Biography
Dr. Witteles serves as Program Director for the Stanford Internal Medicine residency program -- directly supervising the training of more than 140 physicians each year. He was recognized by Stanford in 2020 with the award for 'Program Director of the Year'. He holds board certification in Internal Medicine, Cardiovascular Disease, and Advanced Heart Failure/Transplant Cardiology.
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Advanced Heart Failure and Transplant Cardiology (2012)
- Fellowship: Stanford University School of Medicine (2007) CA
- Residency: Stanford University School of Medicine (2004) CA
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- Residency: Stanford University School of Medicine (2003) CA
- Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2007)
- Board Certification: American Board of Internal Medicine, Internal Medicine (2003)
- Chief Resident, Stanford University, Internal Medicine (2004)
- Internship: Stanford University School of Medicine (2001) CA
- M.D. with Honors, University of Chicago, Medicine (2000)
- B.A., Northwestern University, Biology/Neuroscience (1996)
- F.A.C.P., American College of Physicians, Internal Medicine (2010)
- F.A.C.C., American College of Cardiology, Cardiology (2008)
- Chief Fellow, Stanford University, Cardiovascular Medicine (2007)
- Medical Education: University of Chicago Pritzker (2000) IL
Honors & Awards
- Calvin Fentress Research Fellowship, University of Chicago Pritzker School of Medicine (1999)
- Charles Dorsey Armstrong Clinical Excellence Award, Stanford University Dept. of Internal Medicine (2003)
- Clinical Excellence Award, Stanford University Division of Cardiovascular Medicine (2006)
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- Clinical Research Award, Stanford Univ. Division of Cardiovascular Medicine (2007)
- David W. Rytand Award for Excellence in Clinical Teaching by a Department of Medicine faculty member, Stanford University Department of Internal Medicine (2009, 2010)
- First Author - Selected as one of 10 most important heart failure articles in 2004, Journal of the American College of Cardiology (2005)
- First Author - Selected as one of 15 most important heart failure articles in 2007, Journal of the American College of Cardiology (2008)
- Francis G. Ebaugh, Jr. Research Award, Stanford University Dept. of Internal Medicine (2001, 2002, 2003)
- M.D. with Honors (highest distinction by U. of Chicago), University of Chicago Pritzker School of Medicine (2000)
- National Associates' Research Award, American College of Physicians/American Society of Internal Medicine (2004)
- National Research Fellowship Award, Heart Failure Society of America (2006)
- Outstanding Clinical Teaching Award, Stanford University Dept. of Internal Medicine (2002, 2003)
- Timothy F. Beckett, Jr. Award for Excellence in Teaching by a Medicine Fellow, Stanford Univ. Dept. of Internal Medicine (2006)
Administrative Appointments
- Associate Director, Coronary Care Unit (CCU) (2008 - 2009)
- Co-Director, Stanford Amyloid Center (2008 - Present)
- Co-Director, Stanford Multidisciplinary Sarcoidosis Program (2019 - Present)
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- Program Director, Internal Medicine Residency Training Program (2011 - Present)
- Sr. Associate Program Director, Internal Medicine Residency Training Program (2009 - 2011)
Publications
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Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link
Witteles, R. M., Tang, W. H. W., Jamali, A. H., Chu, J. W., Reaven, G. M., & Fowler, M. B. (2004). Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 44(1), 78–81. -
Premature ventricular contractions causing pacemaker-mediated tachycardia: A failure of postventricular atrial refractory period after premature ventricular contraction extension?
Witteles, R., Engel, G., Wang, P. J., & Al-Ahmad, A. (2005). Premature ventricular contractions causing pacemaker-mediated tachycardia: A failure of postventricular atrial refractory period after premature ventricular contraction extension? HEART RHYTHM, 2(12), 1389–90. -
Cardiomyopathy of insulin resistance.
Witteles, R. M., & Fowler, M. B. (2006). Cardiomyopathy of insulin resistance. Heart Failure Clinics, 2(1), 13–23. -
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Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial
Witteles, R. M., Kao, D., Christopherson, D., Matsuda, K., Vagelos, R. H., Schreiber, D., & Fowler, M. B. (2007). Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 50(19), 1835–40. -
Insulin-resistant cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008). Insulin-resistant cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(2), 93–102. -
Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma
Kohrt, H., Logan, A., Temmins, C., Witteles, R., Liedtke, M., & Medeiros, B. (2008). Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma. LEUKEMIA & LYMPHOMA, 49(3), 581–85. -
Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate
Telli, M. L., Witteles, R. M., Fisher, G. A., & Srinivas, S. (2008). Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. ANNALS OF ONCOLOGY, 19(9), 1613–1618. -
Clinical problem-solving. Fool's Gold.
Leeper, N. J., Dhaliwal, G., Saint, S., & Witteles, R. M. (2008). Clinical problem-solving. Fool's Gold. New England Journal of Medicine, 359(19), 2035–41. -
Heart Failure in Hispanics
Vivo, R. P., Krim, S. R., Cevik, C., & Witteles, R. M. (2009). Heart Failure in Hispanics. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(14), 1167–75. -
Nesiritide, Heart Failure, and Renal Dysfunction: Irrational Exuberance or Throwing the Baby out with the Bathwater Editorial to: "Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure" by Dontas et al.
Witteles, R. M. (2009). Nesiritide, Heart Failure, and Renal Dysfunction: Irrational Exuberance or Throwing the Baby out with the Bathwater Editorial to: "Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure" by Dontas et al. CARDIOVASCULAR DRUGS AND THERAPY, 23(3), 183–86. -
Measurement Precision in the Optimization of Cardiac Resynchronization Therapy
Turcott, R. G., Witteles, R. M., Wang, P. J., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2010). Measurement Precision in the Optimization of Cardiac Resynchronization Therapy. CIRCULATION-HEART FAILURE, 3(3), 395–404. -
Rosiglitazone Increases Myocardial Glucose Metabolism in Insulin-Resistant Cardiomyopathy
Kao, D. P., Witteles, R. M., Quon, A., Wu, J. C., Gambhir, S. S., & Fowler, M. B. (2010). Rosiglitazone Increases Myocardial Glucose Metabolism in Insulin-Resistant Cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 55(9), 926–27. -
Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies Are Clinicians Responding Optimally?
Yoon, G. J., Telli, M. L., Kao, D. P., Matsuda, K. Y., Carlson, R. W., & Witteles, R. M. (2010). Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies Are Clinicians Responding Optimally? JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(20), 1644–50. -
Radiation Therapy for Breast Cancer Buyer Beware
Witteles, R. M. (2011). Radiation Therapy for Breast Cancer Buyer Beware. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(4), 453–54. -
Trastuzumab-Related Cardiac Dysfunction
Telli, M. L., & Witteles, R. M. (2011). Trastuzumab-Related Cardiac Dysfunction. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 9(2), 243–49. -
Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented?
