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David Miklos, M.D., Ph.D.
Blood and marrow transplant specialist, Hematologist, Medical oncologist
Associate Professor of Medicine (Blood and Marrow Transplantation) at the Stanford University Medical Center
Bio:
I am a physician-scientist who has established a human translational research group that fosters the development of both laboratory immunologists, and clinical translational researchers. Allogeneic hematopoietic cell transplantation (alloHCT) cures blood cancer via beneficial graft-v-tumor immunity. Our overall research goal is to augment GVT while preventing dertimental graft versus host disease (GVHD). The Miklos lab pioneered protein microarray technologies to disciiver clinically relevant allogeneic antibodies, especially those targeting H-Y antigens following sex mismatched transplantation. Our discovery that allogeneic HY antibodies develop in association with chronic GVHD revealed a critical B cell role in chronic GVHD pathogenesis and our clinical trials established cGVHD therapeutic benefits using anti-B cell drugs rituximab and ibrutinib. We developed high-throughput sequencing of the B and T cell immune receptor thereby enabling: 1) lymphoid disease quantification, 2) detailed B and T cell donor reconstitution kinetics, and 3) clonal analysis of antigen specific responses following allo-HCT.
Immunotherapy is revolutionizing cancer treatment and as the Stanford Clinical Cancer Cell Therapy program develops and evaluates the most promising cutting-edge cell therapies for cancer patients on a variety of clinical trials. Chimeric Antigen T Cell (CAR-T) therapy targets the patient's T lymphocytes to attack their cancer by infecting their own T cells to express chimeric antigen receptor (CAR) proteins that target and kill cancer cell expressing surface proteins. Thus far, the most successful CAR-T have targeted B cell antigen CD19, and ongoing trials are treating patients with relapsed/refractory Diffuse Large B Cell Lymphoma (DLBCL) using this CAR19 therapy.
Immunotherapy is revolutionizing cancer treatment and as the Stanford Clinical Cancer Cell Therapy program develops and evaluates the most promising cutting-edge cell therapies for cancer patients on a variety of clinical trials. Chimeric Antigen T Cell (CAR-T) therapy targets the patient's T lymphocytes to attack their cancer by infecting their own T cells to express chimeric antigen receptor (CAR) proteins that target and kill cancer cell expressing surface proteins. Thus far, the most successful CAR-T have targeted B cell antigen CD19, and ongoing trials are treating patients with relapsed/refractory Diffuse Large B Cell Lymphoma (DLBCL) using this CAR19 therapy.
- 875 Blake Wilbur Drive
- Clinic E, 1st Floor
- Palo Alto , CA 94304
- Phone: 650-723-0822
- 875 Blake Wilbur Drive
- Clinic F
- Palo Alto , CA 94304
- Phone: 650-498-6000
- 875 Blake Wilbur Drive
- Palo Alto , CA 94304
- Phone: 650-498-6000
Practice Areas
- Anemia
- Apheresis
- Aplastic Anemia
- Blood and Bone Marrow Transplant
- Blood Test
- Bone Marrow Aspiration and Biopsy
- Cellular Immunotherapy
- Chemotherapy
- Essential Thrombocythemia (ET)
- Hairy Cell Leukemia
- Hemophilia
Professional Education
- Medical Education: Yale University Office of the Registrar (1995) CT
- Fellowship: Dana Farber Cancer Institute Hematology Oncology Fellowship (2001) MA
- Residency: Brigham and Women's Hospital Harvard Medical School (1998) MA
- Internship: Brigham and Women's Hospital Harvard Medical School (1996) MA
- B.S., University of Notre Dame (1987)
- M.D., Yale University Medical School (1995)
- Ph.D., Yale University, Genetics (1995)
Honors & Awards
- Alpha Omega Alpha, Yale Medical School (1995)
- Clinical Investigator Training Program Scholar, Harvard Medical School (2001-2003)
- Medical Scientist Training Fellow, NIH (1993-1995)
- Phi Betta Kappa, University of Notre Dame (1987)
- Predoctoral Fellow, Howard Hughes Medical Institute (1989-1993)
Administrative Appointments
- Clinical Director Cancer Cell Therapy, Stanford University (2016 - Present)
- Medical Director of Stanford Cellular Therapeutics and Transplantation Laboratory, Stanford University (2011 - 2016)
Publications
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Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors
Miklos, D. B., Kim, H. T., Zorn, E., Hochberg, E. P., Guo, L. X., Mattes-Ritz, A., … Ritz, J. (2004). Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors. BLOOD, 103(1), 353–359. -
Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission
Miklos, D. B., Kim, H. T., Miller, K. H., Guo, L. X., Zorn, E., Lee, S. J., … Ritz, J. (2005). Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission. BLOOD, 105(7), 2973–2978. -
Renal pathology in hematopoietic cell transplantation recipients
Troxell, M. L., Pilapil, M., Miklos, D. B., Higgins, J. P., & Kambham, N. (2008). Renal pathology in hematopoietic cell transplantation recipients. MODERN PATHOLOGY, 21(4), 396–406. -
H-Y antibody development associates with acute rejection in female patients with male kidney transplants
Tan, J. C., Wadia, P. P., Coram, M., Grumet, F. C., Kambham, N., Miller, K., … Miklos, D. B. (2008). H-Y antibody development associates with acute rejection in female patients with male kidney transplants. TRANSPLANTATION, 86(1), 75–81.
