+)LIN(-) SUBPOPULATION FROM MOBILIZED PERIPHERAL-BLOOD. BLOOD, 85(2), 368–78. -
Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation.
Schneidawind, D., Pierini, A., & Negrin, R. S. (2013). Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation. Blood, 122(18), 3116–21. -
GENERATION OF T-CELLS FROM CYTOKINE-MOBILIZED PERIPHERAL-BLOOD AND ADULT BONE-MARROW CD34+ CELLS
Galy, A. H. M., Webb, S., CEN, D. H., Murray, L. J., CONDINO, J., Negrin, R. S., & Chen, B. P. (1994). GENERATION OF T-CELLS FROM CYTOKINE-MOBILIZED PERIPHERAL-BLOOD AND ADULT BONE-MARROW CD34+ CELLS. BLOOD, 84(1), 104–110. -
IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease after Bone Marrow Transplantation.
Colonna, L., Florek, M., Leveson-Gower, D. B., Sega, E. I., Baker, J., Smith, A. T., & Negrin, R. S. (2013). IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease after Bone Marrow Transplantation. Biology of Blood and Marrow Transplantation , 19(11), 1557–65. -
Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells.
Leveson-Gower, D. B., Sega, E. I., Kalesnikoff, J., Florek, M., Pan, Y., Pierini, A., … Negrin, R. S. (2013). Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Blood, 122(22), 3659–65. -
Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation.
Sega, E. I., Leveson-Gower, D. B., Florek, M., Schneidawind, D., Luong, R. H., & Negrin, R. S. (2014). Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation. PloS One, 9(1). -
Total lymphoid irradiation-antithymocyte globulin conditioning and allogeneic transplantation for patients with myelodysplastic syndromes and myeloproliferative neoplasms.
Benjamin, J., Chhabra, S., Kohrt, H. E., Lavori, P., Laport, G. G., Arai, S., … Lowsky, R. (2014). Total lymphoid irradiation-antithymocyte globulin conditioning and allogeneic transplantation for patients with myelodysplastic syndromes and myeloproliferative neoplasms. Biology of Blood and Marrow Transplantation , 20(6), 837–43. -
A killer choice for cancer immunotherapy.
Schmidt, T. L., Negrin, R. S., & Contag, C. H. (2014). A killer choice for cancer immunotherapy. Immunologic Research, 58(2-3), 300–306. -
Optimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes: Consensus Guidelines and Recommendations
Giralt, S., Costa, L., Schriber, J., DiPersio, J., Maziarz, R., McCarty, J., … Devine, S. (2014). Optimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes: Consensus Guidelines and Recommendations. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 20(3), 295–308. -
Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment.
Müller, A. M. S., Poyser, J., Küpper, N. J., Burnett, C., Ko, R. M., Kohrt, H. E. K., … Shizuru, J. A. (2014). Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment. Blood, 123(18), 2882–92. -
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida, P. E., Meyer, E. H., Kooreman, N. G., Diecke, S., Dey, D., Sanchez-Freire, V., … Wu, J. C. (2014). Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. Nature Communications, 5, 3903-? -
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
Zeng, Z., Shi, Y. X., Samudio, I. J., Wang, R.-Y., Ling, X., Frolova, O., … Konopleva, M. (2009). Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. BLOOD, 113(24), 6215–24. -
Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models.
Florek, M., Sega, E. I., Leveson-Gower, D. B., Baker, J., Müller, A. M. S., Schneidawind, D., … Negrin, R. S. (2014). Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models. Blood, 124(11), 1832–42. -
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida, P. E., Meyer, E. H., Kooreman, N. G., Diecke, S., Dey, D., Sanchez-Freire, V., … Wu, J. C. (2014). Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. Nature Communications, 5, 3903-? -
Role of lymphocyte activation gene-3 (lag-3) in conventional and regulatory T cell function in allogeneic transplantation.
Sega, E. I., Leveson-Gower, D. B., Florek, M., Schneidawind, D., Luong, R. H., & Negrin, R. S. (2014). Role of lymphocyte activation gene-3 (lag-3) in conventional and regulatory T cell function in allogeneic transplantation. PloS One, 9(1). -
Alloreactive T-cell trafficking after hematopoietic stem cell transplantation.
Beilhack, A., Schulz, S., Baker, J., Beilhack, G., Herman, E., Baker, E., … Negrin, R. (2007). Alloreactive T-cell trafficking after hematopoietic stem cell transplantation. Journal of Stem Cells & Regenerative Medicine, 2(1), 17-? -
Alloreactive T-cell trafficking after hematopoietic stem cell transplantation.
Beilhack, A., Schulz, S., Baker, J., Beilhack, G., Herman, E., Baker, E., … Negrin, R. (2007). Alloreactive T-cell trafficking after hematopoietic stem cell transplantation. Journal of Stem Cells & Regenerative Medicine, 2(1), 107-? -
Treatment of 4T1 Metastatic Breast Cancer with Combined Hypofractionated Irradiation and Autologous T-Cell Infusion.
Filatenkov, A., Baker, J., Müller, A. M., Ahn, G.-O., Kohrt, H., Dutt, S., … Strober, S. (2014). Treatment of 4T1 Metastatic Breast Cancer with Combined Hypofractionated Irradiation and Autologous T-Cell Infusion. Radiation Research, 182(2), 163–69. -
CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells
Schneidawind, D., Pierini, A., Alvarez, M., Pan, Y., Baker, J., Buechele, C., … Negrin, R. S. (2014). CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells. BLOOD. -
CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells.
Schneidawind, D., Pierini, A., Alvarez, M., Pan, Y., Baker, J., Buechele, C., … Negrin, R. S. (2014). CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells. Blood, 124(22), 3320–28. -
Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models
Florek, M., Sega, E. I., Leveson-Gower, D. B., Baker, J., Mueller, A. M. S., Schneidawind, D., … Negrin, R. S. (2014). Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models. BLOOD, 124(11), 1832–42. -
Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays
Sadaghiani, A. M., Lee, S. M., Odegaard, J. I., Leveson-Gower, D. B., McPherson, O. M., Novick, P., … Park, C. Y. (2014). Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays. CHEMISTRY & BIOLOGY, 21(10), 1278–92. -
European LeukemiaNet classification intermediate risk-1 cohort is associated with poor outcomes in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation
Medeiros, B. C., Tian, L., Robenson, S., Laport, G. G., JOHNSTON, L. J., Shizuru, J. A., … Lowsky, R. (2014). European LeukemiaNet classification intermediate risk-1 cohort is associated with poor outcomes in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. BLOOD CANCER JOURNAL, 4. -
Third-party CD4(+) invariant natural killer T cells protect from murine GVHD lethality
Schneidawind, D., Baker, J., Pierini, A., Buechele, C., Luong, R. H., Meyer, E. H., & Negrin, R. S. (2015). Third-party CD4(+) invariant natural killer T cells protect from murine GVHD lethality. BLOOD, 125(22), 3491–3500. -
Engraftment of Embryonic Stem Cells and Differentiated Progeny by Host Conditioning with Total Lymphoid Irradiation and Regulatory T Cells
Pan, Y., Leveson-Gower, D. B., de Almeida, P. E., Pierini, A., Baker, J., Florek, M., … Negrin, R. S. (2015). Engraftment of Embryonic Stem Cells and Differentiated Progeny by Host Conditioning with Total Lymphoid Irradiation and Regulatory T Cells. CELL REPORTS, 10(11), 1793–1802. -
ABO Mismatch Is Associated with Increased Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation
Logan, A. C., Wang, Z., Alimoghaddam, K., Wong, R. M., Lai, T., Negrin, R. S., … Miklos, D. B. (2015). ABO Mismatch Is Associated with Increased Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21(4), 746–54. -
Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease
Pierini, A., Colonna, L., Alvarez, M., Schneidawind, D., Nishikii, H., Baker, J., … Negrin, R. S. (2015). Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease. JOURNAL OF IMMUNOLOGY, 195(1), 347–55. -
Allogeneic hematopoietic cell transplant for normal karyotype AML: indirect evidence of selection for adverse molecular profile.
Percival, M.-E. M., Medeiros, B. C., Tian, L., Robeson, S., Laport, G. G., Johnston, L. J., … Lowsky, R. (2015). Allogeneic hematopoietic cell transplant for normal karyotype AML: indirect evidence of selection for adverse molecular profile. Bone Marrow Transplantation. -
Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease.
Kim, B.-S., Nishikii, H., Baker, J., Pierini, A., Schneidawind, D., Pan, Y., … Negrin, R. S. (2015). Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease. Blood, 126(4), 546–57. -
Unipotent Megakaryopoietic Pathway Bridging Hematopoietic Stem Cells and Mature Megakaryocytes
Nishikii, H., Kanazawa, Y., Umemoto, T., Goltsev, Y., Matsuzaki, Y., Matsushita, K., … Chiba, S. (2015). Unipotent Megakaryopoietic Pathway Bridging Hematopoietic Stem Cells and Mature Megakaryocytes. STEM CELLS, 33(7), 2196–2207. -
Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions.
Filatenkov, A., Baker, J., Mueller, A. M. S., Kenkel, J., Ahn, G.-O., Dutt, S., … Strober, S. (2015). Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions. Clinical Cancer Research , 21(16), 3727–39. -
Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays.
