Biography
Dr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University. She is also Director of the Joint Preservation Center and Chief of Sports Medicine at the VA Palo Alto. Previously, she was the Albert Ferguson Endowed Chair and Professor of Orthopaedic Surgery at the University of Pittsburgh. She is a clinician-scientist who is both principal investigator of several projects funded by the National Institutes of Health and who has been recognized as a Castle-Connelly/US News and World Report “Top Doctor” in Orthopedic Surgery as well as on Becker’s list of Top Knee Surgeons in the United States. Her clinical practice focuses on the knee: primarily restoration and reconstruction of the ACL, menisci and cartilage. She graduated from the U.S. Military Academy at West Point and earned her medical degree from Harvard Medical School.
As Director of the multi-disciplinary Joint Preservation Center structured to seamlessly integrate the latest advances in biologics, mechanics, and imaging with comprehensive patient centered musculoskeletal and orthopedic care, Dr. Chu aims to develop a new model for health care delivery, research and education with an emphasis on health promotion and prevention. Cornerstones of this program include teamwork and a focus on personalized medicine. A central goal is to transform the clinical approach to osteoarthritis from palliation to prevention. In addition to optimizing clinical operations, outstanding research is critical to developing more effective new treatments. Towards this end, Dr. Chu is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.
Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the AOA American, British, Canadian (ABC) and the AOSSM Traveling Fellowships.
As Director of the multi-disciplinary Joint Preservation Center structured to seamlessly integrate the latest advances in biologics, mechanics, and imaging with comprehensive patient centered musculoskeletal and orthopedic care, Dr. Chu aims to develop a new model for health care delivery, research and education with an emphasis on health promotion and prevention. Cornerstones of this program include teamwork and a focus on personalized medicine. A central goal is to transform the clinical approach to osteoarthritis from palliation to prevention. In addition to optimizing clinical operations, outstanding research is critical to developing more effective new treatments. Towards this end, Dr. Chu is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.
Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the AOA American, British, Canadian (ABC) and the AOSSM Traveling Fellowships.
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Professional Summary
Education & Certifications
- Fellowship: Brigham and Women's Hospital Orthopaedic Surgery Programs (1999) MA
- Residency: UCSD Orthopaedic Surgery (1998) CA
- Internship: UCSD Surgery Residency (1993) CA
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- Board Certification: American Board of Orthopaedic Surgery, Orthopaedic Surgery (2002)
- Medical Education: Harvard Medical School (1992) MA
- Fellowship, Drexel University, Executive Leadership in Academic Medicine (2012)
- Certificate, University of Pittsburgh Katz Business School, Physician Leadership and Management (2011)
- Undergraduate, US Military Academy at West Point (1983)
Administrative Appointments
- Chief, Sports Medicine, VA Palo Alto (2013 - Present)
- Director, Joint Preservation Center, VA Palo Alto (2013 - Present)
- Vice Chair Research, Stanford Orthopedic Surgery (2013 - Present)
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Publications
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Persistence, Localization, and External Control of Transgene Expression After Single Injection of Adeno-Associated Virus into Injured Joints
Lee, H. H., O'Malley, M. J., Friel, N. A., Payne, K. A., Qiao, C., Xiao, X., & Chu, C. R. (2013). Persistence, Localization, and External Control of Transgene Expression After Single Injection of Adeno-Associated Virus into Injured Joints. HUMAN GENE THERAPY, 24(4), 457–66. -
Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis.
Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.), 66(1), 101–6. -
Articular cartilage changes in maturing athletes: new targets for joint rejuvenation.
Luria, A., & Chu, C. R. (2014). Articular cartilage changes in maturing athletes: new targets for joint rejuvenation. Sports Health, 6(1), 18–30. -
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Quantitative Magnetic Resonance Imaging UTE-T2* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction.
Chu, C. R., Williams, A. A., West, R. V., Qian, Y., Fu, F. H., Do, B. H., & Bruno, S. (2014). Quantitative Magnetic Resonance Imaging UTE-T2* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction. American Journal of Sports Medicine, 42(8), 1847–56. -
The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes Implications for Intra-articular Injury and Therapy
Braun, H. J., Kim, H. J., Chu, C. R., & Dragoo, J. L. (2014). The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes Implications for Intra-articular Injury and Therapy. AMERICAN JOURNAL OF SPORTS MEDICINE, 42(5), 1204–10. -
Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis
Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis. ARTHRITIS & RHEUMATOLOGY, 66(1), 101–6. -
Osteoarthritis: From Palliation to Prevention: AOA Critical Issues.
Chu, C. R., Millis, M. B., & Olson, S. A. (2014). Osteoarthritis: From Palliation to Prevention: AOA Critical Issues. The Journal of Bone and Joint Surgery. American Volume, 96(15), e130. -
Serum CTXii Correlates With Articular Cartilage Degeneration After Anterior Cruciate Ligament Transection or Arthrotomy Followed by Standardized Exercise.
Coyle, C. H., Henry, S. E., Haleem, A. M., O'Malley, M. J., & Chu, C. R. (2012). Serum CTXii Correlates With Articular Cartilage Degeneration After Anterior Cruciate Ligament Transection or Arthrotomy Followed by Standardized Exercise. Sports Health, 4(6), 510–17. -
Registration of Magnetic Resonance Image Series for Knee Articular Cartilage Analysis: Data from the Osteoarthritis Initiative
Urish, K. L., Williams, A. A., Durkin, J. R., & Chu, C. R. (2013). Registration of Magnetic Resonance Image Series for Knee Articular Cartilage Analysis: Data from the Osteoarthritis Initiative. CARTILAGE, 4(1), 20–27. -
T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative
Urish, K. L., Keffalas, M. G., Durkin, J. R., Miller, D. J., Chu, C. R., & Mosher, T. J. (2013). T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative. OSTEOARTHRITIS AND CARTILAGE, 21(10), 1550–57. -
Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair
Lee, H. H., O'Malley, M. J., Friel, N. A., & Chu, C. R. (2013). Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair. OSTEOARTHRITIS AND CARTILAGE, 21(2), 385–93. -
The Role of ACL Injury in the Development of Posttraumatic Knee Osteoarthritis
Friel, N. A., & Chu, C. R. (2013). The Role of ACL Injury in the Development of Posttraumatic Knee Osteoarthritis. CLINICS IN SPORTS MEDICINE, 32(1), 1-? -
The feasibility of randomized controlled trials for early arthritis therapies (Earth) involving acute anterior cruciate ligament tear cohorts.
