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The risk for breast cancer is increased with Li-Fraumeni syndrome (LFS), a genetic autosomal dominant cancer syndrome. A diagnosis of LFS is made when all of the following characteristics are present in a family:
Sarcoma <45 years of age and
A first degree relative with cancer <45 years of age and
A first or second degree relative with cancer <45 years of age or sarcoma at any age
Li-Fraumeni Syndrome A rare, inherited disorder, Li-Fraumeni syndrome is a genetic mutation of CHEK2 and TP53, tumor suppressor genes, greatly increasing the risk of cancer in children. Li-Fraumeni Syndrome