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Biography
Dr. Steffner specializes in the evaluation, diagnosis, and treatment of bone and soft tissue tumors in pediatric and adult patients. This includes primary bone and soft tissue sarcomas, locally active conditions such as giant cell tumor, aneurysmal bone cyst, and chondroblastoma, as well as impending and pathologic fractures from metastatic carcinoma, multiple myeloma, and lymphoma. He works closely with the multidisciplinary sarcoma group at the Stanford Cancer Center to provide coordinated, highly specialized treatment strategies.
Research interests include circulating tumor DNA in bone and soft tissue sarcomas, local drug delivery, establishment of a national bone and soft tissue registry, and collaborative clinical studies on imaging and soft tissue management.
Research interests include circulating tumor DNA in bone and soft tissue sarcomas, local drug delivery, establishment of a national bone and soft tissue registry, and collaborative clinical studies on imaging and soft tissue management.
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Professional Summary
Education & Certifications
- Board Certification: American Board of Orthopaedic Surgery, Orthopaedic Surgery (2015)
- Oncology Fellowship, University of Chicago, Chicago IL, Department of Orthopaedic Surgery (2013)
- Trauma Fellowship, University of California-Davis, Sacramento CA, Department of Orthopaedic Surgery (2012)
- Residency, University of Chicago, Chicago IL, Department of Orthopaedic Surgery (2011)
- Doctor of Medicine, Wayne State School of Medicine, Detroit MI, Medicine (2006)
Memberships
- Board Certified, American Board of Orthopaedic Surgery (ABOS) (2015 - Present)
- Fellow, American Academy of Orthopaedic Surgeons (AAOS) (2015 - Present)
- Member, Children’s Oncology Group (COG) (2015 - Present)
- Faculty Member, AO Trauma (2013 - Present)
- Member, Musculoskeletal Tumor Society (MSTS) (2013 - Present)
Publications
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Surgical Intervention of Nonvertebral Osseous Metastasis
Attar, S., Steffner, R. J., Avedian, R., & Hussain, W. M. (2012). Surgical Intervention of Nonvertebral Osseous Metastasis. CANCER CONTROL, 19(2), 113–21. -
Ascorbic acid recycling by cultured beta cells: Effects of increased glucose metabolism
Steffner, R. J., Wu, L., Powers, A., & May, A. M. (2004). Ascorbic acid recycling by cultured beta cells: Effects of increased glucose metabolism. FREE RADICAL BIOLOGY AND MEDICINE, 37(10), 1612–21. -
Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
Wu, L., Nicholson, W., Knobel, S. M., Steffner, R. J., May, J. M., Piston, D. W., & Powers, A. C. (2004). Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(13), 12126–34. -
Aneurysmal Bone Cyst
Steffner, R. J., Avedian, R., & Peabody, T. (2009). Aneurysmal Bone Cyst. American Academy of Orthopaedic Surgeons. Orthopaedic Knowledge Online (OKO). Retrieved from http://www5.aaos.org/oko/description.cfm?topic=ONC013 -
Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment?
Steffner, R. J., Liao, C., Stacy, G., Atanda, A., Attar, S., Avedian, R., & Peabody, T. D. (2011). Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment? Journal of Bone and Joint Surgery. American Volume, 93(21), e1221–9. -
Humeral shaft fractures.
Spiguel, A. R., & Steffner, R. J. (2012). Humeral shaft fractures. Current Reviews in Musculoskeletal Medicine, 5(3), 177–83. -
Emerging Concepts in Upper Extremity Trauma Humeral Shaft Fractures
Steffner, R. J., & Lee, M. A. (2013). Emerging Concepts in Upper Extremity Trauma Humeral Shaft Fractures. ORTHOPEDIC CLINICS OF NORTH AMERICA, 44(1), 21-? -
Conservative management of desmoid tumors is safe and effective.
