John Clarke

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Biography

Dr. John Clarke recently joined the Gastroenterology & Hepatology Division at Stanford University as Director of the Esophageal Program. He previously spent 17 years in Baltimore, including 9 years on the faculty at Johns Hopkins University where he was an Associate Professor and at various times Director of Esophageal Motility, Director of Gastrointestinal Motility, Clinical Director of the Johns Hopkins Center for Neurogastroenterology, and Clinical Director of the Gastroenterology & Hepatology Division at Johns Hopkins Bayview Medical Center.

His career has combined research, education and clinical care. His clinical areas of expertise include achalasia, dysphagia, eosinophilic esophagitis, esophageal dysmotility, gastroesophageal reflux disease, gastroparesis, GI-manifestations of scleroderma and GI dysmotility. While at Johns Hopkins University, he was inducted into The Miller-Coulson Academy for Clinical Excellence, an institutional honor society for master clinicians at the time limited to 50 members across the entire university.

From an education standpoint, he has lectured in over a dozen countries, authored over 25 textbook chapters and serves on the educational affairs committee of the American College of Gastroenterology. He has also won several major teaching awards, including The Johns Hopkins University Alumni Association Award for Excellence in Teaching, given to one faculty member per year in the entire School of Medicine.

His research has focused on optimization and characterization of diagnostic studies to evaluate motility disorders, as well the relationship between therapeutic endoscopic techniques and treatment of motility disorders. He was an investigator on the NIH Gastroparesis Consortium and is also a former recipient of the AGA Don Castell Award.

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Professional Summary

Professional Education

Board Certification: American Board of Internal Medicine, Gastroenterology (2007)
Fellowship: Johns Hopkins University Dept of Gastroenterology (2007) MD
Board Certification: American Board of Internal Medicine, Internal Medicine (2002)

Residency: Johns Hopkins Hospital Internal Medicine Residency (2002) MD

Medical Education: Columbia University College of Physicians and Surgeons (1999) NY

Honors & Awards

Award for Excellence in Teaching, John Hopkins University Alumni Association (2015)

Administrative Appointments

Director, Esophageal Program, Stanford Medicine (2016 - Present)

Publications

Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery: A pilot study in a live porcine model
Ko, C.-W., Shin, E. J., Buscaglia, J. M., Clarke, J. O., Magno, P., Giday, S. A., … Kantsevoy, S. V. (2007). Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery: A pilot study in a live porcine model. ENDOSCOPY, 39(10), 849–53.
D-1- and D-2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro
Wong, A. C., Shetreat, M. E., Clarke, J. O., & Rayport, S. (1999). D-1- and D-2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro. NEUROSCIENCE, 89(1), 221–233.
Is blood the ideal submucosal cushioning agent? A comparative study in a porcine model
Giday, S. A., Magno, P., Buscaglia, J. M., Canto, M. I., Ko, C.-W., Shin, E. J., … Kantsevoy, S. V. (2006). Is blood the ideal submucosal cushioning agent? A comparative study in a porcine model. ENDOSCOPY, 38(12), 1230–1234.

Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis.
Parkman, H. P., Hallinan, E. K., Hasler, W. L., Farrugia, G., Koch, K. L., Calles, J., … HAMILTON, F. (2016). Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis. Neurogastroenterology and Motility .

Clinical and pH study characteristics in reflux patients with and without ineffective oesophageal motility (IEM).
Triadafilopoulos, G., Tandon, A., Shetler, K. P., & Clarke, J. (2016). Clinical and pH study characteristics in reflux patients with and without ineffective oesophageal motility (IEM). BMJ Open Gastroenterology, 3(1).

Pyloric Therapies for Gastroparesis.
Ahuja, N. K., & Clarke, J. O. (2017). Pyloric Therapies for Gastroparesis. Current Treatment Options in Gastroenterology.

The Role of Impedance Planimetry in the Evaluation of Esophageal Disorders.
Ahuja, N. K., & Clarke, J. O. (2017). The Role of Impedance Planimetry in the Evaluation of Esophageal Disorders. Current Gastroenterology Reports, 19(2), 7-?

Three-Dimensional Anorectal Manometry Enhances Diagnostic Gain by Detecting Sphincter Defects and Puborectalis Pressure.
Raja, S., Okeke, F. C., Stein, E. M., Dhalla, S., Nandwani, M., Lynch, K. L., … Clarke, J. O. (2017). Three-Dimensional Anorectal Manometry Enhances Diagnostic Gain by Detecting Sphincter Defects and Puborectalis Pressure. Digestive Diseases and Sciences.

What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center.
Okeke, F. C., Raja, S., Lynch, K. L., Dhalla, S., Nandwani, M., Stein, E. M., … Clarke, J. O. (2017). What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center. Neurogastroenterology and Motility , 29(6).

Esophageal distensibility measurement: impact on clinical management and procedure length.
Ahuja, N. K., Agnihotri, A., Lynch, K. L., Hoo-Fatt, D., Onyimba, F., McKnight, M., … Clarke, J. O. (2017). Esophageal distensibility measurement: impact on clinical management and procedure length. Diseases of the Esophagus , 30(8), 1–8.

The Changing Impact of Gastroesophageal Reflux Disease in Clinical Practice: An Updated Study
Akst, L. M., Haque, O. J., Clarke, J. O., Hillel, A. T., Best, S. R. A., & Altman, K. W. (2017). The Changing Impact of Gastroesophageal Reflux Disease in Clinical Practice: An Updated Study. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 126(3), 229–35.

Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing
Parkman, H. P., Hallinan, E. K., Hasler, W. L., Farrugia, G., Koch, K. L., Nguyen, L., … HAMILTON, F. (2017). Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing. NEUROGASTROENTEROLOGY AND MOTILITY, 29(4).

Learning Curve for PerOral Endoscopic Myotomy Deciphered: a Comprehensive Analysis Using Two Different Methodologies
El Zein, M. H., Kumbhari, V., Saxena, P., Kamal, A., Ngamruengphong, S., Besharati, S., … Khashab, M. (2015). Learning Curve for PerOral Endoscopic Myotomy Deciphered: a Comprehensive Analysis Using Two Different Methodologies. GASTROINTESTINAL ENDOSCOPY, 81(5), AB167–AB167.

Intraoperative measurement of esophagogastric junction cross-sectional area by impedance planimetry correlates with clinical outcomes of peroral endoscopic myotomy for achalasia: a multicenter study
Ngamruengphong, S., von Rahden, B. H. A., Filser, J., Tyberg, A., Desai, A., Sharaiha, R. Z., … Khashab, M. A. (2016). Intraoperative measurement of esophagogastric junction cross-sectional area by impedance planimetry correlates with clinical outcomes of peroral endoscopic myotomy for achalasia: a multicenter study. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 30(7), 2886–94.

Comprehensive analysis of efficacy and safety of peroral endoscopic myotomy performed by a gastroenterologist in the endoscopy unit: a single-center experience
Khashab, M. A., El Zein, M., Kumbhari, V., Besharati, S., Ngamruengphong, S., Messallam, A., … Clarke, J. O. (2016). Comprehensive analysis of efficacy and safety of peroral endoscopic myotomy performed by a gastroenterologist in the endoscopy unit: a single-center experience. GASTROINTESTINAL ENDOSCOPY, 83(1), 117–25.

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis
Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., … Clarke, J. O. (2016). Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis. DISEASES OF THE ESOPHAGUS, 29(2), 174–78.

Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis
Pasricha, P. J., Yates, K. P., Nguyen, L., Clarke, J., Abell, T. L., Farrugia, G., … Parkman, H. P. (2015). Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis. GASTROENTEROLOGY, 149(7), 1762-?

Refractory gastroparesis can be successfully managed with endoscopic transpyloric stent placement and fixation (with video)
Khashab, M. A., Besharati, S., Ngamruengphong, S., Kumbhari, V., El Zein, M., Stein, E. M., … Clarke, J. O. (2015). Refractory gastroparesis can be successfully managed with endoscopic transpyloric stent placement and fixation (with video). GASTROINTESTINAL ENDOSCOPY, 82(6), 1106–9.

