Biography
Professional Summary
Education & Certifications
- Medical Education: University of California San Diego School of Medicine (1993) CA
- Residency: Stanford University Dermatology Residency (1997) CA
- Internship: Stanford University Internal Medicine Residency (1994) CA
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- Board Certification: American Board of Dermatology, Dermatology (1998)
Administrative Appointments
- Assoc Director, Center for Definitive and Curative Medicine (2016 - Present)
- Co-Director, Child Health Research Institute (2017 - Present)
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Publications
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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., Scott, M. P., & Epstein, E. H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. NATURE MEDICINE, 5(11), 1285–1291. -
Hair cycle regulation of Hedgehog signal reception
Oro, A. E., & Higgins, K. (2003). Hair cycle regulation of Hedgehog signal reception. DEVELOPMENTAL BIOLOGY, 255(2), 238–48. -
Laminin-10 is crucial for hair morphogenesis
Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., Gao, J., … Marinkovich, M. P. (2003). Laminin-10 is crucial for hair morphogenesis. EMBO JOURNAL, 22(10), 2400–2410. -
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MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
Callahan, C. A., Ofstad, T., Horng, L., Wang, J. K., Zhen, H. H., Coulombe, P. A., & Oro, A. E. (2004). MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. GENES & DEVELOPMENT, 18(22), 2724–29. -
Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF CELL BIOLOGY, 168(3), 453–63. -
Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., … Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. NATURE, 436(7053), 1048–52. -
Dual degradation signals control Gli protein stability and tumor formation
Huntzicker, E. G., Estay, I. S., Zhen, H., Lokteva, L. A., Jackson, P. K., & Oro, A. E. (2006). Dual degradation signals control Gli protein stability and tumor formation. GENES & DEVELOPMENT, 20(3), 276–81. -
Mammalian variations on a theme: a Smo and Sufu surprise
Oro, A. E. (2006). Mammalian variations on a theme: a Smo and Sufu surprise. DEVELOPMENTAL CELL, 10(2), 156–58. -
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., West, R., … Brown, P. O. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14842–47. -
The primary cilia, a 'Rab-id' transit system for hedgehog signaling
Oro, A. E. (2007). The primary cilia, a 'Rab-id' transit system for hedgehog signaling. CURRENT OPINION IN CELL BIOLOGY, 19(6), 691–96. -
A new role for an old friend: NFAT and stem cell quiescence
Oro, A. E. (2008). A new role for an old friend: NFAT and stem cell quiescence. CELL STEM CELL, 2(2), 104–6. -
Controlling hair follicle signaling pathways through polyubiquitination
Huntzicker, E. G., & Oro, A. E. (2008). Controlling hair follicle signaling pathways through polyubiquitination. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(5), 1081–87. -
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
Gao, J., DeRouen, M. C., Chen, C.-H., Nguyen, M., Nguyen, N. T., Ido, H., … Marinkovich, M. P. (2008). Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. GENES & DEVELOPMENT, 22(15), 2111–24. -
The Primary Cilium: A Small Yet Mighty Organelle
DeRouen, M. C., & Oro, A. E. (2009). The Primary Cilium: A Small Yet Mighty Organelle. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129(2), 264–65. -
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration
Quinones, G. A., Jin, J., & Oro, A. E. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. JOURNAL OF CELL BIOLOGY, 189(2), 353–67. -
BAR domain competition during directional cellular migration
Quinones, G. A., & Oro, A. E. (2010). BAR domain competition during directional cellular migration. CELL CYCLE, 9(13), 2522–28. -
MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling
Bershteyn, M., Atwood, S. X., Woo, W.-M., Li, M., & Oro, A. E. (2010). MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling. DEVELOPMENTAL CELL, 19(2), 270–83. -
Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation
DeRouen, M. C., Zhen, H., Tan, S. H., Williams, S., Marinkovich, M. P., & Oro, A. E. (2010). Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC DEVELOPMENTAL BIOLOGY, 10. -
In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope
Ra, H., Piyawattanametha, W., Gonzalez-Gonzalez, E., Mandella, M. J., Kino, G. S., Solgaard, O., … Contag, C. H. (2011). In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(5), 1061–66. -
Role of the basement membrane zone in skin development.
