Biography
As a neuroscientist, he is interested in preclinical models of mental illness and investigating new therapies for mood disorders and addiction. In particular, he is interested in defining new cell types and evolutionary conserved circuits in emotional processing centers of the brain with the hope of finding new entry points for novel therapeutics. Currently under the mentorship Dr Robert Malenka, he is using optogenetic, chemogenetic, neuroimaging and behavioral approaches in mouse models of addiction to uncover vulnerable brain circuitry in opioid use disorder. Under the mentorship of Dr Alan Schatzberg he is investigating the efficacy of buprenorphine augmentation to IV ketamine infusion at reducing suicidality in treatment resistant depression.
Prior to training in psychiatry at Stanford’s research residency track Jason received his bachelor’s degree in biology and philosophy from Union College. He spent three years as a Post-Baccalaureate IRTA fellow at the National Institute of Neurological Disorders and Stroke investigating and developing MRI reportable contrast agents to map neuronal connectivity. Following this he entered the Medical Scientist Training Program (MD/PhD) at the State University of NY Stony Brook University. There he completed a doctoral dissertation in neuroscience under the mentorship Dr. Josh Huang at Cold Spring Harbor Laboratory. His thesis work employed mouse genetic dissections of excitatory and inhibitory cortical circuits with a focus on the circuitry of chandelier inhibitory interneurons in prefrontal cortex.
In addition to his research and clinical work, Jason is passionate about teaching, mentorship, and resident clinical supervision. He joined a working group early in his clinical residency to restructure trainee’s neuroscience education. He teaches introductory lectures in the neuroscience of addiction, PTSD, psychosis, and mood disorders. He also leads resident group supervision in their introductory psychodynamic psychotherapy clinical experience. He supervises medical students, residents, and clinical fellows in Neuropsychiatry clinic. Finally, to contribute to the Stanford clinical community, he leads a support group for Internal Medicine interns and residents.
Professional Summary
Education & Certifications
- Board Certification: American Board of Psychiatry and Neurology, Psychiatry (2021)
- Residency: Stanford University Adult Psychiatry Residency (2021) CA
- Medical Education: State University of New York at Stony Brook Office of the Registrar (2017) NY
Honors & Awards
- Alpha Omega Alpha Medical Honor Society, Alpha Omega Alpha (2021)
- Career Development Institute for Psychiatry, Stanford University and the University of Pittsburgh (2022)
- Marnell Award for Psychotherapy, Stanford Department of Psychiatry (2021)
- NARSAD Young Investigator Award, Brain & Behavior Research Foundation (2023-2025)
- NIH K08 Mentored Clinical Scientist Research Career Development Award, National Institute on Drug Abuse (NIDA) (2023-2028)
- Psychotherapy Fellowship, American Psychoanalytic Association (2020-2021)
- T32 Postdoctoral Fellowship, Stanford University, NIMH (2020-2022)
Publications
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Targeting cells with single vectors using multiple-feature Boolean logic.
Fenno, L. E., Mattis, J., Ramakrishnan, C., Hyun, M., Lee, S. Y., He, M., … Deisseroth, K. (2014). Targeting cells with single vectors using multiple-feature Boolean logic. Nature Methods, 11(7), 763–72. -
Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.