Witteles, R. M., Fowler, M. B., & Telli, M. L. (2011). Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented? HEART FAILURE CLINICS, 7(3), 333-? -
Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies
Varr, B. C., Liedtke, M., Arai, S., Lafayette, R. A., Schrier, S. L., & Witteles, R. M. (2012). Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 31(3), 325–31. -
Underestimating Cardiac Toxicity in Cancer Trials: Lessons Learned?
Witteles, R. M., & Telli, M. (2012). Underestimating Cardiac Toxicity in Cancer Trials: Lessons Learned? JOURNAL OF CLINICAL ONCOLOGY, 30(16), 1916–18. -
Use and overuse of left ventriculography
Witteles, R. M., Knowles, J. W., Perez, M., Morris, W. M., Spettell, C. M., Brennan, T. A., & Heidenreich, P. A. (2012). Use and overuse of left ventriculography. AMERICAN HEART JOURNAL, 163(4), 617-? -
More Than a Frog in the Throat A Case Series and Review of Localized Laryngeal Amyloidosis
Stevenson, R., Witteles, R., Damrose, E., Arai, S., Lafayette, R. A., Schrier, S., … Liedtke, M. (2012). More Than a Frog in the Throat A Case Series and Review of Localized Laryngeal Amyloidosis. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 138(5), 509–11. -
Broken Heart Syndrome (Takotsubo Cardiomyopathy) Triggered by Acute Mania: A Review and Case Report
Maldonado, J. R., Pajouhi, P., & Witteles, R. (2013). Broken Heart Syndrome (Takotsubo Cardiomyopathy) Triggered by Acute Mania: A Review and Case Report. PSYCHOSOMATICS, 54(1), 74–79. -
Capecitabine-Induced Chest Pain Relieved by Diltiazem
Ambrosy, A. P., Kunz, P. L., Fisher, G. A., & Witteles, R. M. (2012). Capecitabine-Induced Chest Pain Relieved by Diltiazem. AMERICAN JOURNAL OF CARDIOLOGY, 110(11), 1623–26. -
Dipeptidyl Peptidase 4 Inhibition Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy
Witteles, R. M., Keu, K. V., Quon, A., Tavana, H., & Fowler, M. B. (2012). Dipeptidyl Peptidase 4 Inhibition Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 18(10), 804–9. -
The prognostic value of diagnosing concurrent multiple myeloma in immunoglobulin light chain amyloidosis
Dinner, S., Witteles, W., Witteles, R., Lam, A., Arai, S., Lafayette, R., … Liedtke, M. (2013). The prognostic value of diagnosing concurrent multiple myeloma in immunoglobulin light chain amyloidosis. BRITISH JOURNAL OF HAEMATOLOGY, 161(3), 367–72. -
Cardiac Testing to Manage Cardiovascular Risk in Cancer Patients
Davis, M., & Witteles, R. M. (2013). Cardiac Testing to Manage Cardiovascular Risk in Cancer Patients. SEMINARS IN ONCOLOGY, 40(2), 147–55. -
Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement.
Dinner, S., Witteles, W., Afghahi, A., Witteles, R., Arai, S., Lafayette, R., … Liedtke, M. (2013). Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement. Haematologica, 98(10), 1593–99. -
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
Penchala, S. C., Connelly, S., Wang, Y., Park, M. S., Zhao, L., Baranczak, A., … Alhamadsheh, M. M. (2013). AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(24), 9992–97. -
B-type natriuretic peptide is effective therapy before cardiac transplantation
B-type natriuretic peptide is effective therapy before cardiac transplantation. (2004). Annals of Internal Medicine, 141(11). -
A new provocative test for the diagnosis of pheochromocytoma?
A new provocative test for the diagnosis of pheochromocytoma? (2001). American Journal of Anesthesiology, 28. -
Adult-onset nesidioblastosis causing hypoglycemia: An important clinical entity and continuing treatment dilemma
Adult-onset nesidioblastosis causing hypoglycemia: An important clinical entity and continuing treatment dilemma. (2001). Archives of Surgery, 136(6). -
Episodic hypertension associated with sitting on hard surfaces
Episodic hypertension associated with sitting on hard surfaces. (2001). Journal of General Internal Medicine, 16. -
Sensitivity of diagnostic and localization tests for pheochromocytoma in clinical practice
Sensitivity of diagnostic and localization tests for pheochromocytoma in clinical practice. (2000). Archives of Internal Medicine, 160(16). -
Safe and cost-effective preoperative preparation of patients with pheochromocytoma
Safe and cost-effective preoperative preparation of patients with pheochromocytoma. (2000). Anesthesia and Analgesia, 91(2). -
Neuroendocrine tumors of the pancreas
Neuroendocrine tumors of the pancreas. (2002). The Practice of General Surgery. -
Parathyroid carcinoma
Parathyroid carcinoma. (2002). Surgery of the Thyroid and Parathyroid Glands. -
Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well?
Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well? (2007). Journal of Clinical Oncology, 25(34). -
Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma
Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma. (2008). Leukemia and Lymphoma, 49. -
Trastuzumab cardiotoxicity: Clinical management of asymptomatic declines in left ventricular function
Trastuzumab cardiotoxicity: Clinical management of asymptomatic declines in left ventricular function. (2008). The American Journal of Hematology/Oncology, 7(1). -
High prevalence of impaired glucose metabolism in patients with idiopathic dilated cardiomyopathy
Jamali, A. H., Witteles, R. M., Tang, W. H. W., Chu, J. W., Reaven, G. M., & Fowler, M. B. (2002). High prevalence of impaired glucose metabolism in patients with idiopathic dilated cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 181A–181A. -
Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well? Reply
Telli, M. L., Carlson, R. W., Guardino, A. E., Hunt, S. A., & Witteles, R. M. (2007). Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well? Reply. JOURNAL OF CLINICAL ONCOLOGY, 25(34), 5533–34. -
Insulin resistance in chronic heart failure - Reply
Witteles, R. M., & Fowler, M. B. (2008). Insulin resistance in chronic heart failure - Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 52(3), 239–40. -
Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies: Are Clinicians Responding Appropriately?
Yoon, G., Telli, M., Kao, D., Matsuda, K., & Witteles, R. (2009). Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies: Are Clinicians Responding Appropriately? JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10), A173–A173. -
Treating Asymptomatic Chemotherapy-Induced Cardiac Dysfunction A Chance That Cardiologists and Oncologists Should Not Miss Reply
Witteles, R. M., Yoon, G., Telli, M., Kao, D. P., Matsuda, K. Y., & Carlson, R. W. (2011). Treating Asymptomatic Chemotherapy-Induced Cardiac Dysfunction A Chance That Cardiologists and Oncologists Should Not Miss Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(17), 1790–91. -
Left ventricular dysfunction in patients receiving cardiotoxic cancer therapies: Are clinicians responding appropriately?
