I am a physician-scientist and the overall theme my research has been the genetic basis of cardiovascular disease across the continuum from Discovery to the development of Model Systems to the Translation of these findings to the clinic and most recently to the Public Health aspect of genetics. I completed his MD-PhD at UNC with Prof. Nobuyo Maeda and Nobel Laureate Oliver Smithies. I did Internal Medicine residency and Cardiology fellowship training at Stanford working with Dr. Tom Quertermous. Currently my Discovery and basic translational efforts center on understanding the genetic basis of insulin resistance using GWAS studies coupled with exploration in model systems including iPSCs and CRISPR screens. My clinical translational focus is on Familial Hypercholesterolemia (FH) and I am the volunteer Chief Medical Advisor of the FH Foundation (FHF) which is a patient-led organization dedicated to increasing awareness of FH, identifying and treating patients with FH and screening family members to prevent deleterious outcomes. I helped lead the FHF efforts to establish a national patient registry (CASCADE FH), apply for an ICD10 code for FH and am now using cutting-edge “big-data” approaches to identify previously undiagnosed FH patients in electronic medical records (FIND FH). I have published over 90 papers with research projects currently funded by the National Institutes of Health, the American Diabetes Association, the American Heart Association and the Doris Duke Charitable Foundation.

Professional Summary

Professional Education
  • Fellowship: Stanford University Cardiovascular Medicine Fellowship (2010) CA
  • Residency: Stanford University Internal Medicine Residency (2005) CA
  • Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2010)
  • Medical Education: University of North Carolina - Chapel Hill (2003) NC
  • PhD, University of North Carolina, Chapel Hill, Genetics and Molecular Biology (2001)

Honors & Awards
  • Alderman Award for Excellence in Clinical Research, Stanford Cardiovascular Medicine (2008, 2009)
  • Clinical Scholar, Doris Duke Charitable Foundation (6/1/16-6/1/19)
  • Dean's Fellowship, Stanford (2005)
  • Diplomate, National Lipid Association (2012)
  • Fellow, ACC (2012)
  • Fellow, AHA (2012)
  • Fellowship Award, Future Leaders in CV Medicine (2006)
  • National Fellow to Faculty Transition Award, AHA (7/1/10-7/1/15)
  • National Innovative Research Award, AHA

Administrative Appointments
  • Chief, Translational Medicine, The FH Foundation (2012 - Present)
  • Co-Director, Translational Investigator Program (2017 - Present)
  • Co-Section Chief. Metabolism and Insulin Signaling, Stanford Diabetes Research Center` (2017 - Present)
  • Program Director, Cardiovascular Medicine Fellowship Program (2018 - Present)


Clinical Trials

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Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Practice Locations

Preventive Cardiology Stanford, CA
Stanford, CA

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 725-5909

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Hypertrophic Cardiomyopathy Center Stanford, CA
Stanford, CA

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 736-7878

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Center for Inherited Cardiovascular Disease Stanford, CA
Stanford, CA

300 Pasteur Drive, Heart Clinic 1, Clinic A21

Stanford , CA 94305

(650) 736-7878

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Patient Ratings

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Patient Reviews

(20 reviews)

Dr. Knowles is the best.
The doctors spent a lot of time with me, explanations good, I was very happy about the visit & doctors.
Dr. Schroeder recommended Dr. Knowles. I was sorry the follow up had to be postponed.
Exceeded expectations, very thorough, knowledgeable (I am a physician).
Told friends "Stanford is the best!
Very good.
Dr. Knowles spent quite a lot of time on my history and in explaining what I needed to do to improve and extend health, and motivating me to be more proactive in doing it.
Everyone was very caring & nice.
Doctor was great and took the time to go over details with me.
Very thoughtful and informed discussion of treatment options.
Good experience.
Dr. Knowles and Ms. Lamendola both are consummate professionals.
Dr. Knowles was outstanding!
Dr. Knowles is friendly, thorough, kind, professional, and shares his expertise in a clear and genuine manner.
Great doctor.
I cannot tell you how thankful I am that I am able to have such good drs. & PA's. Its a comfort.
I felt like I didn't fit his "study" protocol so he wasn't interested in me anymore.
He was very informative.
My doc didn't give info on my meds b/c he didn't prescribe them.
He was amazing!

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