Trial ID or NCT#

NCT01188486

Status

NOT RECRUITING

Purpose

Non-small cell lung cancer (NSCLC) is the most deadly cancer in the world. NSCLC annually causes 150,000 deaths in the US and greater than 1 million worldwide. The standard treatment for early stage NSCLC is lobectomy with lymphadenectomy. However, many patients are poor operative candidates or decline surgery. An emerging alternative is Stereotactic Body Radiation Therapy (SBRT). Mounting evidence from Phase I/II studies demonstrates that SBRT offers excellent local control. Most SBRT trials focused on small, peripheral tumors in inoperable patients. Increasingly, clinical trials study SBRT in operable patients, often with larger, central tumors. Using clinical staging, a significant proportion of patients harbor occult nodal metastases when undergoing SBRT to the primary tumor alone. Subgroups of patients carry even higher risk of nodal metastases. These nodal metastases frequently would be removed by surgical intervention. However, SBRT, at present, is only directed at the primary tumor, potentially leading to regional failures in otherwise curable patients. To increase the effectiveness of SBRT for lung tumors, the next logical step is to explore whether the highest risk areas of disease spread can be identified and targeted. Regional failure could be reduced and outcome improved in a significant proportion of patients treated with SBRT if the primary nodal drainage (PND) were identified, targeted and treated in addition to the primary tumor. We propose to conduct a study to determine how well water soluble iodinated contrast material when injected directly into the tumor can be visualized on CT scan and integrated into radiation therapy treatment planning.

Official Title

Pulmonary Interstitial Lymphography in Early Stage Lung Cancer

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No

Investigator(s)

Billy W. Loo, Jr., MD, PhD, DABR
Radiation oncologist, Thoracic specialist
Associate Professor of Radiation Oncology (Radiation Therapy) at the Stanford University Medical Center
Lawrence "Rusty" Hofmann, MD
Interventional radiologist
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Quynh-Thu Le, MD, FACR, FASTRO
Radiation oncologist
Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Otolaryngology-Head and Neck Surgery
Joseph Shrager
Thoracic surgeon, Surgical oncologist
Professor of Cardiothoracic Surgery at the Stanford University Medical Center
Maximilian Diehn, MD, PhD
Radiation oncologist
Assistant Professor of Radiation Oncology (Radiation Therapy)
Ann Leung
Radiologist
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Daniel Sze, MD, PhD
Interventional radiologist
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Nishita Kothary, MD
Interventional radiologist
Associate Professor of Radiology (General Radiology) at the Stanford University Medical Center
Heather Wakelee, MD
Medical oncologist, Thoracic specialist
Professor of Medicine (Oncology) at the Stanford University Medical Center

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CONTACT

CCTO
(650) 498-7061