Scleroderma, also called systemic sclerosis, is a chronic,
degenerative disease that affects the joints, skin, and internal
organs. Scleroderma is also associated with blood vessel abnormalities.
Scleroderma is considered to be a multifactorial condition.
Multifactorial inheritance means that "many factors" are
involved in causing a health problem. The factors are usually both
genetic and environmental, where a combination of genes from both
parents, in addition to unknown environmental factors, produce the
trait or condition. Often one gender (either males or females) is
affected more frequently than the other in multifactorial traits.
Females are affected with scleroderma three to four times more often