Comprehensive Radionuclide Esophagogastrointestinal Transit Study: Methodology, Reference Values, and Initial Clinical Experience
Antoniou, A. J., Raja, S., El-Khouli, R., Mena, E., Lodge, M. A., Wahl, R. L., … Ziessman, H. A. (2015). Comprehensive Radionuclide Esophagogastrointestinal Transit Study: Methodology, Reference Values, and Initial Clinical Experience. JOURNAL OF NUCLEAR MEDICINE, 56(5), 721–27.

Small Intestinal Transit Time Is Delayed in Small Intestinal Bacterial Overgrowth
Roland, B. C., Ciarleglio, M. M., Clarke, J. O., Semler, J. R., Tomakin, E., Mullin, G. E., & Pasricha, P. J. (2015). Small Intestinal Transit Time Is Delayed in Small Intestinal Bacterial Overgrowth. JOURNAL OF CLINICAL GASTROENTEROLOGY, 49(7), 571–76.

High-resolution anorectal manometry and dynamic pelvic magnetic resonance imaging are complementary technologies
Jodorkovsky, D., Macura, K. J., Gearhart, S. L., Dunbar, K. B., Stein, E. M., & Clarke, J. O. (2015). High-resolution anorectal manometry and dynamic pelvic magnetic resonance imaging are complementary technologies. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30(1), 71–74.

Upper Esophageal Sphincter Abnormalities Frequent Finding on High-resolution Esophageal Manometry and Associated With Poorer Treatment Response in Achalasia
Chavez, Y. H., Ciarleglio, M. M., Clarke, J. O., Nandwani, M., Stein, E., & Roland, B. C. (2015). Upper Esophageal Sphincter Abnormalities Frequent Finding on High-resolution Esophageal Manometry and Associated With Poorer Treatment Response in Achalasia. JOURNAL OF CLINICAL GASTROENTEROLOGY, 49(1), 17–23.

Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth.
Chedid, V., Dhalla, S., Clarke, J. O., Roland, B. C., Dunbar, K. B., Koh, J., … Mullin, G. E. (2014). Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Global Advances in Health and Medicine, 3(3), 16–24.

Low Ileocecal Valve Pressure Is Significantly Associated with Small Intestinal Bacterial Overgrowth (SIBO)
Roland, B. C., Ciarleglio, M. M., Clarke, J. O., Semler, J. R., Tomakin, E., Mullin, G. E., & Pasricha, P. J. (2014). Low Ileocecal Valve Pressure Is Significantly Associated with Small Intestinal Bacterial Overgrowth (SIBO). DIGESTIVE DISEASES AND SCIENCES, 59(6), 1269–77.

Domperidone for delayed gastric emptying in lung transplant recipients with and without gastroesophageal reflux
Lidor, A. O., Ensor, C. R., Sheer, A. J., Orens, J. B., Clarke, J. O., & McDyer, J. F. (2014). Domperidone for delayed gastric emptying in lung transplant recipients with and without gastroesophageal reflux. PROGRESS IN TRANSPLANTATION, 24(1), 27–32.

Multichannel Intraluminal Impedance-pH Testing Is Clinically Useful in the Management of Patients with Gastroesophageal Reflux Symptoms
Jodorkovsky, D., Price, J. C., Kim, B., Dhalla, S., Stein, E. M., & Clarke, J. O. (2014). Multichannel Intraluminal Impedance-pH Testing Is Clinically Useful in the Management of Patients with Gastroesophageal Reflux Symptoms. DIGESTIVE DISEASES AND SCIENCES, 59(8), 1817–22.

Peroral endoscopic myotomy as a platform for the treatment of spastic esophageal disorders refractory to medical therapy (with video)
Khashab, M. A., Saxena, P., Kumbhari, V., Nandwani, M., Roland, B. C., Stein, E., … Pasricha, P. J. (2014). Peroral endoscopic myotomy as a platform for the treatment of spastic esophageal disorders refractory to medical therapy (with video). GASTROINTESTINAL ENDOSCOPY, 79(1), 136–39.

Jet injection of dyed saline facilitates efficient peroral endoscopic myotomy
Khashab, M. A., Messallam, A. A., Saxena, P., Kumbhari, V., Ricourt, E., Aguila, G., … Clarke, J. O. (2014). Jet injection of dyed saline facilitates efficient peroral endoscopic myotomy. ENDOSCOPY, 46(4), 298–301.

Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis
Clarke, J. O., Sharaiha, R. Z., Valeshabad, A. K., Lee, L. A., Kalloo, A. N., & Khashab, M. A. (2013). Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis. ENDOSCOPY, 45, E189–E190.

Biofeedback Therapy for Defecatory Dysfunction "Real Life" Experience
Jodorkovsky, D., Dunbar, K. B., Gearhart, S. L., Stein, E. M., & Clarke, J. O. (2013). Biofeedback Therapy for Defecatory Dysfunction "Real Life" Experience. JOURNAL OF CLINICAL GASTROENTEROLOGY, 47(3), 252–55.

The Relationship Between Depressive Symptoms and Voice Handicap Index Scores in Laryngopharyngeal Reflux
Elam, J. C., Ishman, S. L., Dunbar, K. B., Clarke, J. O., & Gourin, C. G. (2010). The Relationship Between Depressive Symptoms and Voice Handicap Index Scores in Laryngopharyngeal Reflux. LARYNGOSCOPE, 120(9), 1900–1903.

Enhanced diagnostic yield with prolonged small bowel transit time during capsule endoscopy.
Buscaglia, J. M., Kapoor, S., Clarke, J. O., Bucobo, J. C., Giday, S. A., Magno, P., … Mullin, G. E. (2008). Enhanced diagnostic yield with prolonged small bowel transit time during capsule endoscopy. International Journal of Medical Sciences, 5(6), 303–8.

Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems
Mehta, B. K., Franks, J., Cai, G., Toledo, D., Wood, T. A., Archambault, K. A., … Whitfield, M. L. (2017). Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems. ARTHRITIS & RHEUMATOLOGY. WILEY.

Aprepitant for Symptoms of Gastroparesis and Related Disorders: The APRON Randomized Clinical Trial
Pasricha, P. J., Yates, K., Sarosiek, I., McCallum, R., Clarke, J., Nguyen, L., … Parkman, H. (2016). Aprepitant for Symptoms of Gastroparesis and Related Disorders: The APRON Randomized Clinical Trial. AMERICAN JOURNAL OF GASTROENTEROLOGY. NATURE PUBLISHING GROUP.

Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders
Pasricha, P. J., Yates, K. P., Sarosiek, I., McCallum, R. W., Abell, T. L., Koch, K. L., … Parkman, H. P. (2018). Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders. GASTROENTEROLOGY, 154(1), 65-+.

Baclofen and gastroesophageal reflux disease: seeing the forest through the trees.
Clarke, J. O., Fernandez-Becker, N. Q., Regalia, K. A., & Triadafilopoulos, G. (2018). Baclofen and gastroesophageal reflux disease: seeing the forest through the trees. Clinical and Translational Gastroenterology, 9(3), 137.

Advances in the diagnosis and classification of gastric and intestinal motility disorders
Keller, J., Bassotti, G., Clarke, J., Dinning, P., Fox, M., Grover, M., … Camilleri, M. (2018). Advances in the diagnosis and classification of gastric and intestinal motility disorders. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 15(5), 291–308.

The Effect of Race in Patients with Achalasia Diagnosed With High-Resolution Esophageal Manometry
Chedid, V., Rosenblatt, E., Gandhi, K. (K., Dhalla, S., Nandwani, M. C., Stein, E. M., & Clarke, J. O. (2018). The Effect of Race in Patients with Achalasia Diagnosed With High-Resolution Esophageal Manometry. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 355(2), 126–31.

A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality.
Zikos, T. A., Clarke, J. O., Triadafilopoulos, G., Regalia, K. A., Sonu, I. S., Fernandez-Becker, N. Q., … Nguyen, L. A. (2018). A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality. Digestive Diseases and Sciences.

REFRACTORY GASTROPARESIS: GASTRIC PERORAL ENDOSCOPIC MYOTOMY (G-POEM) VS. INTRAPYLORIC BOTULINUM TOXIN INJECTION
Parsa, N., Yang, J., Gutierrez, O. I. B., Moran, R., Sanaei, O., Fayad, L., … Khashab, M. A. (2018). REFRACTORY GASTROPARESIS: GASTRIC PERORAL ENDOSCOPIC MYOTOMY (G-POEM) VS. INTRAPYLORIC BOTULINUM TOXIN INJECTION. GASTROINTESTINAL ENDOSCOPY, 87(6), AB241–AB242.

Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms.
Triadafilopoulos, G., Zikos, T., Regalia, K., Sonu, I., Fernandez-Becker, N. Q., Nguyen, L., … Clarke, J. O. (2018). Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms. Digestive Diseases and Sciences.

Nonerosive reflux disease: clinical concepts.
Gyawali, C. P., Azagury, D. E., Chan, W. W., Chandramohan, S. M., Clarke, J. O., de Bortoli, N., … Wu, J. (2018). Nonerosive reflux disease: clinical concepts. Annals of the New York Academy of Sciences.

Indications and interpretation of esophageal function testing.
Gyawali, C. P., de Bortoli, N., Clarke, J., Marinelli, C., Tolone, S., Roman, S., & Savarino, E. (2018). Indications and interpretation of esophageal function testing. Annals of the New York Academy of Sciences.

Pyridostigmine for the treatment of gastrointestinal symptoms in systemic sclerosis.
Ahuja, N. K., Mische, L., Clarke, J. O., Wigley, F. M., & McMahan, Z. H. (2018). Pyridostigmine for the treatment of gastrointestinal symptoms in systemic sclerosis. Seminars in Arthritis and Rheumatism.

Patients with symptoms of delayed gastric emptying have a high prevalence of oesophageal dysmotility, irrespective of scintigraphic evidence of gastroparesis.
Triadafilopoulos, G., Nguyen, L., & Clarke, J. O. (2017). Patients with symptoms of delayed gastric emptying have a high prevalence of oesophageal dysmotility, irrespective of scintigraphic evidence of gastroparesis. BMJ Open Gastroenterology, 4(1), e000169.

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.
Hasler, W. L., May, K. P., Wilson, L. A., Van Natta, M., Parkman, H. P., Pasricha, P. J., … Hamilton, F. A. (2018). Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 30(2).

Learning curve for peroral endoscopic myotomy
El Zein, M., Kumbhari, V., Ngamruengphong, S., Carson, K. A., Stein, E., Tieu, A., … Khashab, M. A. (2016). Learning curve for peroral endoscopic myotomy. ENDOSCOPY INTERNATIONAL OPEN, 4(5), E577–E582.

Upper Esophageal Sphincter Abnormalities Are Strongly Predictive of Treatment Response in Patients with Achalasia
Mathews, S., Chavez, Y., Ciarleglio, M., Clarke, J., Stein, E., & Roland, B. C. (2013). Upper Esophageal Sphincter Abnormalities Are Strongly Predictive of Treatment Response in Patients with Achalasia. AMERICAN JOURNAL OF GASTROENTEROLOGY, 108, S1–S2.

The Added Diagnostic Value of Liquid Gastric Emptying Compared with Solid Emptying Alone
Ziessman, H. A., Chander, A., Clarke, J. O., Ramos, A., & Wahl, R. L. (2009). The Added Diagnostic Value of Liquid Gastric Emptying Compared with Solid Emptying Alone. JOURNAL OF NUCLEAR MEDICINE, 50(5), 726–31.

Endoscopic retrograde cholangiopancreatography, but not esophagogastroduodenoscopy or colonoscopy, significantly increases portal venous pressure: direct portal pressure measurements through endoscopic ultrasound-guided cannulation
Buscaglia, J. M., Shin, E. J., Clarke, J. O., Giday, S. A., Ko, C. W., Thuluvath, P. J., … Kantsevoy, S. V. (2008). Endoscopic retrograde cholangiopancreatography, but not esophagogastroduodenoscopy or colonoscopy, significantly increases portal venous pressure: direct portal pressure measurements through endoscopic ultrasound-guided cannulation. ENDOSCOPY, 40(8), 670–74.

EUS-guided submucosal implantation of a radiopaque marker: a simple and effective procedure to facilitate subsequent surgical and radiation therapy
Magno, P., Giday, S. A., Gabrielson, K. L., Shin, E. J., Clarke, J. O., Ko, C.-W., … Kantsevoy, S. V. (2008). EUS-guided submucosal implantation of a radiopaque marker: a simple and effective procedure to facilitate subsequent surgical and radiation therapy. GASTROINTESTINAL ENDOSCOPY, 67(7), 1147–52.

Severity of post-ERCP pancreatitis directly proportional to the invasiveness of endoscopic intervention: a pilot study in a canine model
Buscaglia, J. M., Simons, B. W., Prosser, B. J., Ruben, D. S., Giday, S. A., Magno, P., … Jagannath, S. B. (2008). Severity of post-ERCP pancreatitis directly proportional to the invasiveness of endoscopic intervention: a pilot study in a canine model. ENDOSCOPY, 40(6), 506–12.

How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center
Clarke, J. O., Giday, S. A., Magno, P., Shin, E. J., Buscaglia, J. M., Jagannath, S. B., & Mullin, G. E. (2008). How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center. GASTROINTESTINAL ENDOSCOPY, 68(2), 267–72.

Performance characteristics of the suspected blood indicator feature in capsule endoscopy according to indication for study
Buscaglia, J. M., Giday, S. A., Kantsevoy, S. V., Clarke, J. O., Magno, P., Yong, E., & Mullin, G. E. (2008). Performance characteristics of the suspected blood indicator feature in capsule endoscopy according to indication for study. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 6(3), 298–301.

EUS-guided portal vein catheterization: a promising novel approach for portal angiography and portal vein pressure measurements
Giday, S. A., Clarke, J. O., Buscaglia, J. M., Shin, E. J., Ko, C.-W., Magno, P., & Kantsevoy, S. V. (2008). EUS-guided portal vein catheterization: a promising novel approach for portal angiography and portal vein pressure measurements. GASTROINTESTINAL ENDOSCOPY, 67(2), 338–42.

Classifying esophageal motility by pressure topography characteristics: A study of 400 patients and 75 controls
Pandolfino, J. E., Ghosh, S. K., Rice, J., Clarke, J. O., Kwiatek, M. A., & Kahrilas, P. J. (2008). Classifying esophageal motility by pressure topography characteristics: A study of 400 patients and 75 controls. AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 27–37.

EUS-guided portal vein carbon dioxide angiography: a pilot study in a porcine model
Giday, S. A., Ko, C.-W., Clarke, J. O., Shin, E. J., Magno, P., Jagannath, S. B., … Kantsevoy, S. V. (2007). EUS-guided portal vein carbon dioxide angiography: a pilot study in a porcine model. GASTROINTESTINAL ENDOSCOPY, 66(4), 814–19.

Comparative study of endoscopic clips: duration of attachment at the site of clip application
Shin, E. J., Ko, C.-W., Magno, P., Giday, S. A., Clarke, J. O., Buscaglia, J. M., … Kantsevoy, S. V. (2007). Comparative study of endoscopic clips: duration of attachment at the site of clip application. GASTROINTESTINAL ENDOSCOPY, 66(4), 757–61.

EUS-guided angiography: a novel approach to diagnostic and therapeutic interventions in the vascular system
Magno, P., Ko, C.-W., Buscaglia, J. M., Giday, S. A., Jagannath, S. B., Clarke, J. O., … Kantsevoy, S. V. (2007). EUS-guided angiography: a novel approach to diagnostic and therapeutic interventions in the vascular system. GASTROINTESTINAL ENDOSCOPY, 66(3), 587–91.

Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls
Ghosh, S. K., Pandolfino, J. E., Rice, J., Clarke, J. O., Kwiatek, M., & Kahrilas, P. J. (2007). Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(4), G878–G885.

EUS-guided implantation of radiopaque marker into mediastinal and celiac lymph nodes is safe and effective
Magno, P., Giday, S. A., Gabrielson, K. L., Shin, E. J., Buscaglia, J. M., Clarke, J. O., … Kantsevoy, S. V. (2007). EUS-guided implantation of radiopaque marker into mediastinal and celiac lymph nodes is safe and effective. GASTROINTESTINAL ENDOSCOPY, 66(2), 387–92.

