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Diagnosing KLS is admittedly a challenge but can be a relief for a family in search of answers. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose KLS is one of exclusion – ruling out other conditions that share symptoms. As a result, potential KLS patients often will undergo a lot of tests in various specialties: for metabolic problems including diabetes, metabolic encephalopathies and hypothyroidism; an MRI to rule out a lesion, tumor or inflammation as the cause; even for multiple sclerosis, which has aspects that can mimic the symptoms of KLS.
The symptoms of KLS – somnolence, hyperphagia and withdrawal – can mimic those of severe depression, sometimes followed by a brief period of high, manic energy that could lead to a misdiagnosis of bipolar disorder. Because of all these variables, all other possibilities need to be ruled out, and the symptoms must still fit with those commonly observed in KLS patients.
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.