

Biography
Professional Summary
Education & Certifications
- Residency: Stanford University Dept of Dermatology (2007) CA
- Residency: UCSF Obstetrics and Gynecology (2002) CA
- Medical Education: Harvard Medical School (1999) MA
- Board Certification: American Board of Dermatology, Dermatology (2007)
- MD, Harvard Medical School, Medicine (1999)
Awards & Memberships
- Career Development Award, Dermatology Foundation (2009)
- Fellow, American Academy of Dermatology (2007)
- Leadership Forum, American Academy of Dermatology (2014)
- Research Grant/Award, National Rosacea Society (2014-2015)
- Research Scholar Award, American Skin Association (2013, 2014)
Administrative Appointments
- Director of Adult Dermatological Clinical Trials, Stanford Dermatology (2007 - Present)
- Director of the Advanced Basal Cell Carcinoma Clinic, Stanford Dermatology (2011 - Present)
- Faculty Affiliate, Stanford Longevity Center (2023 - Present)
Publications
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Risk factors associated with striae gravidarum
Chang, A. L. S., Agredano, Y. Z., & Kimball, A. B. (2004). Risk factors associated with striae gravidarum. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 51(6), 881–85. -
A case of argyria after colloidal silver ingestion
Chang, A. L. S., Khosravi, V., & Egbert, B. (2006). A case of argyria after colloidal silver ingestion. JOURNAL OF CUTANEOUS PATHOLOGY, 33(12), 809–11. -
Alefacept for erosive lichen planus: A case series
Chang, A. L. S., Badger, J., Rehmus, W., & Kimball, A. B. (2008). Alefacept for erosive lichen planus: A case series. JOURNAL OF DRUGS IN DERMATOLOGY, 7(4), 379–83. -
A Two-Year, Double-Blind, Randomized Placebo-Controlled Trial of Oral Green Tea Polyphenols on the Long-Term Clinical and Histologic Appearance of Photoaging Skin
Janjua, R., Munoz, C., Gorell, E., Rehmus, W., Egbert, B., Kern, D., & Chang, A. L. S. (2009). A Two-Year, Double-Blind, Randomized Placebo-Controlled Trial of Oral Green Tea Polyphenols on the Long-Term Clinical and Histologic Appearance of Photoaging Skin. DERMATOLOGIC SURGERY, 35(7), 1057–65. -
Association of facial skin aging and vitamin D levels in middle-aged white women
Chang, A. L. S., Fu, T., Amir, O., & Tang, J. Y. (2010). Association of facial skin aging and vitamin D levels in middle-aged white women. CANCER CAUSES & CONTROL, 21(12), 2315–16. -
An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women
Chang, A. L. S., Lingala, B., Chang, T. C., Kern, D. G., Wood, S. M., Toyoda, H., & Knaggs, H. E. (2012). An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women. DERMATOLOGIC SURGERY, 38(3), 462–70. -
A Randomized, Double-Blind, Placebo-Controlled, Pilot Study to Assess the Efficacy and Safety of Clindamycin 1.2% and Tretinoin 0.025% Combination Gel for the Treatment of Acne Rosacea Over 12 Weeks
Chang, A. L. S., Alora-Palli, M., Lima, X. T., Chang, T. C., Cheng, C., Chung, C. M., … Kimball, A. B. (2012). A Randomized, Double-Blind, Placebo-Controlled, Pilot Study to Assess the Efficacy and Safety of Clindamycin 1.2% and Tretinoin 0.025% Combination Gel for the Treatment of Acne Rosacea Over 12 Weeks. JOURNAL OF DRUGS IN DERMATOLOGY, 11(3), 333–39. -
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Sekulic, A., Migden, M. R., Oro, A. E., Dirix, L., Lewis, K. D., Hainsworth, J. D., … Hauschild, A. (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2171–2179. -
Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma
Gomez-Ospina, N., Chang, A. L. S., Qu, K., & Oro, A. E. (2012). Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma. NEW ENGLAND JOURNAL OF MEDICINE, 366(23), 2233–2234. -
Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study
Chang, A. L. S., Bitter, P. H., Qu, K., Lin, M., Rapicavoli, N. A., & Chang, H. Y. (2013). Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(2), 394–402. -
A simple intervention to reinforce awareness of tanning bed use and skin cancer in non-medical skin care professionals in Southern California
Ng, A. T., Chang, A. L. S., Cockburn, M., & Peng, D. H. (2012). A simple intervention to reinforce awareness of tanning bed use and skin cancer in non-medical skin care professionals in Southern California. INTERNATIONAL JOURNAL OF DERMATOLOGY, 51(11), 1307–1312. -
Native American skin offerings mistaken for acne scars in a college undergraduate.
Truong, A., Wong, J. W., & Chang, A. L. S. (2012). Native American skin offerings mistaken for acne scars in a college undergraduate. Archives of Dermatology, 148(10), 1214–15. -
Hedgehog pathway inhibition and the race against tumor evolution
Atwood, S. X., Chang, A. L. S., & Oro, A. E. (2012). Hedgehog pathway inhibition and the race against tumor evolution. JOURNAL OF CELL BIOLOGY, 199(2), 193–97. -
New Onset of Keratoacanthomas After Vismodegib Treatment for Locally Advanced Basal Cell Carcinomas: A Report of 2 Cases
Aasi, S., Silkiss, R., Tang, J. Y., Wysong, A., Liu, A., Epstein, E., … Chang, A. L. S. (2013). New Onset of Keratoacanthomas After Vismodegib Treatment for Locally Advanced Basal Cell Carcinomas: A Report of 2 Cases. JAMA DERMATOLOGY, 149(2), 242–43. -
Markedly improved overall survival in 10 consecutive patients with metastatic basal cell carcinoma.
Danial, C., Lingala, B., Balise, R., Oro, A. E., Reddy, S., Colevas, A., & Chang, A. L. S. (2013). Markedly improved overall survival in 10 consecutive patients with metastatic basal cell carcinoma. British Journal of Dermatology, 169(3), 673–76. -
Geriatric dermatology review: Major changes in skin function in older patients and their contribution to common clinical challenges.
Chang, A. L., Wong, J. W., Endo, J. O., & Norman, R. A. (2013). Geriatric dermatology review: Major changes in skin function in older patients and their contribution to common clinical challenges. Journal of the American Medical Directors Association, 14(10), 724–30. -
Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced Basal cell carcinoma and resistant Basal carcinomas in gorlin syndrome.
Chang, A. L. S., Atwood, S. X., Tartar, D. M., & Oro, A. E. (2013). Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced Basal cell carcinoma and resistant Basal carcinomas in gorlin syndrome. JAMA Dermatology (Chicago, Ill.), 149(5), 639–41. -
A case of Cinderella: erythema dyschromia perstans (ashy dermatosis or dermatosis cinecienta)
A case of Cinderella: erythema dyschromia perstans (ashy dermatosis or dermatosis cinecienta). (2011). SkinMed: Dermatology for the Clinician, 9(1). -
Preventing diabetic skin ulcers in Latinos-- no small feat: development of a Spanish and English survey for fast assessment of lower extremity skin care practices
Preventing diabetic skin ulcers in Latinos-- no small feat: development of a Spanish and English survey for fast assessment of lower extremity skin care practices. (2009). Archives of Dermatology, 145(4). -
Adoption of Western Culture By Californian Asian Americans: Attitudes and Practices Promoting Sun Exposure
Adoption of Western Culture By Californian Asian Americans: Attitudes and Practices Promoting Sun Exposure. (2009). Archives of Dermatology, 145(5). -
Oral contraceptives for acne and sexual practices
Oral contraceptives for acne and sexual practices. (2009). Journal of the American Academy of Dermatology, 60(3). -
Obstetric attending physician characteristics and their impact on vacuum and forceps delivery rates: University of California at San Francisco experience from 1977 to 1999.
Obstetric attending physician characteristics and their impact on vacuum and forceps delivery rates: University of California at San Francisco experience from 1977 to 1999. (2002). Am J Obstet Gynecol, 186(6). -
Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila.
Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. (1996). Proc Natl Acad Sci U S A, 91(7). -
Salpingectomy or proximal tubal occlusion of unilateral hydrosalpinx increases the potential for spontaneous pregnancy.
Salpingectomy or proximal tubal occlusion of unilateral hydrosalpinx increases the potential for spontaneous pregnancy. (2003). Human Reprod, 18(12). -
Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone
Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone. (1996). J Cell Biol., 134(5). -
More Than Just A Coincidence: Herpes Zoster and Acne Rosacea Appearing Together as Wolf?s Isotopic Response in an Asian Female
More Than Just A Coincidence: Herpes Zoster and Acne Rosacea Appearing Together as Wolf?s Isotopic Response in an Asian Female. (2012). International Journal of Case Reports and Images, Feb. -
A randomized double-blind, placebo-controlled pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks
A randomized double-blind, placebo-controlled pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. (2012). Journal of Drugs in Dermatology, 11(3). -
Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers
Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers. (2012). Genome Medicine, 4(2). -
Native American Skin Offerings Mistaken for Acne Scars in a College Undergraduate
Native American Skin Offerings Mistaken for Acne Scars in a College Undergraduate. (2012). Archives of Dermatology, 148(10). -
Initial assessment of tumor regrowth after vismodegib in advanced basal cell carcinoma patients
Initial assessment of tumor regrowth after vismodegib in advanced basal cell carcinoma patients. (2012). Archives of Dermatology, Aug 20(epub). -
New onset of keratoacanthomas after vismodegib for locally advanced basal cell carcinomas: a report of two cases
New onset of keratoacanthomas after vismodegib for locally advanced basal cell carcinomas: a report of two cases. (2013). JAMA Dermatology, 149(2). -
Stratification of highest risk patients with chronic skin ulcers in a Stanford retrospective cohort includes diabetes, need for systemic antibiotics and albumin levels
Stratification of highest risk patients with chronic skin ulcers in a Stanford retrospective cohort includes diabetes, need for systemic antibiotics and albumin levels. (2012). Ulcers, ID7678561. -
Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and additional resistant basal cell carcinomas in a Gorlin's syndrome patient
Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and additional resistant basal cell carcinomas in a Gorlin's syndrome patient. (2013). JAMA Dermatology, 149(5). -
Vismodegib for periocular and orbital basal cell carcinoma
Gill, H., Moscato, E. E., Chang, A. L. S., Soon, S., & Silkiss, R. (2013). Vismodegib for periocular and orbital basal cell carcinoma. JAMA Ophthalmology, 131(12). -
Geriatric Dermatology. Part 2. Risk factors and cutaneous signs of elder mistreatment for the dermatologist
Geriatric Dermatology. Part 2. Risk factors and cutaneous signs of elder mistreatment for the dermatologist. (2013). Journal of the American Academy of Dermatology, 68(4). -
A Little Known But Life Threatening Association of Bullous Pemphigoid and Acquired Hemophilia: Case Report and Review of the Literature
A Little Known But Life Threatening Association of Bullous Pemphigoid and Acquired Hemophilia: Case Report and Review of the Literature. (2012). Journal of Clinical and Experimental Dermatology Research Dx.doi.org/10.4172/2155-9554.S6-003. -
Phase 1 Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
Weiss, G. J., Miller, W. H., Chang, A. L. S., Sharfman, W. H., Ross, R. W., & Rudin, C. M. (2013). Phase 1 Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors. Cancer Clinical Research, Doi:10.1158/1078-0432.CCR-12-3654, 19(10). -
Hedghog pathway inhibitor Vismodegib (GDC-0449) in metastatic basal cell carcinoma
Lim, S. W., Chang, A. S., & Kelly, J. W. (2012). Hedghog pathway inhibitor Vismodegib (GDC-0449) in metastatic basal cell carcinoma. WILEY-BLACKWELL. -
Getting the word out: A fast intervention to educate nonmedical skin care professionals at salons and spas in southern California about tanning bed usage and skin cancer
Ng, A., Chang, A. L., & Peng, D. (2011). Getting the word out: A fast intervention to educate nonmedical skin care professionals at salons and spas in southern California about tanning bed usage and skin cancer. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 64(2), AB78–AB78. -
Not so positive: Optimism and public self-consciousness were not associated with the placebo response in a rosacea trial.
