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Biography
I am an Infectious Diseases physician-scientist with a research program in human immunology of malaria and clinical trials of immune modulatory interventions. Our group has been conducting detailed longitudinal cohort studies in children and pregnant women in order to study how repeated malaria shapes the cellular immune response. We are also studying how malaria control interventions such as antimalarial chemoprevention and vector control shape the acquisition and/or maintenance of protective immunity to malaria. We have expanded this work to not only include studying the mechanisms driving naturally acquired immunity to malaria, but other infectious diseases, including SARS CoV-2. We have also lead and/or participated in studies evaluating therapeutic strategies for patients with mild to moderate COVID-19.
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Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Infectious Disease (2011)
- Certificate, University of California, San Francisco, Advanced Training in Clinical Research
- Postdoctoral, University of California, San Francisco, Immunology
- Fellowship, University of California, San Francisco, Infectious Diseases
- Residency, University of California, San Francisco, Internal Medicine
- M.D., Harvard Medical School, Medicine
Honors & Awards
- Rosenkranz Prize, Stanford University (Sep 2018)
- Young Physician Scientist Award, American Society of Clinical Investigation (April 2018)
Publications
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Comparisons of CD8(+) T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness
Jagannathan, P., Osborne, C. M., Royce, C., Manion, M. M., Tilton, J. C., Li, L., … Migueles, S. A. (2009). Comparisons of CD8(+) T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness. JOURNAL OF VIROLOGY, 83(6), 2728–2742. -
Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation
Prahl, M., Jagannathan, P., McIntyre, T. I., Auma, A., Farrington, L., Wamala, S., … Feeney, M. E. (2016). Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation. MALARIA JOURNAL, 15. -
Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda
Rek, J., Katrak, S., Obasi, H., Nayebare, P., Katureebe, A., Kakande, E., … Greenhouse, B. (2016). Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. MALARIA JOURNAL, 15. -
Reductions in malaria in pregnancy and adverse birth outcomes following indoor residual spraying of insecticide in Uganda
Muhindo, M. K., Kakuru, A., Natureeba, P., Awori, P., Olwoch, P., Ategeka, J., … Jagannathan, P. (2016). Reductions in malaria in pregnancy and adverse birth outcomes following indoor residual spraying of insecticide in Uganda. MALARIA JOURNAL, 15. -
Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children.
Rodriguez-Barraquer, I., Arinaitwe, E., Jagannathan, P., Boyle, M. J., Tappero, J., Muhindo, M., … Greenhouse, B. (2016). Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children. Journal of Infectious Diseases, 214(7), 1072–80. -
Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10
Jagannathan, P., Bowen, K., Nankya, F., McIntyre, T. I., Auma, A., Wamala, S., … Feeney, M. E. (2016). Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10. JOURNAL OF INFECTIOUS DISEASES, 214(2), 329–38. -
B cell sub-types following acute malaria and associations with clinical immunity (vol 15, 139, 2016)
Sullivan, R. T., Ssewanyana, I., Wamala, S., Nankya, F., Jagannathan, P., Tappero, J. W., … Greenhouse, B. (2016). B cell sub-types following acute malaria and associations with clinical immunity (vol 15, 139, 2016). MALARIA JOURNAL, 15. -
Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy
Kakuru, A., Jagannathan, P., Muhindo, M. K., Natureeba, P., Awori, P., Nakalembe, M., … Dorsey, G. (2016). Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy. NEW ENGLAND JOURNAL OF MEDICINE, 374(10), 928–939. -
Frequent Malaria Drives Progressive V delta 2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood
Farrington, L. A., Jagannathan, P., McIntyre, T. I., Vance, H. M., Bowen, K., Boyle, M. J., … Feeney, M. E. (2016). Frequent Malaria Drives Progressive V delta 2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood. JOURNAL OF INFECTIOUS DISEASES, 213(9), 1483–90. -
Intermittent Preventive Treatment with Dihydroartemisinin-piperaquine for the Prevention of Malaria among HIV-infected Pregnant Women.
Natureeba, P., Kakuru, A., Muhindo, M., Littmann, E., Ochieng, T., Ategeka, J., … Dorsey, G. (2017). Intermittent Preventive Treatment with Dihydroartemisinin-piperaquine for the Prevention of Malaria among HIV-infected Pregnant Women. Journal of Infectious Diseases. -
Antiretroviral Therapy With Efavirenz Accentuates Pregnancy-Associated Reduction of Dihydroartemisinin-Piperaquine Exposure During Malaria Chemoprevention.
