Shoa L. Clarke, MD, PhD

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5.0/5

10 Patient Ratings »

28 Patient Reviews »

Biography

Dr. Clarke is a preventive cardiologist and a physician-scientist focused on disease prevention. He earned his undergraduate degree in human biology from the Division of Nutritional Sciences at Cornell University before obtaining his MD and PhD (genetics) from Stanford University School of Medicine. He has completed clinical training in internal medicine (Brigham & Women’s Hospital), pediatrics (Boston Children’s Hospital), and cardiovascular medicine (Stanford Hospital), and he is board certified in all three specialties. His research is focused on 1) understanding complex disease genetics in diverse populations, 2) integrating monogenic and polygenic risk with clinical risk, 3) large-scale phenotyping using the electronic health record and medical images. His clinical practice focuses on identifying risk factors for cardiovascular disease with the goal of promoting health and longevity through evidence-based personalized treatment. He is interested in developing family-centric approaches for the treatment of adults and children carrying genetic risk for disease.

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Professional Summary

Education & Certifications

Board certified, American Board of Internal Medicine, Cardiovascular Disease
Board certified, American Board of Pediatrics, Pediatrics
Board certified, American Board of Internal Medicine, Internal Medicine

Fellow, Stanford University School of Medicine, Cardiovascular Medicine (2020)

Resident, Brigham & Women's Hospital and Boston Children's Hospital, Internal Medicine and Pediatrics (2017)

PhD, Stanford University School of Medicine, Genetics (2013)

MD, Stanford University School of Medicine (2013)

Honors & Awards

Chair Diversity Investigator Award, Stanford University Department of Medicine (2021)
Chief Fellow, Stanford Division of Cardiovascular Medicine (2019)
Gilliam Fellow, Howard Hughes Medical Institute (2008 - 2013)

House Officer Research Award, Boston Children's Hospital (2016)

Resource Centers for Minority Aging Research (RCMAR) Scientist, National Institute on Aging (2022)

Publications

GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., … Bejerano, G. (2010). GREAT improves functional interpretation of cis-regulatory regions. NATURE BIOTECHNOLOGY, 28(5), 495–U155.
Control of Pelvic Girdle Development by Genes of the Pbx Family and Emx2
Capellini, T. D., Handschuh, K., Quintana, L., Ferretti, E., Di Giacomo, G., Fantini, S., … Selleri, L. (2011). Control of Pelvic Girdle Development by Genes of the Pbx Family and Emx2. DEVELOPMENTAL DYNAMICS, 240(5), 1173–89.
Coding exons function as tissue-specific enhancers of nearby genes
Birnbaum, R. Y., Clowney, E. J., Agamy, O., Kim, M. J., Zhao, J., Yamanaka, T., … Ahituv, N. (2012). Coding exons function as tissue-specific enhancers of nearby genes. GENOME RESEARCH, 22(6), 1059–68.

Human Developmental Enhancers Conserved between Deuterostomes and Protostomes
Clarke, S. L., VanderMeer, J. E., Wenger, A. M., Schaar, B. T., Ahituv, N., & Bejerano, G. (2012). Human Developmental Enhancers Conserved between Deuterostomes and Protostomes. PLOS GENETICS, 8(8).

PRISM offers a comprehensive genomic approach to transcription factor function prediction.
Wenger, A. M., Clarke, S. L., Guturu, H., Chen, J., Schaar, B. T., McLean, C. Y., & Bejerano, G. (2013). PRISM offers a comprehensive genomic approach to transcription factor function prediction. Genome Research, 23(5), 889–904.

The enhancer landscape during early neocortical development reveals patterns of dense regulation and co-option.
Wenger, A. M., Clarke, S. L., Notwell, J. H., Chung, T., Tuteja, G., Guturu, H., … Bejerano, G. (2013). The enhancer landscape during early neocortical development reveals patterns of dense regulation and co-option. PLoS Genetics, 9(8).

Erosion of Conserved Binding Sites in Personal Genomes Points to Medical Histories.
Guturu, H., Chinchali, S., Clarke, S. L., & Bejerano, G. (2016). Erosion of Conserved Binding Sites in Personal Genomes Points to Medical Histories. PLoS Computational Biology, 12(2).

Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead.
Clarke, S. L., & Assimes, T. L. (2018). Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead. Current Atherosclerosis Reports, 20(9), 47.

Performance of Polygenic Risk Scores for Coronary Artery Disease in the Million Veteran Program
Tcheandjieu, C., Zhu, X., Ma, S., Hilliard, A., Clarke, S. L., Lynch, J. A., … Assimes, T. L. (2019). Performance of Polygenic Risk Scores for Coronary Artery Disease in the Million Veteran Program. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.

