

Biography
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Pulmonary Disease (2024)
- Fellowship: Stanford University Pulmonary and Critical Care Fellowship (2006) CA
- Medical Education: UC Irvine School of Medicine (1999) CA
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- Fellowship: Stanford University School of Medicine (2005) CA
- Fellowship: University of Irvine Medical Center (2003) CA
- Residency: University of Irvine Medical Center (2002) CA
- Internship: University of Irvine Medical Center (2000) CA
- Super-Fellowship, Stanford University, Pulmonary Vascular Disease (2006)
- Fellowship, Stanford University, Pulmonary & Critical Care (2005)
- Fellowship, UCI Medical Center, Pulmonary & Critical Care (2003)
- Residency, UCI Medical Center, Internal Medicine (2002)
- MD, University of California, Irvine, Medicine (1999)
- BS, University of California, Irvine, Biological Sciences (1994)
Honors & Awards
- Case Presentation Award, ACCP - Chest 2000 (2000)
- Excellence in Research Award, University of California, Irvine School of Biological Sciences (1995)
- Faculty Teaching Award, Dept of Medicine, Stanford (2007)
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- Fellow of the American College of Chest Physicians, American College of Chest Physicians (2008)
- Fellow of the Year, Univ of Califronia, Irvine Medical Center (2002-2003)
- Howard Huges Summer Fellowship, Harvard School of Medicine (1992 & 1993)
- Ralph Waldo Gerard Award for Outstanding Researcher, University of California, Irvine School of Biological Sciences (1994)
- Resident Research Presentation Award, Univ of Calif, Irvine Medical Center - Dept of Medicine (2001)
- Young Investigator Career Development Award, Entelligence Actelion Young Investigators Program (2006-2007)
Memberships
- Scientific Advisory Board, PHaware (2016 - Present)
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Administrative Appointments
- Clinical Director, VMWC Pulmonary Hypertension Database, Vera Moulton Wall Center for Pulmonary Vascular Disease (2006 - Present)
- Director, Adult Pulmonary Hypertension Service, Vera Moulton Wall Center for Pulmonary Vascular Disease (2007 - Present)
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Publications
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CT angiography of pulmonary artery aneurysms in Hughes-Stovin syndrome
Ketchum, E. S., Zamanian, R. T., & Fleischmann, D. (2005). CT angiography of pulmonary artery aneurysms in Hughes-Stovin syndrome. AMERICAN JOURNAL OF ROENTGENOLOGY, 185(2), 330–32. -
Surgical and interventional therapies for pulmonary arterial hypertension
Olsson, J. K., Zamanian, R. T., Feinstein, J. A., & Doyle, R. L. (2005). Surgical and interventional therapies for pulmonary arterial hypertension. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 26(4), 417–28. -
Management strategies for patients with pulmonary hypertension in the intensive care unit
Zamanian, R. T., Haddad, F., Doyle, R. L., & Weinacker, A. B. (2007). Management strategies for patients with pulmonary hypertension in the intensive care unit. CRITICAL CARE MEDICINE, 35(9), 2037–50. -
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Surrogate and combined end points in pulmonary arterial hypertension.
Ventetuolo, C. E., Benza, R. L., Peacock, A. J., Zamanian, R. T., Badesch, D. B., & Kawut, S. M. (2008). Surrogate and combined end points in pulmonary arterial hypertension. Proceedings of the American Thoracic Society, 5(5), 617–622. -
Effectiveness and cost effectiveness of thrombolysis in patients with acute pulmonary embolism
Zamanian, R. T., & Gould, M. K. (2008). Effectiveness and cost effectiveness of thrombolysis in patients with acute pulmonary embolism. CURRENT OPINION IN PULMONARY MEDICINE, 14(5), 422–26. -
Progressive dyspnea after CABG: Complication of retained epicardial pacing wires
Horng, G. S., Ashley, E., Balsam, L., Reitz, B., & Zamanian, R. T. (2008). Progressive dyspnea after CABG: Complication of retained epicardial pacing wires. ANNALS OF THORACIC SURGERY, 86(4), 1352–54. -
ERG evaluation of daily, high-dose sildenafil usage
Zoumalan, C. I., Zamanian, R. T., Doyle, R. L., & Marmor, M. F. (2009). ERG evaluation of daily, high-dose sildenafil usage. DOCUMENTA OPHTHALMOLOGICA, 118(3), 225–31. -
Insulin resistance in pulmonary arterial hypertension
Zamanian, R. T., Hansmann, G., Snook, S., Lilienfeld, D., Rappaport, K. M., Reaven, G. M., … Doyle, R. L. (2009). Insulin resistance in pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL, 33(2), 318–24. -
Angina Associated With Left Main Coronary Artery Compression in Pulmonary Hypertension
Perez, V. A. J., Haddad, F., Vagelos, R. H., Fearon, W., Feinstein, J., & Zamanian, R. T. (2009). Angina Associated With Left Main Coronary Artery Compression in Pulmonary Hypertension. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 28(5), 527–30. -
PPAR gamma Activation: A Potential Treatment for Pulmonary Hypertension
Hansmann, G., & Zamanian, R. T. (2009). PPAR gamma Activation: A Potential Treatment for Pulmonary Hypertension. SCIENCE TRANSLATIONAL MEDICINE, 1(12). -
Characterization of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension From REVEAL Identifying Systemic Sclerosis as a Unique Phenotype
Chung, L., Liu, J., Parsons, L., Hassoun, P. M., McGoon, M., Badesch, D. B., … Zamanian, R. T. (2010). Characterization of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension From REVEAL Identifying Systemic Sclerosis as a Unique Phenotype. CHEST, 138(6), 1383–94. -
Worldwide Physician Education and Training in Pulmonary Hypertension Pulmonary Vascular Disease: The Global Perspective
Elliott, C. G., Barst, R. J., Seeger, W., Porres-Aguilar, M., Brown, L. M., Zamanian, R. T., & Rubin, L. J. (2010). Worldwide Physician Education and Training in Pulmonary Hypertension Pulmonary Vascular Disease: The Global Perspective. CHEST, 137(6), 85S–94S. -
Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.
Kudelko, K. T., Nadeau, K., Leung, A. N., Liu, J., Haddad, F., Zamanian, R. T., & de Jesus Perez, V. (2010). Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay. Journal of Heart and Lung Transplantation , 29(9), 1071–75. -
Right ventricular failure: a novel era of targeted therapy.
