GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)

Trial ID or NCT#

NCT04196413

Status

recruiting iconRECRUITING

Purpose

The primary purpose of this study is to test whether CAR T cells targeting GD2 (GD2CART) can be successfully made and safely given to children and adults with H3K27M-mutant diffuse midline glioma (DMG). Eligible subjects may have DMG arising in the pons (called difuse intrinisic pontine glioma, DIPG), the spinal cord, or other areas of the brain such as a thalamus

Official Title

Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for H3K27M-mutant Diffuse Midline Glioma (DMG)

Eligibility Criteria

Ages Eligible for Study: 2 Years to 60 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Exclusion Criteria:
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Investigator(s)

Michelle Monje
Paul Graham Fisher, MD
Paul Graham Fisher, MD
Neuro-oncologist, Pediatric neurologist
Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
Sonia Partap
Gordon Li, MD
Gordon Li, MD
Neurosurgeon
Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Otolaryngology - Head & Neck Surgery (OHNS)
Kara Davis
Catherine Aftandilian
Susan Hiniker
Susan Hiniker
Radiation oncologist
Associate Professor of Radiation Oncology (Radiation Therapy)
Crystal Mackall
Laura Prolo
Associate Professor of Neurosurgery and, by courtesy, of Neurology (Pediatric Neurology)
Saurabh Dahiya, MD, FACP
Saurabh Dahiya, MD, FACP
Hematologist-Oncologist
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Lindsey Rasmussen
Timothy Thomas Cornell
Sneha Ramakrishna
Tanja A. Gruber
Michael Lim, M.D.
Michael Lim, M.D.
Neurosurgeon, Neurosurgeon
Stanford Medicine Endowed Chair of the Department of Neurosurgery, Professor of Neurosurgery and, by courtesy, of Radiation Oncology, of Medicine, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology and Neurological Sciences
Raya Saab
Claire Johns
Katherine Jane Ryan

Contact us to find out if this trial is right for you.

Contact

GD2CART@stanfordchildrens.org
650-497-7533

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View on ClinicalTrials.gov