The utility of contrast-enhanced endoscopic ultrasound in monitoring ethanol-induced pancreatic tissue ablation: a pilot study in a porcine model
Giday, S. A., Magno, P., Gabrielson, K. L., Buscaglia, J. M., Canto, M. I., Ko, C. W., … Kantsevoy, S. V. (2007). The utility of contrast-enhanced endoscopic ultrasound in monitoring ethanol-induced pancreatic tissue ablation: a pilot study in a porcine model. ENDOSCOPY, 39(6), 525–29.

High-resolution manometry of the EGJ: An analysis of crural diaphragm function in GERD
Pandolfino, J. E., Kim, H., Ghosh, S. K., Clarke, J. O., Zhang, Q., & Kahrilas, P. J. (2007). High-resolution manometry of the EGJ: An analysis of crural diaphragm function in GERD. AMERICAN JOURNAL OF GASTROENTEROLOGY, 102(5), 1056–63.

An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model
Clarke, J. O., Jagannath, S. B., Kalloo, A. N., Long, V. R., Beitler, D. M., & Kantsevoy, S. V. (2007). An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model. ENDOSCOPY, 39(1), 72–76.

Clinical and manometric characteristics of patients with oesophagogastric outflow obstruction: towards a new classification.
Triadafilopoulos, G., & Clarke, J. O. (2018). Clinical and manometric characteristics of patients with oesophagogastric outflow obstruction: towards a new classification. BMJ Open Gastroenterology, 5(1), e000210.

Clinical and pH study characteristics in reflux patients with and without ineffective oesophageal motility (IEM)
Triadafilopoulos, G., Tandon, A., Shetler, K. P., & Clarke, J. (2016). Clinical and pH study characteristics in reflux patients with and without ineffective oesophageal motility (IEM). BMJ OPEN GASTROENTEROLOGY, 3(1).

Incorporating Advanced Practice Providers into Gastroenterology Practice.
Nandwani, M. C., & Clarke, J. O. (2018). Incorporating Advanced Practice Providers into Gastroenterology Practice. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association.

Gastrointestinal Involvement in Systemic Sclerosis An Update
Miller, J. B., Gandhi, N., Clarke, J., & McMahan, Z. (2018). Gastrointestinal Involvement in Systemic Sclerosis An Update. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 24(6), 328–37.

Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems
Mehta, B. K., Franks, J., Wang, Y., Cai, G., Toledo, D. M., Wood, T. A., … Whitfield, M. L. (2018). Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems. ARTHRITIS & RHEUMATOLOGY. WILEY.

Identification of Risk Factors for Gastric Antral Vascular Ectasia (GAVE) Among Systemic Sclerosis Patients
Serling-Boyd, N., Li, S., Fiorentino, D., Becker, L., Fernandez-Becker, N., Clarke, J., & Chung, L. (2018). Identification of Risk Factors for Gastric Antral Vascular Ectasia (GAVE) Among Systemic Sclerosis Patients. ARTHRITIS & RHEUMATOLOGY, 70.

Helping Patients with Gastroparesis.
Onyimba, F. U., & Clarke, J. O. (2019). Helping Patients with Gastroparesis. The Medical Clinics of North America, 103(1), 71–87.

Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life.
Parkman, H. P., Wilson, L. A., Hasler, W. L., McCallum, R. W., Sarosiek, I., Koch, K. L., … Pasricha, P. J. (2019). Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life. Digestive Diseases and Sciences.

High Prevalence of Slow Transit Constipation in Patients With Gastroparesis.
Zikos, T. A., Kamal, A. N., Neshatian, L., Triadafilopoulos, G., Clarke, J. O., Nandwani, M., & Nguyen, L. A. (2019). High Prevalence of Slow Transit Constipation in Patients With Gastroparesis. Journal of Neurogastroenterology and Motility.

Under Pressure: Do Volume-Based Measurements Define Rectal Hyposensitivity in Clinical Practice?
Kamal, A. N., Garcia, P., & Clarke, J. O. (2019). Under Pressure: Do Volume-Based Measurements Define Rectal Hyposensitivity in Clinical Practice? Digestive Diseases and Sciences.

Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium.
Gyawali, C. P., Sifrim, D., Carlson, D. A., Hawn, M., Katzka, D. A., Pandolfino, J. E., … Triadafilopoulos, G. (2019). Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e13584.

Murky Waters for Diagnosis of Gastroparesis.
Kunkel, D. C., & Clarke, J. O. (2019). Murky Waters for Diagnosis of Gastroparesis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association.

Esophagogastroduodenoscopy and Esophageal Involvement in Patients With Pemphigus Vulgaris
Ozeki, K., Zikos, T. A., Clarke, J., & Sonu, I. (2018). Esophagogastroduodenoscopy and Esophageal Involvement in Patients With Pemphigus Vulgaris. AMERICAN JOURNAL OF GASTROENTEROLOGY, 113, S177.

High Prevalence of Slow Transit Constipation in Patients With Gastroparesis
Zikos, T. A., Kamal, A. N., Neshatian, L., Triadafilopoulos, G., Clarke, J. O., Nandwani, M., & Nguyen, L. A. (2019). High Prevalence of Slow Transit Constipation in Patients With Gastroparesis. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, 25(2), 267–75.

Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms
Triadafilopoulos, G., Zikos, T., Regalia, K., Sonu, I., Fernandez-Becker, N. Q., Nguyen, L., … Clarke, J. O. (2018). Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms. DIGESTIVE DISEASES AND SCIENCES, 63(10), 2673–80.

A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality
Zikos, T. A., Clarke, J. O., Triadafilopoulos, G., Regalia, K. A., Sonu, I. S., Fernandez-Becker, N. Q., … Nguyen, L. A. (2018). A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality. DIGESTIVE DISEASES AND SCIENCES, 63(12), 3417–24.

Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis
Hasler, W. L., Wilson, L. A., Nguyen, L. A., Snape, W. J., Abell, T. L., Koch, K. L., … Yates, K. (2019). Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(7), 1285-+.

Gastric per-oral endoscopic myotomy: Current status and future directions
Podboy, A., Hwang, J. H., Nguyen, L. A., Garcia, P., Zikos, T. A., Kamal, A., … Clarke, J. O. (2019). Gastric per-oral endoscopic myotomy: Current status and future directions. WORLD JOURNAL OF GASTROENTEROLOGY, 25(21), 2581–90.

Gastric per-oral endoscopic myotomy: Current status and future directions.
Podboy, A., Hwang, J. H., Nguyen, L. A., Garcia, P., Zikos, T. A., Kamal, A., … Clarke, J. O. (2019). Gastric per-oral endoscopic myotomy: Current status and future directions. World Journal of Gastroenterology, 25(21), 2581–2590.

PER-ORAL ENDOSCOPIC MYOTOMY HAS SIMILAR EFFICACY COMPARED TO LAPAROSCOPIC HELLER MYOTOMY AFTER 4 YEARS: A SINGLE CENTER EXPERIENCE
Podboy, A. J., Hwang, J. H., Rivas, H., Azagury, D., Hawn, M. T., Kamal, A., … Clarke, J. O. (2019). PER-ORAL ENDOSCOPIC MYOTOMY HAS SIMILAR EFFICACY COMPARED TO LAPAROSCOPIC HELLER MYOTOMY AFTER 4 YEARS: A SINGLE CENTER EXPERIENCE. GASTROINTESTINAL ENDOSCOPY, 89(6), AB201–AB202.

Baclofen and gastroesophageal reflux disease: seeing the forest through the trees
Clarke, J. O., Fernandez-Becker, N. Q., Regalia, K. A., & Triadafilopoulos, G. (2018). Baclofen and gastroesophageal reflux disease: seeing the forest through the trees. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 9.

Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life
Parkman, H. P., Wilson, L. A., Hasler, W. L., McCallum, R. W., Sarosiek, I., Koch, K. L., … Pasricha, P. J. (2019). Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life. DIGESTIVE DISEASES AND SCIENCES, 64(8), 2242–55.

Murky Waters for Diagnosis of Gastroparesis
Kunkel, D. C., & Clarke, J. O. (2019). Murky Waters for Diagnosis of Gastroparesis. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(9), 1724–25.

Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium
Gyawali, C. P., Sifrim, D., Carlson, D. A., Hawn, M., Katzka, D. A., Pandolfino, J. E., … Triadafilopoulos, G. (2019). Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium. NEUROGASTROENTEROLOGY AND MOTILITY, 31(9).

