

Biography
Dr. Goldberg received his B.S. magna cum laude from Yale University, and his M.D. and Ph.D. from Stanford University where he made significant discoveries about the failure of optic nerve regeneration. He did his clinical training in ophthalmology and then in glaucoma at the Bascom Palmer Eye Institute, and was awarded a fellowship from the Heed Foundation. He was named the 2010 Scientist of the Year by the Hope For Vision foundation, and received the Cogan award from the Association for Research in Vision and Ophthalmology in 2012. He was elected in 2010 to the American Society of Clinical Investigation, an honorary society of physician scientists. He directs an NIH-funded research laboratory and has developed significant expertise with implementing FDA IND clinical trials for optic nerve neuroprotection and regeneration. His goal is to translate scientific discoveries to patient therapies. A partial list of clinical trials can be found on the department webpage, https://med.stanford.edu/ophthalmology/research/clinical_trials.html.
Professional Summary
Education & Certifications
- Fellowship: Bascom Palmer Eye Institute (2010) FL
- Residency: Bascom Palmer Eye Institute (2008) FL
- Board Certification: American Board of Ophthalmology, Ophthalmology (2009)
- Internship: Santa Clara Valley Medical Center (2004) CA
- Medical Education: Stanford School of Medicine (2003) CA
- Fellowship, Bascom Palmer Eye Institute, Glaucoma (2010)
- PhD, Stanford University, Neurosciences (2003)
- MD, Stanford University, Medicine (2003)
Administrative Appointments
- Chair of Ophthlmology, Stanford University (2015 - Present)
Publications
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The relationship between neuronal survival and regeneration
Goldberg, J. L., & Barres, B. A. (2000). The relationship between neuronal survival and regeneration. ANNUAL REVIEW OF NEUROSCIENCE, 23, 579–612. -
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
Shamah, S. M., Lin, M. Z., Goldberg, J. L., Estrach, S., Sahin, M., Hu, L., … Greenberg, M. E. (2001). EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. CELL, 105(2), 233–44. -
Retinal ganglion cells do not extend axons by default: Promotion by neurotrophic signaling and electrical activity
Goldberg, J. L., Espinosa, J. S., Xu, Y. F., Davidson, N., Kovacs, G. T. A., & Barres, B. A. (2002). Retinal ganglion cells do not extend axons by default: Promotion by neurotrophic signaling and electrical activity. NEURON, 33(5), 689–702. -
Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002). Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. SCIENCE, 296(5574), 1860–64. -
An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells
Goldberg, J. L., Vargas, M. E., Wang, J. T., Mandemakers, W., Oster, S. F., Sretavan, D. W., & Barres, B. A. (2004). An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells. JOURNAL OF NEUROSCIENCE, 24(21), 4989–99. -
Disease gene candidates revealed by expression profiling of retinal ganglion cell development
Wang, J. T., Kunzevitzky, N. J., Dugas, J. C., Cameron, M., Barres, B. A., & Goldberg, J. L. (2007). Disease gene candidates revealed by expression profiling of retinal ganglion cell development. JOURNAL OF NEUROSCIENCE, 27(32), 8593–8603. -
Neural regeneration: Extending axons from bench to brain
Goldberg, J. L., & Barres, B. A. (1998). Neural regeneration: Extending axons from bench to brain. CURRENT BIOLOGY, 8(9), R310–R312. -
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse
Sahin, M., Greer, P. L., Lin, M. Z., Poucher, H., Eberhart, J., Schmidt, S., … Greenberg, M. E. (2005). Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. NEURON, 46(2), 191–204. -
Gene expression profiling of purified retinal ganglion cells
Zack, D. J., Qian, J., Goldberg, J. L., & Farkas, R. H. (2003). Gene expression profiling of purified retinal ganglion cells. Presented at the Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE,FL,FL: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Gene expression profiling of purified rat retinal ganglion cells
Farkas, R. H., Qian, J., Goldberg, J. L., Quigley, H. A., & Zack, D. J. (2004). Gene expression profiling of purified rat retinal ganglion cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45(8), 2503–13. -
Regulation of Intrinsic Axon Growth Ability at Retinal Ganglion Cell Growth Cones
Steketee, M. B., Oboudiyat, C., Daneman, R., Trakhtenberg, E., Lamoureux, P., Weinstein, J. E., … Goldberg, J. L. (2014). Regulation of Intrinsic Axon Growth Ability at Retinal Ganglion Cell Growth Cones. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(7), 4369–77. -
How does an axon grow?
