Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Hematology (1980)
- Residency: New York Presbyterian Cornell Campus Internal Medicine Residency (1978) NY
- Internship: New York Presbyterian Cornell Campus Internal Medicine Residency (1976) NY
- Fellowship: New York Presbyterian Cornell Campus Hematology Oncology Fellowship (1981) NY
- Medical Education: Columbia University Vagelos College of Physicians and Surgeons Registrar (1975) NY
- Board Certification: American Board of Internal Medicine, Internal Medicine (1978)
- Board Certification: American Board of Internal Medicine, Medical Oncology (1981)
Memberships
- Editor-in-Chief, Hematology, UpToDate (2008 - Present)
- Member, Association of American Physicians (2004 - Present)
- Member, American Society for Clinical Investigation (1987 - Present)
Administrative Appointments
- Chief of Staff, VA Palo Alto Health Care System (2006 - 2020)
- Senior Associate Dean for Veterans Affairs, School of Medicine (2006 - 2020)
Publications
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Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains
Hall, S. W., Nagashima, M., Zhao, L., MORSER, J., & Leung, L. L. K. (1999). Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(36), 25510–16. -
An extensive interaction interface between thrombin and factor V is required for factor V activation
Myles, T., Yun, T. H., HALL, S. W., & Leung, L. L. K. (2001). An extensive interaction interface between thrombin and factor V is required for factor V activation. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(27), 25143–49. -
Immunological consequences of topical bovine thrombin
Zehnder, J. L., & Leung, L. L. K. (2001). Immunological consequences of topical bovine thrombin. AMERICAN JOURNAL OF PATHOLOGY, 159(6), 2371–71. -
Identification of critical residues on thrombin mediating its interaction with fibrin
HALL, S. W., Gibbs, C. S., & Leung, L. L. K. (2001). Identification of critical residues on thrombin mediating its interaction with fibrin. THROMBOSIS AND HAEMOSTASIS, 86(6), 1466–74. -
Structural requirements for the activation of human factor VIII by thrombin
Myles, T., Yun, T. H., & Leung, L. L. K. (2002). Structural requirements for the activation of human factor VIII by thrombin. BLOOD, 100(8), 2820–26. -
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively (Retracted Article. See vol 282, pg 29067, 2007)
Yun, T. H., Baglia, F. A., Myles, T., Navaneetham, D., Lopez, J. A., Walsh, P. N., & Leung, L. L. K. (2003). Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively (Retracted Article. See vol 282, pg 29067, 2007). JOURNAL OF BIOLOGICAL CHEMISTRY, 278(48), 48112–19. -
Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation
Myles, T., Nishimura, T., Yun, T. H., Nagashima, M., MORSER, J., Patterson, A. J., … Leung, L. L. K. (2003). Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(51), 51059–67. -
Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms
Ishida, T., Zheng, Z., Dichek, H. L., Wang, H. J., Moreno, I., Yang, E., … Quertermous, T. (2004). Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms. GENOMICS, 83(1), 24–33. -
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery
Carter, W. J., Myles, T., Gibbs, C. S., Leung, L. L., & Huntington, J. A. (2004). Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(25), 26387–26394. -
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo
Nishimura, T., Myles, T., Piliposky, A. M., Kao, P. N., Berry, G. J., & Leung, L. L. K. (2007). Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. BLOOD, 109(5), 1992–97. -
Perioperative evaluation of bleeding diathesis.
Leung, L. L. K. (2006). Perioperative evaluation of bleeding diathesis. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 457–461. -
Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites
Myles, T., & Leung, L. L. K. (2008). Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(26), 17789–96. -
Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI)
Leung, L. L. K., Myles, T., Nishimura, T., Song, J. J., & Robinson, W. H. (2008). Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI). MOLECULAR IMMUNOLOGY, 45(16), 4080–83. -
Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
Du, X.-Y., Zabel, B. A., Myles, T., Allen, S. J., Handel, T. M., Lee, P. P., … Leung, L. L. (2009). Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(2), 751–58. -
Heparin-induced thrombosis without thrombocytopenia
Tibayan, F. A., Leung, L. L., Burdon, T. A., & Fann, J. I. (2010). Heparin-induced thrombosis without thrombocytopenia. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139(2), E6–E7. -
Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis
Sharif, S. A., Du, X., Myles, T., Song, J. J., Price, E., Lee, D. M., … Leung, L. L. K. (2009). Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 60(10), 2902–12. -
Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation
Wang, C.-H., Su, P.-T., Du, X.-Y., Kuo, M.-W., Lin, C.-Y., Yang, C.-C., … Chuan, Y.-J. (2010). Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation. JOURNAL OF CELLULAR PHYSIOLOGY, 222(3), 685–94. -
What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?