Esophagogastroduodenoscopy and Esophageal Involvement in Patients with Pemphigus Vulgaris.
Ozeki, K. A., Zikos, T. A., Clarke, J. O., & Sonu, I. (2019). Esophagogastroduodenoscopy and Esophageal Involvement in Patients with Pemphigus Vulgaris. Dysphagia.

Impact of nurse practitioner navigation on access to care for patients with refractory gastroesophageal reflux disease.
Nandwani, M., Clarke, J. O., Kuriakose, C., & Stevenson, E. (2019). Impact of nurse practitioner navigation on access to care for patients with refractory gastroesophageal reflux disease. Journal of the American Association of Nurse Practitioners.

Reduction in Hospitalizations for Esophageal Reflux in a Decade with Minimal Increases in Other Functional and Motor Disorders.
Zikos, T. A., Hendler, S., Clarke, J. O., Triadafilopoulos, G., Nguyen, L., & Limketkai, B. N. (2019). Reduction in Hospitalizations for Esophageal Reflux in a Decade with Minimal Increases in Other Functional and Motor Disorders. Digestive Diseases and Sciences.

Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis.
Parkman, H. P., Wilson, L. A., Farrugia, G., Koch, K. L., Hasler, W. L., Nguyen, L. A., … Pasricha, P. J. (2019). Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis. The American Journal of Gastroenterology.

Ninety-Six Hour Wireless Esophageal pH Study in Patients with GERD Shows that Restrictive Diet Reduces Esophageal Acid Exposure.
Triadafilopoulos, G., Korzilius, J. W., Zikos, T., Sonu, I., Fernandez-Becker, N. Q., Nguyen, L., & Clarke, J. O. (2019). Ninety-Six Hour Wireless Esophageal pH Study in Patients with GERD Shows that Restrictive Diet Reduces Esophageal Acid Exposure. Digestive Diseases and Sciences.

Incorporating Advanced Practice Providers Into Gastroenterology Practice
Nandwani, M. C. R., & Clarke, J. O. (2019). Incorporating Advanced Practice Providers Into Gastroenterology Practice. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(3), 365–69.

Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis.
Gottfried-Blackmore, A., Adler, E. P., Fernandez-Becker, N., Clarke, J., Habtezion, A., & Nguyen, L. (2019). Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e13769.

Changes in high-resolution manometric diagnosis over time: implications for clinical decision-making.
Triadafilopoulos, G., Kamal, A., Zikos, T., Nguyen, L., & Clarke, J. O. (2020). Changes in high-resolution manometric diagnosis over time: implications for clinical decision-making. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus.

Development of a Preliminary Question Prompt List as a Communication Tool for Adults With Gastroesophageal Reflux Disease: A Modified Delphi Study.
Kamal, A., Katzka, D. A., Achkar, E., Carlson, D., Clarke, J., Fass, R., … Triadafilopoulos, G. (2020). Development of a Preliminary Question Prompt List as a Communication Tool for Adults With Gastroesophageal Reflux Disease: A Modified Delphi Study. Journal of Clinical Gastroenterology.

Esophagogastric Junction Outflow Obstruction: Current Approach to Diagnosis and Management.
Zikos, T. A., Triadafilopoulos, G., & Clarke, J. O. (2020). Esophagogastric Junction Outflow Obstruction: Current Approach to Diagnosis and Management. Current Gastroenterology Reports, 22(2), 9.

Linaclotide for the Treatment of Gastrointestinal Symptoms in Systemic Sclerosis
Dein, E., Clarke, J., Wigley, F., & McMahan, Z. (2019). Linaclotide for the Treatment of Gastrointestinal Symptoms in Systemic Sclerosis. ARTHRITIS & RHEUMATOLOGY, 71.

Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity.
Nguyen, L., Wilson, L. A., Miriel, L., Pasricha, P. J., Kuo, B., Hasler, W. L., … Abell, T. L. (2020). Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e13810.

New Developments in the Diagnosis and Management of Gastroesophageal Reflux.
Jiang, Y., & Clarke, J. O. (2020). New Developments in the Diagnosis and Management of Gastroesophageal Reflux. Current Treatment Options in Gastroenterology.

Motility Abnormalities Identified by Wireless Motility Capsule in Postural Orthostatic Tachycardia Syndrome
Zikos, T. A., Zhou, W., Clarke, J. O., Nguyen, L. A., & Neshatian, L. (2019). Motility Abnormalities Identified by Wireless Motility Capsule in Postural Orthostatic Tachycardia Syndrome. AMERICAN JOURNAL OF GASTROENTEROLOGY. LIPPINCOTT WILLIAMS & WILKINS.

Long-term outcomes of per-oral endoscopic myotomy compared to laparoscopic Heller myotomy for achalasia: a single-center experience.
Podboy, A. J., Hwang, J. H., Rivas, H., Azagury, D., Hawn, M., Lau, J., … Clarke, J. O. (2020). Long-term outcomes of per-oral endoscopic myotomy compared to laparoscopic Heller myotomy for achalasia: a single-center experience. Surgical Endoscopy.

Marijuana, Ondansetron, and Promethazine Are Perceived as Most Effective Treatments for Gastrointestinal Nausea.
Zikos, T. A., Nguyen, L., Kamal, A., Fernandez-Becker, N., Regalia, K., Nandwani, M., … Clarke, J. O. (2020). Marijuana, Ondansetron, and Promethazine Are Perceived as Most Effective Treatments for Gastrointestinal Nausea. Digestive Diseases and Sciences.

Clinical and immunomodulatory effects of transcutaneous vagal nerve stimulation for idiopathic gastroparesis
Gottfried-Blackmore, A., Namkoong, H., Adler, E. P., Fernandez-Becker, N., Clarke, J., Habtezion, A., & Nguyen, L. (2020). Clinical and immunomodulatory effects of transcutaneous vagal nerve stimulation for idiopathic gastroparesis. NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.

The role of ambulatory 24-hour esophageal manometry in clinical practice.
Kamal, A. N., Clarke, J. O., Oors, J. M., & Bredenoord, A. J. (2020). The role of ambulatory 24-hour esophageal manometry in clinical practice. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e13861.

Diagnosis of gastroesophageal reflux: an update on current and emerging modalities.
Ang, D., Lee, Y.-Y. Y., Clarke, J. O., Lynch, K., Guillaume, A., Onyimba, F., … Gyawali, C. P. (2020). Diagnosis of gastroesophageal reflux: an update on current and emerging modalities. Annals of the New York Academy of Sciences.

How to approach esophagogastric junction outflow obstruction?
Patcharatrakul, T., Alkaddour, A., Pitisuttithum, P., Jangsirikul, S., Vega, K. J., Clarke, J. O., & Gonlachanvit, S. (2020). How to approach esophagogastric junction outflow obstruction? Annals of the New York Academy of Sciences.

Mucosal impedance for esophageal disease: evaluating the evidence.
Clarke, J. O., Ahuja, N. K., Chan, W. W., Gyawali, C. P., Horsley-Silva, J. L., Kamal, A. N., … Xiao, Y. (2020). Mucosal impedance for esophageal disease: evaluating the evidence. Annals of the New York Academy of Sciences.

Non-acid Reflux: When It Matters and Approach to Management.
Zikos, T. A., & Clarke, J. O. (2020). Non-acid Reflux: When It Matters and Approach to Management. Current Gastroenterology Reports, 22(9), 43.

Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view.
Lottrup, C., Khan, A., Rangan, V., & Clarke, J. O. (2020). Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view. Annals of the New York Academy of Sciences.

Gastric per-oral endoscopic myotomy for severe post-lung transplant gastroparesis: A single-center experience.
Podboy, A. J., Clarke, J. O., Nguyen, L. A., Mooney, J. J., Dhillon, G. S., & Hwang, J. H. (2020). Gastric per-oral endoscopic myotomy for severe post-lung transplant gastroparesis: A single-center experience. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation.

Use of the Functional Lumen Imaging Probe in Clinical Esophagology.
Savarino, E., di Pietro, M., Bredenoord, A. J., Carlson, D. A., Clarke, J. O., Khan, A., … Gyawali, C. P. (2020). Use of the Functional Lumen Imaging Probe in Clinical Esophagology. The American Journal of Gastroenterology.

