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Joy Wu, MD, PhD
Endocrinologist
Assistant Professor of Medicine (Endocrinology)
Bio:
Dr. Joy Wu is a board-certified endocrinologist with over 12 years' experience who specializes in treating women and men with osteoporosis and other bone and mineral diseases, including primary hyperparathyroidism, vitamin D deficiency, Paget's disease and fibrous dysplasia. She has a special interest in optimizing skeletal health for those at risk of bone loss from glucocorticoid treatment, cancer therapies, or organ transplant. She works closely with each individual and his/her referring physician to assess fracture risk, and to develop a tailored treatment and monitoring plan.
Dr. Wu directs a broad basic and translational research program that focuses on skeletal development and the bone marrow hematopoietic niche. Her laboratory is currently studying stem cell therapies for bone formation, and the prevention of cancer metastases to bone (joywulab.stanford.edu). She has been honored with awards from the NIH Director’s New Innovator Award, the Endocrine Society, the American Society for Bone and Mineral Research, and the Mary Kay Foundation. Dr. Wu is committed to training the next generation of physician scientists, and serves as Co-Director of the Stanford Internal Medicine Translational Investigator Program.
Dr. Wu directs a broad basic and translational research program that focuses on skeletal development and the bone marrow hematopoietic niche. Her laboratory is currently studying stem cell therapies for bone formation, and the prevention of cancer metastases to bone (joywulab.stanford.edu). She has been honored with awards from the NIH Director’s New Innovator Award, the Endocrine Society, the American Society for Bone and Mineral Research, and the Mary Kay Foundation. Dr. Wu is committed to training the next generation of physician scientists, and serves as Co-Director of the Stanford Internal Medicine Translational Investigator Program.
- 300 Pasteur Drive
- 1st Floor, Suite A175
- Stanford , CA 94305
- Phone: 650-721-1300
- 300 Pasteur Drive
- 1st Floor, Suite A175
- Stanford , CA 94305
- Phone: 650-721-1300
Practice Areas
Professional Education
- Board Certification: Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine (2006)
- Fellowship: Massachusetts General Hospital (2006) MA
- Residency: Brigham and Women's Hospital Harvard Medical School (2003) MA
- Medical Education: Duke University School of Medicine (2001) NC
- MD/PhD, Duke University (2001)
Honors & Awards
- Alpha Omega Alpha, Duke University School of Medicine (1997)
- Cancer Grant Recipient, The Mary Kay Foundation (2013)
- Claflin Distinguished Scholar Award, Massachusetts General Hospital (2009)
- Clinical Scientist Program Instructor Development Award, Harvard Stem Cell Institute (2009)
- Endocrine Scholars Award, The Endocrine Society (2006)
- John Haddad Young Investigator Award, Advances in Mineral Metabolism (2008)
- Marsden Memorial Award in Chemistry, Stanford University (1993)
- Merck Senior Fellow Award, The Endocrine Society (2007)
- NIH Director's New Innovator Award, NIH (2011)
- Phi Beta Kappa, Stanford University (1993)
- Young Investigator Award, American Society for Bone and Mineral Research Annual Meeting (2006)
Administrative Appointments
- Co-Director, Translational Investigator Program, Department of Medicine (2015 - Present)
Publications
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Ca2+/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix
Wu, J. Y., & Means, A. R. (2000). Ca2+/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(11), 7994–7999. -
Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4
Wu, J. Y., Ribar, T. J., Cummings, D. E., Burton, K. A., McKnight, G. S., & Means, A. R. (2000). Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. NATURE GENETICS, 25(4), 448–452. -
Female fertility is reduced in mice lacking Ca2+ calmodulin-dependent protein kinase IV
Wu, J. Y., Gonzalez-Robayna, I. J., Richards, J. S., & Means, A. R. (2000). Female fertility is reduced in mice lacking Ca2+ calmodulin-dependent protein kinase IV. ENDOCRINOLOGY, 141(12), 4777–4783. -
Spermatogenesis and the regulation of Ca2+-calmodulin-dependent protein kinase IV localization are not dependent on calspermin
Wu, J. Y., Ribar, T. J., & Means, A. R. (2001). Spermatogenesis and the regulation of Ca2+-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. MOLECULAR AND CELLULAR BIOLOGY, 21(17), 6066–6070.
