Jeffrey S. Glenn, M.D., Ph.D.

Associate Professor of Medicine (Gastroenterology and Hepatology) and of Microbiology and Immunology

Professional Education

Fellowship: Stanford University School of Medicine (1999) CA

Residency: Stanford University School of Medicine (1995) CA

Internship: Stanford University School of Medicine (1994) CA

Medical Education: UCSF School of Medicine (1993) CA

Ph.D., U.C.S.F., Biochemistry and Biophysics (1992)

M.D., U.C.S.F., Medicine/MSTP (1993)

Honors & Awards

Summa cum laude, U.C. Berkeley (1984)

Physician Postdoctoral Fellowship Award, Howard Hughes Medical Institute (1995-1998)

Career Award, Burroughs Wellcome Fund (1998-2005)

Clinical Scientist Award in Translational Research, Burroughs Wellcome Fund (2005-2010)

Elected member, American Society for Clinical Investigation (2008)

Regents Scholarship, U.C.S.F. (1984-1993)

Translational Research Award, American Liver Foundation/Amgen/AASLD (1998-2002)

Administrative Appointments

Director, Center for Hepatitis and Liver Tissue Engineering (2006 - Present)

The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA
Lisowski, L., Elazar, M., Chu, K., Glenn, J. S., & Kay, M. A. (2013). The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA. NUCLEIC ACIDS RESEARCH, 41(6), 3688-3698.

Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction
Nishimura, T., Hu, Y., Wu, M., Pham, E., Suemizu, H., & Peltz, G. (2013). Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 344(2), 388-396.

Structural Map of a MicroRNA-122: Hepatitis C Virus Complex
Pang, P. S., Pham, E. A., Elazar, M., Patel, S. G., Eckart, M. R., & Glenn, J. S. (2012). Structural Map of a MicroRNA-122: Hepatitis C Virus Complex. JOURNAL OF VIROLOGY, 86(2), 1250-1254.

Simplified RNA secondary structure mapping by automation of SHAPE data analysis
Pang, P. S., Elazar, M., Pham, E. A., & Glenn, J. S. (2011). Simplified RNA secondary structure mapping by automation of SHAPE data analysis. NUCLEIC ACIDS RESEARCH, 39(22).

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
Thomas, C., Moraga, I., Levin, D., Krutzik, P. O., Podoplelova, Y., & Garcia, K. C. (2011). Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons. CELL, 146(4), 621-632.

The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein
Lee, C., Ma, H., Hang, J. Q., Leveque, V., Sklan, E. H., & Glenn, J. S. (2011). The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. VIROLOGY, 414(1), 10-18.

Role for ADP Ribosylation Factor 1 in the Regulation of Hepatitis C Virus Replication
Matto, M., Sklan, E. H., David, N., Melamed-Book, N., Casanova, J. E., & Aroeti, B. (2011). Role for ADP Ribosylation Factor 1 in the Regulation of Hepatitis C Virus Replication. JOURNAL OF VIROLOGY, 85(2), 946-956.

Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability
Lee, W., Cho, N.-J., Xiong, A., Glenn, J. S., & Frank, C. W. (2010). Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(48), 20709-20714.

The Future of HCV Therapy: NS4B as an Antiviral Target
Dvory-Sobol, H., Pang, P. S., & Glenn, J. S. (2010). The Future of HCV Therapy: NS4B as an Antiviral Target. VIRUSES-BASEL, 2(11), 2481-2492.

Prevalence, Correlates, and Viral Dynamics of Hepatitis Delta among Injection Drug Users
Kucirka, L. M., Farzadegan, H., Feld, J. J., Mehta, S. H., Winters, M., & Golub, E. T. (2010). Prevalence, Correlates, and Viral Dynamics of Hepatitis Delta among Injection Drug Users. JOURNAL OF INFECTIOUS DISEASES, 202(6), 845-852.

