The Cancer Genetics Clinic is part of Stanford’s
Cancer Center, a National Cancer Institute-designated center
offering genetic counseling and testing for individuals concerned with
the risk of an inherited cancer predisposition. The clinic staff
includes medical oncologists, genetic counselors, and geneticists.
Genes are what determine your traits, such as eye color and blood
type. They are contained on our chromosomes, which normally number 46
total (23 pairs) in each cell of our body. There are an estimated
30,000 to 35,000 different genes contained on these chromosomes. Genes
are made of DNA. DNA stands for deoxyribonucleic acid. DNA is made up
of base pairs that provide the codes for making proteins. So,
ultimately, a gene, or a section of our DNA, makes a protein. There is
also DNA located in between genes, which does not code for anything in
particular, but simply serves as "spacer." Therefore, not
all of the DNA in our cells is used to make protein products.
Genes are found in pairs, just as the chromosomes are. One member of
each gene pair is inherited from our mother, while the corresponding
member of the gene pair is inherited from our father. Genes are
expressed in different ways. For some genes, both copies are needed in
order for the protein they make to work properly in the body. For
other genes, only one copy is necessary. For yet other genes, how the
gene works depends on which parent it was inherited from.
Genes that are present on the first 22 pairs of chromosomes are said
to be autosomal.
This means that both males and females are equally likely to have
these genes. The last pair of chromosomes determines gender. Males
have one X and one Y chromosome, while females have two X chromosomes.
Therefore, women do not have any of the genes present on the Y, and
men have only one copy of genes on the X.
The idea of inheritance was first described by an Austrian monk
whose name was Gregor Mendel. Mendel performed experiments on garden
peas to determine patterns of inheritance. These basic patterns are
sometimes called "Mendelian" or "traditional"
inheritance. The basic patterns of inheritance are: autosomal
dominant, autosomal recessive, and X-linked inheritance.
There are many different single gene defects that require clinical
care by a physician or other healthcare professional. Listed in the
directory below are some, for which we have provided a brief overview.
This video explains how Stanford doctors use the genetics of individual tumors to design a personalized treatment for best results and to guide development of new treatments.
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
See the BRCA
Decision Tool which guides the management of cancer risks for
BRCA1 and BRCA2 mutation carriers.
Please fax the Medical Record Release Form to your new patient
coordinator. The medical release form is an authorization form for
external facilities to release medical records to Stanford Health Care
(formerly Stanford Hospital & Clinics).
Stanford Health Care (formerly Stanford Hospital & Clinics)
provides comprehensive services to refer and track patients, as well
as provides the latest information and news for physicians and office
staff. For help with all referral needs and questions visit Referring Physicians.
HOW TO REFER
Fax a referral form with supporting documentation to 650-320-9443.
Please note, though this form is from Stanford Health Care (formerly
Stanford Hospital & Clinics), it is also used for all Cancer
Track your patients' progress and communicate with Stanford providers