Park, J. S., Nakache, Y.-P., Katz, J., Boutin, R. D., Steffner, R. J., Monjazeb, A. M., & Canter, R. J. (2016). Conservative management of desmoid tumors is safe and effective. Journal of Surgical Research, 205(1), 115–20. -
Staging of Bone and Soft-tissue Sarcomas.
Steffner, R. J., & Jang, E. S. (2018). Staging of Bone and Soft-tissue Sarcomas. The Journal of the American Academy of Orthopaedic Surgeons. -
LYMPHOMA OF BONE
Steffner, R. J., Jang, E. S., & Danford, N. C. (2018). LYMPHOMA OF BONE. JBJS REVIEWS, 6(1), e1. -
Patient Perceptions Correlate Weakly With Observed Patient Involvement in Decision-making in Orthopaedic Surgery.
Mertz, K., Eppler, S., Yao, J., Amanatullah, D. F., Chou, L., Wood, K. B., … Kamal, R. (2018). Patient Perceptions Correlate Weakly With Observed Patient Involvement in Decision-making in Orthopaedic Surgery. Clinical Orthopaedics and Related Research. -
Case series of sural island flaps used for soft-tissue defects of the distal-third lower extremity
Steffner, R. J., Spiguel, A., Ranieri, J., Suk, M., & Yoo, B. J. (2012). Case series of sural island flaps used for soft-tissue defects of the distal-third lower extremity. JOURNAL OF WOUND CARE, 21(10), 469–75. -
Patient Perceptions Correlate Weakly With Observed Patient Involvement in Decision-making in Orthopaedic Surgery
Mertz, K., Eppler, S., Yao, J., Amanatullah, D. F., Chou, L., Wood, K. B., … Kamal, R. (2018). Patient Perceptions Correlate Weakly With Observed Patient Involvement in Decision-making in Orthopaedic Surgery. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 476(9), 1859–65. -
The Association of Financial Distress With Disability in Orthopaedic Surgery.
Mertz, K., Eppler, S. L., Thomas, K., Alokozai, A., Yao, J., Amanatullah, D. F., … Kamal, R. N. (2019). The Association of Financial Distress With Disability in Orthopaedic Surgery. The Journal of the American Academy of Orthopaedic Surgeons, 27(11), e522–e528. -
Staging of Bone and Soft-tissue Sarcomas
Steffner, R. J., & Jang, E. S. (2018). Staging of Bone and Soft-tissue Sarcomas. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 26(13), E269–E278. -
Motor-sparing high-thoracic erector spinae plane block for proximal humerus surgery and total shoulder arthroplasty surgery: clinical evidence for differential peripheral nerve block?
Ma, W., Sun, L., Ngai, L., Costouros, J. G., Steffner, R., Boublik, J., & Tsui, B. C. (2019). Motor-sparing high-thoracic erector spinae plane block for proximal humerus surgery and total shoulder arthroplasty surgery: clinical evidence for differential peripheral nerve block? Canadian Journal of Anaesthesia = Journal Canadien d'Anesthesie. -
Ferumoxytol Does Not Impact Standardized Uptake Values on PET/MR Scans.
Muehe, A. M., Yerneni, K., Theruvath, A. J., Thakor, A. S., Pribnow, A., Avedian, R., … Daldrup-Link, H. E. (2019). Ferumoxytol Does Not Impact Standardized Uptake Values on PET/MR Scans. Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. -
Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy.
Chen, E. L., Yoo, C. H., Gutkin, P. M., Merriott, D. J., Avedian, R. S., Steffner, R. J., … Hiniker, S. M. (2019). Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy. Pediatric Blood & Cancer, e27967. -
Anti-rotation pins for the compress implant do not increase risk of mechanical failure or impair osseointegration
Campbell, S. T., Steffner, R. J., Finlay, A., Mohler, D. G., & Avedian, R. S. (2019). Anti-rotation pins for the compress implant do not increase risk of mechanical failure or impair osseointegration. ANNALS OF JOINT, 4(8). -
Soft tissue pathology for the radiologist: a tumor board primer with 2020 WHO classification update.