Chu, C. R., Beynnon, B. D., Dragoo, J. L., Fleisig, G. S., Hart, J. M., Khazzam, M., … Nelson, B. J. (2012). The feasibility of randomized controlled trials for early arthritis therapies (Earth) involving acute anterior cruciate ligament tear cohorts. American Journal of Sports Medicine, 40(11), 2648–52. -
Repeatability of ultrashort echo time-based two-component T2*measurements on cartilages in human knee at 3 T
Qian, Y., Williams, A. A., Chu, C. R., & Boada, F. E. (2013). Repeatability of ultrashort echo time-based two-component T2*measurements on cartilages in human knee at 3 T. MAGNETIC RESONANCE IN MEDICINE, 69(6), 1564–71. -
Early diagnosis to enable early treatment of pre-osteoarthritis
Chu, C. R., Williams, A. A., Coyle, C. H., & Bowers, M. E. (2012). Early diagnosis to enable early treatment of pre-osteoarthritis. ARTHRITIS RESEARCH & THERAPY, 14(3). -
UTE-T2* mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear
Williams, A., Qian, Y., Golla, S., & Chu, C. R. (2012). UTE-T2* mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear. OSTEOARTHRITIS AND CARTILAGE, 20(6), 486–94. -
Arthroscopic optical coherence tomography in diagnosis of early arthritis.
O'Malley, M. J., & Chu, C. R. (2011). Arthroscopic optical coherence tomography in diagnosis of early arthritis. Minimally Invasive Surgery, 2011, 671308-? -
High-resolution ultrashort echo time (UTE) imaging on human knee with AWSOS sequence at 3.0 T
Qian, Y., Williams, A. A., Chu, C. R., & Boada, F. E. (2012). High-resolution ultrashort echo time (UTE) imaging on human knee with AWSOS sequence at 3.0 T. JOURNAL OF MAGNETIC RESONANCE IMAGING, 35(1), 204–10. -
Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH) Report From the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II
Chu, C. R., Beynnon, B. D., Buckwalter, J. A., Garrett, W. E., Katz, J. N., Rodeo, S. A., … Stanton, R. A. (2011). Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH) Report From the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II. AMERICAN JOURNAL OF SPORTS MEDICINE, 39(7), 1569–78. -
Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees
Payne, K. A., Lee, H. H., Haleem, A. M., Martins, C., Yuan, Z., Qiao, C., … Chu, C. R. (2011). Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees. OSTEOARTHRITIS AND CARTILAGE, 19(8), 1058–65. -
Release of Bioactive Adeno-Associated Virus from Fibrin Scaffolds: Effects of Fibrin Glue Concentrations
Lee, H. H., Haleem, A. M., Yao, V., Li, J., Xiao, X., & Chu, C. R. (2011). Release of Bioactive Adeno-Associated Virus from Fibrin Scaffolds: Effects of Fibrin Glue Concentrations. TISSUE ENGINEERING PART A, 17(15-16), 1969–78. -
The Clinical Use of Human Culture-Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects: A Pilot Study and Preliminary Results
Haleem, A. M., El Singergy, A. A., Sabry, D., Atta, H. M., Rashed, L. A., Chu, C. R., … Aziz, M. T. A. (2010). The Clinical Use of Human Culture-Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects: A Pilot Study and Preliminary Results. CARTILAGE, 1(4), 253–61. -
UTE-T2* mapping of human articular cartilage in vivo: a repeatability assessment
Williams, A., Qian, Y., & Chu, C. R. (2011). UTE-T2* mapping of human articular cartilage in vivo: a repeatability assessment. OSTEOARTHRITIS AND CARTILAGE, 19(1), 84–88. -
Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.
Qian, Y., Williams, A. A., Chu, C. R., & Boada, F. E. (2010). Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo. Magnetic Resonance in Medicine , 64(5), 1426–31. -
Optical Coherence Tomography Detection of Subclinical Traumatic Cartilage Injury
Bear, D. M., Szczodry, M., Kramer, S., Coyle, C. H., Smolinski, P., & Chu, C. R. (2010). Optical Coherence Tomography Detection of Subclinical Traumatic Cartilage Injury. JOURNAL OF ORTHOPAEDIC TRAUMA, 24(9), 577–82. -
The association of osteoarthritis risk factors with localized, regional and diffuse knee pain
Thompson, L. R., Boudreau, R., Newman, A. B., Hannon, M. J., Chu, C. R., Nevitt, M. C., & Kwoh, C. K. (2010). The association of osteoarthritis risk factors with localized, regional and diffuse knee pain. OSTEOARTHRITIS AND CARTILAGE, 18(10), 1244–49. -
Clinical Optical Coherence Tomography of Early Articular Cartilage Degeneration in Patients With Degenerative Meniscal Tears
Chu, C. R., Williams, A., Tolliver, D., Kwoh, C. K., Bruno, S., & Irrgang, J. J. (2010). Clinical Optical Coherence Tomography of Early Articular Cartilage Degeneration in Patients With Degenerative Meniscal Tears. ARTHRITIS AND RHEUMATISM, 62(5), 1412–20. -
Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells
Payne, K. A., Didiano, D. M., & Chu, C. R. (2010). Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells. OSTEOARTHRITIS AND CARTILAGE, 18(5), 705–13. -
Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T-2* mapping
Williams, A., Qian, Y., Bear, D., & Chu, C. R. (2010). Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T-2* mapping. OSTEOARTHRITIS AND CARTILAGE, 18(4), 539–46. -
Progressive Chondrocyte Death After Impact Injury Indicates a Need for Chondroprotective Therapy
Szczodry, M., Coyle, C. H., Kramer, S. J., Smolinski, P., & Chu, C. R. (2009). Progressive Chondrocyte Death After Impact Injury Indicates a Need for Chondroprotective Therapy. AMERICAN JOURNAL OF SPORTS MEDICINE, 37(12), 2318–22. -
Optical Coherence Tomography Grading Correlates with MRI T2 Mapping and Extracellular Matrix Content
Bear, D. M., Williams, A., Chu, C. T., Coyle, C. H., & Chu, C. R. (2010). Optical Coherence Tomography Grading Correlates with MRI T2 Mapping and Extracellular Matrix Content. JOURNAL OF ORTHOPAEDIC RESEARCH, 28(4), 546–52. -
Animal Models for Cartilage Regeneration and Repair
Chu, C. R., Szczodry, M., & Bruno, S. (2010). Animal Models for Cartilage Regeneration and Repair. TISSUE ENGINEERING PART B-REVIEWS, 16(1), 105–15. -
The Knee Pain Map: Reliability of a Method to Identify Knee Pain Location and Pattern
Thompson, L. R., Boudreau, R., Hannon, M. J., Newman, A. B., Chu, C. R., Jansen, M., … Kwoh, C. K. (2009). The Knee Pain Map: Reliability of a Method to Identify Knee Pain Location and Pattern. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 61(6), 725–31. -
Lidocaine Potentiates the Chondrotoxicity of Methylprednisolone
Seshadri, V., Coyle, C. H., & Chu, C. R. (2009). Lidocaine Potentiates the Chondrotoxicity of Methylprednisolone. ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 25(4), 337–47. -
Novel multiarm PEG-based hydrogels for tissue engineering.
