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Abstract
The treatment of food allergy (FA) has traditionally relied on avoidance of the offending food(s) and use of emergency medications in the event of accidental exposures. However, this longstanding paradigm is beginning to shift, as a variety of treatment approaches have been and are being developed. In this manuscript, we seek to provide an overview of the past, present, and future landscape of interventional clinical trials for the treatment of FA. We focus on specific issues related to participant characteristics, protocol design, and study endpoints in the key clinical trials in the literature and examine how differences between studies may impact the clinical significance of the study results. We then provide recommendations for the optimization of future trial designs and focus on specific unmet needs in this rapidly evolving field.
View details for DOI 10.1016/j.jaci.2022.08.008
View details for PubMedID 35998790