Kuhn, K. J., Cloutier, J. M., Boutin, R. D., Steffner, R., & Riley, G. (2020). Soft tissue pathology for the radiologist: a tumor board primer with 2020 WHO classification update. Skeletal Radiology. -
National Metrics Improved Timeliness of Antibiotic Administration for Open Extremity Fractures.
Shieh, A. K., Lucas, J. F., Shelton, T. J., Wright, A. J., Steffner, R. J., & Wolinsky, P. R. (2020). National Metrics Improved Timeliness of Antibiotic Administration for Open Extremity Fractures. Journal of Orthopaedic Trauma. -
The Importance of Concordance Between Patients and Their Subspecialists
Shah, R. F., Mertz, K., Gil, J. A., Eppler, S. L., Amanatullah, D., Yao, J., … Kamal, R. N. (2020). The Importance of Concordance Between Patients and Their Subspecialists. ORTHOPEDICS, 43(5), 315-+. -
SQ3370-001 IS A MULTI-CENTER OPEN-LABEL PHASE I DOSE-ESCALATION STUDY TO TEST A NOVEL INTRATUMORAL AND SYSTEMIC APPROACH TO TREAT ADVANCED SOLID TUMORS
Bhadri, V., Bui, N., Guminski, A., Oneto, J. M., Murthy, R., Sankhala, K., … Yee, N. (2020). SQ3370-001 IS A MULTI-CENTER OPEN-LABEL PHASE I DOSE-ESCALATION STUDY TO TEST A NOVEL INTRATUMORAL AND SYSTEMIC APPROACH TO TREAT ADVANCED SOLID TUMORS. JOURNAL FOR IMMUNOTHERAPY OF CANCER. BMJ PUBLISHING GROUP. -
Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients.
Theruvath, A. J., Rashidi, A., Nyalakonda, R. R., Avedian, R. S., Steffner, R. J., Spunt, S. L., & Daldrup-Link, H. E. (2021). Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients. Pediatric Radiology. -
Phase 1 trial of SQ3370 in solid tumors.
Guminski, A., Wang, D., Bui, N., Bhadri, V., De Silva, M., Steffner, R., … Subbiah, V. (2021). Phase 1 trial of SQ3370 in solid tumors. CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
MR Imaging of Benign Soft Tissue Tumors: Highlights for the Practicing Radiologist.
Riley, G. M., Kwong, S., Steffner, R., & Boutin, R. D. (2022). MR Imaging of Benign Soft Tissue Tumors: Highlights for the Practicing Radiologist. Radiologic Clinics of North America, 60(2), 263–281. -
Metastatic Pattern of Truncal and Extremity Leiomyosarcoma: Retrospective Analysis of Predictors, Outcomes, and Detection.
Tigchelaar, S. S., Frey, C., Sivaraj, D., Segovia, N. A., Mohler, D. G., Steffner, R. J., & Avedian, R. S. (2022). Metastatic Pattern of Truncal and Extremity Leiomyosarcoma: Retrospective Analysis of Predictors, Outcomes, and Detection. Journal of Personalized Medicine, 12(3). -
Local control outcomes using stereotactic body radiotherapy or surgical resection for metastatic sarcoma.
Gutkin, P. M., von Eyben, R., Chin, A., Donaldson, S. S., Oh, J., Jiang, A., … Hiniker, S. M. (2022). Local control outcomes using stereotactic body radiotherapy or surgical resection for metastatic sarcoma. International Journal of Radiation Oncology, Biology, Physics. -
Health Literacy and Patient Participation in Shared Decision-Making in Orthopedic Surgery
Mertz, K., Eppler, S., Shah, R. F., Yao, J., Steffner, R., Safran, M., … Kamal, R. N. (2022). Health Literacy and Patient Participation in Shared Decision-Making in Orthopedic Surgery. ORTHOPEDICS, 45(4), 227–232. -
Interactions in CSF1-driven Tenosynovial Giant Cell Tumors.
van IJzendoorn, D. G., Matusiak, M., Charville, G. W., Spierenburg, G., Varma, S., Colburg, D. R., … van de Rijn, M. (2022). Interactions in CSF1-driven Tenosynovial Giant Cell Tumors. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Management of Patients with Newly Diagnosed Desmoid Tumors in a First-Line Setting.