Sadaghiani, A. M., Lee, S. M., Odegaard, J. I., Leveson-Gower, D. B., McPherson, O. M., Novick, P., … Park, C. Y. (2014). Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays. Chemistry & Biology, 21(10), 1278–92. -
Leukemic burden in subpopulations of CD34(+) cells isolated from the mobilized peripheral blood of alpha-interferon-resistant or -intolerant patients with chronic myeloid leukemia
Vandenberg, D., WESSMAN, M., Murray, L., Tong, J., Chen, B., Chen, S., … Hoffman, R. (1996). Leukemic burden in subpopulations of CD34(+) cells isolated from the mobilized peripheral blood of alpha-interferon-resistant or -intolerant patients with chronic myeloid leukemia. BLOOD, 87(10), 4348–57. -
Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease
Kurnellas, M. P., Ghosn, E. E. B., Schartner, J. M., Baker, J., Rothbard, J. J., Negrin, R. S., … Rothbard, J. B. (2015). Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(49), 15016–23. -
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.
Buechele, C., Breese, E. H., Schneidawind, D., Lin, C.-H., Jeong, J., Duque-Afonso, J., … Cleary, M. L. (2015). MLL leukemia induction by genome editing of human CD34+ hematopoietic cells. Blood, 126(14), 1683–94. -
Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization.
Kuipers, H. F., Rieck, M., Gurevich, I., Nagy, N., Butte, M. J., Negrin, R. S., … Bollyky, P. L. (2016). Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. Proceedings of the National Academy of Sciences of the United States of America. -
Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy.
Nakasone, H., Remberger, M., Tian, L., Brodin, P., Sahaf, B., Wu, F., … Meyer, E. (2015). Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy. Haematologica, 100(11), 1477–85. -
Allogeneic hematopoietic cell transplantation after failed autologous transplant for lymphoma using TLI and anti-thymocyte globulin conditioning
Rezvani, A. R., Kanate, A. S., Efron, B., Chhabra, S., Kohrt, H. E., Shizuru, J. A., … Lowsky, R. (2015). Allogeneic hematopoietic cell transplantation after failed autologous transplant for lymphoma using TLI and anti-thymocyte globulin conditioning. BONE MARROW TRANSPLANTATION, 50(10), 1286–92. -
Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization.
Kuipers, H. F., Rieck, M., Gurevich, I., Nagy, N., Butte, M. J., Negrin, R. S., … Bollyky, P. L. (2016). Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1339–44. -
Freeze and Thaw of CD4(+) CD25(+) Foxp3(+) Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease
Florek, M., Schneidawind, D., Pierini, A., Baker, J., Armstrong, R., Pan, Y., … Meyer, E. (2015). Freeze and Thaw of CD4(+) CD25(+) Foxp3(+) Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease. PLOS ONE, 10(12). -
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
Zeiser, R., Burchert, A., Lengerke, C., Verbeek, M., Maas-Bauer, K., Metzelder, S. K., … von Bubnoff, N. (2015). Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. LEUKEMIA, 29(10), 2062–2068. -
Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.
Pierini, A., Schneidawind, D., Nishikii, H., & Negrin, R. S. (2015). Regulatory T Cell Immunotherapy in Immune-Mediated Diseases. Current Stem Cell Reports, 1(4), 177–86. -
NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell Engraftment.
Pierini, A., Alvarez, M., & Negrin, R. S. (2016). NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell Engraftment. Stem Cells International, 2016, 9025835-? -
Graft-versus-host disease versus graft-versus-leukemia
Negrin, R. S. (2015). Graft-versus-host disease versus graft-versus-leukemia. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 225–30. -
TNF-a priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment.
Pierini, A., Strober, W., Moffett, C., Baker, J., Nishikii, H., Alvarez, M., … Negrin, R. S. (2016). TNF-a priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment. Blood, 128(6), 866–71. -
DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease.
Nishikii, H., Kim, B.-S., Yokoyama, Y., Chen, Y., Baker, J., Pierini, A., … Negrin, R. S. (2016). DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease. Blood. -
A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease
Meyer, E. H., Hsu, A. R., Liliental, J., Loehr, A., Florek, M., Zehnder, J. L., … Negrin, R. S. (2013). A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease. BLOOD, 121(24), 4955–62. -
FRACTIONATED TOTAL-BODY IRRADIATION AND HIGH-DOSE ETOPOSIDE AS A PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR 99 PATIENTS WITH ACUTE-LEUKEMIA IN 1ST COMPLETE REMISSION
Snyder, D. S., Chao, N. J., Amylon, M. D., Taguchi, J., Long, G. D., Negrin, R. S., … Blume, K. G. (1993). FRACTIONATED TOTAL-BODY IRRADIATION AND HIGH-DOSE ETOPOSIDE AS A PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR 99 PATIENTS WITH ACUTE-LEUKEMIA IN 1ST COMPLETE REMISSION. BLOOD, 82(9), 2920–28. -
Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment.
Müller, A. M. S., Poyser, J., Küpper, N. J., Burnett, C., Ko, R. M., Kohrt, H. E. K., … Shizuru, J. A. (2014). Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment. Blood, 123(18), 2882–92. -
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Müller, A. M. S., Florek, M., Kohrt, H. E. K., Küpper, N. J., Filatenkov, A., Linderman, J. A., … Shizuru, J. A. (2016). Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning. Journal of Immunology , 197(10), 4151–62. -
Introduction to a review series: Chronic GVHD - from pathogenic BCR signaling to novel therapeutic targets.
Zeiser, R., & Negrin, R. S. (2016). Introduction to a review series: Chronic GVHD - from pathogenic BCR signaling to novel therapeutic targets. Blood. -
Mouse models of bone marrow transplantation
Reddy, P., Negrin, R., & Hill, G. R. (2008). Mouse models of bone marrow transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14(1), 129–35. -
Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation
Simonetta, F., Alvarez, M., & Negrin, R. S. (2017). Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation. FRONTIERS IN IMMUNOLOGY, 8. -
Regulatory T Cells and Decreased Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation in Patients Receiving Sirolimus and RGI-2001, an Activator of Invariant Natural Killer T Cells.
Chen, Y.-B., Efebera, Y. A., Johnston, L., Ball, E. D., Avigan, D., Lekakis, L. J., … Bui, J. D. (2017). Regulatory T Cells and Decreased Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation in Patients Receiving Sirolimus and RGI-2001, an Activator of Invariant Natural Killer T Cells. Biology of Blood and Marrow Transplantation . -
Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
Pierini, A., Nishikii, H., Baker, J., Kimura, T., Kwon, H.-S., Pan, Y., … Negrin, R. S. (2017). Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. NATURE COMMUNICATIONS, 8. -
Increased Foxp3(+)Helios(+) Regulatory T Cells and Decreased Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation in Patients Receiving Sirolimus and RGI-2001, an Activator of Invariant Natural Killer T Cells
Chen, Y.-B., Efebera, Y. A., Johnston, L., Ball, E. D., Avigan, D., Lekakis, L. J., … Bui, J. D. (2017). Increased Foxp3(+)Helios(+) Regulatory T Cells and Decreased Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation in Patients Receiving Sirolimus and RGI-2001, an Activator of Invariant Natural Killer T Cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 23(4), 625–34. -
A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.
Ronald, J. A., Kim, B.-S., Gowrishankar, G., Namavari, M., Alam, I. S., D'Souza, A., … Gambhir, S. S. (2017). A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant. Cancer Research, 77(11), 2893–2902. -
Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells.
Du, J., Paz, K., Thangavelu, G., Schneidawind, D., Baker, J., Flynn, R., … Blazar, B. R. (2017). Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells. Blood. -
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation
Ruggeri, L., Capanni, M., Casucci, M., Volpi, I., Tosti, A., Perruccio, K., … Velardi, A. (1999). Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. BLOOD, 94(1), 333–39. -
T cells expressing chimeric antigen receptor promote immune tolerance.
Pierini, A., Iliopoulou, B. P., Peiris, H., Pérez-Cruz, M., Baker, J., Hsu, K., … Meyer, E. H. (2017). T cells expressing chimeric antigen receptor promote immune tolerance. JCI Insight, 2(20). -
HLA-mismatched unrelated donor transplantation using TLI-ATG conditioning has a low risk of GVHD and potent antitumor activity.
Spinner, M. A., Fernández-Viña, M., Creary, L. E., Quinn, O., Elder, L., Arai, S., … Rezvani, A. R. (2017). HLA-mismatched unrelated donor transplantation using TLI-ATG conditioning has a low risk of GVHD and potent antitumor activity. Blood Advances, 1(17), 1347–57. -
Memory Phenotype CD8+T Cells Are Superior to Naive CD8+T Cells in Separating Graft Anti-Tumor Activity From Gvhd After Bone Marrow Transplantation; Application to DLI.
