Biography
Dr. Cowan has held several nationally elected positions, including chair of the sections on Chronic Daily Headache and In-office Patient Education for the American Headache Society. He is past president of the Headache Cooperative of the Pacific and a fellow of the American Academy of Neurology and the American Headache Society. He has served on the boards of the Alliance for Headache Diseases Advocacy, the Headache Cooperative of the Pacific, the American Headache and Migraine Association, and the American Council for Headache Education.
His research focuses on advancing the understanding of chronic daily headache. He has received grants to support his research from the National Institutes of Health, foundations, and industry, as well as private grants and gifts.
Dr. Cowan is widely published in peer-reviewed journals, including Headache and Neurology. He reviews articles for Headache and other publications and is an editor for Headache Currents. He has authored the book The Keeler Migraine Method and Chronic Daily Headache, as well as multiple textbook chapters.
He has presented his work at meetings of the American Academy of Neurology and International Headache Society, and other organizations, and lectures both nationally and internationally on diverse headache topics. He has appeared on network television and been featured in articles in publications ranging from the San Francisco Chronicle and New York Times to Vogue Magazine.
Dr. Cowan educates the headache specialists of the future as a professor in the School of Medicine, as a senior fellow in the Stanford Center for Innovation in Global Health, and as a mentor for the American Brain Foundation.
He is a member of the American Headache Society, American Academy of Neurology, and Headache Cooperative of the Pacific.
He has volunteered his time and expertise to serve the Alliance for Patient Access, Veterans Administration, and community health programs.
Professional Summary
Education & Certifications
- Medical Education: University of Southern California Keck School of Medicine (1986) CA
- Residency: LACplusUSC Neurology Residency (1990) CA
- Internship: LACplusUSC Medical Center Internal Medicine Residency (1987) CA
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- Board Certification: American Board of Psychiatry and Neurology, Neurology (1994)
- Board Certification, Unified Council of Neurologic Subspecialties, Headache Medicine (2008)
- Board Certification, American Academy of Pain Medicine (2000)
Honors & Awards
- Chief Resident, LAC/USC, Los Angeles, California (1989)
- Fellow, American Academy of Neurology (2006)
- Fellow, American Headache Society (2010)
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- Magna Cum Laude, Clark University, Worcester, Massachusetts (1972)
- Woodrow Wilson Scholar, Clark University, Worcester, Massachusetts (1972)
Memberships
- Member, Board of Directors, Alliance for Headache Disorders Advocacy (2009 - Present)
- Member, Board of Directors, Headache Cooperative of the Pacific (2007 - Present)
- Member, Advisory Committee, NCAA Select committee on headache in collegiate atheletes (2013 - Present)
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- Member,, American Headache Society (1995 - Present)
- Member, American Academy of Neurology (1990 - Present)
- Member, International Headache Society (2010 - Present)
Administrative Appointments
- Betty Higgins Family Foundation Director, Neurology (2017 - Present)
- Chair, Refractory Headache Special Interest Section, American Headache Society, American Headache Society (2012 - 2016)
- Director of Headache Research, Stanford University School of Medicine (2022 - Present)
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- Director,Stanford Headache Program, Stanford University School of Medicine (2011 - 2022)
- President, Headache Cooperative of the Pacific (2012 - 2016)
- Program Director, Headache Cooperative of the Pacific (2007 - 2011)
- Vice President, Headache Cooperative of the Pacific (2007 - 2012)
Publications
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Cerebrospinal Fluid Sodium Increases in Migraine
Cerebrospinal Fluid Sodium Increases in Migraine. (2006). Headache, 46 (7). -
Cerebrospinal fluid phosopholipase C activity increases in migraine.
Cerebrospinal fluid phosopholipase C activity increases in migraine. (2011). Cephalalgia, 31 (4). -
Capillary Endothelial Na+, K+, ATPase Transporter Homeostasis and a New Theory for Migraine Pathophysiology.
Capillary Endothelial Na+, K+, ATPase Transporter Homeostasis and a New Theory for Migraine Pathophysiology. (2010). Headache, 50 (3). -
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The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid.
The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid. (2009). Cerebrospinal Fluid Res. -
Prostaglandin D Synthase Isoforms from Cerebrospinal Fluid Vary with Brain Physiology.
Prostaglandin D Synthase Isoforms from Cerebrospinal Fluid Vary with Brain Physiology. (2006). Disease Markers, 22 (1-2). -
Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study
Fonteh, A. N., Pogoda, J. M., Chung, R., Cowan, R. P., & Harrington, M. G. (2013). Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study. JOURNAL OF HEADACHE AND PAIN, 14. -
Does exercise make migraines worse and tension type headaches better?