Testa, S., Bui, N. Q., Charville, G. W., Avedian, R. S., Steffner, R., Ghanouni, P., … Ganjoo, K. N. (2022). Management of Patients with Newly Diagnosed Desmoid Tumors in a First-Line Setting. Cancers, 14(16). -
Outcomes of Pediatric and Adolescent Patients with Metastatic Sarcoma Treated with Surgical Resection or Stereotactic Ablative Radiation Therapy (SABR)
Oh, J., Gutkin, P., Donaldson, S., Steffner, R., Bruzoni, M., Avedian, R., … Hiniker, S. (2022). Outcomes of Pediatric and Adolescent Patients with Metastatic Sarcoma Treated with Surgical Resection or Stereotactic Ablative Radiation Therapy (SABR). AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS. LIPPINCOTT WILLIAMS & WILKINS. -
Combining Shelf Osteotomy With Proximal Femoral Reconstruction After Oncologic Resection
Zhou, J. Y., Lai, C., Pun, S. Y., Richey, A., Leshikar, H. B., Avedian, R., & Steffner, R. (2023). Combining Shelf Osteotomy With Proximal Femoral Reconstruction After Oncologic Resection. TECHNIQUES IN ORTHOPAEDICS, 38(2), 85–89. -
Assessment of the Interval to Diagnosis in Pediatric Bone Sarcoma.
Kha, S. T., Sharma, J., Kenney, D., Daldrup-Link, H., & Steffner, R. (2023). Assessment of the Interval to Diagnosis in Pediatric Bone Sarcoma. Pediatric Emergency Care. -
Patterns of local recurrence and risk of skin recurrence in soft tissue sarcomas after surgical resection.
Ewongwo, A., Oladipo, E. D., Hui, C., Avedian, R. S., Steffner, R. J., Mohler, D. G., … Moding, E. J. (2023). Patterns of local recurrence and risk of skin recurrence in soft tissue sarcomas after surgical resection. Practical Radiation Oncology. -
OUTCOMES OF PEDIATRIC AND ADOLESCENT PATIENTS WITH METASTATIC SARCOMA TREATED WITH SURGICAL RESECTION OR STEREOTACTIC ABLATIVE RADIATION THERAPY
Oh, J., Gutkin, P., Wang, Y. P., Donaldson, S., Steffner, R., Bruzoni, M., … Hiniker, S. (2023). OUTCOMES OF PEDIATRIC AND ADOLESCENT PATIENTS WITH METASTATIC SARCOMA TREATED WITH SURGICAL RESECTION OR STEREOTACTIC ABLATIVE RADIATION THERAPY. RADIOTHERAPY AND ONCOLOGY. ELSEVIER IRELAND LTD. -
Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy.
Subramanian, A., Nemat-Gorgani, N., Ellis-Caleo, T. J., van IJzendoorn, D. G., Sears, T. J., Somani, A., … Moding, E. J. (2024). Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy. Nature Cancer.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
Orthopaedics and Sports Medicine in Redwood City Redwood City, CA
Redwood City, CA
Orthopaedics and Sports Medicine in Redwood City
450 Broadway Street
Redwood City , CA 94063
Make An Appointment More Clinic Information » Getting Here »Orthopaedic Surgical Oncology Program Redwood City, CA
Redwood City, CA
Orthopaedic Surgical Oncology Program
420 Broadway Street, 1st Floor
Redwood City , CA 94063
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Referring Physicians
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