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Osteoblastic regulation of B lymphopoiesis is mediated by G(s)alpha-dependent signaling pathways
Wu, J. Y., Purton, L. E., Rodda, S. J., Chen, M., Weinstein, L. S., McMahon, A. P., … Kronenberg, H. M. (2008). Osteoblastic regulation of B lymphopoiesis is mediated by G(s)alpha-dependent signaling pathways. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(44), 16976–16981.
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Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches
Wu, J. Y., Scadden, D. T., & Kronenberg, H. M. (2009). Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches. JOURNAL OF BONE AND MINERAL RESEARCH, 24(5), 759–764.
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Potent constitutive cyclic AMP-generating activity of XL alpha s implicates this imprinted GNAS product in the pathogenesis of McCune-Albright Syndrome and fibrous dysplasia of bone
Mariot, V., Wu, J. Y., Aydin, C., Mantovani, G., Mahon, M. J., Linglart, A., & Bastepe, M. (2011). Potent constitutive cyclic AMP-generating activity of XL alpha s implicates this imprinted GNAS product in the pathogenesis of McCune-Albright Syndrome and fibrous dysplasia of bone. BONE, 48(2), 312–320.
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G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
Wu, J. Y., Aarnisalo, P., Bastepe, M., Sinha, P., Fulzele, K., Selig, M. K., … Kronenberg, H. M. (2011). G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3492–3504.
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Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling.
Fulzele, K., Krause, D. S., Panaroni, C., Saini, V., Barry, K. J., Liu, X., … Divieti Pajevic, P. (2013). Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Blood, 121(6), 930–939.
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Interactions between B lymphocytes and the osteoblast lineage in bone marrow.
Panaroni, C., & Wu, J. Y. (2013). Interactions between B lymphocytes and the osteoblast lineage in bone marrow. Calcified Tissue International, 93(3), 261–268.
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Differential regulation of myeloid leukemias by the bone marrow microenvironment.
Krause, D. S., Fulzele, K., Catic, A., Sun, C. C., Dombkowski, D., Hurley, M. P., … Scadden, D. T. (2013). Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine, 19(11), 1513–1517.
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Teriparatide ( PTH1-34) Treatment Increases Peripheral Hematopoietic Stem Cells in Postmenopausal Women
Yu, E. W., Kumbhani, R., Siwila-Sackman, E., DeLelys, M., Preffer, F. I., Leder, B. Z., & Wu, J. Y. (2014). Teriparatide ( PTH1-34) Treatment Increases Peripheral Hematopoietic Stem Cells in Postmenopausal Women. JOURNAL OF BONE AND MINERAL RESEARCH, 29(6), 1380–1386.
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Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches.
Panaroni, C., Tzeng, Y.-S., Saeed, H., & Wu, J. Y. (2014). Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches. Current Osteoporosis Reports, 12(1), 22–32.
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The PTH-G alpha(s)-Protein Kinase A Cascade Controls alpha NAC Localization To Regulate Bone Mass
Pellicelli, M., Miller, J. A., Arabian, A., Gauthier, C., Akhouayri, O., Wu, J. Y., … St-Arnaud, R. (2014). The PTH-G alpha(s)-Protein Kinase A Cascade Controls alpha NAC Localization To Regulate Bone Mass. MOLECULAR AND CELLULAR BIOLOGY, 34(9), 1622–1633.
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Development of the skeleton
Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2013). Development of the skeleton. Osteoporosis, 4th Edition (pp. 97–126). Academic Press.
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The role of bone cells in establishing the hematopoietic stem cell niche
Wu, J. Y., & Kronenberg, H. M. (2011). The role of bone cells in establishing the hematopoietic stem cell niche. Osteoimmunology: Interactions of the Immune and Skeletal Systems (pp. 81–99).
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Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.