Oro, A. E. (2008). Role of the basement membrane zone in skin development. Journal of Investigative Dermatology, 128(E2), E11–2. -
Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip
Yucel, G., & Oro, A. E. (2011). Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip. CELL, 144(3), 319–21. -
SnapShot: Hair Follicle Stem Cells
Woo, W.-M., & Oro, A. E. (2011). SnapShot: Hair Follicle Stem Cells. CELL, 146(2), 334–U159. -
Neuropilins are positive regulators of Hedgehog signal transduction
Hillman, R. T., Feng, B. Y., Ni, J., Woo, W.-M., Milenkovic, L., Gephart, M. G. H., … Scott, M. P. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. GENES & DEVELOPMENT, 25(22), 2333–46. -
Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
Woo, W.-M., Zhen, H. H., & Oro, A. E. (2012). Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. GENES & DEVELOPMENT, 26(11), 1235–46. -
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Sekulic, A., Migden, M. R., Oro, A. E., Dirix, L., Lewis, K. D., Hainsworth, J. D., … Hauschild, A. (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2171–2179. -
Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma
Gomez-Ospina, N., Chang, A. L. S., Qu, K., & Oro, A. E. (2012). Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2233–2234. -
Hedgehog pathway inhibition and the race against tumor evolution
Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2012). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 199(2), 193–97. -
GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas.
Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature, 494(7438), 484–88. -
Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration.
Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Journal of Visualized Experiments : JoVE, (72). -
State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.
Yucel, G., Altindag, B., Gomez-Ospina, N., Rana, A., Panagiotakos, G., Lara, M. F., … Oro, A. E. (2013). State-dependent signaling by Cav1.2 regulates hair follicle stem cell function. Genes & Development, 27(11), 1217–22. -
Hedgehog/patched signaling in animal development and disease
Scott, M. P., Goodrich, L. V., Higgins, K. M., Johnson, R. L., Milenkovic, L., & Oro, A. E. (1997). Hedgehog/patched signaling in animal development and disease. FASEB JOURNAL, 11(9), A1302–A1302. -
Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo.
Fan, H., Oro, A. E., Scott, M. P., & Khavari, P. A. (1997). Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108(4), 38–38. -
Hedgehog pathway inhibition and the race against tumor evolution
Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2013). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 45–49. -
A perivascular stem cell niche in the hair follicle
Xiao, Y., Woo, W., Terunuma, A., Oro, A. E., Vogel, J. C., & Brownell, I. (2012). A perivascular stem cell niche in the hair follicle. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC: NATURE PUBLISHING GROUP. -
Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124(4), A103–A103. -
MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE
Oro, A. E., Newton, K. J., & Walbot, V. (1985). MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE. THEORETICAL AND APPLIED GENETICS, 70(3), 287–293. -
Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing
Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., Dhamdhere, G. R., … Helms, J. A. (2013). Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing. PLOS ONE, 8(10). -
Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin.
Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., Lara, M. F., … Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin. Stem Cells , 32(1), 85–92. -
"Atypical" regulation of Hedgehog-dependent cancers.
Atwood, S. X., & Oro, A. E. (2014). "Atypical" regulation of Hedgehog-dependent cancers. Cancer Cell, 25(2), 133–34. -
Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant.
Melo, S. P., Lisowski, L., Bashkirova, E., Zhen, H. H., Chu, K., Keene, D. R., … Oro, A. E. (2014). Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. Molecular Therapy : the Journal of the American Society of Gene Therapy, 22(4), 725–33. -
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature Medicine, 20(7), 732–40. -
Advanced treatment for basal cell carcinomas.
Atwood, S. X., Whitson, R. J., & Oro, A. E. (2014). Advanced treatment for basal cell carcinomas. Cold Spring Harbor Perspectives in Medicine, 4(7). -
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. NATURE MEDICINE, 20(7), 732–40. -
Epigenetic targeting of hedgehog pathway transcriptional output.
Cho, Y.-J. J., Tang, Y., Schubert, S., Willardson, M., Bandopadhayay, P., Bergthold, G., … Cho, Y.-J. J. (2014). Epigenetic targeting of hedgehog pathway transcriptional output. Neuro-Oncology, 16 Suppl 3, iii25. -
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa
Sebastiano, V., Zhen, H. H., Derafshi, B. H., Bashkirova, E., Melo, S. P., Wang, P., … Oro, A. E. (2014). Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. SCIENCE TRANSLATIONAL MEDICINE, 6(264). -
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72). -
Smoothened variants explain the majority of drug resistance in Basal cell carcinoma.