Goldberg, J. L. (2003). How does an axon grow? GENES & DEVELOPMENT, 17(8), 941–58. -
Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation
McCabe, K. L., Kunzevitzky, N. J., Chiswell, B. P., Xia, X., Goldberg, J. L., & Lanza, R. (2015). Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation. PLOS ONE, 10(12). -
Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation
Rocca, C. J., Kreymerman, A., Ur, S. N., Frizzi, K. E., Naphade, S., Lau, A., … Cherqui, S. (2015). Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(12), 7214–23. -
Transplanted neurons integrate into adult retinas and respond to light.
Venugopalan, P., Wang, Y., Nguyen, T., Huang, A., Muller, K. J., & Goldberg, J. L. (2016). Transplanted neurons integrate into adult retinas and respond to light. Nature Communications, 7, 10472-? -
Muscle A-Kinase Anchoring Protein-a is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival.
Wang, Y., Cameron, E. G., Li, J., Stiles, T. L., Kritzer, M. D., Lodhavia, R., … Goldberg, J. L. (2015). Muscle A-Kinase Anchoring Protein-a is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival. EBioMedicine, 2(12), 1880–87. -
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS
Takihara, Y., Inatani, M., Eto, K., Inoue, T., Kreymerman, A., Miyake, S., … Tanihara, H. (2015). In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(33), 10515–20. -
Promoting filopodial elongation in neurons by membrane-bound magnetic nanoparticles
Pita-Thomas, W., Steketee, M. B., Moysidis, S. N., Thakor, K., Hampton, B., & Goldberg, J. L. (2015). Promoting filopodial elongation in neurons by membrane-bound magnetic nanoparticles. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 11(3), 559–67. -
KLF Family Members Regulate Intrinsic Axon Regeneration Ability
Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L. (2009). KLF Family Members Regulate Intrinsic Axon Regeneration Ability. SCIENCE, 326(5950), 298–301. -
Control of Retinal Ganglion Cell Positioning and Neurite Growth: Combining 3D Printing with Radial Electrospun Scaffolds
Kador, K. E., Grogan, S. P., Dorthe, E. W., Venugopalan, P., Malek, M. F., Goldberg, J. L., & D'Lima, D. D. (2016). Control of Retinal Ganglion Cell Positioning and Neurite Growth: Combining 3D Printing with Radial Electrospun Scaffolds. TISSUE ENGINEERING PART A, 22(3-4), 286–94. -
NEUROREGENERATION. Promoting CNS repair.
Cameron, E. G., & Goldberg, J. L. (2016). NEUROREGENERATION. Promoting CNS repair. Science , 353(6294), 30–31. -
Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve.
Goldberg, J. L., Guido, W., & For The Agi Workshop Participants. (2016). Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve. Investigative Ophthalmology & Visual Science, 57(3), 1271–75. -
Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.
Wang, J., Galvao, J., Beach, K. M., Luo, W., Urrutia, R. A., Goldberg, J. L., & Otteson, D. C. (2016). Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. Journal of Biological Chemistry, 291(35), 18084–95. -
Novel Identity and Functional Markers for Human Corneal Endothelial Cells
Bartakova, A., Alvarez-Delfin, K., Weisman, A. D., Salero, E., Raffa, G. A., Merkhofer, R. M., … Goldberg, J. L. (2016). Novel Identity and Functional Markers for Human Corneal Endothelial Cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(6), 2749–62. -
Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium
Ouyang, H., Goldberg, J. L., Chen, S., Li, W., Xu, G.-T., Li, W., … Zack, D. J. (2016). Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(3). -
Cell types differ in global coordination of splicing and proportion of highly expressed genes
Trakhtenberg, E. F., Nam Pho, N., Holton, K. M., Chittenden, T. W., Goldberg, J. L., & Dong, L. (2016). Cell types differ in global coordination of splicing and proportion of highly expressed genes. SCIENTIFIC REPORTS, 6. -
Epigenetic regulation of axon and dendrite growth
Trakhtenberg, E. F., & Goldberg, J. L. (2012). Epigenetic regulation of axon and dendrite growth. FRONTIERS IN MOLECULAR NEUROSCIENCE, 5. -
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Wang, Y., Brown, D. P., Watson, B. D., & Goldberg, J. L. (2015). Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (105). -
Evaluation of Magnetic Micro- and Nanoparticle Toxicity to Ocular Tissues