The Role of Symptom Association Analysis in Gastroesophageal Reflux Testing.
Kamal, A. N., Clarke, J. O., Oors, J. M., Smout, A. J., & Bredenoord, A. J. (2020). The Role of Symptom Association Analysis in Gastroesophageal Reflux Testing. The American Journal of Gastroenterology.

The functional lumen imaging probe in gastrointestinal disorders: the past, present, and future.
Clarke, J. O., Ahuja, N. K., Fernandez-Becker, N. Q., Gregersen, H., Kamal, A. N., Khan, A., … Vela, M. F. (2020). The functional lumen imaging probe in gastrointestinal disorders: the past, present, and future. Annals of the New York Academy of Sciences.

Occam's Razor: An Unusual Shoulder Mass in a Patient with Achalasia.
Weingarden, A. R., Villescas, V., Clarke, J., & Triadafilopoulos, G. (2020). Occam's Razor: An Unusual Shoulder Mass in a Patient with Achalasia. Digestive Diseases and Sciences.

Gastric antral vascular ectasia in systemic sclerosis: Association with anti-RNA polymerase III and negative anti-nuclear antibodies.
Serling-Boyd, N., Chung, M. P.-S., Li, S., Becker, L., Fernandez-Becker, N., Clarke, J., … Chung, L. (2020). Gastric antral vascular ectasia in systemic sclerosis: Association with anti-RNA polymerase III and negative anti-nuclear antibodies. Seminars in Arthritis and Rheumatism, 50(5), 938–42.

Type II Achalasia Is Increasing in Prevalence.
Zhou, M. J., Kamal, A., Freedberg, D. E., Markowitz, D., Clarke, J. O., & Jodorkovsky, D. (2020). Type II Achalasia Is Increasing in Prevalence. Digestive Diseases and Sciences.

Patient Reported Outcomes and Objective Swallowing Assessments in a Multidisciplinary Dysphagia Clinic.
Dewan, K., Clarke, J. O., Kamal, A. N., Nandwani, M., & Starmer, H. M. (2020). Patient Reported Outcomes and Objective Swallowing Assessments in a Multidisciplinary Dysphagia Clinic. The Laryngoscope.

Achalasia: physiology and diagnosis.
Rieder, E., Fernandez-Becker, N. Q., Sarosiek, J., Guillaume, A., Azagury, D. E., & Clarke, J. O. (2020). Achalasia: physiology and diagnosis. Annals of the New York Academy of Sciences.

Baseline impedance via manometry and ambulatory reflux testing are not equivalent when utilized in the evaluation of potential extra-esophageal gastroesophageal reflux disease.
Zikos, T. A., Triadafilopoulos, G., Kamal, A., Podboy, A., Sonu, I. S., Regalia, K. A., … Clarke, J. O. (2020). Baseline impedance via manometry and ambulatory reflux testing are not equivalent when utilized in the evaluation of potential extra-esophageal gastroesophageal reflux disease. Journal of Thoracic Disease, 12(10), 5628–38.

Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS).
Zhou, W., Zikos, T. A., Clarke, J. O., Nguyen, L. A., Triadafilopoulos, G., & Neshatian, L. (2021). Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS). Digestive Diseases and Sciences.

Development of quality indicators for the diagnosis and management of achalasia.
Kamal, A. N., Kathpalia, P., Otaki, F., Bredenoord, A. J., Castell, D. O., Clarke, J. O., … Leiman, D. A. (2021). Development of quality indicators for the diagnosis and management of achalasia. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e14118.

The Stanford Multidisciplinary Swallowing Disorders Center.
Nandwani, M., Dewan, K., Starmer, H., Kamal, A. N., & Clarke, J. O. (2021). The Stanford Multidisciplinary Swallowing Disorders Center. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association.

Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis.
Gottfried-Blackmore, A., Namkoong, H., Adler, E., Martin, B., Gubatan, J., Fernandez-Becker, N., … Habtezion, A. (2021). Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis. Clinical and Translational Gastroenterology, 12(5), e00349.

Question Prompt List as a Communication Tool for Adults with Gastroesophageal Reflux Disease Incorporation of Patients' Perspectives.
Kamal, A., Achkar, E., Carlson, D., Clarke, J., Fass, R., Gyawali, C. P., … Triadafilopoulos, G. (2021). Question Prompt List as a Communication Tool for Adults with Gastroesophageal Reflux Disease Incorporation of Patients' Perspectives. Journal of Clinical Gastroenterology.

Classifying Esophageal Motility by FLIP Panometry: A Study of 722 Subjects With Manometry.
Carlson, D. A., Gyawali, C. P., Khan, A., Yadlapati, R., Chen, J., Chokshi, R. V., … Pandolfino, J. E. (2021). Classifying Esophageal Motility by FLIP Panometry: A Study of 722 Subjects With Manometry. The American Journal of Gastroenterology.

A Comprehensive Approach to Esophageal Symptoms and Disorders.
Clarke, J. O. (2021). A Comprehensive Approach to Esophageal Symptoms and Disorders. Gastroenterology Clinics of North America, 50(4), xiii-xiv.

Scleroderma and the Esophagus.
Ahuja, N. K., & Clarke, J. O. (2021). Scleroderma and the Esophagus. Gastroenterology Clinics of North America, 50(4), 905–918.

The Effects of Intermittent Fasting on Gastroesophageal Reflux Disease
Jiang, Y., Goodman, S., Sonu, I., Garcia, P., Fernandez-Becker, N., Kamal, A., … Clarke, J. (2021). The Effects of Intermittent Fasting on Gastroesophageal Reflux Disease. AMERICAN JOURNAL OF GASTROENTEROLOGY. LIPPINCOTT WILLIAMS & WILKINS.

Development of a Preliminary Question Prompt List as a Communication Tool for Adults With Achalasia: A Modified Delphi Study.
Zhuo, J., Triadafilopoulos, G., Bredenoord, A. J., Clarke, J. O., Fass, R., Gyawali, C. P., … Kamal, A. N. (2022). Development of a Preliminary Question Prompt List as a Communication Tool for Adults With Achalasia: A Modified Delphi Study. Journal of Clinical Gastroenterology.

Intra-subject Variability in High Resolution Anorectal Manometry Using the London Classification: Diagnostic and Therapeutic Implications.
Triadafilopoulos, G., Clarke, J. O., Kamal, A., & Neshatian, L. (2022). Intra-subject Variability in High Resolution Anorectal Manometry Using the London Classification: Diagnostic and Therapeutic Implications. Digestive Diseases and Sciences.

Quantitative assessment of multichannel intraluminal impedance pH and its clinical implications.
Koo, E., Clarke, J. O., Yang, B., Pasricha, P. J., & Zhang, N. (2022). Quantitative assessment of multichannel intraluminal impedance pH and its clinical implications. Physiological Reports, 10(4), e15199.

Model for multi-disciplinary, multi-institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases.
Kamal, A. N., Triadafilopoulos, G., Gyawali, C. P., Nguyen, L., Sayuk, G. S., Azagury, D. E., … Clarke, J. O. (2022). Model for multi-disciplinary, multi-institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e14369.

Prevention of Esophageal Cancer.
Clarke, J. (2021). Prevention of Esophageal Cancer. Gastroenterology & Hepatology, 17(12), 609–611.

Clinical role of ambulatory reflux monitoring in PPI non-responders: Recommendation statements.
Yadlapati, R., Gawron, A. J., Gyawali, C. P., Chen, J., Clarke, J., Fass, R., … Pandolfino, J. E. (2022). Clinical role of ambulatory reflux monitoring in PPI non-responders: Recommendation statements. Alimentary Pharmacology & Therapeutics.

Best Practices in Treatment of Laryngopharyngeal Reflux Disease: A Multidisciplinary Modified Delphi Study.
Kamal, A. N., Dhar, S. I., Bock, J. M., Clarke, J. O., Lechien, J. R., Allen, J., … Akst, L. M. (2022). Best Practices in Treatment of Laryngopharyngeal Reflux Disease: A Multidisciplinary Modified Delphi Study. Digestive Diseases and Sciences.