Tan, H., DeFail, A. J., Rubin, J. P., Chu, C. R., & Marra, K. G. (2010). Novel multiarm PEG-based hydrogels for tissue engineering. Journal of Biomedical Materials Research. Part A, 92(3), 979–87. -
Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering
Tan, H., Chu, C. R., Payne, K. A., & Marra, K. G. (2009). Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. BIOMATERIALS, 30(13), 2499–2506. -
Sustained Hypoxia Enhances Chondrocyte Matrix Synthesis
Coyle, C. H., Izzo, N. J., & Chu, C. R. (2009). Sustained Hypoxia Enhances Chondrocyte Matrix Synthesis. JOURNAL OF ORTHOPAEDIC RESEARCH, 27(6), 793–99. -
The Role of the Biochemical and Biophysical Environment in Chondrogenic Stem Cell Differentiation Assays and Cartilage Tissue Engineering
Wescoe, K. E., Schugar, R. C., Chu, C. R., & Deasy, B. M. (2008). The Role of the Biochemical and Biophysical Environment in Chondrogenic Stem Cell Differentiation Assays and Cartilage Tissue Engineering. CELL BIOCHEMISTRY AND BIOPHYSICS, 52(2), 85–102. -
The 2007 ABC Traveling Fellowship: building international orthopaedic bridges.
Chu, C. R., Antoniou, J., Donley, B. G., Frick, S. L., Hilibrand, A. S., Ricci, W. M., & Younger, A. S. (2008). The 2007 ABC Traveling Fellowship: building international orthopaedic bridges. Journal of Bone and Joint Surgery. American Volume, 90(3), 672–74. -
Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage
Dontchos, B. N., Coyle, C. H., Izzo, N. J., Didiano, D. M., Karpie, J. C., Logar, A., & Chu, C. R. (2008). Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage. JOURNAL OF ORTHOPAEDIC RESEARCH, 26(5), 643–50. -
Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography
Chu, C. R., Izzo, N. J., Irrgang, J. J., Ferretti, M., & Studer, R. K. (2007). Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography. JOURNAL OF BIOMEDICAL OPTICS, 12(5). -
Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro
Karpie, J. C., & Chu, C. R. (2007). Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. AMERICAN JOURNAL OF SPORTS MEDICINE, 35(10), 1621–27. -
Adeno-associated viral gene transfer of transforming growth factor-beta 1 to human mesenchymal stem cells improves cartilage repair
Pagnotto, M. R., Wang, Z., Karpie, J. C., Ferretti, M., Xiao, X., & Chu, C. R. (2007). Adeno-associated viral gene transfer of transforming growth factor-beta 1 to human mesenchymal stem cells improves cartilage repair. GENE THERAPY, 14(10), 804–13. -
Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels within osteochondral defects
Ferretti, M., Marra, K. G., Kobayashi, K., DeFail, A. J., & Chu, C. R. (2006). Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels within osteochondral defects. TISSUE ENGINEERING, 12(9), 2657–63. -
In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes
Chu, C. R., Izzo, N. J., Papas, N. E., & Fu, F. H. (2006). In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 22(7), 693–99. -
Controlled release of bioactive TGF-beta(1) from microspheres embedded within biodegradable hydrogels
DeFail, A. J., Chu, C. R., Izzo, N., & Marra, K. G. (2006). Controlled release of bioactive TGF-beta(1) from microspheres embedded within biodegradable hydrogels. BIOMATERIALS, 27(8), 1579–85. -
Adenoviral-mediated transfer of TGF-beta 1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures
Kawamura, K., Chu, C. R., Sobajima, S., Robbins, P. D., Fu, F. H., Izzo, N. J., & Niyibizi, C. (2005). Adenoviral-mediated transfer of TGF-beta 1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. EXPERIMENTAL HEMATOLOGY, 33(8), 865–72. -
p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta
Studer, R. K., & Chu, C. R. (2005). p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta. JOURNAL OF ORTHOPAEDIC RESEARCH, 23(2), 454–61. -
Mini-pig fresh osteochondral allografts deteriorate after 1 week of cold storage
Rohde, R. S., Studer, R. K., & Chu, C. R. (2004). Mini-pig fresh osteochondral allografts deteriorate after 1 week of cold storage. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (427), 226–33. -
Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor
Chu, C. R., Kaplan, L. D., Fu, F. H., Crossett, L. S., & Studer, R. K. (2004). Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor. AMERICAN JOURNAL OF SPORTS MEDICINE, 32(1), 191–96. -
Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage
Pan, Y. T., Li, Z. G., Xie, T. Q., & Chu, C. R. (2003). Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage. JOURNAL OF BIOMEDICAL OPTICS, 8(4), 648–54. -
Recovery of chondrocyte metabolic activity after thermal exposure
Kaplan, L. D., Chu, C. R., Bradley, J. P., Fu, F. H., & Studer, R. K. (2003). Recovery of chondrocyte metabolic activity after thermal exposure. AMERICAN JOURNAL OF SPORTS MEDICINE, 31(3), 392–98. -
Analysis of rabbit articular cartilage repair after chondrocyte implantation using optical coherence tomography
Han, C. W., Chu, C. R., Adachi, N., Usas, A., Fu, F. H., Huard, J., & Pan, Y. (2003). Analysis of rabbit articular cartilage repair after chondrocyte implantation using optical coherence tomography. OSTEOARTHRITIS AND CARTILAGE, 11(2), 111–21. -
Articular cartilage transplantation - Clinical results in the knee
Chu, C. R., Convery, F. R., Akeson, W. H., Meyers, M., & Amiel, D. (1999). Articular cartilage transplantation - Clinical results in the knee. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (360), 159–68. -
The Marshall R. Urist Young Investigator Award. Autogenous flexor tendon grafts. Biologic mechanisms for incorporation.