Kajubi, R., Huang, L., Jagannathan, P., Chamankhah, N., WERE, M., Ruel, T., … Aweeka, F. T. (2017). Antiretroviral Therapy With Efavirenz Accentuates Pregnancy-Associated Reduction of Dihydroartemisinin-Piperaquine Exposure During Malaria Chemoprevention. Clinical Pharmacology & Therapeutics. -
Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children
Sundell, K., Jagannathan, P., Huang, L., Bigira, V., Kapisi, J., Kakuru, M. M., … Aweeka, F. (2015). Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children. MALARIA JOURNAL, 14. -
Decline of FoxP3+Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria
Boyle, M. J., Jagannathan, P., Farrington, L. A., Eccles-James, I., Wamala, S., McIntyre, T. I., … Feeney, M. E. (2015). Decline of FoxP3+Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria. PLOS PATHOGENS, 11(7). -
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure
Sullivan, R. T., Kim, C. C., Fontana, M. F., Feeney, M. E., Jagannathan, P., Boyle, M. J., … Greenhouse, B. (2015). FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. PLOS PATHOGENS, 11(5). -
Effector Phenotype of Plasmodium falciparum-Specific CD4(+) T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations
Boyle, M. J., Jagannathan, P., Bowen, K., McIntyre, T. I., Vance, H. M., Farrington, L. A., … Feeney, M. E. (2015). Effector Phenotype of Plasmodium falciparum-Specific CD4(+) T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations. JOURNAL OF INFECTIOUS DISEASES, 212(3), 416–25. -
IFN gamma Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection
Jagannathan, P., Nankya, F., Stoyanov, C., Eccles-James, I., Sikyomu, E., Naluwu, K., … Feeney, M. E. (2015). IFN gamma Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection. JOURNAL OF INFECTIOUS DISEASES, 211(12), 1987–1996. -
Loss and dysfunction of Vd2? ?d T cells are associated with clinical tolerance to malaria.
Jagannathan, P., Kim, C. C., Greenhouse, B., Nankya, F., Bowen, K., Eccles-James, I., … Feeney, M. E. (2014). Loss and dysfunction of Vd2? ?d T cells are associated with clinical tolerance to malaria. Science Translational Medicine, 6(251), 251ra117-? -
Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria
Muhindo, M. K., Kakuru, A., Jagannathan, P., Talisuna, A., Osilo, E., Orukan, F., … Dorsey, G. (2014). Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria. MALARIA JOURNAL, 13. -
Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial
Kamya, M. R., Kapisi, J., Bigira, V., Clark, T. D., Kinara, S., Mwangwa, F., … Dorsey, G. (2014). Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS, 28(18), 2701–2709. -
IFN gamma/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children
Jagannathan, P., Eccles-James, I., Bowen, K., Nankya, F., Auma, A., Wamala, S., … Feeney, M. E. (2014). IFN gamma/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children. PLOS PATHOGENS, 10(1). -
The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young Ugandan Children
Kakuru, A., Jagannathan, P., Arinaitwe, E., Wanzira, H., Muhindo, M., Bigira, V., … Dorsey, G. (2013). The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young Ugandan Children. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 88(4), 736–743. -
Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series
Jagannathan, P., Davis, E., Jacobson, M., & Huang, L. (2009). Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series. AIDS, 23(13), 1794–1796. -
Monitoring antimalarial safety and tolerability in clinical trials: A case study from Uganda
Staedke, S. G., Jagannathan, P., Yeka, A., Bukirwa, H., Banek, K., Maiteki-Sebuguzi, C., … Talisuna, A. O. (2008). Monitoring antimalarial safety and tolerability in clinical trials: A case study from Uganda. MALARIA JOURNAL, 7. -
Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children
Maiteki-Sebuguzi, C., Jagannathan, P., Yau, V. M., Clark, T. D., Njama-Meya, D., Nzarubara, B., … Staedke, S. G. (2008). Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. MALARIA JOURNAL, 7. -
Limitations in knowledge of HIV transmission among HIV-positive patients accessing case management services in a resource-poor setting
Fawzi, M. C. S., Jagannathan, P., Cabral, J., Banares, R., Salazar, J., Farmer, P., & BEHFOROUZ, H. (2006). Limitations in knowledge of HIV transmission among HIV-positive patients accessing case management services in a resource-poor setting. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 18(7), 764–771. -
Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
Jagannathan, P., Muhindo, M. K., Kakuru, A., Arinaitwe, E., Greenhouse, B., Tappero, J., … Dorsey, G. (2012). Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. MALARIA JOURNAL, 11. -
Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts
Shubov, A., Jagannathan, P., & Chin-Hong, P. V. (2011). Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts. TRANSPLANT INFECTIOUS DISEASE, 13(5), 536–539. -
CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero.
Prahl, M., Jagannathan, P., McIntyre, T. I., Auma, A., Wamala, S., Nalubega, M., … Feeney, M. E. (2017). CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open Forum Infectious Diseases, 4(1), ofx022-? -
Vd2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.
Jagannathan, P., Lutwama, F., Boyle, M. J., Nankya, F., Farrington, L. A., McIntyre, T. I., … Feeney, M. E. (2017). Vd2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. Scientific Reports, 7(1), 11487. -
Protective effect of indoor residual spraying of insecticide on preterm birth among pregnant women with HIV in Uganda: A secondary data analysis.
Roh, M. E., Shiboski, S., Natureeba, P., Kakuru, A., Muhindo, M., Ochieng, T., … Dorsey, G. (2017). Protective effect of indoor residual spraying of insecticide on preterm birth among pregnant women with HIV in Uganda: A secondary data analysis. The Journal of Infectious Diseases. -
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes.
Kapisi, J., Kakuru, A., Jagannathan, P., Muhindo, M. K., Natureeba, P., Awori, P., … Gaw, S. L. (2017). Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes. Malaria Journal, 16(1), 400. -
Impact of intermittent preventive treatment during pregnancy on Plasmodium falciparum drug resistance-mediating polymorphisms in Uganda.
Conrad, M. D., Mota, D., Foster, M., Tukwasibwe, S., Legac, J., Tumwebaze, P., … Rosenthal, P. J. (2017). Impact of intermittent preventive treatment during pregnancy on Plasmodium falciparum drug resistance-mediating polymorphisms in Uganda. The Journal of Infectious Diseases. -
Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children.
