Emmanuel Mignot is the Craig Reynolds Professor of Sleep Medicine in the Department of Psychiatry and Behavioral Sciences at Stanford University and the Director of the Stanford Center for Narcolepsy. He is recognized as having discovered the cause of narcolepsy. Dr. Mignot was born In Paris, France, and he is a former student of the Ecole Normale Superieure (Ulm, Paris, France). He received his M.D. and Ph.D. (molecular pharmacology) from Paris V and VI University respectively. He practiced medicine and Psychiatry in France for several years before serving as a visiting scholar at the Stanford Sleep Disorders Clinic and Research Center. He joined as faculty and Director of the Center for Narcolepsy in 1993. He was named Professor of Psychiatry in 2001. He has received numerous awards for his work and is a member of both the National Academies of Sciences and Medicine.

Dr. Mignot positionally cloned a mutation in the dog causing narcolepsy (hypocretin receptor 2) and discovered that narcolepsy, affecting 1/2000 people, is caused by an immune-mediated destruction of 70,000 hypocretin/orexin neurons in the hypothalamus, also revealing hypocretins as a novel critical sleep-regulatory pathway. Most of his current research focuses on the neurobiology, genetics and immunology of narcolepsy, with indirect interest in the neuroimmunology of other brain disorders such as autoimmune encephalitis or neurological paraneoplastic syndromes.

His laboratory also uses state of the art human genetics, proteomics and immunology techniques, such as genome-wide association, exome or whole genome sequencing or large scale proteomics in the study of human sleep and sleep disorders, with parallel studies in animal models. His laboratory is lastly interested in web-based assessments of sleep disorders, and conducts deep learning-based processing of polysomnography (PSG), and outcome research.

Professional Summary

Professional Education
  • Fellowship: Stanford University - Dept of Psychiatry (1996) CA
  • Board Certification: American Board of Sleep Medicine, Sleep Medicine (1990)
  • Residency: Necker Enfants Malades Hospital (1989) France
  • Medical Education: University Of Paris (1985) France
  • Internship: Necker Enfants Malades Hospital (1984) France

Honors & Awards
  • Elected member, Association of American Physicians (2011)
  • Elected member, Institute of Medicine (2006)
  • Elected member, National Academy Of Sciences (2012)
  • Foster Elting Bennett Memorial Lecture Award, American Neurological Association (2004)
  • Investigator Award, Howard Hughes Medical Institute (2002-2010)
  • Javits Award, National Institute of Neurological Disease and Stroke (NINDS) (1999)
  • Neuroscience of Brain Disorders Award, McKnight Foundation (2002)
  • Outstanding Scientific Achievement Award, Sleep Research Society (2006)
  • W. Alden Spencer Award, College of Physicians and Surgeons of Columbia University (2004)
  • William C Dement Academic Achievement Award, American Academy of Sleep Medicine (2000)

Administrative Appointments
  • Director, Center For Narcolepsy (1989 - Present)
  • Director, Center For Sleep Sciences and Medicine (2010 - 2019)


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Practice Locations

Sleep Medicine Center Redwood City, CA
Redwood City, CA

450 Broadway Street, Pavilion B, 2nd Floor, MC 5730

Redwood City , CA 94063

(650) 723-6601

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Patient Ratings

(17 Ratings)

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Patient Reviews

(18 reviews)

Dr. Mignot is a wonderful human being who is honest and genuine. I don't know any other PWN, but I will recommend Dr. Mignot should that ever change.
I was happy with this visit.
I had an incredible time with Dr. Mignot. I was so impressed with how kind, patient, & informative he was. He spent SO much time with me, listening & answering questions to be sure I understood & was comfortable with everything we discussed.
Nothing but amazing things to say about Dr. Mignot... he is the REAL DEAL!
It doesn't get better! Totally excellent.
Dr. Mignot was extremely personable and professional in this visit. Having medical professionals in the room for such a through consultation was extremely beneficial and surprisingly included a lot of time for discussion.
I was so impressed with Dr. Mignot. I feel blessed to be his patient.
My doctors were the most pleasant and understanding caregivers I ever met. Could not have asked for better caregivers.
We traveled from the East Coast & one review had said the dr. we were seeing had no bedside manner. Nothing could be further from the truth! He was fantastic.
I would highly recommend Dr. Mignot and Stanford Sleep Center to anyone! Dr. Mignot/excellent! Wow!
I look forward to my appointments because I know my physician is a pleasant to converse with about my concerns and questions.
In 32 years of my sleep problems Dr. Mignot had a diagnosis and understood the complexity of my sleep problems. His compassion and care about me. Listening... RELEVANT questions was a big BLESSING!
We had a very good & thorough visit with onsite resident and dr. Mignot. Current issues were discussed and solutions & advice provided.
Dr. Mignot was incredibly helpful, very knowledgeable, and especially great at tailoring his advise/evaluation/treatment specifically for an individual's particular situation. Also, the amount of time spent with Dr. Mignot was excellent - much longer than expected, very generous of him, and much appreciated.
Dr. Mignot is the best!
Dr. Mignot has saved my life & I will never be able to thank him enough.
My provider has literally changed my life by providing the most excellent care I have ever encountered.
Very thorough.

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