Seiler, J. G., Chu, C. R., Amiel, D., Woo, S. L., & Gelberman, R. H. (1997). The Marshall R. Urist Young Investigator Award. Autogenous flexor tendon grafts. Biologic mechanisms for incorporation. Clinical Orthopaedics and Related Research, (345), 239–247. -
Osteochondral repair using perichondrial cells - A 1-year study in rabbits
Chu, C. R., Dounchis, J. S., Yoshioka, M., Sah, R. L., Coutts, R. D., & Amiel, D. (1997). Osteochondral repair using perichondrial cells - A 1-year study in rabbits. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (340), 220–229. -
IN-SITU ASSESSMENT OF CELL VIABILITY WITHIN BIODEGRADABLE POLYLACTIC ACID POLYMER MATRICES
Chu, C. R., Monosov, A. Z., & Amiel, D. (1995). IN-SITU ASSESSMENT OF CELL VIABILITY WITHIN BIODEGRADABLE POLYLACTIC ACID POLYMER MATRICES. BIOMATERIALS, 16(18), 1381–1384. -
ARTICULAR-CARTILAGE REPAIR USING ALLOGENEIC PERICHONDROCYTE-SEEDED BIODEGRADABLE POROUS POLYLACTIC ACID (PLA) - A TISSUE-ENGINEERING STUDY
Chu, C. R., Coutts, R. D., Yoshioka, M., Harwood, F. L., Monosov, A. Z., & Amiel, D. (1995). ARTICULAR-CARTILAGE REPAIR USING ALLOGENEIC PERICHONDROCYTE-SEEDED BIODEGRADABLE POROUS POLYLACTIC ACID (PLA) - A TISSUE-ENGINEERING STUDY. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 29(9), 1147–1154. -
AUTOGENOUS INTRASYNOVIAL AND EXTRASYNOVIAL TENDON GRAFTS - AN EXPERIMENTAL-STUDY OF PRO ALPHA-1(I) COLLAGEN MESSENGER-RNA EXPRESSION IN DOGS
Amiel, D., Harwood, F. L., Gelberman, R. H., Chu, C. R., Seiler, J. G., & Abrahamsson, S. (1995). AUTOGENOUS INTRASYNOVIAL AND EXTRASYNOVIAL TENDON GRAFTS - AN EXPERIMENTAL-STUDY OF PRO ALPHA-1(I) COLLAGEN MESSENGER-RNA EXPRESSION IN DOGS. JOURNAL OF ORTHOPAEDIC RESEARCH, 13(3), 459–463. -
AUTOGENOUS FLEXOR-TENDON GRAFTS - A BIOMECHANICAL AND MORPHOLOGICAL-STUDY IN DOGS
Seiler, J. G., Gelberman, R. H., Williams, C. S., Woo, S. L. Y., Dickersin, G. R., SOFRANKO, R., … Rosenberg, A. E. (1993). AUTOGENOUS FLEXOR-TENDON GRAFTS - A BIOMECHANICAL AND MORPHOLOGICAL-STUDY IN DOGS. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 75A(7), 1004–14. -
ANGIOGENESIS IN HEALING AUTOGENOUS FLEXOR-TENDON GRAFTS
Gelberman, R. H., Chu, C. R., Williams, C. S., Seiler, J. G., & Amiel, D. (1992). ANGIOGENESIS IN HEALING AUTOGENOUS FLEXOR-TENDON GRAFTS. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 74A(8), 1207–1216. -
The in vitro effects of bupivacaine on articular chondrocytes
Chu, C. R., Izzo, N. J., Coyle, C. H., Papas, N. E., & Logar, A. (2008). The in vitro effects of bupivacaine on articular chondrocytes. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 90B(6), 814–20. -
In Vivo Effects of Single Intra-Articular Injection of 0.5% Bupivacaine on Articular Cartilage
Chu, C. R., Coyle, C. H., Chu, C. T., Szczodry, M., Seshadri, V., Karpie, J. C., … Pringle, E. K. (2010). In Vivo Effects of Single Intra-Articular Injection of 0.5% Bupivacaine on Articular Cartilage. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 92A(3), 599–608. -
The in vitro effects of bupivacaine on articular chondrocytes.
Chu, C. R., Izzo, N. J., Coyle, C. H., Papas, N. E., & Logar, A. (2008). The in vitro effects of bupivacaine on articular chondrocytes. Journal of Bone and Joint Surgery. British Volume, 90(6), 814–20. -
In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage.
Chu, C. R., Coyle, C. H., Chu, C. T., Szczodry, M., Seshadri, V., Karpie, J. C., … Pringle, E. K. (2010). In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. Journal of Bone and Joint Surgery. American Volume, 92(3), 599–608. -
The fate of autogenous tendon grafts.
Seiler, J. G., Chu, C., ABRAHAMSSON, S. O., & Gelberman, R. H. (1993). The fate of autogenous tendon grafts. The Iowa Orthopaedic Journal, 13, 56–62. -
Effects of high heel wear and increased weight on the knee during walking.
Titchenal, M. R., Asay, J. L., Favre, J., Andriacchi, T. P., & Chu, C. R. (2015). Effects of high heel wear and increased weight on the knee during walking. Journal of Orthopaedic Research , 33(3), 405–11. -
Quantitative Magnetic Resonance Imaging UTE-T2*Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction
Chu, C. R., Williams, A. A., West, R. V., Qian, Y., Fu, F. H., Do, B. H., & Bruno, S. (2014). Quantitative Magnetic Resonance Imaging UTE-T2*Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction. AMERICAN JOURNAL OF SPORTS MEDICINE, 42(8), 1847–56. -
A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease
Andriacchi, T. P., Favre, J., Erhart-Hledik, J. C., & Chu, C. R. (2015). A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease. ANNALS OF BIOMEDICAL ENGINEERING, 43(2), 376–87. -
Multicomponent T-2(star) Mapping of Knee Cartilage: Technical Feasibility Ex Vivo
Qian, Y., Williams, A. A., Chu, C. R., & Boada, F. E. (2010). Multicomponent T-2(star) Mapping of Knee Cartilage: Technical Feasibility Ex Vivo. MAGNETIC RESONANCE IN MEDICINE, 64(5), 1427–32. -
Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete
Lee, H. H., & Chu, C. R. (2012). Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete. CARTILAGE, 3(1), 63S–68S. -
The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair
Chu, C. R. (2015). The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair. CARTILAGE, 6(2), 36S–45S. -
Osteoarthritis: From Palliation to Prevention AOA Critical Issues
Chu, C. R., Millis, M. B., & Olson, S. A. (2014). Osteoarthritis: From Palliation to Prevention AOA Critical Issues. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 96A(15). -
Dance between biology, mechanics, and structure: A systems-based approach to developing osteoarthritis prevention strategies
Chu, C. R., & Andriacchi, T. P. (2015). Dance between biology, mechanics, and structure: A systems-based approach to developing osteoarthritis prevention strategies. JOURNAL OF ORTHOPAEDIC RESEARCH, 33(7), 939–47. -
Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects Does It Enhance Repair?