Tan, S. H., Senarath-Yapa, K., Chung, M. T., Longaker, M. T., Wu, J. Y., & Nusse, R. (2014). Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5262–71.
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Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis.
Yuan, K., Orcholski, M. E., Panaroni, C., Shuffle, E. M., Huang, N. F., Jiang, X., … de Jesus Perez, V. A. (2015). Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. American Journal of Pathology, 185(1), 69–84.
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Loss of G(s)alpha Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors
Sinha, P., Aarnisalo, P., Chubb, R., Ono, N., Fulzele, K., Selig, M., … Wu, J. Y. (2014). Loss of G(s)alpha Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors. JOURNAL OF BONE AND MINERAL RESEARCH, 29(11), 2414–2426.
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Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. (2015). The Journal of Experimental Medicine.
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PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.
Panaroni, C., Fulzele, K., Saini, V., Chubb, R., Pajevic, P. D., & Wu, J. Y. (2015). PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. Journal of Bone and Mineral Research , 30(12), 2273–2286.
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RAR gamma is a negative regulator of osteoclastogenesis
Green, A. C., Poulton, I. J., Vrahnas, C., Haeusler, K. D., Walkley, C. R., Wu, J. Y., … Purton, L. E. (2015). RAR gamma is a negative regulator of osteoclastogenesis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 150, 46–53.
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Pluripotent Stem Cells and Skeletal Regeneration-Promise and Potential
Wu, J. Y. (2015). Pluripotent Stem Cells and Skeletal Regeneration-Promise and Potential. CURRENT OSTEOPOROSIS REPORTS, 13(5), 342–350.
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Loss of Gsa in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.
Sinha, P., Aarnisalo, P., Chubb, R., Poulton, I. J., Guo, J., Nachtrab, G., … Wu, J. Y. (2016). Loss of Gsa in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy. Journal of Biological Chemistry, 291(4), 1631–1642.
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Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study
Valenzuela, A., Baron, M., Herrick, A. L., Proudman, S., Stevens, W., Rodriguez-Reyna, T. S., … Chung, L. (2016). Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study. SEMINARS IN ARTHRITIS AND RHEUMATISM, 46(3), 344–349.
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Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the, bone marrow
Johnson, R. W., Fingers, E. C., Olcina, M. M., Vilalta, M., Aguilera, T., Miao, Y., … Giaccia, A. J. (2016). Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the, bone marrow. NATURE CELL BIOLOGY, 18(10), 1078–89.
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Bone Density Loss Is Associated With Blood Cell Counts.
Valderrábano, R. J., Lui, L.-Y., Lee, J., Cummings, S. R., Orwoll, E. S., Hoffman, A. R., & Wu, J. Y. (2016). Bone Density Loss Is Associated With Blood Cell Counts. Journal of Bone and Mineral Research .
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SIKs control osteocyte responses to parathyroid hormone
Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., … Kronenberg, H. M. (2016). SIKs control osteocyte responses to parathyroid hormone. NATURE COMMUNICATIONS, 7.
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Evidence for use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients.
Chaudhary, N., Lee, J. S., Wu, J. Y., & Tharin, S. (2016). Evidence for use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients. World Neurosurgery.
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Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.
Fan, Y., Hanai, J.-ichi, Le, P. T., Bi, R., Maridas, D., DeMambro, V., … Lanske, B. (2017). Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metabolism.
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Older Men with Anemia Have Increased Fracture Risk Independent of Bone Mineral Density.
Valderrábano, R. J., Lee, J., Lui, L.-Y., Hoffman, A. R., Cummings, S. R., Orwoll, E. S., & Wu, J. Y. (2017). Older Men with Anemia Have Increased Fracture Risk Independent of Bone Mineral Density. Journal of Clinical Endocrinology and Metabolism.
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Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
Pierini, A., Nishikii, H., Baker, J., Kimura, T., Kwon, H.-S., Pan, Y., … Negrin, R. S. (2017). Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. NATURE COMMUNICATIONS, 8.
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Gs alpha Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and beta-Catenin Pathways
Ramaswamy, G., Kim, H., Zhang, D., Lounev, V., Wu, J. Y., Choi, Y., … Shore, E. M. (2017). Gs alpha Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and beta-Catenin Pathways. SCIENTIFIC REPORTS, 7.