Telli, M. L., Yoon, G., Kao, D., Matsuda, K., & Witteles, R. M. (2009). Left ventricular dysfunction in patients receiving cardiotoxic cancer therapies: Are clinicians responding appropriately? JOURNAL OF CLINICAL ONCOLOGY, 27(15). -
Overdiagnosis of Left Ventricular Noncompaction
Singh, G. D., & Witteles, R. M. (2010). Overdiagnosis of Left Ventricular Noncompaction. JOURNAL OF CARDIAC FAILURE, 16(8), S107–S107. -
OVERUSE OF LEFT VENTRICULOGRAPHY
Witteles, R., Knowles, J. W., Perez, M., Morris, W. H., Spettell, C. M., Brennan, T. A., & Heidenreich, P. A. (2011). OVERUSE OF LEFT VENTRICULOGRAPHY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E1289–E1289. -
Cardiac Amyloidosis: Screening Criteria for Heart Transplantation and New Strategies for Post-Transplant Therapy
Varr, B. C., Liedtke, M., Arai, S., Lafayette, R. A., Schrier, S. L., & Witteles, R. M. (2011). Cardiac Amyloidosis: Screening Criteria for Heart Transplantation and New Strategies for Post-Transplant Therapy. JOURNAL OF CARDIAC FAILURE, 17(8), S45–S46. -
A Pilot Study of Melphalan, Lenalidomide and Dexamethasone In AL Amyloidosis: Interim Results
Afghahi, A., Witteles, W., Witteles, R., Liedtke, M., Lafayette, R., Arai, S., & Schrier, S. L. (2010). A Pilot Study of Melphalan, Lenalidomide and Dexamethasone In AL Amyloidosis: Interim Results. BLOOD, 116(21), 810–11. -
Incidence and severity of cardiotoxicity in metastatic renal cell carcinoma (RCC) patients treated with targeted therapies.
Hall, P. S., Witteles, R., Srinivas, S., & Harshman, L. C. (2012). Incidence and severity of cardiotoxicity in metastatic renal cell carcinoma (RCC) patients treated with targeted therapies. JOURNAL OF CLINICAL ONCOLOGY, 30(15). -
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
Esler, M. D., Krum, H., Sobotka, P. A., Schlaich, M. P., Schmieder, R. E., Boehm, M., … Massaro, J. M. (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. LANCET, 376(9756), 1903–9. -
Implantable cardioverter-defibrillator placement in patients with cardiac amyloidosis
Varr, B. C., Zarafshar, S., Coakley, T., Liedtke, M., Lafayette, R. A., Arai, S., … Witteles, R. M. (2014). Implantable cardioverter-defibrillator placement in patients with cardiac amyloidosis. HEART RHYTHM, 11(1), 158–62. -
Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System
Heidenreich, P. A., Lin, S., Knowles, J. W., Perez, M., Maddox, T. M., Ho, M. P., … Witteles, R. M. (2013). Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 6(6), 687–93. -
The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients.
Hall, P. S., Harshman, L. C., Srinivas, S., & Witteles, R. M. (2013). The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients. JACC. Heart Failure, 1(1), 72–78. -
Cancer therapy-induced left ventricular dysfunction: interventions and prognosis.
Thakur, A., & Witteles, R. M. (2014). Cancer therapy-induced left ventricular dysfunction: interventions and prognosis. Journal of Cardiac Failure, 20(3), 155–58. -
Radiation-induced heart disease: an under-recognized entity?
Davis, M., & Witteles, R. M. (2014). Radiation-induced heart disease: an under-recognized entity? Current Treatment Options in Cardiovascular Medicine, 16(6), 317-? -
Reply to "heart failure and breast cancer: emerging controversies regarding some cardioprotective strategies".
Witteles, R. M., & Thakur, A. (2014). Reply to "heart failure and breast cancer: emerging controversies regarding some cardioprotective strategies". Journal of Cardiac Failure, 20(6), 457-? -
Outcomes after heart transplantation for amyloid cardiomyopathy in the modern era.
Davis, M. K., Kale, P., Liedtke, M., Schrier, S., Arai, S., Wheeler, M., … Witteles, R. M. (2015). Outcomes after heart transplantation for amyloid cardiomyopathy in the modern era. American Journal of Transplantation , 15(3), 650–58. -
Changing outcomes after heart transplantation in patients with amyloid cardiomyopathy
Davis, M. K., Lee, P. H. U., & Witteles, R. M. (2015). Changing outcomes after heart transplantation in patients with amyloid cardiomyopathy. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 34(5), 658–66. -
The State of Medical Student Performance Evaluations: Improved Transparency or Continued Obfuscation?
Hom, J., Richman, I., Hall, P., Ahuja, N., Harman, S., Harrington, R., & Witteles, R. (2016). The State of Medical Student Performance Evaluations: Improved Transparency or Continued Obfuscation? Academic Medicine , 91(11), 1534–39. -
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
Burridge, P. W., Li, Y. F., Matsa, E., Wu, H., Ong, S.-G., Sharma, A., … Wu, J. C. (2016). Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. NATURE MEDICINE, 22(5), 547–56. -
Patient Outcomes when Housestaff Exceed 80 Hours per Week.
Ouyang, D., Chen, J. H., Krishnan, G., Hom, J., Witteles, R., & Chi, J. (2016). Patient Outcomes when Housestaff Exceed 80 Hours per Week. American Journal of Medicine, 129(9), 993–99 e1. -
A resident-created hospitalist curriculum for internal medicine housestaff.
Kumar, A., Smeraglio, A., Witteles, R., Harman, S., Nallamshetty, S., Rogers, A., … Ahuja, N. (2016). A resident-created hospitalist curriculum for internal medicine housestaff. Journal of Hospital Medicine, 11(9), 646–49. -
Genotype and Phenotype of Transthyretin Cardiac Amyloidosis THAOS (Transthyretin Amyloid Outcome Survey)
Maurer, M. S., Hanna, M., Grogan, M., Dispenzieri, A., Witteles, R., Drachman, B., … Rapezzi, C. (2016). Genotype and Phenotype of Transthyretin Cardiac Amyloidosis THAOS (Transthyretin Amyloid Outcome Survey). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(2), 161–72. -
Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies
Witteles, R. M. (2016). Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies. JOURNAL OF CARDIAC FAILURE, 22(6), 459–64. -
Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey).
Maurer, M. S., Hanna, M., Grogan, M., Dispenzieri, A., Witteles, R., Drachman, B., … Rapezzi, C. (2016). Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). Journal of the American College of Cardiology, 68(2), 161–72. -
The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients
Hall, P. S., Harshman, L. C., Srinivas, S., & Witteles, R. M. (2013). The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients. JACC-HEART FAILURE, 1(1), 72–78. -
Accreditation Council for Graduate Medical Education (ACGME) Milestones-Time for a Revolt?