Goodrich, L. R., Chen, A. C., Werpy, N. M., Williams, A. A., Kisiday, J. D., Su, A. W., … Chu, C. R. (2016). Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects Does It Enhance Repair? JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 98A(1), 23–34. -
Novel multiarm PEG-based hydrogels for tissue engineering
Tan, H., DeFail, A. J., Rubin, J. P., Chu, C. R., & Marra, K. G. (2010). Novel multiarm PEG-based hydrogels for tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(3), 979–87. -
Autogenous flexor tendon grafts - Biologic mechanisms for incorporation
Seiler, J. G., Chu, C. R., Amiel, D., Woo, S. L. Y., & Gelberman, R. H. (1997). Autogenous flexor tendon grafts - Biologic mechanisms for incorporation. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (345), 239–247. -
AAOS Research Symposium Updates and Consensus: Biologic Treatment of Orthopaedic Injuries
LaPrade, R. F., Dragoo, J. L., Koh, J. L., Murray, I. R., Geeslin, A. G., & Chu, C. R. (2016). AAOS Research Symposium Updates and Consensus: Biologic Treatment of Orthopaedic Injuries. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 24(7), E62–E78. -
Novel quantitative imaging for early detection of joint tissue injury to support early treatment strategies.
Stepp, P. C., Williams, A. A., & Chu, C. (2012). Novel quantitative imaging for early detection of joint tissue injury to support early treatment strategies. HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery, 8(1), 54–56. -
Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair?
Goodrich, L. R., Chen, A. C., Werpy, N. M., Williams, A. A., Kisiday, J. D., Su, A. W., … Chu, C. R. (2016). Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair? Journal of Bone and Joint Surgery. American Volume, 98(1), 23–34. -
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.
Raghu, H., Lepus, C. M., Wang, Q., Wong, H. H., Lingampalli, N., Oliviero, F., … Robinson, W. H. (2016). CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. Annals of the Rheumatic Diseases. -
Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes.
Titchenal, M. R., Chu, C. R., Erhart-Hledik, J. C., & Andriacchi, T. P. (2016). Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes. American Journal of Sports Medicine. -
Effects of active feedback gait retraining to produce a medial weight transfer at the foot in subjects with symptomatic medial knee osteoarthritis.
Erhart-Hledik, J. C., Asay, J. L., Clancy, C., Chu, C. R., & Andriacchi, T. P. (2017). Effects of active feedback gait retraining to produce a medial weight transfer at the foot in subjects with symptomatic medial knee osteoarthritis. Journal of Orthopaedic Research . -
Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes.
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2016). Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes. Journal of Orthopaedic Research . -
Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness.
Williams, A., Winalski, C. S., & Chu, C. R. (2016). Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness. Journal of Orthopaedic Research . -
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis
Raghu, H., Lepus, C. M., Wang, Q., Wong, H. H., Lingampalli, N., Oliviero, F., … Robinson, W. H. (2017). CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. ANNALS OF THE RHEUMATIC DISEASES, 76(5). -
Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes
Titchenal, M. R., Chu, C. R., Erhart-Hledik, J. C., & Andriacchi, T. P. (2017). Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes. AMERICAN JOURNAL OF SPORTS MEDICINE, 45(4), 915–21. -
Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2017). Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes. JOURNAL OF ORTHOPAEDIC RESEARCH, 35(3), 634–40. -
Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness
Williams, A., Winalski, C. S., & Chu, C. R. (2017). Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness. JOURNAL OF ORTHOPAEDIC RESEARCH, 35(3), 699–706. -
Environmental durability of protected silver mirrors prepared by plasma beam sputtering
Folgner, K. A., Chu, C.-T., Lingley, Z. R., Kim, H. I., Yang, J.-M., & Barrie, J. D. (2017). Environmental durability of protected silver mirrors prepared by plasma beam sputtering. APPLIED OPTICS, 56(4), C75–C86. -
Synovial Fluid Lubricant Properties are Transiently Deficient after Arthroscopic Articular Cartilage Defect Repair with Platelet-Enriched Fibrin Alone and with Mesenchymal Stem Cells.
Grissom, M. J., Temple-Wong, M. M., Adams, M. S., Tom, M., Schumacher, B. L., McIlwraith, C. W., … Sah, R. L. (2014). Synovial Fluid Lubricant Properties are Transiently Deficient after Arthroscopic Articular Cartilage Defect Repair with Platelet-Enriched Fibrin Alone and with Mesenchymal Stem Cells. Orthopaedic Journal of Sports Medicine, 2(7). -
Mechanically stimulated biomarkers signal cartilage changes over 5 years consistent with disease progression in medial knee osteoarthritis patients.
Chu, C. R., Sheth, S., Erhart-Hledik, J. C., Do, B., Titchenal, M. R., & Andriacchi, T. P. (2017). Mechanically stimulated biomarkers signal cartilage changes over 5 years consistent with disease progression in medial knee osteoarthritis patients. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. -
Cartilage Subsurface Changes to Magnetic Resonance Imaging UTE-T2*2 Years After Anterior Cruciate Ligament Reconstruction Correlate With Walking Mechanics Associated With Knee Osteoarthritis
Titchenal, M. R., Williams, A. A., Chehab, E. F., Asay, J. L., Dragoo, J. L., Gold, G. E., … Chu, C. R. (2018). Cartilage Subsurface Changes to Magnetic Resonance Imaging UTE-T2*2 Years After Anterior Cruciate Ligament Reconstruction Correlate With Walking Mechanics Associated With Knee Osteoarthritis. AMERICAN JOURNAL OF SPORTS MEDICINE, 46(3), 565–72. -
Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma
Xiong, G., Lingampalli, N., Koltsov, J. C. B., Leung, L. L., Bhutani, N., Robinson, W. H., & Chu, C. R. (2018). Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma. AMERICAN JOURNAL OF SPORTS MEDICINE, 46(2), 409–19. -
Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction.
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2018). Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 36(5), 1478–86. -
MRI UTE-T2*profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction
Williams, A. A., Titchenal, M. R., Andriacchi, T. P., & Chu, C. R. (2018). MRI UTE-T2*profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction. OSTEOARTHRITIS AND CARTILAGE, 26(4), 569–79. -
MECHANICALLY STIMULATED CS846 CORRELATES WITH ULTRASHORT ECHO TIME ENHANCED T2*QUANTITATIVE MRI AND GAIT MECHANICS 2 YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Titchenal, M. R., Williams, A. A., Asay, J. L., Migliore, E., Erhart-Hledik, J. C., Andriacchi, T. P., & Chu, C. R. (2018). MECHANICALLY STIMULATED CS846 CORRELATES WITH ULTRASHORT ECHO TIME ENHANCED T2*QUANTITATIVE MRI AND GAIT MECHANICS 2 YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION. OSTEOARTHRITIS AND CARTILAGE, 26, S176–S177. -
ACTIVE FEEDBACK GAIT RETRAINING ALTERS FOOT PRESSURE PATTERNS AND REDUCES KNEE ADDUCTION MOMENT IN AN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED POPULATION
Erhart-Hledik, J. C., Mahtani, G. B., Asay, J. L., Chu, C. R., & Andriacchi, T. P. (2018). ACTIVE FEEDBACK GAIT RETRAINING ALTERS FOOT PRESSURE PATTERNS AND REDUCES KNEE ADDUCTION MOMENT IN AN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED POPULATION. OSTEOARTHRITIS AND CARTILAGE, 26, S364. -
Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1 beta
Lee, J., Smeriglio, P., Chu, C. R., & Bhutani, N. (2017). Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1 beta. STEM CELL RESEARCH & THERAPY, 8, 244. -
Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects A One-Year Study in an Equine Model
Chu, C. R., Fortier, L. A., Williams, A., Payne, K. A., McCarrel, T. M., Bowers, M. E., & Jaramillo, D. (2018). Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects A One-Year Study in an Equine Model. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 100(2), 138–46. -
MRI UTE-T2* Shows High Incidence of Cartilage Subsurface Matrix Changes 2 Years After ACL Reconstruction.