Kardos, M., Kim, G., Chang, A. S., & Kimball, A. B. (2011). Not so positive: Optimism and public self-consciousness were not associated with the placebo response in a rosacea trial. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ,AZ,AZ,AZ,AZ,AZ,AZ: NATURE PUBLISHING GROUP. -
Association of skin aging severity with blood isoprostane levels in healthy middle-aged Japanese women
Chang, T. C., Lingala, B., Kern, D. G., Wood, S. M., Toyoda, H., Knaggs, H., & Chang, A. S. (2011). Association of skin aging severity with blood isoprostane levels in healthy middle-aged Japanese women. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ,AZ,AZ,AZ,AZ,AZ,AZ: NATURE PUBLISHING GROUP. -
Risk factors associated with striae gravidarum
Chang, A. S., Agredano, Y. Z., & Kimball, A. B. (2004). Risk factors associated with striae gravidarum. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 122(3), A60–A60. -
Identification of genes promoting exceptional skin youthfulness
Chang, A. S., Atzmon, G., Bergman, A., Chang, H. Y., & Barzilai, N. (2012). Identification of genes promoting exceptional skin youthfulness. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC,NC,NC,NC,NC,NC,NC: NATURE PUBLISHING GROUP. -
Transcriptional profiling to identify genes controlling human skin aging
Chang, A. L., Kern, D., Knaggs, H., Gierman, H., & Kim, S. (2012). Transcriptional profiling to identify genes controlling human skin aging. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 66(4), AB32–AB32. -
Dramatically improved overall survival and predictors of disease in 17 metastatic basal cell carcinoma patients
Danial, C., Lingala, B., Oro, A. E., & Chang, A. S. (2012). Dramatically improved overall survival and predictors of disease in 17 metastatic basal cell carcinoma patients. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC,NC,NC,NC,NC,NC,NC: NATURE PUBLISHING GROUP. -
Vismodegib as an adjuvant to surgery for basal cell carcinomas
ALLY, M. S., Aasi, S., Chang, A., Teng, C., Anderson, E. M., Bailey, I., … Tang, J. Y. (2013). Vismodegib as an adjuvant to surgery for basal cell carcinomas. Presented at the International Investigative Dermatology Meeting, EDINBURGH,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND,SCOTLAND: NATURE PUBLISHING GROUP. -
Factors affecting sun protection and skin cancer prevention knowledge, attitudes and practices in Asian-Americans living in Northern California
Chang, A. S., Gorell, E. S., Lee, C., & Munoz, C. A. (2008). Factors affecting sun protection and skin cancer prevention knowledge, attitudes and practices in Asian-Americans living in Northern California. Presented at the International Investigative Dermatology Meeting, KYOTO,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN: NATURE PUBLISHING GROUP. -
Initial Clinical Experience Using a Novel Ultraportable Negative Pressure Wound Therapy Device
Fong, K. D., Hu, D., Eichstadt, S. L., Gorell, E., Munoz, C. A., Lorenz, H. P., & Chang, A. L. S. (2010). Initial Clinical Experience Using a Novel Ultraportable Negative Pressure Wound Therapy Device. WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 22(9), 230–36. -
A single-blind pilot study of oral antioxidant supplementation on skin aging parameters and age associated blood metabolites in female smokers
Chang, A. L., Munoz, C., Kern, D., Gorell, E., & Wood, S. (2010). A single-blind pilot study of oral antioxidant supplementation on skin aging parameters and age associated blood metabolites in female smokers. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 62(3), AB19–AB19. -
EXPANDED ACCESS STUDY OF ADVANCED BCC PATIENTS TREATED WITH THE HEDGEHOG-PATHWAY INHIBITOR VISMODEGIB
Weiss, G. J., Oro, A., Chang, A. L. S., Solomon, J. A., Lorusso, P. M., Hamid, O., … Hainsworth, J. D. (2012). EXPANDED ACCESS STUDY OF ADVANCED BCC PATIENTS TREATED WITH THE HEDGEHOG-PATHWAY INHIBITOR VISMODEGIB. Presented at the 37th Congress of the European-Society-for-Medical-Oncology (ESMO), VIENNA,AUSTRIA,AUSTRIA,AUSTRIA,AUSTRIA: OXFORD UNIV PRESS. -
Identification of genes promoting skin youthfulness
Chang, A. L. S., Atzmon, G., Bergman, A., Atwood, S., Brugmann, S., Chang, H. Y., & Barzilai, N. (2014). Identification of genes promoting skin youthfulness. Journal of Investigative Dermatology, 134(3). -
Oral Smoothened Inhibitor for Advanced Basal Cell Carcinoma of the Hand: A Case Report
Zhu, G. A., Chen, A., & Chang, A. L. S. (2014). Oral Smoothened Inhibitor for Advanced Basal Cell Carcinoma of the Hand: A Case Report. HAND, 9(1). -
Markedly improved overall survival in 10 consecutive patients with metastatic basal cell carcinoma
Danial, C., Lingala, B., Balise, R., Oro, A. E., Reddy, S., Colevas, A., & Chang, A. L. S. (2013). Markedly improved overall survival in 10 consecutive patients with metastatic basal cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY, 169(3), 673–76. -
Geriatric dermatology Part I. Geriatric pharmacology for the dermatologist
Endo, J. O., Wong, J. W., Norman, R. A., & Chang, A. L. S. (2013). Geriatric dermatology Part I. Geriatric pharmacology for the dermatologist. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 68(4). -
Advanced basal cell carcinoma: epidemiology and therapeutic innovations
Mohan, S., & Chang, A. L. S. (2014). Advanced basal cell carcinoma: epidemiology and therapeutic innovations. Curr Derm Rep, 3(1). -
Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib
Chang, A. L. S., Solomon, J. A., Hainsworth, J. D., Goldberg, L., McKenna, E., Day, B.-M., … Weiss, G. J. (2014). Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 70(1), 60–69. -
Identification of genes promoting skin youthfulness by genome-wide association study.
Chang, A. L. S., Atzmon, G., Bergman, A., Brugmann, S., Atwood, S. X., Chang, H. Y., & Barzilai, N. (2014). Identification of genes promoting skin youthfulness by genome-wide association study. Journal of Investigative Dermatology, 134(3), 651–57. -
Oral smoothened inhibitor for advanced basal cell carcinoma of the hand: a case report.
Zhu, G. A., Chen, A., & Chang, A. L. S. (2014). Oral smoothened inhibitor for advanced basal cell carcinoma of the hand: a case report. Hand (New York, N.Y.), 9(1), 127–28. -
Patient With Gorlin Syndrome and Metastatic Basal Cell Carcinoma Refractory to Smoothened Inhibitors.
Zhu, G. A., Li, A. S., & Chang, A. L. (2014). Patient With Gorlin Syndrome and Metastatic Basal Cell Carcinoma Refractory to Smoothened Inhibitors. JAMA Dermatology. -
Overall and progression-free survival in metastatic basosquamous cancer: A case series.
Zhu, G. A., Danial, C., Liu, A., Li, S., & Su Chang, A. L. (2014). Overall and progression-free survival in metastatic basosquamous cancer: A case series. Journal of the American Academy of Dermatology, 70(6), 1145–46. -
Low rate of dermatology outpatient visits in Asian-Americans: initial survey study for associated patient-related factors
Lingala, B., Wysong, A., Li, S., Truong, A., Kim, D., & Chang, A. L. S. (2014). Low rate of dermatology outpatient visits in Asian-Americans: initial survey study for associated patient-related factors. BioMed Central Dermatology, 14(13). -
Only Skin Deep: Optimism and Public Self-Consciousness Did Not Associate With the Placebo Response in a Dermatology Clinical Trial
Garshick, M. K., Chang, A. L. S., & Kimball, A. B. (2014). Only Skin Deep: Optimism and Public Self-Consciousness Did Not Associate With the Placebo Response in a Dermatology Clinical Trial. JOURNAL OF DRUGS IN DERMATOLOGY, 13(6), 719–22. -
Precision medicine and precision therapeutics: Hedgehog signaling pathway, basal cell carcinoma and beyond.
Mohan, S. V., & Chang, A. L. S. (2014). Precision medicine and precision therapeutics: Hedgehog signaling pathway, basal cell carcinoma and beyond. Seminars in Cutaneous Medicine and Surgery, 33(2), 68–71. -
Low rate of dermatology outpatient visits in Asian-Americans: an initial survey study for associated patient-related factors.
Lingala, B., Li, S., Wysong, A., Truong, A. K., Kim, D., & Chang, A. L. S. (2014). Low rate of dermatology outpatient visits in Asian-Americans: an initial survey study for associated patient-related factors. BMC Dermatology, 14(1), 13-? -
Three case reports illustrating reversible cutaneous side effects of vismodegib treatment
Kwong, B., Danial, C., Liu, A., Chun, K., & Chang, A. L. S. (2014). Three case reports illustrating reversible cutaneous side effects of vismodegib treatment. Cutis. -
Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor vismodegib (GDC-0449)
Meani, R. E., Lim, S.-W., Chang, A. L. S., & Kelly, J. W. (2014). Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor vismodegib (GDC-0449). AUSTRALASIAN JOURNAL OF DERMATOLOGY, 55(3), 218–221. -
Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations
Chao, C. S., McKnight, K. D., Cox, K. L., Chang, A. L. S., Kim, S. K., & Feldman, B. J. (2015). Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PLOS ONE, DOI: 10.1371/journal.pone.0118449. -
An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma
Ally, M. S., Aasi, S., Wysong, A., Teng, C., Anderson, E., Bailey-Healy, I., … Tang, J. Y. (2014). An investigator-initiated open-label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 71(5), 904–U304. -
Two Different Scenarios of Squamous Cell Carcinoma Within Advanced Basal Cell Carcinomas Cases Illustrating the Importance of Serial Biopsy During Vismodegib Usage
Zhu, G. A., Sundram, U., & Chang, A. L. S. (2014). Two Different Scenarios of Squamous Cell Carcinoma Within Advanced Basal Cell Carcinomas Cases Illustrating the Importance of Serial Biopsy During Vismodegib Usage. JAMA DERMATOLOGY, 150(9), 970–73. -
Patient With Gorlin Syndrome and Metastatic Basal Cell Carcinoma Refractory to Smoothened Inhibitors
Zhu, G. A., Li, A. S., & Chang, A. L. S. (2014). Patient With Gorlin Syndrome and Metastatic Basal Cell Carcinoma Refractory to Smoothened Inhibitors. JAMA DERMATOLOGY, 150(8), 877–79. -
Dermatologic clinical trials: a practical approach
Mohan, S., & Chang, A. L. S. (2014). Dermatologic clinical trials: a practical approach. Clinical dermatology trials 101: a primer for dermatologists (p. 47). Springer. -
Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations.