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Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation
Wadia, P. P., Coram, M., Armstrong, R. J., Mindrinos, M., Butte, A. J., & Miklos, D. B. (2010). Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation. BLOOD, 115(10), 2077–2087.
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Rituximab in hematopoietic cell transplantation
Arai, S., & Miklos, D. B. (2010). Rituximab in hematopoietic cell transplantation. EXPERT OPINION ON BIOLOGICAL THERAPY, 10(6), 971–982.
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Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements
Boyd, S. D., Gaeta, B. A., Jackson, K. J., Fire, A. Z., Marshall, E. L., Merker, J. D., … Collins, A. M. (2010). Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements. JOURNAL OF IMMUNOLOGY, 184(12), 6986–6992.
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Complete donor T-cell engraftment 30 days after allogeneic transplantation predicts molecular remission in high-risk chronic lymphocytic leukaemia
Jones, C. D., Arai, S., Lowsky, R., Tyan, D. B., Zehnder, J. L., & Miklos, D. B. (2010). Complete donor T-cell engraftment 30 days after allogeneic transplantation predicts molecular remission in high-risk chronic lymphocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 150(5), 637–639.
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Allogeneic T cells impair engraftment and hematopoiesis after stem cell transplantation.
Müller, A. M. S., Linderman, J. A., Florek, M., Miklos, D., & Shizuru, J. A. (2010). Allogeneic T cells impair engraftment and hematopoiesis after stem cell transplantation. Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14721–14726.
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Protein Microarrays Discover Angiotensinogen and PRKRIP1 as Novel Targets for Autoantibodies in Chronic Renal Disease
Butte, A. J., Sigdel, T. K., Wadia, P. P., Miklos, D. B., & Sarwal, M. M. (2011). Protein Microarrays Discover Angiotensinogen and PRKRIP1 as Novel Targets for Autoantibodies in Chronic Renal Disease. MOLECULAR & CELLULAR PROTEOMICS, 10(3).
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Clonally identical Hodgkin's disease develops after allogeneic hematopoietic cell transplant for CLL
Tseng, D., Jones, C. D., Anderson, M., Warnke, R., Zehnder, J. L., & Miklos, D. B. (2011). Clonally identical Hodgkin's disease develops after allogeneic hematopoietic cell transplant for CLL. BONE MARROW TRANSPLANTATION, 46(12), 1576–1578.
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Recombinant antigen microarrays for serum/plasma antibody detection.
Wadia, P. P., Sahaf, B., & Miklos, D. B. (2011). Recombinant antigen microarrays for serum/plasma antibody detection. Methods in Molecular Biology (Clifton, N.J.), 723, 81–104.
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., … Engleman, E. G. (2011). B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. NATURE MEDICINE, 17(5), 610–U134.
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Combined CD4 T-Cell and Antibody Response to Human Minor Histocompatibility Antigen DBY After Allogeneic Stem-Cell Transplantation
Porcheray, F., Miklos, D. B., Floyd, B. H., Sarantopoulos, S., Bellucci, R., Soiffer, R. J., … Zorn, E. (2011). Combined CD4 T-Cell and Antibody Response to Human Minor Histocompatibility Antigen DBY After Allogeneic Stem-Cell Transplantation. TRANSPLANTATION, 92(3), 359–365.