Williams, A. A., Titchenal, M. R., Do, B. H., Guha, A., & Chu, C. R. (2018). MRI UTE-T2* Shows High Incidence of Cartilage Subsurface Matrix Changes 2 Years After ACL Reconstruction. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. -
Advances in Tissue Engineering Techniques for Articular Cartilage Repair.
Haleem, A. M., & Chu, C. R. (2010). Advances in Tissue Engineering Techniques for Articular Cartilage Repair. Operative Techniques in Orthopaedics, 20(2), 76–89. -
PROSPECTIVE CHANGES IN CARTILAGE THICKNESS CORRELATE WITH KNEE KINEMATICS AT PEAK LOADING DURING WALKING FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Titchenal, M. R., Chu, C. R., & Andriacchi, T. P. (2016). PROSPECTIVE CHANGES IN CARTILAGE THICKNESS CORRELATE WITH KNEE KINEMATICS AT PEAK LOADING DURING WALKING FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION. OSTEOARTHRITIS AND CARTILAGE, 24, S98–S99. -
DOXYCYCLINE CONTROL OF LOCALIZED IN VIVO TRANSGENE EXPRESSION IN CARTILAGE INJURED JOINTS
Lee, H. H., O'Malley, M. J., Payne, K. A., Xiao, X., & Chu, C. R. (2011). DOXYCYCLINE CONTROL OF LOCALIZED IN VIVO TRANSGENE EXPRESSION IN CARTILAGE INJURED JOINTS. OSTEOARTHRITIS AND CARTILAGE, 19, S111. -
PROSPECTIVE CHANGES IN THE KNEE JOINT CENTER OF ROTATION RELATIVE TO THE CONTRALATERAL KNEE AND OVER TIME PROVIDE A COMPREHENSIVE VIEW OF KINEMATIC CHANGES FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Titchenal, M., Chu, C. R., & Andriacchi, T. P. (2015). PROSPECTIVE CHANGES IN THE KNEE JOINT CENTER OF ROTATION RELATIVE TO THE CONTRALATERAL KNEE AND OVER TIME PROVIDE A COMPREHENSIVE VIEW OF KINEMATIC CHANGES FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION. OSTEOARTHRITIS AND CARTILAGE, 23, A96–A97. -
T2 TEXTURE INDEX OF CARTILAGE CAN PREDICT EARLY SYMPTOMATIC OA PROGRESSION: DATA FROM THE OSTEOARTHRITIS INITIATIVE
Urish, K. L., Keffalas, M. G., Durkin, J. R., Miller, D. J., Chu, C. R., & Mosher, T. J. (2013). T2 TEXTURE INDEX OF CARTILAGE CAN PREDICT EARLY SYMPTOMATIC OA PROGRESSION: DATA FROM THE OSTEOARTHRITIS INITIATIVE. OSTEOARTHRITIS AND CARTILAGE, 21, S10–S11. -
TGF-beta TYPE II RECEPTOR AS A NOVEL INDICATOR OF CHONDROGENESIS IN EQUINE BONE MARROW-DERIVED MESENCHYMAL STEM CELLS
Suter, K. K., Payne, K. A., Yao, V., Fortier, L. A., & Chu, C. R. (2011). TGF-beta TYPE II RECEPTOR AS A NOVEL INDICATOR OF CHONDROGENESIS IN EQUINE BONE MARROW-DERIVED MESENCHYMAL STEM CELLS. OSTEOARTHRITIS AND CARTILAGE, 19, S115–S116. -
IN VIVO MRI UTE-T2*IS ELEVATED IN BOTH TORN AND SURFACE INTACT HUMAN MENISCI OF ANTERIOR CRUCIATE LIGAMENT INJURED KNEES
Williams, A., Qian, Y., Chu, C. R., & Bowers, M. (2011). IN VIVO MRI UTE-T2*IS ELEVATED IN BOTH TORN AND SURFACE INTACT HUMAN MENISCI OF ANTERIOR CRUCIATE LIGAMENT INJURED KNEES. OSTEOARTHRITIS AND CARTILAGE, 19, S11–S12. -
Localization and Persistence of Transgene Expression Following Intra-Articular Injection of Adeno-Associated Virus into the Rat Knee
Payne, K. A., Martins, C., Lee, H. H., Xiao, X., & Chu, C. R. (2009). Localization and Persistence of Transgene Expression Following Intra-Articular Injection of Adeno-Associated Virus into the Rat Knee. MOLECULAR THERAPY, 17, S79. -
Novel MRI Ultrashort TE Enhanced T Mapping Shows Subsurface Cartilage and Meniscus Changes Clinically in Human Subjects After Anterior Cruciate Ligament Tear (ACLT)
Chu, C. R., Williams, A. A., & Qian, Y. (2011). Novel MRI Ultrashort TE Enhanced T Mapping Shows Subsurface Cartilage and Meniscus Changes Clinically in Human Subjects After Anterior Cruciate Ligament Tear (ACLT). ARTHRITIS AND RHEUMATISM, 63(10), S635–S636. -
Short-term Analysis vs Long-term Data on Total Hip Replacement Survivorship
Chu, C. R. (2015). Short-term Analysis vs Long-term Data on Total Hip Replacement Survivorship. JAMA SURGERY, 150(10), 989. -
BILATERAL ASSESSMENT OF CARTILAGE WITH UTE-T2*QUANTITATIVE MRI AND ASSOCIATIONS WITH KNEE CENTER OF ROTATION FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Titchenal, M. R., Williams, A. A., Asay, J. L., Andriacchi, T. P., & Chu, C. R. (2017). BILATERAL ASSESSMENT OF CARTILAGE WITH UTE-T2*QUANTITATIVE MRI AND ASSOCIATIONS WITH KNEE CENTER OF ROTATION FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION. OSTEOARTHRITIS AND CARTILAGE, 25, S120–S121. -
Defining Pre-Osteoarthritis Is Key to Prevention
Chu, C. R. (2016). Defining Pre-Osteoarthritis Is Key to Prevention. CARTILAGE, 7(2), 204. -
REPEATED SUB-THRESHOLD DOSING OF TGF-BETA1 IS INEFFECTIVE IN STIMULATING HUMAN BONE MARROW CELLS: IMPLICATIONS FOR CARTILAGE REPAIR STRATEGIES
Yao, V., Payne, K. A., & Chu, C. R. (2010). REPEATED SUB-THRESHOLD DOSING OF TGF-BETA1 IS INEFFECTIVE IN STIMULATING HUMAN BONE MARROW CELLS: IMPLICATIONS FOR CARTILAGE REPAIR STRATEGIES. OSTEOARTHRITIS AND CARTILAGE, 18, S86. -
SIGNAL HOMOGENEITY ON CARTILAGE T2 MAPS AS A PREDICTIVE IMAGE BIOMARKER FOR RAPID SYMPTOMATIC PROGRESSION OF OA
Urish, K. L., Keffalas, M. G., Miller, D. J., Durkin, J., Chu, C. R., & Mosher, T. J. (2011). SIGNAL HOMOGENEITY ON CARTILAGE T2 MAPS AS A PREDICTIVE IMAGE BIOMARKER FOR RAPID SYMPTOMATIC PROGRESSION OF OA. OSTEOARTHRITIS AND CARTILAGE, 19, S190. -
SIDE-TO-SIDE DIFFERENCES IN KINEMATICS AND KINETICS TWO YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION ARE ASSOCIATED WITH LONGER-TERM CHANGES IN PATIENT-REPORTED OUTCOMES
Erhart-Hledik, J., Chu, C., Asay, J., & Andriacchi, T. (2016). SIDE-TO-SIDE DIFFERENCES IN KINEMATICS AND KINETICS TWO YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION ARE ASSOCIATED WITH LONGER-TERM CHANGES IN PATIENT-REPORTED OUTCOMES. OSTEOARTHRITIS AND CARTILAGE, 24, S90–S91. -