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Development of the Skeleton
Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2008). Development of the Skeleton. Osteoporosis, 3rd Edition (pp. 241–269). Academic Press.
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Bone marrow hematopoietic niches
Wu, J. Y., & Kronenberg, H. M. (2016). Bone marrow hematopoietic niches. Osteoimmunology: Interactions of the Immune and Skeletal Systems, 2nd Edition (pp. 103–119). Academic Press.
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Pharmacology
Wu, J. Y. (1999). Pharmacology. Crashing the boards: a user friendly study guide for the USMLE step 1 (pp. 31–47). Lippincott Williams and Wilkins.
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Clarifying the contributions of distinct mesenchymal populations in supporting hematopoiesis [editorial]
Wu, J. Y. (2010). Clarifying the contributions of distinct mesenchymal populations in supporting hematopoiesis [editorial]. IBMS BoneKEy , 7.
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In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments.
Chubb, R., Oh, J., Riley, A. K., Kimura, T., Wu, S. M., & Wu, J. Y. (2017). In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments. Stem Cells (Dayton, Ohio).
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Patient Comments
Patients comments are gathered from our Patient Satisfaction Survey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
SHC Patient, Jul 2017
Doctor Wu was wonderful - explained very thoroughly - where I was able to understand. Very warm.
SHC Patient, Jun 2017
So glad I came!! So grateful I got a second opinion!!
SHC Patient, May 2017
Re: words I could understand - Dr. Wu used alternative words when I showed I did not understand. She is great.
SHC Patient, May 2017
This consultation with Dr. Wu was very helpful in helping me weigh all the pros & cons of taking Prolia I had lots of questions and she took the time to give me very detailed and personalized explanations taking into account my own physical condition. Very helpful!
SHC Patient, Apr 2017
Dr. Wu is exceptionally knowledgeable and devoted the time needed to go over the plan and to answer all of my questions in detail.
SHC Patient, Mar 2017
Dr. Wu is awesome!
SHC Patient, Jan 2017
Dr. Wu is a very very good doctor. I would recommend her to anybody who needs the care! Thank you! Dr. Wu, you are the best!!!
SHC Patient, Jan 2017
Dr. Joy Wu is the best doctor/specialist I have ever worked with, and I have very high confidence in my treatment by her.
SHC Patient, Jan 2017
Dr. Wu is by far the BEST DOCTOR I've EVER had. She listens & completely included me in her decisions. She took my specific needs into account & discussed w/me her plan & reasoning. Absolutely awesome!!
SHC Patient, Dec 2016
I really liked Dr. Wu, she spent a lot of time with me - explained test results & implications for short & long term future. She was empathetic & thorough.
SHC Patient, Dec 2016
Dr. Wu is great & I loved how she walked me through a mathematical analysis of my risk factors.
SHC Patient, Oct 2016
Dr. Joy Wu is an exceptional physician. Truly concerned for my welfare. Includes me in all discussions and plan of care. Takes care of me as a total person -> physical, mental, emotional. She is the best and a great researcher!
SHC Patient, Sep 2016
Can't say enough good things about care provider. Please thank Dr. Wu.
SHC Patient, Sep 2016
I was favorably impressed with Dr. Joy Wu & knowledge of my condition and confident of her recommendations.
SHC Patient, Sep 2016
Excellent experience.
SHC Patient, Aug 2016
Dr. Wu is outstanding...quite simply the best endocrinologist I've consulted ever.
SHC Patient, Jul 2016
Dr. Wu was wonderful - professional and friendly.
SHC Patient, Jun 2016
Very good experience with Dr. Wu and all others in the clinic.
SHC Patient, May 2016
Excellent doctor.
SHC Patient, May 2016
My experience with Dr. Joy Wu continues to be excellent. She is genuinely concerned for me as her patient - my well being and includes me in her plan of care! After giving her professional best recommendation, the time plan is decided by MD and patient together. She is exceptional.