Dutt, S., Baker, J., Kambham, N., Kohrt, H. E., Negrin, R., & Strober, S. (2009). Memory Phenotype CD8+T Cells Are Superior to Naive CD8+T Cells in Separating Graft Anti-Tumor Activity From Gvhd After Bone Marrow Transplantation; Application to DLI. BLOOD, 114(22), 967. -
Long-Term Outcomes of AML Patients Using Total Lymphoid Irradiation with Anti-Thymocyte Globulin
Nakasone, H., Miklos, D. B., Meyer, E., Rezvani, A., Muffly, L., Weng, W.-K., … Lowsky, R. (2016). Long-Term Outcomes of AML Patients Using Total Lymphoid Irradiation with Anti-Thymocyte Globulin. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Donor-Derived CIK Cell Infusion As Consolidative Therapy after Non-Myeloablative Allogeneic Transplant in Patients with Myeloid Neoplasms
Narayan, R., Benjamin, J., Laport, G., Tian, L., Tate, K., Elder, L., … Meyer, E. (2015). Donor-Derived CIK Cell Infusion As Consolidative Therapy after Non-Myeloablative Allogeneic Transplant in Patients with Myeloid Neoplasms. BLOOD. AMER SOC HEMATOLOGY. -
Infusion of donor-derived CD8(+) memory T cells for relapse following allogeneic hematopoietic cell transplantation
Muffly, L., Sheehan, K., Armstrong, R., Jensen, K., Tate, K., Rezvani, A. R., … Lowsky, R. (2018). Infusion of donor-derived CD8(+) memory T cells for relapse following allogeneic hematopoietic cell transplantation. BLOOD ADVANCES, 2(6), 681–90. -
Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects against lethal acute graft versus host disease.
Dutt, S., Ermann, J., Hoffmann, P., Edinger, M., Negrin, R. S., Fathman, C. G., & Strober, S. (2003). Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects against lethal acute graft versus host disease. BLOOD, 102(11), 950A. -
Mast Cells Reduce Gvhd Severity In Allogeneic Transplantation by Reducing the Proliferation of Conventional T Cells
Leveson-Gower, D. B., Sega, E. I., Kalesnikoff, J., Florek, M., Galli, S. J., & Negrin, R. (2010). Mast Cells Reduce Gvhd Severity In Allogeneic Transplantation by Reducing the Proliferation of Conventional T Cells. BLOOD, 116(21), 112. -
Cancer Vaccines and T Cell Therapy (vol 19, pg S97, 2013)
Rezvani, K., Brody, J. D., Kohrt, H. E., Logan, A. C., Advani, R., Czerwinski, D. K., … Barrett, J. (2013). Cancer Vaccines and T Cell Therapy (vol 19, pg S97, 2013). BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19(10), 1530. -
Phase I/II Clinical Trial of CpG-Activated Whole Cell Vaccine in Mantle Cell Lymphoma (MCL): Results in Safety and Efficacy from Planned Interim Analysis
Chu, M. P., Brody, J., Kohrt, H. E., Frank, M. J., Khodadoust, M., Reddy, S., … Levy, R. (2015). Phase I/II Clinical Trial of CpG-Activated Whole Cell Vaccine in Mantle Cell Lymphoma (MCL): Results in Safety and Efficacy from Planned Interim Analysis. BLOOD. AMER SOC HEMATOLOGY. -
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Mathew, N. R., Baumgartner, F., Braun, L., O'Sullivan, D., Thomas, S., Waterhouse, M., … Zeiser, R. (2018). Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. NATURE MEDICINE, 24(3), 282-+. -
Invariant Natural Killer T Cells As Suppressors of Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation.
Mavers, M., Maas-Bauer, K., & Negrin, R. S. (2017). Invariant Natural Killer T Cells As Suppressors of Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 8, 900. -
Cytotoxicity of human CD8+T-cells and NK-cells is suppressed by an alternative NKG2D splice variant
Karimi, M. A., Bachmann, M. H., Cao, T. M., Wang, C., Kim, E., Watts, T. H., … Zhang, L. (2009). Cytotoxicity of human CD8+T-cells and NK-cells is suppressed by an alternative NKG2D splice variant. JOURNAL OF IMMUNOLOGY. AMER ASSOC IMMUNOLOGISTS. -
Karl Georg Blume, MD In Memoriam
Forman, S. J., Negrin, R., & Chao, N. (2013). Karl Georg Blume, MD In Memoriam. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19(6), 845–46. -
IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease Following Bone Marrow Transplantation
Colonna, L., Florek, M., Leveson-Gower, D. B., Sega, E. I., Zeiser, R., Buess, M., & Negrin, R. S. (2011). IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease Following Bone Marrow Transplantation. BLOOD, 118(21), 1724. -
Treatment of Corticosteroid-Refractory Graft-Versus-Host Disease with Ruxolitinib in 95 Patients
Zeiser, R., Burchert, A., Lengerke, C., Verbeek, M., Maas-Bauer, K., Metzelder, S., … von Bubnoff, N. (2015). Treatment of Corticosteroid-Refractory Graft-Versus-Host Disease with Ruxolitinib in 95 Patients. BLOOD. AMER SOC HEMATOLOGY. -
Functional Comparison of Freshly Isolated and Ex-Vivo Expanded CD4(+)CD25(+)Foxp3(+) Regulatory T Cells in Suppressing Murine Acute GvHD
Sega, E. I., Leveson-Gower, D., Nguyen, V. H., & Negrin, R. (2008). Functional Comparison of Freshly Isolated and Ex-Vivo Expanded CD4(+)CD25(+)Foxp3(+) Regulatory T Cells in Suppressing Murine Acute GvHD. BLOOD, 112(11), 302. -
TNF-Alpha Priming Enhances CD4(+) FoxP3(+) Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment
Pierini, A., Moffett, C., Schneidawind, D., Baker, J., Nishikii, H., Pan, Y., … Negrin, R. (2015). TNF-Alpha Priming Enhances CD4(+) FoxP3(+) Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment. BLOOD. AMER SOC HEMATOLOGY. -
Non-Myeloablative Allogeneic Transplantation Resulting in Clinical and Molecular Remission with Low Non-Relapse Mortality (NRM) in Patients with Advanced Stage Mycosis Fungoides (MF) and Sezary Syndrome (SS)
Weng, W.-K., Armstrong, R., Arai, S., Johnston, L., Laport, G. G., Lowsky, R., … Kim, Y. H. (2014). Non-Myeloablative Allogeneic Transplantation Resulting in Clinical and Molecular Remission with Low Non-Relapse Mortality (NRM) in Patients with Advanced Stage Mycosis Fungoides (MF) and Sezary Syndrome (SS). BLOOD, 124(21). -
Expanded CD4+Foxp3+Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation
Nishikii, H., Kim, B.-S., Yokoyama, Y., Baker, J., Pierini, A., Alvarez, M., … Negrin, R. (2015). Expanded CD4+Foxp3+Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation. BLOOD, 126(23). -
Loss of CD62L Expression in CD4+FoxP3+Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models
Florek, M., Schneidawind, D., Baker, J., Pierini, A., Leveson-Gower, D. B., Pan, Y., … Meyer, E. H. (2014). Loss of CD62L Expression in CD4+FoxP3+Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models. BLOOD. AMER SOC HEMATOLOGY. -
Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells
Nishikii, H., Kim, B. S., Pierini, A., Baker, J., Schneidawind, D., Pan, Y., … Negrin, R. S. (2014). Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells. BLOOD, 124(21). -
Third Party Invariant Natural Killer T Cells Protect from Lethal Graft-Versus-Host Disease through Donor CD4+CD25+FoxP3+Regulatory T Cells
Schneidawind, D., Pierini, A., Baker, J., Buechele, C., Luong, R., Meyer, E., & Negrin, R. (2015). Third Party Invariant Natural Killer T Cells Protect from Lethal Graft-Versus-Host Disease through Donor CD4+CD25+FoxP3+Regulatory T Cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
TNF-Alpha Priming Enhances CD4+FoxP3+Regulatory T Cell Suppressive Function in GVHD Prevention and Treatment
Pierini, A., Strober, W. A., Moffett, C., Baker, J., Nishikii, H., Pan, Y., … Negrin, R. (2016). TNF-Alpha Priming Enhances CD4+FoxP3+Regulatory T Cell Suppressive Function in GVHD Prevention and Treatment. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Guide T Cell and Treg Homing for GvHD Control and Tissue Tolerance in Murine Models
Pierini, A., Iliopoulou, B. P., Baker, J., Peiris, H., Hsu, K., Kim, S., … Meyer, E. (2016). The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Guide T Cell and Treg Homing for GvHD Control and Tissue Tolerance in Murine Models. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Transplantation of Peripheral Blood Cells As Compared with Bone Marrow From HLA-Identical Related Donors Is Associated with Superior Long-Term Outcomes
Mielcarek, M., Storer, B., Martin, P. J., Negrin, R. S., Forman, S. J., Flowers, M. E. D., … Bensinger, W. I. (2011). Transplantation of Peripheral Blood Cells As Compared with Bone Marrow From HLA-Identical Related Donors Is Associated with Superior Long-Term Outcomes. BLOOD, 118(21), 149. -