Hindiyeh, N. A., Krusz, J. C., & Cowan, R. P. (2013). Does exercise make migraines worse and tension type headaches better? Current Pain and Headache Reports, 17(12), 380-? -
Executive Function Changes before Memory in Preclinical Alzheimer's Pathology: A Prospective, Cross-Sectional, Case Control Study
Harrington, M. G., Chiang, J., Pogoda, J. M., Gomez, M., Thomas, K., Marion, S. D. B., … Fonteh, A. N. (2013). Executive Function Changes before Memory in Preclinical Alzheimer's Pathology: A Prospective, Cross-Sectional, Case Control Study. PLOS ONE, 8(11). -
Prevalence of migraine headache and its weight on neurological burden in Africa: a 43-year systematic review and meta-analysis of community-based studies.
Woldeamanuel, Y. W., Andreou, A. P., & Cowan, R. P. (2014). Prevalence of migraine headache and its weight on neurological burden in Africa: a 43-year systematic review and meta-analysis of community-based studies. Journal of the Neurological Sciences, 342(1-2), 1–15. -
CAM in the Real World: You May Practice Evidence-Based Medicine, But Your Patients Don't.
Cowan, R. P. (2014). CAM in the Real World: You May Practice Evidence-Based Medicine, But Your Patients Don't. Headache, 54(6), 1097–1102. -
Prevalence of migraine headache and its weight on neurological burden in Africa: A 43-year systematic review and Meta-analysis of community-based studies
Woldeamanuel, Y. W., Andreou, A. P., & Cowan, R. P. (2014). Prevalence of migraine headache and its weight on neurological burden in Africa: A 43-year systematic review and Meta-analysis of community-based studies. JOURNAL OF THE NEUROLOGICAL SCIENCES, 342(1-2), 1–15. -
Does exercise make migraines worse and tension type headaches better?
Hindiyeh, N. A., Krusz, J. C., & Cowan, R. P. (2013). Does exercise make migraines worse and tension type headaches better? Current Pain and Headache Reports, 17(12), 380-? -
Comparison of parenteral treatments of acute primary headache in a large academic emergency department cohort.
McCarthy, L. H., & Cowan, R. P. (2015). Comparison of parenteral treatments of acute primary headache in a large academic emergency department cohort. Cephalalgia , 35(9), 807–15. -
Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases.
Peretz, A. M., Woldeamanuel, Y. W., Rapoport, A. M., & Cowan, R. P. (2015). Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases. Cephalalgia . -
The impact of regular lifestyle behavior in migraine: a prevalence case-referent study
Woldeamanuel, Y. W., & Cowan, R. P. (2016). The impact of regular lifestyle behavior in migraine: a prevalence case-referent study. JOURNAL OF NEUROLOGY, 263(4), 669–76. -
Journal Club: Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome.
Woldeamanuel, Y. W., O'Hare, M., DeSouza, D. D., & Cowan, R. P. (2016). Journal Club: Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome. Neurology, 87(16), e196–e198. -
Journal Club: Change in brain network connectivity during PACAP38-induced migraine attacks.
DeSouza, D. D., O'Hare, M., Woldeamanuel, Y. W., & Cowan, R. P. (2016). Journal Club: Change in brain network connectivity during PACAP38-induced migraine attacks. Neurology, 87(16), e199–e202. -
Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004
Pogoda, J. M., Gross, N. B., Arakaki, X., Fonteh, A. N., Cowan, R. P., & Harrington, M. G. (2016). Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004. HEADACHE, 56(4), 688–98. -
Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases
Peretz, A. M., Woldeamanuel, Y. W., Rapoport, A. M., & Cowan, R. P. (2016). Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases. CEPHALALGIA, 36(13), 1257–67. -
Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants
Woldeamanuel, Y. W., & Cowan, R. P. (2017). Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants. JOURNAL OF THE NEUROLOGICAL SCIENCES, 372, 307–15. -
Effect of Educating the Primary Care Physician About Headache to Help Reduce "Trivial" Referrals and Improve the Number and Quality of "Substantial" Referrals that Truly Need Subspecialty Headache Medicine Care.
Cowan, R., & Barad, M. (2017). Effect of Educating the Primary Care Physician About Headache to Help Reduce "Trivial" Referrals and Improve the Number and Quality of "Substantial" Referrals that Truly Need Subspecialty Headache Medicine Care. Current Treatment Options in Neurology, 19(7), 25-? -
Migraine and Complex Regional Pain Syndrome: A Case-Referent Clinical Study.
Woldeamanuel, Y. W., Cooley, C., Foley-Saldena, K., & Cowan, R. P. (2017). Migraine and Complex Regional Pain Syndrome: A Case-Referent Clinical Study. BioMed Research International, 2017, 5714673. -
Migraine Action Plan (MAP).