Chao, C. S., McKnight, K. D., Cox, K. L., Chang, A. L., Kim, S. K., & Feldman, B. J. (2015). Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PloS One, 10(2). -
Randomized, Double-Blind Study of Two Dosages of Sonidegib (LDE225) in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma
Migden, M. R. (2015). Randomized, Double-Blind Study of Two Dosages of Sonidegib (LDE225) in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma. Lancet Oncology, http://dx.doi.org/10.1016/S1470-2045(15)70100-2. -
Pivotal ERIVANCE BCC study: 12-month update of efficacy and safety of vismodegib in advanced basal cell carcinoma
Sekulic, A., Migden, M., Lewis, K., Hainsworth, J., Solomon, J., Yoo, S., … Hauschild, A. (2015). Pivotal ERIVANCE BCC study: 12-month update of efficacy and safety of vismodegib in advanced basal cell carcinoma. Journal of the American Academy of Dermatology, 72(6). -
Overall and Progression-Free Survival of Stage 4 Cutaneous Squamous Cell Carcinoma at a Single Large Referral Center
Zhu, G. A., & Chang, A. L. S. (2015). Overall and Progression-Free Survival of Stage 4 Cutaneous Squamous Cell Carcinoma at a Single Large Referral Center. Journal of the American Academy of Dermatology, 73(1). -
Rolling the genetic dice: neutral and deleterious Smoothened mutations in drug-resistant basal cell carcinoma
Atwood, S. X. (2015). Rolling the genetic dice: neutral and deleterious Smoothened mutations in drug-resistant basal cell carcinoma. Journal of Investigative Dermatology, doi: 10.1038/jid.2015.115. -
Smoothened variants explain the majority of drug resistance in Basal cell carcinoma.
Atwood, S. X., Sarin, K. Y., Whitson, R. J., Li, J. R., Kim, G., Rezaee, M., … Tang, J. Y. (2015). Smoothened variants explain the majority of drug resistance in Basal cell carcinoma. Cancer Cell, 27(3), 342–53. -
Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.
Atwood, S. X., Sarin, K. Y., Li, J. R., Yao, C. Y., Urman, N. M., Chang, A. L. S., … Oro, A. E. (2015). Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. Journal of Investigative Dermatology, 135(8), 2138–41. -
Recent advances in geriatric dermatology
Chang, A. L. S. (2015). (A. L. S. Chang, Ed.)Recent advances in geriatric dermatology. Springer. -
A case report of unresectable cutaneous squamous cell carcinoma responsive to a PD1 inhibitor
Chang, A. L. S., Kim, J., Sullivan-Chang, L., Luciano, R., & Colevas, A. D. (2015). A case report of unresectable cutaneous squamous cell carcinoma responsive to a PD1 inhibitor . JAMA Dermatology, TBD. -
Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC
Sekulic, A., Migden, M. R., Lewis, K., Hainsworth, J. D., Solomon, J. A., Yoo, S., … Hauschild, A. (2015). Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 72(6), 1021-? -
Concurrent Vismodegib and Radiotherapy for Recurrent, Advanced Basal Cell Carcinoma.
Pollom, E. L., Bui, T. T., Chang, A. L. S., Colevas, A. D., & Hara, W. Y. (2015). Concurrent Vismodegib and Radiotherapy for Recurrent, Advanced Basal Cell Carcinoma. JAMA Dermatology, 151(9), 998–1001. -
Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma
Mohan, S. V., & Chang, A. L. S. (2015). Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma. CLINICAL CANCER RESEARCH, 21(12), 2677–83. -
Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study
Chang, A. L. S., Raber, I., Xu, J., Li, R., Spitale, R., Chen, J., … Tung, J. Y. (2015). Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135(6), 1548–55. -
The role of the dermatologist in detecting elder abuse and neglect
Danesh, M. J., & Chang, A. L. S. (2015). The role of the dermatologist in detecting elder abuse and neglect. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 73(2), 285–93. -
A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma
Steenrod, A. W., Smyth, E. N., Bush, E. N., Chang, A. L., Arron, S. T., Helfrich, Y. R., … Coyne, K. S. (2015). A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma. Dermatol Ther, Article DigitalPreview Abstract PMID: 26324194 . -
Mutations in the kinetochore gene KNSTRN in basal cell carcinoma
Jaju, P., Nguyen, C., Mah, A., Atwood, S., Li, J., Zia, A., … Sarin, K. Y. (2015). Mutations in the kinetochore gene KNSTRN in basal cell carcinoma. Journal of Investigative Dermatology, TBD. -
Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma.
Jaju, P. D., Nguyen, C. B., Mah, A. M., Atwood, S. X., Li, J., Zia, A., … Sarin, K. Y. (2015). Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. Journal of Investigative Dermatology, 135(12), 3197–3200. -
Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations.
Chao, C. S., McKnight, K. D., Cox, K. L., Chang, A. L., Kim, S. K., & Feldman, B. J. (2015). Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PloS One, 10(2), e0118449. -
RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.
Zhao, X., Ponomaryov, T., Ornell, K. J., Zhou, P., Dabral, S. K., Pak, E., … Segal, R. A. (2015). RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Research, 75(17), 3623–35. -
Incidental regression of an advanced basal cell carcinoma after ipilimumab exposure for metastatic melanoma
Mohan, S., Kuo, K. Y., & Chang, A. L. S. (2016). Incidental regression of an advanced basal cell carcinoma after ipilimumab exposure for metastatic melanoma. Journal of the American Academy of Dermatology Case Reports. -
A new functional validation assay to measure resistance drivers in patient BCCs
Whitson, R., Atwood, S., SARIN, K., Li, J., Kim, G., Rezaee, M., … Oro, A. (2015). A new functional validation assay to measure resistance drivers in patient BCCs. Presented at the Annual Meeting of the Society-for-Investigative-Dermatology, ATLANTA,GA,GA,GA,GA,GA,GA,GA: NATURE PUBLISHING GROUP. -
Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool
Zhu, G. A., Raber, I., Sakshuwong, S., Li, A., Tan, C., & Chang, A. L. S. (2016). Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool. BioMed Central Dermatology, 1. -
Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma.
Ally, M. S., Ransohoff, K., Sarin, K., Atwood, S. X., Rezaee, M., Bailey-Healy, I., … Colevas, A. D. (2016). Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. JAMA Dermatology, 152(4), 452–56. -
Effects of combined treatment with arsenic trioxide and itraconazole in patients with refractory metastatic basal cell carcinoma
Sarin, K. Y., Ally, M. S., Ransohoff, K. J., Atwood, S. X., & Rezaee, M. (2016). Effects of combined treatment with arsenic trioxide and itraconazole in patients with refractory metastatic basal cell carcinoma. JAMA Dermatology, 1–5. -
Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma
Mohan, S. V., Chang, J., Li, S., Henry, A. S., Wood, D. J., & Chang, A. L. S. (2016). Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma. JAMA DERMATOLOGY, 152(5), 527–32. -
An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib
Danial, C., Sarin, K. Y., Oro, A. E., & Chang, A. L. S. (2016). An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib. CLINICAL CANCER RESEARCH, 22(6), 1325–29. -
Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool.
Zhu, G. A., Raber, I., Sakshuwong, S., Li, S., Li, A. S., Tan, C., & Chang, A. L. S. (2016). Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool. BMC Dermatology, 16(1), 1-? -
A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma.
Steenrod, A. W., Smyth, E. N., Bush, E. N., Chang, A. L. S., Arron, S. T., Helfrich, Y. R., … Coyne, K. S. (2015). A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma. Dermatology and Therapy, 5(3), 183–99. -
Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials
Chang, A. L. S., Arron, S., Migden, M., Solomon, J. A., Yoo, S., Day, B.-M., … Sekulic, A. (2016). Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials. Orphanet Journal of Rare Diseases, 11(120). -
Elder mistreatment training gaps among dermatology resident physicians and opportunity to improve care of a vulnerable population: A cross -sectional study
Danesh, M., Chang, J., Millsop, J. W., Saric, S., Li, S., & Chang, A. L. (2017). Elder mistreatment training gaps among dermatology resident physicians and opportunity to improve care of a vulnerable population: A cross -sectional study . Journal of the American Academy of Dermatology, 76(2). -
Safety and efficacy of vismodegib in patients aged >=65 years with advanced basal cell carcinoma
Chang, A. L. S., Lewis, K. D., Arron, S. T., Migden, M., Solomon, J., Yoo, S., … Sekulic, A. (2016). Safety and efficacy of vismodegib in patients aged >=65 years with advanced basal cell carcinoma. OncoTarget, 76118–24. -
Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC)
Kwon, G. P., Ally, M., Bailey-Healy, I., Oro, A. E., Kim, J., Chang, A. L. S., … Tang, J. Y. (2016). Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC). Journal of the American Academy of Dermatology, 75(1). -
The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.
Dummer, R., Guminski, A., Gutzmer, R., Dirix, L., Lewis, K. D., Combemale, P., … Migden, M. (2016). The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma. Journal of the American Academy Fo Dermatology. -
Follow-up on Programmed Cell Death 1 Inhibitor for Cutaneous Squamous Cell Carcinoma
Tran, D. C., Colevas, A. D., & Chang, A. L. S. (2016). Follow-up on Programmed Cell Death 1 Inhibitor for Cutaneous Squamous Cell Carcinoma . JAMA Dermatology, 153(1). -
Novel Gene expression Profile of Women with Intrinsic Skin Youthfulness By Whole Transcriptome Sequencing
Xu, J., Spitale, R., Guan, L., Flynn, R. A., Torre, E., Li, R., … Chang, A. L. S. (2016). Novel Gene expression Profile of Women with Intrinsic Skin Youthfulness By Whole Transcriptome Sequencing . PLoS ONE , 11(11). -
An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic center
Tran, D. C., Li, S., Henry, S., Wood, D., & Chang, A. L. (2017). An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic center. British Journal of Dermatology, 1749–51. -
Expanding our knowledge of human skin aging
Chang, A. L. S. (2016). Expanding our knowledge of human skin aging . Journal of Investigative Dermatology, 136(5). -
Invited Commentary on "Dermatological disease in the older age group" in British Medical Journal Open 2015 Dec 23;5(12)e009941
Chang, A. L. S. (2016). Invited Commentary on "Dermatological disease in the older age group" in British Medical Journal Open 2015 Dec 23;5(12)e009941. Practice Updates. -
Follow-up on Programmed Cell Death 1 Inhibitor for Cutaneous Squamous Cell Carcinoma.
Tran, D. C., Colevas, A. D., & Chang, A. L. S. (2016). Follow-up on Programmed Cell Death 1 Inhibitor for Cutaneous Squamous Cell Carcinoma. JAMA Dermatology. -
Incidental regression of an advanced basal cell carcinoma after ipilimumab exposure for metastatic melanoma.
Mohan, S. V., Kuo, K. Y., & Chang, A. L. S. (2016). Incidental regression of an advanced basal cell carcinoma after ipilimumab exposure for metastatic melanoma. JAAD Case Reports, 2(1), 13–15. -
Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma
Chang, D. J. (2017). Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma. British Journal of Dermatology, March, e187–e190. -
Reversible cutaneous side effects of vismodegib treatment.
Kwong, B., Danial, C., Liu, A., Chun, K. A., & Chang, A. L. (2017). Reversible cutaneous side effects of vismodegib treatment. Cutis, 99(3), E19–E20. -
Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing
Xu, J., Spitale, R. C., Guan, L., Flynn, R. A., Torre, E. A., Li, R., … Chang, A. L. S. (2016). Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLOS ONE, 11(11). -
Node-positive cutaneous squamous cell carcinoma of the head and neck: Survival, high-risk features, and adjuvant chemoradiotherapy outcomes.
Amoils, M., Lee, C. S., Sunwoo, J., Aasi, S. Z., Hara, W., Kim, J., … Divi, V. (2017). Node-positive cutaneous squamous cell carcinoma of the head and neck: Survival, high-risk features, and adjuvant chemoradiotherapy outcomes. Head & Neck. -
Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing.
