Biography


I am the Chief of Stanford BMT and Cell Therapy Program providing 600 cancer cell therapies annually. Our BMT-CT research group fosters the development of both laboratory immunologists, and clinical translational researchers. Our Allogeneic hematopoietic cell transplantation (alloHCT) research is optimizing graft content of CD34 HSC, conventional T lymphocyte, and regulatory T cell content in order to cures blood cancers via beneficial graft-v-tumor (GVT) immunity. Our overall research goal is to augment GVT while preventing detrimental graft versus host disease (GVHD). Our CAR-T research provide the most direct targeting of cancer and has dramatically helped patients with leukemia and Lymphoma already.

The Miklos lab pioneered protein microarray technologies to discover clinically relevant allogeneic antibodies, especially those targeting H-Y antigens following sex mismatched transplantation. Our discovery that allogeneic HY antibodies develop in association with chronic GVHD revealed a critical B cell role in chronic GVHD pathogenesis and our clinical trials established cGVHD therapeutic benefits using anti-B cell drugs rituximab and ibrutinib. We developed high-throughput sequencing of the B and T cell immune receptor thereby enabling: 1) lymphoid disease quantification, 2) detailed B and T cell donor reconstitution kinetics, and 3) clonal analysis of antigen specific responses following allo-HCT.

Immunotherapy is revolutionizing cancer treatment and Stanford Cancer Cell Therapy Program is developing and evaluating the most promising chimeric antigen T-cell (CAR-T) therapies. CAR-T genetically modifies the patient's T lymphocytes to target their cancer. Thus far, the most successful CAR-T have targeted B cell antigens CD19, CD20, CD22, and BCMA, and our ongoing trials are treating patients with relapsed/refractory leukemia, lymphoma, and multiple myeloma.

Professional Summary


Professional Education
  • Board Certification: American Board of Internal Medicine, Hematology (2002)
  • Board Certification, American Board of Internal Medicine, Hematology (2019)
  • Medical Education: Yale University Office of the Registrar (1995) CT
  • Fellowship: Dana Farber Cancer Institute Hematology Oncology Fellowship (2001) MA
  • Residency: Brigham and Women's Hospital Harvard Medical School (1998) MA
  • Internship: Brigham and Women's Hospital Harvard Medical School (1996) MA
  • B.S., University of Notre Dame (1987)
  • M.D., Yale University Medical School (1995)
  • Ph.D., Yale University, Genetics (1995)

Honors & Awards
  • Alpha Omega Alpha, Yale Medical School (1995)
  • Clinical Investigator Training Program Scholar, Harvard Medical School (2001-2003)
  • Medical Scientist Training Fellow, NIH (1993-1995)
  • Phi Betta Kappa, University of Notre Dame (1987)
  • Predoctoral Fellow, Howard Hughes Medical Institute (1989-1993)

Administrative Appointments
  • Associate Chief Blood and Marrow Transplantation, Stanford University (2020 - 2021)
  • Clinical Director Cancer Cell Therapy, Stanford University (2016 - Present)
  • Medical Director of Stanford Cellular Therapeutics and Transplantation Laboratory, Stanford University (2011 - 2016)

Publications

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.


Practice Locations


Blood and Marrow Transplant Program (BMT) - 900 Blake Wilbur Drive Palo Alto, CA
Palo Alto, CA

900 Blake Wilbur Drive, 2nd Floor

Palo Alto , CA 94304

(650) 498-6000

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Patient Ratings

(70 Ratings)

Overall Rating
4.8/5

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4.8/5
Friendliness
Friendliness/courtesy of the care provider
4.8/5
Explanations
Explanations the care provider gave you about your problem or condition
4.8/5
Listens
Concern the care provider showed for your questions or worries
4.8/5
Care provider's efforts to include you in decisions about your care
Care provider's efforts to include you in decisions about your care
4.6/5
Clear Communication
Degree to which care provider talked with you using words you could understand
4.7/5
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4.8/5
Recommend to others
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3.8/5
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How Our Ratings Work

The Patients Ratings and comments are gathered from our Patient Satisfaction Survey and displayed in their entirety.

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Patient Reviews

(46 reviews)

Dr. Miklos & Janette Kimes were wonderful to have on "my" team. EXCELLENT!
5+ years of care very honored to call David my dr.
We felt that the whole process and decision for treatment was thoroughly explained using imaging and diagrams.
Dr. Miklos spent time explaining & answering my questions. Did not feel rushed, Dr. Miklos took time to explain... excellent!!!
Dr. Miklos was great! Could not yell it louder if I was Tony the Tiger.
Dr. Miklos and team are AMAZING.
I have told everyone who will listen about the excellent care, concern, and warmth of the staff at Stanford.
An excellent experience! This was a visit to discuss treatments for serious disease. Dr. Miklos seems like an excellent clinician AND a researcher. It was like having an oncologist in the family!
Dr. Miklos and his physician assistant always gave me the best care possible.
Good because they provided very good time.
Dr. Miklos is the best. I am alive because of him and the treatment at Stanford.
The doctors & support staff were very supportive and positive to addressing my problem (cancer) and my recovery.
I was very impressed.
Since this was a trial, the staff was very open & honest regarding expected results.
The staff's care of my treatment was very good, especially their positive attitude for my recovery.
Dr. Miklos and his fellow, Jay Spiegal, are extremely knowledgeable, regarding my situation - answer all questions so that I could understand and are always caring and helpful.
All are friendly.
Dr. Miklos has the best bedside manor. He makes us feel so special.
All good & excellent. Excellent dr.
Dr. Miklos is outstanding. I feel confident I am getting to best (latest) care available.
Very professional.
An amazing doctor, totally feel taken care of, when under his care.
Dr. Miklos is exceptional.
Dr. Miklos good job he cares so much about his treatment for you and how you are doing.
The doctor spent a lot of time with us explaining my care, his team also spent a lot of time with us explaining treatment.
I fully trust Dr. Miklos with all my medical concerns. He's very caring & welcomed me & my family well. His nursing assistant is also great! Her name is Sandy Burgess & she always took care of all my concerns.
Dr. Miklos is very knowledgable & empathetic. Always available & responsive.
Huge fan of Dr Miklos!
Dr. Mikios is a wonderful doctor and a kind man.
Excellent.
Dr. Miklos is a star doctor. He genuinely cares about me and spends generous amount of time with me and my family. I got educated on my illness and I am very thankful to Dr. Miklos and his team.
Miklos provided a thorough amount of hand written info - But I was overwhelmed by the depth and technical aspects of what he described.
Dr. Miklos is the best! I feel very grateful to have him as my doctor!
Dr. Mikios is my hero. I thank him for taking me through the transplant and the following care.
I have just recently recommended Dr. Miklos.
They were great. Spoke clearly and spoke my language. They even made a visual to clarify it.
Dr. Miklos spent a lot of time with me and answered all my questions.
Dr. Miklos & the entire team was amazing the total care I received was truly wonderful.
Amazing care provided by Dr. Miklos. Lots of good information.
Dr. Miklos is wonderful, approachable and thorough.
One time I had a concern which really scared me when the dr. just say it is what it is and I felt like I'm just a number in a study and I just wondered how serious my illness (life) is in this study or if I'm just a number.
Dr. Miklos is amazing.
Good.
Dr. Miklos always answers any questions I have and has always given me the best care.
Dr. Miklos from thy 1st time I met him to my last visit I could have a more understanding, knowledgeable doctor ever. He is outstanding.
Dr. Miklos saved my life. Because of him I get to watch my daughter grow.

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