High-Dose Sequential Therapy and Single Autologous Transplantation for Multiple Myeloma

Trial ID or NCT#

NCT00349778

Status

not recruiting iconNOT RECRUITING

Purpose

This study uses a sequence of high-dose chemotherapy drugs and a stem cell transplant to treat multiple myeloma. The study is being performed to evaluate the efficacy and side effects of treatment. Specifically, the study is designed to reduce the risk of interstitial pneumonitis.

Official Title

High-Dose Sequential Therapy and Single Autologous Transplantation for Multiple Myeloma

Eligibility Criteria

Ages Eligible for Study: 18 to 75
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Stage II to III multiple myeloma, or progression after initial treatment of Stage I disease; early or relapsed* Age 18 to 75 years.* Pathology reviewed and the diagnosis confirmed at Stanford University Medical Center.* Patients with amyloidosis may be eligible for this trial, with approval by the Principle Investigator.* Patients must have a Karnofsky performance status \> 70%.* Aspartate aminotransferase (AST) must be \< 2 x upper limit of normal (ULN)* Alanine aminotransferase (ALT) must be \< 2 x ULN* Total bilirubin \< 2 mg/dL.* Serum creatinine \< 2.0 or 24-hour creatinine clearance ≥ 60 mL/min.* Patients must be HIV-negative.* Patients must provide signed, informed consent.
    1. EXCLUSION CRITERIA
  2. * Severe psychological or medical illness* Prior autologous hematopoietic cell transplantation* Pregnant* Lactating women* Smoldering multiple myeloma,* Monoclonal gammopathy of unknown significance or primary amyloidosis will be excluded from this study
Exclusion Criteria:
  1. * Severe psychological or medical illness* Prior autologous hematopoietic cell transplantation* Pregnant* Lactating women* Smoldering multiple myeloma,* Monoclonal gammopathy of unknown significance or primary amyloidosis will be excluded from this study
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Investigator(s)

Sally Arai
Sally Arai
Blood and marrow transplant specialist, Hematologist, Blood and marrow transplant specialist
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)

Contact us to find out if this trial is right for you.

Contact

BMT Referrals
6507230822

View on ClinicalTrials.gov