Raju, H. B., Hu, Y., Vedula, A., Dubovy, S. R., & Goldberg, J. L. (2011). Evaluation of Magnetic Micro- and Nanoparticle Toxicity to Ocular Tissues. PLOS ONE, 6(5). -
Tissue engineering the retinal ganglion cell nerve fiber layer
Kador, K. E., Montero, R. B., Venugopalan, P., Hertz, J., Zindell, A. N., Valenzuela, D. A., … Goldberg, J. L. (2013). Tissue engineering the retinal ganglion cell nerve fiber layer. BIOMATERIALS, 34(17), 4242–50. -
Foxn4 is required for retinal ganglion cell distal axon patterning
Kunzevitzky, N. J., Almeida, M. V., Duan, Y., Li, S., Xiang, M., & Goldberg, J. L. (2011). Foxn4 is required for retinal ganglion cell distal axon patterning. MOLECULAR AND CELLULAR NEUROSCIENCE, 46(4), 731–41. -
Signaling Endosomes and Growth Cone Motility in Axon Regeneration
Steketee, M. B., & Goldberg, J. L. (2012). Signaling Endosomes and Growth Cone Motility in Axon Regeneration. AXON GROWTH AND REGENERATION, PT 2, 106, 35–73. -
Femtosecond Laser-Assisted Astigmatic Keratotomy for Postoperative Trabeculectomy-Induced Corneal Astigmatism
Kankariya, V. P., Diakonis, V. F., Goldberg, J. L., Kymionis, G. D., & Yoo, S. H. (2014). Femtosecond Laser-Assisted Astigmatic Keratotomy for Postoperative Trabeculectomy-Induced Corneal Astigmatism. JOURNAL OF REFRACTIVE SURGERY, 30(7), 502–504. -
Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center.
Griffith, J. F., & Goldberg, J. L. (2015). Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center. Clinical Ophthalmology (Auckland, N.Z.), 9, 1275–84. -
Atypical mild enhanced S-Cone syndrome with novel compound heterozygosity of the NR2E3 gene
Lam, B. L., Goldberg, J. L., Hartley, K. L., & Stone, E. M. (2007). Atypical mild enhanced S-Cone syndrome with novel compound heterozygosity of the NR2E3 gene. AMERICAN JOURNAL OF OPHTHALMOLOGY, 144(1), 157–59. -
Four Steps to Optic Nerve Regeneration
Moore, D. L., & Goldberg, J. L. (2010). Four Steps to Optic Nerve Regeneration. JOURNAL OF NEURO-OPHTHALMOLOGY, 30(4), 347–360. -
A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates
Johnstone, A. L., Reierson, G. W., Smith, R. P., Goldberg, J. L., Lemmon, V. P., & Bixby, J. L. (2012). A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates. MOLECULAR AND CELLULAR NEUROSCIENCE, 50(2), 125–35. -
ACUTE RETINAL PIGMENT EPITHELIUM DETACHMENTS AFTER PHOTOCOAGULATION
Moysidis, S. N., Vajzovic, L., Gregori, G., & Goldberg, J. L. (2014). ACUTE RETINAL PIGMENT EPITHELIUM DETACHMENTS AFTER PHOTOCOAGULATION. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 34(4), 749–60. -
High content screening of cortical neurons identifies novel regulators of axon growth
Blackmore, M. G., Moore, D. L., Smith, R. P., Goldberg, J. L., Bixby, J. L., & Lemmon, V. P. (2010). High content screening of cortical neurons identifies novel regulators of axon growth. MOLECULAR AND CELLULAR NEUROSCIENCE, 44(1), 43–54. -
Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement
Chang, E. E., & Goldberg, J. L. (2012). Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement. OPHTHALMOLOGY, 119(5), 979–86. -
Amacrine Cell Subtypes Differ in Their Intrinsic Neurite Growth Capacity
Kunzevitzky, N. J., Willeford, K. T., Feuer, W. J., Almeida, M. V., & Goldberg, J. L. (2013). Amacrine Cell Subtypes Differ in Their Intrinsic Neurite Growth Capacity. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(12), 7603–13. -
The role of soluble adenylyl cyclase in neurite outgrowth
Stiles, T. L., Kapiloff, M. S., & Goldberg, J. L. (2014). The role of soluble adenylyl cyclase in neurite outgrowth. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1842(12), 2561–68. -
Amacrine Cell Gene Expression and Survival Signaling: Differences from Neighboring Retinal Ganglion Cells
Kunzevitzky, N. J., Almeida, M. V., & Goldberg, J. L. (2010). Amacrine Cell Gene Expression and Survival Signaling: Differences from Neighboring Retinal Ganglion Cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(7), 3800–3812. -
Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract
Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., … Bixby, J. L. (2012). Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(19), 7517–7522. -
The Role of Serotonin in Axon and Dendrite Growth