SHC Patient, May 2016
Very good experience, thanks very much, Dr. Wu!
SHC Patient, Mar 2016
Dr. Wu is excellent!!
SHC Patient, Mar 2016
Dr. Wu was very easy to talk to. She discussed my condition and the plan to treat thoroughly and made sure all of my questions were answered.
SHC Patient, Jan 2016
Dr. Wu is a very patient - friendly MD. Every MD and be like her. She read my medical history before she came to the room so she knew what I went through for the year avoiding what every MD asks you .... what brings you here?
SHC Patient, Dec 2015
The minute I talked w/her, I already knew she is my doctor who will see me w/my problem. Very thorough, kind, understanding and she explained everything in my level of understanding.
SHC Patient, Dec 2015
The majority of time was spent with a resident dr. Dr. Wu came in at the end for the final consultation - I would rate her excellent in all categories. I have great confidence in her.
SHC Patient, Nov 2015
Thank you Dr. Wu - Really nice & explained everything clearly.
SHC Patient, Nov 2015
Excellent care; Dr. Wu listened and understood my concerns about the medication. I was treated with respect. Excellent doctor and best of all I can TRUST her judgment & advice.
SHC Patient, Sep 2015
Dr. Wu is a very good, caring, professional. She answers my questions very clear and very helpful. She is a wonderful doctor. I am glad she is my doctor.
SHC Patient, Aug 2015
She took the time to answer all of my copious notes, and questions.
SHC Patient, Aug 2015
Dr. Wu is extremely busy did not have enough time to spend with patient.
SHC Patient, May 2015
Dr. Wu is probably one of the very best doctors I have ever seen! She was knowledgeable, caring, kind & excellent!! I was very impressed & feel very fortunate to have been able to have her as my doctor!
SHC Patient, Apr 2015
The medical staff (MD's) were excellent.
SHC Patient, Feb 2015
Good.
SHC Patient, Jan 2015
No options except for one medication were recommended. I asked about an additional measures I could take to address my problem (PT, diet, vitamin supplements) and was told I was already day everything possible. Doctor was not willing to explain other options.
SHC Patient, May 2014
Dr. Wu was wonderful! I couldn't have asked for a better exp.
SHC Patient, Jul 2017
Doctor Wu was wonderful - explained very thoroughly - where I was able to understand. Very warm.
SHC Patient, Jun 2017
So glad I came!! So grateful I got a second opinion!!
SHC Patient, May 2017
Re: words I could understand - Dr. Wu used alternative words when I showed I did not understand. She is great.
SHC Patient, May 2017
This consultation with Dr. Wu was very helpful in helping me weigh all the pros & cons of taking Prolia I had lots of questions and she took the time to give me very detailed and personalized explanations taking into account my own physical condition. Very helpful!
SHC Patient, Apr 2017
Dr. Wu is exceptionally knowledgeable and devoted the time needed to go over the plan and to answer all of my questions in detail.
SHC Patient, Mar 2017
Dr. Wu is awesome!
SHC Patient, Jan 2017
Dr. Wu is a very very good doctor. I would recommend her to anybody who needs the care! Thank you! Dr. Wu, you are the best!!!
SHC Patient, Jan 2017
Dr. Joy Wu is the best doctor/specialist I have ever worked with, and I have very high confidence in my treatment by her.
SHC Patient, Jan 2017
Dr. Wu is by far the BEST DOCTOR I've EVER had. She listens & completely included me in her decisions. She took my specific needs into account & discussed w/me her plan & reasoning. Absolutely awesome!!
SHC Patient, Dec 2016
I really liked Dr. Wu, she spent a lot of time with me - explained test results & implications for short & long term future. She was empathetic & thorough.
SHC Patient, Dec 2016
Dr. Wu is great & I loved how she walked me through a mathematical analysis of my risk factors.
SHC Patient, Oct 2016
Dr. Joy Wu is an exceptional physician. Truly concerned for my welfare. Includes me in all discussions and plan of care. Takes care of me as a total person -> physical, mental, emotional. She is the best and a great researcher!
View All 36 Patient Comments »