Lu, J., Tucciarone, J., Padilla-Coreano, N., He, M., Gordon, J. A., & Huang, Z. J. (2017). Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. Nature Neuroscience. -
A basal ganglia circuit for evaluating action outcomes
Stephenson-Jones, M., Yu, K., Ahrens, S., Tucciarone, J. M., van Huijstee, A. N., Mejia, L. A., … Li, B. (2016). A basal ganglia circuit for evaluating action outcomes. NATURE, 539(7628), 289-? -
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
He, M., Tucciarone, J., Lee, S., Nigro, M. J., Kim, Y., Levine, J. M., … Huang, Z. J. (2016). Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. NEURON, 91(6), 1228–43. -
Cooperative Subnetworks of Molecularly Similar Interneurons in Mouse Neocortex
Karnani, M. M., Jackson, J., Ayzenshtat, I., Tucciarone, J., Manoocheri, K., Snider, W. G., & Yuste, R. (2016). Cooperative Subnetworks of Molecularly Similar Interneurons in Mouse Neocortex. NEURON, 90(1), 86–100. -
The Mediodorsal Thalamus Drives Feedforward Inhibition in the Anterior Cingulate Cortex via Parvalbumin Interneurons
Delevich, K., Tucciarone, J., Huang, Z. J., & Li, B. (2015). The Mediodorsal Thalamus Drives Feedforward Inhibition in the Anterior Cingulate Cortex via Parvalbumin Interneurons. JOURNAL OF NEUROSCIENCE, 35(14), 5743–53. -
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., … Li, B. (2015). The paraventricular thalamus controls a central amygdala fear circuit. NATURE, 519(7544), 455-? -
Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex
Lu, J., Tucciarone, J., Lin, Y., & Huang, Z. J. (2014). Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(47), 16895–900. -
A Cortical Circuit for Gain Control by Behavioral State
Fu, Y., Tucciarone, J. M., Espinosa, J. S., Sheng, N., Darcy, D. P., NiColl, R. A., … Stryker, M. P. (2014). A Cortical Circuit for Gain Control by Behavioral State. CELL, 156(6), 1139–52. -
Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI
Tucciarone, J., Chuang, K.-H., Dodd, S. J., Silva, A., Pelled, G., & Koretsky, A. P. (2009). Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. NEUROIMAGE, 44(3), 923–31. -
Detection of cortical laminar architecture using manganese-enhanced MRI
Silva, A. C., Lee, J. H., Wu, C. W. H., Tucciarone, J., Pelled, G., Aoki, L., & Koretsky, A. P. (2008). Detection of cortical laminar architecture using manganese-enhanced MRI. JOURNAL OF NEUROSCIENCE METHODS, 167(2), 246–57. -
Evaluation of the appropriate use of a CIWA-Ar alcohol withdrawal protocol in the general hospital setting.
Eloma, A. S., Tucciarone, J. M., Hayes, E. M., & Bronson, B. D. (2017). Evaluation of the appropriate use of a CIWA-Ar alcohol withdrawal protocol in the general hospital setting. The American Journal of Drug and Alcohol Abuse, 1–8. -
Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.
Wang, X., Tucciarone, J., Jiang, S., Yin, F., Wang, B.-S. S., Wang, D., … Huang, Z. J. (2019). Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells. Cell Reports, 26(11), 3145–3159.e5. -
A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement
Xiao, X., Deng, H., Furlan, A., Yang, T., Zhang, X., Hwang, G.-R., … Li, B. (2020). A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. CELL, 183(1), 211-+. -
Genetic dissection of the glutamatergic neuron system in cerebral cortex.
Matho, K. S., Huilgol, D., Galbavy, W., He, M., Kim, G., An, X., … Huang, Z. J. (2021). Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature, 598(7879), 182–187. -
Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal.
Pomrenze, M. B., Cardozo Pinto, D. F., Neumann, P. A., Llorach, P., Tucciarone, J. M., Morishita, W., … Malenka, R. C. (2022). Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron. -
Collaboratively Designed Neuroscience Curriculum for Psychiatry Residents.
Tucciarone, J., Willard, D., Kleinman, R., Bentzley, B. S., Hayward, C., & Raj, K. S. (2023). Collaboratively Designed Neuroscience Curriculum for Psychiatry Residents. Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. -
Striatal dopamine integrates cost, benefit, and motivation.
Eshel, N., Touponse, G. C., Wang, A. R., Osterman, A. K., Shank, A. N., Groome, A. M., … Malenka, R. C. (2023). Striatal dopamine integrates cost, benefit, and motivation. Neuron. -
Gating of Opioid Withdrawal Aversion by a Unique Class of Neurons in the Nucleus Accumbens
Tucciarone, J., Pomrenze, M., Baek, J., Zhang, Z., Touponse, G., Shank, A., … Malenka, R. (2023). Gating of Opioid Withdrawal Aversion by a Unique Class of Neurons in the Nucleus Accumbens. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE.
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