Trakhtenberg, E. F., & Goldberg, J. L. (2012). The Role of Serotonin in Axon and Dendrite Growth. AXON GROWTH AND REGENERATION, PT 2, 106, 105–26. -
Survival and Integration of Developing and Progenitor-Derived Retinal Ganglion Cells Following Transplantation
Hertz, J., Qu, B., Hu, Y., Patel, R. D., Valenzuela, D. A., & Goldberg, J. L. (2014). Survival and Integration of Developing and Progenitor-Derived Retinal Ganglion Cells Following Transplantation. CELL TRANSPLANTATION, 23(7), 855–72. -
The N-terminal Set-beta Protein Isoform Induces Neuronal Death
Trakhtenberg, E. F., Morkin, M. I., Patel, K. H., Fernandez, S. G., Sang, A., Shaw, P., … Goldberg, J. L. (2015). The N-terminal Set-beta Protein Isoform Induces Neuronal Death. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(21), 13417–26. -
Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth
Steketee, M. B., Moysidis, S. N., Jin, X.-L., Weinstein, J. E., Pita-Thomas, W., Raju, H. B., … Goldberg, J. L. (2011). Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(47), 19042–47. -
Nanotechnology and glaucoma: little particles for a big disease
Pita-Thomas, D. W., & Goldberg, J. L. (2013). Nanotechnology and glaucoma: little particles for a big disease. CURRENT OPINION IN OPHTHALMOLOGY, 24(2), 130–35. -
Electrical activity enhances neuronal survival and regeneration
Corredor, R. G., & Goldberg, J. L. (2009). Electrical activity enhances neuronal survival and regeneration. JOURNAL OF NEURAL ENGINEERING, 6(5). -
Investigation of nanoparticles using magnetic resonance imaging after intravitreal injection
Raju, H. B., Hu, Y., Padgett, K. R., Rodriguez, J. E., & Goldberg, J. L. (2012). Investigation of nanoparticles using magnetic resonance imaging after intravitreal injection. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 40(1), 100–107. -
A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells
Hertz, J., Robinson, R., Valenzuela, D. A., Layik, E. B., & Goldberg, J. L. (2013). A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells. ACTA BIOMATERIALIA, 9(8), 7622–29. -
Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
Apara, A., & Goldberg, J. L. (2014). Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors. NEURAL REGENERATION RESEARCH, 9(15), 1418–21. -
Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography
Leahy, C., Radhakrishnan, H., Weiner, G., Goldberg, J. L., & Srinivasan, V. J. (2015). Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(10), 5785–93. -
Neurotrophic Effect of a Novel TrkB Agonist on Retinal Ganglion Cells
Hu, Y., Cho, S., & Goldberg, J. L. (2010). Neurotrophic Effect of a Novel TrkB Agonist on Retinal Ganglion Cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(3), 1747–54. -
Epigenetic regulation of axon and dendrite growth.
Trakhtenberg, E. F., & Goldberg, J. L. (2012). Epigenetic regulation of axon and dendrite growth. Frontiers in Molecular Neuroscience, 5, 24-? -
Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold
Kador, K. E., Alsehli, H. S., Zindell, A. N., Lau, L. W., Andreopoulos, F. M., Watson, B. D., & Goldberg, J. L. (2014). Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold. ACTA BIOMATERIALIA, 10(12), 4939–46. -
Clinical and Electrophysiologic Characteristics of a Large Kindred with X-Linked Retinitis Pigmentosa Associated with the RPGR Locus
Tzu, J. H., Arguello, T., Berrocal, A. M., Berrocal, M., Weisman, A. D., Liu, M., … Lam, B. L. (2015). Clinical and Electrophysiologic Characteristics of a Large Kindred with X-Linked Retinitis Pigmentosa Associated with the RPGR Locus. OPHTHALMIC GENETICS, 36(4), 321–26. -
Intrinsic neuronal regulation of axon and dendrite growth
Goldberg, J. L. (2004). Intrinsic neuronal regulation of axon and dendrite growth. CURRENT OPINION IN NEUROBIOLOGY, 14(5), 551–57. -
Role of electrical activity in promoting neural repair
Goldberg, J. L. (2012). Role of electrical activity in promoting neural repair. NEUROSCIENCE LETTERS, 519(2), 134–37. -
A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration
Usher, L. C., Johnstone, A., Erturk, A., Hu, Y., Strikis, D., Wanner, I. B., … Bixby, J. L. (2010). A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration. JOURNAL OF NEUROSCIENCE, 30(13), 4693–4706. -
Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients.