Banerjee, D., Haddad, F., Zamanian, R. T., & Nagendran, J. (2010). Right ventricular failure: a novel era of targeted therapy. Current Heart Failure Reports, 7(4), 202–11. -
Colonic ulceration as an unusual manifestation of vasculopathy in systemic sclerosis
Kao, L., Myer, P., Nguyen, L., Zamanian, R. T., & Chung, L. (2011). Colonic ulceration as an unusual manifestation of vasculopathy in systemic sclerosis. RHEUMATOLOGY, 50(3), 626–28. -
Drugs and toxins-associated pulmonary arterial hypertension: lessons learned and challenges ahead.
de Jesus Perez, V., Kudelko, K., Snook, S., & Zamanian, R. T. (2011). Drugs and toxins-associated pulmonary arterial hypertension: lessons learned and challenges ahead. International Journal of Clinical Practice. Supplement, (169), 8–10. -
Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension
Chandra, S. M., Razavi, H., Kim, J. M., Agrawal, R., Kundu, R. K., Perez, V. D. J., … Chun, H. J. (2011). Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(4), 814–U212. -
Chronic Thromboembolic Pulmonary Hypertension
Perez, V. A. J., & Zamanian, R. T. (2011). Chronic Thromboembolic Pulmonary Hypertension. NEW ENGLAND JOURNAL OF MEDICINE, 364(17), 1677–77. -
Incidence, Correlates, and Consequences of Acute Kidney Injury in Patients With Pulmonary Arterial Hypertension Hospitalized With Acute Right-Side Heart Failure
Haddad, F., Fuh, E., Peterson, T., Skhiri, M., Kudelko, K. T., Perez, V. D. J., … Zamanian, R. T. (2011). Incidence, Correlates, and Consequences of Acute Kidney Injury in Patients With Pulmonary Arterial Hypertension Hospitalized With Acute Right-Side Heart Failure. JOURNAL OF CARDIAC FAILURE, 17(7), 533–39. -
Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension
Hansmann, G., Plouffe, B. D., Hatch, A., von Gise, A., Sallmon, H., Zamanian, R. T., & Murthy, S. K. (2011). Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension. JOURNAL OF MOLECULAR MEDICINE-JMM, 89(10), 971–83. -
Pulmonary Hypertension Associated With Left Heart Disease: Characteristics, Emerging Concepts, and Treatment Strategies
Haddad, F., Kudelko, K., Mercier, O., Vrtovec, B., Zamanian, R. T., & Perez, V. D. J. (2011). Pulmonary Hypertension Associated With Left Heart Disease: Characteristics, Emerging Concepts, and Treatment Strategies. PROGRESS IN CARDIOVASCULAR DISEASES, 54(2), 154–67. -
Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension
Haddad, F., Peterson, T., Fuh, E., Kudelko, K. T., Perez, V. D. J., Skhiri, M., … Zamanian, R. T. (2011). Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension. CIRCULATION-HEART FAILURE, 4(6), 692–99. -
Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction.
Perez, V. A. J., Haddad, F., & Zamanian, R. T. (2012). Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction. Pulmonary Circulation, 2(2), 163–69. -
Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension.
de Jesus Perez, V. A., Rosenzweig, E., Rubin, L. J., Poch, D., Bajwa, A., Park, M., … Zamanian, R. T. (2012). Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension. American Journal of Cardiology, 110(10), 1546–50. -
Airway Management and Perioperative Decision Making in the Patient With Severe Pulmonary Hypertension Who Requires Emergency Noncardiac Surgery
Maxwell, B. G., Pearl, R. G., Kudelko, K. T., Zamanian, R. T., & Hill, C. C. (2012). Airway Management and Perioperative Decision Making in the Patient With Severe Pulmonary Hypertension Who Requires Emergency Noncardiac Surgery. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 26(5), 940–44. -
Pulmonary Arterial Hypertension: New Insights Into the Optimal Role of Current and Emerging Prostacyclin Therapies
Waxman, A. B., & Zamanian, R. T. (2013). Pulmonary Arterial Hypertension: New Insights Into the Optimal Role of Current and Emerging Prostacyclin Therapies. AMERICAN JOURNAL OF CARDIOLOGY, 111(5), 1A–16A. -
Functional Class Improvement and 3-Year Survival Outcomes in Patients With Pulmonary Arterial Hypertension in the REVEAL Registry
Barst, R. J., Chung, L., Zamanian, R. T., Turner, M., & Mcgoon, M. D. (2013). Functional Class Improvement and 3-Year Survival Outcomes in Patients With Pulmonary Arterial Hypertension in the REVEAL Registry. CHEST, 144(1), 160–68. -
Transplantation for Idiopathic Pulmonary Arterial Hypertension Improvement in the Lung Allocation Score Era
Schaffer, J. M., Singh, S. K., Joyce, D. L., Reitz, B. A., Robbins, R. C., Zamanian, R. T., & Mallidi, H. R. (2013). Transplantation for Idiopathic Pulmonary Arterial Hypertension Improvement in the Lung Allocation Score Era. CIRCULATION, 127(25), 2503–13. -
Regulative response of the cranial neural tube after neural fold ablation: Spatiotemporal nature of neural crest regeneration and up-regulation of Slug
Sechrist, J., Nieto, M. A., Zamanian, R. T., & BRONNERFRASER, M. (1995). Regulative response of the cranial neural tube after neural fold ablation: Spatiotemporal nature of neural crest regeneration and up-regulation of Slug. DEVELOPMENT, 121(12), 4103–4115. -
Survival in Pulmonary Hypertension Registries The Importance of Incident Cases Response
Chung, L., Liu, J., Parsons, L. S., Hassoun, P. M., McGoon, M. D., Badesch, D. B., … Zamanian, R. T. (2011). Survival in Pulmonary Hypertension Registries The Importance of Incident Cases Response. CHEST, 139(6), 1548–49. -
Chloride intracellular channel 4 (CLIC4), a novel downstream target of bone morphogenetic protein receptor II (BMPR-II) in human pulmonary artery smooth muscle cell (PASMC) migration
Spiekerkoetter, E., Wang, L. L., Zamanian, R., Ambartsumian, N., Schmidt, A. M., Lukanidin, E., & RABINOVITCH, M. (2005). Chloride intracellular channel 4 (CLIC4), a novel downstream target of bone morphogenetic protein receptor II (BMPR-II) in human pulmonary artery smooth muscle cell (PASMC) migration. CIRCULATION. DALLAS,TX,TX,TX,TX: LIPPINCOTT WILLIAMS & WILKINS. -
IMPROVEMENT IN RIGHT ATRIAL FUNCTION IS ASSOCIATED WITH IMPROVED FUNCTIONAL CAPACITY IN PULMONARY ARTERIAL HYPERTENSION
Brunner, N. W., Haddad, F., Swiston, J. R., Gin, K., Tsang, T. S. M., & Zamanian, R. T. (2013). IMPROVEMENT IN RIGHT ATRIAL FUNCTION IS ASSOCIATED WITH IMPROVED FUNCTIONAL CAPACITY IN PULMONARY ARTERIAL HYPERTENSION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E1246–E1246. -
RIGHT ATRIAL EMPTYING FRACTIONS ARE ASSOCIATED WITH SURVIVAL IN PULMONARY ARTERIAL HYPERTENSION
Brunner, N. W., Haddad, F., Swiston, J. R., Gin, K., Tsang, T. S. M., & Zamanian, R. T. (2013). RIGHT ATRIAL EMPTYING FRACTIONS ARE ASSOCIATED WITH SURVIVAL IN PULMONARY ARTERIAL HYPERTENSION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E896–E896. -
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Tian, W., Jiang, X., Tamosiuniene, R., Sung, Y. K., Qian, J., Dhillon, G., … Nicolls, M. R. (2013). Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Science Translational Medicine, 5(200), 200ra117-? -
Blocking Macrophage Leukotriene B-4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension
Tian, W., Jiang, X., Tamosiuniene, R., Sung, Y. K., Qian, J., Dhillon, G., … Nicolls, M. R. (2013). Blocking Macrophage Leukotriene B-4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension. SCIENCE TRANSLATIONAL MEDICINE, 5(200). -
A case of recurrent pericardial constriction presenting with severe pulmonary hypertension.