Xu, J., Spitale, R. C., Guan, L., Flynn, R. A., Torre, E. A., Li, R., … Chang, A. L. S. (2016). Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PloS One, 11(11). -
Association Between Programmed Death Ligand 1 Expression in Patients With Basal Cell Carcinomas and the Number of Treatment Modalities.
Chang, J., Zhu, G. A., Cheung, C., Li, S., Kim, J., & Chang, A. L. S. (2017). Association Between Programmed Death Ligand 1 Expression in Patients With Basal Cell Carcinomas and the Number of Treatment Modalities. JAMA Dermatology. -
Elder mistreatment training gaps among dermatology resident physicians and opportunity to improve care of a vulnerable population: A cross-sectional study.
Danesh, M., Chang, J., Millsop, J. W., Saric, S., Li, S., & Chang, A. L. S. (2017). Elder mistreatment training gaps among dermatology resident physicians and opportunity to improve care of a vulnerable population: A cross-sectional study. Journal of the American Academy of Dermatology, 76(2), 360–62. -
Evidence-based update on rosacea comorbidities and their common physiologic pathways
Holmes, A., Chien, A., Baldwin, H., Spoendlin, J., & Chang, A. L. S. (2017). Evidence-based update on rosacea comorbidities and their common physiologic pathways. Journal of the American Academy of Dermatology, October, 156–66. -
Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study
Lear, J. T., Migden, M., & Chang, A. L. S. (2017). Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study. J Eur Acad Dermatol Venereol., 372–81. -
Emerging trends in the treatment of advanced basal cell carcinoma
Migden, M., Chang, A. L., Dirix, L., Stratigos, A., & Lear, J. T. (2017). Emerging trends in the treatment of advanced basal cell carcinoma. Cancer Treatment Reviews, 1–10. -
Regionally Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: Survival and High-Risk Features
Amoils, M., Lee, C. S., Sunwoo, J., Aasi, S. Z., Hara, W., Kim, J., … Divi, V. (2016). Regionally Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: Survival and High-Risk Features. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. ELSEVIER SCIENCE INC. -
Identification of metastasis-associated microRNAs in basal cell carcinoma
Chang, J., Zhu, G. A., Li, R., Antes, T., Spitale, R., & Chang, A. L. S. (2016). Identification of metastasis-associated microRNAs in basal cell carcinoma. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
Dermatology resident physician training and readiness to identify and manage elder mistreatment
Chang, J., Danesh, M., Endo, J., Osterberg, L., Millsop, J., Aughenbaugh, W., … Chang, A. L. S. (2016). Dermatology resident physician training and readiness to identify and manage elder mistreatment. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study
Lee, C., Li, S., Tran, D., Kwong, B., & Chang, A. L. S. (2018). Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study. Journal of the American Academy of Dermatology. -
A case of metastatic basal cell carcinoma treated with continuous PD-1 inhibitor exposure even after subsequent initiation of radiotherapy and surgery.
Cannon, J. G., Russell, J. S., Kim, J., & Chang, A. L. (2018). A case of metastatic basal cell carcinoma treated with continuous PD-1 inhibitor exposure even after subsequent initiation of radiotherapy and surgery. JAAD Case Reports, 4(3), 248–50. -
PD-1 blockade with cemiplimab in advanced squamous cell carcinoma
Migden, M. R., Rischin, D., Schmults, C. D., Guminski, A., Hauschild, A., Lewis, K., … Chang, A. L. S. (2018). PD-1 blockade with cemiplimab in advanced squamous cell carcinoma. New England Journal of Medicine. -
Enhancer connectome functionally interrogates GWAS-identified intergenic SNPs associated with inflammatory skin conditions
Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H., & Chang, A. (2018). Enhancer connectome functionally interrogates GWAS-identified intergenic SNPs associated with inflammatory skin conditions. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ELSEVIER SCIENCE INC. -
A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults
Chang, A. L. S., Chen, S. C., Osterberg, L., Brandt, S., von Grote, E. C., & Meckfessel, M. H. (2018). A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults. GERIATRIC NURSING, 39(1), 24–28. -
Levocarnitine for vismodegib-associated muscle spasms: a pilot randomized, double-blind, placebo-controlled, investigator-initiated trial.
Cannon, J. G., Tran, D. C., Li, S., & Chang, A. S. (2018). Levocarnitine for vismodegib-associated muscle spasms: a pilot randomized, double-blind, placebo-controlled, investigator-initiated trial. Journal of the European Academy of Dermatology and Venereology : JEADV. -
Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study.
Min Lee, C. K., Li, S., Tran, D. C., Zhu, G. A., Kim, J., Kwong, B. Y., & Chang, A. L. (2018). Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study. Journal of the American Academy of Dermatology. -
Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility
Cho, H., Kuo, K., Li, S., Bailey-Healy, I., Aasi, S., Chang, A., … Sarin, K. Y. (2018). Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138(5), S28. -
Differences in skin aging characteristics in women of East Asian versus European descent residing in the same geographic location
Guan, L., Zhu, G. A., Li, S., Montana, M., Kern, D., Knaggs, H. E., & Chang, A. (2018). Differences in skin aging characteristics in women of East Asian versus European descent residing in the same geographic location. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138(5), S216. -
Association of tumor response to PD-1/PD-L1 immunotherapy and type of dermatitis that arises after the immunotherapy
Lee, C., Li, S., Tran, D., Zhu, A., Kim, J., Kwong, B., & Chang, A. (2018). Association of tumor response to PD-1/PD-L1 immunotherapy and type of dermatitis that arises after the immunotherapy. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ELSEVIER SCIENCE INC. -
An exploratory open- label, investigator-initiated study to evaluate the efficacy and safety of combination sonidegib and buparlisib for advanced basal cell carcinomas
Tran, D. C., Moffat, A., Brotherton, R., Pague, A., Zhu, G. A., & Chang, A. L. S. (2018). An exploratory open- label, investigator-initiated study to evaluate the efficacy and safety of combination sonidegib and buparlisib for advanced basal cell carcinomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 78(5), 1011–13. -
Adjuvant radiotherapy following resection for non-melanoma skin cancer: A retrospective analysis of recurrence risk at Stanford
Cannon, J. D., Li, S., Hara, W., & Chang, A. (2018). Adjuvant radiotherapy following resection for non-melanoma skin cancer: A retrospective analysis of recurrence risk at Stanford. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138(5), S93. -
Unintended widespread facial autoinoculation of varicella by home microneedling roller device.
Leatham, H., Guan, L., & Chang, A. L. (2018). Unintended widespread facial autoinoculation of varicella by home microneedling roller device. JAAD Case Reports, 4(6), 546–47. -
Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility
Cho, H. G., Kuo, K. Y., Li, S., Bailey, I., Aasi, S., Chang, A. S., … Sarin, K. (2018). Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility. Journal of Clinical Investigation Insight, Accepted. -
PDL1 and CD8 expression in basal cell carcinoma correlates with response to Hedgehog inhibitor therapy
Chang, J., Zhu, G. A., Li, S., Kim, J., & Chang, A. S. (2016). PDL1 and CD8 expression in basal cell carcinoma correlates with response to Hedgehog inhibitor therapy. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ELSEVIER SCIENCE INC. -
Overall and progression-free survival of stage 4 cutaneous squamous cell carcinoma at a single large referral center
Zhu, G. A., & Chang, A. L. S. (2015). Overall and progression-free survival of stage 4 cutaneous squamous cell carcinoma at a single large referral center. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 73(1), 165–66. -
A useable and comprehensive tool to estimate cumulative lifetime ultraviolet exposure
Li, A., Chang, A. L. S., & Zhu, G. A. (2014). A useable and comprehensive tool to estimate cumulative lifetime ultraviolet exposure. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 70(5), AB153. -
Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson's disease
Zafar, F., Valappil, R. A., Kim, S., Johansen, K. K., Chang, A. L. S., Tetrud, J. W., … Schule, B. (2018). Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson's disease. NPJ PARKINSONS DISEASE, 4, 18. -
A case of combination PD-1 inhibitor and intralesional 5-fluorouracil for high-frequency nonmelanoma skin cancers in an immunocompromised patient
Duy Tran, Lee, C., Colevas, A. D., & Chang, A. L. (2018). A case of combination PD-1 inhibitor and intralesional 5-fluorouracil for high-frequency nonmelanoma skin cancers in an immunocompromised patient. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB6. -
An exploratory, open-label, investigator-initiated study to evaluate the efficacy and safety of combination sonidegib and buparlisib for advanced basal cell carcinomas
Duy Tran, Zhu, A., & Chang, A. L. (2018). An exploratory, open-label, investigator-initiated study to evaluate the efficacy and safety of combination sonidegib and buparlisib for advanced basal cell carcinomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB38. -
Retrospective comparison of the clinical effects of programmed death protein 1 inhibitors to treat melanoma versus nonmelanoma skin cancer
Jin, M., Li, S., Duy Tran, Henry, S., Wood, D., & Chang, A. L. (2018). Retrospective comparison of the clinical effects of programmed death protein 1 inhibitors to treat melanoma versus nonmelanoma skin cancer. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB246. -
Levocarnitine for vismodegib-associated muscle spasms: A pilot randomized, double-blind, placebo-controlled, investigator-initiated trial
Chang, A. L., Cannon, J., Tran, D., & Li, S. (2018). Levocarnitine for vismodegib-associated muscle spasms: A pilot randomized, double-blind, placebo-controlled, investigator-initiated trial. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB178. -
Recurrence outcomes for nonmelanoma skin cancer after adjuvant radiation
Cannon, J., Li, S., & Chang, A. L. (2018). Recurrence outcomes for nonmelanoma skin cancer after adjuvant radiation. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB241. -
Differences in skin aging characteristics in women of East Asian versus European descent residing in the same geographic location
Guan, L., Zhu, A., Li, S., Montana, M., Kern, D., Knaggs, H., & Chang, A. L. (2018). Differences in skin aging characteristics in women of East Asian versus European descent residing in the same geographic location. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 79(3), AB108. -
Reaction patterns of dermatitis arising during PD-1/PD-L1 inhibitor therapy and association with tumor response
Lee, C., Li, S., Zhu, A., Kim, J., Duy Tran, Kwong, B., & Chang, A. L. (2018). Reaction patterns of dermatitis arising during PD-1/PD-L1 inhibitor therapy and association with tumor response. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility
Cho, H. G., Kuo, K. Y., Li, S., Bailey, I., Aasi, S., Chang, A. L. S., … Sarin, K. Y. (2018). Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility. JCI INSIGHT, 3(15). -
Pembrolizumab for advanced basal cell carcinoma: an investigator-initiated, proof-of-concept study.
Chang, A. L., Tran, D. C., Cannon, J. G., Li, S., Jeng, M., Patel, R., … Colevas, A. D. (2018). Pembrolizumab for advanced basal cell carcinoma: an investigator-initiated, proof-of-concept study. Journal of the American Academy of Dermatology. -
Response to the Letter to the Editor entitled, "Use of immortal time within survival analysis": JAAD-D-18-01157.
Min Lee, C. K., Li, S., Tran, D. C., Zhu, G. A., Kim, J., Kwong, B. Y., & Chang, A. L. (2018). Response to the Letter to the Editor entitled, "Use of immortal time within survival analysis": JAAD-D-18-01157. Journal of the American Academy of Dermatology. -
??????Initial clinical experience using a novel ultraportable negative pressure wound therapy device.