Mesenchymal Stem Cells (MSC) Are Not Intrinsically Immune Privileged: Direct Demonstration in TCR Transgenic Mice and by Imaging of Allogeneic Luciferase plus MSC in Immune Competent Vs Immune Deficient Mice
Zangi, L., Beilhack, A., Negrin, R., Margalit, R., & Reisner, Y. (2008). Mesenchymal Stem Cells (MSC) Are Not Intrinsically Immune Privileged: Direct Demonstration in TCR Transgenic Mice and by Imaging of Allogeneic Luciferase plus MSC in Immune Competent Vs Immune Deficient Mice. BLOOD, 112(11), 205–6. -
Ex Vivo Generated Donor Central Memory CD8 T Cells, Previously Shown to Enhance Engraftment of Allogeneic Bone Marrow, Also Exhibit Significant GVL Activity without Causing Gvhd In An In Vivo b Cell Lymphoma Model
Lask, A., Ophir, E., Or-Geva, N., Cohen, A., Afik, R., Eidelstein, Y., … Reisner, Y. (2010). Ex Vivo Generated Donor Central Memory CD8 T Cells, Previously Shown to Enhance Engraftment of Allogeneic Bone Marrow, Also Exhibit Significant GVL Activity without Causing Gvhd In An In Vivo b Cell Lymphoma Model. BLOOD. AMER SOC HEMATOLOGY. -
Increased Activity in the T Cell Effector Phase and Enhanced T Cell Repertoire Target-Tissue Stability Distinguish Alloreactivity Across Major Versus Minor Histocompatibility Barriers
Zheng, P., Vasey, A. E., Baker, J., Iliopoulou, B., Leveson-Gower, D. B., Pierini, A., … Meyer, E. (2015). Increased Activity in the T Cell Effector Phase and Enhanced T Cell Repertoire Target-Tissue Stability Distinguish Alloreactivity Across Major Versus Minor Histocompatibility Barriers. BLOOD. AMER SOC HEMATOLOGY. -
CD4(+) Invariant Natural Killer T Cells Protect from Acute Graft-Versus-Host Disease Lethality through a Dramatic Expansion of Donor-Derived CD4(+)FoxP3(+) Regulatory T Cells
Schneidawind, D., Pierini, A., Alvarez, M., Pan, Y., Baker, J., Kim, B. S., … Negrin, R. (2014). CD4(+) Invariant Natural Killer T Cells Protect from Acute Graft-Versus-Host Disease Lethality through a Dramatic Expansion of Donor-Derived CD4(+)FoxP3(+) Regulatory T Cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Outcome of Tandem Autologous/Allogeneic Hematopoietic Cell Transplantation in High-Risk Non Hodgkin's Lymphoma Patients: Stanford University Experience
Wudhikarn, K., Lavori, P., Arai, S., Johnston, L., Laport, G. G., Lowsky, R., … Weng, W.-K. (2014). Outcome of Tandem Autologous/Allogeneic Hematopoietic Cell Transplantation in High-Risk Non Hodgkin's Lymphoma Patients: Stanford University Experience. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
CD4+FoxP3+Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts
Pierini, A., Nishikii, H., Pan, Y., Baker, J., Leveson-Gower, D. B., Florek, M., & Negrin, R. (2014). CD4+FoxP3+Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts. BLOOD, 124(21). -
UNIPOTENT MEGAKARYOPOIETIC PATHWAY BRIDGING HEMATOPOIETIC STEM CELLS AND MATURE MEGAKARYOCYTES
Nishikii, H., Umemoto, T., Goltsev, Y., Matsuzaki, Y., Yamato, M., Nolan, G., … Chiba, S. (2015). UNIPOTENT MEGAKARYOPOIETIC PATHWAY BRIDGING HEMATOPOIETIC STEM CELLS AND MATURE MEGAKARYOCYTES. EXPERIMENTAL HEMATOLOGY, 43(9), S85. -
Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index in Nonmyeloablative Allogeneic Stem Cell Transplantation
Veeraputhiran, M., Yang, L., Sundaram, V., Arai, S., Lowsky, R., Miklos, D., … Johnston, L. (2017). Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index in Nonmyeloablative Allogeneic Stem Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 23(10), 1744–48. -
NK cell reconstitution is improved during allogeneic hematopoietic stem cell transplantation by infusion of NK cell-committed progenitor cells
Alvarez, M., Pierini, A., Baker, J., & Negrin, R. (2015). NK cell reconstitution is improved during allogeneic hematopoietic stem cell transplantation by infusion of NK cell-committed progenitor cells. JOURNAL OF IMMUNOLOGY, 194. -
Impact of Donor T Cells on NK Cell Development after Allogeneic Hematopoietic Cell Transplantation
Alvarez, M., Pierini, A., Baker, J., & Negrin, R. (2016). Impact of Donor T Cells on NK Cell Development after Allogeneic Hematopoietic Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 22(3), S149–S150. -
CD4+FoxP3+Regulatory T Cells Promote B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts
Pierini, A., Nishikii, H., Pan, Y., Baker, J., Schneidawind, D., Alvarez, M., & Negrin, R. (2015). CD4+FoxP3+Regulatory T Cells Promote B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21(2), S71–S72. -
Immune Characterization of Ibrutinib Therapy Following Allohct That Provides GVL Benefit without Gvhd
Sahaf, B., Ryan, C. E., Rezvani, A., Nakasone, H., Otani, J., Coutre, S., … Miklos, D. B. (2016). Immune Characterization of Ibrutinib Therapy Following Allohct That Provides GVL Benefit without Gvhd. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Risks and Benefits of Sex-Mismatched Hematopoietic Cell Transplantation Differ By Conditioning Intensity
Nakasone, H., Remberger, M., Tian, L., Brodin, P., Sahaf, B., Wu, F., … Meyer, E. (2014). Risks and Benefits of Sex-Mismatched Hematopoietic Cell Transplantation Differ By Conditioning Intensity. BLOOD. AMER SOC HEMATOLOGY. -
Role of NKG2D in the induction of mouse natural killer cell exhaustion
Alvarez, M., & Negrin, R. (2014). Role of NKG2D in the induction of mouse natural killer cell exhaustion. JOURNAL OF IMMUNOLOGY, 192. -
Third Party Invariant Natural Killer T Cells Protect from Graft-Versus-Host Disease Lethality through Expansion of Donor CD4(+)FoxP3(+) Regulatory T Cells
Schneidawind, D., Baker, J., Buechele, C., Meyer, E. H., & Negrin, R. S. (2014). Third Party Invariant Natural Killer T Cells Protect from Graft-Versus-Host Disease Lethality through Expansion of Donor CD4(+)FoxP3(+) Regulatory T Cells. BLOOD. AMER SOC HEMATOLOGY. -
Risks and Benefits of Sex-Mismatched Hematopoietic Cell Transplantation Differ By Conditioning Strategy
Nakasone, H., Remberger, M., Tian, L., Brodin, P., Sahaf, B., Wu, F., … Meyer, E. (2015). Risks and Benefits of Sex-Mismatched Hematopoietic Cell Transplantation Differ By Conditioning Strategy. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
The Inhibitory Receptor LAG-3 Is Not Essential for Regulatory T Cells Function but Influences Donor T Cell Potency in Acute Graft-Versus-Host-Disease
Sega, E. I., Leveson-Gower, D. B., Florek, M., & Negrin, R. S. (2011). The Inhibitory Receptor LAG-3 Is Not Essential for Regulatory T Cells Function but Influences Donor T Cell Potency in Acute Graft-Versus-Host-Disease. BLOOD, 118(21), 829. -
Allogeneic Transplants from HLA-Mismatched Unrelated Donors Using Total Lymphoid Irradiation and Antithymocyte Globulin Conditioning Retain a Low Risk of Graft-Versus-Host Disease and Non-Relapse Mortality with at Least As Potent Anti-Tumor Activity As with Matched Unrelated Donors
Spinner, M. A., Vina, M. F., Elder, L., Arai, S., Johnston, L., Meyer, E., … Rezvani, A. R. (2016). Allogeneic Transplants from HLA-Mismatched Unrelated Donors Using Total Lymphoid Irradiation and Antithymocyte Globulin Conditioning Retain a Low Risk of Graft-Versus-Host Disease and Non-Relapse Mortality with at Least As Potent Anti-Tumor Activity As with Matched Unrelated Donors. BLOOD. AMER SOC HEMATOLOGY. -
Phase I Study of CD8 Memory T-Cell Donor Lymphocyte Infusion for Relapse of Hematologic Malignancies Following Matched Related Donor Allogeneic Hematopoietic Cell Transplantation
Muffly, L. S., Sheehan, K., Armstrong, R., Tate, K., Tudisco, C., Rezvani, A. R., … Lowsky, R. (2016). Phase I Study of CD8 Memory T-Cell Donor Lymphocyte Infusion for Relapse of Hematologic Malignancies Following Matched Related Donor Allogeneic Hematopoietic Cell Transplantation. BLOOD. AMER SOC HEMATOLOGY. -
Third party, umbilical cord blood derived regulatory T-cells for prevention of graft versus host disease in allogeneic hematopoietic stem cell transplantation: feasibility, safety and immune reconstitution.