Morser, J., Gabazza, E. C., Myles, T., & Leung, L. L. K. (2010). What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse? JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8(5), 868–76. -
Enhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B-Deficient Mice
Schultz, G., Tedesco, M. M., Sho, E., Nishimura, T., Sharif, S., Du, X., … Leung, L. L. K. (2010). Enhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B-Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(7), 1363–70. -
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
Song, J. J., Hwang, I. Y., Cho, K. H., Garcia, M. A., Kim, A. J., Wang, T. H., … Robinson, W. H. (2011). Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3517–27. -
Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma
Zhao, L., Yamaguchi, Y., Sharif, S., Du, X.-Y., Song, J. J., Lee, D. M., … Leung, L. L. K. (2011). Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(45), 39520–27. -
Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma
Yamaguchi, Y., Du, X.-Y., Zhao, L., Morser, J., & Leung, L. L. K. (2011). Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(45), 39510–19. -
Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage
Yamaguchi, Y., Shao, Z., Sharif, S., Du, X.-Y., Myles, T., Merchant, M., … Leung, L. L. K. (2013). Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(5), 3097–3111. -
Microfluidic impedance cytometer for platelet analysis
Evander, M., Ricco, A. J., Morser, J., Kovacs, G. T. A., Leung, L. L. K., & Giovangrandi, L. (2013). Microfluidic impedance cytometer for platelet analysis. LAB ON A CHIP, 13(4), 722–729. -
Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Khan, M. A., Maasch, C., Vater, A., Klussmann, S., Morser, J., Leung, L. L., … Nicolls, M. R. (2013). Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proceedings of the National Academy of Sciences of the United States of America, 110(15), 6061–6066. -
Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding.
Sheikh, A. Y., Hill, C. C., Goodnough, L. T., Leung, L. L., & Fischbein, M. P. (2014). Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding. Transfusion, 54(2), 300–305. -
FUNCTIONAL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN
Tsiang, M., Jain, A. K., Dunn, K. E., Rojas, M. E., Leung, L. L. K., & Gibbs, C. S. (1995). FUNCTIONAL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(28), 16854–16863. -
SELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR THROMBIN USING IN-VITRO GENETICS
Tsiang, M., Gibbs, C. S., Griffin, L. C., Dunn, K. E., & Leung, L. L. K. (1995). SELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR THROMBIN USING IN-VITRO GENETICS. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(33), 19370–19376. -
PILOT-STUDY OF THE EFFICACY OF A THROMBIN INHIBITOR FOR USE DURING CARDIOPULMONARY BYPASS
DeAnda, A., Coutre, S. E., Moon, M. R., Vial, C. M., Griffin, L. C., Law, V. S., … Miller, D. C. (1994). PILOT-STUDY OF THE EFFICACY OF A THROMBIN INHIBITOR FOR USE DURING CARDIOPULMONARY BYPASS. ANNALS OF THORACIC SURGERY. NEW ORLEANS,LA,LA,LA,LA,LA,LA,LA: ELSEVIER SCIENCE INC. -
Modulation of thrombin's procoagulant and anticoagulant properties
Leung, L. L. K., & Gibbs, C. S. (1997). Modulation of thrombin's procoagulant and anticoagulant properties. THROMBOSIS AND HAEMOSTASIS, 78(1), 577–80. -
Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties
HALL, S. W., Gibbs, C. S., & Leung, L. L. K. (1997). Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties. CELLULAR AND MOLECULAR LIFE SCIENCES, 53(9), 731–36. -
Conversion of thrombin into an anticoagulant by protein engineering
Conversion of thrombin into an anticoagulant by protein engineering. (1995). Nature. -
Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin
Fortenberry, Y. M., Whinna, H. C., Cooper, S. T., Myles, T., Leung, L. L. K., & Church, F. C. (2007). Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 5(7), 1486–1492. -
Thrombin inhibition by a reactive center L444R mutant of heparin cofactor II
Fortenberry, Y. M., Mitchell, J. W., Myles, T., Leung, L. L. K., & Church, F. C. (2002). Thrombin inhibition by a reactive center L444R mutant of heparin cofactor II. FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL. -
Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAF1a) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis
Sharif, S., Du, X.-Y., Myles, T., Song, J. J., Price, E. A., Lee, D., … Leung, L. L. (2008). Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAF1a) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis. BLOOD. SAN FRANCISCO,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA: AMER SOC HEMATOLOGY. -
Quantitative transcript profiling and the identification of a novel vascular endothelial cell marker, placental endothelial protein-1, by serial analysis of gene expression.