Peretz, A. M., Minen, M. T., Cowan, R., & Strauss, L. D. (2018). Migraine Action Plan (MAP). Headache, 58(2), 355–56. -
Development of a claims-based algorithm for use in patients with migraine to identify potentially undiagnosed chronic migraine patients
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2017). Development of a claims-based algorithm for use in patients with migraine to identify potentially undiagnosed chronic migraine patients. JOURNAL OF HEADACHE AND PAIN, 18. -
Introducing the Migraine Action Plan
Peretz, A. M., Minen, M. T., Cowan, R., & Strauss, L. D. (2018). Introducing the Migraine Action Plan. HEADACHE, 58(2), 195. -
Interactions between affective measures and amygdala volume in chronic migraine: associations in the absence of group volumetric differences
Desouza, D. D., Woldeamanuel, Y. W., Peretz, A. M., Sanjanwala, B. M., & Cowan, R. P. (2017). Interactions between affective measures and amygdala volume in chronic migraine: associations in the absence of group volumetric differences. CEPHALALGIA, 37, 47–48. -
Deep Brain Stimulation for Chronic Cluster Headache: A Review.
Vyas, D. B., Ho, A. L., Dadey, D. Y., Pendharkar, A. V., Sussman, E. S., Cowan, R., & Halpern, C. H. (2018). Deep Brain Stimulation for Chronic Cluster Headache: A Review. Neuromodulation : Journal of the International Neuromodulation Society. -
The Future of Migraine Prevention.
Cowan, R. P. (2018). The Future of Migraine Prevention. Headache. -
Obesity-Related Cortical Thickness Changes in Chronic Migraine
Woldeamanuel, Y. W., DeSouza, D. D., Sanjanwala, B. M., & Cowan, R. P. (2018). Obesity-Related Cortical Thickness Changes in Chronic Migraine. ANNALS OF NEUROLOGY, 84, S83. -
American Headache Society Survey About Urgent and Emergency Management of Headache Patients
Minen, M. T., Ortega, E., Lipton, R. B., & Cowan, R. (2018). American Headache Society Survey About Urgent and Emergency Management of Headache Patients. HEADACHE, 58(9), 1389–96. -
Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine - A Pilot Study.
Woldeamanuel, Y. W., DeSouza, D. D., Sanjanwala, B. M., & Cowan, R. P. (2018). Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine - A Pilot Study. Headache. -
The impact of offering monthly and quarterly dosing options for a new class of migraine preventive therapy on likelihood of acceptance and adherence in adults with migraine (vol 19, pg P137, 2018)
Cowan, R., Cohen, J., Rosenman, E., Fitzgerald, T., & Iyer, R. (2018). The impact of offering monthly and quarterly dosing options for a new class of migraine preventive therapy on likelihood of acceptance and adherence in adults with migraine (vol 19, pg P137, 2018). JOURNAL OF HEADACHE AND PAIN, 19. -
Evaluation of the Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group
Yu, J. S., Pavlovic, J. M., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2018). Evaluation of the Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group. NEUROLOGY, 90. -
American Headache Society Survey about Urgent and Emergency Management of Headache Patients
Minen, M., Ortega, E., Lipton, R., & Cowan, R. (2018). American Headache Society Survey about Urgent and Emergency Management of Headache Patients. NEUROLOGY, 90. -
Development of a Claims-Based Algorithm for Use in Patients with Migraine to Identify Potentially Undiagnosed Chronic Migraine Patients
Pavlovic, J., Yu, J. S., Silbertsein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2018). Development of a Claims-Based Algorithm for Use in Patients with Migraine to Identify Potentially Undiagnosed Chronic Migraine Patients. NEUROLOGY, 90. -
Migraine Treatment Patterns and Opioid Use Among Chronic and Episodic Migraine Patients Identified by a Clinician-Administered Semi-Structured Diagnostic Interview
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2018). Migraine Treatment Patterns and Opioid Use Among Chronic and Episodic Migraine Patients Identified by a Clinician-Administered Semi-Structured Diagnostic Interview. NEUROLOGY, 90. -
The impact on physician prescribing of monthly and quarterly dosing options for a new class of migraine preventive therapy
Cowan, R., Rosenman, E., Fitzgerald, T., Cohen, J., & Iyer, R. (2018). The impact on physician prescribing of monthly and quarterly dosing options for a new class of migraine preventive therapy. JOURNAL OF HEADACHE AND PAIN. SPRINGEROPEN. -
The impact of offering monthly and quarterly dosing options for a new class of migraine preventive therapy on likelihood of acceptance and adherence in adults with migraine
Cowan, R., Cohen, J., Rosenman, E., Fitzgerald, T., & Iyer, R. (2018). The impact of offering monthly and quarterly dosing options for a new class of migraine preventive therapy on likelihood of acceptance and adherence in adults with migraine. JOURNAL OF HEADACHE AND PAIN. SPRINGEROPEN. -
Evaluation of the 6-Item Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2018). Evaluation of the 6-Item Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group. JOURNAL OF HEADACHE AND PAIN, 19. -
Development of a claims-based algorithm to identify potentially undiagnosed chronic migraine patients.