Cardiorespiratory Fitness, Body-Mass Index, and Markers of Insulin Resistance in Apparently Healthy Women and Men.
Clarke, S. L., Reaven, G. M., Leonard, D., Barlow, C. E., Haskell, W. L., Willis, B. L., … Maron, D. J. (2020). Cardiorespiratory Fitness, Body-Mass Index, and Markers of Insulin Resistance in Apparently Healthy Women and Men. The American Journal of Medicine.

The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case.
Wand, H., Knowles, J. W., & Clarke, S. L. (2021). The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case. Current Opinion in Lipidology.

Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries.
Weale, M. E., Riveros-Mckay, F., Selzam, S., Seth, P., Moore, R., Tarran, W. A., … Donnelly, P. (2021). Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries. The American Journal of Cardiology.

A New Era for Preventive Cardiology.
Clarke, S. L. (2021). A New Era for Preventive Cardiology. Trends in Cardiovascular Medicine.

Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals with Atrial Fibrillation.
O'Sullivan, J. W., Shcherbina, A., Justesen, J. M., Turakhia, M., Perez, M., Wand, H., … Ashley, E. A. (2021). Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals with Atrial Fibrillation. Circulation. Genomic and Precision Medicine.

BROAD CLINICAL MANIFESTATIONS OF POLYGENIC RISK FOR CORONARY ARTERY DISEASE IN THE WOMEN'S HEALTH INITIATIVE
Parham, M., Clarke, S., Tcheandjieu, C., Hilliard, A., & Assimes, T. (2021). BROAD CLINICAL MANIFESTATIONS OF POLYGENIC RISK FOR CORONARY ARTERY DISEASE IN THE WOMEN'S HEALTH INITIATIVE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC.

Associations of Genetically Predicted Lipoprotein (a) Levels with Cardiovascular Traits in Individuals of European and African Ancestry.
Satterfield, B. A., Dikilitas, O., Safarova, M. S., Clarke, S. L., Tcheandjieu, C., Zhu, X., … Kullo, I. J. (2021). Associations of Genetically Predicted Lipoprotein (a) Levels with Cardiovascular Traits in Individuals of European and African Ancestry. Circulation. Genomic and Precision Medicine.

The Propagation of Racial Disparities in Cardiovascular Genomics Research.
Clarke, S. L., Assimes, T. L., & Tcheandjieu, C. (2021). The Propagation of Racial Disparities in Cardiovascular Genomics Research. Circulation. Genomic and Precision Medicine, CIRCGEN121003178.

Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation
Osullivan, J. W., Shcherbina, A., Justesen, J. M., Turakhia, M., Perez, M. V., Wand, H., … Ashley, E. A. (2020). Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.

LPA Variants Are Associated With Aortic Valve Stenosis, Heart Failure and Chronic Kidney Disease
Dikilitas, O., Satterfield, B. A., Safarova, M., Clarke, S. L., Tcheandjieu, C., Zhu, X., … Kullo, I. J. (2020). LPA Variants Are Associated With Aortic Valve Stenosis, Heart Failure and Chronic Kidney Disease. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.

Risk of Coronary Artery Disease Associated With Familial Hypercholesterolemia Genetic Variants is Independent of Historical Low-density Lipoprotein Cholesterol Exposure
Clarke, S. L., Tcheandjieu, C., Hilliard, A., Lee, K. M., Lynch, J., Chang, K.-M., … Assimes, T. L. (2020). Risk of Coronary Artery Disease Associated With Familial Hypercholesterolemia Genetic Variants is Independent of Historical Low-density Lipoprotein Cholesterol Exposure. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.

Time to Relax the 40-Year Age Threshold for Pharmacologic Cholesterol Lowering.
Heidenreich, P. A., Clarke, S. L., & Maron, D. J. (2021). Time to Relax the 40-Year Age Threshold for Pharmacologic Cholesterol Lowering. Journal of the American College of Cardiology, 78(20), 1965–1967.

The power of genetic diversity in genome-wide association studies of lipids.
Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J., Ramdas, S., … Willer, C. J. (2021). The power of genetic diversity in genome-wide association studies of lipids. Nature.

ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis.
Cheng, P., Wirka, R. C., Clarke, L. S., Zhao, Q., Kundu, R., Nguyen, T., … Quertermous, T. (2022). ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis. Circulation.

Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure.
Clarke, S. L., Tcheandjieu, C., Hilliard, A. T., Lee, M., Lynch, J., Chang, K.-M. M., … Assimes, T. L. (2022). Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Circulation. Genomic and Precision Medicine, CIRCGEN121003501.

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., … Natarajan, P. (2022). Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Science Advances, 8(14), eabl6579.

Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management.
Khankari, N. K., Keaton, J. M., Walker, V. M., Lee, K. M., Shuey, M. M., Clarke, S. L., … Edwards, T. L. (2022). Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management. EBioMedicine, 80, 104038.

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.
Patel, R. A., Musharoff, S. A., Spence, J. P., Pimentel, H., Tcheandjieu, C., Mostafavi, H., … Pritchard, J. K. (2022). Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits. American Journal of Human Genetics.

Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations.
Dikilitas, O., Schaid, D. J., Tcheandjieu, C., Clarke, S. L., Assimes, T. L., & Kullo, I. J. (2022). Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations. Current Cardiology Reports.

Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics
Clarke, S. L., Huang, R. D. L., Hilliard, A. T., Tcheandjieu, C., Lynch, J., Damrauer, S. M., … Assimes, T. L. (2022). Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics. CIRCULATION, 146(3), 265–267.

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.
Tcheandjieu, C., Zhu, X., Hilliard, A. T., Clarke, S. L., Napolioni, V., Ma, S., … Assimes, T. L. (2022). Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nature Medicine.

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., … Brown, C. D. (2022). A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. American Journal of Human Genetics, 109(8), 1366–1387.

Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative.
Clarke, S. L., Parham, M., Lankester, J., Shadyab, A. H., Liu, S., Kooperberg, C., … Assimes, T. L. (2022). Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative. Communications Medicine, 2, 108.

The Contribution of Rare Variants to the Heritability of Coronary Artery Disease Based on 38,544 Whole Genome Sequences from the NHLBI TOPMed Program
Rocheleau, G., Clarke, S. L., Hasbani, N. R., Peyser, P. A., Vasan, R. S., Rotter, J. I., … Do, R. (2022). The Contribution of Rare Variants to the Heritability of Coronary Artery Disease Based on 38,544 Whole Genome Sequences from the NHLBI TOPMed Program. GENETIC EPIDEMIOLOGY. WILEY.

Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes.
Lankester, J., Li, J., Salfati, E. L., Stefanick, M. L., Chan, K. H., Liu, S., … Assimes, T. L. (2022). Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes. International Journal of Epidemiology.

Confounders mediate AI prediction of demographics in medical imaging.
Duffy, G., Clarke, S. L., Christensen, M., He, B., Yuan, N., Cheng, S., & Ouyang, D. (2022). Confounders mediate AI prediction of demographics in medical imaging. NPJ Digital Medicine, 5(1), 188.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., … Peloso, G. M. (2022). Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology, 23(1), 268.

The Value of Measuring Lipoprotein(a) in Children.
Khoury, M., & Clarke, S. L. (2023). The Value of Measuring Lipoprotein(a) in Children. Circulation, 147(1), 32–34.

Does low-density lipoprotein fully explain atherosclerotic risk in familial hypercholesterolemia?
Clarke, S. L. (2023). Does low-density lipoprotein fully explain atherosclerotic risk in familial hypercholesterolemia? Current Opinion in Lipidology.

Deep learning-enabled analysis of medical images identifies cardiac sphericity as an early marker of cardiomyopathy and related outcomes.
Vukadinovic, M., Kwan, A. C., Yuan, V., Salerno, M., Lee, D. C., Albert, C. M., … Clarke, S. L. (2023). Deep learning-enabled analysis of medical images identifies cardiac sphericity as an early marker of cardiomyopathy and related outcomes. Med (New York, N.Y.).

A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records.
Shuey, M. M., Lee, K. M., Keaton, J., Khankari, N. K., Breeyear, J. H., Walker, V. M., … Edwards, T. L. (2023). A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records. EBioMedicine, 94, 104674.

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.
Patel, A. P., Wang, M., Ruan, Y., Koyama, S., Clarke, S. L., Yang, X., … Khera, A. V. (2023). A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nature Medicine.

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.
Guarischi-Sousa, R., Salfati, E., Kho, P. F., Iyer, K. R., Hilliard, A. T., Herrington, D. M., … Assimes, T. L. (2023). Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults. Circulation. Genomic and Precision Medicine, e004047.

Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
de Vries, P. S., Conomos, M. P., Singh, K., Nicholson, C. J., Jain, D., Hasbani, N. R., … Malhotra, R. (2023). Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. NATURE CARDIOVASCULAR RESEARCH, 2(12), 1159-+.

Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.
Smith, J. L., Tcheandjieu, C., Dikilitas, O., Iyer, K., Miyazawa, K., Hilliard, A., … Kullo, I. J. (2024). Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization. Circulation. Genomic and Precision Medicine, e004272.

