Biography
My interest in medicine and research was triggered by my mother’s battle with chronic hepatitis C, which made me realize the transformational power of biomedical research in treating patients. Therefore, my career goal is to become a physician scientist in the field of gastroenterology and hepatology dedicated to translating discoveries in the laboratory into novel medical treatment modalities. My research focus is alterations in phosphoinositides signaling and its pathogenesis in cancers of the hepatobiliary and luminal GI tract with the goal to identify novel targets for therapeutic intervention. I also have a particular interest in understanding the interface between chronic viral infection and cancer through studying how the innate and adaptive immune system are perturbed in chronic viral infections
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Professional Summary
Education & Certifications
- Fellowship: Stanford University Division of Gastroenterology and Hepatology (2022) CA
- Board Certification: American Board of Internal Medicine, Gastroenterology (2022)
- Medical Education: Stanford University School of Medicine (2016) CA
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- Board Certification: American Board of Internal Medicine, Internal Medicine (2019)
- Residency: Case Western Reserve University Internal Medicine Residency (2018) OH
Honors & Awards
- Bioengineering Capstone Design Winner, UCLA Bioengineering (2008)
- Chem-H Physician Scientist Postdoctoral Fellowship, Stanford Chem-H (2018)
- Dean's Prize for Outstanding Undergraduate Researcher, UCLA Dean's office (2007)
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- Departmental Citation for top graduate, Outstanding Bachelor of Science, UCLA Bioengineering (2008)
- Gates Millennium Scholar, Bill and Melinda Gates Foundation (2004)
- HHMI Medical Student Research Fellowship, Howard Hughes Medical Institute (2010)
- International Achievement Summit Delegate, Academy of Achievement (2011)
- Nation Research Service Fellowship for MD/PhD (F30), NIH (2013)
- Paul and Daisy Soros Fellowships for New Americans, The Soros Foundation (2009)
- Phi Beta Kappa, UCLA (2008)
- Summa Cum Laude, UCLA (2008)
- Tau Beta Pi, UCLA School of Engineering (2007)
Administrative Appointments
- Deputy Director, ViRx@Stanford - Stanford Biosecurity and Pandemic Preparedness Initiative (2022 - Present)
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Publications
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Simplified RNA secondary structure mapping by automation of SHAPE data analysis
Pang, P. S., Elazar, M., Pham, E. A., & Glenn, J. S. (2011). Simplified RNA secondary structure mapping by automation of SHAPE data analysis. NUCLEIC ACIDS RESEARCH, 39(22). -
Structural Map of a MicroRNA-122: Hepatitis C Virus Complex
Pang, P. S., Pham, E. A., Elazar, M., Patel, S. G., Eckart, M. R., & Glenn, J. S. (2012). Structural Map of a MicroRNA-122: Hepatitis C Virus Complex. JOURNAL OF VIROLOGY, 86(2), 1250–54. -
Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction
Nishimura, T., Hu, Y., Wu, M., Pham, E., Suemizu, H., Elazar, M., … Peltz, G. (2013). Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 344(2), 388–96. -
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STRUCTURAL INSIGHTS INTO THE MECHANISM OF MICRORNA-MODULATED HCV TRANSLATION
Pang, P. S., Pham, E. A., Patel, S. G., Winters, M. A., Eckart, M. R., & Glenn, J. S. (2010). STRUCTURAL INSIGHTS INTO THE MECHANISM OF MICRORNA-MODULATED HCV TRANSLATION. HEPATOLOGY. BOSTON,MA,MA,MA,MA,MA,MA,MA: WILEY-BLACKWELL. -
An HCV IRES element regulates viral replication independent of translation
Pham, E. A., Cho, N.-J., Pang, P. S., Leveque, V. J., Ma, H., Klumpp, K., & Glenn, J. (2012). An HCV IRES element regulates viral replication independent of translation. Presented at the 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), BOSTON,MA,MA,MA,MA,MA,MA,MA: WILEY-BLACKWELL. -
Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome.
Cho, N.-J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., … Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616–25. -
Task-Shifting: An Approach to Decentralized Hepatitis C Treatment in Medically Underserved Areas
Jayasekera, C. R., Perumpail, R. B., Chao, D. T., Pham, E. A., Aggarwal, A., Wong, R. J., & Ahmed, A. (2015). Task-Shifting: An Approach to Decentralized Hepatitis C Treatment in Medically Underserved Areas. DIGESTIVE DISEASES AND SCIENCES, 60(12), 3552–57. -
A New Standard of Care? Standard Dose Sofosbuvir in an HCV-Infected Liver Transplant Recipient Undergoing Hemodialysis
Perumpail, R. B., Wong, R. J., Pham, E. A., Higgins, J. P., Daugherty, T. J., & Ahmed, A. (2016). A New Standard of Care? Standard Dose Sofosbuvir in an HCV-Infected Liver Transplant Recipient Undergoing Hemodialysis. DIGESTIVE DISEASES AND SCIENCES, 61(1), 39–41. -
Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer.
Cho, N.-J., Pham, E. A., Hagey, R. J., Lévêque, V. J., Ma, H., Klumpp, K., & Glenn, J. S. (2016). Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer. ACS Central Science, 2(7), 456–66. -
Nonalcoholic Fatty Liver Disease: Epidemiology, Natural History, and Diagnostic Challenges.
