Personal Genomics for Preventive Cardiology
Trial ID or NCT#
NCT01406808
Status
NOT RECRUITING
Purpose
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to alter their risk.
Official Title
A Pilot Randomized Trial of Personal Genomics for Preventive Cardiology
Eligibility Criteria
Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
- - Adults age > 18 - Patient seeking cardiovascular risk evaluation - At intermediate (6-20%) or high risk (> 20%) over 10 years of CAD as defined by Framingham 10 year risk score AND/OR at > 20% risk of CAD over 30 years using the Framingham 30 year risk calculator - The genetic risk factors have been evaluated predominantly in white/European subjects. However, there is considerable overlap in the genetic architecture of South Asians and Hispanic/Latino populations. Therefore, we will limit our initial studies to these three race/ethnicity groups.
Exclusion Criteria:
- - History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or CABG - Already on lipid lowering therapy - Anticipated survival <1 year (e.g. metastatic cancer) - Serious conditions that would limit ability to adhere to recommendations (inability to take statins, exercise) - Already had genetic testing - Concurrent enrollment in another clinical trial - Pregnant or breastfeeding
Investigator(s)
Themistocles (Tim) Assimes
Michaela Kiernan
Euan A. Ashley
Cardiologist,
Heart failure cardiologist
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Carlos Bustamante
John P.A. Ioannidis
Contact us to find out if this trial is right for you.
Contact
Josh Knowles
650-804-2526
View on ClinicalTrials.gov