Kellner, J. N., Delemarre, E. M., Yvon, E., Nierkens, S., Boelens, J. J., McNiece, I., … Parmar, S. (2018). Third party, umbilical cord blood derived regulatory T-cells for prevention of graft versus host disease in allogeneic hematopoietic stem cell transplantation: feasibility, safety and immune reconstitution. Oncotarget, 9(86), 35611–22. -
Nonmyeloablative Allogeneic Transplantation Using TLI-ATG Conditioning for Lymphoid and Myeloid Malignancies: Mature Follow-up from a Large, Single Institution Cohort
Spinner, M. A., Kennedy, V. E., Tamaresis, J. S., Lavori, P. W., Elder, L. V., Arai, S., … Lowsky, R. (2018). Nonmyeloablative Allogeneic Transplantation Using TLI-ATG Conditioning for Lymphoid and Myeloid Malignancies: Mature Follow-up from a Large, Single Institution Cohort. BLOOD. AMER SOC HEMATOLOGY. -
Tracking T Cell Activation By OX40 Immuno-PET: A Novel Strategy for Imaging of Graft Versus Host Disease
Simonetta, F., Alam, I. S., Mayer, A. T., Murty, S., Vermesh, O., Hirai, T., … Negrin, R. S. (2018). Tracking T Cell Activation By OX40 Immuno-PET: A Novel Strategy for Imaging of Graft Versus Host Disease. BLOOD. AMER SOC HEMATOLOGY. -
Elevated Axicabtagene Ciloleucel (CAR-19) Expansion By Immunophenotyping Is Associated with Toxicity in Diffuse Large B-Cell Lymphoma
Spiegel, J. Y., Sahaf, B., Hossain, N., Frank, M. J., Claire, G., Abramian, M., … Miklos, D. B. (2018). Elevated Axicabtagene Ciloleucel (CAR-19) Expansion By Immunophenotyping Is Associated with Toxicity in Diffuse Large B-Cell Lymphoma. BLOOD. AMER SOC HEMATOLOGY. -
Invariant Natural Killer T Cell Subsets Have Diverse Functions: iNKT2 and iNKT17 Protect from Graft-Versus-Host-Disease, Whereas iNKT1 Have Antitumor Potential
Maas-Bauer, K., Simonetta, F., Hirai, T., Wenokur, A., Fazal, F., Kambham, N., … Negrin, R. S. (2018). Invariant Natural Killer T Cell Subsets Have Diverse Functions: iNKT2 and iNKT17 Protect from Graft-Versus-Host-Disease, Whereas iNKT1 Have Antitumor Potential. BLOOD. AMER SOC HEMATOLOGY. -
A Proinflammatory Invariant Natural Killer T Cells Phenotypic State Associates with Human Graft-Versus-Host Disease Onset and Response
Erkers, T., Xei, B., Kenyon, L., Rieck, M., Basina, M., Jensen, K., … Meyer, E. H. (2018). A Proinflammatory Invariant Natural Killer T Cells Phenotypic State Associates with Human Graft-Versus-Host Disease Onset and Response. BLOOD, 132. -
Differential impact of host derived interleukin-18 on regulatory and conventional T cell expansion following murine allogeneic hematopoietic cell transplantation
Zeiser, R., Zambricki, E. A., Gower, D. B. L., Beilhack, A., Kambham, N., & Negrin, R. S. (2007). Differential impact of host derived interleukin-18 on regulatory and conventional T cell expansion following murine allogeneic hematopoietic cell transplantation. BLOOD, 110(11), 958A. -
NK cells induce alloreactive donor T cell apoptosis and decrease proliferation in GVHD induction
Olson, J. A., Leveson-Gower, D. B., Beilhack, A., & Negrin, R. S. (2007). NK cells induce alloreactive donor T cell apoptosis and decrease proliferation in GVHD induction. BLOOD, 110(11), 643A. -
Long term results of autologous hematopoietic cell transplantation (AHCT) for peripheral T cell lymphoma: The Stanford experience
Chen, A. I., McMillan, A., Negrin, R. S., Horning, S. J., & Laport, G. G. (2007). Long term results of autologous hematopoietic cell transplantation (AHCT) for peripheral T cell lymphoma: The Stanford experience. BLOOD. AMER SOC HEMATOLOGY. -
Selective expansion of human regulatory (CD4+CD25+CD12 7LowFOXP3+) cells to high purity by inhibiting expansion of CD4+CD25+CD127HighFOXP3-Conventional T cells with rapamycin.
Hou, J.-Z., Zambricki, E., Zeiser, R., & Negrin, R. S. (2006). Selective expansion of human regulatory (CD4+CD25+CD12 7LowFOXP3+) cells to high purity by inhibiting expansion of CD4+CD25+CD127HighFOXP3-Conventional T cells with rapamycin. BLOOD, 108(11), 902A–903A. -
Membranous glomerulonephritis and nephrotic syndrome as a late manifestation of chronic graft-versus-host reaction following allogeneic transplantation for hematologic malignancy.
Ahmad, B., Stehr, B., Johnston, L., Smith, E. P., Nademanee, A. P., Parker, P. M., … Forman, S. J. (2006). Membranous glomerulonephritis and nephrotic syndrome as a late manifestation of chronic graft-versus-host reaction following allogeneic transplantation for hematologic malignancy. BLOOD, 108(11), 819A–820A. -
Tissue-specific homing of natural killer cells in allogeneic bone marrow transplantation.
Olson, J. A., Zeiser, R., Beilhack, A., & Negrin, R. S. (2006). Tissue-specific homing of natural killer cells in allogeneic bone marrow transplantation. BLOOD, 108(11), 276A. -
Impact of mTOR inhibition on FoxP3+ regulatory T cells as compared to conventional T cells after allogeneic bone marrow transplantation.
Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., hou, J.-Z. H., & Negrin, R. (2006). Impact of mTOR inhibition on FoxP3+ regulatory T cells as compared to conventional T cells after allogeneic bone marrow transplantation. BLOOD, 108(11), 136A–137A. -
Trafficking and expansion of NK cells in murine models of bone marrow transplantation.
Olson, J. A., & Negrin, R. (2005). Trafficking and expansion of NK cells in murine models of bone marrow transplantation. BLOOD, 106(11), 672A. -
CD62L and CD31 matching are independent risk factors for survival after bone marrow transplantation.
Yu, W., Hiraki, D., Sequiera, J., Negrin, R., Grumet, F. C., & Lowsky, R. (2005). CD62L and CD31 matching are independent risk factors for survival after bone marrow transplantation. BLOOD, 106(11), 411A. -
The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models
Pierini, A., Iliopoulou, B., Peiris, H., Cruz, M. P., Baker, J., Hsu, K., … Meyer, E. (2016). The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models. BLOOD. AMER SOC HEMATOLOGY. -
DR3 Signaling Modulates the Function of Foxp3(+) regulatory T Cells and the Severity of Acute Graft and Host Disease
Nishikii, H., Byung-Su, K., Chen, Y., Baker, J., Pierini, A., Alvarez, M., … Negrin, R. S. (2016). DR3 Signaling Modulates the Function of Foxp3(+) regulatory T Cells and the Severity of Acute Graft and Host Disease. BLOOD, 128(22). -
A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease
Johnston, L., Armstrong, R., Baker, J., Sahaf, B., Otani, J., Tate, K., … Negrin, R. S. (2016). A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease. BLOOD. AMER SOC HEMATOLOGY. -
Foxp3(+) regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells
Nishikii, H., Pierini, A., Yokoyama, Y., Kimura, T., Kwon, H.-S., Alvarez, M., … Negrin, R. S. (2016). Foxp3(+) regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells. BLOOD. AMER SOC HEMATOLOGY. -
CD101 surface expression discriminates potency among murine FoxP3+regulatory T cells
Fernandez, I., Zeiser, R., Karsunky, H., Kambham, N., Beilhack, A., Sodestrom, K., … Engleman, E. (2007). CD101 surface expression discriminates potency among murine FoxP3+regulatory T cells. JOURNAL OF IMMUNOLOGY, 178. -
Analysis of expanded human cytokine induced killer cells for cellular therapy.
Baker, J., Sheehan, K., Monterola, G., Staines, N., & Negrin, R. S. (2005). Analysis of expanded human cytokine induced killer cells for cellular therapy. BLOOD, 106(11), 310A. -
Autologous stem cell transplantation for high-risk adult acute lymphomblastic leukemia (ALL).
Linker, C., Damon, L., Navarro, W., Ries, C., Negrin, R., Blume, K., … Forman, S. (2001). Autologous stem cell transplantation for high-risk adult acute lymphomblastic leukemia (ALL). BLOOD. AMER SOC HEMATOLOGY. -
Survivin expression is found preferentially in memory T-cells and correlates with apoptosis resistance after lymphocyte activation.