Healthcare Disparities in Gastroesophageal Reflux Disease for Hispanic and Latino Americans: A Solution-Oriented Approach for Improvement.
Kamal, A. N., Wang, C. J., Triadafilopoulos, G., & Clarke, J. O. (2022). Healthcare Disparities in Gastroesophageal Reflux Disease for Hispanic and Latino Americans: A Solution-Oriented Approach for Improvement. The American Journal of Gastroenterology.

Clinical and manometric characteristics of patients with oesophagogastric outflow obstruction: towards a new classification
Triadafilopoulos, G., & Clarke, J. O. (2018). Clinical and manometric characteristics of patients with oesophagogastric outflow obstruction: towards a new classification. BMJ OPEN GASTROENTEROLOGY, 5(1).

Inter- and intra-rater agreement of interpretation of functional lumen imaging probe in healthy subjects.
Yadlapati, R., Gyawali, C. P., Carlson, D. A., Pandolfino, J. E., Fass, R., Khan, A., … Clarke, J. O. (2022). Inter- and intra-rater agreement of interpretation of functional lumen imaging probe in healthy subjects. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, e14505.

Helping Patients with Gastroparesis
Onyimba, F. U., & Clarke, J. O. (2019). Helping Patients with Gastroparesis. MEDICAL CLINICS OF NORTH AMERICA, 103(1), 71-+.

Value of 96-hour ambulatory esophageal pH monitoring in the assessment of patients with refractory acid reflux symptoms and their response to anti-reflux diet.
Triadafilopoulos, G., Kamal, A., & Clarke, J. O. (2022). Value of 96-hour ambulatory esophageal pH monitoring in the assessment of patients with refractory acid reflux symptoms and their response to anti-reflux diet. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus.

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

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Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing »

Specializing In

Esophageal manometry
Esophageal Manometry
Esophageal motility disorders including spasm
Esophagogastroduodenoscopy (EGD)
Gastric Electrical Stimulation
Gastric Pacemaker
Gastrostomy (Feeding) Tube
Motility Disorders
Non-cardiac chest pain
Other endoscopic procedures
Paraesophageal Hernias
Sigmoidoscopy
Small bowel manometry
Upper GI endoscopy

Practice Locations

Digestive Health Center in Redwood City Redwood City, CA

Redwood City, CA

Digestive Health Center in Redwood City

420 Broadway Street, Pavilion D, 2nd Floor

Redwood City , CA 94063

(650) 736-5555

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Esophagus Center Redwood City, CA

Redwood City, CA

Esophagus Center

420 Broadway Street, Pavilion D, 2nd Floor

Redwood City , CA 94063

(650) 736-5555

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Amyloid Center Stanford, CA

Stanford, CA

Amyloid Center

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 725-6186

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General Endoscopy Redwood City, CA

Redwood City, CA

General Endoscopy

420 Broadway Street, Pavilion D, 2nd Floor

Redwood City , CA 94063

(650) 736-5555

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(9 Ratings)

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4.7/5

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Patient Reviews

(88 reviews)

After 2 years, Dr. Clarke has yet to figure out what's wrong with me.

Jan 2021

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Verified SHC Patient

Dr. John Clarke is amazingly good - Both in "bedside manner" and understanding the medical issues and explaining them in an honest manner to the patient.

Aug 2020

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Verified SHC Patient

The best doctor ever!

Aug 2020

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Verified SHC Patient

Dr. Clarke is an excellent care giver, very professional and caring.\

Feb 2020

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Verified SHC Patient

amazing care, awesome Doctor. things are always explained in a way I can understand. any questions or concerns I have are always addressed.

Feb 2020

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Verified SHC Patient

Dr. Clarke is the best doctor that performed my colonoscopy procedure.

Jan 2020

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Verified SHC Patient

Genuinely concerned included me in decisions about my care. was not rushed

Jan 2020

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Verified SHC Patient

Best doctor ever! Friendly, listens explains any concerns. Have total trust in Dr. Clarke. Only wish there were more doctors like him.

Jan 2020

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Verified SHC Patient

was impressed with Dr. Clark

Dec 2019

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Verified SHC Patient

Dr. Clarke is fantastic and has been an exemplary example of the professionalism and world-class level of care provided by Stanford.

Dec 2019

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Verified SHC Patient

It was a pleasure to talk with a physician who is not only kind and considerate, but who clearly knows your situation and how best to deal with it.

Dec 2019

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Verified SHC Patient

Dr. Clark does an excellent job. Explains everything clearly -

Dec 2019

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Verified SHC Patient

Dr. Clarke is a very kind, caring and compassionate doctor. He is extremely knowledgeable in Motility and Scleroderma GI involvement which is mandatory for a patient such as myself. I feel very confident in his treatments and advice.

Nov 2019

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Verified SHC Patient

Dr. Clark "ROCKS." Dr. Clark - 1:1 meeting.

Nov 2019

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Verified SHC Patient

Dr. Clarke is always very attentive and puts you at ease.

Nov 2019

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Verified SHC Patient

I'm not really one of those people who marks very good for everything, but this just so happens to be the truth. This provider speaks to you as an equal, with thorough amount of in-depth information so you can make good decisions for yourself about your care. Really the best provider I have ever seen for any issue or trouble.

Oct 2019

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Verified SHC Patient

Dr. Clark is an amazing, caring, and knowledgeable doctor.

Oct 2019

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Verified SHC Patient

Dr. Clarke is amazing! I've been very ill for a long time and for the first time I've been given hope. He is very knowledgeable, caring, and thorough. I have not been this impressed with a care provider before. I am grateful to be under his care.

Sep 2019

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Verified SHC Patient

Dr. Clarke performed his duties above and beyond. I have utmost confident in his medical abilities.

Sep 2019

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Verified SHC Patient

Excellent providers. Did a wonderful job in answering all my questions.

Aug 2019

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Verified SHC Patient

Dr. Clarke is an exceptionally great specialist. He is also a great human being with understanding compassion and patience.

Aug 2019

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Verified SHC Patient

Dr. Clarke was extremely knowledgeable about my symptoms and conditions. He put me at ease with treatment options and further care. He was not in any rush and I appreciated the time and thoroughness he gave me.

Aug 2019

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Verified SHC Patient

Dr Clarke is the best all around!

Jul 2019

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Verified SHC Patient

Although he was running quite late due to the crisis, he did not make us feel hurried and answered all questions asked of him.

Jul 2019

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Verified SHC Patient

Excellent

Jun 2019

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Verified SHC Patient

shared with neighbors ,friends and family what a good experience we had . Neighbor has already called and schedule a visit with the provider.

Jun 2019

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Verified SHC Patient

Dr. Clarke is an excellent physician.

May 2019

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Verified SHC Patient

MD and resident & intern were great. Stanford itself, though, always leaves much to be desired where support staff and such are concerned.

May 2019

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Verified SHC Patient

Dr. Clarke is wonderful. Kind and considerate of my issues and general health! He is reassuring and gives me hope.

Apr 2019

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Verified SHC Patient

As much as the dr. as his personnel are very nice and humanitarian.

Apr 2019

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Verified SHC Patient

I was pleased with the care I received. The doctor answered all questions and addressed my concerns. He was patient and did not make me feel rushed. I appreciated the amount of time he dedicated to my appointment.

Mar 2019

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Verified SHC Patient

Even as we were late he spent time with us as needed.

Mar 2019

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Verified SHC Patient

Clarke and his PAs have been great. We are working through a plan and he's been supportive of my desire and needs. I've already recommended him to others.

Mar 2019

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Verified SHC Patient

Good.

Mar 2019

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Verified SHC Patient

Dr. Clarke was very professional & informative.

Mar 2019

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Verified SHC Patient

Dr. Clarke is a very patient doctor.

Mar 2019

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Verified SHC Patient

I know that my mother is in very good hands with Dr. Clarke. He takes the time to listen to her. He asks for her opinion about other care options and is very empathetic and concerned for her health. Her health is what it is but is really helps her to deal with her issues knowing that Dr. Clarke continues to try and provide relief. He also advises of new and upcoming medications that may assist her. We are very grateful to Dr. Clarke for his care of my mother.

Jan 2019

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Verified SHC Patient

Best GI doc I've seen.

Jan 2019

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Verified SHC Patient

The doctor did NOT review my history (medical records) and I had to start again - Very unproductive.

