Publications

• Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma.
  Jaju, P. D., Nguyen, C. B., Mah, A. M., Atwood, S. X., Li, J., & Sarin, K. Y. (2015). Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. journal of investigative dermatology, 135(12), 3197-3200.
• RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors
  Zhao, X., Ponomaryov, T., Ornell, K. J., Zhou, P., Dabral, S. K., & Segal, R. A. (2015). RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. CANCER RESEARCH, 75(17), 3623-3635.
• Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
  Atwood, S. X., Sarin, K. Y., Whitson, R. J., Li, J. R., Kim, G., & Tang, J. Y. (2015). Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma. CANCER CELL, 27(3), 342-353.
• Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa Sebastiano, V., Zhen, H. H., Derafshi, B. H., Bashkirova, E., Melo, S. P., & Oro, A. E. (2014). Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. SCIENCE TRANSLATIONAL MEDICINE, 6(264).
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., & Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. NATURE MEDICINE, 20(7), 732-740.
  
• Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant Melo, S. P., Lisowski, L., Bashkirova, E., Zhen, H. H., Chu, K., & Oro, A. E. (2014). Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. MOLECULAR THERAPY, 22(4), 725-733.
  
• "Atypical" regulation of Hedgehog-dependent cancers. Atwood, S. X., & Oro, A. E. (2014). "Atypical" regulation of Hedgehog-dependent cancers. Cancer cell, 25(2), 133-134.
  
• Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., & Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin. STEM CELLS, 32(1), 85-92.
  
• State-dependent signaling by Ca(v)1.2 regulates hair follicle stem cell function Yucel, G., Altindag, B., Gomez-Ospina, N., Rana, A., Panagiotakos, G., & Oro, A. E. (2013). State-dependent signaling by Ca(v)1.2 regulates hair follicle stem cell function. GENES & DEVELOPMENT, 27(11), 1217-1222.
  
• GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. NATURE, 494(7438), 484-488.
  
• Hedgehog pathway inhibition and the race against tumor evolution Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2013). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 45-49.
  
• Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Journal of visualized experiments : JoVE, (72).
  
• Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma Sekulic, A., Migden, M. R., Oro, A. E., Dirix, L., Lewis, K. D., & Hauschild, A. (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2171-2179.
  
• Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma Gomez-Ospina, N., Chang, A. L. S., Qu, K., & Oro, A. E. (2012). Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2233-2234.
  
• Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop Woo, W.-M., Zhen, H. H., & Oro, A. E. (2012). Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. GENES & DEVELOPMENT, 26(11), 1235-1246.
  
• Neuropilins are positive regulators of Hedgehog signal transduction Hillman, R. T., Feng, B. Y., Ni, J., Woo, W.-M., Milenkovic, L., & Scott, M. P. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. GENES & DEVELOPMENT, 25(22), 2333-2346.
  
• SnapShot: Hair Follicle Stem Cells Woo, W.-M., & Oro, A. E. (2011). SnapShot: Hair Follicle Stem Cells. CELL, 146(2), 334-U159.
  
• Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip Yucel, G., & Oro, A. E. (2011). Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip. CELL, 144(3), 319-321.
  
• MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling Bershteyn, M., Atwood, S. X., Woo, W.-M., Li, M., & Oro, A. E. (2010). MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling. DEVELOPMENTAL CELL, 19(2), 270-283.
  
• I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration Quinones, G. A., Jin, J., & Oro, A. E. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. JOURNAL OF CELL BIOLOGY, 189(2), 353-367.
  
• Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. Atwood, S. X., Sarin, K. Y., Li, J. R., Yao, C. Y., Urman, N. M., & Oro, A. E. (2015). Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. journal of investigative dermatology, 135(8), 2138-2141.
  
• An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Ally, M. S., Aasi, S., Wysong, A., Teng, C., Anderson, E., & Tang, J. Y. (2014). An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Journal of the American Academy of Dermatology, 71(5), 904-911 e1.
  
• Advanced treatment for basal cell carcinomas. Atwood, S. X., Whitson, R. J., & Oro, A. E. (2014). Advanced treatment for basal cell carcinomas. Cold Spring Harbor perspectives in medicine, 4(7).
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., & Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature medicine, 20(7), 732-740.
  
• Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., & Helms, J. A. (2013). Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing. PLOS ONE, 8(10).
  
• Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72).
  
• Hedgehog pathway inhibition and the race against tumor evolution Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2012). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 199(2), 193-197.
  