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2019). Development of a claims-based algorithm to identify potentially undiagnosed chronic migraine patients. Cephalalgia : an International Journal of Headache, 333102418825373. -
Worldwide Migraine Epidemiology: Systematic Review and Meta-Analysis of 302 Community-Based Studies Involving 6,216,995 Participants
Woldeamanuel, Y., & Cowan, R. (2016). Worldwide Migraine Epidemiology: Systematic Review and Meta-Analysis of 302 Community-Based Studies Involving 6,216,995 Participants. NEUROLOGY, 86. -
Migraine Treatment Patterns and Opioid Use Among Chronic and Episodic Migraine Patients Identified by a Clinician-Administered Semi-Structured Diagnostic Interview
Yu, J. S., Pavlovic, J. M., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2017). Migraine Treatment Patterns and Opioid Use Among Chronic and Episodic Migraine Patients Identified by a Clinician-Administered Semi-Structured Diagnostic Interview. CEPHALALGIA, 37, 365–66. -
Use of Most Bothersome Symptom as a Co-Primary Endpoint in an Acute Treatment of Migraine Trial
Dodick, D. W., Tepper, S. J., Friedaman, D., Gelfand, A., Cowan, R. P., Schmidt, P., … Kellerman, D. J. (2017). Use of Most Bothersome Symptom as a Co-Primary Endpoint in an Acute Treatment of Migraine Trial. CEPHALALGIA. SAGE PUBLICATIONS LTD. -
Evaluation of the Identify Chronic Migraine (ID-CM) screener in an accountable care organization
Yu, J. S., Pavlovic, J. M., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2017). Evaluation of the Identify Chronic Migraine (ID-CM) screener in an accountable care organization. CEPHALALGIA, 37, 188–89. -
Comprehensive Headache Experience in Collegiate Student-Athletes: An Initial Report From the NCAA Headache Task Force
Seifert, T., Sufrinko, A., Cowan, R., Black, W. S., Watson, D., Edwards, B., … Kontos, A. P. (2017). Comprehensive Headache Experience in Collegiate Student-Athletes: An Initial Report From the NCAA Headache Task Force. HEADACHE, 57(6), 877–86. -
Migraine and Complex Regional Pain Syndrome: A Case-Referent Clinical Study
Woldeamanuel, Y. W., Cooley, C., Foley-Saldena, K., & Cowan, R. P. (2016). Migraine and Complex Regional Pain Syndrome: A Case-Referent Clinical Study. ANNALS OF NEUROLOGY, 80, S169. -
Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004: A Response
Pogoda, J. M., Gross, N. B., Arakaki, X., Fonteh, A. N., Cowan, R. P., & Harrington, M. G. (2016). Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004: A Response. HEADACHE, 56(7), 1216–18. -
Chronic daily headache
Cowan, R. P. (2013). Chronic daily headache. NEUROPSYCHIATRY OF HEADACHE, 95–105. -
Toward a Philosophy of Migraine.
Cowan, R. P. (2019). Toward a Philosophy of Migraine. Headache, 59(4), 481–83. -
Physician and patient preferences for dosing options in migraine prevention.
Cowan, R., Cohen, J. M., Rosenman, E., & Iyer, R. (2019). Physician and patient preferences for dosing options in migraine prevention. The Journal of Headache and Pain, 20(1), 50. -
Toward a Philosophy of Migraine
Cowan, R. P. (2019). Toward a Philosophy of Migraine. HEADACHE, 59(4), 481–83. -
Physician and patient preferences for dosing options in migraine prevention
Cowan, R., Cohen, J. M., Rosenman, E., & Iyer, R. (2019). Physician and patient preferences for dosing options in migraine prevention. JOURNAL OF HEADACHE AND PAIN, 20. -
Subarachnoid Hemorrhage and Headache.
Ogunlaja, O. I., & Cowan, R. (2019). Subarachnoid Hemorrhage and Headache. Current Pain and Headache Reports, 23(6), 44. -
Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation.
Gross, N. B., Abad, N., Lichtstein, D., Taron, S., Aparicio, L., Fonteh, A. N., … Harrington, M. G. (2019). Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation. PloS One, 14(6), e0218041. -
Deep Brain Stimulation for Chronic Cluster Headache: A Review
Vyas, D. B., Ho, A. L., Dadey, D. Y., Pendharkar, A. V., Sussman, E. S., Cowan, R., & Halpern, C. H. (2019). Deep Brain Stimulation for Chronic Cluster Headache: A Review. NEUROMODULATION, 22(4), 388–97. -
Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications.
