Biography
At Stanford Medicine, Dr. Longo is the George E. and Lucy Becker Professor of Neurology and Professor, by courtesy, of Neurosurgery. He served as the Chair of the Department of Neurology and Neurological Sciences from 2006 to 2023. Along with his colleagues, he focuses on building programs in neurology and the neurosciences.
His interests include translational research in neurodegenerative disease prevention and therapeutics, providing patient care in the Stanford Health Care Memory Disorders Clinic, and mentoring medical students and other trainees.
Dr. Longo is the 2015 recipient of the inaugural Melvin R. Goodes Prize for Excellence in Alzheimer’s Drug Discovery from the Alzheimer’s Drug Discovery Foundation, and his team’s work on Alzheimer’s therapeutics was featured on the cover of Time Magazine in 2016. He currently serves on the National Advisory Council on Aging for the National Institute on Aging at the NIH.
Professional Summary
Education & Certifications
- Medical Education: University of California San Diego School of Medicine (1981) CA
- Board Certification: American Board of Psychiatry and Neurology, Neurology (1989)
- Residency: UCSF Medical Center (1987) CA
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- Internship: New York VA Medical Center (1984) NY
- Ph.D., UC San Diego, Neuroscience (1983)
- M.D., UC San Diego, Medicine (1981)
- BA, UC San Diego, Biology (1977)
Honors & Awards
- Alpha Omega Alpha Honor Medical Society at Stanford, AOA Honor Medical Society (2020)
- Associate Editor, Annals of Neurology (1994-1997)
- Beeson Award, American Federation for Aging Research (1995)
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- Edwin Boldrey Award for Basic Science Research, San Francisco Neurological Society (1990)
- First Place in Neuroscience, National Student Research Forum (1979)
- Melvin R. Goodes Prize for Excellence in Alzheimer’s Drug Discovery, Alzheimer’s Drug Discovery Foundation (2015)
- Outstanding Alumnus Award, UC San Diego (2000)
- Stanford University Fellow, Stanford University (2006-2008)
Administrative Appointments
- Assoc. Chief of Staff for Research and Dev., SF, VAMC (1997 - 2001)
- Assoc. Professor and Vice Chair, UC San Francisco (1996 - 1999)
- Chief, Neurology and Rehab Services, SF, VAMC (1995 - 2001)
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- Professor and Chair, Department of Neurology, University of North Carolina, Chapel Hill (2001 - 2005)
- Professor and Chair, Department of Neurology and Neurological Sciences, Stanford University (2006 - 2023)
- Professor and Vice Chair, UC San Francisco (1999 - 2001)
- Professor, Department of Neurology and Neurological Sciences, Stanford University (2023 - Present)
Publications
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Leukocyte common antigen-related tyrosine phosphatase receptor: Increased expression and neuronal-type splicing in breast cancer cells and tissue
Yang, T., Zhang, J. S., Massa, S. M., Han, X. L., & LONGO, F. M. (1999). Leukocyte common antigen-related tyrosine phosphatase receptor: Increased expression and neuronal-type splicing in breast cancer cells and tissue. MOLECULAR CARCINOGENESIS, 25(2), 139–149. -
Gene expression along the cerebral-spinal axis after regional gene delivery
Meuli-Simmen, C., Liu, Y., Yeo, T. T., Liggitt, D., Tu, G. H., Yang, T., … Debs, R. J. (1999). Gene expression along the cerebral-spinal axis after regional gene delivery. HUMAN GENE THERAPY, 10(16), 2689–2700. -
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma
Yang, T., Martignetti, J. A., Massa, S. M., & Longo, F. M. (2000). Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma. CARCINOGENESIS, 21(2), 125–131. -
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Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth
Tisi, M. A., Xie, Y. M., Yeo, T. T., & Longo, F. M. (2000). Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth. JOURNAL OF NEUROBIOLOGY, 42(4), 477–486. -
Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects
Xie, Y. M., Tisi, M. A., Yeo, T. T., & LONGO, F. M. (2000). Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(38), 29868–29874. -
Stress induces zinc finger immediate early genes in the rat adrenal gland
Honkaniemi, J., Zhang, J. S., LONGO, F. M., & Sharp, F. R. (2000). Stress induces zinc finger immediate early genes in the rat adrenal gland. BRAIN RESEARCH, 877(2), 203–208. -
Neurotrophin small-molecule mimetics
Xie, Y. M., & LONGO, F. M. (2000). Neurotrophin small-molecule mimetics. Presented at the 8th International Symposium on Neural Regeneration, PACIFIC GROVE,CALIFORNIA: ELSEVIER SCIENCE BV. -
The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo
Xie, Y. M., Yeo, T. T., Zhang, C., Yang, T., Tisi, M. A., Massa, S. M., & Longo, F. M. (2001). The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo. JOURNAL OF NEUROSCIENCE, 21(14), 5130–5138. -
Psychological impact of news of genetic risk for Huntington disease
Horowitz, M. J., Field, N. P., Zanko, A., Donnelly, E. F., Epstein, C., & Longo, F. (2001). Psychological impact of news of genetic risk for Huntington disease. AMERICAN JOURNAL OF MEDICAL GENETICS, 103(3), 188–192. -
Alzheimer's therapeutics - Neurotrophin small molecule mimetics
Massa, S. M., Xie, Y. M., & Longo, F. M. (2002). Alzheimer's therapeutics - Neurotrophin small molecule mimetics. JOURNAL OF MOLECULAR NEUROSCIENCE, 19(1-2), 107–111. -
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury
Beattie, M. S., Harrington, A. W., LEE, R., Kim, J. Y., Boyce, S. L., LONGO, F. M., … Yoon, S. O. (2002). ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. NEURON, 36(3), 375–386. -
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation
Buttini, M., Yu, G. Q., Shockley, K., Huang, Y. D., Jones, B., Masliah, E., … Mucke, L. (2002). Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. JOURNAL OF NEUROSCIENCE, 22(24), 10539–10548. -
Leukocyte antigen-related protein tyrosine phosphatase receptor: A small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth
Yang, T., Bernabeu, R., Xie, Y. M., Zhang, J. S., Massa, S. M., Rempel, H. C., & LONGO, F. M. (2003). Leukocyte antigen-related protein tyrosine phosphatase receptor: A small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. JOURNAL OF NEUROSCIENCE, 23(8), 3353–3363. -
A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs
Zhang, C., Xie, Y. M., Martignetti, J. A., Yeo, T. T., Massa, S. M., & Longo, F. M. (2003). A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA AND CELL BIOLOGY, 22(5), 303–315. -
Alzheimer's therapeutics - Neurotrophin domain small molecule mimetics
Massa, S. M., Xie, Y. M., & LONGO, F. M. (2003). Alzheimer's therapeutics - Neurotrophin domain small molecule mimetics. JOURNAL OF MOLECULAR NEUROSCIENCE, 20(3), 323–326. -
HALOPERIDOL PREVENTS INDUCTION OF THE HSP70 HEAT-SHOCK GENE IN NEURONS INJURED BY PHENCYCLIDINE (PCP), MK801, AND KETAMINE
Sharp, F. R., Butman, M., Wang, S., Koistinaho, J., Graham, S. H., Sagar, S. M., … LONGO, F. M. (1992). HALOPERIDOL PREVENTS INDUCTION OF THE HSP70 HEAT-SHOCK GENE IN NEURONS INJURED BY PHENCYCLIDINE (PCP), MK801, AND KETAMINE. JOURNAL OF NEUROSCIENCE RESEARCH, 33(4), 605–616. -
Neurotrophin-based strategies for neuroprotection
Longo, F. M., & Massa, S. M. (2004). Neurotrophin-based strategies for neuroprotection. JOURNAL OF ALZHEIMERS DISEASE, 6(6), S13–S17. -
Neuroprotective strategies in Alzheimer's disease.
