Mark Pegram

Medical oncologist, Breast specialist

Susy Yuan-Huey Hung Professor
Bio:   Mark D. Pegram, MD, is the first director of the Breast Cancer Oncology Program at Stanford Women’s Cancer Center. He is also the co-director of Stanford’s Molecular Therapeutics Program. He is a renowned clinician and scholar in breast cancer research and a leader in translational medicine. Dr. Pegram played a major role in developing the drug Herceptin as a treatment for HER2-positive breast cancer, which constitutes about 20 percent of all cases. His laboratory experiments demonstrated that combining Herceptin with chemotherapy effectively killed cancer cells that overproduced the growth factor HER2. Dr. Pegram and others then conducted clinical trials showing that Herceptin improved survival rates and even cured some breast cancer patients. This remains one of the premier examples of bench-to-bedside translational research. Dr. Pegram’s current research efforts include a continued focus on the cancer-associated gene that encodes HER2 and developing new ways to target cancer cells expressing this protein. He is also pursuing strategies to target estrogen receptors, implicated in some 70 percent of all breast cancer cases.
Dr. Pegram earned his undergraduate and medical degrees from the University of North Carolina before joining the faculty of the University of California, Los Angeles. He spent five years at the University of Miami Miller School of Medicine, where he was a Sylvester Chair professor of medicine in the Braman Family Breast Cancer Institute and associate director for clinical research in the University’s Sylvester Comprehensive Cancer Center. He joined the Stanford faculty in 2012.
4.7 out of 5
92 Patient Ratings
8 Patient Comments

Breast Cancer Program

  • 900 Blake Wilbur Drive
  • 1st Floor
  • Palo Alto, CA 94304
  • Phone: 650-498-6004
More Clinic Information » Insurance Coverage » Getting Here » Make An Appointment

Stanford Women's Cancer Center

  • 900 Blake Wilbur Drive
  • 1st Floor
  • Palo Alto, CA 94304
  • Phone: 650-498-6004
More Clinic Information » Insurance Coverage » Getting Here » Make An Appointment

Professional Education

  • Board Certification: Medical Oncology, American Board of Internal Medicine (1993)
  • Board Certification: Internal Medicine, American Board of Internal Medicine (1989)
  • Internship: Univ Of Texas Southwestern (1987) TX
  • Residency: Univ Of Texas Southwestern (1987) TX
  • Fellowship: UCLA - School of Medicine (1993) CA
  • Medical Education: University of North Carolina (1986) NC

Honors & Awards

  • The Celebrity Cruises Award, The Breast Cancer Research Foundation (2013-2014)
  • 2012 Keynote Lecture, American Radium Society 94th Annual Meeting, American Radium Society (29 April 2012)
  • Chair, Department of Defense Breast Cancer Research Program Integration Panel, Congressionally Directed Medical Research Programs, U.S. Army Research and Materiel Command (2012)
  • John G. Kuhn Lecture, Hematology/Oncology Pharmacy Association (21 March 2013)
  • 6th Annual Connie Moskow Memorial Lectureship, Robert H. Lurie Comprehensive Cancer Center of Northwestern University (11 May 2012)
  • Sylvester Outstanding Cancer Research Award, University of Miami Sylvester Comprehensive Cancer Center (13 May 2011)

Administrative Appointments

  • Co-Director, Translational Oncology Research Program @ Stanford (TOP@S), Stanford Cancer Institute (2013 - Present)
  • Director, Stanford Breast Oncology Program, Stanford Cancer Institute (2012 - Present)
  • Associate Director for Clinical Research, Stanford Cancer Institute (2013 - Present)

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

4.8

Friendliness

4.6

Recommended to others

4.7

Explanations

4.7

Listens

4.7

Includes you in decisions

4.8

Clear Communication

4.7

Confidence in your doctor

3.4

Wait times

SHC Patient, May 2015

Dr. Pegram made the final decision about my care.

SHC Patient, Apr 2015

Dr. Pegram saved my life. He recognized a pending heart problem - sent me to emergency where I had a cardiac arrest! He was on the ball 100%

SHC Patient, Apr 2015

Dr. Pegram is very knowledgeable, kind and compassionate. He has given me the confidence to continue to fight my cancer.

SHC Patient, Mar 2015

Dr. Pegram & his staff are always very thorough and take time to listen to my questions & concerns, if any.

SHC Patient, Feb 2015

Didn't have time to answer questions in some cases answered a related question, not the one I asked.

SHC Patient, Nov 2014

Dr. Pegram rocks! He is caring. Very knowledgeable, inspires confidence, astute.

SHC Patient, Aug 2014

Anything negative is far overshadowed by all the GOOD received from Dr. Pegram!!

SHC Patient, May 2014

I come all the way from Petaluma because I feel that I have a better chance of living longer because of Stanford providers.

4.7 out of 5
92 Patient Ratings
8 Patient Comments

SHC Patient, May 2015

Dr. Pegram made the final decision about my care.

SHC Patient, Apr 2015

Dr. Pegram saved my life. He recognized a pending heart problem - sent me to emergency where I had a cardiac arrest! He was on the ball 100%

SHC Patient, Apr 2015

Dr. Pegram is very knowledgeable, kind and compassionate. He has given me the confidence to continue to fight my cancer.

SHC Patient, Mar 2015

Dr. Pegram & his staff are always very thorough and take time to listen to my questions & concerns, if any.

SHC Patient, Feb 2015

Didn't have time to answer questions in some cases answered a related question, not the one I asked.

SHC Patient, Nov 2014

Dr. Pegram rocks! He is caring. Very knowledgeable, inspires confidence, astute.

SHC Patient, Aug 2014

Anything negative is far overshadowed by all the GOOD received from Dr. Pegram!!

SHC Patient, May 2014

I come all the way from Petaluma because I feel that I have a better chance of living longer because of Stanford providers.