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Sidhartha Sinha
Gastroenterologist, Inflammatory bowel disease specialist
Assistant Professor of Medicine (Gastroenterology and Hepatology) at the Stanford University Medical Center
Bio:
As a practicing gastroenterologist and researcher specializing in inflammatory bowel disease (IBD), a disease without medical cure and whose pathogenesis is incompletely understood, I am keenly aware of the resultant limitations and risks of existing IBD therapies. It is precisely this need—the need to offer patients improved treatment options by better understanding the underlying causes of IBD and its impact on patients—that motivates me and is a focus of my research. With a unique background with formal training in Biodesign (medical technology assessment and development) and postdoctoral training in translational immunology, I am particularly interested in developing and applying novel solutions to alleviate intestinal inflammatory conditions.
There are two primary and overlapping emphases of my research, both of which are driven and united by needs-based innovation and translational potential:
(1) Understanding the microenvironment of the inflamed versus normal gut in order to identify better therapeutic targets for people with immune-¬mediated GI disorders. Here, our investigations include understanding the influence and interactions of pharmacologic and dietary interventions on gut microbiome/metabolomic changes and the host immune response. In the context of providing patients with new understanding and solutions for their disease, I have led and advised on the design of both pilot and large clinical trials (including new FDA approved therapies) for anti-inflammatory therapies;
(2) Applying novel approaches and technologies (including natural language processing, computer vision, and reinforcement learning) to identify and address unmet clinical needs. In this area we have ongoing and published efforts in my lab to validate and develop solutions to pressing clinical needs. We have developed/led new drug delivery technologies with a multidisciplinary team that have shown strong potential in ongoing human IBD clinical trials. My lab has utilized both supervised and unsupervised approaches to analyze social media discourse and unstructured data sets for identifying patient needs that are rarely addressed in clinical settings. We have gained insights into patient perceptions around preventative health interventions, such as health screening and diet, including the dearth of evidence-based dietary recommendations to treat IBD (despite strong patient desire for solutions in this domain).
There are two primary and overlapping emphases of my research, both of which are driven and united by needs-based innovation and translational potential:
(1) Understanding the microenvironment of the inflamed versus normal gut in order to identify better therapeutic targets for people with immune-¬mediated GI disorders. Here, our investigations include understanding the influence and interactions of pharmacologic and dietary interventions on gut microbiome/metabolomic changes and the host immune response. In the context of providing patients with new understanding and solutions for their disease, I have led and advised on the design of both pilot and large clinical trials (including new FDA approved therapies) for anti-inflammatory therapies;
(2) Applying novel approaches and technologies (including natural language processing, computer vision, and reinforcement learning) to identify and address unmet clinical needs. In this area we have ongoing and published efforts in my lab to validate and develop solutions to pressing clinical needs. We have developed/led new drug delivery technologies with a multidisciplinary team that have shown strong potential in ongoing human IBD clinical trials. My lab has utilized both supervised and unsupervised approaches to analyze social media discourse and unstructured data sets for identifying patient needs that are rarely addressed in clinical settings. We have gained insights into patient perceptions around preventative health interventions, such as health screening and diet, including the dearth of evidence-based dietary recommendations to treat IBD (despite strong patient desire for solutions in this domain).