Goldberg, R. A., Raza, S., Walford, E., Feuer, W. J., & Goldberg, J. L. (2014). Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients. Clinical Ophthalmology (Auckland, N.Z.), 8, 1761–66. -
Retinal repair with induced pluripotent stem cells
Al-Shamekh, S., & Goldberg, J. L. (2014). Retinal repair with induced pluripotent stem cells. TRANSLATIONAL RESEARCH, 163(4), 377–86. -
Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro
Steketee, M. B., Moysidis, S. N., Weinstein, J. E., Kreymerman, A., Silva, J. P., Iqbal, S., & Goldberg, J. L. (2012). Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(11), 7402–11. -
Magnetic field-guided cell delivery with nanoparticle-loaded human corneal endothelial cells
Moysidis, S. N., Alvarez-Delfin, K., Peschansky, V. J., Salero, E., Weisman, A. D., Bartakova, A., … Goldberg, J. L. (2015). Magnetic field-guided cell delivery with nanoparticle-loaded human corneal endothelial cells. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 11(3), 499–509. -
Scaffolds and stem cells: delivery of cell transplants for retinal degenerations.
Kador, K. E., & Goldberg, J. L. (2012). Scaffolds and stem cells: delivery of cell transplants for retinal degenerations. Expert Review of Ophthalmology, 7(5), 459–70. -
Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth
Corredor, R. G., Trakhtenberg, E. F., Pita-Thomas, W., Jin, X., Hu, Y., & Goldberg, J. L. (2012). Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth. JOURNAL OF NEUROSCIENCE, 32(22), 7734–44. -
Regenerative Cell Therapy for Corneal Endothelium.
Bartakova, A., Kunzevitzky, N. J., & Goldberg, J. L. (2014). Regenerative Cell Therapy for Corneal Endothelium. Current Ophthalmology Reports, 2(3), 81–90. -
Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation.
Fang, J., Shaw, P. X., Wang, Y., & Goldberg, J. L. (2016). Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation. ENeuro, 3(1). -
gamma-Synuclein as a marker of retinal ganglion cells
Surgucheva, I., Weisman, A. D., Goldberg, J. L., Shnyra, A., & Surguchov, A. (2008). gamma-Synuclein as a marker of retinal ganglion cells. MOLECULAR VISION, 14(182-84), 1540–1548. -
Multiple Transcription Factor Families Regulate Axon Growth and Regeneration
Moore, D. L., & Goldberg, J. L. (2011). Multiple Transcription Factor Families Regulate Axon Growth and Regeneration. DEVELOPMENTAL NEUROBIOLOGY, 71(12), 1186–1211. -
Isolation and Characterization of Mesenchymal Progenitor Cells From Human Orbital Adipose Tissue
Chen, S.-Y., Mahabole, M., Horesh, E., Wester, S., Goldberg, J. L., & Tseng, S. C. G. (2014). Isolation and Characterization of Mesenchymal Progenitor Cells From Human Orbital Adipose Tissue. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(8), 4842–52. -
beta 1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival
Santos, A. R. C., Corredor, R. G., Obeso, B. A., Trakhtenberg, E. F., Wang, Y., Ponmattam, J., … Bajenaru, M. L. (2012). beta 1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival. PLOS ONE, 7(10). -
Regulating Set-beta's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration
Trakhtenberg, E. F., Wang, Y., Morkin, M. I., Fernandez, S. G., Mlacker, G. M., Shechter, J. M., … Goldberg, J. L. (2014). Regulating Set-beta's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration. JOURNAL OF NEUROSCIENCE, 34(21), 7361–74. -
The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center
Griffith, J. F., & Goldberg, J. L. (2016). The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. JOURNAL OF GLAUCOMA, 25(3), E241–E247. -
Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury.