Longo, F. M., & Massa, S. M. (2004). Neuroprotective strategies in Alzheimer's disease. NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics, 1(1), 117–127. -
Neurotrophin receptor-based strategies for Alzheimer's disease.
Longo, F. M., & Massa, S. M. (2005). Neurotrophin receptor-based strategies for Alzheimer's disease. Current Alzheimer Research, 2(2), 167–169. -
Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth
Yang, T., Yin, W. N., Derevyanny, V. D., Moore, L. A., & Longo, F. M. (2005). Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth. EUROPEAN JOURNAL OF NEUROSCIENCE, 22(9), 2159–2170. -
Small molecule approaches for promoting neurogenesis.
Longo, F. M., Yang, T., Xie, Y., & Massa, S. M. (2006). Small molecule approaches for promoting neurogenesis. Current Alzheimer Research, 3(1), 5–10. -
Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons
Bernabeu, R., Yang, T., Xie, Y. M., Mehta, B., Ma, S. Y., & Longo, F. M. (2006). Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. MOLECULAR AND CELLULAR NEUROSCIENCE, 31(4), 723–738. -
Protein-tyrosine phosphatase (PTP) wedge domain peptides - A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function
Xie, Y., Massa, S. M., Ensslen-Craig, S. E., Major, D. L., Yang, T., Tisi, M. A., … Longo, F. M. (2006). Protein-tyrosine phosphatase (PTP) wedge domain peptides - A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(24), 16482–92. -
Small, nonpeptide p75(NTR) ligands induce survival signaling and inhibit proNGF-induced death
Massa, S. M., Xie, Y., Yang, T., Harrington, A. W., Kim, M. L., Yoon, S. O., … Longo, F. M. (2006). Small, nonpeptide p75(NTR) ligands induce survival signaling and inhibit proNGF-induced death. JOURNAL OF NEUROSCIENCE, 26(20), 5288–5300. -
Modulation of p75(NTR)-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain
Pehar, M., Cassina, P., Vargas, M. R., Xie, Y., Beckman, J. S., Massa, S. M., … Barbeito, L. (2006). Modulation of p75(NTR)-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. EUROPEAN JOURNAL OF NEUROSCIENCE, 24(6), 1575–1580. -
LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways
Yang, T., Massa, S. M., & Longo, F. M. (2006). LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. JOURNAL OF NEUROBIOLOGY, 66(13), 1420–36. -
E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner
Oblander, S. A., Ensslen-Craig, S. E., Longo, F. M., & Brady-Kalnay, S. M. (2007). E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. MOLECULAR AND CELLULAR NEUROSCIENCE, 34(3), 481–492. -
Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms
Longo, F. M., Yang, T., Knowles, J. K., Xie, Y., Moore, L. A., & Massa, S. M. (2007). Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms. CURRENT ALZHEIMER RESEARCH, 4(5), 503–6. -
Small Molecule Modulation of p75 Neurotrophin Receptor Functions
Longo, F. M., & Massa, S. M. (2008). Small Molecule Modulation of p75 Neurotrophin Receptor Functions. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 7(1), 63–70. -
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
James, S. E., Burden, H., Burgess, R., Xie, Y., Yang, T., Massa, S. M., … Lu, Q. (2008). Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. NEUROTOXICOLOGY, 29(4), 605–12. -
A common motif targets huntingtin and the androgen receptor to the proteasome
Chandra, S., Shao, J., Li, J. X., Li, M., Longo, F. M., & Diamond, M. I. (2008). A common motif targets huntingtin and the androgen receptor to the proteasome. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(35), 23950–55. -
Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit A beta-Induced Neurodegeneration and Synaptic Impairment
Yang, T., Knowles, J. K., Lu, Q., Zhang, H., Arancio, O., Moore, L. A., … Longo, F. M. (2008). Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit A beta-Induced Neurodegeneration and Synaptic Impairment. PLOS ONE, 3(11). -
Signaling Through Rho GTPase Pathway as Viable Drug Target
Lu, Q., Longo, F. M., Zhou, H., Massa, S. M., & Chen, Y.-H. (2009). Signaling Through Rho GTPase Pathway as Viable Drug Target. CURRENT MEDICINAL CHEMISTRY, 16(11), 1355–65. -
The p75 Neurotrophin Receptor Promotes Amyloid-beta(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo
Knowles, J. K., Rajadas, J., Nguyen, T.-V. V., Yang, T., LeMieux, M. C., Griend, L. V., … Longo, F. M. (2009). The p75 Neurotrophin Receptor Promotes Amyloid-beta(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo. JOURNAL OF NEUROSCIENCE, 29(34), 10627–37. -
NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM
MCKINLEY, M. P., LONGO, F. M., Valletta, J. S., Rahbar, F., NEVE, R. L., Prusiner, S. B., & Mobley, W. C. (1990). NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM. PROGRESS IN BRAIN RESEARCH, 86, 227–238. -
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., … Longo, F. M. (2010). Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. JOURNAL OF CLINICAL INVESTIGATION, 120(5), 1774–85. -
DIRECT SEQUENCING OF PCR PRODUCTS USING THE MAXAM-GILBERT METHOD
Stamm, S., & LONGO, F. M. (1990). DIRECT SEQUENCING OF PCR PRODUCTS USING THE MAXAM-GILBERT METHOD. GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 7(5), 142–143. -
The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis
Bernabeu, R. O., & Longo, F. M. (2010). The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis. BMC NEUROSCIENCE, 11. -
THE INVITRO BIOLOGICAL EFFECT OF NERVE GROWTH-FACTOR IS INHIBITED BY SYNTHETIC PEPTIDES
LONGO, F. M., Vu, T. K. H., & Mobley, W. C. (1990). THE INVITRO BIOLOGICAL EFFECT OF NERVE GROWTH-FACTOR IS INHIBITED BY SYNTHETIC PEPTIDES. CELL REGULATION, 1(2), 189–195. -
Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors
Fisher, D., Xing, B., Dill, J., Li, H., Hoang, H. H., Zhao, Z., … Li, S. (2011). Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors. JOURNAL OF NEUROSCIENCE, 31(40), 14051–66. -
Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model
Meeker, R. B., Poulton, W., Feng, W.-H., Hudson, L., & Longo, F. M. (2012). Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 7(2), 388–400. -
A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome
Schmid, D. A., Yang, T., Ogier, M., Adams, I., Mirakhur, Y., Wang, Q., … Katz, D. M. (2012). A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome. JOURNAL OF NEUROSCIENCE, 32(5), 1803–10. -
TROPHIC ACTIONS OF RECOMBINANT HUMAN NERVE GROWTH-FACTOR ON CULTURED RAT EMBRYONIC CNS CELLS
Knusel, B., BURTON, L. E., LONGO, F. M., Mobley, W. C., Koliatsos, V. E., Price, D. L., & HEFTI, F. (1990). TROPHIC ACTIONS OF RECOMBINANT HUMAN NERVE GROWTH-FACTOR ON CULTURED RAT EMBRYONIC CNS CELLS. EXPERIMENTAL NEUROLOGY, 110(3), 274–283. -
Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke
Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K. P., Taravosh-Lahn, K., … Buckwalter, M. S. (2012). Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke. STROKE, 43(7), 1918–24. -
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.
