Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed Acute Myeloid Leukemia (AML)

Trial ID or NCT#

NCT00766116

Status

not recruiting iconNOT RECRUITING

Purpose

This study will test an experimental combination of the drugs Mylotarg and 5-azacitidine in the hopes of finding a treatment that may be effective against Acute Myeloid Leukemia that has come back after treatment.

Official Title

A Phase I/II Trial of the Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed AML

Eligibility Criteria

Ages Eligible for Study: 18 Years to 90 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Diagnosis of Relapsed AML* Eastern Cooperative Oncology Group (ECOG) performance status 0-2, and life expectancy \> 3 months* ≥ 18 years old* Previously untreated for current AML relapse* Adequate organ function* Written informed consent
Exclusion Criteria:
  1. * Pregnant or breast-feeding women* Growth factors that support platelet or white cell number or function must not have been administered within the past 7 days* Currently receiving another investigational drug* Currently receiving other anti-cancer agents* Uncontrolled infection* HIV positive* Received previous therapy with either Mylotarg or 5-azacitidine
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Investigator(s)

Rondeep Brar
Rondeep Brar
Hematologist-Oncologist
Clinical Associate Professor, Medicine - Hematology
Lauren Maeda
Lauren Maeda
Hematologist, Lymphoma specialist, Hematologist-Oncologist
Clinical Associate Professor, Medicine - Oncology

Contact us to find out if this trial is right for you.

Contact

Cancer Clinical Trials Office
650-498-7061

View on ClinicalTrials.gov