Witteles, R. M., & Verghese, A. (2016). Accreditation Council for Graduate Medical Education (ACGME) Milestones-Time for a Revolt? JAMA Internal Medicine, 176(11), 1599–1600. -
A high value care curriculum for interns: a description of curricular design, implementation and housestaff feedback.
Hom, J., Kumar, A., Evans, K. H., Svec, D., Richman, I., Fang, D., … Shieh, L. (2017). A high value care curriculum for interns: a description of curricular design, implementation and housestaff feedback. Postgraduate Medical Journal. -
Functional Cardiac Recovery and Hematologic Response to Chemotherapy in Patients With Light-Chain Amyloidosis (from the Stanford University Amyloidosis Registry).
Tuzovic, M., Kobayashi, Y., Wheeler, M., Barrett, C., Liedtke, M., Lafayette, R., … Witteles, R. (2017). Functional Cardiac Recovery and Hematologic Response to Chemotherapy in Patients With Light-Chain Amyloidosis (from the Stanford University Amyloidosis Registry). The American Journal of Cardiology, 120(8), 1381–86. -
A 15-year review of the Stanford Internal Medicine Residency Program: predictors of resident satisfaction and dissatisfaction
Kahn, J. S., Witteles, R. M., Mahaffey, K. W., Desai, S. A., Ozdalga, E., & Heidenreich, P. A. (2017). A 15-year review of the Stanford Internal Medicine Residency Program: predictors of resident satisfaction and dissatisfaction. ADVANCES IN MEDICAL EDUCATION AND PRACTICE, 8, 559–66. -
Independent AV/VV pacing optimization requires operation along mechanical AV delay isochrones
Turcott, R. G., Witteles, R., Wang, P. J., & Ashley, E. A. (2008). Independent AV/VV pacing optimization requires operation along mechanical AV delay isochrones. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10), A21. -
Impedance cardiography is superior to echocardiographic methods for pacing interval optimization
Turcott, R. G., Witteles, R. M., Wang, P. J., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2008). Impedance cardiography is superior to echocardiographic methods for pacing interval optimization. JOURNAL OF CARDIAC FAILURE, 14(6), S65. -
AL Amyloidosis and Concomitant Myeloma: Time to Reconsider Assumptions.
Witteles, W., Witteles, R., Liedtke, M., Arai, S., Lafayette, R., George, T. I., & Schrier, S. L. (2010). AL Amyloidosis and Concomitant Myeloma: Time to Reconsider Assumptions. BLOOD. AMER SOC HEMATOLOGY. -
Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis
Kaufman, G. P., Schrier, S. L., Lafayette, R. A., Arai, S., Witteles, R. M., & Liedtke, M. (2017). Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis. BLOOD, 130(7), 900–902. -
SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE
Ning, N., Guo, H. H., Jagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2018). SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71(11), 1690. -
Atrial Septal Defect as Unexpected Cause of Pulmonary Artery Hypertension
Parikh, R., Boyd, J., Lee, D. P., & Witteles, R. (2018). Atrial Septal Defect as Unexpected Cause of Pulmonary Artery Hypertension. TEXAS HEART INSTITUTE JOURNAL, 45(1), 42–44. -
Carcinoid Syndrome Complicating a Pancreatic Neuroendocrine Tumor A Case Report
Gerson, J. N., Witteles, R. M., Chang, D. T., Beygui, R. E., Iagaru, A. H., & Kunz, P. L. (2017). Carcinoid Syndrome Complicating a Pancreatic Neuroendocrine Tumor A Case Report. PANCREAS, 46(10), 1381–85. -
18F-florbetaben whole-body PET/MRI for evaluation of systemic amyloid deposition.
Baratto, L., Park, S. Y., Hatami, N., Gulaka, P., Vasanawala, S., Yohannan, T. K., … Iagaru, A. (2018). 18F-florbetaben whole-body PET/MRI for evaluation of systemic amyloid deposition. EJNMMI Research, 8(1), 66. -
Epidemiology and Clinical Implications of Gastrointestinal Symptoms in Systemic Amyloidosis
Yen, T., Chen, F., Witteles, R., Liedtke, M., & Nguyen, L. A. (2017). Epidemiology and Clinical Implications of Gastrointestinal Symptoms in Systemic Amyloidosis. AMERICAN JOURNAL OF GASTROENTEROLOGY. NATURE PUBLISHING GROUP. -
Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy.
Maurer, M. S., Schwartz, J. H., Gundapaneni, B., Elliott, P. M., Merlini, G., Waddington-Cruz, M., … Rapezzi, C. (2018). Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. The New England Journal of Medicine. -
WHOLE HEART OF THE MATTER
Parikh, R., Boyd, J., Lee, D., & Witteles, R. (2017). WHOLE HEART OF THE MATTER. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
Prevalence and Financial Impact of Inappropriate Thrombophilia Testing in the Inpatient Hospital Setting: A Retrospective Analysis
Mou, E., Kwang, H., Hom, J., Shieh, L., Ahuja, N., Harman, S., … Berube, C. (2016). Prevalence and Financial Impact of Inappropriate Thrombophilia Testing in the Inpatient Hospital Setting: A Retrospective Analysis. BLOOD. AMER SOC HEMATOLOGY. -
The State of Medical Student Performance Evaluations: Improved Transparency or Continued Obfuscation?
Hom, J., Richman, I., Hall, P., Ahuja, N., Harman, S., Harrington, R., & Witteles, R. (2016). The State of Medical Student Performance Evaluations: Improved Transparency or Continued Obfuscation? ACADEMIC MEDICINE, 91(11), 1534–39. -
Hematologic Responses and Cardiac Organ Improvement in Patients with Heavily Pretreated Cardiac Immunoglobulin Light Chain (AL) Amyloidosis Receiving Daratumumab
Kaufman, G., Witteles, R., Wheeler, M., Ulloa, P., Lugtu, M., Arai, S., … Liedtke, M. (2016). Hematologic Responses and Cardiac Organ Improvement in Patients with Heavily Pretreated Cardiac Immunoglobulin Light Chain (AL) Amyloidosis Receiving Daratumumab. BLOOD. AMER SOC HEMATOLOGY. -
Grading cardiac response in AL amyloidosis: implications for relapse and survival.
