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Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Han, X. J., Pin, S. S., Burris, K., Fung, L. K., Huang, S., Taber, M. T., Zhang, J., Dubowchik, G. M. 2005; 15 (18): 4029-4032
Abstract
8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (K(i) = 23 nM).
View details for DOI 10.1016/j.bmcl.2005.06.028
View details for Web of Science ID 000231493400009
View details for PubMedID 15982881