Faizi, M., Bader, P. L., Saw, N., Nguyen, T.-V. V., Beraki, S., Wyss-Coray, T., … Shamloo, M. (2012). Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain and Behavior, 2(2), 142–54. -
Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
Tep, C., Lim, T. H., Ko, P. O., Getahun, S., Ryu, J. C., Goettl, V. M., … Yoon, S. O. (2013). Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury. JOURNAL OF NEUROSCIENCE, 33(2), 397–410. -
A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Knowles, J. K., Simmons, D. A., Nguyen, T.-V. V., Vander Griend, L., Xie, Y., Zhang, H., … Longo, F. M. (2013). A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging, 34(8), 2052–63. -
DEVELOPMENTAL REGULATION OF NERVE GROWTH-FACTOR AND ITS RECEPTOR IN THE RAT CAUDATE PUTAMEN
Mobley, W. C., Woo, J. E., Edwards, R. H., Riopelle, R. J., LONGO, F. M., Weskamp, G., … Johnston, M. V. (1989). DEVELOPMENTAL REGULATION OF NERVE GROWTH-FACTOR AND ITS RECEPTOR IN THE RAT CAUDATE PUTAMEN. NEURON, 3(5), 655–664. -
NERVE REGENERATION THROUGH ARTIFICIAL TUBULAR IMPLANTS
Fields, R. D., LEBEAU, J. M., LONGO, F. M., & Ellisman, M. H. (1989). NERVE REGENERATION THROUGH ARTIFICIAL TUBULAR IMPLANTS. PROGRESS IN NEUROBIOLOGY, 33(2), 87-? -
DELAYED NERVE REGENERATION IN STREPTOZOTOCIN DIABETIC RATS
LONGO, F. M., Powell, H. C., Lebeau, J., Gerrero, M. R., Heckman, H., & Myers, R. R. (1986). DELAYED NERVE REGENERATION IN STREPTOZOTOCIN DIABETIC RATS. MUSCLE & NERVE, 9(5), 385–393. -
WHITE MATTER DISEASE IN AIDS - FINDINGS AT MR IMAGING
OLSEN, W. L., LONGO, F. M., Mills, C. M., & Norman, D. (1988). WHITE MATTER DISEASE IN AIDS - FINDINGS AT MR IMAGING. RADIOLOGY, 169(2), 445–448. -
ABNORMAL NERVE REGENERATION IN GALACTOSE NEUROPATHY
Powell, H. C., LONGO, F. M., LEBEAU, J. M., & Myers, R. R. (1986). ABNORMAL NERVE REGENERATION IN GALACTOSE NEUROPATHY. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 45(2), 151–160. -
RELATION OF SOMAL LIPID-SYNTHESIS TO THE FAST AXONAL-TRANSPORT OF PROTEIN AND LIPID
LONGO, F. M., & Hammerschlag, R. (1980). RELATION OF SOMAL LIPID-SYNTHESIS TO THE FAST AXONAL-TRANSPORT OF PROTEIN AND LIPID. BRAIN RESEARCH, 193(2), 471–485. -
NEURITE-PROMOTING FACTORS AND EXTRACELLULAR-MATRIX COMPONENTS ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS
LONGO, F. M., HAYMAN, E. G., Davis, G. E., RUOSLAHTI, E., ENGVALL, E., MANTHORPE, M., & VARON, S. (1984). NEURITE-PROMOTING FACTORS AND EXTRACELLULAR-MATRIX COMPONENTS ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS. BRAIN RESEARCH, 309(1), 105–117. -
SPATIAL-TEMPORAL PROGRESS OF PERIPHERAL-NERVE REGENERATION WITHIN A SILICONE CHAMBER - PARAMETERS FOR A BIOASSAY
Williams, L. R., LONGO, F. M., Powell, H. C., Lundborg, G., & VARON, S. (1983). SPATIAL-TEMPORAL PROGRESS OF PERIPHERAL-NERVE REGENERATION WITHIN A SILICONE CHAMBER - PARAMETERS FOR A BIOASSAY. JOURNAL OF COMPARATIVE NEUROLOGY, 218(4), 460–470. -
LAMININ PROMOTES NEURITIC REGENERATION FROM CULTURED PERIPHERAL AND CENTRAL NEURONS
MANTHORPE, M., ENGVALL, E., RUOSLAHTI, E., LONGO, F. M., Davis, G. E., & VARON, S. (1983). LAMININ PROMOTES NEURITIC REGENERATION FROM CULTURED PERIPHERAL AND CENTRAL NEURONS. JOURNAL OF CELL BIOLOGY, 97(6), 1882–1890. -
NEURONOTROPHIC ACTIVITIES IN CEREBROSPINAL-FLUID OF HEAD TRAUMA PATIENTS
LONGO, F. M., Selak, I., Zovickian, J., MANTHORPE, M., VARON, S., & U, H. S. (1984). NEURONOTROPHIC ACTIVITIES IN CEREBROSPINAL-FLUID OF HEAD TRAUMA PATIENTS. EXPERIMENTAL NEUROLOGY, 84(1), 207–218. -
NEURONOTROPHIC ACTIVITIES ACCUMULATE INVIVO WITHIN SILICONE NERVE REGENERATION CHAMBERS
LONGO, F. M., MANTHORPE, M., Skaper, S. D., Lundborg, G., & VARON, S. (1983). NEURONOTROPHIC ACTIVITIES ACCUMULATE INVIVO WITHIN SILICONE NERVE REGENERATION CHAMBERS. BRAIN RESEARCH, 261(1), 109–116. -
NEURONOTROPHIC ACTIVITY IN BRAIN WOUNDS OF THE DEVELOPING RAT - CORRELATION WITH IMPLANT SURVIVAL IN THE WOUND CAVITY
MANTHORPE, M., NIETOSAMPEDRO, M., Skaper, S. D., Lewis, E. R., Barbin, G., LONGO, F. M., … VARON, S. (1983). NEURONOTROPHIC ACTIVITY IN BRAIN WOUNDS OF THE DEVELOPING RAT - CORRELATION WITH IMPLANT SURVIVAL IN THE WOUND CAVITY. BRAIN RESEARCH, 267(1), 47–56. -
ENDOGENOUS AND EXOGENOUS FACTORS SUPPORT NEURONAL SURVIVAL AND CHOLINE-ACETYLTRANSFERASE ACTIVITY IN EMBRYONIC SPINAL-CORD CULTURES
MANTHORPE, M., Luyten, W., LONGO, F. M., & VARON, S. (1983). ENDOGENOUS AND EXOGENOUS FACTORS SUPPORT NEURONAL SURVIVAL AND CHOLINE-ACETYLTRANSFERASE ACTIVITY IN EMBRYONIC SPINAL-CORD CULTURES. BRAIN RESEARCH, 267(1), 57–66. -
TEMPORAL CHANGES OF NEURONOTROPHIC ACTIVITIES ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS
LONGO, F. M., Skaper, S. D., MANTHORPE, M., Williams, L. R., Lundborg, G., & VARON, S. (1983). TEMPORAL CHANGES OF NEURONOTROPHIC ACTIVITIES ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS. EXPERIMENTAL NEUROLOGY, 81(3), 756–769. -
NERVE REGENERATION MODEL AND TROPHIC FACTORS INVIVO
Lundborg, G., LONGO, F. M., & VARON, S. (1982). NERVE REGENERATION MODEL AND TROPHIC FACTORS INVIVO. BRAIN RESEARCH, 232(1), 157–161. -
Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media.
