Publications

• Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
  Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., Scott, M. P., & Epstein, E. H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. NATURE MEDICINE, 5(11), 1285–1291.
• Hair cycle regulation of Hedgehog signal reception
  Oro, A. E., & Higgins, K. (2003). Hair cycle regulation of Hedgehog signal reception. DEVELOPMENTAL BIOLOGY, 255(2), 238–248.
• Laminin-10 is crucial for hair morphogenesis
  Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., Gao, J., … Marinkovich, M. P. (2003). Laminin-10 is crucial for hair morphogenesis. EMBO JOURNAL, 22(10), 2400–2410.
• MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription Callahan, C. A., Ofstad, T., Horng, L., Wang, J. K., Zhen, H. H., Coulombe, P. A., & Oro, A. E. (2004). MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. GENES & DEVELOPMENT, 18(22), 2724–2729.
  
• Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF CELL BIOLOGY, 168(3), 453–463.
  
• Conditional telomerase induction causes proliferation of hair follicle stem cells Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., … Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. NATURE, 436(7053), 1048–1052.
  
• Dual degradation signals control Gli protein stability and tumor formation Huntzicker, E. G., Estay, I. S., Zhen, H., Lokteva, L. A., Jackson, P. K., & Oro, A. E. (2006). Dual degradation signals control Gli protein stability and tumor formation. GENES & DEVELOPMENT, 20(3), 276–281.
  
• Mammalian variations on a theme: a Smo and Sufu surprise Oro, A. E. (2006). Mammalian variations on a theme: a Smo and Sufu surprise. DEVELOPMENTAL CELL, 10(2), 156–158.
  
• Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., West, R., … Brown, P. O. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14842–14847.
  
• The primary cilia, a 'Rab-id' transit system for hedgehog signaling Oro, A. E. (2007). The primary cilia, a 'Rab-id' transit system for hedgehog signaling. CURRENT OPINION IN CELL BIOLOGY, 19(6), 691–696.
  
• A new role for an old friend: NFAT and stem cell quiescence Oro, A. E. (2008). A new role for an old friend: NFAT and stem cell quiescence. CELL STEM CELL, 2(2), 104–106.
  
• Controlling hair follicle signaling pathways through polyubiquitination Huntzicker, E. G., & Oro, A. E. (2008). Controlling hair follicle signaling pathways through polyubiquitination. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(5), 1081–1087.
  
• Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis Gao, J., DeRouen, M. C., Chen, C.-H., Nguyen, M., Nguyen, N. T., Ido, H., … Marinkovich, M. P. (2008). Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. GENES & DEVELOPMENT, 22(15), 2111–2124.
  
• The Primary Cilium: A Small Yet Mighty Organelle DeRouen, M. C., & Oro, A. E. (2009). The Primary Cilium: A Small Yet Mighty Organelle. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129(2), 264–265.
  
• I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration Quinones, G. A., Jin, J., & Oro, A. E. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. JOURNAL OF CELL BIOLOGY, 189(2), 353–367.
  
• BAR domain competition during directional cellular migration Quinones, G. A., & Oro, A. E. (2010). BAR domain competition during directional cellular migration. CELL CYCLE, 9(13), 2522–2528.
  
• MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling Bershteyn, M., Atwood, S. X., Woo, W.-M., Li, M., & Oro, A. E. (2010). MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling. DEVELOPMENTAL CELL, 19(2), 270–283.
  
• Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation DeRouen, M. C., Zhen, H., Tan, S. H., Williams, S., Marinkovich, M. P., & Oro, A. E. (2010). Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC DEVELOPMENTAL BIOLOGY, 10.
  
• In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope Ra, H., Piyawattanametha, W., Gonzalez-Gonzalez, E., Mandella, M. J., Kino, G. S., Solgaard, O., … Contag, C. H. (2011). In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(5), 1061–1066.
  
• Role of the basement membrane zone in skin development. Oro, A. E. (2008). Role of the basement membrane zone in skin development. Journal of Investigative Dermatology, 128(E2), E11–2.
  
• Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip Yucel, G., & Oro, A. E. (2011). Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip. CELL, 144(3), 319–321.
  
• SnapShot: Hair Follicle Stem Cells Woo, W.-M., & Oro, A. E. (2011). SnapShot: Hair Follicle Stem Cells. CELL, 146(2), 334–U159.
  
• Neuropilins are positive regulators of Hedgehog signal transduction Hillman, R. T., Feng, B. Y., Ni, J., Woo, W.-M., Milenkovic, L., Gephart, M. G. H., … Scott, M. P. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. GENES & DEVELOPMENT, 25(22), 2333–2346.
  
• Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop Woo, W.-M., Zhen, H. H., & Oro, A. E. (2012). Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. GENES & DEVELOPMENT, 26(11), 1235–1246.
  
• Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma Sekulic, A., Migden, M. R., Oro, A. E., Dirix, L., Lewis, K. D., Hainsworth, J. D., … Hauschild, A. (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2171–2179.
  
• Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma Gomez-Ospina, N., Chang, A. L. S., Qu, K., & Oro, A. E. (2012). Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2233–2234.
  
• Hedgehog pathway inhibition and the race against tumor evolution Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2012). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 199(2), 193–197.
  
• GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature, 494(7438), 484–488.
  
• Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Journal of Visualized Experiments : JoVE, (72).
  
• State-dependent signaling by Cav1.2 regulates hair follicle stem cell function. Yucel, G., Altindag, B., Gomez-Ospina, N., Rana, A., Panagiotakos, G., Lara, M. F., … Oro, A. E. (2013). State-dependent signaling by Cav1.2 regulates hair follicle stem cell function. Genes & Development, 27(11), 1217–1222.
  
• Hedgehog/patched signaling in animal development and disease Scott, M. P., Goodrich, L. V., Higgins, K. M., Johnson, R. L., Milenkovic, L., & Oro, A. E. (1997). Hedgehog/patched signaling in animal development and disease. FASEB JOURNAL, 11(9), A1302–A1302.
  
• Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. Fan, H., Oro, A. E., Scott, M. P., & Khavari, P. A. (1997). Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108(4), 38–38.
  
• Hedgehog pathway inhibition and the race against tumor evolution Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2013). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 45–49.
  
• A perivascular stem cell niche in the hair follicle Xiao, Y., Woo, W., Terunuma, A., Oro, A. E., Vogel, J. C., & Brownell, I. (2012). A perivascular stem cell niche in the hair follicle. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC: NATURE PUBLISHING GROUP.
  
• Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124(4), A103–A103.
  
• MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE Oro, A. E., Newton, K. J., & Walbot, V. (1985). MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE. THEORETICAL AND APPLIED GENETICS, 70(3), 287–293.
  
• Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., Dhamdhere, G. R., … Helms, J. A. (2013). Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing. PLOS ONE, 8(10).
  
• Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin. Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., Lara, M. F., … Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin. Stem Cells , 32(1), 85–92.
  
• "Atypical" regulation of Hedgehog-dependent cancers. Atwood, S. X., & Oro, A. E. (2014). "Atypical" regulation of Hedgehog-dependent cancers. Cancer Cell, 25(2), 133–134.
  
• Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. Melo, S. P., Lisowski, L., Bashkirova, E., Zhen, H. H., Chu, K., Keene, D. R., … Oro, A. E. (2014). Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. Molecular Therapy : the Journal of the American Society of Gene Therapy, 22(4), 725–733.
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature Medicine, 20(7), 732–740.
  
• Advanced treatment for basal cell carcinomas. Atwood, S. X., Whitson, R. J., & Oro, A. E. (2014). Advanced treatment for basal cell carcinomas. Cold Spring Harbor Perspectives in Medicine, 4(7).
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. NATURE MEDICINE, 20(7), 732–740.
  
• Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa Sebastiano, V., Zhen, H. H., Derafshi, B. H., Bashkirova, E., Melo, S. P., Wang, P., … Oro, A. E. (2014). Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. SCIENCE TRANSLATIONAL MEDICINE, 6(264).
  
• Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72).
  
• Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Atwood, S. X., Sarin, K. Y., Whitson, R. J., Li, J. R., Kim, G., Rezaee, M., … Tang, J. Y. (2015). Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Cancer Cell, 27(3), 342–53.
  
• Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. Atwood, S. X., Sarin, K. Y., Li, J. R., Yao, C. Y., Urman, N. M., Chang, A. L. S., … Oro, A. E. (2015). Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. Journal of Investigative Dermatology, 135(8), 2138–2141.
  
• An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Ally, M. S., Aasi, S., Wysong, A., Teng, C., Anderson, E., Bailey-Healy, I., … Tang, J. Y. (2014). An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Journal of the American Academy of Dermatology, 71(5), 904–911 e1.
  
• Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. Jaju, P. D., Nguyen, C. B., Mah, A. M., Atwood, S. X., Li, J., Zia, A., … Sarin, K. Y. (2015). Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. Journal of Investigative Dermatology, 135(12), 3197–3200.
  
• RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Zhao, X., Ponomaryov, T., Ornell, K. J., Zhou, P., Dabral, S. K., Pak, E., … Segal, R. A. (2015). RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Research, 75(17), 3623–3635.
  
• Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. Ally, M. S., Ransohoff, K., Sarin, K., Atwood, S. X., Rezaee, M., Bailey-Healy, I., … Colevas, A. D. (2016). Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. JAMA Dermatology, 152(4), 452–456.
  
• An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib Danial, C., Sarin, K. Y., Oro, A. E., & Chang, A. L. S. (2016). An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib. CLINICAL CANCER RESEARCH, 22(6), 1325–1329.
  
• Role of the Basement Membrane Zone in Skin Development. Oro, A. E. (2008). Role of the Basement Membrane Zone in Skin Development. Journal of Investigative Dermatology, 128, E11–2.
  
• Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth. Smith, A. A., Li, J., Liu, B., Hunter, D., Pyles, M., Gillette, M., … Helms, J. A. (2016). Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth. Journal of Investigative Dermatology, 136(8), 1549–58.
  
• GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. NATURE, 494(7438), 484–488.
  
• Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. Kennedy Crispin, M., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1(15).
  
• Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior. Whitson, R. J., & Oro, A. E. (2017). Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior. Cell Stem Cell, 20(2), 149–150.
  
• Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions Urman, N. M., Mirza, A., Atwood, S. X., Whitson, R. J., Sarin, K. Y., Tang, J. Y., & Oro, A. E. (2016). Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. PLOS ONE, 11(12).