Kornacker, M., Verneris, M. R., Kornacker, B., Scheffold, C., & Negrin, R. S. (1999). Survivin expression is found preferentially in memory T-cells and correlates with apoptosis resistance after lymphocyte activation. BLOOD, 94(10), 8A. -
ESTABLISHMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML) IN SCID MICE
HOYLE, C., & NEGRIN, R. S. (1994). ESTABLISHMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML) IN SCID MICE. BLOOD, 84(10), A493. -
INTERLEUKIN-12 PROMOTES THE EXPANSION OF CD3+CD56+ KILLER-CELLS DERIVED FROM CD3+CD56- T-CELLS WITH ENHANCED CYTOTOXICITY
LU, P. H., & NEGRIN, R. S. (1994). INTERLEUKIN-12 PROMOTES THE EXPANSION OF CD3+CD56+ KILLER-CELLS DERIVED FROM CD3+CD56- T-CELLS WITH ENHANCED CYTOTOXICITY. BLOOD, 84(10), A289. -
MULTIPLE HIGH-DOSE CHEMOTHERAPY CYCLES SUPPORTED BY PERIPHERAL-BLOOD PROGENITOR CELLS AND G-CSF
CHAO, N. J., LONG, G. D., NEGRIN, R. S., KUZNIERZGLAS, C., & BLUME, K. G. (1993). MULTIPLE HIGH-DOSE CHEMOTHERAPY CYCLES SUPPORTED BY PERIPHERAL-BLOOD PROGENITOR CELLS AND G-CSF. BLOOD, 82(10), A349. -
GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION
SCHRIBER, CHAO, N. J., LONG, G. D., NEGRIN, R. S., & BLUME, K. G. (1993). GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION. BLOOD, 82(10), A286. -
A NEW PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR HODGKINS AND NON-HODGKINS-LYMPHOMA - CCNU (LOMUSTINE) ETOPOSIDE CYCLOPHOSPHAMIDE
CHAO, N. J., LONG, G. D., NEGRIN, R. S., & BLUME, K. G. (1993). A NEW PREPARATORY REGIMEN FOR BONE-MARROW TRANSPLANTATION FOR HODGKINS AND NON-HODGKINS-LYMPHOMA - CCNU (LOMUSTINE) ETOPOSIDE CYCLOPHOSPHAMIDE. BLOOD, 82(10), A143. -
Donor-derived CIK Cell Infusion as Consolidation after Non-myeloablative Allogeneic Transplant for Myeloid Neoplasms.
Narayan, R., Benjamin, J. E., Shah, O., Tian, L., Tate, K., Armstrong, R., … Meyer, E. H. (2019). Donor-derived CIK Cell Infusion as Consolidation after Non-myeloablative Allogeneic Transplant for Myeloid Neoplasms. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. -
Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease.
Pierini, A., Colonna, L., Alvarez, M., Schneidawind, D., Nishikii, H., Baker, J., … Negrin, R. S. (2015). Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease. Journal of Immunology (Baltimore, Md. : 1950). -
Graft-versus-host disease versus graft-versus-leukemia
Negrin, R. S. (2015). Graft-versus-host disease versus graft-versus-leukemia. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 225–30. -
Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients.
Meyer, E. H., Laport, G., Xie, B. J., MacDonald, K., Heydari, K., Sahaf, B., … Negrin, R. S. (2019). Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients. JCI Insight, 4(10). -
Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients
Meyer, E. H., Laport, G., Xie, B. J., MacDonald, K., Heydari, K., Sahaf, B., … Negrin, R. S. (2019). Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients. JCI INSIGHT, 4(10). -
Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway.
Alvarez, M., Simonetta, F., Baker, J., Pierini, A., Wenokur, A. S., Morrison, A. R., … Negrin, R. S. (2019). Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway. JCI Insight, 5. -
Prognostic score and cytogenetic risk classification for chronic lymphocytic leukemia patients: Center for International Blood and Marrow Transplant Research report.
Kim, H. T., Ahn, K. W., Hu, Z.-H. H., Davids, M. S., Volpe, V., Antin, J. H., … Brown, J. R. (2019). Prognostic score and cytogenetic risk classification for chronic lymphocytic leukemia patients: Center for International Blood and Marrow Transplant Research report. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Validation of the hematopoietic cell transplantation-specific comorbidity index in non-myeloablative allogeneic stem cell transplantation.
Veeraputhiran, M., Arai, S., Lowsky, R., Miklos, D. B., Meyer, E., Muffly, L. S., … Johnston, L. J. (2016). Validation of the hematopoietic cell transplantation-specific comorbidity index in non-myeloablative allogeneic stem cell transplantation. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Long-term outcomes of high-dose melphalan and carmustine followed by autologous hematopoietic cell transplantation for multiple myeloma.
Neppalli, A. K., Shizuru, J., Johnston, L. J., Muffly, L. S., Weng, W.-K., Negrin, R., … Rezvani, A. R. (2016). Long-term outcomes of high-dose melphalan and carmustine followed by autologous hematopoietic cell transplantation for multiple myeloma. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease
Mavers, M., Simonetta, F., Nishikii, H., Ribado, J., Maas-Bauer, K., Alvarez, M., … Negrin, R. S. (2019). Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease. FRONTIERS IN IMMUNOLOGY, 10. -
Donor-Derived Cytokine-Induced Killer Cell Infusion as Consolidation after Nonmyeloablative Allogeneic Transplantation for Myeloid Neoplasms
Narayan, R., Benjamin, J. E., Shah, O., Tian, L., Tate, K., Armstrong, R., … Meyer, E. H. (2019). Donor-Derived Cytokine-Induced Killer Cell Infusion as Consolidation after Nonmyeloablative Allogeneic Transplantation for Myeloid Neoplasms. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 25(7), 1293–1303. -
Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
Mavers, M., Simonetta, F., Nishikii, H., Ribado, J. V., Maas-Bauer, K., Alvarez, M., … Negrin, R. S. (2019). Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease. Frontiers in Immunology, 10, 1624. -
Nonmyeloablative TLI-ATG conditioning for allogeneic transplantation: mature follow-up from a large single-center cohort.
Spinner, M. A., Kennedy, V. E., Tamaresis, J. S., Lavori, P. W., Arai, S., Johnston, L. J., … Lowsky, R. (2019). Nonmyeloablative TLI-ATG conditioning for allogeneic transplantation: mature follow-up from a large single-center cohort. Blood Advances, 3(16), 2454–64. -
Immune regulation in hematopoietic cell transplantation.
Negrin, R. S. (2019). Immune regulation in hematopoietic cell transplantation. Bone Marrow Transplantation, 54(Suppl 2), 765–68. -
High-Parametric Evaluation of Human Invariant Natural Killer T Cells to Delineate Heterogeneity in Allo- and Autoimmunity.
Erkers, T., Xie, B., Kenyon, L. J., Smith, B., Rieck, M., Jensen, K. P., … Meyer, E. (2020). High-Parametric Evaluation of Human Invariant Natural Killer T Cells to Delineate Heterogeneity in Allo- and Autoimmunity. Blood. -
MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors.
Marschner, D., Falk, M., Javorniczky, N. R., Hanke-Muller, K., Rawluk, J., Schmitt-Graeff, A., … Kohler, N. (2020). MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors. JCI Insight. -
Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion.
Alvarez, M., Simonetta, F., Baker, J., Morrison, A. R., Wenokur, A. S., Pierini, A., … Negrin, R. S. (2020). Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion. Frontiers in Immunology, 11, 7. -
Regulatory T Cell Immunotherapy in Immune-Mediated Diseases
Pierini, A., Schneidawind, D., Nishikii, H., & Negrin, R. S. (2015). Regulatory T Cell Immunotherapy in Immune-Mediated Diseases. CURRENT STEM CELL REPORTS, 1(4), 177–86. -
Allogeneic Hematopoietic Cell Transplantation for Adult Acute Lymphoblastic Leukemia: Significant Increase in Survival in the Post-Targeted Immunotherapy Era
Muffly, L., Arai, S., Johnston, L., Lowsky, R., Meyer, E. H., Miklos, D. B., … Cunanan, K. (2020). Allogeneic Hematopoietic Cell Transplantation for Adult Acute Lymphoblastic Leukemia: Significant Increase in Survival in the Post-Targeted Immunotherapy Era. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Allogeneic Chimeric Antigen Receptor-Invariant Natural Killer T Cells Exert Both Direct and Indirect Antitumor Effects through Host CD8 T Cell Cross-Priming
Simonetta, F., Hirai, T., Lohmeyer, F. K., Maas-Bauer, K., Alvarez, M., Wenokur, A., … Negrin, R. S. (2020). Allogeneic Chimeric Antigen Receptor-Invariant Natural Killer T Cells Exert Both Direct and Indirect Antitumor Effects through Host CD8 T Cell Cross-Priming. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 26(3), S42. -
Engineered IL-2 Cytokine-Cytokine Receptor Complex Enables Selective Expansion of Regulatory T Cells and Facilitates Establishment of Organ Transplantation Tolerance
Hirai, T., Simonetta, F., Su, L. L., Picton, L., Baker, J., Seo, K., … Negrin, R. S. (2020). Engineered IL-2 Cytokine-Cytokine Receptor Complex Enables Selective Expansion of Regulatory T Cells and Facilitates Establishment of Organ Transplantation Tolerance. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 26(3), S59–S60. -
A novel antibody-cell conjugation method to enhance and characterize cytokine-induced killer cells.
Frank, M. J., Olsson, N., Huang, A., Tang, S.-W. W., Negrin, R. S., Elias, J. E., & Meyer, E. H. (2020). A novel antibody-cell conjugation method to enhance and characterize cytokine-induced killer cells. Cytotherapy, 22(3), 135–43. -
Autologous tumor cell vaccine induces antitumor T cell immune responses in patients with mantle cell lymphoma: A phase I/II trial.