Farrington, L., Vance, H., Rek, J., Prahl, M., Jagannathan, P., Katureebe, A., … Feeney, M. E. (2017). Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children. Malaria Journal, 16(1), 499. -
Predicting optimal dihydroartemisinin-piperaquine regimens to prevent malaria during pregnancy for HIV-infected women receiving efavirenz.
Wallender, E., Vucicevic, K., Jagannathan, P., Huang, L., Natureeba, P., Kakura, A., … Savic, R. M. (2017). Predicting optimal dihydroartemisinin-piperaquine regimens to prevent malaria during pregnancy for HIV-infected women receiving efavirenz. The Journal of Infectious Diseases. -
The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission.
Boyle, M. J., Jagannathan, P., Bowen, K., McIntyre, T. I., Vance, H. M., Farrington, L. A., … Feeney, M. E. (2017). The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission. Frontiers in Immunology, 8, 1329. -
Response to "Antiretroviral Therapy With Efavirenz in HIV-Infected Pregnant Women: Understanding the Possible Mechanisms for Drug-Drug Interaction".
Jagannathan, P., Kajubi, R., & Aweeka, F. T. (2018). Response to "Antiretroviral Therapy With Efavirenz in HIV-Infected Pregnant Women: Understanding the Possible Mechanisms for Drug-Drug Interaction". Clinical Pharmacology and Therapeutics. -
Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.
Savic, R. M., Jagannathan, P., Kajubi, R., Huang, L., Zhang, N., Were, M., … Aweeka, F. T. (2018). Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
Jagannathan, P., Kakuru, A., Okiring, J., Muhindo, M. K., Natureeba, P., Nakalembe, M., … Dorsey, G. (2018). Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. PLoS Medicine, 15(7), e1002606. -
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure.
Rodriguez-Barraquer, I., Arinaitwe, E., Jagannathan, P., Kamya, M. R., Rosenthal, P. J., Rek, J., … Greenhouse, B. (2018). Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure. ELife, 7. -
Malaria in pregnancy shapes the development of fetal and infant immunity.
Harrington, W. E., Kakuru, A., & Jagannathan, P. (2018). Malaria in pregnancy shapes the development of fetal and infant immunity. Parasite Immunology, e12573. -
In utero priming of highly functional effector T cell responses to human malaria.
Odorizzi, P. M., Jagannathan, P., McIntyre, T. I., Budker, R., Prahl, M., Auma, A., … Feeney, M. E. (2018). In utero priming of highly functional effector T cell responses to human malaria. Science Translational Medicine, 10(463). -
gamma delta T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance
Dantzler, K. W., & Jagannathan, P. (2018). gamma delta T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance. FRONTIERS IN IMMUNOLOGY, 9. -
How does malaria in pregnancy impact malaria risk in infants?
Jagannathan, P. (2018). How does malaria in pregnancy impact malaria risk in infants? BMC Medicine, 16(1), 212. -
Modeling prevention of malaria and selection of drug resistance with different dosing schedules of dihydroartemisinin-piperaquine preventive therapy during pregnancy in Uganda.
Wallender, E., Zhang, N., Conrad, M., Kakuru, A., Muhindo, M., Tumwebaze, P., … Savic, R. M. (2018). Modeling prevention of malaria and selection of drug resistance with different dosing schedules of dihydroartemisinin-piperaquine preventive therapy during pregnancy in Uganda. Antimicrobial Agents and Chemotherapy. -
Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.
Conroy, A. L., Bangirana, P., Muhindo, M. K., Kakuru, A., Jagannathan, P., Opoka, R. O., … John, C. C. (2019). Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins. The American Journal of Tropical Medicine and Hygiene. -
Impact of microscopic and submicroscopic parasitemia during pregnancy on placental malaria in a high-transmission setting in Uganda.
Briggs, J., Ategeka, J., Kajubi, R., Ochieng, T., Kakuru, A., Ssemanda, C., … Dorsey, G. (2019). Impact of microscopic and submicroscopic parasitemia during pregnancy on placental malaria in a high-transmission setting in Uganda. The Journal of Infectious Diseases. -
Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial.
Kajubi, R., Ochieng, T., Kakuru, A., Jagannathan, P., Nakalembe, M., Ruel, T., … Dorsey, G. (2019). Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial. Lancet (London, England). -
EVALUATION OF ACCURACY OF MAGNETO-OPTICAL METHOD FOR THE DETECTION OF MALARIA PARASITES
Jagannathan, P., Adrama, H., Kajubi, R., Clark, T., Dorsey, G., Kamya, M., … Thota, P. (2018). EVALUATION OF ACCURACY OF MAGNETO-OPTICAL METHOD FOR THE DETECTION OF MALARIA PARASITES. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 99(4), 538. -
?d T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.
Dantzler, K. W., & Jagannathan, P. (2018). ?d T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance. Frontiers in Immunology, 9, 2445. -
Erratum to: B cell sub-types following acute malaria and associations with clinical immunity.
Sullivan, R. T., Ssewanyana, I., Wamala, S., Nankya, F., Jagannathan, P., Tappero, J. W., … Greenhouse, B. (2016). Erratum to: B cell sub-types following acute malaria and associations with clinical immunity. Malaria Journal, 15, 188. -
B cell sub-types following acute malaria and associations with clinical immunity.
