Timothy Angelotti MD, PhD

Anesthesiologist

Associate Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center

Anesthesia Preoperative Evaluation Clinic

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6412
Learn More About the Clinic » Getting Here » Make An Appointment

Professional Education

Internship: St Joseph's Mercy Hospital (1995) MI

Residency: Duke University Medical Center (1999) NC

Fellowship: Stanford University School of Medicine (2000) CA

Board Certification: Anesthesia, American Board of Anesthesiology (2000)

Board Certification: Critical Care Medicine, American Board of Anesthesiology (2001)

Medical Education: University of Michigan School of Medicine (1994) MI

MD, University of Michigan (1994)

PhD, University of Michigan, Pharmacology (1994)

Honors & Awards

Best of Meeting Award (82nd Annual IARS Congress), IARS (2008)

Alexander von Humboldt Foundation Post-Doctoral Fellowship, Alexander von Humboldt Foundation (1995-1996)

Dean's Award for Research Excellence, University of Michigan (1994)

Administrative Appointments

Medical Director - Critical Care Transport, Stanford Life Flight (2000 - Present)

Associate Medical Director, MICU, Stanford University Medical Center (2005 - Present)

Common alpha 2A and alpha 2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking
Hurt, C. M., Sorensen, M. W., & Angelotti, T. (2014). Common alpha 2A and alpha 2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 387(6), 569-579.

REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues
Hurt, C. M., Bjork, S., Ho, V. K., Gilsbach, R., Hein, L., & Angelotti, T. (2014). REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues. BRAIN RESEARCH, 1545, 12-22.

REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity
Bjork, S., Hurt, C. M., Ho, V. K., & Angelotti, T. (2013). REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity. PLOS ONE, 8(10).

Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs
Hurt, C. M., Ho, V. K., & Angelotti, T. (2013). Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs. G PROTEIN COUPLED RECEPTORS: TRAFFICKING AND OLIGOMERIZATION, 521, 171-187.

Regulation of G-Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal
Angelotti, T., Daunt, D., Shcherbakova, O. G., Kobilka, B., & Hurt, C. M. (2010). Regulation of G-Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal. TRAFFIC, 11(4), 560-578.

Differential targeting and function of alpha(2A) and alpha(2C) adrenergic receptor subtypes in cultured sympathetic neurons
Brum, P. C., Hurt, C. M., Shcherbakova, O. G., Kobilka, B., & Angelotti, T. (2006). Differential targeting and function of alpha(2A) and alpha(2C) adrenergic receptor subtypes in cultured sympathetic neurons. NEUROPHARMACOLOGY, 51(3), 397-413.

Verification of endotracheal tube placement by prehospital providers: is a portable fiberoptic bronchoscope of value?
Angelotti, T., Weiss, E. L., Lemmens, H. Jm., & Brock-Utne, J. (2006). Verification of endotracheal tube placement by prehospital providers: is a portable fiberoptic bronchoscope of value?. Air medical journal, 25(2), 74-78.

Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of alpha(2)-Adrenergic Responses Is because of Ligand-selective Internalization
Lu, R., Li, Y., Zhang, Y., Chen, Y., Shields, A. D., & Wang, Q. (2009). Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of alpha(2)-Adrenergic Responses Is because of Ligand-selective Internalization. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(19), 13233-13243.

Sex-specific modulation of spinal nociception by alpha(2)-adrenoceptors: Differential regulation by estrogen and testosterone
Thompson, A. D., Angelotti, T., Nag, S., & Mokha, S. S. (2008). Sex-specific modulation of spinal nociception by alpha(2)-adrenoceptors: Differential regulation by estrogen and testosterone. NEUROSCIENCE, 153(4), 1268-1277.

New methods for direct verification of correct endotracheal tube placement
Angelotti, T., & Brock-Utne, J. (2007). New methods for direct verification of correct endotracheal tube placement. ANESTHESIA AND ANALGESIA, 105(4), 1168-1168.

Pharmacology and mechanism of action of pregabalin: The calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery
Taylor, C. P., Angelotti, T., & Fauman, E. (2007). Pharmacology and mechanism of action of pregabalin: The calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery. EPILEPSY RESEARCH, 73(2), 137-150.