Brunner, N. W., Ramachandran, K., Kudelko, K. T., Sung, Y. K., Spiekerkoetter, E., Yang, P. C., … Perez, V. deJ. (2013). A case of recurrent pericardial constriction presenting with severe pulmonary hypertension. Pulmonary Circulation, 3(2), 436–39. -
Septal curvature is marker of hemodynamic, anatomical, and electromechanical ventricular interdependence in patients with pulmonary arterial hypertension.
Haddad, F., Guihaire, J., Skhiri, M., Denault, A. Y., Mercier, O., Al-Halabi, S., … Schnittger, I. (2014). Septal curvature is marker of hemodynamic, anatomical, and electromechanical ventricular interdependence in patients with pulmonary arterial hypertension. Echocardiography (Mount Kisco, N.Y.), 31(6), 699–707. -
Relationship between Echocardiographic and Magnetic Resonance Derived Measures of Right Ventricular Size and Function in Patients with Pulmonary Hypertension.
Shiran, H., Zamanian, R. T., McConnell, M. V., Liang, D. H., Dash, R., Heidary, S., … Yang, P. C. (2014). Relationship between Echocardiographic and Magnetic Resonance Derived Measures of Right Ventricular Size and Function in Patients with Pulmonary Hypertension. Journal of the American Society of Echocardiography , 27(4), 405–12. -
Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension
Perez, V. A. J., Yuan, K., Lyuksyutova, M. A., Dewey, F., Orcholski, M. E., Shuffle, E. M., … Zamanian, R. T. (2014). Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189(10), 1260–72. -
Response to letter regarding article, "transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era".
Schaffer, J. M., Singh, S. K., Joyce, D. L., Reitz, B. A., Robbins, R. C., Zamanian, R. T., & Mallidi, H. R. (2014). Response to letter regarding article, "transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era". Circulation, 129(16). -
Current Clinical Management of Pulmonary Arterial Hypertension
Zamanian, R. T., Kudelko, K. T., Sung, Y. K., Perez, V. D. J., Liu, J., & Spiekerkoetter, E. (2014). Current Clinical Management of Pulmonary Arterial Hypertension. CIRCULATION RESEARCH, 115(1), 131–47. -
Impact of insulin resistance on ventricular function in pulmonary arterial hypertension.
Brunner, N. W., Skhiri, M., Fortenko, O., Hsi, A., Haddad, F., Khazeni, N., & Zamanian, R. T. (2014). Impact of insulin resistance on ventricular function in pulmonary arterial hypertension. Journal of Heart and Lung Transplantation , 33(7), 721–26. -
Erythropoietin upregulation in pulmonary arterial hypertension.
Karamanian, V. A., Harhay, M., Grant, G. R., Palevsky, H. I., Grizzle, W. E., Zamanian, R. T., … Jones, P. L. (2014). Erythropoietin upregulation in pulmonary arterial hypertension. Pulmonary Circulation, 4(2), 269–79. -
Unique predictors of mortality in patients with pulmonary arterial hypertension associated with systemic sclerosis in the REVEAL registry.
Chung, L., Farber, H. W., Benza, R., Miller, D. P., Parsons, L., Hassoun, P. M., … Zamanian, R. T. (2014). Unique predictors of mortality in patients with pulmonary arterial hypertension associated with systemic sclerosis in the REVEAL registry. Chest, 146(6), 1494–1504. -
A preliminary study investigating the quantification of beat-to-beat in seismocardiogram signals.
Inan, O. T., Pandia, K., Giovangrandi, L., Zamanian, R. T., & Kovacs, G. T. A. (2013). A preliminary study investigating the quantification of beat-to-beat in seismocardiogram signals. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2013, 7286–89. -
Single- vs double-lung transplantation in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis since the implementation of lung allocation based on medical need.
Schaffer, J. M., Singh, S. K., Reitz, B. A., Zamanian, R. T., & Mallidi, H. R. (2015). Single- vs double-lung transplantation in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis since the implementation of lung allocation based on medical need. JAMA, 313(9), 936–48. -
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
Nickel, N. P., Spiekerkoetter, E., Gu, M., Li, C. G., Li, H., Kaschwich, M., … Rabinovitch, M. (2015). Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(11), 1273–86. -
Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension.
Haddad, F., Spruijt, O. A., Denault, A. Y., Mercier, O., Brunner, N., Furman, D., … Zamanian, R. T. (2015). Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension. JACC. Cardiovascular Imaging, 8(6), 627–38. -
RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension
Rhodes, C. J., Im, H., Cao, A., Hennigs, J. K., Wang, L., Sa, S., … Rabinovitch, M. (2015). RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 192(3), 356–66. -
Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus).
Brunner, N. W., Zamanian, R. T., Ikeno, F., Mitsutake, Y., Connolly, A. J., Shuffle, E., … de Jesus Perez, V. A. (2015). Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus). Comparative Medicine, 65(3), 217–24. -
Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
Spiekerkoetter, E., Sung, Y. K., Sudheendra, D., Bill, M., Aldred, M. A., van de Veerdonk, M. C., … Zamanian, R. T. (2015). Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 192(2), 254–57. -
Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension
Haddad, F., Spruijt, O. A., Denault, A. Y., Mercier, O., Brunner, N., Furman, D., … Zamanian, R. T. (2015). Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension. JACC-CARDIOVASCULAR IMAGING, 8(6), 627–38. -
Prognostic utility of right atrial emptying fractions in pulmonary arterial hypertension.
Brunner, N. W., Haddad, F., Kobayashi, Y., Hsi, A., Swiston, J. R., Gin, K. G., & Zamanian, R. T. (2015). Prognostic utility of right atrial emptying fractions in pulmonary arterial hypertension. Pulmonary Circulation, 5(3), 473–80. -
Leukotriene B-4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension
Qian, J., Tian, W., Jiang, X., Tamosiuniene, R., Sung, Y. K., Shuffle, E. M., … Nicolls, M. R. (2015). Leukotriene B-4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. HYPERTENSION, 66(6), 1227–39. -
Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography.
Amsallem, M., Sternbach, J. M., Adigopula, S., Kobayashi, Y., Vu, T. A., Zamanian, R., … Haddad, F. (2015). Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. -
Ambrisentan and Tadalafil Up-front Combination Therapy in Scleroderma-associated Pulmonary Arterial Hypertension
Hassoun, P. M., Zamanian, R. T., Damico, R., Lechtzin, N., Khair, R., Kolb, T. M., … Mathai, S. C. (2015). Ambrisentan and Tadalafil Up-front Combination Therapy in Scleroderma-associated Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 192(9), 1102–10. -
Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography
Amsallem, M., Sternbach, J. M., Adigopula, S., Kobayashi, Y., Vu, T. A., Zamanian, R., … Haddad, F. (2016). Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 29(2), 93–102. -
Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program
Maron, B. A., Hess, E., Maddox, T. M., Opotowsky, A. R., Tedford, R. J., Lahm, T., … Choudhary, G. (2016). Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. CIRCULATION, 133(13), 1240–48. -
An observational study of inhaled-treprostinil respiratory-related safety in patients with pulmonary arterial hypertension.