Atwood, S. X., Sarin, K. Y., Whitson, R. J., Li, J. R., Kim, G., Rezaee, M., … Tang, J. Y. (2015). Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Cancer Cell, 27(3), 342–53. -
Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.
Atwood, S. X., Sarin, K. Y., Li, J. R., Yao, C. Y., Urman, N. M., Chang, A. L. S., … Oro, A. E. (2015). Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. Journal of Investigative Dermatology, 135(8), 2138–41. -
An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma.
Ally, M. S., Aasi, S., Wysong, A., Teng, C., Anderson, E., Bailey-Healy, I., … Tang, J. Y. (2014). An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Journal of the American Academy of Dermatology, 71(5), 904–11 e1. -
Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma.
Ally, M. S., Ransohoff, K., Sarin, K., Atwood, S. X., Rezaee, M., Bailey-Healy, I., … Colevas, A. D. (2016). Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. JAMA Dermatology, 152(4), 452–56. -
Effects of combined treatment with arsenic trioxide and itraconazole in patients with refractory metastatic basal cell carcinoma
Sarin, K. Y., Ally, M. S., Ransohoff, K. J., Atwood, S. X., & Rezaee, M. (2016). Effects of combined treatment with arsenic trioxide and itraconazole in patients with refractory metastatic basal cell carcinoma. JAMA Dermatology, 1–5. -
An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib
Danial, C., Sarin, K. Y., Oro, A. E., & Chang, A. L. S. (2016). An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib. CLINICAL CANCER RESEARCH, 22(6), 1325–29. -
Role of the Basement Membrane Zone in Skin Development.
Oro, A. E. (2008). Role of the Basement Membrane Zone in Skin Development. Journal of Investigative Dermatology, 128, E11–2. -
GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. NATURE, 494(7438), 484–88. -
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.
Kennedy Crispin, M., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1(15). -
Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior.
Whitson, R. J., & Oro, A. E. (2017). Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior. Cell Stem Cell, 20(2), 149–50. -
Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions
Urman, N. M., Mirza, A., Atwood, S. X., Whitson, R. J., Sarin, K. Y., Tang, J. Y., & Oro, A. E. (2016). Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. PLOS ONE, 11(12). -
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.
Mirza, A. N., Fry, M. A., Urman, N. M., Atwood, S. X., Roffey, J., Ott, G. R., … Oro, A. E. (2017). Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight, 2(21). -
Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.
Whitson, R. J., Lee, A., Urman, N. M., Mirza, A., Yao, C. Y., Brown, A. S., … Oro, A. E. (2018). Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine, 24(3), 271–81. -
Factors That May Promote an Effective Local Research Environment
Wang, K., Lee, C. S., Marinkovich, M. P., Chang, H. Y., Oro, A. E., & Khavari, P. A. (2016). Factors That May Promote an Effective Local Research Environment. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(8), 1529–31. -
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata
Crispin, M. K., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI INSIGHT, 1(15). -
OVERCOMING ACQUIRED AND A PRIORI RESISTANCE TO SMO ANTAGONISTS THROUGH EPIGENETIC REGULATION OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT
Tang, Y., Schubert, S., Brian Nguyen, Masoud, S., Gholamin, S., Lee, A., … Cho, Y.-J. (2014). OVERCOMING ACQUIRED AND A PRIORI RESISTANCE TO SMO ANTAGONISTS THROUGH EPIGENETIC REGULATION OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
TGF-beta, Fibronectin and Integrin alpha5beta1 Promote Invasion in Basal Cell Carcinoma.
Kuonen, F., Surbeck, I., Sarin, K. Y., Dontenwill, M., Ruegg, C., Gilliet, M., … Gaide, O. (2018). TGF-beta, Fibronectin and Integrin alpha5beta1 Promote Invasion in Basal Cell Carcinoma. The Journal of Investigative Dermatology. -
Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility
Cho, H. G., Kuo, K. Y., Li, S., Bailey, I., Aasi, S., Chang, A. L. S., … Sarin, K. Y. (2018). Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility. JCI INSIGHT, 3(15). -
Actin polymerization controls cilia-mediated signaling
Drummond, M. L., Li, M., Tarapore, E., Nguyen, T. T. L., Barouni, B. J., Cruz, S., … Atwood, S. X. (2018). Actin polymerization controls cilia-mediated signaling. JOURNAL OF CELL BIOLOGY, 217(9), 3255–66. -
Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment.