• A perivascular stem cell niche in the hair follicle Xiao, Y., Woo, W., Terunuma, A., Oro, A. E., Vogel, J. C., & Brownell, I. (2012). A perivascular stem cell niche in the hair follicle. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, S79-S79.
  
• In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope Ra, H., Piyawattanametha, W., Gonzalez-Gonzalez, E., Mandella, M. J., Kino, G. S., & Contag, C. H. (2011). In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(5), 1061-1066.
  
• Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation DeRouen, M. C., Zhen, H., Tan, S. H., Williams, S., Marinkovich, M. P., & Oro, A. E. (2010). Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC DEVELOPMENTAL BIOLOGY, 10.
  
• BAR domain competition during directional cellular migration Quinones, G. A., & Oro, A. E. (2010). BAR domain competition during directional cellular migration. CELL CYCLE, 9(13), 2522-2528.
  
• The Primary Cilium: A Small Yet Mighty Organelle DeRouen, M. C., & Oro, A. E. (2009). The Primary Cilium: A Small Yet Mighty Organelle. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129(2), 264-265.
  
• Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis Gao, J., DeRouen, M. C., Chen, C.-H., Nguyen, M., Nguyen, N. T., & Marinkovich, M. P. (2008). Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. GENES & DEVELOPMENT, 22(15), 2111-2124.
  
• Controlling hair follicle signaling pathways through polyubiquitination Huntzicker, E. G., & Oro, A. E. (2008). Controlling hair follicle signaling pathways through polyubiquitination. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(5), 1081-1087.
  
• A new role for an old friend: NFAT and stem cell quiescence Oro, A. E. (2008). A new role for an old friend: NFAT and stem cell quiescence. CELL STEM CELL, 2(2), 104-106.
  
• Role of the basement membrane zone in skin development. Oro, A. E. (2008). Role of the basement membrane zone in skin development. journal of investigative dermatology, 128(E2), E11-2.
  
• The primary cilia, a 'Rab-id' transit system for hedgehog signaling Oro, A. E. (2007). The primary cilia, a 'Rab-id' transit system for hedgehog signaling. CURRENT OPINION IN CELL BIOLOGY, 19(6), 691-696.
  
• Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., & Brown, P. O. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14842-14847.
  
• Dual degradation signals control Gli protein stability and tumor formation Huntzicker, E. G., Estay, I. S., Zhen, H., Lokteva, L. A., Jackson, P. K., & Oro, A. E. (2006). Dual degradation signals control Gli protein stability and tumor formation. GENES & DEVELOPMENT, 20(3), 276-281.
  
• Mammalian variations on a theme: a Smo and Sufu surprise Oro, A. E. (2006). Mammalian variations on a theme: a Smo and Sufu surprise. DEVELOPMENTAL CELL, 10(2), 156-158.
  
• Conditional telomerase induction causes proliferation of hair follicle stem cells Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., & Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. NATURE, 436(7053), 1048-1052.
  
• Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF CELL BIOLOGY, 168(3), 453-463.
  
• MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription Callahan, C. A., Ofstad, T., Horng, L., Wang, J. K., Zhen, H. H., & Oro, A. E. (2004). MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. GENES & DEVELOPMENT, 18(22), 2724-2729.
  
• Laminin-10 is crucial for hair morphogenesis Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., & Marinkovich, M. P. (2003). Laminin-10 is crucial for hair morphogenesis. EMBO JOURNAL, 22(10), 2400-2410.
  
• Hair cycle regulation of Hedgehog signal reception Oro, A. E., & Higgins, K. (2003). Hair cycle regulation of Hedgehog signal reception. DEVELOPMENTAL BIOLOGY, 255(2), 238-248.
  
• Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., & Epstein, E. H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. NATURE MEDICINE, 5(11), 1285-1291.
  
• Hedgehog/patched signaling in animal development and disease Scott, M. P., Goodrich, L. V., Higgins, K. M., Johnson, R. L., Milenkovic, L., & Oro, A. E. (1997). Hedgehog/patched signaling in animal development and disease. FASEB JOURNAL, 11(9), A1302-A1302.
  
• Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. Fan, H., Oro, A. E., Scott, M. P., & Khavari, P. A. (1997). Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108(4), 38-38.
  
• MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE Oro, A. E., Newton, K. J., & Walbot, V. (1985). MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE. THEORETICAL AND APPLIED GENETICS, 70(3), 287-293.