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A phase 1 study of imatinib for corticosteroid-dependent/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies
Chen, G. L., Arai, S., Flowers, M. E. D., Otani, J. M., Qiu, J., Cheng, E. C., … Miklos, D. B. (2011). A phase 1 study of imatinib for corticosteroid-dependent/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies. BLOOD, 118(15), 4070–4078.
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H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births
Nielsen, H. S., Wu, F., Aghai, Z., Steffensen, R., van Halteren, A. G., Spierings, E., … Goulmy, E. (2010). H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births. HUMAN REPRODUCTION, 25(11), 2745–2752.
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Humoral Immunity to Cytomegalovirus and Chronic Graft-Versus-Host Disease
Namboodiri, A. M., Nietert, P. J., Wadia, P. P., Miklos, D. B., & Pandey, J. P. (2012). Humoral Immunity to Cytomegalovirus and Chronic Graft-Versus-Host Disease. VIRAL IMMUNOLOGY, 25(4), 338–340.
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B Cells and Transplantation: An Educational Resource
Small, T. N., Robinson, W. H., & Miklos, D. B. (2009). B Cells and Transplantation: An Educational Resource. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 15(1), 104–113.
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Total lymphoid irradiation-antithymocyte globulin conditioning and allogeneic transplantation for patients with myelodysplastic syndromes and myeloproliferative neoplasms.
Benjamin, J., Chhabra, S., Kohrt, H. E., Lavori, P., Laport, G. G., Arai, S., … Lowsky, R. (2014). Total lymphoid irradiation-antithymocyte globulin conditioning and allogeneic transplantation for patients with myelodysplastic syndromes and myeloproliferative neoplasms. Biology of Blood and Marrow Transplantation , 20(6), 837–843.
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A Reduced-Toxicity Regimen Is Associated with Durable Engraftment and Clinical Cure of Nonmalignant Genetic Diseases among Children Undergoing Blood and Marrow Transplantation with an HLA-Matched Related Donor.
Mahadeo, K. M., Weinberg, K. I., Abdel-Azim, H., Miklos, D. B., Killen, R., Kohn, D., … Kapoor, N. (2015). A Reduced-Toxicity Regimen Is Associated with Durable Engraftment and Clinical Cure of Nonmalignant Genetic Diseases among Children Undergoing Blood and Marrow Transplantation with an HLA-Matched Related Donor. Biology of Blood and Marrow Transplantation , 21(3), 440–444.
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Therapeutic benefits targeting B-cells in chronic graft-versus-host disease
Nakasone, H., Sahaf, B., & Miklos, D. B. (2015). Therapeutic benefits targeting B-cells in chronic graft-versus-host disease. INTERNATIONAL JOURNAL OF HEMATOLOGY, 101(5), 438–451.
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Red blood cell transfusions are associated with HLA class I but not H-Y alloantibodies in children with sickle cell disease.
Nickel, R. S., Hendrickson, J. E., Yee, M. M., Bray, R. A., Gebel, H. M., Kean, L. S., … Horan, J. T. (2015). Red blood cell transfusions are associated with HLA class I but not H-Y alloantibodies in children with sickle cell disease. British Journal of Haematology, 170(2), 247–256.
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High-throughput allogeneic antibody detection using protein microarrays
Paul, J., Sahaf, B., Perloff, S., Schoenrock, K., Wu, F., Nakasone, H., … Miklos, D. (2016). High-throughput allogeneic antibody detection using protein microarrays. JOURNAL OF IMMUNOLOGICAL METHODS, 432, 57–64.
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Allogeneic T cells impair engraftment and hematopoiesis after stem cell transplantation
Mueller, A. M. S., Linderman, J. A., Florek, M., Miklos, D., & Shizuru, J. A. (2010). Allogeneic T cells impair engraftment and hematopoiesis after stem cell transplantation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(33), 14721–14726.
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The Biology of Chronic Graft-Versus-Host Disease: a Task Force Report From the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease.
Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., … Blazar, B. R. (2016). The Biology of Chronic Graft-Versus-Host Disease: a Task Force Report From the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease. Biology of Blood and Marrow Transplantation .
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Patient Comments
Patients comments are gathered from our Patient Satisfaction Survey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
SHC Patient, Apr 2018
All are friendly.