Fong, K. D., Hu, D., Eichstadt, S. L., Gorell, E., Munoz, C. A., Lorenz, H. P., & Chang, A. L. (2010). ??????Initial clinical experience using a novel ultraportable negative pressure wound therapy device. Wounds : a Compendium of Clinical Research and Practice, 22(9), 230–6. -
Enhancer connectome nominates target genes of inherited risk variants from inflammatory skin disorders.
Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H. Y., & Chang, A. L. (2018). Enhancer connectome nominates target genes of inherited risk variants from inflammatory skin disorders. The Journal of Investigative Dermatology. -
Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma.
Patel, R., & Chang, A. L. (2019). Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma. American Journal of Clinical Dermatology. -
Pathophysiology of basal cell carcinoma and its associated genetic syndromes
Chang, A. L. S. (2019). Pathophysiology of basal cell carcinoma and its associated genetic syndromes. Basal cell carcinoma-- advances in treatment and research. Springer. -
Hyaluronan synthase 2 antisense transcript level associates with human skin youthfulness as identified by transcriptome sequencing
Xu, J., Flynn, R. A., Spitale, R., Torre, E., Li, R., Kern, D. G., … Chang, A. S. (2015). Hyaluronan synthase 2 antisense transcript level associates with human skin youthfulness as identified by transcriptome sequencing. JOURNAL OF INVESTIGATIVE DERMATOLOGY. NATURE PUBLISHING GROUP. -
Rejuvenation of gene expression patterns in aged human skin with broadband light treatment
Chang, A. S., Bitter, P., Qu, K., & Chang, H. Y. (2012). Rejuvenation of gene expression patterns in aged human skin with broadband light treatment. JOURNAL OF INVESTIGATIVE DERMATOLOGY. NATURE PUBLISHING GROUP. -
PD-1 inhibition for cutaneous squamous cell carcinoma: A study of six consecutive cases
Duy Tran, Colevas, A. D., & Chang, A. (2017). PD-1 inhibition for cutaneous squamous cell carcinoma: A study of six consecutive cases. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 76(6), AB193. -
Cross-modal Attribute Transfer for Rescaling 3D Models
Shao, L., Chang, A. X., Su, H., Savva, M., & Guibas, L. (2017). Cross-modal Attribute Transfer for Rescaling 3D Models. PROCEEDINGS 2017 INTERNATIONAL CONFERENCE ON 3D VISION (3DV), 640–48. -
Efficacy and safety of sonidegib in patients (pts) with nevoid basal cell carcinoma syndrome (NBCCS)
Lear, J., Migden, M., Guminski, A., Dirix, L., Chang, A. L. S., Burnett, P., … Dummer, R. (2016). Efficacy and safety of sonidegib in patients (pts) with nevoid basal cell carcinoma syndrome (NBCCS). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 74(5), AB196. -
A randomized, double-blind, placebo-controlled crossover trial of levocarnitine for vismodegib-associated muscle spasms (NCT1893892)
Cannon, J. G. D., Tran, D. C., Li, S., & Chang, A. L. S. (2017). A randomized, double-blind, placebo-controlled crossover trial of levocarnitine for vismodegib-associated muscle spasms (NCT1893892). JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(5), S51. -
Commentary on Development of Basal Cell Carcinoma With Squamous Differentiation During Vismodegib Treatment
Chang, A. L. S. (2017). Commentary on Development of Basal Cell Carcinoma With Squamous Differentiation During Vismodegib Treatment. DERMATOLOGIC SURGERY, 43(7), 991–92. -
An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic center
Duy Tran, Li, S., Henry, S., Wood, D., & Chang, A. (2017). An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic center. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 76(6), AB39. -
Study on the Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma: Not a Case-Control Study Reply
Li, S., & Chang, A. L. S. (2016). Study on the Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma: Not a Case-Control Study Reply. JAMA DERMATOLOGY, 152(10), 1173. -
Sonidegib safety in patients with locally advanced Basal Cell Carcinoma and efficacy based on tumor aggressiveness
Lear, J., Guminski, A., Gutzmer, R., Migden, M., Kudchadkar, R., Lewis, K., … Dummer, R. (2016). Sonidegib safety in patients with locally advanced Basal Cell Carcinoma and efficacy based on tumor aggressiveness. MELANOMA RESEARCH, 26, E72–E73. -
Investigator-assessed efficacy and safety of sonidegib in patients with locally advanced basal cell carcinoma and metastatic basal cell carcinoma: results of the BOLT 30-month analysis
Dummer, R., Migden, M., Guminski, A., Gutzmer, R., Kudchadkar, R., Lewis, K., … Lear, J. (2016). Investigator-assessed efficacy and safety of sonidegib in patients with locally advanced basal cell carcinoma and metastatic basal cell carcinoma: results of the BOLT 30-month analysis. MELANOMA RESEARCH, 26, E3. -
Male gender is a significant risk factor for the development of multiple basal cell cancers
Batra, P., Kuo, K., Chahal, H. S., Rieger, K., Oro, A. E., Chang, A. S., … Sarin, K. (2016). Male gender is a significant risk factor for the development of multiple basal cell cancers. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(8), B5. -
Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials
Chang, A. L. S., Arron, S. T., Migden, M. R., Solomon, J. A., Yoo, S., Day, B.-M., … Sekulic, A. (2016). Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials. ORPHANET JOURNAL OF RARE DISEASES, 11, 120. -
Increased risk of cutaneous squamous cell carcinoma after vismodegib therapy for basal cell carcinoma
Chang, A. S., Mohan, S., Chang, J., Wood, D., Henry, S., & Li, S. (2016). Increased risk of cutaneous squamous cell carcinoma after vismodegib therapy for basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(5), S28. -
Dermatology resident physician training and readiness to identify and manage elder mistreatment
Chang, J., Danesh, M., Hibler, B., Saric, S., Millsop, J., Endo, J., … Chang, A. S. (2016). Dermatology resident physician training and readiness to identify and manage elder mistreatment. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(5), S27. -
Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC)
Kwon, G. P., Ally, M. S., Bailey-Healy, I., Oro, A. E., Kim, J., Chang, A. L., … Tang, J. Y. (2016). Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 75(1), 213–15. -
The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma
Dummer, R., Guminski, A., Gutzmer, R., Dirix, L., Lewis, K. D., Combemale, P., … Migden, M. R. (2016). The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 75(1), 113-+. -
IMPROVEMENT OF SIGNS OF XEROSIS AND PRURITUS IN ELDERLY SUBJECTS USING A SKINCARE REGIMEN FORMULATED WITH FILAGGRIN AND CERAMIDE TECHNOLOGY
Brandt, S., Chang, A. S., & Meckfessel, M. (2015). IMPROVEMENT OF SIGNS OF XEROSIS AND PRURITUS IN ELDERLY SUBJECTS USING A SKINCARE REGIMEN FORMULATED WITH FILAGGRIN AND CERAMIDE TECHNOLOGY. GERONTOLOGIST, 55, 471. -
Expanding Our Understanding of Human Skin Aging
Chang, A. L. S. (2016). Expanding Our Understanding of Human Skin Aging. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(5), 897–99. -
Identification of a unique gene expression profile in older women with youthful skin
Chang, A. L., Spitale, R., Torre, E., Li, R., Kern, D., Knaggs, H., & Xu, J. (2015). Identification of a unique gene expression profile in older women with youthful skin. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 72(5), AB24. -
Dermatology practices: Effects of geographic distribution on health care disparities
Pyles, M., Nkansah-Mahaney, N., Chang, A. S., & Resneck, J. (2015). Dermatology practices: Effects of geographic distribution on health care disparities. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135(8), S3. -
Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial
Migden, M. R., Guminski, A., Gutzmer, R., Dirix, L., Lewis, K. D., Combemale, P., … Dummer, R. (2015). Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial. LANCET ONCOLOGY, 16(6), 716–28. -
Assessment of the genetic basis of rosacea by genome-wide association study
Chang, A. S., Raber, I., Xu, J., Li, R., Spitale, R., Chen, J., … Tung, J. (2015). Assessment of the genetic basis of rosacea by genome-wide association study. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135, S42. -
Combined treatment with arsenic trioxide and itraconazole inhibits the hedgehog pathway in patients with refractory metastatic basal cell carcinoma: results from a pilot trial
Ransohoff, K. J., Ally, M. S., Sarin, K., Atwood, S., Rezaee, M., Bailey, I., … Tang, J. Y. (2015). Combined treatment with arsenic trioxide and itraconazole inhibits the hedgehog pathway in patients with refractory metastatic basal cell carcinoma: results from a pilot trial. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135, S30. -
Lack of resistant SMO mutations and decreased mutational load of Gorlin-associated basal cell cancers explain marked response to smoothened inhibitors
Sarin, K., Rezaee, M., Jaju, P., Chang, A. S., Oro, A., Epstein, E., & Tang, J. Y. (2015). Lack of resistant SMO mutations and decreased mutational load of Gorlin-associated basal cell cancers explain marked response to smoothened inhibitors. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135, S23. -
Rolling the genetic dice: Neutral and deleterious SMO mutations in drug-resistant basal cell carcinoma
Atwood, S., Sarin, K., Li, J., Yao, C., Urman, N. M., Chang, A. S., … Oro, A. (2015). Rolling the genetic dice: Neutral and deleterious SMO mutations in drug-resistant basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135, S21. -
Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor Vismodegib (GDC-0449)
Meani, R. E., Lim, S. W., Chang, A. S., & Kelly, J. W. (2015). Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor Vismodegib (GDC-0449). AUSTRALASIAN JOURNAL OF DERMATOLOGY, 56, 53. -
Role of the fibronectin synergy site in modulating integrin recruitment and molecular-scale force generation
Chang, A. C., Mekhdjian, A. H., Morimatsu, M., & Dunn, A. R. (2014). Role of the fibronectin synergy site in modulating integrin recruitment and molecular-scale force generation. MOLECULAR BIOLOGY OF THE CELL, 25. -
Combined treatment with arsenic trioxide and itraconazole inhibits the Hedgehog pathway in patients with refractory metastatic basal cell carcinoma: Results from a pilot trial
Rezaee, M., Ally, M. S., Sarin, K., Atwood, S., Chang, A. S., Oro, A., … Tang, J. Y. (2014). Combined treatment with arsenic trioxide and itraconazole inhibits the Hedgehog pathway in patients with refractory metastatic basal cell carcinoma: Results from a pilot trial. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134(8), S2. -
A phase I study of IPI-926, a novel hedgehog pathway inhibitor, in patients (pts) with advanced or metastatic solid tumors.
