Publications

• Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
  Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., Scott, M. P., & Epstein, E. H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. NATURE MEDICINE, 5(11), 1285–1291.
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• Laminin-10 is crucial for hair morphogenesis
  Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., Gao, J., … Marinkovich, M. P. (2003). Laminin-10 is crucial for hair morphogenesis. EMBO JOURNAL, 22(10), 2400–2410.
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• Conditional telomerase induction causes proliferation of hair follicle stem cells Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., … Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. NATURE, 436(7053), 1048–52.
  
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• Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation DeRouen, M. C., Zhen, H., Tan, S. H., Williams, S., Marinkovich, M. P., & Oro, A. E. (2010). Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC DEVELOPMENTAL BIOLOGY, 10.
  
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• Role of the basement membrane zone in skin development. Oro, A. E. (2008). Role of the basement membrane zone in skin development. Journal of Investigative Dermatology, 128(E2), E11–2.
  
• Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip Yucel, G., & Oro, A. E. (2011). Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip. CELL, 144(3), 319–21.
  
• SnapShot: Hair Follicle Stem Cells Woo, W.-M., & Oro, A. E. (2011). SnapShot: Hair Follicle Stem Cells. CELL, 146(2), 334–U159.
  
• Neuropilins are positive regulators of Hedgehog signal transduction Hillman, R. T., Feng, B. Y., Ni, J., Woo, W.-M., Milenkovic, L., Gephart, M. G. H., … Scott, M. P. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. GENES & DEVELOPMENT, 25(22), 2333–46.
  
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• Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma Sekulic, A., Migden, M. R., Oro, A. E., Dirix, L., Lewis, K. D., Hainsworth, J. D., … Hauschild, A. (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2171–2179.
  
• Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma Gomez-Ospina, N., Chang, A. L. S., Qu, K., & Oro, A. E. (2012). Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2233–2234.
  
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• GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature, 494(7438), 484–88.
  
• Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. Journal of Visualized Experiments : JoVE, (72).
  
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• Hedgehog/patched signaling in animal development and disease Scott, M. P., Goodrich, L. V., Higgins, K. M., Johnson, R. L., Milenkovic, L., & Oro, A. E. (1997). Hedgehog/patched signaling in animal development and disease. FASEB JOURNAL, 11(9), A1302–A1302.
  
• Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. Fan, H., Oro, A. E., Scott, M. P., & Khavari, P. A. (1997). Induction of features of basal cell epithelioma in transgenic human skin expressing sonic Hedgehog in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108(4), 38–38.
  
• Hedgehog pathway inhibition and the race against tumor evolution Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2013). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 45–49.
  
• A perivascular stem cell niche in the hair follicle Xiao, Y., Woo, W., Terunuma, A., Oro, A. E., Vogel, J. C., & Brownell, I. (2012). A perivascular stem cell niche in the hair follicle. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC: NATURE PUBLISHING GROUP.
  
• Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 Gonzalez-Quevedo, R., Shoffer, M., Horng, L., & Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124(4), A103–A103.
  
• MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE Oro, A. E., Newton, K. J., & Walbot, V. (1985). MOLECULAR ANALYSIS OF THE INHERITANCE AND STABILITY OF THE MITOCHONDRIAL GENOME OF AN INBRED LINE OF MAIZE. THEORETICAL AND APPLIED GENETICS, 70(3), 287–293.
  
• Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., Dhamdhere, G. R., … Helms, J. A. (2013). Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing. PLOS ONE, 8(10).
  
• Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin. Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., Lara, M. F., … Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing ß-Catenin. Stem Cells , 32(1), 85–92.
  
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• Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. Melo, S. P., Lisowski, L., Bashkirova, E., Zhen, H. H., Chu, K., Keene, D. R., … Oro, A. E. (2014). Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant. Molecular Therapy : the Journal of the American Society of Gene Therapy, 22(4), 725–33.
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature Medicine, 20(7), 732–40.
  