Zamanian, R. T., Levine, D. J., Bourge, R. C., De Souza, S. A., Rosenzweig, E. B., Alnuaimat, H., … De Marco, T. (2016). An observational study of inhaled-treprostinil respiratory-related safety in patients with pulmonary arterial hypertension. Pulmonary Circulation, 6(3), 329–37. -
Epoprostenol-associated pneumonitis: Diagnostic use of a T-cell proliferation assay
Kudelko, K. T., Nadeau, K., Leung, A. N., Liu, J., Haddad, F., Zamanian, R. T., & Perez, V. D. J. (2010). Epoprostenol-associated pneumonitis: Diagnostic use of a T-cell proliferation assay. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(9), 1071–75. -
Safety and Efficacy of Transition from Systemic Prostanoids to Inhaled Treprostinil in Pulmonary Arterial Hypertension
Perez, V. A. J., Rosenzweig, E., Rubin, L. J., Poch, D., Bajwa, A., Park, M., … Zamanian, R. T. (2012). Safety and Efficacy of Transition from Systemic Prostanoids to Inhaled Treprostinil in Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF CARDIOLOGY, 110(10), 1546–50. -
Left Atrium Maximal Axial Cross-Sectional Area is a Specific Computed Tomographic Imaging Biomarker of World Health Organization Group 2 Pulmonary Hypertension.
Jivraj, K., Bedayat, A., Sung, Y. K., Zamanian, R. T., Haddad, F., Leung, A. N. C., … Guo, H. H. (2017). Left Atrium Maximal Axial Cross-Sectional Area is a Specific Computed Tomographic Imaging Biomarker of World Health Organization Group 2 Pulmonary Hypertension. Journal of Thoracic Imaging, 32(2), 121–26. -
Investigating the value of right heart echocardiographic metrics for detection of pulmonary hypertension in patients with advanced lung disease.
Amsallem, M., Boulate, D., Kooreman, Z., Zamanian, R. T., Fadel, G., Schnittger, I., … Haddad, F. (2017). Investigating the value of right heart echocardiographic metrics for detection of pulmonary hypertension in patients with advanced lung disease. The International Journal of Cardiovascular Imaging. -
Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry.
Chung, L., Fairchild, R. M., Furst, D. E., Li, S., Alkassab, F., Bolster, M. B., … Zamanian, R. T. (2016). Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry. Clinical and Experimental Rheumatology, -? -
antagonism ameliorates experimental lymphedema.
Tian, W., Rockson, S. G., Jiang, X., Kim, J., Begaye, A., Shuffle, E. M., … Nicolls, M. R. (2017). antagonism ameliorates experimental lymphedema. Science Translational Medicine, 9(389). -
Identification of Pulmonary Hypertension Caused by Left Heart Disease (World Health Organization Group 2) Based on Cardiac Chamber Volumes Derived from Chest CT.
Aviram, G., Rozenbaum, Z., Ziv-Baran, T., Berliner, S., Topilsky, Y., Fleischmann, D., … Guo, H. H. (2017). Identification of Pulmonary Hypertension Caused by Left Heart Disease (World Health Organization Group 2) Based on Cardiac Chamber Volumes Derived from Chest CT. Chest. -
Leukotriene B-4 antagonism ameliorates experimental lymphedema
Tian, W., Rockson, S. G., Jiang, X., Kim, J., Begaye, A., Shuffle, E. M., … Nicolls, M. R. (2017). Leukotriene B-4 antagonism ameliorates experimental lymphedema. SCIENCE TRANSLATIONAL MEDICINE, 9(389). -
A case of recurrent pericardial constriction presenting with severe pulmonary hypertension
Brunner, N. W., Ramachandran, K., Kudelko, K. T., Sung, Y. K., Spiekerkoetter, E., Yang, P. C., … Perez, V. de J. (2013). A case of recurrent pericardial constriction presenting with severe pulmonary hypertension. PULMONARY CIRCULATION, 3(2), 436–39. -
Erythropoietin upregulation in pulmonary arterial hypertension
Karamanian, V. A., Harhay, M., Grant, G. R., Palevsky, H. I., Grizzle, W. E., Zamanian, R. T., … Jones, P. L. (2014). Erythropoietin upregulation in pulmonary arterial hypertension. PULMONARY CIRCULATION, 4(2), 269–79. -
Kidney dysfunction in patients with pulmonary arterial hypertension
Nickel, N. P., O'Leary, J. M., Brittain, E. L., Fessel, J. P., Zamanian, R. T., West, J. D., & Austin, E. D. (2017). Kidney dysfunction in patients with pulmonary arterial hypertension. PULMONARY CIRCULATION, 7(1), 38–54. -
REDUCED CARBOXYLESTERASE 1 IS ASSOCIATED WITH ENDOTHELIAL INJURY IN METHAMPHETAMINE INDUCED PULMONARY ARTERIAL HYPERTENSION.
Orcholski, M. E., Khurshudyan, A., Shamskhou, E. A., Yuan, K., Chen, I. Y., Kodani, S. D., … de Jesus Perez, V. A. (2017). REDUCED CARBOXYLESTERASE 1 IS ASSOCIATED WITH ENDOTHELIAL INJURY IN METHAMPHETAMINE INDUCED PULMONARY ARTERIAL HYPERTENSION. American Journal of Physiology. Lung Cellular and Molecular Physiology, ajplung 00453 2016-? -
Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models.
Amsallem, M., Sweatt, A. J., Aymami, M. C., Kuznetsova, T., Selej, M., Lu, H. Q., … Haddad, F. (2017). Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models. Circulation. Cardiovascular Imaging, 10(6). -
What's in a side effect? The association between pulmonary vasodilator adverse drug events and clinical outcomes in patients with pulmonary arterial hypertension.
Leary, P. J., Kang, S., Kolb, T. M., Maron, B. A., Ralph, D. D., Rao, Y., … Zamanian, R. T. (2017). What's in a side effect? The association between pulmonary vasodilator adverse drug events and clinical outcomes in patients with pulmonary arterial hypertension. International Journal of Cardiology. -
Features and Outcomes of Methamphetamine Associated Pulmonary Arterial Hypertension.
Zamanian, R. T., Hedlin, H., Greuenwald, P., Wilson, D. M., Segal, J. I., Jorden, M., … Kawut, S. M. (2017). Features and Outcomes of Methamphetamine Associated Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.
Saito, T., Miyagawa, K., Chen, S.-Y. Y., Tamosiuniene, R., Wang, L., Sharp, O., … Rabinovitch, M. (2017). Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension. Circulation. -
Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension.