Shaw, P. X., Sang, A., Wang, Y., Ho, D., Douglas, C., Dia, L., & Goldberg, J. L. (2016). Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Experimental Eye Research. -
A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach
Ries, A., Goldberg, J. L., & Grimpe, B. (2007). A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach. JOURNAL OF NEUROCHEMISTRY, 103(4), 1491–1505. -
Kruppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration
Moore, D. L., Apara, A., & Goldberg, J. L. (2011). Kruppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration. MOLECULAR AND CELLULAR NEUROSCIENCE, 47(4), 233–43. -
A Novel Rodent Model of Posterior Ischemic Optic Neuropathy
Wang, Y., Brown, D. P., Duan, Y., Kong, W., Watson, B. D., & Goldberg, J. L. (2013). A Novel Rodent Model of Posterior Ischemic Optic Neuropathy. JAMA OPHTHALMOLOGY, 131(2), 194–204. -
Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation.
Shaw, P. X., Fang, J., Sang, A., Wang, Y., Kapiloff, M. S., & Goldberg, J. L. (2016). Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Investigative Ophthalmology & Visual Science, 57(11), 5083–92. -
Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD
Kuriyan, A. E., Albini, T. A., Townsend, J. H., Rodriguez, M., Pandya, H. K., Leonard, R. E., … Goldberg, J. L. (2017). Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD. NEW ENGLAND JOURNAL OF MEDICINE, 376(11), 1047–53. -
Cell types differ in global coordination of splicing and proportion of highly expressed genes.
Trakhtenberg, E. F., Pho, N., Holton, K. M., Chittenden, T. W., Goldberg, J. L., & Dong, L. (2016). Cell types differ in global coordination of splicing and proportion of highly expressed genes. Scientific Reports, 6, 32249-? -
Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, southern coastal Maine
Holman, M. S., Caporale, D. A., Goldberg, J., Lacombe, E., Lubelczyk, C., Rand, P. W., & Smith, R. P. (2004). Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, southern coastal Maine. EMERGING INFECTIOUS DISEASES, 10(4), 744–46. -
Is uveitis associated with topiramate use? A cumulative review.
Goldberg, J. L., Lau, A. G., Fan, B., Ford, L., & Greenberg, H. E. (2016). Is uveitis associated with topiramate use? A cumulative review. Clinical Ophthalmology (Auckland, N.Z.), 10, 1467–70. -
A Cell Culture Approach to Optimized Human Corneal Endothelial Cell Function.
Bartakova, A., Kuzmenko, O., Alvarez-Delfin, K., Kunzevitzky, N. J., & Goldberg, J. L. (2018). A Cell Culture Approach to Optimized Human Corneal Endothelial Cell Function. Investigative Ophthalmology & Visual Science, 59(3), 1617–29. -
Clinical Grade Magnetic Human Corneal Endothelial Cells for Cell Therapy
Kuzmenko, O., Bartakova, A., Kunzevitzky, N. J., & Goldberg, J. L. (2018). Clinical Grade Magnetic Human Corneal Endothelial Cells for Cell Therapy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Generation and purification of functional corneal endothelium-like cells differentiated from human embryonic stem cells
Xia, X., Chang, K.-C., Kuzmenko, O., Kunzevitzky, N. J., Sun, C., Zhang, X., … Goldberg, J. L. (2018). Generation and purification of functional corneal endothelium-like cells differentiated from human embryonic stem cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Development of a Porcine Optic Nerve Injury Model
Holt, D., Por, E., Cleland, J., Harris, J., Gorantla, V., Sandoval, M., … Bramblett, G. T. (2018). Development of a Porcine Optic Nerve Injury Model. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Dynamics of human ON and OFF Visual Pathways
Goldberg, J. L., Yakovleva, A., Hung, B., & Norcia, A. (2018). Dynamics of human ON and OFF Visual Pathways. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
How to measure vision in glaucoma.
Goldberg, J. L. (2013). How to measure vision in glaucoma. JAMA Ophthalmology, 131(12), 1563–4. -
Immunology. Neuroimmune communication.
Trakhtenberg, E. F., & Goldberg, J. L. (2011). Immunology. Neuroimmune communication. Science (New York, N.Y.), 334(6052), 47–8. -
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse.