Sullivan, R. T., Ssewanyana, I., Wamala, S., Nankya, F., Jagannathan, P., Tappero, J. W., … Sullivan, R. (2016). B cell sub-types following acute malaria and associations with clinical immunity. Malaria Journal, 15, 139. -
Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins
Conroy, A. L., Bangirana, P., Muhindo, M. K., Kakuru, A., Jagannathan, P., Opoka, R. O., … John, C. C. (2019). Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 100(3), 552–55. -
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
Rodriguez-Barraquer, I., Arinaitwe, E., Jagannathan, P., Kamya, M. R., Rosenthal, P. J., Rek, J., … Greenhouse, B. (2018). Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure. ELIFE, 7. -
Malaria smear positivity among Kenyan children peaks at intermediate temperatures as predicted by ecological models.
Shah, M. M., Krystosik, A. R., Ndenga, B. A., Mutuku, F. M., Caldwell, J. M., Otuka, V., … LaBeaud, A. D. (2019). Malaria smear positivity among Kenyan children peaks at intermediate temperatures as predicted by ecological models. Parasites & Vectors, 12(1), 288. -
Reduced exposure to piperaquine in young children, compared to adults, in children receiving dihydroartemisinin-piperaquine as malaria chemoprevention.
Whalen, M. E., Kajubi, R., Chamankhah, N., Huang, L., Orukan, F., Wallender, E., … Aweeka, F. T. (2019). Reduced exposure to piperaquine in young children, compared to adults, in children receiving dihydroartemisinin-piperaquine as malaria chemoprevention. Clinical Pharmacology and Therapeutics. -
Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda
Wallender, E., Zhang, N., Conrad, M., Kakuru, A., Muhindo, M., Tumwebaze, P., … Savic, R. M. (2019). Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 63(2). -
Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial.
Muhindo, M. K., Jagannathan, P., Kakuru, A., Opira, B., Olwoch, P., Okiring, J., … Kamya, M. R. (2019). Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial. The Lancet. Infectious Diseases. -
Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda
Briggs, J., Ategeka, J., Kajubi, R., Ochieng, T., Kakuru, A., Ssemanda, C., … Dorsey, G. (2019). Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda. JOURNAL OF INFECTIOUS DISEASES, 220(3), 457–66. -
Emerging role of gammadelta T cells in vaccine-mediated protection from infectious diseases.
Dantzler, K. W., de la Parte, L., & Jagannathan, P. (2019). Emerging role of gammadelta T cells in vaccine-mediated protection from infectious diseases. Clinical & Translational Immunology, 8(8), e1072. -
Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial
Kajubi, R., Ochieng, T., Kakuru, A., Jagannathan, P., Nakalembe, M., Ruel, T., … Dorsey, G. (2019). Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial. LANCET, 393(10179), 1428–39. -
MECHANISMS DRIVING ALTERED V Delta 2+Gamma Delta T CELL FUNCTION DURING RECURRENT MALARIA INFECTION
Dantzler, K. W., Klemm, S., Polidoro, R., Rao, A., Junquiera, C., Dvorak, M., … Jagannathan, P. (2019). MECHANISMS DRIVING ALTERED V Delta 2+Gamma Delta T CELL FUNCTION DURING RECURRENT MALARIA INFECTION. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
ASSOCIATION BETWEEN PLACENTAL MALARIA AND THE INCIDENCE OF MALARIA IN INFANTS BORN TO HIV-UNINFECTED UGANDAN MOTHERS LIVING IN A HIGH MALARIA TRANSMISSION SETTING
Kakuru, A., Staedke, S., Chandramohan, D., Kajubi, R., Andra, T., Adrama, H. A. H., … Jagannathan, P. (2019). ASSOCIATION BETWEEN PLACENTAL MALARIA AND THE INCIDENCE OF MALARIA IN INFANTS BORN TO HIV-UNINFECTED UGANDAN MOTHERS LIVING IN A HIGH MALARIA TRANSMISSION SETTING. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101, 518. -
PHARMACOKINETIC/PHARMACODYNAMIC MODELING TO IDENTIFY OPTIMAL DIHYDROARTEMISININ-PIPERAQUINE INTERMITTENT PREVENTIVE TREATMENT REGIMENS FOR YOUNG UGANDAN CHILDREN
Wallender, E., Hughes, E., Kakuru, A., Jagannathan, P., Muhindo, M. K., Opira, B., … Savic, R. M. (2019). PHARMACOKINETIC/PHARMACODYNAMIC MODELING TO IDENTIFY OPTIMAL DIHYDROARTEMISININ-PIPERAQUINE INTERMITTENT PREVENTIVE TREATMENT REGIMENS FOR YOUNG UGANDAN CHILDREN. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101, 521. -
VALIDATION OF PIPERAQUINE CONCENTRATIONS PROTECTIVE AGAINST PLASMODIUM FALCIPARUM INFECTION WHEN DIHYDROARTEMISININ-PIPERAQUINE IS GIVEN ASINTERMITTENT PREVENTIVE TREATMENT DURING PREGNANCY
Hughes, E., Kajubi, R., Wallender, E., Huang, L., Ochieng, T., Kakuru, A., … Savic, R. (2019). VALIDATION OF PIPERAQUINE CONCENTRATIONS PROTECTIVE AGAINST PLASMODIUM FALCIPARUM INFECTION WHEN DIHYDROARTEMISININ-PIPERAQUINE IS GIVEN ASINTERMITTENT PREVENTIVE TREATMENT DURING PREGNANCY. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101, 113. -
SEVERITY OF MALARIA IN A BIRTH COHORT OF INFANTS LIVING IN A HIGHLY ENDEMIC AREA OF UGANDA
Zehner, N. A., Andra, T., Kajubi, R., Ssewanyana, I., Conrad, M., Nankya, F., … Jagannathan, P. (2019). SEVERITY OF MALARIA IN A BIRTH COHORT OF INFANTS LIVING IN A HIGHLY ENDEMIC AREA OF UGANDA. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
Relationships between measures of malaria at delivery and adverse birth outcomes in a high-transmission area of Uganda.