Malhotra, R., Paskin-Flerlage, S., Zamanian, R. T., Zimmerman, P., Schmidt, J. W., Deng, D. Y., … Yu, P. B. (2013). Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. Pulmonary Circulation, 3(2), 369–80. -
Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension
Malhotra, R., Paskin-Flerlage, S., Zamanian, R. T., Zimmerman, P., Schmidt, J. W., Deng, D. Y., … Yu, P. B. (2013). Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. PULMONARY CIRCULATION, 3(2), 369–80. -
Load Adaptability in Patients With Pulmonary Arterial Hypertension.
Amsallem, M. (2017). Load Adaptability in Patients With Pulmonary Arterial Hypertension. Am J Cardiol, 874–82. -
Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension.
Blum, L. K., Cao, R. R., Sweatt, A. J., Bill, M., Lahey, L. J., Hsi, A. C., … Robinson, W. H. (2018). Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension. European Journal of Immunology. -
DRUG INDUCED PULMONARY ARTERIAL HYPERTENSION: A PRIMER FOR CLINICIANS AND SCIENTISTS.
Orcholski, M. E., Yuan, K., Rajasingh, C., Tsai, H., Shamskhou, E. A., Dhillon, N. K., … de Jesus Perez, V. A. (2018). DRUG INDUCED PULMONARY ARTERIAL HYPERTENSION: A PRIMER FOR CLINICIANS AND SCIENTISTS. American Journal of Physiology. Lung Cellular and Molecular Physiology. -
Critical assessment of right heart echocardiography for detection of pulmonary hypertension in advanced lung disease
Amsallem, M., Boulate, D., Kooreman, Z. E., Zamanian, R., Fadel, G., Schnittger, I., … Haddad, F. (2016). Critical assessment of right heart echocardiography for detection of pulmonary hypertension in advanced lung disease. EUROPEAN HEART JOURNAL. OXFORD UNIV PRESS. -
Identification of Biomarkers Predictive of Pulmonary Arterial Hypertension in Systemic Sclerosis
Kolstad, K. D., Holmes, T., Rosenberg-Hasson, Y., Sweatt, A., Zamanian, R. T., Li, S., … Chung, L. (2017). Identification of Biomarkers Predictive of Pulmonary Arterial Hypertension in Systemic Sclerosis. ARTHRITIS & RHEUMATOLOGY, 69. -
Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension
Spiekerkoetter, E., Sung, Y. K., Sudheendra, D., Scott, V., Del Rosario, P., Bill, M., … Zamanian, R. T. (2017). Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL, 50(3). -
The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study
Sato, T., Ambale-Venkatesh, B., Lima, J. A. C., Zimmerman, S. L., Tedford, R. J., Fujii, T., … Hassoun, P. M. (2018). The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study. PULMONARY CIRCULATION, 8(1), 2045893217748307. -
Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension
Mercurio, V., Mukherjee, M., Tedford, R. J., Zamanian, R. T., Khair, R. M., Sato, T., … Hassoun, P. M. (2018). Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197(3), 388–91. -
Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients
Duarte, J. D., Kansal, M., Desai, A. A., Riden, K., Arwood, M. J., Yacob, A. A., … Machado, R. F. (2018). Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients. PULMONARY CIRCULATION, 8(2), 2045894018773049. -
Reply: Can treprostinil-induced early gastrointestinal side effects serve as predictors of pulmonary arterial hypertension prognosis?
Leary, P. J., Kolb, T. M., Maron, B. A., Tedford, R. J., & Zamanian, R. T. (2018). Reply: Can treprostinil-induced early gastrointestinal side effects serve as predictors of pulmonary arterial hypertension prognosis? INTERNATIONAL JOURNAL OF CARDIOLOGY, 264, 188. -
Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry
Chung, L., Fairchild, R. M., Furst, D. E., Li, S., Alkassab, F., Bolster, M. B., … Zamanian, R. T. (2017). Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 35(4), S106–S113. -
Sex-based differences in veterans with pulmonary hypertension: Results from the veterans affairs-clinical assessment reporting and tracking database
Ventetuolo, C. E., Hess, E., Austin, E. D., Baron, A. E., Klinger, J. R., Lahm, T., … Maron, B. A. (2017). Sex-based differences in veterans with pulmonary hypertension: Results from the veterans affairs-clinical assessment reporting and tracking database. PLOS ONE, 12(11), e0187734. -
Rapidly Rising Burden of Portopulmonary Hypertension in the United States
Rahim, U., Mannalithara, A., Kim, D., Zamanian, R., & Kim, W. R. (2017). Rapidly Rising Burden of Portopulmonary Hypertension in the United States. HEPATOLOGY, 66, 253A–254A. -
EXPRESS: Non-invasive Right Ventricular Load Adaptability Indices in Patients with Scleroderma-Associated Pulmonary Arterial Hypertension.
French, S., Amsallem, M., Ouazani, N., Li, S., Kudelko, K., Zamanian, R., … Chung, L. (2018). EXPRESS: Non-invasive Right Ventricular Load Adaptability Indices in Patients with Scleroderma-Associated Pulmonary Arterial Hypertension. Pulmonary Circulation, 2045894018788268. -
H2 Receptor Antagonist Use and Mortality in Pulmonary Hypertension: Insight from the VA-CART Program
Leary, P. J., Hess, E., Baron, A. E., Branch, K. R., Choudhary, G., Hough, C. L., … Lahm, T. (2018). H2 Receptor Antagonist Use and Mortality in Pulmonary Hypertension: Insight from the VA-CART Program. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197(12), 1638–41. -
Differential expression of hepatocyte growth factor in patients with systemic sclerosis-associated pulmonary arterial hypertension
Sung, Y. K., Zamanian, R. T., Wagner, C. A., Robinson, W., Steen, V., & Chung, L. (2017). Differential expression of hepatocyte growth factor in patients with systemic sclerosis-associated pulmonary arterial hypertension. JOURNAL OF SCLERODERMA AND RELATED DISORDERS, 2(3), 225–30. -
Methamphetamine and the risk of pulmonary arterial hypertension.
Ramirez, R. L., Perez, V. D., & Zamanian, R. T. (2018). Methamphetamine and the risk of pulmonary arterial hypertension. Current Opinion in Pulmonary Medicine. -
Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report
Elinoff, J. M., Agarwal, R., Barnett, C. F., Benza, R. L., Cuttica, M. J., Gharib, A. M., … Solomon, M. A. (2018). Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 198(2), 166–74. -
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension
Taylor, S., Dirir, O., Zamanian, R. T., Rabinovitch, M., & Thompson, A. A. R. (2018). The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension. FRONTIERS IN MEDICINE, 5. -
Prevention of Deep Vein Thrombosis and Pulmonary Embolism in High-Risk Medical Patients
McCullough, M., Kholdani, C., & Zamanian, R. T. (2018). Prevention of Deep Vein Thrombosis and Pulmonary Embolism in High-Risk Medical Patients. CLINICS IN CHEST MEDICINE, 39(3), 483-+. -
Psychometric Validation of the Pulmonary Arterial Hypertension- Symptoms and Impact (PAH-SYMPACT) Questionnaire Results of the SYMPHONY Trial
Chin, K. M., Gomberg-Maitland, M., Channick, R. N., Cuttica, M. J., Fischer, A., Frantz, R. P., … Badesch, D. B. (2018). Psychometric Validation of the Pulmonary Arterial Hypertension- Symptoms and Impact (PAH-SYMPACT) Questionnaire Results of the SYMPHONY Trial. CHEST, 154(4), 848–61. -
Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension
Abbasi, Y., Jabbari, J., Jabbari, R., Glinge, C., Izadyar, S. B., Spiekerkoetter, E., … Tfelt-Hansen, J. (2018). Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension. MOLECULAR GENETICS & GENOMIC MEDICINE, 6(5), 835–44. -
Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension.
