Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Trial ID or NCT#

NCT02312882

Status

not recruiting iconNOT RECRUITING

Purpose

The purpose of this study is to investigate the ability of tofacitinib citrate, a Janus kinase inhibitor, to generate hair regrowth in patients with moderate to severe alopecia areata and its variants.

Official Title

Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Age \>= 18 years old* Diagnosis of alopecia areata with \>50% scalp involvement, alopecia totalis, or alopecia universalis* Hair loss present for at least 6 months* No treatment for alopecia areata in past 2 months* No evidence of hair regrowth* Females of childbearing potential must use birth control while taking the medication and there must be a negative pregnancy test documented prior to starting the medication* Fluent in spoken and written English
Exclusion Criteria:
  1. * Age \<18 years old* Patients have received treatment known to affect alopecia areata within 2 months of enrolling in the study* Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin)* Patients known to be HIV or hepatitis B or C positive* Patients with positive tuberculin skin test or positive QuantiFERON TB test* Patients with leukopenia or anemia* Patients with renal or hepatic impairment* Patients with peptic ulcer disease* Patients taking immunosuppressive medications, including but not limited to prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or TNH-alpha inhibitors* Women of childbearing potential who are unable or unwilling to use birth control while taking the medication* Women who are pregnant or nursing
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Investigator(s)

Anthony Oro, MD, PhD
Anthony Oro, MD, PhD
Dermatologist, Hair loss specialist, Dermatologic oncologist, Cutaneous oncology specialist, Skin stem cell specialist
Eugene and Gloria Bauer Professor
Justin M Ko, MD, MBA
Justin M Ko, MD, MBA
Dermatologist, Melanoma specialist, Cutaneous oncology specialist, Hair loss specialist, Psoriasis specialist
Clinical Professor, Dermatology

Contact us to find out if this trial is right for you.

Contact

Michelle Kim

View on ClinicalTrials.gov