LONGO, F. M., MANTHORPE, M., & VARON, S. (1982). Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media. Brain Research, 255(2), 277–294. -
INVIVO REGENERATION OF CUT NERVES ENCASED IN SILICONE TUBES - GROWTH ACROSS A 6-MILLIMETER GAP
Lundborg, G., Gelberman, R. H., LONGO, F. M., Powell, H. C., & VARON, S. (1982). INVIVO REGENERATION OF CUT NERVES ENCASED IN SILICONE TUBES - GROWTH ACROSS A 6-MILLIMETER GAP. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 41(4), 412–422. -
NERVE REGENERATION IN SILICONE CHAMBERS - INFLUENCE OF GAP LENGTH AND OF DISTAL STUMP COMPONENTS
Lundborg, G., Dahlin, L. B., Danielsen, N., Gelberman, R. H., LONGO, F. M., Powell, H. C., & VARON, S. (1982). NERVE REGENERATION IN SILICONE CHAMBERS - INFLUENCE OF GAP LENGTH AND OF DISTAL STUMP COMPONENTS. EXPERIMENTAL NEUROLOGY, 76(2), 361–375. -
BRAIN INJURY CAUSES A TIME-DEPENDENT INCREASE IN NEURONOTROPHIC ACTIVITY AT THE LESION SITE
NIETOSAMPEDRO, M., Lewis, E. R., Cotman, C. W., MANTHORPE, M., Skaper, S. D., Barbin, G., … VARON, S. (1982). BRAIN INJURY CAUSES A TIME-DEPENDENT INCREASE IN NEURONOTROPHIC ACTIVITY AT THE LESION SITE. SCIENCE, 217(4562), 860–861. -
COMPARATIVE FEATURES OF SPINAL NEURONOTROPHIC FACTORS IN FLUIDS COLLECTED INVITRO AND INVIVO
MANTHORPE, M., LONGO, F. M., & VARON, S. (1982). COMPARATIVE FEATURES OF SPINAL NEURONOTROPHIC FACTORS IN FLUIDS COLLECTED INVITRO AND INVIVO. JOURNAL OF NEUROSCIENCE RESEARCH, 8(2-3), 241–250. -
NERVE REGENERATION ACROSS AN EXTENDED GAP - A NEUROBIOLOGICAL VIEW OF NERVE REPAIR AND THE POSSIBLE INVOLVEMENT OF NEURONOTROPHIC FACTORS
Lundborg, G., Dahlin, L. B., Danielsen, N., Hansson, H. A., Johannesson, A., LONGO, F. M., … Engin, D. (1982). NERVE REGENERATION ACROSS AN EXTENDED GAP - A NEUROBIOLOGICAL VIEW OF NERVE REPAIR AND THE POSSIBLE INVOLVEMENT OF NEURONOTROPHIC FACTORS. JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 7(6), 580–587. -
Growth factors and motor neurons.
VARON, S., MANTHORPE, M., & LONGO, F. M. (1982). Growth factors and motor neurons. Advances in Neurology, 36, 453–472. -
CLONING OF RAT GRP75, AN HSP70-FAMILY MEMBER, AND ITS EXPRESSION IN NORMAL AND ISCHEMIC BRAIN
Massa, S. M., LONGO, F. M., Zuo, J., Wang, S., Chen, J., & Sharp, F. R. (1995). CLONING OF RAT GRP75, AN HSP70-FAMILY MEMBER, AND ITS EXPRESSION IN NORMAL AND ISCHEMIC BRAIN. JOURNAL OF NEUROSCIENCE RESEARCH, 40(6), 807–819. -
LAR TYROSINE PHOSPHATASE RECEPTOR - ALTERNATIVE SPLICING IS PREFERENTIAL TO THE NERVOUS-SYSTEM, COORDINATED WITH CELL-GROWTH AND GENERATES NOVEL ISOFORMS CONTAINING EXTENSIVE CAG REPEATS
Zhang, J. S., & LONGO, F. M. (1995). LAR TYROSINE PHOSPHATASE RECEPTOR - ALTERNATIVE SPLICING IS PREFERENTIAL TO THE NERVOUS-SYSTEM, COORDINATED WITH CELL-GROWTH AND GENERATES NOVEL ISOFORMS CONTAINING EXTENSIVE CAG REPEATS. JOURNAL OF CELL BIOLOGY, 128(3), 415–431. -
WILL CILIARY NEUROTROPHIC FACTOR SLOW PROGRESSION OF MOTOR-NEURON DISEASE
LONGO, F. M. (1994). WILL CILIARY NEUROTROPHIC FACTOR SLOW PROGRESSION OF MOTOR-NEURON DISEASE. ANNALS OF NEUROLOGY, 36(2), 125–127. -
LEUKOCYTE COMMON ANTIGEN-RELATED RECEPTOR-LINKED TYROSINE PHOSPHATASE - REGULATION OF MESSENGER-RNA EXPRESSION
LONGO, F. M., Martignetti, J. A., LEBEAU, J. M., Zhang, J. S., Barnes, J. P., & Brosius, J. (1993). LEUKOCYTE COMMON ANTIGEN-RELATED RECEPTOR-LINKED TYROSINE PHOSPHATASE - REGULATION OF MESSENGER-RNA EXPRESSION. JOURNAL OF BIOLOGICAL CHEMISTRY, 268(35), 26503–26511. -
PROLONGED INCREASES IN NEUROTROPHIC ACTIVITY ASSOCIATED WITH KAINATE-INDUCED HIPPOCAMPAL SYNAPTIC REORGANIZATION
Lowenstein, D. H., SEREN, M. S., & LONGO, F. M. (1993). PROLONGED INCREASES IN NEUROTROPHIC ACTIVITY ASSOCIATED WITH KAINATE-INDUCED HIPPOCAMPAL SYNAPTIC REORGANIZATION. NEUROSCIENCE, 56(3), 597–604. -
CDNA CLONING AND EXPRESSION OF STRESS-INDUCIBLE RAT HSP70 IN NORMAL AND INJURED RAT-BRAIN
LONGO, F. M., Wang, S., Narasimhan, P., Zhang, J. S., Chen, J., Massa, S. M., & Sharp, F. R. (1993). CDNA CLONING AND EXPRESSION OF STRESS-INDUCIBLE RAT HSP70 IN NORMAL AND INJURED RAT-BRAIN. JOURNAL OF NEUROSCIENCE RESEARCH, 36(3), 325–335. -
INDUCTION OF GLUCOSE-REGULATED PROTEIN (GRP78) AND INDUCIBLE HEAT-SHOCK PROTEIN (HSP70) MESSENGER-RNAS IN RAT-BRAIN AFTER KAINIC ACID SEIZURES AND FOCAL ISCHEMIA
Wang, S., LONGO, F. M., Chen, J., Butman, M., Graham, S. H., Haglid, K. G., & Sharp, F. R. (1993). INDUCTION OF GLUCOSE-REGULATED PROTEIN (GRP78) AND INDUCIBLE HEAT-SHOCK PROTEIN (HSP70) MESSENGER-RNAS IN RAT-BRAIN AFTER KAINIC ACID SEIZURES AND FOCAL ISCHEMIA. NEUROCHEMISTRY INTERNATIONAL, 23(6), 575–582. -
HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE
Sharp, F. R., Butman, M., Wang, S., Koistinaho, J., Graham, S. H., Sagar, S. M., … LONGO, F. M. (1993). HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 679, 288–290. -
Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation
Yeo, T. T., Yang, T., Massa, S. M., Zhang, J. S., Honkaniemi, J., Butcher, L. L., & LONGO, F. M. (1997). Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. JOURNAL OF NEUROSCIENCE RESEARCH, 47(3), 348–360. -
Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats
Mizisin, A. P., Calcutt, N. A., DiStefano, P. S., Acheson, A., & LONGO, F. M. (1997). Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. DIABETES, 46(4), 647–652. -
Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism
LONGO, F. M., MANTHORPE, M., Xie, Y. M., & VARON, S. (1997). Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. JOURNAL OF NEUROSCIENCE RESEARCH, 48(1), 1–17. -
Absence of p75(NTR) causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
Yeo, T. T., CHUACOUZENS, J., Butcher, L. L., Bredesen, D. E., Cooper, J. D., Valletta, J. S., … LONGO, F. M. (1997). Absence of p75(NTR) causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. JOURNAL OF NEUROSCIENCE, 17(20), 7594–7605. -
LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific
Zhang, J. S., Honkaniemi, J., Yang, T., Yeo, T. T., & LONGO, F. M. (1998). LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific. MOLECULAR AND CELLULAR NEUROSCIENCE, 10(5-6), 271–286. -
LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific.
Zhang, Honkaniemi, Yang, Yeo, & Longo. (1998). LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific. Molecular and Cellular Neurosciences, 10(5/6), 271–286. -
Minimized hormones grow in stature
LONGO, F. M., & Mobley, W. C. (1996). Minimized hormones grow in stature. NATURE BIOTECHNOLOGY, 14(9), 1092–1092. -
LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization
Honkaniemi, J., Zhang, J. S., Yang, T., Zhang, C., Tisi, M. A., & LONGO, F. M. (1998). LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization. MOLECULAR BRAIN RESEARCH, 60(1), 1–12. -
Electromagnetic fields influence NGF activity and levels following sciatic nerve transection
Longo, F. M., Yang, T., Hamilton, S., Hyde, J. F., Walker, J., Jennes, L., … Sisken, B. F. (1999). Electromagnetic fields influence NGF activity and levels following sciatic nerve transection. JOURNAL OF NEUROSCIENCE RESEARCH, 55(2), 230–237. -
Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders
Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders. (2005). Curr Med Chem - CNS Agents, 5. -
LAR IS A FUNCTIONAL RECEPTOR FOR CSPG AXON GROWTH INHIBITORS
Li, S., Fisher, D., Xing, B., Li, H., Hoang, H., Cannon, S., … Silver, J. (2011). LAR IS A FUNCTIONAL RECEPTOR FOR CSPG AXON GROWTH INHIBITORS. JOURNAL OF NEUROTRAUMA, 28(6), A2–A3. -
Optimizing the use of CROs by academia and small companies.
Lane, R. F., Friedman, L. G., Keith, C., Braithwaite, S. P., Frearson, J. A., Lowe, D. A., … Fillit, H. M. (2013). Optimizing the use of CROs by academia and small companies. Nature Reviews. Drug Discovery, 12(7), 487–8. -
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease
Longo, F. M., & Massa, S. M. (2013). Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. NATURE REVIEWS DRUG DISCOVERY, 12(7), 507–25. -
Alzheimer's therapeutics: Neurotrophin small molecule mimetics
Massa, S. M., Xie, Y. M., & LONGO, F. M. (2002). Alzheimer's therapeutics: Neurotrophin small molecule mimetics. Presented at the 1st Annual Investigators Meeting, TARRYTOWN,NY: SPRINGER PUBLISHING CO. -
SPINAL-CORD NEURONOTROPHIC FACTORS (SCNTFS) .1. BIOASSAY OF SCHWANNOMA AND OTHER CONDITIONED MEDIA
LONGO, F. M., MANTHORPE, M., & VARON, S. (1982). SPINAL-CORD NEURONOTROPHIC FACTORS (SCNTFS) .1. BIOASSAY OF SCHWANNOMA AND OTHER CONDITIONED MEDIA. DEVELOPMENTAL BRAIN RESEARCH, 3(2), 277–294. -
Trinucleotide repeats in transgenic mice: New insights
LONGO, F. M., & Massa, S. M. (1997). Trinucleotide repeats in transgenic mice: New insights. NEUROSCIENTIST, 3(5), 273–275. -
A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease.
Simmons, D. A., Belichenko, N. P., Yang, T., Condon, C., Monbureau, M., Shamloo, M., … Longo, F. M. (2013). A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease. Journal of Neuroscience , 33(48), 18712–27. -
A Small Molecule p75(NTR) Ligand Protects Neurogenesis After Traumatic Brain Injury
Shi, J., Longo, F. M., & Massa, S. M. (2013). A Small Molecule p75(NTR) Ligand Protects Neurogenesis After Traumatic Brain Injury. STEM CELLS, 31(11), 2561–74. -
Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice.