Rudin, C. M., Jimeno, A., Miller, W. H., Eigl, B. J., Gettinger, S. N., Chang, A. L. S., … Weiss, G. J. (2011). A phase I study of IPI-926, a novel hedgehog pathway inhibitor, in patients (pts) with advanced or metastatic solid tumors. JOURNAL OF CLINICAL ONCOLOGY, 29(15). -
Identification of unique gene expression profiles in older women with youthful appearing skin
Spitale, R., Li, R., Torre, E., Kern, D. G., Knaggs, H., & Chang, A. S. (2014). Identification of unique gene expression profiles in older women with youthful appearing skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134, S135. -
Open-label pilot study of LDE225 in advanced basal cell carcinoma patients who have been treated previously with a non-LDE225 Smoothened inhibitor
Chang, A. S., & Oro, A. (2014). Open-label pilot study of LDE225 in advanced basal cell carcinoma patients who have been treated previously with a non-LDE225 Smoothened inhibitor. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134, S101. -
Unexpected complexity in smoothened variants associated with drug resistant basal cell carcinoma
Sarin, K., Atwood, S., Li, J., Chang, A. S., Oro, A., & Tang, J. (2014). Unexpected complexity in smoothened variants associated with drug resistant basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134, S36. -
Vismodegib for Periocular and Orbital Basal Cell Carcinoma
Gill, H. S., Moscato, E. E., Chang, A. L. S., Soon, S., & Silkiss, R. Z. (2013). Vismodegib for Periocular and Orbital Basal Cell Carcinoma. JAMA OPHTHALMOLOGY, 131(12), 1591–94. -
High incidence of striae distensae in pediatric adolescent patients on high dose corticosteroids for treatment of rheumatic disease and effect on adherence to prescribed regimen
Washington, N. T., & Chang, A. S. (2013). High incidence of striae distensae in pediatric adolescent patients on high dose corticosteroids for treatment of rheumatic disease and effect on adherence to prescribed regimen. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133, S98. -
Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma
Chang, A. L. S., & Oro, A. E. (2012). Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma. ARCHIVES OF DERMATOLOGY, 148(11), 1324–25. -
Efficacy and safety of vismodegib in advanced basal cell carcinoma
Chang, A., Sekulic, A., Migden, M. R., Hauschild, A., Lewis, K., Hainsworth, J. D., … Oro, A. E. (2012). Efficacy and safety of vismodegib in advanced basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, S93. -
SMO inhibitor effectiveness in a patient with a SHH locus translocation causing holoprosencephaly and basal cell carcinomas
Gomez-Ospina, N., Bangs, C. D., Qu, K., Chang, A. L., & Oro, A. E. (2012). SMO inhibitor effectiveness in a patient with a SHH locus translocation causing holoprosencephaly and basal cell carcinomas. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, S28. -
Facial skin aging and association with blood markers of oxidative stress
Chang, A. L., Morre, D. J., Kern, D., Morre, D., & Wood, S. M. (2011). Facial skin aging and association with blood markers of oxidative stress. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 64(2), AB21. -
Association of facial skin aging and vitamin D levels in healthy middle-aged white women
Chang, A., Tang, J., Amir, O., & Fu, T. (2011). Association of facial skin aging and vitamin D levels in healthy middle-aged white women. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 64(2), AB2. -
A PHASE 1 STUDY OF IPI-926, AN INHIBITOR OF THE HEDGEHOG PATHWAY, IN PATIENTS (PTS) WITH ADVANCED OR METASTATIC SOLID TUMORS
Rudin, C. M., Weiss, G. J., Chang, A., Gettinger, S., Miller, W. H., Eigl, B., … Jimeno, A. (2010). A PHASE 1 STUDY OF IPI-926, AN INHIBITOR OF THE HEDGEHOG PATHWAY, IN PATIENTS (PTS) WITH ADVANCED OR METASTATIC SOLID TUMORS. ANNALS OF ONCOLOGY, 21, 164. -
Preventing Diabetic Skin Ulcers in Latinos-No Small Feat: Development of a Spanish and English Survey for Fast Assessment of Lower Extremity Skin Care Practices
Munoz, C. A., & Chang, A. L. S. (2009). Preventing Diabetic Skin Ulcers in Latinos-No Small Feat: Development of a Spanish and English Survey for Fast Assessment of Lower Extremity Skin Care Practices. ARCHIVES OF DERMATOLOGY, 145(4), 486–88. -
A 2-year, double-blind, randomized, placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin
Chang, A. L., Egbert, B., Munoz, C., Janjua, R., & Rehmus, W. (2009). A 2-year, double-blind, randomized, placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 60(3), AB29. -
Oral contraceptives for acne and sexual practices
Abuabara, K., & Chang, A. L. S. (2009). Oral contraceptives for acne and sexual practices. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 60(3), 515–16. -
PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma.
Migden, M. R., Rischin, D., Schmults, C. D., Guminski, A., Hauschild, A., Lewis, K. D., … Fury, M. G. (2018). PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma. The New England Journal of Medicine. -
Emerging trends in the treatment of advanced basal cell carcinoma.
Migden, M. R., Chang, A. L., Dirix, L., Stratigos, A. J., & Lear, J. T. (2018). Emerging trends in the treatment of advanced basal cell carcinoma. Cancer Treatment Reviews, 64, 1–10. -
Evidence-based update on rosacea comorbidities and their common physiologic pathways.
Holmes, A. D., Spoendlin, J., Chien, A. L., Baldwin, H., & Chang, A. L. (2018). Evidence-based update on rosacea comorbidities and their common physiologic pathways. Journal of the American Academy of Dermatology, 78(1), 156–166. -
Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.
Lear, J. T., Migden, M. R., Lewis, K. D., Chang, A. L., Guminski, A., Gutzmer, R., … Dummer, R. (2018). Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study. Journal of the European Academy of Dermatology and Venereology : JEADV, 32(3), 372–381. -
Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma.
Chang, J., Tran, D. C., Zhu, G. A., Li, R., Whitson, R., Kim, Y. H., … Chang, A. L. (2017). Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma. The British Journal of Dermatology, 177(5), e187–e190. -
An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic centre.
Tran, D. C., Li, S., Henry, S., Wood, D. J., & Chang, A. L. (2017). An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic centre. The British Journal of Dermatology, 177(6), 1749–1751. -
Safety and efficacy of vismodegib in patients aged =65 years with advanced basal cell carcinoma.
Chang, A. L., Lewis, K. D., Arron, S. T., Migden, M. R., Solomon, J. A., Yoo, S., … Sekulic, A. (2016). Safety and efficacy of vismodegib in patients aged =65 years with advanced basal cell carcinoma. Oncotarget, 7(46), 76118–76124. -
The role of the dermatologist in detecting elder abuse and neglect.
Danesh, M. J., & Chang, A. L. (2015). The role of the dermatologist in detecting elder abuse and neglect. Journal of the American Academy of Dermatology, 73(2), 285–93. -
Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma.
Mohan, S. V., & Chang, A. L. (2015). Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 21(12), 2677–83. -
Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations.
Mohan, S. V., & Chang, A. L. (2014). Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations. Current Dermatology Reports, 3, 40–45. -
Reply to: "Use of immortal time within survival analysis"
Lee, C. K. M., Li, S., Duy Cong Tran, Zhu, G. A., Kim, J., Kwong, B. Y., & Chang, A. L. S. (2019). Reply to: "Use of immortal time within survival analysis". JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 80(1), E19–E20. -
Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders
Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H. Y., & Chang, A. L. S. (2019). Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(3), 605–14. -
Interim analysis of phase 2 results for Cemiplimab, a human monoclonal antibody to programmed death-1 (PD-1), in patients with locally advanced cutaneous squamous cell carcinoma
Migden, M. R., Berking, C., Chang, A. L. S., Eigentler, T. K., Hauschild, A., Hernandez-Aya, L., … Fury, M. G. (2019). Interim analysis of phase 2 results for Cemiplimab, a human monoclonal antibody to programmed death-1 (PD-1), in patients with locally advanced cutaneous squamous cell carcinoma. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 17, 161–62. -
Pembrolizumab with or without vismodegib for advanced basal cell carcinoma: An investigator-initiated, proof-of-concept study
Chang, A., Tran, D. C., Cannon, J., Li, S., Jeng, M., Rieger, K., … Colevas, A. (2019). Pembrolizumab with or without vismodegib for advanced basal cell carcinoma: An investigator-initiated, proof-of-concept study. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(5), S92. -
Alterations of gene expression in papulopustular rosacea by whole transcriptome analysis
Shih, Y., Xu, J., Kumar, A., Li, R., & Chang, A. (2019). Alterations of gene expression in papulopustular rosacea by whole transcriptome analysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(5), S170. -
Exploratory study to examine the gene expression effects of topical retinol on aging-related pathways in individuals of East Asian descent
Guan, L., Zhao, L., Xu, J., Li, R., Kern, D., Knaggs, H., & Chang, A. (2019). Exploratory study to examine the gene expression effects of topical retinol on aging-related pathways in individuals of East Asian descent. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(5), S117. -
Pembrolizumab for advanced basal cell carcinoma: An investigator-initiated, proof-of-concept study
Chang, A. L. S., Tran, D. C., Cannon, J. G. D., Li, S., Jeng, M., Patel, R., … Colevas, A. D. (2019). Pembrolizumab for advanced basal cell carcinoma: An investigator-initiated, proof-of-concept study. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 80(2), 564–66. -
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma
Chiang, A., Tan, C. Z., Kuonen, F., Hodgkinson, L. M., Chiang, F., Cho, R. J., … Sarin, K. Y. (2019). Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma. Journal of Investigative Dermatology. -
Low rate of dermatology outpatient visits in Asian-Americans: an initial survey study for associated patient-related factors
Lingala, B., Li, S., Wysong, A., Truong, A. K., Kim, D., & Chang, A. L. S. (2014). Low rate of dermatology outpatient visits in Asian-Americans: an initial survey study for associated patient-related factors. BMC DERMATOLOGY, 14. -
Clonal replacement of tumor-specific T cells following PD-1 blockade.
Yost, K. E., Satpathy, A. T., Wells, D. K., Qi, Y., Wang, C., Kageyama, R., … Chang, H. Y. (2019). Clonal replacement of tumor-specific T cells following PD-1 blockade. Nature Medicine. -
Levocarnitine for vismodegib-associated muscle spasms: a pilot randomized, double-blind, placebo-controlled, investigator-initiated trial
Cannon, J. G. D., Tran, D. C., Li, S., & Chang, A. S. (2018). Levocarnitine for vismodegib-associated muscle spasms: a pilot randomized, double-blind, placebo-controlled, investigator-initiated trial. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 32(7), E298–E299. -
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion.
Satpathy, A. T., Granja, J. M., Yost, K. E., Qi, Y., Meschi, F., McDermott, G. P., … Chang, H. Y. (2019). Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nature Biotechnology, 37(8), 925–36. -
Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in a Partial Response Despite Continuous Vismodegib Treatment
Nayyar, P. M., Chang, A. L. S., Sarin, K., & Ratner, D. (2019). Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in a Partial Response Despite Continuous Vismodegib Treatment. DERMATOLOGIC SURGERY, 45(4), 608–10. -
Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma
Patel, R., & Chang, A. L. S. (2019). Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 20(4), 477–82. -
Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficacy between individuals and could affect wound healing
Mahmoudi, S., Mancini, E., Moore, A., Jahanbani, F., Hebstreit, K., Srinavasan, R., … Brunet, A. (2019). Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficacy between individuals and could affect wound healing. Nature, Accepted. -
An exploratory open label phase 1b study of secukinumab in patients with moderate to severe papulopustular rosacea
Kumar, A., Chiou, A., Shih, Y., Li, S., & Chang, A. (2019). An exploratory open label phase 1b study of secukinumab in patients with moderate to severe papulopustular rosacea. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(9), B15. -
Quantitative analysis of differentially expressed proteins in papulopustular rosacea
Harden, J., Shih, Y., Rajendran, D., Hofland, H., & Chang, A. (2019). Quantitative analysis of differentially expressed proteins in papulopustular rosacea. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(9), B25. -
A phase 1b, open-label, investigator-initiated, proof-of-concept study of pembrolizumab for advanced basal cell carcinomas
Chang, A., Duy Tran, Cannon, J., Li, S., Jeng, M., Rieger, K., … Colevas, D. (2019). A phase 1b, open-label, investigator-initiated, proof-of-concept study of pembrolizumab for advanced basal cell carcinomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 81(4), AB8. -
Exploratory study to examine the gene expression effects of retinol on aging-related molecular pathways in individuals of East Asian descent
Guan, L., Zhao, L., Xu, J., Li, R., Kern, D., Knaggs, H., & Chang, A. L. S. (2019). Exploratory study to examine the gene expression effects of retinol on aging-related molecular pathways in individuals of East Asian descent. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 81(4), AB64. -
Alterations of immune and keratinization gene expression in papulopustular rosacea by whole transcriptome analysis
Shih, Y., Xu, J., Kumar, A., & Chang, A. L. S. (2019). Alterations of immune and keratinization gene expression in papulopustular rosacea by whole transcriptome analysis. Journal of Investigative Dermatology , Accepted(TBD). -
Long term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2, randomised, double-blind BOLT study
Dummer, R., Guminski, A., Gutzmer, R., Lear, J., Lewis, K., Chang, A. L. S., … Migden, M. (2019). Long term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2, randomised, double-blind BOLT study . British Journal of Dermatology, Accepted(TBD). -
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma
Chiang, A., Tan, C., Kuonen, F., Hodgkinson, L., Chiang, F., Cho, R., … Sarin, K. (2019). Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(9), S295. -
Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2 randomised, double-blind BOLT study.