Anesthetic implications of a near-lethal sodium azide exposure
Angelotti, T., Mireles, S., & McMahon, D. (2007). Anesthetic implications of a near-lethal sodium azide exposure. ANESTHESIA AND ANALGESIA, 104(1), 229-230.

Molecular insights into alpha2 adrenergic receptor function: Clinical implications
Hurt CM, & Angelotti T. (2007). Molecular insights into alpha2 adrenergic receptor function: Clinical implications. Seminars in Anesthesia, Perioperative Medicine and Pain, 26(1).

Anesthesia for older patients with hypertrophic cardiomyopathy: is there cause for concern?
Angelotti, T., Fuller, A., Rivera, L., & Schmiesing, C. (2005). Anesthesia for older patients with hypertrophic cardiomyopathy: is there cause for concern?. JOURNAL OF CLINICAL ANESTHESIA, 17(6), 478-481.

Diagnosis of an unsuspected maternal hemorrhage via fetal heart rate tracing
Doyle, C., & Angelotti, T. (2004). Diagnosis of an unsuspected maternal hemorrhage via fetal heart rate tracing. JOURNAL OF CLINICAL ANESTHESIA, 16(6), 465-468.

Alpha2A and alpha2C adrenoceptors undergo agonist stimulated internalization when expressed in neurons: Role of cell type in signaling and trafficking of G-protein coupled receptors.
Angelotti T, Hurt CM, Brum PC, Lee TW, Feng FY, & Kobilka B. (2004). Alpha2A and alpha2C adrenoceptors undergo agonist stimulated internalization when expressed in neurons: Role of cell type in signaling and trafficking of G-protein coupled receptors. Mol Pharm (in preparation)..

Right subclavian artery injury
Angelotti, T., & Amador, E. R. (2003). Right subclavian artery injury. ANESTHESIA AND ANALGESIA, 96(4), 1237-1237.

Nodular invasive tracheobronchitis due to Aspergillus in a patient with systemic lupus erythematosus
Angelotti, T., Krishna, G., Scott, J., Berry, G., & Weinacker, A. (2002). Nodular invasive tracheobronchitis due to Aspergillus in a patient with systemic lupus erythematosus. LUPUS, 11(5), 325-328.

Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
Kubota, Y., Angelotti, T., Niederfellner, G., Herbst, R., & Ullrich, A. (1998). Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases. CELL GROWTH & DIFFERENTIATION, 9(3), 247-256.

The "VH1-like" dual-specificity protein tyrosine phosphatases
Martell, K. J., Angelotti, T., & Ullrich, A. (1998). The "VH1-like" dual-specificity protein tyrosine phosphatases. MOLECULES AND CELLS, 8(1), 2-11.

Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha 2/delta subunit
Angelotti, T., & Hofmann, F. (1996). Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha 2/delta subunit. FEBS LETTERS, 397(2-3), 331-337.

Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acid(A) receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits
Lin, Y. F., ANGELOTTI, T. P., Dudek, E. M., Browning, M. D., & Macdonald, R. L. (1996). Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acid(A) receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits. MOLECULAR PHARMACOLOGY, 50(1), 185-195.

Functional expression of recombinant GABAA receptor channels in L929 fibroblasts.
Macdonald, R. L., Saxena, N. C., & ANGELOTTI, T. P. (1996). Functional expression of recombinant GABAA receptor channels in L929 fibroblasts. Epilepsy research. Supplement, 12, 177-185.

THE TYPE-II ISOFORM OF CGMP-DEPENDENT PROTEIN-KINASE IS DIMERIC AND POSSESSES REGULATORY AND CATALYTIC PROPERTIES DISTINCT FROM THE TYPE-I ISOFORMS
Gamm, D. M., Francis, S. H., ANGELOTTI, T. P., Corbin, J. D., & Uhler, M. D. (1995). THE TYPE-II ISOFORM OF CGMP-DEPENDENT PROTEIN-KINASE IS DIMERIC AND POSSESSES REGULATORY AND CATALYTIC PROPERTIES DISTINCT FROM THE TYPE-I ISOFORMS. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(45), 27380-27388.

Fluorescent b-galactosidase staining of transfected cells prior to patch clamp recording.
Angelotti, Tp., & Macdonald RL. (1994). Fluorescent b-galactosidase staining of transfected cells prior to patch clamp recording. AxoBits, 15(15).