Nguyen, T.-V. V., Shen, L., Vander Griend, L., Quach, L. N., Belichenko, N. P., Saw, N., … Longo, F. M. (2014). Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. Journal of Alzheimer's Disease : JAD, 42(2), 459–83. -
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., … Wyss-Coray, T. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine, 20(6), 659–63. -
Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury
Xu, B., Park, D., Ohtake, Y., Li, H., Hayat, U., Liu, J., … Li, S. (2015). Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury. NEUROBIOLOGY OF DISEASE, 73, 36–48. -
A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome.
Kron, M., Lang, M., Adams, I. T., Sceniak, M., Longo, F., & Katz, D. M. (2014). A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. Disease Models & Mechanisms, 7(9), 1047–55. -
Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Grabenstatter, H. L., Carlsen, J., Raol, Y. H., Yang, T., HUND, D., Cruz Del Angel, Y., … Brooks-Kayal, A. R. (2014). Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. Journal of Neuroscience Research, 92(10), 1307–1318. -
Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR)
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR). NEUROTOXICOLOGY, 45, 81–90. -
Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.)
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.). Neurotoxicology. -
Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.)
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.). Neurotoxicology. -
Small Molecule p75(NTR) Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in A beta PPL/S Transgenic Mice
Nguyen, T.-V. V., Shen, L., Vander Griend, L., Quach, L. N., Belichenko, N. P., Saw, N., … Longo, F. M. (2014). Small Molecule p75(NTR) Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in A beta PPL/S Transgenic Mice. JOURNAL OF ALZHEIMERS DISEASE, 42(2), 459–83. -
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke.
Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T.-V. V., Soler-Llavina, G. J., … Buckwalter, M. S. (2015). B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke. Journal of Neuroscience , 35(5), 2133–45. -
PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide.
James, M. L., Belichenko, N. P., Nguyen, T.-V. V., Andrews, L. E., Ding, Z., Liu, H., … Chin, F. T. (2015). PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 56(2), 311–16. -
A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance
Malkovskiy, A. V., Wagh, D. A., LONGO, F. M., & Rajadas, J. (2015). A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance. ANALYST, 140(13), 4558–4565. -
A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression.
Simmons, D. A., Knowles, J. K., Belichenko, N. P., Banerjee, G., Finkle, C., Massa, S. M., & Longo, F. M. (2014). A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression. PloS One, 9(8), e102136. -
Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis
Meeker, R. B., Poulton, W., Clary, G., Schriver, M., & Longo, F. M. (2016). Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis. EXPERIMENTAL NEUROLOGY, 275, 182–98. -
The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation
Warnault, V., Darcq, E., Morisot, N., Phamluong, K., Wilbrecht, L., Massa, S. M., … Ron, D. (2016). The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. BIOLOGICAL PSYCHIATRY, 79(6), 463–73. -
A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.
Yang, T., Massa, S. M., Tran, K. C., Simmons, D. A., Rajadas, J., Zeng, A. Y., … Longo, F. M. (2016). A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology, 110, 343–61. -
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Simmons, D. A., Belichenko, N. P., Ford, E. C., Semaan, S., Monbureau, M., Aiyaswamy, S., … Longo, F. M. (2016). A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. -
The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.
Darcq, E., Morisot, N., Phamluong, K., Warnault, V., Jeanblanc, J., Longo, F. M., … Ron, D. (2016). The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. Journal of Neuroscience , 36(39), 10116–27. -
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
Faizi, M., Bader, P. L., Saw, N., Nguyen, T.-V. V., Beraki, S., Wyss-Coray, T., … Shamloo, M. (2012). Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. BRAIN AND BEHAVIOR, 2(2), 142–54. -
Acute Administration of the Small-Molecule p75(NTR) Ligand Does Not Prevent Hippocampal Neuron Loss or Development of Spontaneous Seizures After Pilocarpine-Induced Status Epilepticus
Grabenstatter, H. L., Carlsen, J., Raol, Y. H., Yang, T., HUND, D., Del Angel, Y. C., … Brooks-Kayal, A. R. (2014). Acute Administration of the Small-Molecule p75(NTR) Ligand Does Not Prevent Hippocampal Neuron Loss or Development of Spontaneous Seizures After Pilocarpine-Induced Status Epilepticus. JOURNAL OF NEUROSCIENCE RESEARCH, 92(10), 1307–18. -
HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE
Sharp, F. R., Butman, M., Wang, S., Koistinaho, J., Graham, S. H., Sagar, S. M., … LONGO, F. M. (1993). HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE. Presented at the CONF ON MARKERS OF NEURONAL INJURY AND DEGENERATION, BETHESDA,MD: NEW YORK ACAD SCIENCES. -
NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM
MCKINLEY, M. P., LONGO, F. M., Valletta, J. S., Rahbar, F., NEVE, R. L., Prusiner, S. B., & Mobley, W. C. (1990). NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM. Presented at the SYMP ON MOLECULAR AND CELLULAR MECHANISMS OF NEURONAL PLASTICITY IN AGING AND ALZHEIMERS DISEASE, BETHESDA,MD: ELSEVIER SCIENCE PUBL B V. -
Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease.
Simmons, D. A., Longo, F. M., & Massa, S. M. (2016). Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease. CNS & Neurological Disorders Drug Targets, -? -
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Simmons, D. A., Belichenko, N. P., Ford, E. C., Semaan, S., Monbureau, M., Aiyaswamy, S., … Longo, F. M. (2016). A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics, 25(22), 4920–38. -
[F-18]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease
James, M. L., Belichenko, N. P., Shuhendler, A. J., Hoehne, A., Andrews, L. E., Condon, C., … Longo, F. M. (2017). [F-18]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease. THERANOSTICS, 7(6), 1422–36. -
Microglial complement receptor 3 regulates brain A beta levels through secreted proteolytic activity
Czirr, E., Castello, N. A., Mosher, K. I., Castellano, J. M., Hinkson, I. V., Lucin, K. M., … Wyss-Coray, T. (2017). Microglial complement receptor 3 regulates brain A beta levels through secreted proteolytic activity. JOURNAL OF EXPERIMENTAL MEDICINE, 214(4), 1081–92. -
Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts
Zbesko, J. C., Nguyen, T.-V. V., Yang, T., Frye, J. B., Hussain, O., Hayes, M., … Doyle, K. P. (2018). Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts. NEUROBIOLOGY OF DISEASE, 112, 63–78. -
Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons
Gu, F., Parada, I., Yang, T., Longo, F. M., & Prince, D. A. (2018). Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. NEUROBIOLOGY OF DISEASE, 113, 45–58. -
TSPO-PET Imaging Using [18F]PBR06 is a Potential Translatable Biomarker for Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31.
Simmons, D. A., James, M. L., Belichenko, N. P., Semaan, S., Condon, C., Kuan, J., … Longo, F. M. (2018). TSPO-PET Imaging Using [18F]PBR06 is a Potential Translatable Biomarker for Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31. Human Molecular Genetics. -
Unsolicited Patient Complaints Identify Physicians with Evidence of Neurocognitive Disorders
Cooper, W. O., Martinez, W., Domenico, H. J., Callahan, S. T., Kirkby, B. P., Finlayson, A. J. R., … Hickson, G. B. (2018). Unsolicited Patient Complaints Identify Physicians with Evidence of Neurocognitive Disorders. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 26(9), 927–36. -
A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.