Pattison, J. M., Melo, S. P., Piekos, S. N., Torkelson, J. L., Bashkirova, E., Mumbach, M. R., … Oro, A. E. (2018). Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nature Genetics. -
LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription.
Mirza, A. N., McKellar, S. A., Urman, N. M., Brown, A. S., Hollmig, T., Aasi, S. Z., & Oro, A. E. (2018). LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell. -
MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.
Brown, A. S., Meera, P., Altindag, B., Chopra, R., Perkins, E. M., Paul, S., … Oro, A. E. (2018). MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proceedings of the National Academy of Sciences of the United States of America. -
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.
Li, L., Wang, Y., Torkelson, J. L., Shankar, G., Pattison, J. M., Zhen, H. H., … Oro, A. E. (2019). TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Cell Stem Cell. -
Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma.
Kuonen, F., Huskey, N. E., Shankar, G., Jaju, P., Whitson, R. J., Rieger, K. E., … Oro, A. E. (2019). Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma. The Journal of Investigative Dermatology. -
Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression
Sekulic, A., Hainsworth, J. D., Lewis, K. D., Oro, A. E., Gesierich, A., Mortier, L., … Fisher, D. (2015). Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression.
Sekulic, A., Hainsworth, J. D., Lewis, K. D., Oro, A. E., Gesierich, A., Mortier, L., … Hauschild, A. (2014). Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Vismodegib in the treatment of patients with metastatic basal cell carcinoma (mBCC) and distant metastases: Survival in the pivotal phase II and phase I studies.
Lewis, K. D., Sekulic, A., Hauschild, A., Migden, M. R., Oro, A. E., LoRusso, P., … Von Hoff, D. D. (2014). Vismodegib in the treatment of patients with metastatic basal cell carcinoma (mBCC) and distant metastases: Survival in the pivotal phase II and phase I studies. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Regulation of growth by the patched tumor suppressor gene.
Wechsler-Reya, R., Milenkovic, L., Goodrich, L. V., Oro, A. E., Higgins, K. M., & Scott, M. P. (1998). Regulation of growth by the patched tumor suppressor gene. DEVELOPMENTAL BIOLOGY. ACADEMIC PRESS INC. -
AAV-Mediated Direct Somatic Genetic Correction of Epidermolysis Bullosa
Melo, S., Lisowski, L., Bashkirova, L., Kay, M. A., & Oro, A. E. (2013). AAV-Mediated Direct Somatic Genetic Correction of Epidermolysis Bullosa. MOLECULAR THERAPY. NATURE PUBLISHING GROUP. -
Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC)
Kwon, G. P., Ally, M. S., Bailey-Healy, I., Oro, A. E., Kim, J., Chang, A. L., … Tang, J. Y. (2016). Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 75(1), 213–15. -
Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma
Chang, A. L. S., & Oro, A. E. (2012). Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma. ARCHIVES OF DERMATOLOGY, 148(11), 1324–25. -
TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
Li, L., Wang, Y., Torkelson, J. L., Shankar, G., Pattison, J. M., Zhen, H. H., … Oro, A. E. (2019). TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. CELL STEM CELL, 24(2), 271-+. -
Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment
Pattison, J. M., Melo, S. P., Piekos, S. N., Torkelson, J. L., Bashkirova, E., Mumbach, M. R., … Oro, A. E. (2018). Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. NATURE GENETICS, 50(12), 1658-+. -
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma
Chiang, A., Tan, C. Z., Kuonen, F., Hodgkinson, L. M., Chiang, F., Cho, R. J., … Sarin, K. Y. (2019). Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. Journal of INVESTIGATIVE DERMATOLOGY | Original Article | Carcinogenesis/Tumorigenesis, 139(11). -
Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma
Kuonen, F., Huskey, N. E., Shankar, G., Jaju, P., Whitson, R. J., Rieger, K. E., … Oro, A. E. (2019). Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(7), 1439–48. -
LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription
Mirza, A. N., McKellar, S. A., Urman, N. M., Brown, A. S., Hollmig, T., Aasi, S. Z., & Oro, A. E. (2019). LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. CELL, 176(1-2), 198-+. -
Receptor protein tyrosine phosphatases control Purkinje neuron firing.
Brown, A. S., Meera, P., Quinones, G., Magri, J., Otis, T. S., Pulst, S. M., & Oro, A. E. (2019). Receptor protein tyrosine phosphatases control Purkinje neuron firing. Cell Cycle (Georgetown, Tex.), 1–7. -
Starve a cold, and perhaps a cancer.