Practice Locations

Preventive Cardiology Stanford, CA

Stanford, CA

Preventive Cardiology

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 725-5909

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Patient Ratings

(10 Ratings)

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Patient Reviews

(28 reviews)

I feel heard & I appreciate the time spent to explain condition, meditations, etc

Feb 2024

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Verified SHC Patient

Dr Lee Clarke is the best! Thank you for your help and knowledge

Feb 2024

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Verified SHC Patient

He is awesome! So knowledgeable and personable. He takes the time to listen to me and explains things that are easy to understand and helpful.

Nov 2023

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Verified SHC Patient

I every confidence in Dr. Clarke as my physician! He's knowledgeable, happy to answer my questions, explain and help me understand my condition, care option's and why. Does not hurry you off, he takes time to understand.

Jul 2023

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Verified SHC Patient

Thank you Dr Lee. I feel safer when a doctor like you talks about patientâ€™s (me) concerns not making me feel the need to hurry and end the conversation, and you explained everything for me to understand things about my concerns.

May 2023

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Verified SHC Patient

Dr. Clarke did an exceptional job in explaining my lab results and answering all my questions. He is very genuine and caring person that helps create an atmosphere of trust and support during the visit.

Apr 2023

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Verified SHC Patient

Dr Clarke talked slowly and clearly which ensured that everything was effectively communicated. As a scientist, it did feel a little slow to me, but I understand that it is more important to be clear.

Mar 2023

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Verified SHC Patient

Lee Clarke is an excellent physician.

Feb 2023

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Verified SHC Patient

Dr Clarke is excellent, takes care to listen and explain. He is very knowledgeable!

Dec 2022

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Verified SHC Patient

Good communicator. Patient. Listens.

Nov 2022

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Verified SHC Patient

He is a fine doctor. I like working with him.ðŸ˜Š

Nov 2022

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Verified SHC Patient

He is very easy to talk to and a very good listener.

Nov 2022

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Verified SHC Patient

He is wonderful and really set me in the right direction. it is hard to find a doctor that really cares, i believe he does!

Oct 2022

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Verified SHC Patient

Dr. Clarke is very thorough and knowledgeable; he explained all the tests and procedures in simple terms.

Sep 2022

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Verified SHC Patient

We discussed the questions that I had and I got the information I was hoping to get. It was great.

Sep 2022

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Verified SHC Patient

I had a very good and informative meeting

May 2022

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Verified SHC Patient

Dr.Clarke is a caring professional.

Apr 2022

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Verified SHC Patient

Thank you I appreciate you taking the time to explain thanks!

Apr 2022

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Verified SHC Patient

Really glad and fortunate to have Dr. Clarke as my doctor. He is friendly, knowledgeable, and great. Thank you.

Jan 2022

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Verified SHC Patient

Dr. Lee is great.He address all my concerns.

Sep 2021

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Verified SHC Patient

Excellent doctor. Knowledgeable, good listener, empathetic, responsive....first-rate, a real keeper.

Aug 2021

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Verified SHC Patient

Dr Lee Clarke is very thorough. He is also kind, calm and pays close attention to what Iâ€™m saying and asking. He listens carefully and allows me to express my thoughts, even if they are jumbled. He is present in our conversation, gracefully addresses my concerns and thoughtfully answers my questions. He is extremely knowledgeable and maps out a plan for me. All of these traits make me feel confident under his care. Thank you Dr Clarke.

Aug 2021

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Verified SHC Patient

Good bedside manners. Respectful. Knowledgeable. Good explanations. Likeable.

Aug 2021

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Verified SHC Patient

Grateful Dr Clarke allowed time for and addressed questions. Appreciated to offer information and studies to be sent to me to read for additional education.

Jul 2021

•

Verified SHC Patient

He is an excellent and caring physician. I am grateful to be under his care.

Jul 2021

•

Verified SHC Patient

Excellent provider

Jun 2021

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Verified SHC Patient

Dr. Clarke explained everything I needed to know and we have a plan

Jun 2021

•

Verified SHC Patient

Dr Clarke is such a wonderful doctor, he is thoughtful & kind & knowledgeable about the medicine he practices .

May 2021

•

Verified SHC Patient

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Shoa L. Clarke, MD, PhD

Cardiologist

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Biography

Professional Summary

Education & Certifications

Honors & Awards

Publications

Practice Locations

Preventive Cardiology Stanford, CA

Preventive Cardiology

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Shoa L. Clarke, MD, PhD

Cardiologist

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Biography

Professional Summary

Education & Certifications

Honors & Awards

Publications

Practice Locations

Preventive Cardiology Stanford, CA

Preventive Cardiology

Important Information about Our Organizations and Physician Affiliation

Patient Ratings

How Our Ratings Work

Patient Reviews

(28 reviews)

Referring Physicians

PHYSICIAN HELPLINE