Chuang, Y. J., Seo, K., Gray, J., Druzin, M., Kuo, C., & Leung, L. (2003). Quantitative transcript profiling and the identification of a novel vascular endothelial cell marker, placental endothelial protein-1, by serial analysis of gene expression. BLOOD. SAN DIEGO,CA,CA,CA,CA,CA: AMER SOC HEMATOLOGY. -
Dissociation of thrombin's protein C and TAFI activities by site-directed mutagenesis.
HALL, S. W., Nagashima, M., Zhao, L., MORSER, J., & Leung, L. L. K. (1998). Dissociation of thrombin's protein C and TAFI activities by site-directed mutagenesis. BLOOD. AMER SOC HEMATOLOGY. -
Prochemerin Is a New Substrate for Thrombin
Du, X., Myles, T., Morser, J., & Leung, L. L. (2009). Prochemerin Is a New Substrate for Thrombin. BLOOD, 114(22), 1391–91. -
Chemerin Bioactivity Is Regulated by Factor XIa: A Novel Interface Linking Between Coagulation, Hemostasis and Immunity
Yamaguchi, Y., Morser, J., & Leung, L. L. (2011). Chemerin Bioactivity Is Regulated by Factor XIa: A Novel Interface Linking Between Coagulation, Hemostasis and Immunity. BLOOD, 118(21), 981–82. -
Enhanced abdominal aortic aneurysm formation in procarboxypeptidase B-deficient mice
Tedesco, M. M., Sho, E., Nishimura, T., Sho, M., Dalman, R. L., & Leung, L. L. (2006). Enhanced abdominal aortic aneurysm formation in procarboxypeptidase B-deficient mice. CIRCULATION. CHICAGO,IL,IL: LIPPINCOTT WILLIAMS & WILKINS. -
Mechanism of interaction between the heavy chain of factor VIII and thrombin
Nogami, K., Zhou, Q., Wakabayashi, H., Myles, T., Leung, L. L., & Fay, P. J. (2004). Mechanism of interaction between the heavy chain of factor VIII and thrombin. BLOOD. SAN DIEGO,CA,CA: AMER SOC HEMATOLOGY. -
A central anti-inflammatory role of carboxypeptidase B in autoimmune arthritis
Song, J. J., Nishimura, T., Garcia, M., Myles, T., Du, X., Sharif, S., … Robinson, W. (2008). A central anti-inflammatory role of carboxypeptidase B in autoimmune arthritis. ARTHRITIS AND RHEUMATISM. SAN FRANCISCO,CA,CA,CA,CA,CA: WILEY-BLACKWELL. -
Thrombin-activatabte carboxypeptidase B prevents anti-collagen antibody induced arthritis
Song, J., Nishimura, T., Garcia, M., Myles, T., Ho, P., Du, X., … Robinson, W. (2007). Thrombin-activatabte carboxypeptidase B prevents anti-collagen antibody induced arthritis. Presented at the 7th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, SAN DIEGO,CA,CA,CA,CA,CA: ACADEMIC PRESS INC ELSEVIER SCIENCE. -
Enhanced Abdominal Aortic Aneurysm (AAA) Formation in Procarboxypeptidase B (pCPB)-Deficient Mice
Tedesco, M. M., Sho, E., Nishimura, T., Sharif, S., Du, X., Dalman, R. L., & Leung, L. L. (2008). Enhanced Abdominal Aortic Aneurysm (AAA) Formation in Procarboxypeptidase B (pCPB)-Deficient Mice. CIRCULATION. NEW ORLEANS,LA,LA: LIPPINCOTT WILLIAMS & WILKINS. -
Thrombin-activatable fibrinolysis inhibitor (TAFI) regulates activated complement C5a in vivo.
