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Abstract
To investigate the pregnancy and neonatal outcomes of letrozole-stimulated frozen embryo transfer (LTZ-FET) cycles compared with natural FET cycles (NC-FET).Our retrospective cohort included all LTZ-FET (n?=?161) and NC-FET (n?=?575) cycles that transferred a single euploid autologous blastocyst from 2016 to 2020 at Stanford Fertility Center. The LTZ-FET protocol entailed 5 mg of daily letrozole for 5 days starting on cycle day 2 or 3. Outcomes were compared using absolute standardized differences (ASD), in which a larger ASD signifies a larger difference. Multivariable regression models adjusted for confounders: maternal age, BMI, nulliparity, embryo grade, race, infertility diagnosis, and endometrial thickness.The demographic and clinical characteristics were overall similar. A greater proportion of the letrozole cohort was multiparous, transferred high-graded embryos, and had ovulatory dysfunction. The cohorts had similar pregnancy rates (67.1% LTZ vs 62.1% NC; aOR 1.31, P?=?0.21) and live birth rates (60.9% LTZ vs 58.6% NC; aOR 1.17, P?=?0.46). LTZ-FET neonates on average were born 5.7 days earlier (P?
View details for DOI 10.1007/s10815-023-02759-2
View details for PubMedID 36849755
View details for PubMedCentralID 8417182