Ategeka, J., Kakuru, A., Kajubi, R., Wasswa, R., Ochokoru, H., Arinaitwe, E., … Dorsey, G. (2020). Relationships between measures of malaria at delivery and adverse birth outcomes in a high-transmission area of Uganda. The Journal of Infectious Diseases. -
Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants.
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The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.
Kamya, M. R., Kakuru, A., Muhindo, M., Arinaitwe, E., Nankabirwa, J. I., Rek, J., … Dorsey, G. (2020). The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. The American Journal of Tropical Medicine and Hygiene. -
FcRn, but not Fc?Rs, drives maternal-fetal transplacental transport of human IgG antibodies.
Borghi, S., Bournazos, S., Thulin, N. K., Li, C., Gajewski, A., Sherwood, R. W., … Wang, T. T. (2020). FcRn, but not Fc?Rs, drives maternal-fetal transplacental transport of human IgG antibodies. Proceedings of the National Academy of Sciences of the United States of America. -
Symptomatic SARS-CoV-2 infections display specific IgG Fc structures.
Chakraborty, S., Edwards, K., Buzzanco, A. S., Memoli, M. J., Sherwood, R., Mallajosyula, V., … Wang, T. T. (2020). Symptomatic SARS-CoV-2 infections display specific IgG Fc structures. MedRxiv : the Preprint Server for Health Sciences. -
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria.
Tukwasibwe, S., Nakimuli, A., Traherne, J., Chazara, O., Jayaraman, J., Trowsdale, J., … Colucci, F. (2020). Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cellular & Molecular Immunology. -
Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: a randomized controlled trial.
Kakuru, A., Jagannathan, P., Kajubi, R., Ochieng, T., Ochokoru, H., Nakalembe, M., … Dorsey, G. (2020). Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: a randomized controlled trial. BMC Medicine, 18(1), 207. -
Generation of a malaria negative Ugandan birth weight standard for the diagnosis of small for gestational age.
Zakama, A. K., Weekes, T., Kajubi, R., Kakuru, A., Ategeka, J., Kamya, M., … Gaw, S. L. (2020). Generation of a malaria negative Ugandan birth weight standard for the diagnosis of small for gestational age. PloS One, 15(10), e0240157. -
Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women.
Hughes, E., Imperial, M., Wallender, E., Kajubi, R., Huang, L., Jagannathan, P., … Savic, R. M. (2020). Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women. Antimicrobial Agents and Chemotherapy. -
Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response.
Murugesan, K., Jagannathan, P., Pham, T. D., Pandey, S., Bonilla, H. F., Jacobson, K., … Banaei, N. (2020). Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Opsonized antigen activates Vdelta2+ T cells via CD16/FCgammaRIIIa in individuals with chronic malaria exposure.
Farrington, L. A., Callaway, P. C., Vance, H. M., Baskevitch, K., Lutz, E., Warrier, L., … Feeney, M. E. (2020). Opsonized antigen activates Vdelta2+ T cells via CD16/FCgammaRIIIa in individuals with chronic malaria exposure. PLoS Pathogens, 16(10), e1008997. -
Sex-based differences in clearance of chronic Plasmodium falciparum infection.
Briggs, J., Teyssier, N., Nankabirwa, J. I., Rek, J., Jagannathan, P., Arinaitwe, E., … Greenhouse, B. (2020). Sex-based differences in clearance of chronic Plasmodium falciparum infection. ELife, 9. -
Proinflammatory IgG Fc structures in patients with severe COVID-19
Chakraborty, S., Gonzales, J., Edwards, K., Mallajosyulla, V., Buzzanco, A. S., Sherwood, R., … Tan, G. S. (2020). Proinflammatory IgG Fc structures in patients with severe COVID-19. Nature Immunology. -
Infant sex modifies associations between placental malaria and risk of malaria in infancy.
Kakuru, A., Roh, M. E., Kajubi, R., Ochieng, T., Ategeka, J., Ochokoru, H., … Jagannathan, P. (2020). Infant sex modifies associations between placental malaria and risk of malaria in infancy. Malaria Journal, 19(1), 449. -
Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.
Prahl, M., Odorizzi, P., Gingrich, D., Muhindo, M., McIntyre, T., Budker, R., … Feeney, M. E. (2021). Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy. Nature Communications, 12(1), 132. -
Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic.
Jacobson, K. B., Rao, M., Bonilla, H., Subramanian, A., Hack, I., Madrigal, M., … Grant, P. (2021). Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.
Tukwasibwe, S., Traherne, J. A., Chazara, O., Jayaraman, J., Trowsdale, J., Moffett, A., … Nakimuli, A. (2021). Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. Malaria Journal, 20(1), 111. -
Gestational age dating using newborn metabolic screening: A validation study in Busia, Uganda.