Transdifferentiation of adipose-derived stem cells into hepatocytes: a new approach
Lue, J., Lin, G., Ning, H., Xiong, A., Lin, C.-S., & Glenn, J. S. (2010). Transdifferentiation of adipose-derived stem cells into hepatocytes: a new approach. LIVER INTERNATIONAL, 30(6), 913-922.

A small molecule inhibits HCV replication and alters NS4B's subcellular distribution
Bryson, P. D., Cho, N.-J., Einav, S., Lee, C., Tai, V., & Glenn, J. S. (2010). A small molecule inhibits HCV replication and alters NS4B's subcellular distribution. ANTIVIRAL RESEARCH, 87(1), 1-8.

The Hepatitis C Virus (HCV) NS4B RNA Binding Inhibitor Clemizole Is Highly Synergistic with HCV Protease Inhibitors
Einav, S., Dvory-Sobol, H., Gehrig, E., & Glenn, J. S. (2010). The Hepatitis C Virus (HCV) NS4B RNA Binding Inhibitor Clemizole Is Highly Synergistic with HCV Protease Inhibitors. JOURNAL OF INFECTIOUS DISEASES, 202(1), 65-74.

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems
Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M. A., & Fire, A. Z. (2010). Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLOS PATHOGENS, 6(2).

Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B
Cho, N.-J., Dvory-Sobol, H., Lee, C., Cho, S.-J., Bryson, P., & Glenn, J. S. (2010). Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B. SCIENCE TRANSLATIONAL MEDICINE, 2(15).

Mixing the right hepatitis C inhibitor cocktail.
Gelman, M. A., & Glenn, J. S. (2010). Mixing the right hepatitis C inhibitor cocktail. Trends in molecular medicine.

Mechanism of an Amphipathic alpha-Helical Peptide's Antiviral Activity Involves Size-Dependent Virus Particle Lysis
Cho, N.-J., Dvory-Sobol, H., Xiong, A., Cho, S.-J., Frank, C. W., & Glenn, J. S. (2009). Mechanism of an Amphipathic alpha-Helical Peptide's Antiviral Activity Involves Size-Dependent Virus Particle Lysis. ACS CHEMICAL BIOLOGY, 4(12), 1061-1067.

The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types
Lee, W., Wiseman, M. E., Cho, N.-J., Glenn, J. S., & Frank, C. W. (2009). The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. BIOMATERIALS, 30(34), 6648-6654.

The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2 alpha Via Protein Kinase Activated by Double-Stranded RNA Activation
Elazar, M., Liu, M., Mckenna, S. A., Liu, P., Gehrig, E. A., & Glenn, J. S. (2009). The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2 alpha Via Protein Kinase Activated by Double-Stranded RNA Activation. GASTROENTEROLOGY, 137(5), 1827-1835.

The Effect of Donor Race on the Survival of Black Americans Undergoing Liver Transplantation for Chronic Hepatitis C
Pang, P. S., Kamal, A., & Glenn, J. S. (2009). The Effect of Donor Race on the Survival of Black Americans Undergoing Liver Transplantation for Chronic Hepatitis C. LIVER TRANSPLANTATION, 15(9), 1126-1132.

The Evolution of the Major Hepatitis C Genotypes Correlates with Clinical Response to Interferon Therapy
Pang, P. S., Planet, P. J., & Glenn, J. S. (2009). The Evolution of the Major Hepatitis C Genotypes Correlates with Clinical Response to Interferon Therapy. PLOS ONE, 4(8).

Alpha-Helical Peptide-Induced Vesicle Rupture Revealing New Insight into the Vesicle Fusion Process As Monitored in Situ by Quartz Crystal Microbalance-Dissipation and Reflectometry
Cho, N.-J., Wang, G., Edvardsson, M., Glenn, J. S., Hook, F., & Frank, C. W. (2009). Alpha-Helical Peptide-Induced Vesicle Rupture Revealing New Insight into the Vesicle Fusion Process As Monitored in Situ by Quartz Crystal Microbalance-Dissipation and Reflectometry. ANALYTICAL CHEMISTRY, 81(12), 4752-4761.

Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel
Cho, N.-J., Elazar, M., Xiong, A., Lee, W., Chiao, E., & Glenn, J. S. (2009). Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel. BIOMEDICAL MATERIALS, 4(1).

Potential for Hepatitis C Virus Resistance to Nitazoxanide or Tizoxanide
Korba, B. E., Elazar, M., Lui, P., Rossignol, J.-F., & Glenn, J. S. (2008). Potential for Hepatitis C Virus Resistance to Nitazoxanide or Tizoxanide. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 52(11), 4069-4071.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
Einav, S., Gerber, D., Bryson, P. D., Sklan, E. H., Elazar, M., & Quake, S. R. (2008). Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. NATURE BIOTECHNOLOGY, 26(9), 1019-1027.

Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells
Chiao, E., Elazar, M., Xing, Y., Xiong, A., Kmet, M., & Baker, J. (2008). Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells. STEM CELLS, 26(8), 2032-2041.

Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells
Xiong, A., Austin, T. W., Lagasse, E., Uchida, N., Tamaki, S., & Millan, M. T. (2008). Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells. TISSUE ENGINEERING PART A, 14(6), 995-1006.

The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection
Einav, S., Sklan, E. H., Moon, H. M., Gehrig, E., Liu, P., & Glenn, J. S. (2008). The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection. HEPATOLOGY, 47(3), 827-835.

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication
Sklan, E. H., Serrano, R. L., Einav, S., Pfeffer, S. R., Lambright, D. G., & Glenn, J. S. (2007). TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(50), 36354-36361.

Hepatitis d.
Koytak, E. S., Yurdaydin, C., & Glenn, J. S. (2007). Hepatitis d. Current treatment options in gastroenterology, 10(6), 456-463.

Creation of lipid partitions by deposition of amphipathic viral peptides
Cho, N.-J., Cho, S.-J., Hardesty, J. O., Glenn, J. S., & Frank, C. W. (2007). Creation of lipid partitions by deposition of amphipathic viral peptides. LANGMUIR, 23(21), 10855-10863.

A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication
Sklan, E. H., Staschke, K., Oakes, T. M., Elazar, M., Winters, M., & Glenn, J. S. (2007). A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. JOURNAL OF VIROLOGY, 81(20), 11096-11105.

Employing two different quartz crystal microbalance models to study changes in viscoelastic behavior upon transformation of lipid vesicles to a bilayer on a gold surface
Chot, N.-J., Kanazawa, K. K., Glenn, J. S., & Frank, C. W. (2007). Employing two different quartz crystal microbalance models to study changes in viscoelastic behavior upon transformation of lipid vesicles to a bilayer on a gold surface. ANALYTICAL CHEMISTRY, 79(18), 7027-7035.

Employing an amphipathic viral peptide to create a lipid bilayer on Au and TiO2
Cho, N.-J., Cho, S.-J., Cheong, K. H., Glenn, J. S., & Frank, C. W. (2007). Employing an amphipathic viral peptide to create a lipid bilayer on Au and TiO2. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(33), 10050-?.

Binding dynamics of hepatitis C virus' NS5A amphipathic peptide to cell and model membranes
Cho, N.-J., Cheong, K. H., Lee, C., Frank, C. W., & Glenn, J. S. (2007). Binding dynamics of hepatitis C virus' NS5A amphipathic peptide to cell and model membranes. JOURNAL OF VIROLOGY, 81(12), 6682-6689.

The power of silence: Application of small interfering RNAs to gastrointestinal diseases
Sklan, E. H., & Glenn, J. S. (2007). The power of silence: Application of small interfering RNAs to gastrointestinal diseases. GASTROENTEROLOGY, 132(7), 2291-2295.

Molecular virology of the hepatitis C virus: Implication for novel therapies
Glenn, J. S. (2006). Molecular virology of the hepatitis C virus: Implication for novel therapies. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 20(1), 81-?.