Dummer, R., Guminksi, A., Gutzmer, R., Lear, J. T., Lewis, K. D., Chang, A. L., … Migden, M. R. (2019). Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2 randomised, double-blind BOLT study. The British Journal of Dermatology. -
Phase 2 study of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with metastatic cutaneous squamous cell carcinoma (mCSCC; Group 1): 12-month follow-up.
Guminski, A. D., Lim, A. M. L., Khushalani, N. I., Schmults, C. D., Hernandez-Aya, L. F., Modi, B., … Rischin, D. (2019). Phase 2 study of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with metastatic cutaneous squamous cell carcinoma (mCSCC; Group 1): 12-month follow-up. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Primary analysis of phase 2 results of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with locally advanced cutaneous squamous cell carcinoma (IaCSCC).
Migden, M. R., Khushalani, N. I., Chang, A. L. S., Rischin, D., Schmults, C. D., Hernandez-Aya, L. F., … Lewis, K. D. (2019). Primary analysis of phase 2 results of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with locally advanced cutaneous squamous cell carcinoma (IaCSCC). JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
KEYNOTE-630: Phase 3 study of adjuvant pembrolizumab versus placebo in patients with high risk, locally advanced cutaneous squamous cell carcinoma.
Geiger, J. L., Daniels, G. A., Cohen, E. E. W., Ge, J. Y., Gumuscu, B., Swaby, R. F., & Chang, A. L. S. (2019). KEYNOTE-630: Phase 3 study of adjuvant pembrolizumab versus placebo in patients with high risk, locally advanced cutaneous squamous cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY, 37(15). -
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Mahmoudi, S., Mancini, E., Xu, L., Moore, A., Jahanbani, F., Hebestreit, K., … Brunet, A. (2019). Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature, 574(7779), 553–58. -
Incidence of Perineural Invasion with Hedgehog Pathway Inhibitors in Orbital and Periorbital Basal Cell Carcinoma
Chandramohan, A., Nair, A. A., Chang, A., & Kossler, A. L. (2019). Incidence of Perineural Invasion with Hedgehog Pathway Inhibitors in Orbital and Periorbital Basal Cell Carcinoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9). -
Clonal replacement of tumor-specific T cells following PD-1 blockade. Nature Medicine 2019. 25(8):1251-9.
Yost, K. E., Satpathy, A., Wells, D. K., Qi, Y., Wang, C., Kageyama, R., … Chang, H. Y. (2019). Clonal replacement of tumor-specific T cells following PD-1 blockade. Nature Medicine 2019. 25(8):1251-9. Nature Medicine, 25(8). -
Phase II study of 2 dosing regimens of cemiplimab, a human monoclonal anti-PD-1, in metastatic cutaneous squamous cell carcinoma (mCSCC)
Rischin, D., Lim, A. M., Schmults, C. D., Khushalani, N. I., Hughes, B. G., Schadendorf, D., … Guminski, A. (2019). Phase II study of 2 dosing regimens of cemiplimab, a human monoclonal anti-PD-1, in metastatic cutaneous squamous cell carcinoma (mCSCC). ANNALS OF ONCOLOGY, 30. -
Alterations of Immune and Keratinization Gene Expression in Papulopustular Rosacea by Whole Transcriptome Analysis.
Shih, Y.-H., Xu, J., Kumar, A., Li, R., & Chang, A. L. (2019). Alterations of Immune and Keratinization Gene Expression in Papulopustular Rosacea by Whole Transcriptome Analysis. The Journal of Investigative Dermatology. -
KEYNOTE-630: phase 3 study of adjuvant pembrolizumab versus placebo in patients with high-risk, locally advanced cutaneous squamous cell carcinoma
Geiger, J., Daniels, G., Cohen, E., Ge, J. Y., Gumuscu, B., Swaby, R., & Chang, A. L. (2019). KEYNOTE-630: phase 3 study of adjuvant pembrolizumab versus placebo in patients with high-risk, locally advanced cutaneous squamous cell carcinoma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 7. -
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial.
Migden, M. R., Khushalani, N. I., Chang, A. L., Lewis, K. D., Schmults, C. D., Hernandez-Aya, L., … Rischin, D. (2020). Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial. The Lancet. Oncology. -
Impact of prior lines of systemic therapy (PST) on the efficacy of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with advanced cutaneous squamous cell carcinoma (CSCC)
Rischin, D., Khushalani, N. I., Schmults, C. D., Guminski, A., Chang, A. L. S., Lewis, K. D., … Migden, M. R. (2019). Impact of prior lines of systemic therapy (PST) on the efficacy of cemiplimab, a human monoclonal anti-PD-1, in patients (pts) with advanced cutaneous squamous cell carcinoma (CSCC). ANNALS OF ONCOLOGY, 30. -
A PHASE 2, MULTI-Center, PLACEBO-CONTROLLED STUDY OF Single dose Squaric Acid Dibutyl Ester (sadbe) to reduce frequency of outbreaks IN SUBJECTS WITH RECURRENT HERPES LABIALIS.
Chang, A. L., Honari, G., Guan, L., Zhao, L., Palli, M. A., Horn, T. D., … McTavish, H. (2020). A PHASE 2, MULTI-Center, PLACEBO-CONTROLLED STUDY OF Single dose Squaric Acid Dibutyl Ester (sadbe) to reduce frequency of outbreaks IN SUBJECTS WITH RECURRENT HERPES LABIALIS. Journal of the American Academy of Dermatology. -
An exploratory, open-label, investigator-initiated study of interleukin-17A (IL-17A) blockade in patients with moderate to severe papulopustular rosacea.
Kumar, A. M., Chiou, A. S., Shih, Y. H., Li, S., & Chang, A. L. (2020). An exploratory, open-label, investigator-initiated study of interleukin-17A (IL-17A) blockade in patients with moderate to severe papulopustular rosacea. The British Journal of Dermatology. -
Primary analysis of phase 2 results for cemiplimab, a human monoclonal anti-PD-1, in patients with metastatic cutaneous squamous cell carcinoma (mCSCC)
Rischin, D., Migden, M. R., Chang, A., Chung, C. H., Dunn, L., Guminski, A., … Fury, M. G. (2018). Primary analysis of phase 2 results for cemiplimab, a human monoclonal anti-PD-1, in patients with metastatic cutaneous squamous cell carcinoma (mCSCC). JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing.
Rischin, D., Migden, M. R., Lim, A. M., Schmults, C. D., Khushalani, N. I., Hughes, B. G., … Guminski, A. (2020). Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing. Journal for Immunotherapy of Cancer, 8(1). -
IL-1 beta is a potential central mediator to Papulopustular Rosacea pathology as determined by paired transcriptomic and proteomic analysis
Harden, J., Shih, Y., Rajendran, D., Xu, J., Li, R., Hofland, H., & Chang, A. L. (2020). IL-1 beta is a potential central mediator to Papulopustular Rosacea pathology as determined by paired transcriptomic and proteomic analysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 140(7), S114. -
In-progress validation of candidate rosacea genes by targeted interrogation of alleles and assessment of rosacea comorbidities
Kumar, A., Shih, Y., Chiou, A., Li, S., & Chang, A. L. (2020). In-progress validation of candidate rosacea genes by targeted interrogation of alleles and assessment of rosacea comorbidities. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 140(7), S33. -
Metastatic cutaneous squamous cell carcinoma responsive to cemiplimab in a patient with multiple myeloma.
Marukian, N. V., Lin, J. Q., Colevas, A. D., Coutre, S., & Chang, A. L. (2020). Metastatic cutaneous squamous cell carcinoma responsive to cemiplimab in a patient with multiple myeloma. JAAD Case Reports, 6(9), 819–21. -
Paired Transcriptomic and Proteomic Analysis Implicates IL-1ß in the Pathogenesis of Papulopustular Rosacea Explants.
Harden, J. L., Shih, Y.-H. H., Xu, J., Li, R., Rajendran, D., Hofland, H., & Chang, A. L. (2020). Paired Transcriptomic and Proteomic Analysis Implicates IL-1ß in the Pathogenesis of Papulopustular Rosacea Explants. The Journal of Investigative Dermatology. -
Phase II study of cemiplimab in patients (pts) with advanced cutaneous squamous cell carcinoma (CSCC): Longer follow-up.
Rischin, D., Khushalani, N. I., Schmults, C. D., Guminski, A. D., Chang, A. L. S., Lewis, K. D., … Migden, M. R. (2020). Phase II study of cemiplimab in patients (pts) with advanced cutaneous squamous cell carcinoma (CSCC): Longer follow-up. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Health-related quality of life (HRQL) in patients with advanced cutaneous squamous cell carcinoma (CSCC) treated with cemiplimab: Post hoc exploratory analyses of a phase II clinical trial.
Migden, M. R., Rischin, D., Sasane, M., Mastey, V., Pavlick, A., Schmults, C. D., … Chen, C.-I. (2020). Health-related quality of life (HRQL) in patients with advanced cutaneous squamous cell carcinoma (CSCC) treated with cemiplimab: Post hoc exploratory analyses of a phase II clinical trial. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Primary analysis of phase II results for cemiplimab in patients (pts) with locally advanced basal cell carcinoma (laBCC) who progress on or are intolerant to hedgehog inhibitors (HHIs)
Stratigos, A. J., Sekulic, A., Peris, K., Bechter, O., Dutriaux, C., Kaatz, M., … Fury, M. G. (2020). Primary analysis of phase II results for cemiplimab in patients (pts) with locally advanced basal cell carcinoma (laBCC) who progress on or are intolerant to hedgehog inhibitors (HHIs). ANNALS OF ONCOLOGY, 31, S1175–S1176. -
Time to clinically meaningful changes in pain in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab in a phase II clinical trial
Migden, M. R., Rischin, D., Hudgens, S., Chen, C.-I., Schmults, C. D., Pavlick, A. C., … Sasane, M. (2020). Time to clinically meaningful changes in pain in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab in a phase II clinical trial. ANNALS OF ONCOLOGY, 31, S738. -
An exploratory, open-label study of secukinumab in patients with moderate to severe papulopustular rosacea
Kumar, A. M., Chiou, A. S., Shih, Y.-hsien, Li, S., & Chang, A. L. S. (2020). An exploratory, open-label study of secukinumab in patients with moderate to severe papulopustular rosacea. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 83(6), AB88. -
INTERIM ANALYSIS OF PHASE 2 RESULTS FOR CEMIPLIMAB IN PATIENTS WITH METASTATIC BASAL CELL CARCINOMA (MBCC) WHO PROGRESSED ON OR ARE INTOLERANT TO HEDGEHOG INHIBITORS (HHIS)
Lewis, K., Peris, K., Sekulic, A., Stratigos, A., Dunn, L., Eroglu, Z., … Fury, M. (2020). INTERIM ANALYSIS OF PHASE 2 RESULTS FOR CEMIPLIMAB IN PATIENTS WITH METASTATIC BASAL CELL CARCINOMA (MBCC) WHO PROGRESSED ON OR ARE INTOLERANT TO HEDGEHOG INHIBITORS (HHIS). JOURNAL FOR IMMUNOTHERAPY OF CANCER. BMJ PUBLISHING GROUP. -
A phase I study of CX-4945 administered orally twice daily to patients with advanced basal cell carcinoma.