SINGLE INTRA-ARTICULAR INJECTION RESULTS IN STABLE AND CONTROLLABLE IN VIVO TRANSGENE EXPRESSION
Payne, K. A., Lee, H. H., Haleem, A. M., Martin, C., Xiao, X., & Chu, C. R. (2010). SINGLE INTRA-ARTICULAR INJECTION RESULTS IN STABLE AND CONTROLLABLE IN VIVO TRANSGENE EXPRESSION. OSTEOARTHRITIS AND CARTILAGE, 18, S22. -
The distillation curve and sooting propensity of a typical jet fuel
Saggese, C., Singh, A. V., Xue, X., Chu, C., Kholghy, M. R., Zhang, T., … Wang, H. (2019). The distillation curve and sooting propensity of a typical jet fuel. Fuel, 235. -
Proceedings of the signature series symposium "cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," international society for cellular therapies, montreal, canada, may 2, 2018.
Piuzzi, N. S., Dominici, M., Long, M., Pascual-Garrido, C., Rodeo, S., Huard, J., … Muschler, G. F. (2018). Proceedings of the signature series symposium "cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," international society for cellular therapies, montreal, canada, may 2, 2018. Cytotherapy. -
Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes.
Fischer, A. G., Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2019). Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes. Gait & Posture, 69, 91–95. -
Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference
Chu, C. R., Rodeo, S., Bhutani, N., Goodrich, L. R., Huard, J., Irrgang, J., … Maloney, W. (2019). Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 27(2), E50–E63. -
The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair.
Chu, C. R. (2015). The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair. Cartilage, 6(2 Suppl), 36S–45S. -
Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete.
Lee, H. H., & Chu, C. R. (2012). Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete. Cartilage, 3(1 Suppl), 63S–8S. -
Platelet-Rich Plasma (PRP) from Older Males with Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation.
O'Donnell, C., Migliore, E., Grandi, F. C., Koltsov, J., Lingampalli, N., Cisar, C., … Chu, C. R. (2019). Platelet-Rich Plasma (PRP) from Older Males with Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. -
Adaptive Sports and the Warrior Athlete.
Chu, C. R., Diaz, R., & Syrop, I. P. (2019). Adaptive Sports and the Warrior Athlete. Sports Medicine and Arthroscopy Review, 27(2), 41. -
ACTIVATING THE SOMATOSENSORY SYSTEM ENHANCES KNEE FLEXION AND QUADRICEPS ACTIVITY DURING GAIT AND STAIR CLIMBING
Fischer, A. G., Erhart-Hledik, J. C., Asay, J. L., Chu, C. R., & Andriacchi, T. P. (2019). ACTIVATING THE SOMATOSENSORY SYSTEM ENHANCES KNEE FLEXION AND QUADRICEPS ACTIVITY DURING GAIT AND STAIR CLIMBING. OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. -
CHANGES IN KNEE ADDUCTION MOMENT WITH A VARIABLE-STIFFNESS SHOE ARE RELATED TO CHANGES IN PAIN AND FUNCTION
Erhart-Hledik, J., Mahtani, G., Asay, J., Andriacchi, T., & Chu, C. (2019). CHANGES IN KNEE ADDUCTION MOMENT WITH A VARIABLE-STIFFNESS SHOE ARE RELATED TO CHANGES IN PAIN AND FUNCTION. OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. -
Activating the somatosensory system enhances net quadriceps moment during gait
Fischer, A. G., Erhart-Hledik, J. C., Asay, J. L., Chu, C. R., & Andriacchi, T. P. (2019). Activating the somatosensory system enhances net quadriceps moment during gait. JOURNAL OF BIOMECHANICS, 82, 149–55. -
MRI UTE-T2*shows high incidence of cartilage subsurface matrix changes 2 years after ACL reconstruction
Williams, A. A., Titchenal, M. R., Do, B. H., Guha, A., & Chu, C. R. (2019). MRI UTE-T2*shows high incidence of cartilage subsurface matrix changes 2 years after ACL reconstruction. JOURNAL OF ORTHOPAEDIC RESEARCH, 37(2), 370–77. -
Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2018). Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction. JOURNAL OF ORTHOPAEDIC RESEARCH, 36(5), 1478–86. -
Synovial Fluid Lubricant Properties Are Transiently Deficient After Arthroscopic Articular Cartilage Defect Repair With Platelet-Enriched Fibrin Alone and With Mesenchymal Stem Cells
Grissom, M. J., Temple-Wong, M. M., Adams, M. S., Tom, M., Schumacher, B. L., McIlwraith, W., … Sah, R. L. (2014). Synovial Fluid Lubricant Properties Are Transiently Deficient After Arthroscopic Articular Cartilage Defect Repair With Platelet-Enriched Fibrin Alone and With Mesenchymal Stem Cells. ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE, 2(7). -
Advances in Tissue Engineering Techniques for Articular Cartilage Repair
Haleem, A. M., & Chu, C. R. (2010). Advances in Tissue Engineering Techniques for Articular Cartilage Repair. OPERATIVE TECHNIQUES IN ORTHOPAEDICS, 20(2), 76–89. -
Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes
Fischer, A. G., Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., & Andriacchi, T. P. (2019). Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes. GAIT & POSTURE, 69, 91–95. -
Longitudinal Changes in the Total Knee Joint Moment After Anterior Cruciate Ligament Reconstruction Correlate With Cartilage Thickness Changes
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., Favre, J., & Andriacchi, T. P. (2019). Longitudinal Changes in the Total Knee Joint Moment After Anterior Cruciate Ligament Reconstruction Correlate With Cartilage Thickness Changes. JOURNAL OF ORTHOPAEDIC RESEARCH, 37(7), 1546–54. -
Classification systems for platelet-rich plasma.
