Treatment Alternatives in iSGS (NoAAC PR-02 Study)

Trial ID or NCT#



recruiting iconRECRUITING


The study is aimed at answering the questions; (1) How well do the most commonly used treatments in iSGS work? and (2) What quality-of-life trade-offs are associated with each approach? With the results of this trial, the investigators hope to provide information to iSGS patients: (1) Given my personal characteristics, conditions, and preferences, what should I expect will happen to me? and (2) What are my options, and what are the potential benefits and harms of these options?

Official Title

Treatment Alternatives in Adult Rare Disease; Assessment of Options in Idiopathic Subglottic Stenosis North American Airway Collaborative PR-02 Study (NoAAC PR-02 Study)

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Greater than 18 years of age. - The lesion must involve the subglottis.
Exclusion Criteria:
  1. - Less than 18 years of age - Patients without capacity to consent for themselves - History of significant laryngotracheal traumatic injury. - History of endotracheal intubation or tracheotomy within 2 years of presentation. - Major anterior neck surgery. - History of neck irradiation. - History of caustic or thermal injuries to the laryngotracheal complex. - History of a clinically diagnosed vasculitis or collage vascular disease. - Positive antinuclear cytoplasmic antibody titers.


Edward J. Damrose, MD, FACS
Edward J. Damrose, MD, FACS
Laryngologist, Head and neck surgeon, Ear, nose, and throat specialist, Head and neck oncologist
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Anesthesiology, Perioperative & Pain Medicine

Contact us to find out if this trial is right for you.