SHC Patient, Apr 2018
Dr. Miklos has the best bedside manor. He makes us feel so special.
SHC Patient, Apr 2018
All good & excellent. Excellent dr.
SHC Patient, Oct 2017
Dr. Miklos is outstanding. I feel confident I am getting to best (latest) care available.
SHC Patient, Aug 2017
Very professional.
SHC Patient, Jul 2017
An amazing doctor, totally feel taken care of, when under his care.
SHC Patient, May 2017
Dr. Miklos is exceptional.
SHC Patient, Feb 2017
Dr. Miklos good job he cares so much about his treatment for you and how you are doing.
SHC Patient, Feb 2017
The doctor spent a lot of time with us explaining my care, his team also spent a lot of time with us explaining treatment.
SHC Patient, Jan 2017
I fully trust Dr. Miklos with all my medical concerns. He's very caring & welcomed me & my family well. His nursing assistant is also great! Her name is Sandy Burgess & she always took care of all my concerns.
SHC Patient, Dec 2016
Dr. Miklos is very knowledgable & empathetic. Always available & responsive.
SHC Patient, Dec 2016
Huge fan of Dr Miklos!
SHC Patient, Dec 2016
Dr. Mikios is a wonderful doctor and a kind man.
SHC Patient, Sep 2016
Excellent.
SHC Patient, Aug 2016
Dr. Miklos is a star doctor. He genuinely cares about me and spends generous amount of time with me and my family. I got educated on my illness and I am very thankful to Dr. Miklos and his team.
SHC Patient, Aug 2016
Miklos provided a thorough amount of hand written info - But I was overwhelmed by the depth and technical aspects of what he described.
SHC Patient, May 2016
Dr. Miklos is the best! I feel very grateful to have him as my doctor!
SHC Patient, May 2016
Dr. Mikios is my hero. I thank him for taking me through the transplant and the following care.
SHC Patient, Nov 2015
I have just recently recommended Dr. Miklos.
SHC Patient, Aug 2015
They were great. Spoke clearly and spoke my language. They even made a visual to clarify it.
SHC Patient, May 2015
Dr. Miklos spent a lot of time with me and answered all my questions.
SHC Patient, May 2015
Dr. Miklos & the entire team was amazing the total care I received was truly wonderful.
SHC Patient, May 2015
Amazing care provided by Dr. Miklos. Lots of good information.
SHC Patient, Apr 2015
Dr. Miklos is wonderful, approachable and thorough.
SHC Patient, Mar 2015
One time I had a concern which really scared me when the dr. just say it is what it is and I felt like I'm just a number in a study and I just wondered how serious my illness (life) is in this study or if I'm just a number.
SHC Patient, Feb 2015
Dr. Miklos is amazing.
SHC Patient, Oct 2014
Good.
SHC Patient, Sep 2014
Dr. Miklos always answers any questions I have and has always given me the best care.
SHC Patient, Apr 2014
Dr. Miklos from thy 1st time I met him to my last visit I could have a more understanding, knowledgeable doctor ever. He is outstanding.
SHC Patient, Mar 2014
Dr. Miklos saved my life. Because of him I get to watch my daughter grow.
SHC Patient, Apr 2018
All are friendly.
SHC Patient, Apr 2018
Dr. Miklos has the best bedside manor. He makes us feel so special.
SHC Patient, Apr 2018
All good & excellent. Excellent dr.
SHC Patient, Oct 2017
Dr. Miklos is outstanding. I feel confident I am getting to best (latest) care available.
SHC Patient, Aug 2017
Very professional.
SHC Patient, Jul 2017
An amazing doctor, totally feel taken care of, when under his care.
SHC Patient, May 2017
Dr. Miklos is exceptional.
SHC Patient, Feb 2017
Dr. Miklos good job he cares so much about his treatment for you and how you are doing.
SHC Patient, Feb 2017
The doctor spent a lot of time with us explaining my care, his team also spent a lot of time with us explaining treatment.
SHC Patient, Jan 2017
I fully trust Dr. Miklos with all my medical concerns. He's very caring & welcomed me & my family well. His nursing assistant is also great! Her name is Sandy Burgess & she always took care of all my concerns.
SHC Patient, Dec 2016
Dr. Miklos is very knowledgable & empathetic. Always available & responsive.
SHC Patient, Dec 2016
Huge fan of Dr Miklos!
View All 30 Patient Comments »