ENHANCEMENT OF RECOMBINANT GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR CURRENTS BY CHRONIC ACTIVATION OF CAMP-DEPENDENT PROTEIN-KINASE
ANGELOTTI, T. P., Uhler, M. D., & Macdonald, R. L. (1993). ENHANCEMENT OF RECOMBINANT GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR CURRENTS BY CHRONIC ACTIVATION OF CAMP-DEPENDENT PROTEIN-KINASE. MOLECULAR PHARMACOLOGY, 44(6), 1202-1210.

NATIVE AND RECOMBINANT GABA(A) RECEPTOR CHANNELS
Macdonald, R. L., & ANGELOTTI, T. P. (1993). NATIVE AND RECOMBINANT GABA(A) RECEPTOR CHANNELS. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 3(5-6), 352-373.

ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ANALYSIS OF TRANSIENT SINGLE-CELL EXPRESSION UTILIZING A FLUORESCENT SUBSTRATE MARKER GENE TECHNIQUE
ANGELOTTI, T. P., Uhler, M. D., & Macdonald, R. L. (1993). ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ANALYSIS OF TRANSIENT SINGLE-CELL EXPRESSION UTILIZING A FLUORESCENT SUBSTRATE MARKER GENE TECHNIQUE. JOURNAL OF NEUROSCIENCE, 13(4), 1418-1428.

ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ALPHA-1-BETA-1-SUBUNIT AND ALPHA-1-BETA-1-GAMMA-2S-SUBUNIT PRODUCE UNIQUE ION CHANNELS WITH DISSIMILAR SINGLE-CHANNEL PROPERTIES
ANGELOTTI, T. P., & Macdonald, R. L. (1993). ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ALPHA-1-BETA-1-SUBUNIT AND ALPHA-1-BETA-1-GAMMA-2S-SUBUNIT PRODUCE UNIQUE ION CHANNELS WITH DISSIMILAR SINGLE-CHANNEL PROPERTIES. JOURNAL OF NEUROSCIENCE, 13(4), 1429-1440.

MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A ALLELIC VARIANT OF THE RAT ALPHA-6 GABA-A RECEPTOR SUBUNIT
ANGELOTTI, T. P., Tan, F., Chahine, K. G., & Macdonald, R. L. (1992). MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A ALLELIC VARIANT OF THE RAT ALPHA-6 GABA-A RECEPTOR SUBUNIT. MOLECULAR BRAIN RESEARCH, 16(1-2), 173-178.

KINETIC-PROPERTIES OF ALPHA-1-BETA-1-GAMMA-AMINOBUTYRIC ACID(A) RECEPTOR CHANNELS EXPRESSED IN CHINESE-HAMSTER OVARY CELLS - REGULATION BY PENTOBARBITAL AND PICROTOXIN
Porter, N. M., ANGELOTTI, T. P., Twyman, R. E., & Macdonald, R. L. (1992). KINETIC-PROPERTIES OF ALPHA-1-BETA-1-GAMMA-AMINOBUTYRIC ACID(A) RECEPTOR CHANNELS EXPRESSED IN CHINESE-HAMSTER OVARY CELLS - REGULATION BY PENTOBARBITAL AND PICROTOXIN. MOLECULAR PHARMACOLOGY, 42(5), 872-881.

REGULATION OF GABA-A-RECEPTOR CHANNELS BY ANTICONVULSANT AND CONVULSANT DRUGS AND BY PHOSPHORYLATION
Macdonald, R. L., Twyman, R. E., RYANJASTROW, T., ANGELOTTI, T. P., Wilson, W. A., & Ticku, M. K. (1992). REGULATION OF GABA-A-RECEPTOR CHANNELS BY ANTICONVULSANT AND CONVULSANT DRUGS AND BY PHOSPHORYLATION. EPILEPSY RESEARCH, 265-277.

BIOTINYLATED GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ANALOGS - EFFECT OF LINKAGE CHEMISTRY ON ACTIVITY AND BINDING
ANGELOTTI, T. P., Clarke, M. F., Longino, M. A., & Emerson, S. G. (1991). BIOTINYLATED GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ANALOGS - EFFECT OF LINKAGE CHEMISTRY ON ACTIVITY AND BINDING. BIOCONJUGATE CHEMISTRY, 2(6), 466-474.