Oltman, S. P., Jasper, E. A., Kajubi, R., Ochieng, T., Kakuru, A., Adrama, H., … Jelliffe-Pawlowski, L. L. (2021). Gestational age dating using newborn metabolic screening: A validation study in Busia, Uganda. Journal of Global Health, 11, 04012. -
Age-related Changes in Malaria Clinical Phenotypes During Infancy are Modified by Sickle Cell Trait.
Zehner, N., Adrama, H., Kakuru, A., Andra, T., Kajubi, R., Conrad, M., … Jagannathan, P. (2021). Age-related Changes in Malaria Clinical Phenotypes During Infancy are Modified by Sickle Cell Trait. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Malaria PK/PD and the role pharmacometrics can play in the global health arena: Malaria treatment regimens for vulnerable populations.
Hughes, E., Wallender, E., Ali, A. M., Jagannathan, P., & Savic, R. M. (2021). Malaria PK/PD and the role pharmacometrics can play in the global health arena: Malaria treatment regimens for vulnerable populations. Clinical Pharmacology and Therapeutics. -
Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial.
Jagannathan, P., Andrews, J. R., Bonilla, H., Hedlin, H., Jacobson, K. B., Balasubramanian, V., … Singh, U. (2021). Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. Nature Communications, 12(1), 1967. -
Immunity after SARS-CoV-2 infections.
Jagannathan, P., & Wang, T. T. (2021). Immunity after SARS-CoV-2 infections. Nature Immunology. -
Peripheral Plasmodium falciparum infection in early pregnancy is associated with increased maternal microchimerism in the offspring.
Simon, N., Shallat, J., Houck, J., Jagannathan, P., Prahl, M., Muhindo, M. K., … Harrington, W. E. (2021). Peripheral Plasmodium falciparum infection in early pregnancy is associated with increased maternal microchimerism in the offspring. The Journal of Infectious Diseases. -
SARS-CoV-2 subgenomic RNA kinetics in longitudinal clinical samples
Verma, R., Kim, E., Martinez, G., Jagannathan, P., Rustagi, A., Parsonnet, J., … Andrews, J. (2021). SARS-CoV-2 subgenomic RNA kinetics in longitudinal clinical samples. Open Forum Infectious Diseases. -
SARS-CoV-2 Antiviral Therapy.
Tao, K., Tzou, P. L., Nouhin, J., Bonilla, H., Jagannathan, P., & Shafer, R. W. (2021). SARS-CoV-2 Antiviral Therapy. Clinical Microbiology Reviews, e0010921. -
New-onset IgG autoantibodies in hospitalized patients with COVID-19.
Chang, S. E., Feng, A., Meng, W., Apostolidis, S. A., Mack, E., Artandi, M., … Utz, P. J. (2021). New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nature Communications, 12(1), 5417. -
Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nature Communications, 12(1), 5753. -
Standardized and optimized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Standardized and optimized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. MedRxiv : the Preprint Server for Health Sciences. -
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.
Wallender, E., Ali, A. M., Hughes, E., Kakuru, A., Jagannathan, P., Muhindo, M. K., … Savic, R. M. (2021). Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children. Nature Communications, 12(1), 6714. -
Publisher Correction: Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Publisher Correction: Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nature Communications, 12(1), 7100. -
Piperaquine induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women.
Hughes, E., Wallender, E., Kajubi, R., Jagannathan, P., Ochieng, T., Kakuru, A., … Savic, R. M. (2021). Piperaquine induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19.
Jacobson, K. B., Purington, N., Parsonnet, J., Andrews, J., Balasubramanian, V., Bonilla, H., … Jagannathan, P. (2021). Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19. Diagnostic Microbiology and Infectious Disease, 102(3), 115612. -
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses.
Sievers, B. L., Chakraborty, S., Xue, Y., Gelbart, T., Gonzalez, J. C., Cassidy, A. G., … Tan, G. S. (1800). Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses. Science Translational Medicine, eabn7842. -
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.
Chakraborty, S., Gonzalez, J. C., Sievers, B. L., Mallajosyula, V., Chakraborty, S., Dubey, M., … Wang, T. T. (1800). Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Science Translational Medicine, eabm7853. -
Targeted newborn metabolomics: prediction of gestational age from cord blood.
Jasper, E. A., Oltman, S. P., Rogers, E. E., Dagle, J. M., Murray, J. C., Kamya, M., … Ryckman, K. K. (1800). Targeted newborn metabolomics: prediction of gestational age from cord blood. Journal of Perinatology : Official Journal of the California Perinatal Association. -
Gender difference in the incidence of malaria diagnosed at public health facilities in Uganda.
Okiring, J., Epstein, A., Namuganga, J. F., Kamya, E. V., Nabende, I., Nassali, M., … Dorsey, G. (1800). Gender difference in the incidence of malaria diagnosed at public health facilities in Uganda. Malaria Journal, 21(1), 22. -
Long Term Accuracy of SARS-CoV-2 Interferon-? Release Assay and its Application in Household Investigation.
Murugesan, K., Jagannathan, P., Altamirano, J., Maldonado, Y. A., Bonilla, H. F., Jacobson, K. B., … Banaei, N. (2022). Long Term Accuracy of SARS-CoV-2 Interferon-? Release Assay and its Application in Household Investigation. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial.
Holubar, M., Subramanian, A., Purington, N., Hedlin, H., Bunning, B., Walter, K. S., … Maldonado, Y. (2022). Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection.
