Trial ID or NCT#

NCT03129061

Status

RECRUITING

Purpose

This is a single-center cross-sectional imaging and correlative biomarker study in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN). Cohort 1 will be patients with unresectable or metastatic SCCHN cancer receiving standard of care (SOC) anti-PD-1 treatment and Cohort 2 will be neoadjuvant study participants who will receive one dose of anti-PD-1 treatment prior to tumor resection or radiation. Blood sampling and tissue biopsies will be collected from both cohorts and both cohorts will undergo two whole body PET(Positron Emission Tomography)/CT(Computed Tomography) imaging with [18F]F-AraG. First scan prior to initiating anti-PD-1 treatment and second scan post initiation of anti-PD-1 treatment in Cohort 1 and prior to tumor resection or radiation in Cohort 2

Official Title

A Pilot Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No

Investigator(s)

John B. Sunwoo
Head and neck surgical oncologist, Head and neck surgeon, Cutaneous oncology specialist, Dermato-oncology specialist, Thyroid and parathyroid surgeon, Surgical oncologist
Professor of Otolaryngology - Head and Neck Surgery and, by courtesy, of Dermatology
Quynh-Thu Le, MD, FACR, FASTRO
Radiation oncologist
Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Otolaryngology-Head and Neck Surgery
Guido A. Davidzon
Clinical Assistant Professor, Radiology - Rad/Nuclear Medicine

Contact us to find out if this trial is right for you.

CONTACT

Nikita Bedi
(650) 723-5957