Rapoport, A. M., Bonner, J. H., Lin, T., Harris, D., Gruper, Y., Ironi, A., & Cowan, R. P. (2019). Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications. The Journal of Headache and Pain, 20(1), 83. -
The Future of Migraine Prevention
Cowan, R. P. (2018). The Future of Migraine Prevention. HEADACHE, 58, 291–97. -
Altered Permeability Blood-CSF of Barriers in Migraine
Cowan, R., Sweeney, M., Sagare, A., Ekpo, E., Sanjanwala, B., Gross, N., … Harrington, M. (2019). Altered Permeability Blood-CSF of Barriers in Migraine. NEUROLOGY, 92(15). -
Exploring Natural Cohorts of Chronic Migraine Phenotype
Woldeamanuel, Y., Sanjanwala, B., Peretz, A., & Cowan, R. (2019). Exploring Natural Cohorts of Chronic Migraine Phenotype. NEUROLOGY, 92(15). -
The Impact of Offering Monthly and Quarterly Dosing Options for a New Class of Migraine Preventive Therapy on Likelihood of Acceptance and Adherence in Adults With Migraine
Cowan, R., Cohen, J., Rosenman, E., & Iyer, R. (2019). The Impact of Offering Monthly and Quarterly Dosing Options for a New Class of Migraine Preventive Therapy on Likelihood of Acceptance and Adherence in Adults With Migraine. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Patient preference for and satisfaction with fremanezumab following completion of a 1-year extension study
Cowan, R. P., Gandhi, S. K., Cohen, J. M., Cloud, B., Buse, D. C., Ramirez-Campos, V., … Lipton, R. B. (2019). Patient preference for and satisfaction with fremanezumab following completion of a 1-year extension study. CEPHALALGIA. SAGE PUBLICATIONS LTD. -
Patient preference for dosing regimen and perception of dosing flexibility with fremanezumab for migraine: results from a patient survey following completion of a 1-year extension study
Cowan, R. P., Gandhi, S. K., Cloud, B., Cohen, J. M., Buse, D. C., Ramirez-Campos, V., … Lipton, R. B. (2019). Patient preference for dosing regimen and perception of dosing flexibility with fremanezumab for migraine: results from a patient survey following completion of a 1-year extension study. CEPHALALGIA. SAGE PUBLICATIONS LTD. -
Evaluation of the 6-Item Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2019). Evaluation of the 6-Item Identify Chronic Migraine (ID-CM) Screener in a Large Medical Group. CEPHALALGIA, 39, 283–84. -
On Making a Headache Medicine Rotation Mandatory in Neurology Training.
Zhang, N., & Cowan, R. P. (2019). On Making a Headache Medicine Rotation Mandatory in Neurology Training. Headache. -
Endogenous Glucocorticoids may be Potential Biomarkers for Migraine Chronification
Woldeamanuel, Y. W., Sanjanwala, B. M., & Cowan, R. P. (2019). Endogenous Glucocorticoids may be Potential Biomarkers for Migraine Chronification. CEPHALALGIA, 39(1_SUPPL), 379–80. -
Aberrant Structural Network Architecture in Chronic Migraine
DeSouza, D. D., Woldeamanuel, Y. W., Sanajanwala, B. M., Bissell, D., Bishop, J. H., & Cowan, R. P. (2019). Aberrant Structural Network Architecture in Chronic Migraine. CEPHALALGIA, 39(1_SUPPL), 392. -
Altered structural brain network topology in chronic migraine.
DeSouza, D. D., Woldeamanuel, Y. W., Sanjanwala, B. M., Bissell, D. A., Bishop, J. H., Peretz, A., & Cowan, R. P. (2019). Altered structural brain network topology in chronic migraine. Brain Structure & Function. -
ACEP Guidelines on Acute Nontraumatic Headache Diagnosis and Management in the Emergency Department, Commentary on Behalf of the Refractory, Inpatient, Emergency Care Section of the American Headache Society.
Peretz, A., Dujari, S., Cowan, R., & Minen, M. (2020). ACEP Guidelines on Acute Nontraumatic Headache Diagnosis and Management in the Emergency Department, Commentary on Behalf of the Refractory, Inpatient, Emergency Care Section of the American Headache Society. Headache. -
Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study.
Woldeamanuel, Y. W., Sanjanwala, B. M., Peretz, A. M., & Cowan, R. P. (2020). Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study. Scientific Reports, 10(1), 2804. -
Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture.