Ali Shariati, M., Kumar, V., Yang, T., Chakraborty, C., Barres, B. A., Longo, F. M., & Liao, Y. J. (2018). A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy. Current Eye Research, 1–11. -
Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia
Nguyen, T.-V. V., Hayes, M., Zbesko, J. C., Frye, J. B., Congrove, N. R., Belichenko, N. P., … Doyle, K. P. (2018). Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 6, 100. -
Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.
Xie, Y., Meeker, R. B., Massa, S. M., & Longo, F. M. (2019). Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration. Scientific Reports, 9(1), 5273. -
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.
Wong, H. L., Qin, H.-Y., Tsang, S. W., Zuo, X., Che, S., Chow, C. F., … Bian, Z.-X. (2019). Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications, 10(1), 1745. -
Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1).
Boakye, P. A., Rancic, V., Whitlock, K. H., Simmons, D., Longo, F. M., Ballanyi, K., & Smith, P. A. (2019). Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1). Journal of Neurophysiology. -
A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice.
Li, W., Bellot-Saez, A., Phillips, M. L., Yang, T., Longo, F. M., & Pozzo-Miller, L. (2017). A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice. Disease Models & Mechanisms, 10(7), 837–45. -
Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis.
Meeker, R. B., Poulton, W., Clary, G., Schriver, M., & Longo, F. M. (2016). Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis. Experimental Neurology, 275 Pt 1, 182–98. -
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Longo, F. M., & Massa, S. M. (2013). Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nature Reviews. Drug Discovery, 12(7), 507–25. -
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Wong, H. L. X., Qin, H.-yan, Tsang, S. W., Zuo, X., Che, S., Chow, C. F. W., … Bian, Z.-xiang. (2019). Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. NATURE COMMUNICATIONS, 10. -
Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.
Elshaer, S. L., Alwhaibi, A., Mohamed, R., Lemtalsi, T., Coucha, M., Longo, F. M., & El-Remessy, A. B. (2019). Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. -
Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration
Xie, Y., Meeker, R. B., Massa, S. M., & Longo, F. M. (2019). Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration. SCIENTIFIC REPORTS, 9. -
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Geraghty, A. C., Gibson, E. M., Ghanem, R. A., Greene, J. J., Ocampo, A., Goldstein, A. K., … Monje, M. (2019). Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment. Neuron. -
Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.
Simmons, D. A., Lartey, F. M., Schüler, E., Rafat, M., King, G., Kim, A., … Loo, B. W. (2019). Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. -
Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor
Boakye, P. A., Rancic, V., Whitlock, K. H., Simmons, D., Longo, F. M., Ballanyi, K., & Smith, P. A. (2019). Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor. JOURNAL OF NEUROPHYSIOLOGY, 121(6), 2308–22. -
Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease
Mufson, E. J., Counts, S. E., Ginsberg, S. D., Mahady, L., Perez, S. E., Massa, S. M., … Ikonomovic, M. D. (2019). Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. FRONTIERS IN NEUROSCIENCE, 13. -
Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.
Mufson, E. J., Counts, S. E., Ginsberg, S. D., Mahady, L., Perez, S. E., Massa, S. M., … Ikonomovic, M. D. (2019). Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Frontiers in Neuroscience, 13, 533. -
Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway
Elshaer, S. L., Alwhaibi, A., Mohamed, R., Lemtalsi, T., Coucha, M., Longo, F. M., & El-Remessy, A. B. (2019). Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. DIABETOLOGIA, 62(8), 1488–1500. -
Methotrexate chemotherapy impairs adaptive myelination through altered BDNF-TrkB signaling
Geraghty, A. C., Gibson, E., Ghanem, R., Greene, J., Yang, T., Ni, L., … Monje, M. (2019). Methotrexate chemotherapy impairs adaptive myelination through altered BDNF-TrkB signaling. GLIA, 67, E329. -
TSPO-PET imaging using [F-18]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75(NTR) ligand LM11A-31
Simmons, D. A., James, M. L., Belichenko, N. P., Semaan, S., Condon, C., Kuan, J., … Longo, F. M. (2018). TSPO-PET imaging using [F-18]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75(NTR) ligand LM11A-31. HUMAN MOLECULAR GENETICS, 27(16), 2893–2912. -
Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
Wilson, E. N., Swarovski, M. S., Linortner, P., Shahid, M., Zuckerman, A. J., Wang, Q., … Andreasson, K. I. (2020). Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau. Brain : a Journal of Neurology. -
Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report
Gauthier, S., Aisen, P. S., Cummings, J., Detke, M. J., Longo, F. M., Raman, R., … Zoda, T. (2020). Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report. JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. -
Next-generation Alzheimer's Therapeutics: Leveraging Deep Biology
Longo, F. M., & Massa, S. M. (2020). Next-generation Alzheimer's Therapeutics: Leveraging Deep Biology. JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. -
Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.
Gu, F., Parada, I., Yang, T., Longo, F. M., & Prince, D. A. (2020). Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury. Cerebral Cortex (New York, N.Y. : 1991). -
Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020). Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice. Acta Neuropathologica Communications, 8(1), 156. -
Therapeutic Intervention of p75(NTR) With LM11A-31 Protects Against Systemic and Retinal Inflammation And Visual Impairment In A Model of Diabetic Retinopathy
El-Remessy, A. B., Mohamed, R., Pearson, L., & Longo, F. (2020). Therapeutic Intervention of p75(NTR) With LM11A-31 Protects Against Systemic and Retinal Inflammation And Visual Impairment In A Model of Diabetic Retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 61(7). -
Small molecule modulation of the p75 neurotrophin receptor suppresses age- and genotype-associated neurodegeneration in HIV gp120 transgenic mice.
Xie, Y., Seawell, J., Boesch, E., Allen, L., Suchy, A., Longo, F. M., & Meeker, R. B. (2020). Small molecule modulation of the p75 neurotrophin receptor suppresses age- and genotype-associated neurodegeneration in HIV gp120 transgenic mice. Experimental Neurology, 113489. -
Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.
Yang, T., Tran, K. C., Zeng, A. Y., Massa, S. M., & Longo, F. M. (2020). Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies. Scientific Reports, 10(1), 20322. -
Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury.
Yin, G. N., Ock, J., Limanjaya, A., Minh, N. N., Hong, S.-S. S., Yang, T., … Suh, J.-K. K. (2020). Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury. The Journal of Sexual Medicine. -
Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB
Adams, I., Yang, T., Longo, F. M., & Katz, D. M. (2020). Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB. DISEASE MODELS & MECHANISMS, 13(11). -
Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model.
Elshaer, S. L., Park, H.-S. S., Pearson, L., Hill, W. D., Longo, F. M., & El-Remessy, A. B. (2021). Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model. International Journal of Molecular Sciences, 22(2). -
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., … Andreasson, K. I. (2021). Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. -
Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31.