Frank, M. J., Khodadoust, M. S., Czerwinski, D. K., Haabeth, O. A., Chu, M. P., Miklos, D. B., … Levy, R. (2020). Autologous tumor cell vaccine induces antitumor T cell immune responses in patients with mantle cell lymphoma: A phase I/II trial. The Journal of Experimental Medicine, 217(9). -
Allogeneic Chimeric Antigen Receptor-Invariant Natural Killer T Cells Exert Both Direct and Indirect Antitumor Effects through Host CD8 T Cell Cross-Priming
Simonetta, F., Hirai, T., Lohmeyer, J. K., Maas-Bauer, K., Alvarez, M., Wenokur, A. S., … Negrin, R. S. (2019). Allogeneic Chimeric Antigen Receptor-Invariant Natural Killer T Cells Exert Both Direct and Indirect Antitumor Effects through Host CD8 T Cell Cross-Priming. BLOOD, 134. -
Repertoire of Murine T Cells in Target Tissues of MHC-Matched and -Mismatched Graft-Versus-Host Disease
Zheng, P., You, X., Tamaresis, J., Xu, L., Hsu, K., Than, R., … Meyer, E. (2017). Repertoire of Murine T Cells in Target Tissues of MHC-Matched and -Mismatched Graft-Versus-Host Disease. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. ELSEVIER SCIENCE INC. -
Outcomes with autologous stem cell transplant vs. non-transplant therapy in patients 70 years and older with multiple myeloma.
Lemieux, C., Muffly, L. S., Rezvani, A., Lowsky, R., Iberri, D. J., Craig, J. K., … Sidana, S. (2020). Outcomes with autologous stem cell transplant vs. non-transplant therapy in patients 70 years and older with multiple myeloma. Bone Marrow Transplantation. -
Recipient-specific T-cell repertoire reconstitution in the gut following murine hematopoietic cell transplant.
Zheng, P., Tamaresis, J., Thangavelu, G., Xu, L., You, X., Blazar, B. R., … Meyer, E. H. (2020). Recipient-specific T-cell repertoire reconstitution in the gut following murine hematopoietic cell transplant. Blood Advances, 4(17), 4232–43. -
Visualization of activated T cells by OX40-immunoPET as a strategy for diagnosis of acute Graft-versus-Host-Disease.
Alam, I. S., Simonetta, F., Scheller, L., Mayer, A. T., Murty, S., Vermesh, O., … Gambhir, S. S. (2020). Visualization of activated T cells by OX40-immunoPET as a strategy for diagnosis of acute Graft-versus-Host-Disease. Cancer Research. -
Nonmyeloablative allogeneic transplantation achieves clinical and molecular remission in cutaneous T-cell lymphoma.
Weng, W.-K. K., Arai, S., Rezvani, A., Johnston, L., Lowsky, R., Miklos, D., … Kim, Y. H. (2020). Nonmyeloablative allogeneic transplantation achieves clinical and molecular remission in cutaneous T-cell lymphoma. Blood Advances, 4(18), 4474–82. -
Outcomes with Autologous or Allogeneic Stem Cell Transplantation in Patients with Plasma Cell Leukemia in the Era of Novel Agents.
Lemieux, C., Johnston, L. J., Lowsky, R., Muffly, L. S., Craig, J. K., Shiraz, P., … Sidana, S. (2020). Outcomes with Autologous or Allogeneic Stem Cell Transplantation in Patients with Plasma Cell Leukemia in the Era of Novel Agents. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. -
Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET.
Simonetta, F., Alam, I. S., Lohmeyer, J. K., Sahaf, B., Good, Z., Chen, W., … Negrin, R. (2020). Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET
Alam*, I. S., & Simonetta*, F. (2020). Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 1058–68. -
Infusion of Host-Derived Unlicensed NK Cells Improves Donor Engraftment in Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation.
Alvarez, M., Pierini, A., Simonetta, F., Baker, J., Maas-Bauer, K., Hirai, T., & Negrin, R. S. (2020). Infusion of Host-Derived Unlicensed NK Cells Improves Donor Engraftment in Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation. Frontiers in Immunology, 11, 614250. -
CD22-Directed CAR T-Cell Therapy Induces Complete Remissions in CD19-Directed CAR-Refractory Large B-Cell Lymphoma.
Baird, J. H., Frank, M. J., Craig, J., Patel, S., Spiegel, J. Y., Sahaf, B., … Muffly, L. (2020). CD22-Directed CAR T-Cell Therapy Induces Complete Remissions in CD19-Directed CAR-Refractory Large B-Cell Lymphoma. Blood. -
Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma
Baird, J. H., Epstein, D. J., Tamaresis, J. S., Ehlinger, Z., Spiegel, J. Y., Craig, J., … Sidana, S. (2021). Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma. BLOOD ADVANCES, 5(1), 143–55. -
Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma.
Baird, J. H., Epstein, D. J., Tamaresis, J. S., Ehlinger, Z., Spiegel, J. Y., Craig, J., … Sidana, S. (2021). Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma. Blood Advances, 5(1), 143–155. -
Use of Backup Stem Cells for Stem Cell Boost and Second Transplant in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
Liang, E. C., Muffly, L. S., Shiraz, P., Shizuru, J. A., Johnston, L., Arai, S., … Sidana, S. (2021). Use of Backup Stem Cells for Stem Cell Boost and Second Transplant in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation. Transplantation and Cellular Therapy. -
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance.
Hirai, T., Ramos, T. L., Lin, P.-Y., Simonetta, F., Su, L. L., Picton, L. K., … Negrin, R. S. (2021). Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. The Journal of Clinical Investigation, 131(8). -
Stem Cell Mobilization in Multiple Myeloma: Comparing Safety and Efficacy of Cyclophosphamide +/- Plerixafor vs. G-CSF +/- Plerixafor in the Lenalidomide Era.
Johnsrud, A., Ladha, A., Muffly, L., Shiraz, P., Goldstein, G., Osgood, V., … Sidana, S. (2021). Stem Cell Mobilization in Multiple Myeloma: Comparing Safety and Efficacy of Cyclophosphamide +/- Plerixafor vs. G-CSF +/- Plerixafor in the Lenalidomide Era. Transplantation and Cellular Therapy. -
Invariant Natural Killer T Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing and Anti-Tumor Effects.
Maas-Bauer, K., Lohmeyer, J. K., Hirai, T., Lopes Ramos, T., Fazal, F. M., Litzenburger, U. M., … Negrin, R. S. (2021). Invariant Natural Killer T Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing and Anti-Tumor Effects. Blood. -
Activation of natural killer T cells enhances the function of regulatory T-cell therapy in suppressing murine GVHD.
Hirai, T., Lin, P.-Y. Y., Simonetta, F., Maas-Bauer, K., Turkoz, M., Mavers, M., … Negrin, R. S. (2021). Activation of natural killer T cells enhances the function of regulatory T-cell therapy in suppressing murine GVHD. Blood Advances, 5(11), 2528–2538. -
Outcomes after delayed and second autologous stem cell transplant in patients with relapsed multiple myeloma.
Lemieux, C., Muffly, L. S., Iberri, D. J., Craig, J. K., Johnston, L. J., Lowsky, R., … Sidana, S. (2021). Outcomes after delayed and second autologous stem cell transplant in patients with relapsed multiple myeloma. Bone Marrow Transplantation. -
Imaging alloreactive T cells provides early warning of organ transplant rejection.
Hirai, T., Mayer, A. T., Nobashi, T. W., Lin, P.-Y., Xiao, Z., Udagawa, T., … Gambhir, S. S. (2021). Imaging alloreactive T cells provides early warning of organ transplant rejection. JCI Insight, 6(13). -
Inferior Clinical Outcomes in Recipients of Cryopreserved Grafts Following Reduced Intensity Allogeneic Hematopoietic Cell Transplantation: A Single Center Report
Bankova, A., Caveney, J., Ramos, T., Bogeholz, J., Heydari, K., Diaz, N., … Arai, S. (2021). Inferior Clinical Outcomes in Recipients of Cryopreserved Grafts Following Reduced Intensity Allogeneic Hematopoietic Cell Transplantation: A Single Center Report. BONE MARROW TRANSPLANTATION. SPRINGERNATURE. -
A fructo-oligosaccharide prebiotic is well-tolerated in adults undergoing allogeneic hematopoietic stem cell transplantation: a phase I dose-escalation trial.
Andermann, T. M., Fouladi, F., Tamburini, F. B., Sahaf, B., Tkachenko, E., Greene, C., … Bhatt, A. S. (2021). A fructo-oligosaccharide prebiotic is well-tolerated in adults undergoing allogeneic hematopoietic stem cell transplantation: a phase I dose-escalation trial. Transplantation and Cellular Therapy. -
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial.
Spiegel, J. Y., Patel, S., Muffly, L., Hossain, N. M., Oak, J., Baird, J. H., … Miklos, D. B. (2021). CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial. Nature Medicine. -
Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T Cell Cross-Priming.
Simonetta, F., Lohmeyer, J. K., Hirai, T., Maas-Bauer, K., Alvarez, M., Wenokur, A. S., … Negrin, R. (2021). Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T Cell Cross-Priming. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Concordance of peripheral blood and bone marrow measurable residual disease in adult acute lymphoblastic leukemia.
