Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance
Trial ID or NCT#
The primary objective of this study is to determine whether treatment with armodafinil will provide improvements in prefrontal cortical activation in patients with OSAHS (Obstructive Sleep Apnea/Hypopnea Syndrome) who have residual sleepiness despite receiving nCPAP therapy.
Double-Blind, Placebo-Controlled, Functional Neuroimaging Study of Armodafinil (200 mg/Day) on Prefrontal Cortical Activation in Patients With Residual Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea
- - Patient has a current diagnosis of OSAHS and has a complaint of excessive sleepiness despite effective nCPAP therapy.
- - Patient has excessive sleepiness as evidenced by a mean sleep latency of less than 8 minutes, as determined by the MSLT.
- - Patient has an ESS score of 10 or more at the initial screening visit.
- - Patient has a habitual sleep time beginning no earlier than 2100 and ending no later than 0700.
- - Patient is right-handed. Patients who are ambidextrous may be eligible following consultation with the medical monitor.
- - Women of childbearing potential must use a medically accepted method of contraception and must agree to continue use of this method for the duration of the study and for 30 days after participation in the study.
- - Patient exhibits reasonable accuracy (≥80%) on the 2-back working memory task during the training session at the second screening visit.
- The Patient:
- - The patient is a current smoker or has a prior history of smoking (defined as ≥1 pack-year) within 2 years prior to the screening visit.
- - consumes caffeine including coffee, tea and/or other caffeine-containing beverages or food averaging more than 400 mg of caffeine per day (approximately equivalent to 4 or more cups of coffee).
- - has NART-predicted verbal IQ and QIDS-SR16 scores within protocol-specific exclusionary ranges.
- - has a clinically significant, uncontrolled medical or psychiatric conditions (treated or untreated).
- - has a confirmed or probable diagnosis of a current sleep disorder other than OSAHS.
- - has used any excluded prescription drugs or procedures for prohibited and allowed drugs within the excluded timeframe.
- - has a history of alcohol, narcotic, or any other drug abuse.
- - has a positive UDS, without medical explanation, at the screening visit.
- - has a clinically significant deviation from normal in the physical examination.
- - is a pregnant or lactating woman. Any woman becoming pregnant during the study will be withdrawn from the study.
- - has a past or present seizure disorder, head trauma that is clinically significant, or past neurosurgery.
- - has used an investigational drug within 1 month before the screening visit.
- - has any disorder that may interfere with drug absorption, distribution, metabolism, or excretion (including gastrointestinal surgery).
- - has a known hypersensitivity to armodafinil or modafinil, or any other component of the study drug tablets.
- - has a history of any clinically significant cutaneous drug reaction, or a history of clinically significant hypersensitivity reaction, including multiple allergies or drug reactions.
- - has known human immunodeficiency virus (HIV).
- - has clinical laboratory test value(s) outside the range(s) specified in the Protocol, or presents a clinically significant laboratory abnormality without prior written approval by the medical monitor.
- - has worked the night shift within 28 days of the baseline visit, or will work the night shift during the double-blind segment of the study.
- - anticipates any travel across more than 3 time zones at any time during the study.
- - needs to use any of the excluded medications identified in this protocol.
- - is unable to complete neuroimaging studies, performance tasks, self-rating scales, and all other study assessments.
- - has a contraindication to fMRI scanning, (such as an implanted pacemaker/defibrillator, aneurysm clips, drug infusion device or metallic foreign body).
- - is suspected to be unable to tolerate fMRI scanning (eg, claustrophobic) and/or the testing paradigm.
- - has physical or other characteristics that suggest imaging data will be unobtainable or degraded.
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