Zhang, J., Li, L., Huang, H., Fang, F., Webber, H. C., Zhuang, P., … Hu, Y. (2019). Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. ELife, 8. -
Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment.
Boczek, T., Cameron, E. G., Yu, W., Xia, X., Shah, S. H., Castillo Chabeco, B., … Kapiloff, M. S. (2019). Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. -
Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.
Chang, K.-C. C., Sun, C., Cameron, E. G., Madaan, A., Wu, S., Xia, X., … Goldberg, J. L. (2019). Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification. Current Biology : CB. -
Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy.
Xia, X., Atkins, M., Dalal, R., Kuzmenko, O., Chang, K.-C. C., Sun, C. B., … Goldberg, J. L. (2019). Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy. Investigative Ophthalmology & Visual Science, 60(7), 2438–48. -
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse
Zhang, J., Li, L., Huang, H., Fang, F., Webber, H. C., Zhuang, P., … Hu, Y. (2019). Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. ELIFE, 8. -
MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses.
Kreymerman, A., Buickians, D. N., Nahmou, M. M., Tran, T., Galvao, J., Wang, Y., … Goldberg, J. L. (2019). MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses. Scientific Reports, 9(1), 10669. -
Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment
Boczek, T., Cameron, E. G., Yu, W., Xia, X., Shah, S. H., Chabeco, B. C., … Kapiloff, M. S. (2019). Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. JOURNAL OF NEUROSCIENCE, 39(28), 5466–80. -
The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System InVivo.
Schiapparelli, L. M., Shah, S. H., Ma, Y., McClatchy, D. B., Sharma, P., Li, J., … Cline, H. T. (2019). The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System InVivo. Cell Reports, 28(7), 1935. -
SALT Trial: Steroids after Laser Trabeculoplasty: Impact of Short-Term Anti-inflammatory Treatment on Selective Laser Trabeculoplasty Efficacy.
Groth, S. L., Albeiruti, E., Nunez, M., Fajardo, R., Sharpsten, L., Loewen, N., … Goldberg, J. L. (2019). SALT Trial: Steroids after Laser Trabeculoplasty: Impact of Short-Term Anti-inflammatory Treatment on Selective Laser Trabeculoplasty Efficacy. Ophthalmology. -
The Role of MEF2 transcription factors in retinal ganglion cell survival and axon regeneration
Xia, X., Bian, M., Shah, S., Chang, K.-C., Sun, C., Yu, C., … Goldberg, J. L. (2019). The Role of MEF2 transcription factors in retinal ganglion cell survival and axon regeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Dynamic Transcriptional Profiling of Reactive Muller Glia Following Retinal Injury
Ashouri, M., Madaan, A., Nahmou, M., Wang, S., Goldberg, J. L., & Cameron, E. G. (2019). Dynamic Transcriptional Profiling of Reactive Muller Glia Following Retinal Injury. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Cell transplantation of retinal ganglion cells derived from hESCs.
Zhang, X., Tenerelli, K., Wu, S., Xia, X., Yokota, S., Sun, C., … Chang, K.-C. C. (2019). Cell transplantation of retinal ganglion cells derived from hESCs. Restorative Neurology and Neuroscience. -
Reply.
Groth, S. L., & Goldberg, J. L. (2020). Reply. Ophthalmology, 127(2), e17. -
Re: Groth et al.: SALT Trial: steroids after laser trabeculoplasty: impact of short-term anti-inflammatory treatment on selective laser trabeculoplasty efficacy (Ophthalmology. 2019;126:1511-1516) REPLY
Groth, S. L., & Goldberg, J. L. (2020). Re: Groth et al.: SALT Trial: steroids after laser trabeculoplasty: impact of short-term anti-inflammatory treatment on selective laser trabeculoplasty efficacy (Ophthalmology. 2019;126:1511-1516) REPLY. OPHTHALMOLOGY, 127(2), E17. -
Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration.
Chauhan, M. Z., Arcuri, J., Park, K. K., Zafar, M. K., Fatmi, R., Hackam, A. S., … Bhattacharya, S. K. (2020). Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration. IScience, 23(2), 100836. -
Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration.
Cameron, E. G., Xia, X., Galvao, J., Ashouri, M., Kapiloff, M. S., & Goldberg, J. L. (2020). Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration. Bio-Protocol, 10(6). -
The rapid N-wave as a potentially useful measure of the photopic negative response.