Muffly, L., Sundaram, V., Chen, C., Yurkiewicz, I., Kuo, E., Burnash, S., … Miklos, D. B. (2021). Concordance of peripheral blood and bone marrow measurable residual disease in adult acute lymphoblastic leukemia. Blood Advances, 5(16), 3147–3151. -
Development of immunosuppressive myeloid cells to induce tolerance in solid organ and hematopoietic cell transplant recipients.
Jensen, K. P., Hongo, D., Ji, X., Zheng, P., Pawar, R. D., Wu, H.-H., … Strober, S. (2021). Development of immunosuppressive myeloid cells to induce tolerance in solid organ and hematopoietic cell transplant recipients. Blood Advances. -
Incidence and Risk Factors Associated with Bleeding and Thrombosis Following Chimeric Antigen Receptor T Cell Therapy.
Johnsrud, A. J., Craig, J., Baird, J. H., Spiegel, J. Y., Muffly, L., Zehnder, J. L., … Sidana, S. (2021). Incidence and Risk Factors Associated with Bleeding and Thrombosis Following Chimeric Antigen Receptor T Cell Therapy. Blood Advances. -
Incidence and risk factors associated with bleeding and thrombosis following chimeric antigen receptor T-cell therapy
Johnsrud, A., Craig, J., Baird, J., Spiegel, J., Muffly, L., Zehnder, J., … Sidana, S. (2021). Incidence and risk factors associated with bleeding and thrombosis following chimeric antigen receptor T-cell therapy. BLOOD ADVANCES, 5(21), 4465–4475. -
Real-world Experience of Cryopreserved Allogeneic Hematopoietic Grafts in the COVID-19 Pandemic: A Single Center Report.
Bankova, A. K., Caveney, J., Yao, B., Ramos, T. L., Bogeholz, J., Heydari, K., … Arai, S. (1800). Real-world Experience of Cryopreserved Allogeneic Hematopoietic Grafts in the COVID-19 Pandemic: A Single Center Report. Transplantation and Cellular Therapy. -
Allogeneic Hematopoietic Cell Transplantation for Adult Acute Lymphoblastic Leukemia in the Modern Era.
Liang, E. C., Craig, J., Torelli, S., Cunanan, K., Iglesias, M., Arai, S., … Muffly, L. (2022). Allogeneic Hematopoietic Cell Transplantation for Adult Acute Lymphoblastic Leukemia in the Modern Era. Transplantation and Cellular Therapy. -
Multiparameter Longitudinal Imaging of Immune Cell Activity in Chimeric Antigen Receptor T Cell and Checkpoint Blockade Therapies.
Xie, J., El Rami, F., Zhou, K., Simonetta, F., Chen, Z., Zheng, X., … Rao, J. (2022). Multiparameter Longitudinal Imaging of Immune Cell Activity in Chimeric Antigen Receptor T Cell and Checkpoint Blockade Therapies. ACS Central Science, 8(5), 590–602. -
ICOS ImmunoPET Enables Visualization of Activated T Cells and Early Diagnosis of Murine Acute Gastrointestinal GvHD.
Xiao, Z., Alam, I. S., Simonetta, F., Chen, W., Scheller, L., Murty, S., … Gambhir, S. S. (2022). ICOS ImmunoPET Enables Visualization of Activated T Cells and Early Diagnosis of Murine Acute Gastrointestinal GvHD. Blood Advances. -
IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor.
Hirai, T., Lin, P.-Y., Ramos, T. L., Simonetta, F., Su, L. L., Picton, L. K., … Negrin, R. S. (2022). IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. -
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rbeta system to selectively expand regulatory T-cells in vivo.
Lopes Ramos, T., Bolivar-Wagers, S., Jin, S., Thangavelu, G., Simonetta, F., Lin, P.-Y., … Blazar, B. R. (2022). Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rbeta system to selectively expand regulatory T-cells in vivo. Blood. -
Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of GvHD.
Lohmeyer, J. K., Hirai, T., Turkoz, M., Buhler, S., Lopes Ramos, T., Kohler, N., … Simonetta, F. (2022). Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of GvHD. Blood. -
Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents.
Spinner, M. A., Sica, R. A., Tamaresis, J. S., Lu, Y., Chang, C., Lowsky, R., … Arai, S. (2023). Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents. Blood. -
Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD
Lohmeyer, J. K., Hirai, T., Turkoz, M., Buhler, S., Ramos, T. L., Koehler, N., … Simonetta, F. (2023). Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD. BLOOD, 141(14), 1755–1767. -
Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells.
Maas-Bauer, K., Köhler, N., Stell, A.-V. V., Zwick, M., Acharya, S., Rensing-Ehl, A., … Simonetta, F. (2023). Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells. Journal of Leukocyte Biology. -
Single Center Randomized Trial of T-reg graft alone versus T-reg graft Plus Tacrolimus for the Prevention of Acute GVHD.
Bader, C. S., Pavlova, A., Lowsky, R., Muffly, L., Shiraz, P., Arai, S., … Meyer, E. (2023). Single Center Randomized Trial of T-reg graft alone versus T-reg graft Plus Tacrolimus for the Prevention of Acute GVHD. Blood Advances. -
Molecular Imaging of Acute Graft-Versus-Host Disease.
Bernardi, C., Garibotto, V., Mobashwera, B., Negrin, R. S., Alam, I. S., & Simonetta, F. (2024). Molecular Imaging of Acute Graft-Versus-Host Disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. -
CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results.
Schultz, L. M., Jeyakumar, N., Kramer, A. M., Sahaf, B., Srinagesh, H., Shiraz, P., … Muffly, L. (2024). CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results. Leukemia. -
CAR19 monitoring by peripheral blood immunophenotyping reveals histology-specific expansion and toxicity.
Hamilton, M. P., Craig, E., Gentille Sanchez, C., Mina, A., Tamaresis, J., Kirmani, N., … Miklos, D. B. (2024). CAR19 monitoring by peripheral blood immunophenotyping reveals histology-specific expansion and toxicity. Blood Advances. -
Management of post-autologous transplant relapse in patients with T-cell lymphomas.
Veilleux, O., Socola, F., Arai, S., Frank, M. J., Johnston, L., Lowsky, R., … Weng, W.-K. K. (2024). Management of post-autologous transplant relapse in patients with T-cell lymphomas. American Journal of Hematology. -
Extracellular release of mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates GVHD.
Vijayan, V., Yan, H., Lohmeyer, J. K., Prentiss, K. A., Patil, R. V., Barbarito, G., … Haileselassie, B. (2024). Extracellular release of mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates GVHD. Blood Advances. -
Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma.
Bharadwaj, S., Lau, E., Hamilton, M. P., Goyal, A., Srinagesh, H., Jensen, A., … Dahiya, S. (2024). Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma. Journal for Immunotherapy of Cancer, 12(7). -
A Phase 1 Clinical Trial of NKTR-255 with CD19-22 CAR-T Cell Therapy for Refractory B-cell Acute Lymphoblastic Leukemia.
Srinagesh, H. K., Jackson, C., Shiraz, P., Jeyakumar, N., Hamilton, M. P., Egeler, E., … Muffly, L. (2024). A Phase 1 Clinical Trial of NKTR-255 with CD19-22 CAR-T Cell Therapy for Refractory B-cell Acute Lymphoblastic Leukemia. Blood. -
invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies.
Boonchalermvichian, C., Yan, H., Gupta, B., Rubin, A., Baker, J., & Negrin, R. S. (2024). invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies. Frontiers in Transplantation, 3, 1353803. -
CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study.
Frank, M. J., Baird, J. H., Kramer, A. M., Srinagesh, H. K., Patel, S., Brown, A. K., … Miklos, D. B. (2024). CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study. Lancet (London, England).
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- CIBMTR Research Database
- Safety of Myeloablative Conditioning, Orca-T, and Allogeneic, Donor-Derived CD19/CD22-CAR (Chimeric Antigen Receptor) T Cells in Adults With B-cell Acute Lymphoblastic Leukemia (ALL)
- Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel
- Cytokine Induced Killer Cells as Post-Transplant Immunotherapy Following Allogeneic Hematopoietic Cell Transplantation
- Enrichment & Purging of Stem Cells in Non-Hodgkin's Lymphoma
- Non-Myeloablative Allogeneic Transplant for Myelodysplastic Syndromes and Myeloproliferative Disorders
- Sibling and Unrelated Donor Hematopoietic Cell Transplant in Hematologic Malignancies
- TLI & ATG for Non-Myeloablative Allogeneic Transplantation for MDS and MPD
- Transplantation for Patients With Chronic Lymphocytic Leukemia
- Allo BMT in Advanced Leukemia or High Grade Lymphoma
- Targeted Therapy of Bronchiolitis Obliterans Syndrome
Practice Locations
Blood and Marrow Transplant Program (BMT) - 900 Blake Wilbur Drive Palo Alto, CA
Palo Alto, CABlood and Marrow Transplant Program (BMT) - 900 Blake Wilbur Drive
900 Blake Wilbur Drive, 2nd Floor
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
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