Eckhert, E., Witteles, R., Kaufman, G., Lafayette, R., Arai, S., Schrier, S., … Liedtke, M. (2018). Grading cardiac response in AL amyloidosis: implications for relapse and survival. British Journal of Haematology. -
Efficacy of Tafamidis in Transthyretin Amyloid Cardiomyopathy in the ATTR-ACT Trial: Sensitivity Analyses Further Support the Primary Results
Maurer, M. S., Schwartz, J. H., Gundapaneni, B., Elliott, P., Merlini, G., Cruz, M. W., … Rapezzi, C. (2018). Efficacy of Tafamidis in Transthyretin Amyloid Cardiomyopathy in the ATTR-ACT Trial: Sensitivity Analyses Further Support the Primary Results. JOURNAL OF CARDIAC FAILURE, 24(11), 813. -
Safety, Tolerability and Transthyretin Stabilization by AG10: A Phase 2, Randomized, Double-blind, Placebo-controlled Clinical Trial in Patients with Transthyretin Amyloid Cardiomyopathy and NYHA Class II/III Heart Failure
Judge, D. P., Falk, R., Grogan, M., Heitner, S. B., Jacoby, D., Maurer, M., … Fox, J. C. (2018). Safety, Tolerability and Transthyretin Stabilization by AG10: A Phase 2, Randomized, Double-blind, Placebo-controlled Clinical Trial in Patients with Transthyretin Amyloid Cardiomyopathy and NYHA Class II/III Heart Failure. CIRCULATION, 138(25), E770. -
Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time.
Witteles, R. (2019). Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time. Journal of Cardiac Failure. -
Graded Cardiac Response Correlates with Relapse and Survival in AL Amyloidosis
Eckhert, E. K., Witteles, R., Kaufman, G., Lafayette, R., Arai, S., Schrier, S., … Liedtke, M. (2018). Graded Cardiac Response Correlates with Relapse and Survival in AL Amyloidosis. BLOOD, 132. -
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis.
Ning, N., Guo, H. H., Iagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2019). Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis. Journal of Cardiac Failure. -
Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients.
Kitani, T., Ong, S.-G. G., Lam, C. K., Rhee, J.-W. W., Zhang, J. Z., Oikonomopoulos, A., … Wu, J. C. (2019). Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients. Circulation. -
REPLY: Increasingly Recognized Role of Right Ventricle Assessment in Cardiac Amyloidosis
Amsallem, M., Witteles, R., & Haddad, F. (2019). REPLY: Increasingly Recognized Role of Right Ventricle Assessment in Cardiac Amyloidosis. JACC-HEART FAILURE, 7(3), 279–80. -
Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy.
Judge, D. P., Falk, R. H., Maurer, M. S., Shah, S. J., Witteles, R. M., Grogan, M., … Heitner, S. B. (2019). Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy. Journal of the American College of Cardiology. -
Nesiritide does not cause renal dysfunction in acute decompensated heart failure: A randomized, double-blind, placebo-controlled clinical trial
Witteles, R. M., Kao, D., Vagelos, R., Christopherson, D., Matsuda, K., Schreiber, D., & Fowler, M. B. (2007). Nesiritide does not cause renal dysfunction in acute decompensated heart failure: A randomized, double-blind, placebo-controlled clinical trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(9), 63A. -
B-type natriuretic peptide is effective therapy before care
Witteles, R., Matsuda, K., & Fowler, M. B. (2004). B-type natriuretic peptide is effective therapy before care. ANNALS OF INTERNAL MEDICINE, 141(11), 895. -
FROM PALPITATIONS TO CARDIOVASCULAR COLLAPSE: THE STORY OF A PHEOCHROMOCYTOMA
Flint, K. M., & Witteles, R. (2015). FROM PALPITATIONS TO CARDIOVASCULAR COLLAPSE: THE STORY OF A PHEOCHROMOCYTOMA. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10), A618. -
Response to Letter Regarding Article, "Myocardial Protection During Cardiotoxic Chemotherapy"
Witteles, R. M., & Bosch, X. (2016). Response to Letter Regarding Article, "Myocardial Protection During Cardiotoxic Chemotherapy". CIRCULATION, 133(15), E598. -
Myocardial Protection During Cardiotoxic Chemotherapy
Witteles, R. M., & Bosch, X. (2015). Myocardial Protection During Cardiotoxic Chemotherapy. CIRCULATION, 132(19), 1835–45. -
Development of a reproducible FDG PET/CT cardiac imaging protocol for the evaluation of cardiac sarcoidosis
Kulm, J., Mittra, E., Guo, H. H., Witteles, R., & Quon, A. (2013). Development of a reproducible FDG PET/CT cardiac imaging protocol for the evaluation of cardiac sarcoidosis. JOURNAL OF NUCLEAR MEDICINE, 54. -
Chemotherapy-Induced Left Ventricular Dysfunction: Interventions and Prognosis
Thakur, A., & Witteles, R. M. (2013). Chemotherapy-Induced Left Ventricular Dysfunction: Interventions and Prognosis. JOURNAL OF CARDIAC FAILURE, 19(8), S86–S87. -
Therapy With a DPP-4 Inhibitor Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy
Witteles, R. M., Keu, K. V., Quon, A., Tavana, H., & Fowler, M. B. (2012). Therapy With a DPP-4 Inhibitor Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 18(8), S10. -
Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy
Maurer, M. S., Schwartz, J. H., Gundapaneni, B., Elliott, P. M., Merlini, G., Waddington-Cruz, M., … Rapezzi, C. (2018). Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. NEW ENGLAND JOURNAL OF MEDICINE, 379(11), 1007–16. -
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis
Ning, N., Guo, H. H., Iagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2019). Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis. JOURNAL OF CARDIAC FAILURE, 25(4), 307–11. -
Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time
Witteles, R. M. (2019). Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time. JOURNAL OF CARDIAC FAILURE, 25(3), 154–55. -
F-18-florbetaben whole-body PET/MRI for evaluation of systemic amyloid deposition
Baratto, L., Park, S. Y., Hatami, N., Gulaka, P., Vasanawala, S., Yohannan, T. K., … Iagaru, A. (2018). F-18-florbetaben whole-body PET/MRI for evaluation of systemic amyloid deposition. EJNMMI RESEARCH, 8. -
A high value care curriculum for interns: a description of curricular design, implementation and housestaff feedback
Hom, J., Kumar, A., Evans, K. H., Svec, D., Richman, I., Fang, D., … Shieh, L. (2017). A high value care curriculum for interns: a description of curricular design, implementation and housestaff feedback. POSTGRADUATE MEDICAL JOURNAL, 93(1106), 725–29. -
Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., … Wu, J. C. (2019). Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer. CIRCULATION, 139(21), 2451–65. -
Grading cardiac response in AL amyloidosis: implications for relapse and survival
Eckhert, E., Witteles, R., Kaufman, G., Lafayette, R., Arai, S., Schrier, S., … Liedtke, M. (2019). Grading cardiac response in AL amyloidosis: implications for relapse and survival. BRITISH JOURNAL OF HAEMATOLOGY, 186(1), 144–46. -
Emerging Therapies for Transthyretin Cardiac Amyloidosis.
Alexander, K. M., Evangelisti, A., & Witteles, R. M. (2019). Emerging Therapies for Transthyretin Cardiac Amyloidosis. Current Treatment Options in Cardiovascular Medicine, 21(8), 40. -
Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice.