Haensel, D., & Oro, A. E. (2020). Starve a cold, and perhaps a cancer. Nature Cell Biology. -
AP-1 and TGFSS cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma.
Yao, C. D., Haensel, D., Gaddam, S., Patel, T., Atwood, S. X., Sarin, K. Y., … Oro, A. E. (2020). AP-1 and TGFSS cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma. Nature Communications, 11(1), 5079. -
The Sky's the LEMit: New insights into nuclear structure regulation of transcription factor activity.
Mirza, A. N., Gonzalez, F., Ha, S. K., & Oro, A. E. (2020). The Sky's the LEMit: New insights into nuclear structure regulation of transcription factor activity. Current Opinion in Cell Biology, 68, 173–80. -
Dermatology in the postgenomic era - Harnessing human variation for personalized medicine
Oro, A. E. (2008). Dermatology in the postgenomic era - Harnessing human variation for personalized medicine. ARCHIVES OF DERMATOLOGY, 144(3), 389–391. -
Modulation of the Hedgehog signaling pathway in models of basal cell carcinoma by ATP-competitive PKCi inhibitors
Roffey, J., Dillon, C., Oro, A. E., Mirza, A. N., Sarin, K. Y., Aasi, S. Z., … Ator, M. (2018). Modulation of the Hedgehog signaling pathway in models of basal cell carcinoma by ATP-competitive PKCi inhibitors. MOLECULAR CANCER THERAPEUTICS. AMER ASSOC CANCER RESEARCH. -
MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias
Brown, A. S., Meera, P., Altindag, B., Chopra, R., Perkins, E. M., Paul, S., … Oro, A. E. (2018). MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(52), E12407–E12416. -
TGF beta, Fibronectin and Integrin alpha 5 beta 1 Promote Invasion in Basal Cell Carcinoma
Kuonen, F., Surbeck, I., Sarin, K. Y., Dontenwill, M., Ruegg, C., Gilliet, M., … Gaide, O. (2018). TGF beta, Fibronectin and Integrin alpha 5 beta 1 Promote Invasion in Basal Cell Carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138(11), 2432–2442. -
Efficacy and safety of the hedgehog pathway inhibitor vismodegib in patients with advanced basal cell carcinoma (BCC): ERIVANCE BCC study update
Sekulic, A., Migden, M. R., Oro, A. E., Lewis, K. D., Hainsworth, J. D., Yoo, S., … Hauschild, A. (2012). Efficacy and safety of the hedgehog pathway inhibitor vismodegib in patients with advanced basal cell carcinoma (BCC): ERIVANCE BCC study update. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
A pivotal multicenter trial evaluating efficacy and safety of the hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with advanced basal cell carcinoma
Sekulic, A., Oro, A. E., Solomon, J. A., Hainsworth, J. D., Lewis, K., Dirix, L., & Migden, M. R. (2012). A pivotal multicenter trial evaluating efficacy and safety of the hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with advanced basal cell carcinoma. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
C-FOS drives reversible basal to squamous cell carcinoma transition
Kuonen, F., Li, N., Haensel, D., Patel, T., Gaddam, S., Yerly, L., … Oro, A. (2021). C-FOS drives reversible basal to squamous cell carcinoma transition. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ELSEVIER SCIENCE INC. -
Phase II Open-Label, Single-Arm Trial to Investigate the Efficacy and Safety of Topical Remetinostat Gel in Patients with Basal Cell Carcinoma.
Kilgour, J. M., Shah, A., Urman, N. M., Eichstadt, S., Do, H. N., Bailey, I., … Sarin, K. Y. (2021). Phase II Open-Label, Single-Arm Trial to Investigate the Efficacy and Safety of Topical Remetinostat Gel in Patients with Basal Cell Carcinoma. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Biomedical Data Commons (BMDC) prioritizes B-lymphocyte non-coding genetic variants in Type 1 Diabetes.
Piekos, S. N., Gaddam, S., Bhardwaj, P., Radhakrishnan, P., Guha, R. V., & Oro, A. E. (2021). Biomedical Data Commons (BMDC) prioritizes B-lymphocyte non-coding genetic variants in Type 1 Diabetes. PLoS Computational Biology, 17(9), e1009382. -
c-FOS drives reversible basal to squamous cell carcinoma transition.
