rTMS for Orthopaedic Trauma Patients

Trial ID or NCT#



not recruiting iconNOT RECRUITING


This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for orthopaedic trauma patients. In this open label study, all participants will receive accelerated theta-burst stimulation. This study will examine whether symptoms of psychiatric distress and opioid use in orthopaedic trauma patients can be mitigated with rTMS to improve post-injury recovery.

Official Title

Repetitive Transcranial Magnetic Stimulation (rTMS) for Orthopaedic Trauma Patients

Eligibility Criteria

Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Male or female, 18 to 65 years of age. - Able to provide informed consent. - Present to Stanford Emergency Department as a trauma with a major operative lower extremity injury - Glasgow coma scale of 15 within 24 hours after admission or extubation - Negative urinary toxicology screen for illicit substances; - Negative pregnancy test if female and less then 60 y/o; - No suspicion for a head injury and/or negative head CT scan for intracranial hemorrhage or injury based on standard of care - No history of seizure disorder or other neurological disorders. - All patients included must screen positive for PHQ-9 score >4 (positive symptoms of depression) and CES-T score <36 (poor coping self-efficacy).
Exclusion Criteria:
  1. - Incarceration, - Pregnant females, - Prior psychotic disorder, - Current use of anti-depressant or anti-psychotic medications, - Prior-admission opioid use within 30 days (patients will be screened for recent prescription opioid use using the CURES report), - Heavy alcohol use, - Lesional neurological disorder or brain implant or intracranial ferromagnetic material, - Seizure disorder


Nolan Williams
Nolan Williams
Deep brain stimulation specialist, Neuroimaging specialist, Psychiatrist
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)

Contact us to find out if this trial is right for you.


Romina Nejad, MSc