Nikolic, I., Yung, L.-M., Yang, P., Malhotra, R., Paskin-Flerlage, S. D., Dinter, T., … Yu, P. B. (2018). Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Clinical Heterogeneity Across Proteomic Immunophenotypes In Pulmonary Arterial Hypertension
Sweatt, A., Hedlin, H., Balasubramanian, V., Hsi, A., Blum, L., Robinson, W., … Zamanian, R. T. (2017). Clinical Heterogeneity Across Proteomic Immunophenotypes In Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Hospital Readmission Rate and Associated Survival for Patients with Pulmonary Arterial Hypertension at a Tertiary Academic Medical Center
Kholdani, C., Lee, J., Hedlin, H., Hsi, A., Sweatt, A., Kudelko, K., … Zamanian, R. T. (2018). Hospital Readmission Rate and Associated Survival for Patients with Pulmonary Arterial Hypertension at a Tertiary Academic Medical Center. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197. -
Low-Grade Albuminuria in Linked to Inflammation and Is Associated with Poor Outcome in Pulmonary Arterial Hypertension
Nickel, N., Austin, E. D., Perez, V. D. J., Zamanian, R. T., West, J. D., de Caestecker, M., & Yang, H. (2018). Low-Grade Albuminuria in Linked to Inflammation and Is Associated with Poor Outcome in Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197. -
Bone Morphogenetic Protein Receptor 2 Expression Is Reduced in Blood Across Pulmonary Arterial Hypertension Subtypes but Does Not Reflect Disease Severity
Sweatt, A., Wells, R. E., Purington, N., Hedlin, H., Sudheendra, D., Hsi, A., … Spiekerkoetter, E. F. (2018). Bone Morphogenetic Protein Receptor 2 Expression Is Reduced in Blood Across Pulmonary Arterial Hypertension Subtypes but Does Not Reflect Disease Severity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197. -
Frequency of Palliative Care Referrals in Newly Diagnosed Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry
Gray, M. P., Wright, R., Khair, R. M., Badesch, D. B., Bartolome, S., Boyle, K., … Mathai, S. C. (2018). Frequency of Palliative Care Referrals in Newly Diagnosed Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197. -
The Minimal Important Difference of the Tricuspid Annular Plane Systolic Excursion in Scleroderma-Associated Pulmonary Arterial Hypertension
Khair, R., Mukherjee, M., Kolb, T. M., Damico, R. L., Hassoun, P. M., Zamanian, R. T., … Mathai, S. C. (2018). The Minimal Important Difference of the Tricuspid Annular Plane Systolic Excursion in Scleroderma-Associated Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197. -
Clinical trial design and new therapies for pulmonary arterial hypertension.
Sitbon, O., Gomberg-Maitland, M., Granton, J., Lewis, M. I., Mathai, S. C., Rainisio, M., … Rubin, L. J. (2018). Clinical trial design and new therapies for pulmonary arterial hypertension. The European Respiratory Journal. -
Outcomes of women with primary and secondary pulmonary hypertension during pregnancy
Blumenfeld, Y. J., Girsen, A. I., Druzin, M. L., Lyell, D. J., Bianco, K. Y., Herrero, T., … El-Sayed, Y. Y. (2019). Outcomes of women with primary and secondary pulmonary hypertension during pregnancy. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. MOSBY-ELSEVIER. -
EXPRESS: Low-Grade Albuminuria in Pulmonary Arterial Hypertension.
Nickel, N., Perez, V. inicio A., Fessel, J. P., Cogan, J., Hamid, R., West, J. D., … Austin, E. (2019). EXPRESS: Low-Grade Albuminuria in Pulmonary Arterial Hypertension. Pulmonary Circulation, 2045894018824564. -
Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.
Sweatt, A. J., Hedlin, H. K., Balasubramanian, V., Hsi, A., Blum, L. K., Robinson, W. H., … Zamanian, R. T. (2019). Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension. Circulation Research. -
Management of pulmonary hypertension in the intensive care unit - The author replies
Zamanian, R. T. (2008). Management of pulmonary hypertension in the intensive care unit - The author replies. CRITICAL CARE MEDICINE, 36(2), 652. -
Determinants Of Health Related Quality Of Life In Pah: Data From The Pulmonary Hypertension Association Registry
Zamanian, R. T., Badesch, D., Bull, T. M., DeMarco, T., Feldman, J., Fineman, J., … Sager, J. (2017). Determinants Of Health Related Quality Of Life In Pah: Data From The Pulmonary Hypertension Association Registry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Characterization Of Hispanics With Pulmonary Hypertension In The Us: The Pulmonary Hypertension Association Registry
Perez, V. D. J., Badesch, D., Zamanian, R. T., Fineman, J., Klinger, J. R., Fords, J., … DeMarco, T. (2017). Characterization Of Hispanics With Pulmonary Hypertension In The Us: The Pulmonary Hypertension Association Registry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
CONTENT VALIDATION OF THE PULMONARY ARTERIAL HYPERTENSION SYMPTOMS AND IMPACT (PAH-SYMPACT) QUESTIONNAIRE
Gomberg-Maitland, M., Channick, R., Chin, K., Fischer, A., Frantz, R., Roberts, L., … Badesch, D. (2016). CONTENT VALIDATION OF THE PULMONARY ARTERIAL HYPERTENSION SYMPTOMS AND IMPACT (PAH-SYMPACT) QUESTIONNAIRE. VALUE IN HEALTH. ELSEVIER SCIENCE INC. -
Serial Vasoreactivity Reassessment Is A Prognostic Tool In Pulmonary Arterial Hypertension
Sweatt, A. J., Spiekerkoetter, E. F., Hsi, A., Sung, Y., Perez, V. D. J., Kudelko, K., & Zamanian, R. T. (2016). Serial Vasoreactivity Reassessment Is A Prognostic Tool In Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Demographic, Hemodynamic, and HRQL Differences between Methamphetamine-Associated and Idiopathic PAH: The Pulmonary Hypertension Association Registry
Kolaitis, N. A., Zamanian, R. T., Perez, V. A. de J., Badesch, D. B., Benza, R. L., Burger, C. D., … De Marco, T. (2019). Demographic, Hemodynamic, and HRQL Differences between Methamphetamine-Associated and Idiopathic PAH: The Pulmonary Hypertension Association Registry. JOURNAL OF HEART AND LUNG TRANSPLANTATION. ELSEVIER SCIENCE INC. -
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension.
Taylor, S., Dirir, O., Zamanian, R. T., Rabinovitch, M., & Thompson, A. A. (2018). The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension. Frontiers in Medicine, 5, 217. -
Load Adaptability in Patients With Pulmonary Arterial Hypertension.