Dec 2018

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Verified SHC Patient

Dr.John Clarke is very personable, helpful and knowledgeable. I am getting to know him more and as of now, I feel comfortble with his approaches.

Dec 2018

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Verified SHC Patient

This is when it gets GOOD!! Dr. Clarke is amazing, kind and spends a lot of time!! Dr. Alexander Podbody is amazing. He has qualities that will make him a successful doctor!!!! Both have great "beside manner."

Dec 2018

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Verified SHC Patient

The problem is a plan is created and then never executed. Also there have been a few times I have messaged using the online portal and no one responds.

Dec 2018

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Verified SHC Patient

I've never spent so much time with a gastroenterologist. Dr. Clark didn't seem to be in a rush (a common experience I've had in the past), and used the information from my esophagus biopsy (done in 2017) to inform me of another illness that I didn't know I had and that was causing a lot of my symptoms. This information and his advice have already made a difference.

Nov 2018

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Verified SHC Patient

Dr Clarke has always had a listening ear and provides a great bedside manner. his knowledge is vast, but he's also willing to admit when things are difficult. he's a wonderful doctor!

Oct 2018

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Verified SHC Patient

Dr. Clarke is a excellent doctor. He is caring and helpful.

Oct 2018

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Verified SHC Patient

Dr. Brian-Clark is fantastic, one of the finest physicians I have ever dealt with. Thank you!

Oct 2018

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Verified SHC Patient

Excellent.

Oct 2018

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Verified SHC Patient

I had a wonderful experience with him. He was very friendly and understanding and accommodating to my needs.

Oct 2018

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Verified SHC Patient

Dr. Clarke is patient, friendly, knowledgable and professional. THANK YOU so much Dr. Clarke.

Oct 2018

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Verified SHC Patient

This is my first visit... overall experience with doctor was good. follow ups and scheduling is pathetic with his staff.

Oct 2018

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Verified SHC Patient

Dr. Clarke epitomizes what an outstanding GI Doctor ought to be. Please keep him happy so he'll stay put.

Oct 2018

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Verified SHC Patient

The care providers were very patient

Sep 2018

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Verified SHC Patient

Good.

Sep 2018

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Verified SHC Patient

Dr. Clarke gave me excellent care, took the time to walk me through my questions.

Aug 2018

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Verified SHC Patient

Dr. Clarke and his associate doctor really listened to all my concerns. Both doctors took their time and never rushed me. It was an extremely positive first experience.

Aug 2018

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Verified SHC Patient

excellent

Jul 2018

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Verified SHC Patient

Doctor Clarke was very kind I liked him. Most doctors I deal with are arrogant he was not.

Jul 2018

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Verified SHC Patient

Excellent provider

Jun 2018

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Verified SHC Patient

Based on similar Drs I have visited in the immediate area Dr Clarke is hands down the most courteous and professional Dr I have found.

May 2018

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Verified SHC Patient

Very good!

Apr 2018

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Verified SHC Patient

Dr. J. O. Clarke was very understanding and answered all my questions. He offered solutions that made sense and overall I felt confident that I will get better.

Feb 2018

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Verified SHC Patient

Dr. Clarke was wonderful and made me feel very comfortable.

Jan 2018

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Verified SHC Patient

These comments refer to Dr. Clarke. I was somewhat concerned that he thought my connective tissue disorder (EDS) didn't apply to internal organs, muscles and viscera--only to skin and joints. I was pleased that he took note with my concern and correction of this perception. Overall, Dr. Clarke was a very kind and knowledgable and a good listener. I wasn't expecting him to suggest P.O.E.M. and had prepped my questions for dilatation, and so afterwards, thought of questions about P.O.E.M. I should have asked...

Jan 2018

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Verified SHC Patient

Excellent service from Dr. John.

Jan 2018

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Verified SHC Patient

Both NP and doctor were very informative and helpful. Great bedside manner!

Dec 2017

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Verified SHC Patient

Dr. Clarke is a very good & caring doctor.

Dec 2017

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Verified SHC Patient

I would recommend my care provider to my family, friends or anyone that I meet.

Dec 2017

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Verified SHC Patient

Dr. Clarke is very personable responsive to my needs and issues good listener and extremely well organized with a PLAN at follow up after endo/colo.

Nov 2017

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Verified SHC Patient

Dr. Clarke is excellent. Very knowledgeable yet humble. He listens very carefully to his patients. Best GI dr. I had every have.

Oct 2017

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Verified SHC Patient

I have already recommended Dr. Clarke to others.

Sep 2017

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Verified SHC Patient

Dr. Clarke seemed to care.

Sep 2017

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Verified SHC Patient

Dr. Clarke is the best.

Aug 2017

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Verified SHC Patient

Again really liked Dr. John Clarke. He's a caring and thoughtful Doctor!

Jul 2017

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Verified SHC Patient

He communicates his expertise in a way I understand and lets me know his reasoning for his decisions.

Jun 2017

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Verified SHC Patient

Dr. Clarke is and patient. My health issues are unusual and complicated and I have really appreciated his persistence in trying to get to the bottom of the problem even though several tests have not yielded any easy answers.

Jun 2017

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Verified SHC Patient

O'Brien is the best GI Doc I've ever seen; and I've seen many. He's smart, keeps up on latest research, friendly, and takes the time to brainstorm options with me.

May 2017

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Verified SHC Patient

This was my first time seeing this dr. He explained things very well.

May 2017

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Verified SHC Patient

Has better insights than other G.I. dr.'s I have seen.

Mar 2017

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Verified SHC Patient

I find it very easy and pleasant to discuss my care with Dr. Clarke. I have great confidence in him.

Mar 2017

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Verified SHC Patient

A most reassuring experience.

Mar 2017

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Verified SHC Patient

Very caring and thoughtful.

Mar 2017

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Verified SHC Patient

Easily the best doctor I have seen. Very precise, helpful. Wish there were more such doctors. When the doctor is confident, the patient feels confident. Dr. Clarke takes the time to answer questions. I trust him.

Feb 2017

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Verified SHC Patient

So thankful to have Dr. Clarke caring for me.

Feb 2017

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Verified SHC Patient

I was very impressed that he did some research/reading about my issues prior to coming in to the room and then told me about what he had learned. Taking that extra step/time did not go unnoticed

Feb 2017

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Verified SHC Patient

Dr. Clarke is amazing! He is very thorough and open to my questions and requests. I have seen several Gastroenterologists and he has been the one to give me the most hope.

Feb 2017

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Verified SHC Patient

Dr. Clarke is awesome.

Jan 2017

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Verified SHC Patient

Dr. O'Brien reviewed my medications and determined that some were those he would prescribe, but possibly in different doses. We agreed that if my symptoms increased again, I would contact him.

Jan 2017

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Verified SHC Patient

Dr. Cooke is a caring, patient, supportive doctor.

Jan 2017

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Verified SHC Patient

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John Clarke

Gastroenterologist, Motility specialist

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Biography

Professional Summary

Professional Education

Honors & Awards

Administrative Appointments

Publications

Clinical Trials

Specializing In

Practice Locations

Digestive Health Center in Redwood City Redwood City, CA

Digestive Health Center in Redwood City

Esophagus Center Redwood City, CA

Esophagus Center

Amyloid Center Stanford, CA

Amyloid Center

General Endoscopy Redwood City, CA

General Endoscopy

Patient Ratings

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Patient Reviews

(88 reviews)

Referring Physicians

PHYSICIAN HELPLINE

New to MyHealth?

ALREADY HAVE AN ACCESS CODE?

DON'T HAVE AN ACCESS CODE?

NEED MORE DETAILS?

MyHealth for Mobile

WELCOME BACK

John Clarke

Gastroenterologist, Motility specialist

Get In Touch

Biography

Professional Summary

Professional Education

Honors & Awards

Administrative Appointments

Publications

Clinical Trials

Specializing In

Practice Locations

Digestive Health Center in Redwood City Redwood City, CA

Digestive Health Center in Redwood City

Esophagus Center Redwood City, CA

Esophagus Center

Amyloid Center Stanford, CA

Amyloid Center

General Endoscopy Redwood City, CA

General Endoscopy

Patient Ratings

How Our Ratings Work

Patient Reviews

(88 reviews)

Referring Physicians

PHYSICIAN HELPLINE