Pham, B. H., Goldberg, J. L., & Marmor, M. F. (2020). The rapid N-wave as a potentially useful measure of the photopic negative response. Documenta Ophthalmologica. Advances in Ophthalmology. -
Discovery and clinical translation of novel glaucoma biomarkers.
Beykin, G., Norcia, A. M., Srinivasan, V. J., Dubra, A., & Goldberg, J. L. (2020). Discovery and clinical translation of novel glaucoma biomarkers. Progress in Retinal and Eye Research, 100875. -
NONINFECTIOUS POSTERIOR UVEITIS BRINGING EMERGING TREATMENTS TO THE FOREFRONT
Quan Dong Nguyen, Albini, T., Callanan, D., Goldberg, J. L., Merrill, P. T., & Landa, G. (2020). NONINFECTIOUS POSTERIOR UVEITIS BRINGING EMERGING TREATMENTS TO THE FOREFRONT. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 40. -
An Open-Label Phase Ib Study to Evaluate Retinal Imaging After Short-term Use of the Balance Goggles System (BGS) in Patients with Glaucoma
Li, Z., Knasel, C., Nunez, M., Beykin, G., Goldstein, A., Fisher, A. C., … Goldberg, J. L. (2020). An Open-Label Phase Ib Study to Evaluate Retinal Imaging After Short-term Use of the Balance Goggles System (BGS) in Patients with Glaucoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Retinal organoid differentiation and transplantatio
Chang, K.-C., Luo, Z., Xia, X., Knasel, C., & Goldberg, J. L. (2020). Retinal organoid differentiation and transplantatio. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Transcription factor REST/NRSF regulates optic nerve regeneration and RGC survival
Benowitz, L., Gilbert, H.-ya, Geschwind, D., Kawaguchi, R., Geschwind, D., Goldberg, J. L., & Yin, Y. (2020). Transcription factor REST/NRSF regulates optic nerve regeneration and RGC survival. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Physiological and morphological development of human embryonic stem cell derived retinal ganglion cells
Risner, M. L., Formichella, C., Chamling, X., Reh, T. A., Goldberg, J. L., Zack, D. J., & Calkins, D. J. (2020). Physiological and morphological development of human embryonic stem cell derived retinal ganglion cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Dynamics of Contrast Decrement and Increment Responses in Human Visual Cortex.
Norcia, A. M., Yakovleva, A., Hung, B., & Goldberg, J. L. (2020). Dynamics of Contrast Decrement and Increment Responses in Human Visual Cortex. Translational Vision Science & Technology, 9(10), 6. -
Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy.
Kumar, V., Ali Shariati, M., Mesentier-Louro, L., Jinsook Oh, A., Russano, K., Goldberg, J. L., & Liao, Y. J. (2020). Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy. Current Eye Research, 1–9. -
Molecular Biomarkers for Glaucoma.
Beykin, G., & Goldberg, J. L. (2019). Molecular Biomarkers for Glaucoma. Current Ophthalmology Reports, 7(3), 171–76. -
MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.
Xia, X., Yu, C. Y., Bian, M., Sun, C. B., Tanasa, B., Chang, K.-C. C., … Goldberg, J. L. (2020). MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury. PloS One, 15(12), e0242884. -
Post-translational modification of Sox11 regulates RGC survival and axon regeneration.
Chang, K.-C., Bian, M., Xia, X., Madaan, A., Sun, C., Wang, Q., … Goldberg, J. L. (2021). Post-translational modification of Sox11 regulates RGC survival and axon regeneration. ENeuro.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
Glaucoma Clinic in Palo Alto Palo Alto, CA
Palo Alto, CAGlaucoma Clinic in Palo Alto
2452 Watson Court
Palo Alto , CA 94303
Make An Appointment More Clinic Information » Getting Here »Cataracts and Intraocular Lenses Palo Alto, CA
Palo Alto, CACataracts and Intraocular Lenses
2452 Watson Court
Palo Alto , CA 94303
Make An Appointment More Clinic Information » Getting Here »Glaucoma Clinic Palo Alto, CA
Palo Alto, CAGlaucoma Clinic
2452 Watson Court
Palo Alto , CA 94303
Make An Appointment More Clinic Information » Getting Here »Byers Eye Institute Palo Alto, CA
Palo Alto, CAByers Eye Institute
2452 Watson Court
Palo Alto , CA 94303
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
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