Natarajan, A., Zlitni, S., Brooks, E. F., Vance, S. E., Dahlen, A., Hedlin, H., … Bhatt, A. S. (2022). Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med (New York, N.Y.). -
DIMINISHED V delta 2+delta gamma T CELL CYTOKINE PRODUCTION AND DEGRANULATION FOLLOWING IN VITRO MALARIA EXPOSURE
Dantzler, K., Klemm, S., Rek, J., Nankya, F., Ssewanyana, I., Kamya, M., … Jagannathan, P. (2021). DIMINISHED V delta 2+delta gamma T CELL CYTOKINE PRODUCTION AND DEGRANULATION FOLLOWING IN VITRO MALARIA EXPOSURE. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
CELLULAR CORRELATES FOR PROTECTION AGAINST MALARIA ACQUIRED ACROSS MULTIPLE PREGNANCIES
Kirosingh, A., De La Parte, L., Ty, M., Kakuru, A., Muhindo, M. K., Thulin, N., … Jagannathan, P. (2021). CELLULAR CORRELATES FOR PROTECTION AGAINST MALARIA ACQUIRED ACROSS MULTIPLE PREGNANCIES. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
PERIPHERAL PLASMODIUM FALCIPARUM INFECTION IN EARLY PREGNANCY IS ASSOCIATED WITH INCREASED MATERNAL MICROCHIMERISM IN THE OFFSPRING
Simon, N., Shallat, J., Houck, J., Jagannathan, P., Prahl, M., Muhindo, M., … Harrington, W. (2021). PERIPHERAL PLASMODIUM FALCIPARUM INFECTION IN EARLY PREGNANCY IS ASSOCIATED WITH INCREASED MATERNAL MICROCHIMERISM IN THE OFFSPRING. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
IDENTIFYING AN OPTIMAL DIHYDROARTEMISININ-PIPERAQUINE DOSING REGIMEN FOR MALARIA PREVENTION IN YOUNG UGANDAN CHILDREN
Wallender, E., Ali, A. M., Hughes, E., Kakuru, A., Jagannathan, P., Muhindo, M. K., … Savic, R. (2021). IDENTIFYING AN OPTIMAL DIHYDROARTEMISININ-PIPERAQUINE DOSING REGIMEN FOR MALARIA PREVENTION IN YOUNG UGANDAN CHILDREN. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
SEX-BASED IMMUNOLOGICAL DIFFERENCES AMONG MALARIA-EXPOSED UGANDANS INCLUDES ABERRANT HEMATOPOIESIS
Nideffer, J., Ty, M., Nayebare, P., Nankya, F., Musinguzi, K., Briggs, J., … Jagannathan, P. (2021). SEX-BASED IMMUNOLOGICAL DIFFERENCES AMONG MALARIA-EXPOSED UGANDANS INCLUDES ABERRANT HEMATOPOIESIS. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
MALARIA-DRIVEN EXPANSION OF MATURE, SHORT-LIVED FUNCTIONAL CD56NEG NK CELLS CORRELATES WITH CLINICAL IMMUNITY TO MALARIA
Ty, M., de la Parte, L., Dantzler, K., van der Ploeg, K., Callaway, P., Tukwasibwe, S., … Jagannathan, P. (2021). MALARIA-DRIVEN EXPANSION OF MATURE, SHORT-LIVED FUNCTIONAL CD56NEG NK CELLS CORRELATES WITH CLINICAL IMMUNITY TO MALARIA. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. AMER SOC TROP MED & HYGIENE. -
Malaria in 2022: Increasing challenges, cautious optimism.
Jagannathan, P., & Kakuru, A. (2022). Malaria in 2022: Increasing challenges, cautious optimism. Nature Communications, 13(1), 2678. -
TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.
van der Ploeg, K., Kirosingh, A. S., Mori, D. A., Chakraborty, S., Hu, Z., Sievers, B. L., … Jagannathan, P. (2022). TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. Cell Reports. Medicine, 100640. -
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Chan, J.-A., Loughland, J. R., de la Parte, L., Okano, S., Ssewanyana, I., Nalubega, M., … Boyle, M. J. (2022). Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children. Nature Communications, 13(1), 4159. -
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study.
Hu, Z., van der Ploeg, K., Chakraborty, S., Arunachalam, P. S., Mori, D. A., Jacobson, K. B., … Jagannathan, P. (2022). Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study. ELife, 11. -
Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19.
Moser, C., Li, J. Z., Eron, J. J., Aga, E., Daar, E. S., Wohl, D. A., … Chew, K. W. (2022). Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19. Open Forum Infectious Diseases, 9(11), ofac618. -
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Ty, M., Sun, S., Callaway, P. C., Rek, J., Press, K. D., van der Ploeg, K., … Jagannathan, P. (2023). Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria. Science Translational Medicine, 15(680), eadd9012. -
Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference.
Walter, K. S., Kim, E., Verma, R., Altamirano, J., Leary, S., Carrington, Y. J., … Andrews, J. R. (2023). Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference. Open Forum Infectious Diseases, 10(2), ofad001. -
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Ivanochko, D., Fabra-García, A., Teelen, K., van de Vegte-Bolmer, M., van Gemert, G.-J. J., Newton, J., … Julien, J.-P. P. (2023). Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230. Immunity, 56(2), 420–432.e7. -
Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.