- 420 Broadway Street
- Pavilion D, 2nd Floor
- Redwood City , CA 94063
- Phone: 650-736-5555
- 420 Broadway Street
- Pavilion D, 2nd Floor
- Redwood City , CA 94063
- Phone: 650-736-5555
- 420 Broadway Street, Pavilion D, 2nd Floor
- Redwood City , CA 94063
- Phone: 650-736-5555
Practice Areas
- Capsule endoscopy
- Colitis
- Colonoscopy
- Colonoscopy
- Colorectal Cancer Screening
- Crohn's Disease
- Esophagogastroduodenoscopy (EGD)
- General Gastroenterology
- General GI Consultation
- Inflammatory Bowel Disease
- Other endoscopic procedures
- Ulcerative Colitis
- Upper GI endoscopy
Professional Education
- Board Certification: American Board of Internal Medicine, Gastroenterology (2014)
- Board Certification: American Board of Internal Medicine, Internal Medicine (2010)
- Fellowship: Stanford Hospital and Clinics (2014) CA
- Fellowship, Mayo Clinic, Rochester, MN (Crohn's & Colitis Foundation Visiting IBD Fellow Program), Inflammatory Bowel Disease (2013)
- Fellowship: Stanford Biodesign Program (2011) CA
- Residency: Stanford University School of Medicine (2010) CA
- Medical Education: University of California San Francisco (2007) CA
- BA, Harvard University (1997)
Administrative Appointments
- Director of Digital Health and Innovation, Division of Gastroenterology & Hepatology Stanford University School of Medicine (2019 - Present)
Publications
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Protecting health: thinking small
Sinha, S. R., & Batniji, R. (2010). Protecting health: thinking small. BULLETIN OF THE WORLD HEALTH ORGANIZATION, 88(9), 713–15. -
Health Technologies and Innovation in the Global Health Arena
Sinha, S. R., & Barry, M. (2011). Health Technologies and Innovation in the Global Health Arena. NEW ENGLAND JOURNAL OF MEDICINE, 365(9), 779–82. -
Enhanced imaging technologies in detecting dysplasia in IBD: narrowing or widening our options?
Sinha, S. R., & Shah, S. B. (2012). Enhanced imaging technologies in detecting dysplasia in IBD: narrowing or widening our options? Gastroenterology, 143(4), 1108–10. -
Shaping National Health Financing Systems: How Can Micro-banking Contribute?
Shaping National Health Financing Systems: How Can Micro-banking Contribute? (2009). World Health Organization Technical Brief, (2).
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Severe Iron Deficiency: Rare Etiology, Easy Treatment.
Sinha, S. R., Triadafilopoulos, G., & Shah, N. (2013). Severe Iron Deficiency: Rare Etiology, Easy Treatment. Digestive Diseases and Sciences, (Sep (epub).
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Effect of intra-tonsillar injection of Steroids on the palatine tonsils of rabbits.
Cho, D.-Y., & Sinha, S. R. (2013). Effect of intra-tonsillar injection of Steroids on the palatine tonsils of rabbits. Laryngoscope, (Sep (epub).
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Ethnic Disparities in the Association of Body Mass Index with the Risk of Hypertension and Diabetes
Wong, R. J., Chou, C., Sinha, S. R., Kamal, A., & Ahmed, A. (2014). Ethnic Disparities in the Association of Body Mass Index with the Risk of Hypertension and Diabetes. JOURNAL OF COMMUNITY HEALTH, 39(3), 437–45.
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Severe Iron Deficiency: Rare Etiology, Easy Treatment
Sinha, S. R., Triadafilopoulos, G., & Shah, N. (2014). Severe Iron Deficiency: Rare Etiology, Easy Treatment. DIGESTIVE DISEASES AND SCIENCES, 59(3), 538–542.
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Effect of Intratonsillar Injection of Steroids on the Palatine Tonsils of Rabbits
Cho, D.-Y., Sinha, S. R., Gardner, J. M., Schaller, M. P., Pamnani, R. D., Felt, S. A., … Messner, A. H. (2014). Effect of Intratonsillar Injection of Steroids on the Palatine Tonsils of Rabbits. LARYNGOSCOPE, 124(12), 2811–17.
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Strategies for last mile implementation of global health technologies.
Chao, T. E., Lo, N. C., Mody, G. N., & Sinha, S. R. (2014). Strategies for last mile implementation of global health technologies. The Lancet. Global Health, 2(9), e497–8.
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A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies.
Sinha, S. R., Nguyen, L. P., Inayathullah, M., Malkovskiy, A., Habte, F., Rajadas, J., & Habtezion, A. (2015). A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies. Gastroenterology, 149(1), 52–55 e2.
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Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits.