Amsallem, M., Boulate, D., Aymami, M., Guihaire, J., Selej, M., Huo, J., … Haddad, F. (2017). Load Adaptability in Patients With Pulmonary Arterial Hypertension. The American Journal of Cardiology, 120(5), 874–882. -
Kidney dysfunction in patients with pulmonary arterial hypertension.
Nickel, N. P., O'Leary, J. M., Brittain, E. L., Fessel, J. P., Zamanian, R. T., West, J. D., & Austin, E. D. (2017). Kidney dysfunction in patients with pulmonary arterial hypertension. Pulmonary Circulation, 7(1), 38–54. -
Current clinical management of pulmonary arterial hypertension.
Zamanian, R. T., Kudelko, K. T., Sung, Y. K., de Jesus Perez, V., Liu, J., & Spiekerkoetter, E. (2014). Current clinical management of pulmonary arterial hypertension. Circulation Research, 115(1), 131–47. -
Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension
Nikolic, I., Yung, L.-M., Yang, P., Malhotra, R., Paskin-Flerlage, S. D., Dinter, T., … Yu, P. B. (2019). Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 199(7), 891–902. -
Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension
Blum, L. K., Cao, R. R. L., Sweatt, A. J., Bill, M., Lahey, L. J., Hsi, A. C., … Robinson, W. H. (2018). Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension. EUROPEAN JOURNAL OF IMMUNOLOGY, 48(5), 874–84. -
Intersecting Identities and Patient Outcomes in Pulmonary Arterial Hypertension: Early Results in Derivation of a Model Using the Pulmonary Hypertension Association Registry (PHAR)
Grinnan, D., Kang, L., DeWilde, C., Johnson, D., Allen, R., Badesch, D. B., … Zamanian, R. T. (2019). Intersecting Identities and Patient Outcomes in Pulmonary Arterial Hypertension: Early Results in Derivation of a Model Using the Pulmonary Hypertension Association Registry (PHAR). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Retinal Vascular Tortuosity, a New Feature of Systemic Manifestation of Pulmonary Arterial Hypertension
Nickel, N. P., Perez, V. D. J., Dubra, A., & Zamanian, R. T. (2019). Retinal Vascular Tortuosity, a New Feature of Systemic Manifestation of Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Nurse Staffing and the Quality of Life and Outcomes of Patients with Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry
Archer-Chicko, C. L., Benza, R. L., Feldman, J. P., Rosenzweig, E. B., Horn, E., Sager, J. S., … Al-Naamani, N. (2019). Nurse Staffing and the Quality of Life and Outcomes of Patients with Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Increasing Age Is Associated with Worsening Physical Function Despite More Favorable Cardiopulmonary Hemodynamics: A Pulmonary Hypertension Association Registry (PHAR) Report
DesJardin, J. T., Kolaitis, N. A., Kime, N., Kronmal, R., Bartolome, S., Badesch, D. B., … De Marco, T. (2019). Increasing Age Is Associated with Worsening Physical Function Despite More Favorable Cardiopulmonary Hemodynamics: A Pulmonary Hypertension Association Registry (PHAR) Report. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Obesity and Quality of Life in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR)
Min, J., Benza, R. L., Feldman, J. P., Rosenzweig, E. B., Horn, E., Sager, J. S., … Al-Naamani, N. (2019). Obesity and Quality of Life in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Non-invasive right ventricular load adaptability indices in patients with scleroderma-associated pulmonary arterial hypertension
French, S., Amsallem, M., Ouazani, N., Li, S., Kudelko, K., Zamanian, R. T., … Chung, L. (2018). Non-invasive right ventricular load adaptability indices in patients with scleroderma-associated pulmonary arterial hypertension. PULMONARY CIRCULATION, 8(3). -
Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension
Sweatt, A. J., Hedlin, H. K., Balasubramanian, V., Hsi, A., Blum, L. K., Robinson, W. H., … Zamanian, R. T. (2019). Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension. CIRCULATION RESEARCH, 124(6), 904–19. -
EXPRESS: Myocardial Bridge - An Unrecognized Cause of Chest Pain in Pulmonary Arterial Hypertension.
Rajmohan, D., Sung, Y. K., Kudelko, K., Perez, V. inicio A., Haddad, F., Tremmel, J., … Spiekerkoetter, E. F. (2019). EXPRESS: Myocardial Bridge - An Unrecognized Cause of Chest Pain in Pulmonary Arterial Hypertension. Pulmonary Circulation, 2045894019860738. -
Low-grade albuminuria in pulmonary arterial hypertension
Nickel, N. P., Perez, V. A. de J., Zamanian, R. T., Fessel, J. P., Cogan, J. D., Hamid, R., … Austin, E. D. (2019). Low-grade albuminuria in pulmonary arterial hypertension. PULMONARY CIRCULATION, 9(2). -
Development and Performance of the Pulmonary Embolism Result Forecast Model (PERFORM) for Computed Tomography Clinical Decision Support.
Banerjee, I., Sofela, M., Yang, J., Chen, J. H., Shah, N. H., Ball, R., … Lungren, M. P. (2019). Development and Performance of the Pulmonary Embolism Result Forecast Model (PERFORM) for Computed Tomography Clinical Decision Support. JAMA Network Open, 2(8), e198719. -
Clinical trial design and new therapies for pulmonary arterial hypertension
Sitbon, O., Gomberg-Maitland, M., Granton, J., Lewis, M. I., Mathai, S. C., Rainisio, M., … Rubin, L. J. (2019). Clinical trial design and new therapies for pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL. EUROPEAN RESPIRATORY SOC JOURNALS LTD. -
Drug-induced pulmonary arterial hypertension: a primer for clinicians and scientists
Orcholski, M. E., Yuan, K., Rajasingh, C., Tsai, H., Shamskhou, E. A., Dhillon, N. K., … Perez, V. A. de J. (2018). Drug-induced pulmonary arterial hypertension: a primer for clinicians and scientists. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 314(6), L967–L983. -
Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011
Tsai, H., Lee, J., Hedlin, H., Zamanian, R., & de Jesus Perez, V. (2019). Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011. European Respiratory Journal Open Research. -
Echocardiographic evaluations of right ventriculo-arterial coupling in experimental and clinical pulmonary hypertension.