Eroglu, Z., Cowey, C. L., Soong, J., McCormick, D., Fan, P., Chen, J., … Chang, A. L. S. (2020). A phase I study of CX-4945 administered orally twice daily to patients with advanced basal cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY, 38(15). -
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos, A. J., Sekulic, A., Peris, K., Bechter, O., Prey, S., Kaatz, M., … Fury, M. G. (2021). Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial. The Lancet. Oncology. -
Association of ruxolitinib with NMSCs risk in patients with polycythemia vera and myelofibrosis
Lin, J., Li, S., Li, S., Kiamanesh, E., Aasi, S., Kwong, B., & Chang, A. (2021). Association of ruxolitinib with NMSCs risk in patients with polycythemia vera and myelofibrosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(5), S43. -
Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes
Chang, A. L. S. (2020). Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes. BASAL CELL CARCINOMA: ADVANCES IN TREATMENT AND RESEARCH, 19–23. -
Integrated analysis of a phase 2 study of cemiplimab in advanced cutaneous squamous cell carcinoma: extended follow-up of outcomes and quality of life analysis.
Rischin, D., Khushalani, N. I., Schmults, C. D., Guminski, A., Chang, A. L., Lewis, K. D., … Migden, M. R. (2021). Integrated analysis of a phase 2 study of cemiplimab in advanced cutaneous squamous cell carcinoma: extended follow-up of outcomes and quality of life analysis. Journal for Immunotherapy of Cancer, 9(8). -
Antineoplastic therapy after discontinuation of sonidegib 200 mg in patients with advanced basal cell carcinoma: Results from the 42-month, randomized, double-blind BOLT study
Gutzmer, R., Guminski, A., Foley, P., Chang, A. L. S., Lewis, K., Squittieri, N., & Loquai, C. (2021). Antineoplastic therapy after discontinuation of sonidegib 200 mg in patients with advanced basal cell carcinoma: Results from the 42-month, randomized, double-blind BOLT study. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. MOSBY-ELSEVIER. -
First reported case of Wohlfahrtiimonas chitiniclastica infection in California JAAD Case Reports
Leelou, M. C., Perrault, D. P., Siravaj, D., Chang, A. S., Chen, K., Trotsyuk, A., … Gurtner, G. C. (2021). First reported case of Wohlfahrtiimonas chitiniclastica infection in California JAAD Case Reports. Journal of the American Academy of Dermatology Case Reports. -
Health-related Quality of Life (HRQoL) in Patients with advanced cutaneous Squamous Cell Carcinoma (CSCC) treated with Cemiplimab: Post hoc exploratory Analysis of a clinical Phase-2-Study
Migden, M. R., Rischin, D., Sasane, M., Mastey, V., Pavlick, A., Schmults, C. D., … Chen, C. I. (2021). Health-related Quality of Life (HRQoL) in Patients with advanced cutaneous Squamous Cell Carcinoma (CSCC) treated with Cemiplimab: Post hoc exploratory Analysis of a clinical Phase-2-Study. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. WILEY. -
Primary Analysis of Phase-2-Results for Cemiplimab in Patients (pts) with locally advanced Basal Cell Carcinoma (laBCC) who progress or cannot tolerate Hedgehog Inhibitors (HHI)
Stratigos, A. J., Sekulic, A., Peris, K., Bechter, O., Dutriaux, C., Kaatz, M., … Fury, M. G. (2021). Primary Analysis of Phase-2-Results for Cemiplimab in Patients (pts) with locally advanced Basal Cell Carcinoma (laBCC) who progress or cannot tolerate Hedgehog Inhibitors (HHI). JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. WILEY. -
A 10-year retrospective cohort study of ruxolitinib and association with non-melanoma skin cancer in polycythemia vera and myelofibrosis patients.
Lin, J. Q., Li, S. Q., Li, S., Kiamanesh, E. F., Aasi, S. Z., Kwong, B. Y., & Chang, A. L. (2021). A 10-year retrospective cohort study of ruxolitinib and association with non-melanoma skin cancer in polycythemia vera and myelofibrosis patients. Journal of the American Academy of Dermatology. -
Phase 2 study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC): follow-up at 43 months
Rischin, D., Khushalani, N. I., Schmults, C. D., Guminski, A., Chang, A. L. S., Lewis, K. D., … Migden, M. R. (2021). Phase 2 study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC): follow-up at 43 months. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY. -
Real-world assessment and treatment of locally advanced basal cell carcinoma: Findings from the RegiSONIC disease registry.
Sekulic, A., Yoo, S., Kudchadkar, R., Guillen, J., Rogers, G., Chang, A. L., … Lacouture, M. (1800). Real-world assessment and treatment of locally advanced basal cell carcinoma: Findings from the RegiSONIC disease registry. PloS One, 17(1), e0262151. -
Partnering with a senior living community to optimize teledermatology via full body skin screening during the COVID-19 pandemic: a pilot program
Trinh, P., Yekrang, K., Phung, M., Pugliese, S., Chang, A. S., Bailey, E., … Sarin, K. (2022). Partnering with a senior living community to optimize teledermatology via full body skin screening during the COVID-19 pandemic: a pilot program. Skin Health and Disease. -
Immunotherapy for Keratinocyte Cancers. Part 1: Immune-Related Epidemiology, Risk Factors, Pathogenesis, and Immunotherapy Management of Keratinocytic Cancers
Neuner, R., Lee, J., Park, C., Rieger, K. E., Colevas, A. D., & Chang, A. S. (2023). Immunotherapy for Keratinocyte Cancers. Part 1: Immune-Related Epidemiology, Risk Factors, Pathogenesis, and Immunotherapy Management of Keratinocytic Cancers. Journal of the American Academy of Dermatology, 88(6). -
Recurrent bilateral cutaneous squamous cell carcinoma arising within pretibial hypertrophic lichen planus with metastasis while on cemiplimab
Leeolou, M., Burgren, N., Lee, C., Momeni, A., Pinto, H., Johannet, P., … Chang, A. L. S. (2022). Recurrent bilateral cutaneous squamous cell carcinoma arising within pretibial hypertrophic lichen planus with metastasis while on cemiplimab. Journal of the American Academy of Dermatology Case Reports. -
Primary analysis of Phase 2 results for cemiplimab in patients with metastatic basal cell carcinoma who progressed on or were intolerant to hedgehog inhibitors
Lewis, K. D., Perris, K., Sekulic, A., Stratigos, A., Duecker, P., Eroglu, Z., … Fury, M. G. (2022). Primary analysis of Phase 2 results for cemiplimab in patients with metastatic basal cell carcinoma who progressed on or were intolerant to hedgehog inhibitors. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. WILEY. -
Phase 2 study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Long-term follow-up
Stratigos, A., Sekulic, A., Perris, K., Bechter, O., Prey, S., Kaatz, M., … Fury, M. G. (2022). Phase 2 study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Long-term follow-up. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. WILEY. -
Incorporating the "4Ms" framework to improve outpatient geriatric dermatology care.
Perry, W. M., Vora, P., Oh, G., Park, C., & Chang, A. L. (2022). Incorporating the "4Ms" framework to improve outpatient geriatric dermatology care. Journal of the American Geriatrics Society. -
Phase II study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC): Final analysis from EMPOWER-CSCC-1 groups 1, 2 and 3
Migden, M. R., Schmults, C., Khushanlani, N., Guminski, A., Chang, A. L., Lewis, K., … Rischin, D. (2022). Phase II study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC): Final analysis from EMPOWER-CSCC-1 groups 1, 2 and 3. ANNALS OF ONCOLOGY. ELSEVIER. -
Immunotherapy for keratinocyte cancers. Part II: Identification and management of cutaneous side effects of immunotherapy treatments.
Chang, A. L., Zaba, L., & Kwong, B. Y. (2023). Immunotherapy for keratinocyte cancers. Part II: Identification and management of cutaneous side effects of immunotherapy treatments. Journal of the American Academy of Dermatology, 88(6), 1243–1255. -
Advances in cutaneous squamous cell carcinoma.
Winge, M. C., Kellman, L. N., Guo, K., Tang, J. Y., Swetter, S. M., Aasi, S. Z., … Khavari, P. A. (2023). Advances in cutaneous squamous cell carcinoma. Nature Reviews. Cancer. -
Correlation of Ultraviolet Radiation Levels With the Incidence of Cutaneous Squamous Cell and Merkel Cell Carcinomas in Non-sunbelt Locales in the United States: 2010-2017
Vora, P. S., Li, S., Oh, G., Webb, T., Perry, W., Park, C., & Chang, A. L. S. (2023). Correlation of Ultraviolet Radiation Levels With the Incidence of Cutaneous Squamous Cell and Merkel Cell Carcinomas in Non-sunbelt Locales in the United States: 2010-2017. Cureus, 15(6). -
An exploratory, comparative case series of calcitonin gene-related peptide monoclonal antibodies in migraine patients with rosacea.
Sia, T., Webb, T., Li, S., Moskatel, L. S., & Chang, A. L. (2023). An exploratory, comparative case series of calcitonin gene-related peptide monoclonal antibodies in migraine patients with rosacea. The British Journal of Dermatology. -
Use of calcitonin gene-related peptide monoclonal antibodies in patients with rosacea: An exploratory, comparative case series
Sia, T., Webb, T., Li, S., Moskatel, L., & Chang, A. L. (2023). Use of calcitonin gene-related peptide monoclonal antibodies in patients with rosacea: An exploratory, comparative case series. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ELSEVIER SCIENCE INC. -
Primary analysis of phase 2 results with cemiplimab in metastatic basal cell carcinoma that is refractory to hedgehog pathway inhibitors
Lewis, K. D., Peris, K., Sekulic, A., Stratigos, 1. J., Dunn, L., Eroglu, Z., & Chang, A. L. S. (2023). Primary analysis of phase 2 results with cemiplimab in metastatic basal cell carcinoma that is refractory to hedgehog pathway inhibitors. Annals of Oncology, Accepted. -
Phase 2 open-label, multicenter, single-arm study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Extended follow-up.
Stratigos, A. J., Sekulic, A., Peris, K., Bechter, O., Prey, S., Lewis, K. D., … Fury, M. G. (2023). Phase 2 open-label, multicenter, single-arm study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Extended follow-up. Journal of the American Academy of Dermatology.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Human Skin Aging: Clinical Parameters and Gene Expression Profiling »
- Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer »
- A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma »
- An Observational Study of Treatment Patterns and Effectiveness and Safety Outcomes in Advanced Basal Cell Carcinoma and Basal Cell Carcinoma Nevus Syndrome Patients(RegiSONIC) »
- PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy »
- Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome) »
- CemiplimAb Survivorship Epidemiology »
- Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630) »
Practice Locations
Skin Cancer Program in Palo Alto Palo Alto, CA
Palo Alto, CASkin Cancer Program in Palo Alto
900 Blake Wilbur Drive, 3rd Floor
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »High-Risk Skin Cancer Clinic Redwood City, CA
Redwood City, CAHigh-Risk Skin Cancer Clinic
450 Broadway Street, Pavilion B, 4th Floor
Redwood City , CA 94063
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
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