Nishimura, T., Myles, T., Nagashima, M., MORSER, J., Pearl, R. G., & Leung, L. L. K. (2004). Thrombin-activatable fibrinolysis inhibitor (TAFI) regulates activated complement C5a in vivo. BLOOD, 104(11), 812A–812A. -
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (TAFIa) and platelets
Du, X.-Y., Zabel, B. A., Allen, S. J., Handel, T. M., Lee, P. P., Butcher, E. C., & Leung, L. L. (2007). Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (TAFIa) and platelets. BLOOD. ATLANTA,GA,GA,GA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
Anti-apoptosis is a prominent response of endothelial cells to inflammatory cytokine stimulation.
Zheng, Z., Ross, D. T., Brown, P. O., & Leung, L. L. K. (1999). Anti-apoptosis is a prominent response of endothelial cells to inflammatory cytokine stimulation. BLOOD. AMER SOC HEMATOLOGY. -
Identification of critical residues in thrombin mediating platelet activation.
HALL, S. W., Venkataraman, G., Thompson, D., & Leung, L. L. K. (1999). Identification of critical residues in thrombin mediating platelet activation. BLOOD. AMER SOC HEMATOLOGY. -
Platelet Interaction with Bone Marrow Derived CD34(+) Stem Cells: Potential Role of Chemoattractant Chemerin
Du, X.-Y., & Leung, L. L. (2008). Platelet Interaction with Bone Marrow Derived CD34(+) Stem Cells: Potential Role of Chemoattractant Chemerin. BLOOD. SAN FRANCISCO,CA,CA,CA,CA,CA,CA: AMER SOC HEMATOLOGY. -
An extensive interaction interface between thrombin and factor V is revealed by alanine scanning mutagenesis of thrombin.
Myles, T., Yun, T. H., HALL, S. W., & Leung, L. L. K. (2000). An extensive interaction interface between thrombin and factor V is revealed by alanine scanning mutagenesis of thrombin. BLOOD. AMER SOC HEMATOLOGY. -
Dextran sulfate-mediated thrombin activation of factor XI requires anion binding exosite II.
Yun, T. H., Myles, T., & Leung, L. L. K. (2001). Dextran sulfate-mediated thrombin activation of factor XI requires anion binding exosite II. BLOOD. AMER SOC HEMATOLOGY. -
GP Ib is a functional thrombin receptor on platelets.
Ramakrishnan, V., Deguzman, F., Bao, M., HALL, S. W., Leung, L. L., & Phillips, D. R. (2000). GP Ib is a functional thrombin receptor on platelets. BLOOD. AMER SOC HEMATOLOGY. -
Molecular mapping of the thrombin-heparin cofactor II complex.
Fortenberry, Y. M., Gentry, H. R., Myles, T., Leung, L. L. K., & Church, F. C. (2001). Molecular mapping of the thrombin-heparin cofactor II complex. BLOOD. AMER SOC HEMATOLOGY. -
Thrombin-cleaved osteopontin is regulated by thrombin-activatable carboxypeptidase B in rheumatoid arthritis.
Myles, T., Sharif, S. A., Du, X.-Y., Song, J. J., Elizabeth, P., Robinson, W. H., & Leung, L. L. (2007). Thrombin-cleaved osteopontin is regulated by thrombin-activatable carboxypeptidase B in rheumatoid arthritis. BLOOD. ATLANTA,GA,GA,GA,GA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells
Zhang, W., Chuang, Y.-J., Jin, T., Swanson, R., Xiong, Y., Leung, L., & Olson, S. T. (2006). Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells. CANCER RESEARCH, 66(10), 5047–5055. -
Differential Gene Expression in Thrombomodulin (TM; CD141)(+) and TM(-) Dendritic Cell Subsets.
Toda, M., Shao, Z., Yamaguchi, K. D., Takagi, T., D'Alessandro-Gabazza, C. N., Taguchi, O., … Morser, J. (2013). Differential Gene Expression in Thrombomodulin (TM; CD141)(+) and TM(-) Dendritic Cell Subsets. PloS One, 8(8). -
Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis.
Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.), 66(1), 101–6. -
A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V
Ramakrishnan, V., Deguzman, F., Bao, M., HALL, S. W., Leung, L. L., & Phillips, D. R. (2001). A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(4), 1823–28. -
Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis
Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis. ARTHRITIS & RHEUMATOLOGY, 66(1), 101–6. -
Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells
Zhang, W. Q., Chuang, Y. J., Swanson, R., Li, J., Seo, K. G., Leung, L., … Olson, S. T. (2004). Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells. BLOOD, 103(4), 1185–91. -
Thrombin Cleavage of Osteopontin Disrupts a Pro-chemotactic Sequence for Dendritic Cells, Which Is Compensated by the Release of Its Pro-chemotactic C-terminal Fragment
Shao, Z., Morser, J., & Leung, L. L. K. (2014). Thrombin Cleavage of Osteopontin Disrupts a Pro-chemotactic Sequence for Dendritic Cells, Which Is Compensated by the Release of Its Pro-chemotactic C-terminal Fragment. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(39), 27146–58. -
Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.
Shao, Z., Morser, J., & Leung, L. L. K. (2014). Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment. Journal of Biological Chemistry, 289(39), 27146–58. -
Plasmin as a complement C5 convertase.
Leung, L. L., & Morser, J. (2016). Plasmin as a complement C5 convertase. EBioMedicine, 5, 20–21. -
Chemerin Activation in Human Obesity
Chang, S.-S., Eisenberg, D., Zhao, L., Adams, C., Leib, R., Morser, J., & Leung, L. (2016). Chemerin Activation in Human Obesity. OBESITY, 24(7), 1522–29. -
Prochemerin cleavage by factor XIa links coagulation and inflammation
Ge, X., Yamaguchi, Y., Zhao, L., Bury, L., Gresele, P., Berube, C., … Morser, J. (2018). Prochemerin cleavage by factor XIa links coagulation and inflammation. BLOOD, 131(3), 353–64. -
Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma
Xiong, G., Lingampalli, N., Koltsov, J. C. B., Leung, L. L., Bhutani, N., Robinson, W. H., & Chu, C. R. (2018). Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma. AMERICAN JOURNAL OF SPORTS MEDICINE, 46(2), 409–19. -
Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients.
Zhao, L., Yamaguchi, Y., Ge, X., Robinson, W. H., Morser, J., & Leung, L. L. (2018). Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients. Arthritis Research & Therapy, 20(1), 132. -
Dynamic and tissue-specific proteolytic processing of chemerin in obese mice.
Zhao, L., Yamaguchi, Y., Shen, W.-J., Morser, J., & Leung, L. L. (2018). Dynamic and tissue-specific proteolytic processing of chemerin in obese mice. PloS One, 13(8), e0202780. -
Decoding the Genomics of Abdominal Aortic Aneurysm.
Li, J., Pan, C., Zhang, S., Spin, J. M., Deng, A., Leung, L. L., … Snyder, M. (2018). Decoding the Genomics of Abdominal Aortic Aneurysm. Cell, 174(6), 1361. -
Carboxypeptidase B2 Down-Regulates Osteoclast Activation In Inflammation.
Song, J. J., Lee, S.-W., Park, Y.-B., Lee, S. K., Leung, L., & Robinson, W. H. (2013). Carboxypeptidase B2 Down-Regulates Osteoclast Activation In Inflammation. ARTHRITIS AND RHEUMATISM. WILEY-BLACKWELL. -
Antibody-mediated targeting of cleavage-specific OPN-T cell interactions.
Wanko, B., Tardelli, M., Jurets, A., Neuhofer, A., Prager, G., Morser, J., … Stulnig, T. M. (2019). Antibody-mediated targeting of cleavage-specific OPN-T cell interactions. PloS One, 14(4), e0214938. -
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.
