Lawrence Leung

Hematologist

Medical oncologist, Leukemia specialist

Hematology Program

  • 875 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
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Professional Education

Fellowship: New York Hospital (1981) NY

Internship: New York Hospital (1976) NY

Medical Education: Columbia University (1975) NY

Residency: New York Hospital (1978) NY

Board Certification: Hematology, American Board of Internal Medicine (1980)

Board Certification: Internal Medicine, American Board of Internal Medicine (1978)

Board Certification: Medical Oncology, American Board of Internal Medicine (1981)

Administrative Appointments

Chief of Staff, VA Palo Alto Health Care System, 2006

Senior Associate Dean for Veterans Affairs, School of Medicine, 2006

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding.
Sheikh, A. Y., Hill, C. C., Goodnough, L. T., Leung, L. L., & Fischbein, M. P. (2014). Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding. Transfusion, 54(2), 300-305.

Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Khan, M. A., Maasch, C., Vater, A., Klussmann, S., Morser, J., & Nicolls, M. R. (2013). Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proceedings of the National Academy of Sciences of the United States of America, 110(15), 6061-6066.

Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage
Yamaguchi, Y., Shao, Z., Sharif, S., Du, X.-Y., Myles, T., & Leung, L. Lk. (2013). Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(5), 3097-3111.

Microfluidic impedance cytometer for platelet analysis
Evander, M., Ricco, A. J., Morser, J., Kovacs, G. Ta., Leung, L. Lk., & Giovangrandi, L. (2013). Microfluidic impedance cytometer for platelet analysis. LAB ON A CHIP, 13(4), 722-729.

Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma
Zhao, L., Yamaguchi, Y., Sharif, S., Du, X.-Y., Song, J. J., & Leung, L. Lk. (2011). Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(45), 39520-39527.

Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma
Yamaguchi, Y., Du, X.-Y., Zhao, L., Morser, J., & Leung, L. Lk. (2011). Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(45), 39510-39519.

Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
Song, J. J., Hwang, Iy., Cho, K. H., Garcia, M. A., Kim, A. J., & Robinson, W. H. (2011). Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3517-3527.

Enhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B-Deficient Mice
Schultz, G., Tedesco, M. M., Sho, E., Nishimura, T., Sharif, S., & Leung, L. Lk. (2010). Enhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B-Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(7), 1363-1370.

What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?
Morser, J., Gabazza, E. C., Myles, T., & Leung, L. Lk. (2010). What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8(5), 868-876.

Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation
Wang, C.-H., Su, P.-T., Du, X.-Y., Kuo, M.-W., Lin, C.-Y., & Chuan, Y.-J. (2010). Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation. JOURNAL OF CELLULAR PHYSIOLOGY, 222(3), 685-694.

Heparin-induced thrombosis without thrombocytopenia
Tibayan, F. A., Leung, L. L., Burdon, T. A., & Fann, J. I. (2010). Heparin-induced thrombosis without thrombocytopenia. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139(2), E6-E7.

Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis
Sharif, S. A., Du, X., Myles, T., Song, J. J., Price, E., & Leung, L. Lk. (2009). Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 60(10), 2902-2912.

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
Du, X.-Y., Zabel, B. A., Myles, T., Allen, S. J., Handel, T. M., & Leung, L. L. (2009). Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(2), 751-758.

Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI)
Leung, L. Lk., Myles, T., Nishimura, T., Song, J. J., & Robinson, W. H. (2008). Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI). MOLECULAR IMMUNOLOGY, 45(16), 4080-4083.

Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites
Myles, T., & Leung, L. Lk. (2008). Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(26), 17789-17796.

Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin
Fortenberry, Y. M., Whinna, H. C., Cooper, S. T., Myles, T., Leung, L. Lk., & Church, F. C. (2007). Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 5(7), 1486-1492.

Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo
Nishimura, T., Myles, T., Piliposky, A. M., Kao, P. N., Berry, G. J., & Leung, L. Lk. (2007). Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. BLOOD, 109(5), 1992-1997.

Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells
Zhang, W., Chuang, Y.-J., Jin, T., Swanson, R., Xiong, Y., & Olson, S. T. (2006). Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells. CANCER RESEARCH, 66(10), 5047-5055.

Perioperative evaluation of bleeding diathesis.
Leung, L. Lk. (2006). Perioperative evaluation of bleeding diathesis. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 457-461.

Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery
Carter, W. J., Myles, T., Gibbs, C. S., Leung, L. L., & Huntington, J. A. (2004). Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(25), 26387-26394.

Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms
Ishida, T., Zheng, Z., Dichek, H. L., Wang, H. J., Moreno, I., & Quertermous, T. (2004). Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms. GENOMICS, 83(1), 24-33.

Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation
Myles, T., Nishimura, T., Yun, T. H., Nagashima, M., MORSER, J., & Leung, L. Lk. (2003). Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(51), 51059-51067.

Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively (Retracted Article. See vol 282, pg 29067, 2007)
Yun, T. H., Baglia, F. A., Myles, T., Navaneetham, D., Lopez, J. A., & Leung, L. Lk. (2003). Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively (Retracted Article. See vol 282, pg 29067, 2007). JOURNAL OF BIOLOGICAL CHEMISTRY, 278(48), 48112-48119.

Structural requirements for the activation of human factor VIII by thrombin
Myles, T., Yun, T. H., & Leung, L. Lk. (2002). Structural requirements for the activation of human factor VIII by thrombin. BLOOD, 100(8), 2820-2826.

Identification of critical residues on thrombin mediating its interaction with fibrin
HALL, S. W., Gibbs, C. S., & Leung, L. Lk. (2001). Identification of critical residues on thrombin mediating its interaction with fibrin. THROMBOSIS AND HAEMOSTASIS, 86(6), 1466-1474.

An extensive interaction interface between thrombin and factor V is required for factor V activation
Myles, T., Yun, T. H., HALL, S. W., & Leung, L. Lk. (2001). An extensive interaction interface between thrombin and factor V is required for factor V activation. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(27), 25143-25149.

Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains
Hall, S. W., Nagashima, M., Zhao, L., MORSER, J., & Leung, L. Lk. (1999). Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(36), 25510-25516.

Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties
HALL, S. W., Gibbs, C. S., & Leung, L. Lk. (1997). Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties. CELLULAR AND MOLECULAR LIFE SCIENCES, 53(9), 731-736.

Modulation of thrombin's procoagulant and anticoagulant properties
Leung, L. Lk., & Gibbs, C. S. (1997). Modulation of thrombin's procoagulant and anticoagulant properties. THROMBOSIS AND HAEMOSTASIS, 78(1), 577-580.

SELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR THROMBIN USING IN-VITRO GENETICS
Tsiang, M., Gibbs, C. S., Griffin, L. C., Dunn, K. E., & Leung, L. Lk. (1995). SELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR THROMBIN USING IN-VITRO GENETICS. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(33), 19370-19376.

FUNCTIONAL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN
Tsiang, M., Jain, A. K., Dunn, K. E., Rojas, M. E., Leung, L. Lk., & Gibbs, C. S. (1995). FUNCTIONAL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(28), 16854-16863.

Conversion of thrombin into an anticoagulant by protein engineering
Leung LLK, Gibbs CS, Coutre SE, Tsiang M, Li WX, & Paborsky LR. (1995). Conversion of thrombin into an anticoagulant by protein engineering. Nature.