Cholankeril, G., Perumpail, R. B., Pham, E. A., Ahmed, A., & Harrison, S. A. (2016). Nonalcoholic Fatty Liver Disease: Epidemiology, Natural History, and Diagnostic Challenges. Hepatology , 64(3), 954-? -
Future Therapy for Hepatitis B Virus: Role of Immunomodulators.
Pham, E. A., Perumpail, R. B., Fram, B. J., Glenn, J. S., Ahmed, A., & Gish, R. G. (2016). Future Therapy for Hepatitis B Virus: Role of Immunomodulators. Current Hepatology Reports, 15(4), 237–44. -
Profiling system-wide immune signaling in chronic viral infection and its response to viral clearance
Angel, C. J. L., Furman, D., Pham, E., Fram, B., Thai Nguyen, Ahmed, A., … Davis, M. M. (2016). Profiling system-wide immune signaling in chronic viral infection and its response to viral clearance. JOURNAL OF IMMUNOLOGY. AMER ASSOC IMMUNOLOGISTS. -
Differences in Hepatocellular Carcinoma Incidence and Survival Rates among Asian Mono-Ethnicities
Cholankeril, G., Perumpail, R. B., Hu, M., Pham, E. A., Kumari, R., Gish, R., … Ahmed, A. (2016). Differences in Hepatocellular Carcinoma Incidence and Survival Rates among Asian Mono-Ethnicities. HEPATOLOGY. WILEY. -
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPalpha expression.
Myers, L. M., Tal, M. C., Torrez Dulgeroff, L. B., Carmody, A. B., Messer, R. J., Gulati, G., … Hasenkrug, K. J. (2019). A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPalpha expression. Nature Communications, 10(1), 794. -
A New Standard of Care? Standard Dose Sofosbuvir in an HCV-Infected Liver Transplant Recipient Undergoing Hemodialysis.
Perumpail, R. B., Wong, R. J., Pham, E. A., Higgins, J. P., Daugherty, T. J., & Ahmed, A. (2016). A New Standard of Care? Standard Dose Sofosbuvir in an HCV-Infected Liver Transplant Recipient Undergoing Hemodialysis. Digestive Diseases and Sciences, 61(1), 39–41. -
Trends in Mortality From Extrahepatic Complications in Patients With Chronic Liver Disease, From 2007 Through 2017.
Kim, D., Adejumo, A. C., Yoo, E. R., Iqbal, U., Li, A. A., Pham, E. A., … Ahmed, A. (2019). Trends in Mortality From Extrahepatic Complications in Patients With Chronic Liver Disease, From 2007 Through 2017. Gastroenterology. -
PI4KIIIß is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma.
Tan, X., Banerjee, P., Pham, E. A., Rutaganira, F. U., Basu, K., Bota-Rabassedas, N., … Kurie, J. M. (2020). PI4KIIIß is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Science Translational Medicine, 12(527). -
Fecal Microbiota Transplantation for Chronic Liver Diseases: Current Understanding and Future Direction.
Lechner, S., Yee, M., Limketkai, B. N., & Pham, E. A. (2020). Fecal Microbiota Transplantation for Chronic Liver Diseases: Current Understanding and Future Direction. Digestive Diseases and Sciences. -
High Prevalence of Concurrent Gastrointestinal Manifestations in Patients with SARS-CoV-2: Early Experience from California.
Cholankeril, G., Podboy, A., Aivaliotis, V. I., Tarlow, B., Pham, E. A., Spencer, S., … Ahmed, A. (2020). High Prevalence of Concurrent Gastrointestinal Manifestations in Patients with SARS-CoV-2: Early Experience from California. Gastroenterology. -
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look.
Rangan, R., Zheludev, I. N., & Das, R. (2020). RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look. RNA (New York, N.Y.). -
Association of Digestive Symptoms and Hospitalization in Patients With SARS-CoV-2 Infection.
Cholankeril, G., Podboy, A., Aivaliotis, V. I., Pham, E. A., Spencer, S. P., Kim, D., & Ahmed, A. (2020). Association of Digestive Symptoms and Hospitalization in Patients With SARS-CoV-2 Infection. The American Journal of Gastroenterology, 115(7), 1129–32. -
Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination.
Lopez Angel, C. J., Pham, E. A., Du, H., Vallania, F., Fram, B. J., Perez, K., … Furman, D. (2021). Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination. Proceedings of the National Academy of Sciences of the United States of America, 118(14). -
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome.
Zhang, K., Zheludev, I. N., Hagey, R. J., Haslecker, R., Hou, Y. J., Kretsch, R., … Das, R. (2021). Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome. Nature Structural & Molecular Biology. -
Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.
Hagey, R. J., Elazar, M., Pham, E. A., Tian, S., Ben-Avi, L., Bernardin-Souibgui, C., … Glenn, J. S. (2022). Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2. Nature Medicine.
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STRUCTURAL INSIGHTS INTO THE MECHANISM OF MICRORNA-MODULATED HCV TRANSLATION
Practice Locations
SHC- Gastro (450 Broadway) Redwood City, CA
Redwood City, CAImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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