Rossi, L. A., Murray, I. R., Chu, C. R., Muschler, G. F., Rodeo, S. A., & Piuzzi, N. S. (2019). Classification systems for platelet-rich plasma. The Bone & Joint Journal, 101-B(8), 891–96. -
Platelet-Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation
O'Donnell, C., Migliore, E., Grandi, F. C., Koltsov, J., Lingampalli, N., Cisar, C., … Chu, C. R. (2019). Platelet-Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation. JOURNAL OF ORTHOPAEDIC RESEARCH, 37(8), 1760–70. -
Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage
Grandi, F. C., Baskar, R., Smeriglio, P., Murkherjee, S., Indelli, P. F., F. Amanatullah, D., … Bhutani, N. (2020). Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage. Science Advances , 6(11). -
VARIABLE RESPONSES IN PAIN AND FUNCTION 1 MONTH AFTER PLATELET-RICH PLASMA INJECTION ARE RELATED TO CHANGES IN JOINT LOADING DURING GAIT
Erhart-Hledik, J., Mahtani, G., Asay, J., Burt, H., Nguyen, M., Do, B., … Chu, C. (2020). VARIABLE RESPONSES IN PAIN AND FUNCTION 1 MONTH AFTER PLATELET-RICH PLASMA INJECTION ARE RELATED TO CHANGES IN JOINT LOADING DURING GAIT. OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. -
SIDE-TO-SIDE DIFFERENCES IN VERTICAL GROUND REACTION FORCE TWO YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION PREDICT LONGITUDINAL CHANGES IN PATIENT-REPORTED OUTCOMES
Erhart-Hledik, J., Chu, C., Asay, J., Mahtani, G., & Andriacchi, T. (2020). SIDE-TO-SIDE DIFFERENCES IN VERTICAL GROUND REACTION FORCE TWO YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION PREDICT LONGITUDINAL CHANGES IN PATIENT-REPORTED OUTCOMES. OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. -
TRUNK MOVEMENT PATTERNS ARE ASSOCIATED WITH KNEE FLEXION MOMENT CHANGES WHILE UTILIZING THE SOMATOSENSORY SYSTEM DURING STAIR CLIMBING: CLINICAL TRIAL CROSSOVER STUDY
Fischer, A. G., Erhart-Hledik, J. C., Asay, J. L., Chu, C. R., & Andriacchi, T. P. (2020). TRUNK MOVEMENT PATTERNS ARE ASSOCIATED WITH KNEE FLEXION MOMENT CHANGES WHILE UTILIZING THE SOMATOSENSORY SYSTEM DURING STAIR CLIMBING: CLINICAL TRIAL CROSSOVER STUDY. OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. -
Changes in Knee Adduction Moment Wearing a Variable-Stiffness Shoe Correlate with Changes in Pain and Mechanically-Stimulated Cartilage Oligomeric Matrix Levels.
Erhart-Hledik, J. C., Mahtani, G. B., Asay, J. L., Migliore, E., Nguyen, M. M., Andriacchi, T. P., & Chu, C. R. (2020). Changes in Knee Adduction Moment Wearing a Variable-Stiffness Shoe Correlate with Changes in Pain and Mechanically-Stimulated Cartilage Oligomeric Matrix Levels. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. -
Comparison of Autologous Chondrocyte Implantation and Osteochondral Allograft Transplantation of the Knee in a Large Insurance Database: Reoperation Rate, Complications, and Cost Analysis.
Sochacki, K. R., Varshneya, K., Calcei, J. G., Safran, M. R., Abrams, G. D., Donahue, J., … Sherman, S. L. (2020). Comparison of Autologous Chondrocyte Implantation and Osteochondral Allograft Transplantation of the Knee in a Large Insurance Database: Reoperation Rate, Complications, and Cost Analysis. Cartilage, 1947603520967065. -
Platelet-Rich Plasma Augmentation for Isolated Arthroscopic Meniscal Repairs Leads to Significantly Lower Failure Rates: A Systematic Review of Comparative Studies.
Sochacki, K. R., Safran, M. R., Abrams, G. D., Donahue, J., Chu, C., & Sherman, S. L. (2020). Platelet-Rich Plasma Augmentation for Isolated Arthroscopic Meniscal Repairs Leads to Significantly Lower Failure Rates: A Systematic Review of Comparative Studies. Orthopaedic Journal of Sports Medicine, 8(11), 2325967120964534. -
Longitudinal changes in tibial and femoral cartilage thickness are associated with baseline ambulatory kinetics and cartilage oligomeric matrix protein (COMP) measures in an asymptomatic aging population.
Erhart-Hledik, J. C., Chehab, E. F., Asay, J. L., Favre, J., Chu, C. R., & Andriacchi, T. P. (2021). Longitudinal changes in tibial and femoral cartilage thickness are associated with baseline ambulatory kinetics and cartilage oligomeric matrix protein (COMP) measures in an asymptomatic aging population. Osteoarthritis and Cartilage. -
Vertical Ground Reaction Force 2 Years After Anterior Cruciate Ligament Reconstruction Predicts 10-Year Patient-Reported Outcomes.
Erhart-Hledik, J. C., Chu, C. R., Asay, J. L., Mahtani, G. B., & Andriacchi, T. P. (2021). Vertical Ground Reaction Force 2 Years After Anterior Cruciate Ligament Reconstruction Predicts 10-Year Patient-Reported Outcomes. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society.
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Quantitative Magnetic Resonance Imaging UTE-T2* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
Orthopaedics and Sports Medicine in Redwood City Redwood City, CA
Redwood City, CA
Orthopaedics and Sports Medicine in Redwood City
450 Broadway St
Redwood City , CA 94063
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Referring Physicians
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Fax: 650-320-9443
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