Cho, D.-Y., Sinha, S. R., Gardner, J. M., Schaller, M. P., Pamnani, R. D., Felt, S. A., … Messner, A. H. (2014). Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits. Laryngoscope, 124(12), 2811–17.
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Use of Tumor Necrosis Factor Alpha Inhibitors for Inflammatory Bowel Disease Patients with Concurrent Heart Failure.
Jiang, Y., Lin, O., & Sinha, S. R. (2017). Use of Tumor Necrosis Factor Alpha Inhibitors for Inflammatory Bowel Disease Patients with Concurrent Heart Failure. Digestive Diseases and Sciences, 62(6), 1597–1606.
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Using Social Media to Characterize Public Sentiment Toward Medical Interventions Commonly Used for Cancer Screening: An Observational Study.
Metwally, O., Blumberg, S., Ladabaum, U., & Sinha, S. R. (2017). Using Social Media to Characterize Public Sentiment Toward Medical Interventions Commonly Used for Cancer Screening: An Observational Study. Journal of Medical Internet Research, 19(6).
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Using Social Media to Characterize Public Sentiment Toward Medical Interventions Commonly Used for Cancer Screening: An Observational Study.
Metwally, O., Blumberg, S., Ladabaum, U., & Sinha, S. R. (2017). Using Social Media to Characterize Public Sentiment Toward Medical Interventions Commonly Used for Cancer Screening: An Observational Study. Journal of Medical Internet Research, 19(6).
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Use of Tumor Necrosis Factor Alpha Inhibitors for Inflammatory Bowel Disease Patients with Concurrent Heart Failure.
Jiang, Y., Lin, O., & Sinha, S. R. (2017). Use of Tumor Necrosis Factor Alpha Inhibitors for Inflammatory Bowel Disease Patients with Concurrent Heart Failure. Digestive Diseases and Sciences, 62(6), 1597–1606.
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Age-Related Changes inGut Microbiota AlterPhenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility.
Becker, L., Spear, E. T., Sinha, S. R., Haileselassie, Y., & Habtezion, A. (2019). Age-Related Changes inGut Microbiota AlterPhenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility. Cellular and Molecular Gastroenterology and Hepatology, 7(1), 243.
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Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases.
Rubin, S. J., Bai, L., Haileselassie, Y., Garay, G., Yun, C., Becker, L., … Habtezion, A. (2019). Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases. Nature Communications, 10(1), 2686.
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The high resource impact of reformatting requirements for scientific papers.
Jiang, Y., Lerrigo, R., Ullah, A., Alagappan, M., Asch, S. M., Goodman, S. N., & Sinha, S. R. (2019). The high resource impact of reformatting requirements for scientific papers. PloS One, 14(10), e0223976.
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Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
Sinha, S. R., Haileselassie, Y., Nguyen, L. P., Tropini, C., Wang, M., Becker, L. S., … Habtezion, A. (2020). Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Cell Host & Microbe.
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Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases.
Jadhav, P., Jiang, Y., Jarr, K., Layton, C., Ashouri, J. F., & Sinha, S. R. (2020). Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases. Nutrients, 12(7).
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Association of Anti-TNF Therapy With Increased Risk of Acute Cholangitis in Patients With Primary Sclerosing Cholangitis.
Kulkarni, C., Murag, S., Cholankeril, G., Fardeen, T., Mannalithara, A., Lerrigo, R., … Sinha, S. R. (2020). Association of Anti-TNF Therapy With Increased Risk of Acute Cholangitis in Patients With Primary Sclerosing Cholangitis. Inflammatory Bowel Diseases.
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Reply to Letter to the Editor: What is the incidence of COVID-19 in patients with IBD in western countries?
Gubatan, J., Sinha, S. R., & Habtezion, A. (2021). Reply to Letter to the Editor: What is the incidence of COVID-19 in patients with IBD in western countries? Gastroenterology.
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Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases.
Jiang, Y., Jarr, K., Layton, C., Gardner, C. D., Ashouri, J. F., Abreu, M. T., & Sinha, S. R. (2021). Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases. Nutrients, 13(3).