Witteles, R. M., Bokhari, S., Damy, T., Elliott, P. M., Falk, R. H., Fine, N. M., … Garcia-Pavia, P. (2019). Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice. JACC. Heart Failure. -
Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy
Judge, D. P., Heitner, S. B., Falk, R. H., Maurer, M. S., Shah, S. J., Witteles, R. M., … Fox, J. C. (2019). Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 74(3), 285–95. -
Thrombophilia testing in the inpatient setting: impact of an educational intervention.
Kwang, H., Mou, E., Richman, I., Kumar, A., Berube, C., Kaimal, R., … Hom, J. (2019). Thrombophilia testing in the inpatient setting: impact of an educational intervention. BMC Medical Informatics and Decision Making, 19(1), 167. -
Genomics in medicine: a novel elective rotation for internal medicine residents.
Geng, L. N., Kohler, J. N., Levonian, P., Bernstein, J. A., Ford, J. M., Ahuja, N., … Wheeler, M. (2019). Genomics in medicine: a novel elective rotation for internal medicine residents. Postgraduate Medical Journal. -
Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis.
Maurer, M. S., Bokhari, S., Damy, T., Dorbala, S., Drachman, B. M., Fontana, M., … Merlini, G. (2019). Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis. Circulation. Heart Failure, 12(9), e006075. -
Efficacy and Safety of Tafamidis Doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT)
Hanna, M., Damy, T., Garcia-Pavia, P., Judge, D. P., Merlini, G., Maurer, M. S., … Witteles, R. (2019). Efficacy and Safety of Tafamidis Doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT). JOURNAL OF CARDIAC FAILURE, 25(8), S77–S78. -
Diagnosis and Treatment of Cardiac Amyloidosis Related to Plasma Cell Dyscrasias.
Alexander, K. M., Evangelisti, A., & Witteles, R. M. (2019). Diagnosis and Treatment of Cardiac Amyloidosis Related to Plasma Cell Dyscrasias. Cardiology Clinics, 37(4), 487–95. -
A Changing Landscape of Mortality for Systemic Light Chain Amyloidosis.
Barrett, C. D., Dobos, K., Liedtke, M., Tuzovic, M., Haddad, F., Kobayashi, Y., … Witteles, R. M. (2019). A Changing Landscape of Mortality for Systemic Light Chain Amyloidosis. JACC. Heart Failure. -
TNF-alpha inhibition for the treatment of cardiac sarcoidosis.
Baker, M. C., Sheth, K., Witteles, R., Genovese, M. C., Shoor, S., & Simard, J. F. (2019). TNF-alpha inhibition for the treatment of cardiac sarcoidosis. Seminars in Arthritis and Rheumatism. -
Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Still Much to Learn.
Alexander, K. M., & Witteles, R. M. (2020). Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Still Much to Learn. JACC. Cardiovascular Imaging. -
Long-Term Safety and Efficacy of AG10 in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM): Interim Analysis of the Ongoing Phase 2 Open-Label Extension Study
Judge, D., Heitner, S. B., Falk, R. H., Grogan, M., Jacoby, D. L., Maurer, M. S., … Fox, J. (2019). Long-Term Safety and Efficacy of AG10 in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM): Interim Analysis of the Ongoing Phase 2 Open-Label Extension Study. CIRCULATION, 140(25), E966–E967. -
Organ responses with daratumumab therapy in previously treated AL amyloidosis.
Chung, A., Kaufman, G. P., Sidana, S., Eckhert, E., Schrier, S. L., Lafayette, R. A., … Liedtke, M. (2020). Organ responses with daratumumab therapy in previously treated AL amyloidosis. Blood Advances, 4(3), 458–66. -
Management of Cardiac Amyloidosis: Do's and Don'ts.
Alexander, K. M., & Witteles, R. M. (2019). Management of Cardiac Amyloidosis: Do's and Don'ts. The Canadian Journal of Cardiology. -
Human-induced Pluripotent Stem Cell-derived Cardiomyocytes as a Model for Trastuzumab-Induced Cardiac Dysfunction
Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., … Wu, J. C. (2019). Human-induced Pluripotent Stem Cell-derived Cardiomyocytes as a Model for Trastuzumab-Induced Cardiac Dysfunction. CIRCULATION RESEARCH. LIPPINCOTT WILLIAMS & WILKINS. -
Portable Ultrasound Device Usage and Learning Outcomes Among Internal Medicine Trainees: A Parallel-Group Randomized Trial.
Kumar, A., Weng, Y., Wang, L., Bentley, J., Almli, M., Hom, J., … Kugler, J. (2020). Portable Ultrasound Device Usage and Learning Outcomes Among Internal Medicine Trainees: A Parallel-Group Randomized Trial. Journal of Hospital Medicine, 15(2), e1–e6. -
Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response
Zhu, H., Rhee, J.-W., Cheng, P., Waliany, S., Chang, A., Witteles, R. M., … Wu, S. M. (2020). Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response. Curr Cardiol Rep, 22(5). -
Cardiovascular Risks in Patients with COVID-19: Potential Mechanisms and Areas of Uncertainty.
Cheng, P., Zhu, H., Witteles, R. M., Wu, J. C., Quertermous, T., Wu, S. M., & Rhee, J.-W. W. (2020). Cardiovascular Risks in Patients with COVID-19: Potential Mechanisms and Areas of Uncertainty. Current Cardiology Reports, 22(5), 34. -
Outcomes in Patients With Cardiac Amyloidosis Undergoing Heart Transplantation.
Barrett, C. D., Alexander, K. M., Zhao, H., Haddad, F., Cheng, P., Liao, R., … Witteles, R. M. (2020). Outcomes in Patients With Cardiac Amyloidosis Undergoing Heart Transplantation. JACC. Heart Failure. -
Correction to: Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response.
Zhu, H., Rhee, J.-W., Cheng, P., Waliany, S., Chang, A., Witteles, R. M., … Wu, S. M. (2020). Correction to: Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response. Current Cardiology Reports, 22(5), 36. -
Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a Position Statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society.
Lyon, A. R., Dent, S., Stanway, S., Earl, H., Brezden-Masley, C., Cohen-Solal, A., … Lenihan, D. (2020). Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a Position Statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. European Journal of Heart Failure. -
Cardiac Scintigraphy With Technetium-99m-Labeled Bone-Seeking Tracers for Suspected Amyloidosis: JACC Review Topic of the Week.
Hanna, M., Ruberg, F. L., Maurer, M. S., Dispenzieri, A., Dorbala, S., Falk, R. H., … Grogan, M. (2020). Cardiac Scintigraphy With Technetium-99m-Labeled Bone-Seeking Tracers for Suspected Amyloidosis: JACC Review Topic of the Week. Journal of the American College of Cardiology, 75(22), 2851–62. -
Cardiac Scintigraphy With Technetium-99m-Labeled Bone -Seeking Tracers for Suspected Amyloidosis JACC Review Topic of the Week
Hanna, M., Ruberg, F. L., Maurer, M. S., Dispenzieri, A., Dorbala, S., Falk, R. H., … Grogan, M. (2020). Cardiac Scintigraphy With Technetium-99m-Labeled Bone -Seeking Tracers for Suspected Amyloidosis JACC Review Topic of the Week. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75(22), 2851–62. -
Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure.