Yun, T. H., Baglia, F. A., Myles, T., Navaneetham, D., López, J. A., Walsh, P. N., & Leung, L. L. (2003). Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. The Journal of Biological Chemistry, 278(48), 48112–9. -
Antibody-mediated targeting of cleavage-specific OPN-T cell interactions
Wanko, B., Tardelli, M., Juerets, A., Neuhofer, A., Prager, G., Morser, J., … Stulnig, T. M. (2019). Antibody-mediated targeting of cleavage-specific OPN-T cell interactions. PLOS ONE, 14(4). -
Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients
Zhao, L., Yamaguchi, Y., Ge, X., Robinson, W. H., Morser, J., & Leung, L. L. K. (2018). Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients. ARTHRITIS RESEARCH & THERAPY, 20. -
Decoding the Genomics of Abdominal Aortic Aneurysm
Li, J., Pan, C., Zhang, S., Spin, J. M., Deng, A., Leung, L. L. K., … Snyder, M. (2018). Decoding the Genomics of Abdominal Aortic Aneurysm. CELL, 174(6), 1361-+. -
Deficiency of Either Carboxypeptidase B2 or Carboxypeptidase N Exacerbated Disease Activity in a Mouse Model of Hemolytic Uremic Syndrome
Leung, L. L., Shao, Z., Nishimura, T., Zhou, Q., Gigliello, L., Castro, P., … Morser, J. (2016). Deficiency of Either Carboxypeptidase B2 or Carboxypeptidase N Exacerbated Disease Activity in a Mouse Model of Hemolytic Uremic Syndrome. BLOOD. AMER SOC HEMATOLOGY. -
Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.
Zhang, Y., Shen, W.-J., Qiu, S., Yang, P., Dempsey, G., Zhao, L., … Morser, J. (2021). Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 35(7), e21687. -
Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice.
Zhou, Q., Zhao, L., Shao, Z., Declerck, P., Leung, L. L., & Morser, J. (2021). Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice. Journal of Thrombosis and Haemostasis : JTH. -
Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity.
Peraramelli, S., Zhou, Q., Zhou, Q., Wanko, B., Zhao, L., Nishimura, T., … Leung, L. L. (1800). Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity. Journal of Thrombosis and Haemostasis : JTH. -
Chemerin Forms: Their Generation and Activity.
Zhao, L., Leung, L. L., & Morser, J. (2022). Chemerin Forms: Their Generation and Activity. Biomedicines, 10(8). -
Simultaneous Cases of Carfilzomib-Induced Thrombotic Microangiopathy in 2 Patients With Multiple Myeloma.
Myall, N. J., Wang, S. X., Hall, E. T., Witteles, W. H., Leung, L., Dunn, T. J., & Hong, W.-J. J. (2022). Simultaneous Cases of Carfilzomib-Induced Thrombotic Microangiopathy in 2 Patients With Multiple Myeloma. Federal Practitioner : for the Health Care Professionals of the VA, DoD, and PHS, 39(Suppl 3), S56–S62. -
Dynamic and tissue-specific proteolytic processing of chemerin in obese mice
Zhao, L., Yamaguchi, Y., Shen, W.-J., Morser, J., & Leung, L. L. K. (2018). Dynamic and tissue-specific proteolytic processing of chemerin in obese mice. PLOS ONE, 13(8). -
Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils
Navazo, M. D., Daviet, L., Savill, J., Ren, Y., Leung, L. L., & McGregor, J. L. (1996). Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils. JOURNAL OF BIOLOGICAL CHEMISTRY, 271(26), 15381–15385. -
Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain
Nogami, K., Zhou, Q., Myles, T., Leung, L. L., Wakabayashi, H., & Fay, P. J. (2005). Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(18), 18476–18487. -
Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation - Competition for cofactor sites on thrombin determines its fate
Philippou, H., Rance, J., Myles, T., Hall, S. W., Ariens, R. A., Grant, P. J., … Lane, D. A. (2003). Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation - Competition for cofactor sites on thrombin determines its fate. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(34), 32020–32026. -
Thrombin Cleavage of Osteopontin and the Host Anti-Tumor Immune Response.
Leung, L. L., Myles, T., & Morser, J. (2023). Thrombin Cleavage of Osteopontin and the Host Anti-Tumor Immune Response. Cancers, 15(13).
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Palo Alto, CAHematologic Cancer Program
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Make An Appointment More Clinic Information » Getting Here »Hereditary Hemorrhagic Telangiectasia Center of Excellence Stanford, CA
Stanford, CAHereditary Hemorrhagic Telangiectasia Center of Excellence
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Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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