Fabra-García, A., Hailemariam, S., de Jong, R. M., Janssen, K., Teelen, K., van de Vegte-Bolmer, M., … Jore, M. M. (2023). Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes. Immunity, 56(2), 406–419.e7. -
Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022.
Briggs, J., Takahashi, S., Nayebare, P., Cuu, G., Rek, J., Zedi, M., … Rodriguez-Barraquer, I. (2023). Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022. JAMA Network Open, 6(2), e2255978. -
Can we reduce malaria in pregnancy and improve birth outcomes?
Kakuru, A., & Jagannathan, P. (2023). Can we reduce malaria in pregnancy and improve birth outcomes? Lancet (London, England). -
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection.
Gao, F., Mallajoysula, V., Arunachalam, P. S., van der Ploeg, K., Manohar, M., Röltgen, K., … Davis, M. M. (2023). Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection. Immunity. -
Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine.
Tukwasibwe, S., Mboowa, G., Sserwadda, I., Nankabirwa, J. I., Arinaitwe, E., Ssewanyana, I., … Nakimuli, A. (2023). Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine. Immunogenetics. -
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda.
Mwakibete, L., Takahashi, S., Ahyong, V., Black, A., Rek, J., Ssewanyana, I., … Greenhouse, B. (2023). Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda. PLOS Global Public Health, 3(5), e0001675. -
Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC).
Mohandas, S., Jagannathan, P., Henrich, T. J., Sherif, Z. A., Bime, C., Quinlan, E., … Rehman, J. (2023). Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC). ELife, 12. -
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.
Thaweethai, T., Jolley, S. E., Karlson, E. W., Levitan, E. B., Levy, B., McComsey, G. A., … Zisis, S. (2023). Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA. -
Type I regulatory T cells in malaria: of mice and men Jason Nideffer, Prasanna Jagannathan
Nideffer, J., & Jagannathan, P. (2023). Type I regulatory T cells in malaria: of mice and men Jason Nideffer, Prasanna Jagannathan. JOURNAL OF CLINICAL INVESTIGATION, 133(1). -
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
Horwitz, L. I., Thaweethai, T., Brosnahan, S. B., Cicek, M. S., Fitzgerald, M. L., Goldman, J. D., … Foulkes, A. S. (2023). Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PloS One, 18(6), e0286297. -
The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker.
Natarajan, A., Fremin, B. J., Schmidtke, D. T., Wolfe, M. K., Zlitni, S., Graham, K. E., … Boehm, A. B. (2023). The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker. Applied and Environmental Microbiology, e0058323. -
Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker.
Natarajan, A., Fremin, B. J., Schmidtke, D. T., Wolfe, M. K., Zlitni, S., Graham, K. E., … Boehm, A. B. (2023). Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker. BioRxiv : the Preprint Server for Biology. -
Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria.
Kirosingh, A. S., Delmastro, A., Kakuru, A., van der Ploeg, K., Bhattacharya, S., Press, K. D., … Jagannathan, P. (2023). Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria. EBioMedicine, 95, 104772. -
Sex-Linked Differences in Malaria Risk Across the Lifespan.
Briggs, J., Murray, M., Nideffer, J., & Jagannathan, P. (2023). Sex-Linked Differences in Malaria Risk Across the Lifespan. Current Topics in Microbiology and Immunology, 441, 185–208. -
Safety and efficacy of inhaled interferon-ß1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial.
Jagannathan, P., Chew, K. W., Giganti, M. J., Hughes, M. D., Moser, C., Main, M. J., … Fischer, W. (2023). Safety and efficacy of inhaled interferon-ß1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial. EClinicalMedicine, 65, 102250. -
Atypical B cells consist of subsets with distinct functional profiles.
Reyes, R. A., Batugedara, G., Dutta, P., Reers, A. B., Garza, R., Ssewanyana, I., … Bunnik, E. M. (2023). Atypical B cells consist of subsets with distinct functional profiles. IScience, 26(12), 108496. -
Regulation of fetal tolerance by KIR<SUP>+</SUP> regulatory CD8<SUP>+</SUP> T cells in human pregnancy
Li, J., Li, L., Prunicki, M., Narasimhan, P., Mallajosyula, V., Kirosingh, A., … Davis, M. M. (2023). Regulation of fetal tolerance by KIR+ regulatory CD8+ T cells in human pregnancy. JOURNAL OF IMMUNOLOGY. AMER ASSOC IMMUNOLOGISTS. -
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda.
Kamya, M. R., Nankabirwa, J. I., Arinaitwe, E., Rek, J., Zedi, M., Maiteki-Sebuguzi, C., … Dorsey, G. (2024). Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. MedRxiv : the Preprint Server for Health Sciences. -
Monthly Sulfadoxine-Pyrimethamine During Pregnancy Prevents Febrile Respiratory Illnesses: A Secondary Analysis of a Malaria Chemoprevention Trial in Uganda.
Lee, J. J., Kakuru, A., Jacobson, K. B., Kamya, M. R., Kajubi, R., Ranjit, A., … Roh, M. E. (2024). Monthly Sulfadoxine-Pyrimethamine During Pregnancy Prevents Febrile Respiratory Illnesses: A Secondary Analysis of a Malaria Chemoprevention Trial in Uganda. Open Forum Infectious Diseases, 11(4), ofae143.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
SHC- Infectious Disease Palo Alto, CA
Palo Alto, CAImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Referring Physicians
PHYSICIAN HELPLINE
Phone: 1-866-742-4811
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
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- View referral status
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