Kuonen, F., Li, N. Y., Haensel, D., Patel, T., Gaddam, S., Yerly, L., … Oro, A. E. (2021). c-FOS drives reversible basal to squamous cell carcinoma transition. Cell Reports, 37(1), 109774. -
Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Matheus, F., Raveh, T., Oro, A. E., Wernig, M., & Drukker, M. (2022). Is hypoimmunogenic stem cell therapy safe in times of pandemics? Stem Cell Reports. -
Gibbin mesodermal regulation patterns epithelial development.
Collier, A., Liu, A., Torkelson, J., Pattison, J., Gaddam, S., Zhen, H., … Oro, A. E. (2022). Gibbin mesodermal regulation patterns epithelial development. Nature. -
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.
Shue, Y. T., Drainas, A. P., Li, N. Y., Pearsall, S. M., Morgan, D., Sinnott-Armstrong, N., … Sage, J. (2022). A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nature Communications, 13(1), 2690. -
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
Bartl, J., Zanini, M., Bernardi, F., Forget, A., Blumel, L., Talbot, J., … Remke, M. (2022). The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nature Communications, 13(1), 4061. -
LY6D marks pre-existing resistant basosquamous tumor subpopulations.
Haensel, D., Gaddam, S., Li, N. Y., Gonzalez, F., Patel, T., Cloutier, J. M., … Oro, A. E. (2022). LY6D marks pre-existing resistant basosquamous tumor subpopulations. Nature Communications, 13(1), 7520. -
GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development.
Collier, A. E., Piekos, S. N., Liu, A., Pattison, J. M., Felix, F., Bailetti, A. A., … Oro, A. E. (2023). GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development. IScience, 26(3), 106125. -
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche.
Haensel, D., Daniel, B., Gaddam, S., Pan, C., Fabo, T., Bjelajac, J., … Oro, A. E. (2023). Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche. Nature Communications, 14(1), 2685. -
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases.
Ober-Reynolds, B., Wang, C., Ko, J. M., Rios, E. J., Aasi, S. Z., Davis, M. M., … Greenleaf, W. J. (2023). Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases. Nature Genetics. -
Acquisition of drug resistance in basal cell nevus syndrome tumors through basal to squamous cell carcinoma transition.
Jussila, A. R., Haensel, D., Gaddam, S., & Oro, A. E. (2023). Acquisition of drug resistance in basal cell nevus syndrome tumors through basal to squamous cell carcinoma transition. BioRxiv : the Preprint Server for Biology. -
The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations.
Yang, Y., Seninge, L., Wang, Z., Oro, A., Stuart, J. M., & Ding, H. (2024). The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations. Scientific Reports, 14(1), 11794. -
A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa.
Neumayer, G., Torkelson, J. L., Li, S., McCarthy, K., Zhen, H. H., Vangipuram, M., … Oro, A. E. (2024). A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. Nature Communications, 15(1), 5834. -
Basal-to-inflammatory transition and tumor resistance via crosstalk with a pro-inflammatory stromal niche.
Li, N. Y., Zhang, W., Haensel, D., Jussila, A. R., Pan, C., Gaddam, S., … Oro, A. E. (2024). Basal-to-inflammatory transition and tumor resistance via crosstalk with a pro-inflammatory stromal niche. Nature Communications, 15(1), 8134. -
Basal-to-inflammatory transition and tumor resistance via crosstalk with a proinflammatory stromal niche
Li, N. Y., Zhang, W., Haensel, D., Jussila, A., Pan, C., Gaddam, S., … Oro, A. (2024). Basal-to-inflammatory transition and tumor resistance via crosstalk with a proinflammatory stromal niche. Nature Communications, 15.
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MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Topical Itraconazole in Treating Patients With Basal Cell Cancer
- Tofacitinib for the Treatment of Alopecia Areata and Its Variants
- Vismodegib in Treating Patients With Basal Cell Carcinoma (BCC)
- Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors
- Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma
- A Phase 1 Study of IPI-926 in Patients With Advanced and/or Metastatic Solid Tumor Malignancies
- A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma
- A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma
Practice Locations
High-Risk Skin Cancer Clinic Redwood City, CA
Redwood City, CAHigh-Risk Skin Cancer Clinic
450 Broadway Street, Pavilion B 4th Floor
Redwood City , CA 94063
Make An Appointment More Clinic Information Getting HereHair Loss Clinic Redwood City, CA
Redwood City, CAHair Loss Clinic
450 Broadway Street, Pavilion B 4th Floor
Redwood City , CA 94063
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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