Boulate, D., Amsallem, M., Kuznetsova, T., Zamanian, R. T., Fadel, E., Mercier, O., & Haddad, F. (2019). Echocardiographic evaluations of right ventriculo-arterial coupling in experimental and clinical pulmonary hypertension. Physiological Reports, 7(24), e14322. -
Survival implications of pulmonary hypertension in end-stage COPD
Kapasi, A., Halloran, K., Hirji, A., Lien, D., Mooney, J., Raj, R., … Zamanian, R. (2019). Survival implications of pulmonary hypertension in end-stage COPD. EUROPEAN RESPIRATORY JOURNAL. EUROPEAN RESPIRATORY SOC JOURNALS LTD. -
Late Breaking Abstract - Safety and efficacy of B-cell depletion with rituximab for the treatment of systemic sclerosis-associated pulmonary arterial hypertension
Zamanian, R., Badesch, D., Chung, L., Domsic, R., Medsger, T., Pinckney, A., … Nicolls, M. (2019). Late Breaking Abstract - Safety and efficacy of B-cell depletion with rituximab for the treatment of systemic sclerosis-associated pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL. EUROPEAN RESPIRATORY SOC JOURNALS LTD. -
Elevated pulmonary vascular resistance is associated with increased risk of death in IPF
Kapasi, A., Halloran, K., Hirji, A., Lien, D., Mooney, J., Raj, R., … Zamanian, R. (2019). Elevated pulmonary vascular resistance is associated with increased risk of death in IPF. EUROPEAN RESPIRATORY JOURNAL. EUROPEAN RESPIRATORY SOC JOURNALS LTD. -
Safety and Efficacy of B-cell Depletion with Rituximab for the Treatment of Systemic Sclerosis-associated Pulmonary Arterial Hypertension in a Multi-center NIH Clinical Trial
Nicolls, M., Badesch, D., Chung, L., Domsic, R., Medsger, T., Pinckney, A., … Zamanian, R. (2019). Safety and Efficacy of B-cell Depletion with Rituximab for the Treatment of Systemic Sclerosis-associated Pulmonary Arterial Hypertension in a Multi-center NIH Clinical Trial. ARTHRITIS & RHEUMATOLOGY. WILEY. -
ANATOMIC, GENETIC AND FUNCTIONAL PROPERTIES OF THE RETINAL CIRCULATION IN PULMONARY HYPERTENSION
Nickel, N. P., Shamskhou, E. A., Razeen, M., Condon, D., Messentier, L., Dubra, A., … de Jesus Perez, V. A. (2020). ANATOMIC, GENETIC AND FUNCTIONAL PROPERTIES OF THE RETINAL CIRCULATION IN PULMONARY HYPERTENSION. Pulmonary Circulation. -
Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive IPAH and COVID-19 Infection.
Zamanian, R. T., Pollack, C. V., Gentile, M. A., Rashid, M., Fox, J. C., Mahaffey, K. W., & de Jesus Perez, V. (2020). Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive IPAH and COVID-19 Infection. American Journal of Respiratory and Critical Care Medicine. -
A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with PAH or CTEPH and Impact on the Process of Care.
Lee, J. D., Burger, C. D., Delossantos, G. B., Grinnan, D., Ralph, D. D., Rayner, S. G., … Leary, P. J. (2020). A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with PAH or CTEPH and Impact on the Process of Care. Annals of the American Thoracic Society. -
Derivation of the Pulmonary Hypertension Association Registry Evaluation (PHARE)
Grinnan, D., Kang, L., DeWilde, C., Johnson, D., Chakinala, M. M., Ford, H., … McConnell, J. W. (2020). Derivation of the Pulmonary Hypertension Association Registry Evaluation (PHARE). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Real-World Mono-, Double and Triple Combination Treatment Patterns with Macitentan in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (PAH-CTD): Evidence from the Combined OPUS/OrPHeUS Dataset
Lammi, M. R., Chin, K., Kim, N. H., McLaughlin, V. V., Zamanian, R., Flynn, M., … Channick, R. (2020). Real-World Mono-, Double and Triple Combination Treatment Patterns with Macitentan in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (PAH-CTD): Evidence from the Combined OPUS/OrPHeUS Dataset. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Risk Prediction Models Are Associated with Patient Centered Outcomes in PAH: The Pulmonary Hypertension Association Registry
Min, J., Feldman, J. P., Sager, J. S., Shlobin, O. A., McConnell, J. W., Lammi, M. R., … Al-Naamani, N. (2020). Risk Prediction Models Are Associated with Patient Centered Outcomes in PAH: The Pulmonary Hypertension Association Registry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Heterogeneity in the Treatment of Group 3 Pulmonary Hypertension: Insights from a National Survey
Thomas, C., Manrique, R. J. B., Anderson, R. J., Glinskii, V., Sung, Y. K., Kudelko, K., … Perez, V. D. J. (2020). Heterogeneity in the Treatment of Group 3 Pulmonary Hypertension: Insights from a National Survey. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Litaf-Dependent Pericyte Signaling Perpetuates Vascular Inflammation in Pulmonary Hypertension
Condon, D. F., Shamskhou, K., Nathan, A., Sweatt, A., Chakraborty, A., Agarwal, S., … Perez, V. D. J. (2020). Litaf-Dependent Pericyte Signaling Perpetuates Vascular Inflammation in Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Renin-Angiotensin-Aldosterone System Inhibitor Use and Mortality in Pulmonary Hypertension: Insights from the Veterans Affairs CART Database.
Lahm, T., Hess, E., Barón, A. E., Maddox, T. M., Plomondon, M. E., Choudhary, G., … Leary, P. J. (2020). Renin-Angiotensin-Aldosterone System Inhibitor Use and Mortality in Pulmonary Hypertension: Insights from the Veterans Affairs CART Database. Chest. -
Levosimendan Improves Hemodynamics And Submaximal Exercise Capacity In Ph-hfpef: Primary Results From The Help-ph-hfpef Multicenter Randomized Controlled Trial
Borlaug, B. A., Burkhoff, D., Shah, S., Zolty, R., Tedford, R., Thenappan, T., … Rich, S. (2020). Levosimendan Improves Hemodynamics And Submaximal Exercise Capacity In Ph-hfpef: Primary Results From The Help-ph-hfpef Multicenter Randomized Controlled Trial. JOURNAL OF CARDIAC FAILURE. CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS. -
Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension.
Oh, S., Jang, A. Y., Chae, S., Choi, S., Moon, J., Kim, M., … Chung, W.-J. J. (2021). Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension. Scientific Reports, 11(1), 2012. -
PENet-a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging.
Huang, S.-C. C., Kothari, T., Banerjee, I., Chute, C., Ball, R. L., Borus, N., … Lungren, M. P. (2020). PENet-a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging. NPJ Digital Medicine, 3(1), 61. -
Author Correction: PENet-a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging.
Huang, S.-C. C., Kothari, T., Banerjee, I., Chute, C., Ball, R. L., Borus, N., … Lungren, M. P. (2020). Author Correction: PENet-a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging. NPJ Digital Medicine, 3(1), 102. -
Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis Associated Pulmonary Arterial Hypertension: A Multi-center, Double-blind, Randomized, Placebo-controlled Trial.
Zamanian, R. T., Badesch, D., Chung, L., Domsic, R. T., Medsger, T., Pinckney, A., … Nicolls, M. R. (2021). Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis Associated Pulmonary Arterial Hypertension: A Multi-center, Double-blind, Randomized, Placebo-controlled Trial. American Journal of Respiratory and Critical Care Medicine. -
No Good Deed Goes Unpunished: Mitomycin-Induced Pulmonary Venoocclusive Disease and Cancer.
De Jesus Perez, V. A., & Zamanian, R. T. (2021). No Good Deed Goes Unpunished: Mitomycin-Induced Pulmonary Venoocclusive Disease and Cancer. Chest, 159(3), 910–11.
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Surrogate and combined end points in pulmonary arterial hypertension.
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