Chan, T. L., Cowan, R., Hindiyeh, N., Hashmi, S., Lanzman, B., & Carroll, I. (2020). Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture. BMC Neurology, 20(1), 162. -
Calcitonin Gene-Related Peptide Receptor Antagonists (Gepants) for the Acute Treatment of Nausea in Episodic Migraine: A Systematic Review and Meta-Analysis.
Chan, T. L., Cowan, R. P., & Woldeamanuel, Y. W. (2020). Calcitonin Gene-Related Peptide Receptor Antagonists (Gepants) for the Acute Treatment of Nausea in Episodic Migraine: A Systematic Review and Meta-Analysis. Headache. -
Insights into chronic migraine pathophysiology - what measures of gray matter reveal.
DeSouza, D. D., & Cowan, R. P. (2020). Insights into chronic migraine pathophysiology - what measures of gray matter reveal. Cephalalgia : an International Journal of Headache, 333102420933263. -
Electrophysiology and Structural Connectivity of the Posterior Hypothalamic Region: Much to Learn From a Rare Indication of Deep Brain Stimulation.
Kakusa, B., Saluja, S., Dadey, D. Y., Barbosa, D. A., Gattas, S., Miller, K. J., … Halpern, C. H. (2020). Electrophysiology and Structural Connectivity of the Posterior Hypothalamic Region: Much to Learn From a Rare Indication of Deep Brain Stimulation. Frontiers in Human Neuroscience, 14, 164. -
Endogenous glucocorticoids may serve as biomarkers for migraine chronification
Woldeamanuel, Y. W., Sanjanwala, B. M., & Cowan, R. P. (2020). Endogenous glucocorticoids may serve as biomarkers for migraine chronification. Therapeutic Advances in Chronic Disease, 11. -
Cerebrospinal Fluid Leak in the context of Pars Interarticularis Fracture: A Case Series
Chan, L. H. T., Cowan, R., Hindiyeh, N., Hashmi, S., Lanzman, B., & Carroll, I. (2020). Cerebrospinal Fluid Leak in the context of Pars Interarticularis Fracture: A Case Series. NEUROLOGY, 94(15). -
Patient Preference for Dosing Regimen and Perception of Dosing Flexibility With Fremanezumab for Migraine: Results From a Patient Survey Following Completion of a 1-Year Extension Study
Cowan, R. P., Gandhi, S. K., Cloud, B., Cohen, J. M., Buse, D. C., Ramirez-Campos, V., … Lipton, R. B. (2020). Patient Preference for Dosing Regimen and Perception of Dosing Flexibility With Fremanezumab for Migraine: Results From a Patient Survey Following Completion of a 1-Year Extension Study. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Improvements across a range of patient-reported domains with fremanezumab treatment: results from a patient survey study.
Buse, D. C., Gandhi, S. K., Cohen, J. M., Ramirez-Campos, V., Cloud, B., Yang, R., & Cowan, R. P. (2020). Improvements across a range of patient-reported domains with fremanezumab treatment: results from a patient survey study. The Journal of Headache and Pain, 21(1), 109. -
Reimagining Headache Fellowships.
Zhang, N., Chan, T. L., & Cowan, R. (2020). Reimagining Headache Fellowships. Headache. -
Endogenous glucocorticoids may serve as biomarkers for migraine chronification.
Woldeamanuel, Y. W., Sanjanwala, B. M., & Cowan, R. P. (2020). Endogenous glucocorticoids may serve as biomarkers for migraine chronification. Therapeutic Advances in Chronic Disease, 11, 2040622320939793. -
Moving the Needle: Desiloing the Stakeholders in the Headache Space.
Cowan, R. P. (2020). Moving the Needle: Desiloing the Stakeholders in the Headache Space. Headache, 60(9), 2041. -
Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine - A Pilot Study
Woldeamanuel, Y. W., DeSouza, D. D., Sanjanwala, B. M., & Cowan, R. P. (2019). Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine - A Pilot Study. HEADACHE, 59(2), 180–91. -
Efficacy, tolerability, and safety of eptinezumab in patients with a dual diagnosis of chronic migraine and medication-overuse headache: Subgroup analysis of PROMISE-2.
Diener, H.-C., Marmura, M. J., Tepper, S. J., Cowan, R., Starling, A. J., Diamond, M. L., … Cady, R. (2020). Efficacy, tolerability, and safety of eptinezumab in patients with a dual diagnosis of chronic migraine and medication-overuse headache: Subgroup analysis of PROMISE-2. Headache. -
Evaluation of the 6-item Identify Chronic Migraine screener in a large medical group.