Waliany, S., Lee, D., Witteles, R. M., Neal, J. W., Nguyen, P., Davis, M. M., … Zhu, H. (2020). Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure. Annual Review of Pharmacology and Toxicology. -
REPLY: Should We Be for ASCT? If Yes, Then When?
Witteles, R. M., & Barrett, C. D. (2020). REPLY: Should We Be for ASCT? If Yes, Then When? JACC-HEART FAILURE, 8(8), 696–97. -
Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner.
Gertz, M., Adams, D., Ando, Y., Beirão, J. M., Bokhari, S., Coelho, T., … Merlini, G. (2020). Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner. BMC Family Practice, 21(1), 198. -
A pilot study of F-18-FSPG SiPM-based PET/CT in patients referred for exclusion of active cardiac sarcoidosis and negative or non-diagnostic F-18-FDG PET/CT
Duan, H., Hatami, N., Baratto, L., Davidzon, G., Aparici, C. M., Gambhir, S., … Iagaru, A. (2020). A pilot study of F-18-FSPG SiPM-based PET/CT in patients referred for exclusion of active cardiac sarcoidosis and negative or non-diagnostic F-18-FDG PET/CT. JOURNAL OF NUCLEAR MEDICINE, 61. -
Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study.
Damy, T., Garcia-Pavia, P., Hanna, M., Judge, D. P., Merlini, G., Gundapaneni, B., … Witteles, R. (2020). Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study. European Journal of Heart Failure. -
Functional Capacity, Health-related Quality-of-life and Cardiac Biomarker Improvement with Tafamidis in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT)
Hanna, M., Fine, N., Stewart, M., Gundapaneni, B., Sultan, M. B., & Witteles, R. (2020). Functional Capacity, Health-related Quality-of-life and Cardiac Biomarker Improvement with Tafamidis in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT). JOURNAL OF CARDIAC FAILURE, 26(10), S65. -
Temporal Trends of Wild-type Attr Amyloidosis in the Transthyretin Amyloidosis Outcomes Survey
Nativi-Nicolau, J., Siu, A., Dispenzieri, A., Maurer, M. S., Rapezzi, C., Kristen, A., … Grogan, M. (2020). Temporal Trends of Wild-type Attr Amyloidosis in the Transthyretin Amyloidosis Outcomes Survey. JOURNAL OF CARDIAC FAILURE, 26(10), S82. -
Letter regarding the article 'Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study'.
Damy, T., Sultan, M. B., & Witteles, R. (2020). Letter regarding the article 'Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study'. European Journal of Heart Failure. -
Long-Term Outcomes and Organ Responses with Daratumumab Therapy in Previously Treated Patients with AL Amyloidosis
Chung, A., Kaufman, G. P., Sidana, S., Eckhert, E., Schrier, S., Arai, S., … Liedtke, M. (2019). Long-Term Outcomes and Organ Responses with Daratumumab Therapy in Previously Treated Patients with AL Amyloidosis. BLOOD. AMER SOC HEMATOLOGY. -
Favorable Long-Term Outcomes after Daratumumab Discontinuation in AL Amyloidosis Patients Achieving Deep Responses
Chung, A., Kaufman, G. P., Sidana, S., Iberri, D., Eckhert, E., Schrier, S., … Liedtke, M. (2019). Favorable Long-Term Outcomes after Daratumumab Discontinuation in AL Amyloidosis Patients Achieving Deep Responses. BLOOD. AMER SOC HEMATOLOGY. -
Global Longitudinal Strain in Cardio-Oncology.
Moslehi, J. J., & Witteles, R. M. (2021). Global Longitudinal Strain in Cardio-Oncology. Journal of the American College of Cardiology, 77(4), 402–4. -
Immune Profiling and Causal Antigen Discovery in Mouse and Human Models of Immune Checkpoint Inhibitor-induced Myocarditis
Zhu, H., Lee, D., Sarah, W., Galdos, F. X., D'Addabbo, J., Fowler, M. B., … Wu, S. M. (2020). Immune Profiling and Causal Antigen Discovery in Mouse and Human Models of Immune Checkpoint Inhibitor-induced Myocarditis. CIRCULATION RESEARCH. LIPPINCOTT WILLIAMS & WILKINS. -
AL Amyloidosis for the Cardiologist and Oncologist Epidemiology, Diagnosis, and Management
Witteles, R. M., & Liedtke, M. (2019). AL Amyloidosis for the Cardiologist and Oncologist Epidemiology, Diagnosis, and Management. JACC: CARDIOONCOLOGY, 1(1), 117–30. -
Increase in Blood Pressure Associated With Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor
Waliany, S., Sainani, K. L., Park, L. S., Zhang, C. A., Srinivas, S., & Witteles, R. M. (2019). Increase in Blood Pressure Associated With Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor. JACC: CARDIOONCOLOGY, 1(1), 24–36. -
Avoiding Catastrophe: Understanding Free Light Chain Testing in the Evaluation of ATTR Amyloidosis.
Witteles, R. M., & Liedtke, M. (2021). Avoiding Catastrophe: Understanding Free Light Chain Testing in the Evaluation of ATTR Amyloidosis. Circulation. Heart Failure, CIRCHEARTFAILURE120008225. -
Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis
Spencer-Bonilla, G., Njoroge, J. N., Pearson, K., Witteles, R. M., Aras, M. A., & Alexander, K. M. (2021). Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Curr Cardiovasc Risk Rep. -
Myocarditis Surveillance with High-Sensitivity Troponin I During Cancer Treatment with Immune Checkpoint Inhibitors.
Waliany, S., Neal, J. W., Reddy, S., Wakelee, H., Shah, S. A., Srinivas, S., … Zhu, H. (2021). Myocarditis Surveillance with High-Sensitivity Troponin I During Cancer Treatment with Immune Checkpoint Inhibitors. JACC. CardioOncology, 3(1), 137–39. -
Corrigendum to 'TNF-alpha Inhibition for the Treatment of Cardiac Sarcoidosis' Seminars in Arthritis and Rheumatism. 2020 Jun;50(3):546-552.
Baker, M. C., Sheth, K., Witteles, R., Genovese, M. C., Shoor, S., & Simard, J. F. (2021). Corrigendum to 'TNF-alpha Inhibition for the Treatment of Cardiac Sarcoidosis' Seminars in Arthritis and Rheumatism. 2020 Jun;50(3):546-552. Seminars in Arthritis and Rheumatism. -
Racial and Ethnic Disparities in Cardio-Oncology A Call to Action
Fazal, M., Malisa, J., Rhee, J.-W., Witteles, R. M., & Rodriguez, F. (2021). Racial and Ethnic Disparities in Cardio-Oncology A Call to Action. JACC: CARDIOONCOLOGY, 3(2), 201–204. -
Racial and Ethnic Disparities in Cardio-Oncology: A Call to Action.