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Patient Comments
Patients comments are gathered from our Patient Satisfaction Survey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
SHC Patient, Jan 2020
Thank you doctors and staffs.
SHC Patient, Jan 2020
Dr. Sinha is always available to answer questions; I always feel if I have a problem he will work with me to find a solution.
SHC Patient, Jul 2019
Very excellent -
SHC Patient, May 2019
Dr. Sidhartha Ranjit was very impressive - confident & competent! Best of all he was not one time looking at a screen of ANY type!
SHC Patient, Mar 2019
Dr. Sinha was very attentive. He took time to answer our questions. He showed patience, care and respect.
SHC Patient, Mar 2019
Since I've been under treatment for a while, Dr. Sinha went through the visit/check-up quickly. I would have appreciated going over details of my condition regardless of the fact that it is routine.
SHC Patient, Dec 2018
The best.
SHC Patient, Oct 2018
Dr. Sinha was absolutely great, provide terrific information and took the time to understand my problem, and developed a positive path forward!
SHC Patient, Oct 2018
Always very clean & shows concern & expertise on how his plan & rec. fit into the total healthcare plan.
SHC Patient, Aug 2018
Appreciated the time doctor spend with me in office reviewing my case.
SHC Patient, Nov 2017
Dr. Sidhartha is a excellent doctor and provider.
SHC Patient, Aug 2017
More structure for future care is needed.
SHC Patient, Jul 2017
This was the best part. My doctor was great. But it's hard to reach him now that I'm out of my appointment.
SHC Patient, Jun 2017
Excellent care provider.
SHC Patient, Mar 2017
Dr. Sinha is wonderful very caring & thorough.
SHC Patient, Sep 2016
I love him! He is truly concerned about the direction my care needs to go. Trying an experiment now.
SHC Patient, Feb 2016
Not only Dr. Sinha but an intern doctor who interviewed me was informative and helpful with new information, to me, to help manage my condition "FODMAP" for a food guide.
SHC Patient, Mar 2015
Dr. Sinha found answers we have about my husband's health.
SHC Patient, Dec 2014
Dr. Sinha is one of the most knowledgeable & courteous doctors I've ever seen.
SHC Patient, Dec 2014
I was very happy with Dr. Sinha. He made me feel totally comfortable & at ease, and he was very easy to talk to.
SHC Patient, Oct 2014
All info fax was not in chart both times.
SHC Patient, Sep 2014
Both my husband and I were very impressed with Dr. Sinhas' thoroughness and compassion with my condition.
SHC Patient, Sep 2014
He did not give any written summary of appointment - Leaving me... only.
SHC Patient, Jan 2020
Thank you doctors and staffs.
SHC Patient, Jan 2020
Dr. Sinha is always available to answer questions; I always feel if I have a problem he will work with me to find a solution.
SHC Patient, Jul 2019
Very excellent -
SHC Patient, May 2019
Dr. Sidhartha Ranjit was very impressive - confident & competent! Best of all he was not one time looking at a screen of ANY type!
SHC Patient, Mar 2019
Dr. Sinha was very attentive. He took time to answer our questions. He showed patience, care and respect.
SHC Patient, Mar 2019
Since I've been under treatment for a while, Dr. Sinha went through the visit/check-up quickly. I would have appreciated going over details of my condition regardless of the fact that it is routine.
SHC Patient, Dec 2018
The best.
SHC Patient, Oct 2018
Dr. Sinha was absolutely great, provide terrific information and took the time to understand my problem, and developed a positive path forward!
SHC Patient, Oct 2018
Always very clean & shows concern & expertise on how his plan & rec. fit into the total healthcare plan.
SHC Patient, Aug 2018
Appreciated the time doctor spend with me in office reviewing my case.
SHC Patient, Nov 2017
Dr. Sidhartha is a excellent doctor and provider.
SHC Patient, Aug 2017
More structure for future care is needed.
View All 23 Patient Comments »