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Abstract
The Medtronic predictive low-glucose management (PLGM) algorithm automatically stops insulin delivery when sensor glucose (SG) is predicted to reach or fall below a preset low-glucose value within the next 30?min, and resumes delivery after hypoglycemia recovery. The present study evaluated the PLGM algorithm performance of the MiniMed™ 670G system SmartGuard™ "suspend before low" feature in children aged 7-13 years with type 1 diabetes (T1D).Participants (N?=?105, mean?±?standard deviation of 10.8?±?1.8 years) underwent an overnight in-clinic evaluation of the "suspend before low" feature with a preset low limit of 65?mg/dL. After exercise, frequent sample testing (FST) was conducted every 5?min if values were <70?mg/dL; every 15?min if 70-80?mg/dL; and every 30?min if >80?mg/dL. First-day performance of the Guardian™ Sensor 3 glucose sensor and continuous glucose monitoring system was also evaluated.Activation of the "suspend before low" feature occurred in 79 of the 105 participants, 79.7% (63/79) did not result in SG falling below 65?mg/dL. Mean glucose at activation was 102?±?19?mg/dL and the initial insulin suspension duration was 87.5?±?32.7?min. Four hours after insulin resumption, mean reference glucose was 130?±?42?mg/dL. Mean absolute relative difference between the FST reference glucose and SG values on the first day of sensor wear was 11.4%. For the 26 participants in whom the "suspend before low" feature did not activate, none involved a reference glucose value =65?mg/dL, suggesting that the PLGM algorithm performed as intended.In children aged 7-13 years with T1D, the "suspend before low" feature of the MiniMed 670G system demonstrated a hypoglycemia prevention rate of nearly 80% after exercise and did not involve rebound hyperglycemia. There were no events of severe hypoglycemia during the evaluation.
View details for PubMedID 30299976