David Miklos, M.D., Ph.D.

BMT specialist, Hematologist, Medical oncologist, Blood and marrow transplant specialist

Bio:   I am a physician-scientist who has established a human translational research group that fosters the development of both laboratory immunologists, and clinical translational researchers. Allogeneic hematopoietic cell transplantation (alloHCT) cures blood cancer via beneficial graft-v-tumor immunity. Our overall research goal is to augment GVT while preventing dertimental graft versus host disease (GVHD). The Miklos lab pioneered protein microarray technologies to disciiver clinically relevant allogeneic antibodies, especially those targeting H-Y antigens following sex mismatched transplantation. Our discovery that allogeneic HY antibodies develop in association with chronic GVHD revealed a critical B cell role in chronic GVHD pathogenesis and our clinical trials established cGVHD therapeutic benefits using anti-B cell drugs rituximab and ibrutinib. We developed high-throughput sequencing of the B and T cell immune receptor thereby enabling: 1) lymphoid disease quantification, 2) detailed B and T cell donor reconstitution kinetics, and 3) clonal analysis of antigen specific responses following allo-HCT.

Immunotherapy is revolutionizing cancer treatment and as the Stanford Clinical Cancer Cell Therapy program develops and evaluates the most promising cutting-edge cell therapies for cancer patients on a variety of clinical trials. Chimeric Antigen T Cell (CAR-T) therapy targets the patient's T lymphocytes to attack their cancer by infecting their own T cells to express chimeric antigen receptor (CAR) proteins that target and kill cancer cell expressing surface proteins. Thus far, the most successful CAR-T have targeted B cell antigen CD19, and ongoing trials are treating patients with relapsed/refractory Diffuse Large B Cell Lymphoma (DLBCL) using this CAR19 therapy.
4.9 out of 5
189 Patient Ratings
14 Patient Comments

Blood and Marrow Transplant Program (BMT)

  • 875 Blake Wilbur Drive
  • Clinic E, 1st Floor
  • Palo Alto, CA 94304
  • Phone: 650-723-0822
More Clinic Information » Insurance Coverage » Getting Here » Make An Appointment

Hematology Program

  • 875 Blake Wilbur Drive
  • Clinic C
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
More Clinic Information » Insurance Coverage » Getting Here » Make An Appointment

Cancer Immunotherapy Program

Professional Education

  • Fellowship: Dana Farber Cancer Institute Hematology Oncology Fellowship (2001) MA
  • Residency: Brigham and Women's Hospital Harvard Medical School (1998) MA
  • Internship: Brigham and Women's Hospital Harvard Medical School (1996) MA
  • Medical Education: Yale University (1995) CT
  • B.S., University of Notre Dame (1987)
  • M.D., Yale University Medical School (1995)
  • Ph.D., Yale University, Genetics (1995)

Honors & Awards

  • Phi Betta Kappa, University of Notre Dame (1987)
  • Alpha Omega Alpha, Yale Medical School (1995)
  • Predoctoral Fellow, Howard Hughes Medical Institute (1989-1993)
  • Medical Scientist Training Fellow, NIH (1993-1995)
  • Clinical Investigator Training Program Scholar, Harvard Medical School (2001-2003)

Administrative Appointments

  • Clinical Director Cancer Cell Therapy, Stanford University (2016 - Present)
  • Medical Director of Stanford Cellular Therapeutics and Transplantation Laboratory, Stanford University (2011 - Present)
  • Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease, NIH (2004 - Present)

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

4.9

Friendliness

4.9

Recommended to others

4.9

Explanations

4.9

Listens

4.9

Includes you in decisions

4.8

Clear Communication

4.9

Confidence in your doctor

3.9

Wait times

SHC Patient, May 2016

Dr. Miklos is the best! I feel very grateful to have him as my doctor!

SHC Patient, May 2016

Dr. Mikios is my hero. I thank him for taking me through the transplant and the following care.

SHC Patient, Nov 2015

I have just recently recommended Dr. Miklos.

SHC Patient, Aug 2015

They were great. Spoke clearly and spoke my language. They even made a visual to clarify it.

SHC Patient, May 2015

Dr. Miklos spent a lot of time with me and answered all my questions.

SHC Patient, May 2015

Dr. Miklos & the entire team was amazing the total care I received was truly wonderful.

SHC Patient, May 2015

Amazing care provided by Dr. Miklos. Lots of good information.

SHC Patient, Apr 2015

Dr. Miklos is wonderful, approachable and thorough.

SHC Patient, Mar 2015

One time I had a concern which really scared me when the dr. just say it is what it is and I felt like I'm just a number in a study and I just wondered how serious my illness (life) is in this study or if I'm just a number.

SHC Patient, Feb 2015

Dr. Miklos is amazing.

SHC Patient, Oct 2014

Good.

SHC Patient, Sep 2014

Dr. Miklos always answers any questions I have and has always given me the best care.

View All 14 Patient Comments »
4.9 out of 5
189 Patient Ratings
14 Patient Comments

SHC Patient, May 2016

Dr. Miklos is the best! I feel very grateful to have him as my doctor!

SHC Patient, May 2016

Dr. Mikios is my hero. I thank him for taking me through the transplant and the following care.

SHC Patient, Nov 2015

I have just recently recommended Dr. Miklos.

SHC Patient, Aug 2015

They were great. Spoke clearly and spoke my language. They even made a visual to clarify it.

SHC Patient, May 2015

Dr. Miklos spent a lot of time with me and answered all my questions.

SHC Patient, May 2015

Dr. Miklos & the entire team was amazing the total care I received was truly wonderful.

SHC Patient, May 2015

Amazing care provided by Dr. Miklos. Lots of good information.

SHC Patient, Apr 2015

Dr. Miklos is wonderful, approachable and thorough.

SHC Patient, Mar 2015

One time I had a concern which really scared me when the dr. just say it is what it is and I felt like I'm just a number in a study and I just wondered how serious my illness (life) is in this study or if I'm just a number.

SHC Patient, Feb 2015

Dr. Miklos is amazing.

SHC Patient, Oct 2014

Good.

SHC Patient, Sep 2014

Dr. Miklos always answers any questions I have and has always given me the best care.

SHC Patient, Apr 2014

Dr. Miklos from thy 1st time I met him to my last visit I could have a more understanding, knowledgeable doctor ever. He is outstanding.

SHC Patient, Mar 2014

Dr. Miklos saved my life. Because of him I get to watch my daughter grow.