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Cowan, R. P., Dabbous, F., … Lipton, R. B. (2021). Evaluation of the 6-item Identify Chronic Migraine screener in a large medical group. Headache. -
Estimating the Economic Burden of Migraine on US Employers
Yucel, A., Thach, A., Kumar, S., Loden, C., Bensink, M., Goldfarb, N., & Cowan, R. (2020). Estimating the Economic Burden of Migraine on US Employers. AMERICAN JOURNAL OF MANAGED CARE, 26(12), E403-+. -
Neuropathic pain in Mali: The current situation, comprehensive hypothesis, which therapeutic strategy for Africa?
Maiga, Y., Sangho, O., Konipo, F., Diallo, S., Coulibaly, S. D., Sangare, M., … Nizard, J. (2021). Neuropathic pain in Mali: The current situation, comprehensive hypothesis, which therapeutic strategy for Africa? ENeurologicalSci, 22, 100312. -
A patient perspective of complementary and integrative medicine (CIM) for migraine treatment: a social media survey.
Kuruvilla, D. E., Mehta, A., Ravishankar, N., & Cowan, R. P. (2021). A patient perspective of complementary and integrative medicine (CIM) for migraine treatment: a social media survey. BMC Complementary Medicine and Therapies, 21(1), 58. -
Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen.
Cowan, R. P., Gross, N. B., Sweeney, M. D., Sagare, A. P., Montagne, A., Arakaki, X., … Harrington, M. G. (2021). Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache. -
Development of a claims-based algorithm to identify potentially undiagnosed chronic migraine patients
Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., … Lipton, R. B. (2019). Development of a claims-based algorithm to identify potentially undiagnosed chronic migraine patients. CEPHALALGIA, 39(4), 465–476. -
A new hypothesis linking oxytocin to menstrual migraine.
Bharadwaj, V. N., Porreca, F., Cowan, R. P., Kori, S., Silberstein, S. D., & Yeomans, D. C. (2021). A new hypothesis linking oxytocin to menstrual migraine. Headache. -
Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine.
Castor, K., Dawlaty, J., Arakaki, X., Gross, N., Woldeamanuel, Y. W., Harrington, M. G., … Fonteh, A. N. (2021). Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine. Frontiers in Molecular Neuroscience, 14, 691733. -
Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication-overuse headache.
Marmura, M. J., Diener, H.-C., Cowan, R. P., Tepper, S. J., Diamond, M. L., Starling, A. J., … Cady, R. (2021). Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication-overuse headache. Headache. -
Understanding the Impact of Sex and Race on the Migraine Patient's Journey in the United States: Analyses From an Annual Cross-Sectional Patient Chart Audit
Cowan, R., Stabb, M., Robinson, N., & Schobel, V. (2021). Understanding the Impact of Sex and Race on the Migraine Patient's Journey in the United States: Analyses From an Annual Cross-Sectional Patient Chart Audit. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Altered Functional Network Connectivity in Chronic Migraine: a Replication-Extension Study
DeSouza, D., Hindiyeh, N., Sanjanwala, B., Krimmel, S., Seminowicz, D., & Cowan, R. (2021). Altered Functional Network Connectivity in Chronic Migraine: a Replication-Extension Study. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Computerized migraine diagnostic tools: a systematic review
Woldeamanuel, Y. W., & Cowan, R. P. (2022). Computerized migraine diagnostic tools: a systematic review. Therapeutic Advances in Chronic Disease. . -
PREDICTIVE ENRICHMENT TO IDENTIFY RESPONSE TO SLEEP INTERVENTION IN CANCER SURVIVORS WITH HEADACHE - A PRECISION MEDICINE STUDY
Woldeamanuel, Y. W., Kushida, C. A., Kesler, S., Jo, B., Neri, E., Edwards, K. S., … Palesh, O. (2022). PREDICTIVE ENRICHMENT TO IDENTIFY RESPONSE TO SLEEP INTERVENTION IN CANCER SURVIVORS WITH HEADACHE - A PRECISION MEDICINE STUDY. ANNALS OF BEHAVIORAL MEDICINE. OXFORD UNIV PRESS INC. -
Diagnostic accuracy of an artificial intelligence online engine in migraine: A multi-center study.
Cowan, R. P., Rapoport, A. M., Blythe, J., Rothrock, J., Knievel, K., Peretz, A. M., … Woldeamanuel, Y. W. (2022). Diagnostic accuracy of an artificial intelligence online engine in migraine: A multi-center study. Headache. -
Three Dimensions of Association Link Migraine Symptoms and Functional Connectivity.
Krimmel, S. R., DeSouza, D. D., Keaser, M. L., Sanjanwala, B. M., Cowan, R. P., Lindquist, M. A., … Seminowicz, D. A. (2022). Three Dimensions of Association Link Migraine Symptoms and Functional Connectivity. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. -
Clinical benefits and economic cost-savings of remote electrical neuromodulation (REN) for migraine prevention.