• Advanced treatment for basal cell carcinomas. Atwood, S. X., Whitson, R. J., & Oro, A. E. (2014). Advanced treatment for basal cell carcinomas. Cold Spring Harbor Perspectives in Medicine, 4(7).
  
• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., … Cho, Y.-J. (2014). Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. NATURE MEDICINE, 20(7), 732–40.
  
• Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa Sebastiano, V., Zhen, H. H., Derafshi, B. H., Bashkirova, E., Melo, S. P., Wang, P., … Oro, A. E. (2014). Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. SCIENCE TRANSLATIONAL MEDICINE, 6(264).
  
• Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration Woo, W.-M., Atwood, S. X., Zhen, H. H., & Oro, A. E. (2013). Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72).
  
• Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Atwood, S. X., Sarin, K. Y., Whitson, R. J., Li, J. R., Kim, G., Rezaee, M., … Tang, J. Y. (2015). Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Cancer Cell, 27(3), 342–53.
  
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• An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Ally, M. S., Aasi, S., Wysong, A., Teng, C., Anderson, E., Bailey-Healy, I., … Tang, J. Y. (2014). An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. Journal of the American Academy of Dermatology, 71(5), 904–11 e1.
  
• Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. Ally, M. S., Ransohoff, K., Sarin, K., Atwood, S. X., Rezaee, M., Bailey-Healy, I., … Colevas, A. D. (2016). Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. JAMA Dermatology, 152(4), 452–56.
  
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• Role of the Basement Membrane Zone in Skin Development. Oro, A. E. (2008). Role of the Basement Membrane Zone in Skin Development. Journal of Investigative Dermatology, 128, E11–2.
  
• GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas Atwood, S. X., Li, M., Lee, A., Tang, J. Y., & Oro, A. E. (2013). GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. NATURE, 494(7438), 484–88.
  
• Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. Kennedy Crispin, M., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1(15).
  
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• Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. Mirza, A. N., Fry, M. A., Urman, N. M., Atwood, S. X., Roffey, J., Ott, G. R., … Oro, A. E. (2017). Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight, 2(21).
  
• Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Whitson, R. J., Lee, A., Urman, N. M., Mirza, A., Yao, C. Y., Brown, A. S., … Oro, A. E. (2018). Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine, 24(3), 271–81.
  
• Factors That May Promote an Effective Local Research Environment Wang, K., Lee, C. S., Marinkovich, M. P., Chang, H. Y., Oro, A. E., & Khavari, P. A. (2016). Factors That May Promote an Effective Local Research Environment. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(8), 1529–31.
  
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• Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility Cho, H. G., Kuo, K. Y., Li, S., Bailey, I., Aasi, S., Chang, A. L. S., … Sarin, K. Y. (2018). Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility. JCI INSIGHT, 3(15).
  
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• Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Pattison, J. M., Melo, S. P., Piekos, S. N., Torkelson, J. L., Bashkirova, E., Mumbach, M. R., … Oro, A. E. (2018). Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nature Genetics.
  
• LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Mirza, A. N., McKellar, S. A., Urman, N. M., Brown, A. S., Hollmig, T., Aasi, S. Z., & Oro, A. E. (2018). LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell.
  
• MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Brown, A. S., Meera, P., Altindag, B., Chopra, R., Perkins, E. M., Paul, S., … Oro, A. E. (2018). MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proceedings of the National Academy of Sciences of the United States of America.
  
• TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Li, L., Wang, Y., Torkelson, J. L., Shankar, G., Pattison, J. M., Zhen, H. H., … Oro, A. E. (2019). TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Cell Stem Cell.
  
• Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma. Kuonen, F., Huskey, N. E., Shankar, G., Jaju, P., Whitson, R. J., Rieger, K. E., … Oro, A. E. (2019). Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma. The Journal of Investigative Dermatology.
  
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