GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)
Trial ID or NCT#
NCT04196413
Status
RECRUITING
Purpose
The primary purpose of this study is to test whether CAR T cells targeting GD2 (GD2CART) can be successfully made and safely given to children and adults with H3K27M-mutant diffuse midline glioma (DMG). Eligible subjects may have DMG arising in the pons (called difuse intrinisic pontine glioma, DIPG), the spinal cord, or other areas of the brain such as a thalamus
Official Title
Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for H3K27M-mutant Diffuse Midline Glioma (DMG)
Eligibility Criteria
Ages Eligible for Study: 2 Years to 60 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Exclusion Criteria:
Investigator(s)
Michelle Monje
Sonia Partap
Sneha Ramakrishna
Crystal Mackall
Paul Graham Fisher, MD
Neuro-oncologist,
Pediatric neurologist
Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
Timothy Thomas Cornell
Lindsey Rasmussen
Kara Davis
Laura Prolo
Associate Professor of Neurosurgery and, by courtesy, of Neurology (Pediatric Neurology)
Katherine Jane Ryan
Claire Johns
Michael Lim, M.D.
Neurosurgeon,
Neurosurgeon
Stanford Medicine Endowed Chair of the Department of Neurosurgery, Professor of Neurosurgery and, by courtesy, of Radiation Oncology, of Medicine, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology and Neurological Sciences
Saurabh Dahiya, MD, FACP
Hematologist-Oncologist
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Tanja A. Gruber
Raya Saab
Catherine Aftandilian
Jay Michael S. Balagtas
Norman J. Lacayo, MD
Gordon Li, MD
Neurosurgeon
Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Otolaryngology - Head & Neck Surgery (OHNS)
Kun Wei Song
Clinical Instructor, Pediatric Neurology
Contact us to find out if this trial is right for you.
Contact
GD2CART@stanfordchildrens.org
650-497-7533
View on ClinicalTrials.gov