Fazal, M., Malisa, J., Rhee, J.-W. W., Witteles, R. M., & Rodriguez, F. (2021). Racial and Ethnic Disparities in Cardio-Oncology: A Call to Action. JACC. CardioOncology, 3(2), 201–204. -
Increase in Blood Pressure Associated With Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor.
Waliany, S., Sainani, K. L., Park, L. S., Zhang, C. A., Srinivas, S., & Witteles, R. M. (2019). Increase in Blood Pressure Associated With Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor. JACC. CardioOncology, 1(1), 24–36. -
AL Amyloidosis for the Cardiologist and Oncologist: Epidemiology, Diagnosis, and Management.
Witteles, R. M., & Liedtke, M. (2019). AL Amyloidosis for the Cardiologist and Oncologist: Epidemiology, Diagnosis, and Management. JACC. CardioOncology, 1(1), 117–130. -
Pharmacovigilance analysis of cardiac toxicities associated with targeted therapies for metastatic non-small cell lung carcinoma.
Waliany, S., Zhu, H., Wakelee, H., Padda, S. K., Das, M., Ramchandran, K., … Neal, J. W. (2021). Pharmacovigilance analysis of cardiac toxicities associated with targeted therapies for metastatic non-small cell lung carcinoma. Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. -
Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
O'Brien, C. G., Ozen, M. O., Ikeda, G., Vaskova, E., Jung, J. H., Bayardo, N., … Yang, P. C. (2021). Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial. JACC. CardioOncology, 3(3), 428–440. -
Misconceptions and Facts About Cardiac Amyloidosis.
Nguyen, F. D., Rodriguez Rivera, M., Krittanawong, C., Witteles, R., & Lenihan, D. J. (2021). Misconceptions and Facts About Cardiac Amyloidosis. The American Journal of Cardiology. -
Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey.
Nativi-Nicolau, J., Siu, A., Dispenzieri, A., Maurer, M. S., Rapezzi, C., Kristen, A. V., … Grogan, M. (2021). Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey. JACC. CardioOncology, 3(4), 537–546. -
Cardiac Transplantation and Mechanical Circulatory Support in Amyloidosis.
Witteles, R. M. (2021). Cardiac Transplantation and Mechanical Circulatory Support in Amyloidosis. JACC. CardioOncology, 3(4), 516–521. -
Graded renal response criteria and revised renal progression criteria for light chain (AL) amyloidosis
Muchtar, E., Wisniowski, B., Palladini, G., Milani, P., Merlini, G., Schonland, S., … Gertz, M. (2021). Graded renal response criteria and revised renal progression criteria for light chain (AL) amyloidosis. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
Ibrutinib-associated atrial fibrillation treatment with catheter ablation.
Kapoor, R., Fazal, M., Cheng, P., Witteles, R., Rhee, J.-W., & Baykaner, T. (2021). Ibrutinib-associated atrial fibrillation treatment with catheter ablation. HeartRhythm Case Reports, 7(11), 713–716. -
Graded cardiac response criteria for AL amyloidosis: the impact of depth of cardiac response on survival
Muchtar, E. Y., Dispenzieri, A., Wisniowski, B., Palladini, G., Milani, P., Merlini, G., … Gertz, M. (2021). Graded cardiac response criteria for AL amyloidosis: the impact of depth of cardiac response on survival. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
Arrhythmia Patterns in Patients on Ibrutinib.
Fazal, M., Kapoor, R., Cheng, P., Rogers, A. J., Narayan, S. M., Wang, P., … Rhee, J.-W. (1800). Arrhythmia Patterns in Patients on Ibrutinib. Frontiers in Cardiovascular Medicine, 8, 792310. -
Developing Therapy for Transthyretin Amyloidosis.
Campbell, C. M., Zhang, K., Lenihan, D. J., & Witteles, R. (1800). Developing Therapy for Transthyretin Amyloidosis. The American Journal of Medicine. -
High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning.
Duffy, G., Cheng, P. P., Yuan, N., He, B., Kwan, A. C., Shun-Shin, M. J., … Ouyang, D. (2022). High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning. JAMA Cardiology. -
Constrictive Pericarditis Revealing Rare Case of ALH Amyloidosis With Underlying Lymphoplasmacytic Lymphoma (Waldenstrom Macroglobulinemia).
Ho, V. V., O'Sullivan, J. W., Collins, W. J., Ozdalga, E., Bell, C. F., Shah, N. D., … Witteles, R. M. (2022). Constrictive Pericarditis Revealing Rare Case of ALH Amyloidosis With Underlying Lymphoplasmacytic Lymphoma (Waldenstrom Macroglobulinemia). JACC. Case Reports, 4(5), 271–275. -
Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis.
Spencer-Bonilla, G., Njoroge, J. N., Pearson, K., Witteles, R. M., Aras, M. A., & Alexander, K. M. (2021). Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports, 15(6). -
The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity
Huang, Y. V., Waliany, S., Lee, D., Galdos, F. X., Witteles, R. M., Neal, J. W., … Zhu, H. (2022). The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity. JACC: CardioOncology, 4(5). -
Osimertinib-Associated Cardiomyopathy In Patients With Non-Small Cell Lung Cancer: A Case Series
Franquiz, M., Waliany, S., Xu, A., Hnatiuk, A., Wu, S., Cheng, P., … Zhu, H. (2023). Osimertinib-Associated Cardiomyopathy In Patients With Non-Small Cell Lung Cancer: A Case Series. JACC: CardioOncology, 839–841. -
Immunotherapy-Associated Atherosclerosis: A Comprehensive Review of Recent Findings and Implications for Future Research
Chan, A., Torelli, S., Cheng, E., Batchelder, R., Waliany, S., Neal, J., … Zhu, H. (2023). Immunotherapy-Associated Atherosclerosis: A Comprehensive Review of Recent Findings and Implications for Future Research. Current Treatment Options in Cardiovascular Medicine.
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Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Study of Daratumumab for Decreasing Circulating Antibodies in Sensitized Patients Awaiting Heart Transplantation
- Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy
- Open-Label Study of AG10 in Patients With Cardiomyopathy
- Daratumumab-SC for Highly Sensitized Patients Awaiting Heart Transplantation
Practice Locations
Amyloid Center Stanford, CA
Stanford, CAAmyloid Center
300 Pasteur Dr, 2nd Fl Rm A260
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereHeart Transplant Program Stanford, CA
Stanford, CAHeart Transplant Program
300 Pasteur Dr, 2nd Fl Rm A21
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereHeart Failure Clinic at Stanford Stanford, CA
Stanford, CAHeart Failure Clinic at Stanford
300 Pasteur Dr, 2nd Fl Rm A260
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
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