Cowan, R., Stark-Inbar, A., Rabany, L., Harris, D., Vizel, M., Ironi, A., … Treppendahl, C. (2023). Clinical benefits and economic cost-savings of remote electrical neuromodulation (REN) for migraine prevention. Journal of Medical Economics, 26(1), 656–664. -
Significant reduction in migraine days with Remote Electrical Neuromodulation (REN) for migraine prevention: A double-blind randomized sham-controlled clinical trial
Tepper, S., Rabany, L., Cowan, R., Smith, T., Grosberg, B., Torphy, B., … Blumenfeld, A. (2023). Significant reduction in migraine days with Remote Electrical Neuromodulation (REN) for migraine prevention: A double-blind randomized sham-controlled clinical trial. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Preventive Treatment With Eptinezumab in Patients With a Dual Diagnosis of Chronic Migraine and Medication- Overuse Headache: Subgroup Analysis of PROMISE-2
Marmura, M. J., Diener, H.-C., Cowan, R. P., Starling, A. J., Hirman, J., Brevig, T., & Cady, R. (2023). Preventive Treatment With Eptinezumab in Patients With a Dual Diagnosis of Chronic Migraine and Medication- Overuse Headache: Subgroup Analysis of PROMISE-2. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Asynchronous Telemedicine Platform Associated with Decreased Migraine-Related Emergency Room and Urgent Care Use
Crystal, S., Mauskop, A., Rapoport, A., Cowan, R., Bain, P., Kiarashi, J., … Parikh, N. (2023). Asynchronous Telemedicine Platform Associated with Decreased Migraine-Related Emergency Room and Urgent Care Use. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
A Telemedicine Platform to Increase Access to Migraine Care in Men
Crystal, S., Mauskop, A., Rapoport, A., Cowan, R., Bain, P., Kiarashi, J., … Parikh, N. (2023). A Telemedicine Platform to Increase Access to Migraine Care in Men. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Time It Right! The Application of Circadian Medicine Interventions for the Management of Migraine
Woldeamanuel, Y. W., Palesh, O., & Cowan, R. P. (2023). Time It Right! The Application of Circadian Medicine Interventions for the Management of Migraine. ANNALS OF NEUROLOGY. WILEY. -
Diagnosis and Treatment of Spontaneous Intracranial Hypotension: Role of Epidural Blood Patching.
Callen, A. L., Friedman, D. I., Parikh, S., Rau, J. C., Schievink, W. I., Cutsforth-Gregory, J. K., … Carroll, I. (2024). Diagnosis and Treatment of Spontaneous Intracranial Hypotension: Role of Epidural Blood Patching. Neurology. Clinical Practice, 14(3), e200290. -
Long-Term Epidural Patching Outcomes and Predictors of Benefit in Patients With Suspected CSF Leak Nonconforming to ICHD-3 Criteria.
Carroll, I., Han, L., Zhang, N., Cowan, R. P., Lanzman, B., Hashmi, S., … Callen, A. L. (2024). Long-Term Epidural Patching Outcomes and Predictors of Benefit in Patients With Suspected CSF Leak Nonconforming to ICHD-3 Criteria. Neurology, 102(12), e209449. -
Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?
Bharadwaj, V. N., Klukinov, M., Cowan, R. P., Mahinparvar, N., Clark, D. J., & Yeomans, D. C. (2024). Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache? Pharmaceutics, 16(6). -
The burden of headache and a health-care needs assessment in the adult population of Mali: a cross-sectional population-based study.
Maiga, Y., Diallo, S. H., Sangho, O., Moskatel, L. S., Konipo, F., Bocoum, A., … Husøy, A. A. (2024). The burden of headache and a health-care needs assessment in the adult population of Mali: a cross-sectional population-based study. The Journal of Headache and Pain, 25(1), 107. -
Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine.
Woldeamanuel, Y. W., Sanjanwala, B. M., & Cowan, R. P. (2024). Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine. Therapeutic Advances in Chronic Disease, 15, 20406223241274302. -
Assessing traditional medicine in the treatment of neurological disorders in Mali: prelude to efficient collaboration.
Maiga, Y., Moskatel, L. S., Diallo, S. H., Sangho, O., Dolo, H., Konipo, F., … Nizard, J. (2024). Assessing traditional medicine in the treatment of neurological disorders in Mali: prelude to efficient collaboration. BMC Complementary Medicine and Therapies, 24(1), 352.
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The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid.
Clinical Trials
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Headache Clinic Palo Alto, CA
Palo Alto, CAHeadache Clinic
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Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereFacial Pain Program at the Neuroscience Health Center Palo Alto, CA
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213 Quarry Rd
Palo Alto , CA 94304
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