Prenylation of HDAg and antiviral drug development
Glenn, J. S. (2006). Prenylation of HDAg and antiviral drug development. HEPATITIS DELTA VIRUS, 307, 133-149.

Novel therapies for hepatitis C virus based on lessons from virology.
Glenn, J. S. (2005). Novel therapies for hepatitis C virus based on lessons from virology. Clinical gastroenterology and hepatology , 3(10), S86-8.

Molecular virology of the hepatitis C virus: implication for novel therapies.
Glenn, J. S. (2005). Molecular virology of the hepatitis C virus: implication for novel therapies. Clinics in liver disease, 9(3), 353-?.

Hepatitis C virus core protein associates with detergent-resistant membranes distinct from classical plasma membrane rafts
Matto, M., Rice, C. M., Aroeti, B., & Glenn, J. S. (2004). Hepatitis C virus core protein associates with detergent-resistant membranes distinct from classical plasma membrane rafts. JOURNAL OF VIROLOGY, 78(21), 12047-12053.

An n-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication
Elazar, M., Liu, P., Rice, C. M., & Glenn, J. S. (2004). An n-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication. JOURNAL OF VIROLOGY, 78(20), 11393-11400.

A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
Einav, S., Elazar, M., Danieli, T., & Glenn, J. S. (2004). A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. JOURNAL OF VIROLOGY, 78(20), 11288-11295.

Overdependence on the host-an Achilles' heel of HCV?
Glenn, J. S. (2004). Overdependence on the host-an Achilles' heel of HCV?. Hepatology , 39(6), 1734-1735.

Testing antivirals against hepatitis delta virus: farnesyl transferase inhibitors.
Bordier, B. B., & Glenn, J. S. (2004). Testing antivirals against hepatitis delta virus: farnesyl transferase inhibitors. Methods in molecular medicine, 96, 539-553.

Prenylation inhibitors: a novel class of antiviral agents
Einav, S., & Glenn, J. S. (2003). Prenylation inhibitors: a novel class of antiviral agents. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 52(6), 883-886.

Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication
Elazar, M., Cheong, K. H., Liu, P., Greenberg, H. B., Rice, C. M., & Glenn, J. S. (2003). Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication. JOURNAL OF VIROLOGY, 77(10), 6055-6061.

A prenylation inhibitor prevents production of infectious hepatitis delta virus particles
Bordier, B. B., Marion, P. L., Ohashi, K., Kay, M. A., Greenberg, H. B., & Glenn, J. S. (2002). A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. JOURNAL OF VIROLOGY, 76(20), 10465-10472.

Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses
Ohashi, K., Marion, P. L., Nakai, H., Meuse, L., Cullen, J. M., & Kay, M. A. (2000). Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses. NATURE MEDICINE, 6(3), 327-331.

Shutting the door on hepatitis delta virus (HDV): Sensitivity to prenylation inhibition prompts new therapeutic strategy
Glenn JS. (1999). Shutting the door on hepatitis delta virus (HDV): Sensitivity to prenylation inhibition prompts new therapeutic strategy. Viral Hepatitis Reviews, 53.

Use of a prenylation inhibitor as a novel antiviral agent
Glenn, J. S., Marsters, J. C., & Greenberg, H. B. (1998). Use of a prenylation inhibitor as a novel antiviral agent. JOURNAL OF VIROLOGY, 72(11), 9303-9306.

Finding the iron in the melting pot - Practical use of a new genetic assay for hereditary hemochromatosis
Glenn, J. S., & Cheung, R. C. (1998). Finding the iron in the melting pot - Practical use of a new genetic assay for hereditary hemochromatosis. WESTERN JOURNAL OF MEDICINE, 168(6), 525-527.

IDENTIFICATION OF A PRENYLATION SITE IN DELTA-VIRUS LARGE ANTIGEN
Glenn, J. S., Watson, J. A., HAVEL, C. M., & White, J. M. (1992). IDENTIFICATION OF A PRENYLATION SITE IN DELTA-VIRUS LARGE ANTIGEN. SCIENCE, 256(5061), 1331-1333.