Fogle, J. E., Hudson, L., Thomson, A., Sherman, B., Gruen, M., Lacelles, B. D., … Meeker, R. B. (2021). Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31. Journal of Neurovirology. -
Establishing a Data Science Unit in an Academic Medical Center: An Illustrative Model.
Desai, M., Boulos, M., Pomann, G. M., Steinberg, G. K., Longo, F. M., Leonard, M., … Harrington, R. A. (2021). Establishing a Data Science Unit in an Academic Medical Center: An Illustrative Model. Academic Medicine : Journal of the Association of American Medical Colleges. -
Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31.
Simmons, D. A., Mills, B. D., Butler Iii, R. R., Kuan, J., McHugh, T. L., Akers, C., … Longo, F. M. (2021). Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. -
A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy
Shariati, M. A., Kumar, V., Yang, T., Chakraborty, C., Barres, B. A., Longo, F. M., & Liao, Y. J. (2018). A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy. CURRENT EYE RESEARCH, 43(12), 1489–1499. -
TrkB Neurotrophin Receptor Activation with Pharmacophore as Possible Treatment for Anterior Ischemic Optic Neuropathy
Liao, Y., Lee, G. H., Ma, J., Yang, T., Chakraborty, C., Barres, B., … Shariati, M. A. (2013). TrkB Neurotrophin Receptor Activation with Pharmacophore as Possible Treatment for Anterior Ischemic Optic Neuropathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
TrkB Neurotrophin Receptor Activation with Pharmacophore as Possible Treatment for Experimental Ischemic Optic Neuropathy
Shariati, M. A., Ma, J., Longo, F., Yang, T., Barres, B., Chakraborty, C., & Liao, Y. J. (2014). TrkB Neurotrophin Receptor Activation with Pharmacophore as Possible Treatment for Experimental Ischemic Optic Neuropathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand.
Killebrew, D. A., Williams, K. S., Xie, Y., Longo, F., & Meeker, R. B. (2021). Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand. Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. -
Modulation of p75(NTR) on Mesenchymal Stem Cells Improves Angiogenic Secretome and Vascular Protection in Retinal Ischemia-Reperfusion
El-Remessy, A. B., Elshaer, S., Park, H.-S., Pearson, L., Hill, W., & Longo, F. M. (2021). Modulation of p75(NTR) on Mesenchymal Stem Cells Improves Angiogenic Secretome and Vascular Protection in Retinal Ischemia-Reperfusion. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics.
He, Z., Le Guen, Y., Liu, L., Lee, J., Ma, S., Yang, A. C., … Ionita-Laza, I. (2021). Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics. American Journal of Human Genetics. -
Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.
Gonzalez, S., McHugh, T. L., Yang, T., Syriani, W., Massa, S. M., Longo, F. M., & Simmons, D. A. (2021). Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage. Neurobiology of Disease, 105563. -
Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery.
Nguyen, T.-V. V., Crumpacker, R. H., Calderon, K. E., Garcia, F. G., Zbesko, J. C., Frye, J. B., … Doyle, K. P. (2021). Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery. The Journal of Pharmacology and Experimental Therapeutics. -
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Gu, F., Parada, I., Yang, T., Longo, F. M., & Prince, D. A. (2022). Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome. Proceedings of the National Academy of Sciences of the United States of America, 119(7). -
Modulation of p75 neurotrophin receptor (p75NTR) with LM11A-31 improves neurovascular damage in diabetic stroke
Ismael, S., Longo, F., Bix, G., & Ishrat, T. (2022). Modulation of p75 neurotrophin receptor (p75NTR) with LM11A-31 improves neurovascular damage in diabetic stroke. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. SAGE PUBLICATIONS INC. -
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease.
Wilson, E. N., Young, C. B., Ramos Benitez, J., Swarovski, M. S., Feinstein, I., Vandijck, M., … Andreasson, K. I. (2022). Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease. Alzheimer's Research & Therapy, 14(1), 172. -
Editorial: Next-Generation Alzheimer's Therapeutics: Leveraging Deep Biology.
Longo, F. M., & Massa, S. M. (2020). Editorial: Next-Generation Alzheimer's Therapeutics: Leveraging Deep Biology. The Journal of Prevention of Alzheimer's Disease, 7(3), 138–139. -
Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report.
Gauthier, S., Aisen, P. S., Cummings, J., Detke, M. J., Longo, F. M., Raman, R., … Vellas, B. (2020). Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report. The Journal of Prevention of Alzheimer's Disease, 7(3), 152–157. -
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.
Iweka, C. A., Seigneur, E., Hernandez, A. L., Paredes, S. H., Cabrera, M., Blacher, E., … Andreasson, K. I. (2023). Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning. Journal of Neuroinflammation, 20(1), 48. -
Open drug discovery in Alzheimer's disease.
Axtman, A. D., Brennan, P. E., Frappier-Brinton, T., Betarbet, R., Carter, G. W., Fu, H., … Levey, A. I. (2023). Open drug discovery in Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.), 9(2), e12394. -
Neuroprotective effects of small, non-peptide neurotrophin mimetics in neural cultures challenged with gp120 or feline immunodeficiency virus
Meeker, R. B., Poulton, W., Feng, W., Massa, S. M., & Longo, F. M. (2007). Neuroprotective effects of small, non-peptide neurotrophin mimetics in neural cultures challenged with gp120 or feline immunodeficiency virus. JOURNAL OF NEUROVIROLOGY. TAYLOR & FRANCIS INC. -
Mechanisms of pain during development: Receptor protein tyrosine phosphatases.
Gonzalez-Brito, M., Bixby, J., & Longo, F. (2006). Mechanisms of pain during development: Receptor protein tyrosine phosphatases. CRITICAL CARE MEDICINE. LIPPINCOTT WILLIAMS & WILKINS. -
Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy
Simmons, D. A., Yang, T., Massa, S. M., & Longo, F. M. (2016). Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy. DEVELOPING THERAPEUTICS FOR ALZHEIMER'S DISEASE: PROGRESS AND CHALLENGES, 437–458. -
P75 NEUROTROPHIN RECEPTOR MODULATION AND JAK/STAT INHIBITION: ROLE IN THE PROGRESSION OF EPILEPSY IN THE PILOCARPINE RAT MODEL
Grabenstatter, H. L., Del Angel, C. Y., Carlsen, J., Yang, T., White, A. M., Longo, F. M., … Brooks-Kayal, A. R. (2013). P75 NEUROTROPHIN RECEPTOR MODULATION AND JAK/STAT INHIBITION: ROLE IN THE PROGRESSION OF EPILEPSY IN THE PILOCARPINE RAT MODEL. EPILEPSIA. WILEY-BLACKWELL. -
Role of RhoA in Cisplatin-Induced Neurotoxicity
Friesland, A. M., Duenas, M., Weng, Z., Longo, F. M., Chen, Y.-H., & Lu, Q. (2013). Role of RhoA in Cisplatin-Induced Neurotoxicity. FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL. -
Differential effects of cisplatin on lung cancer cells and primary neurons: roles of small GTPase RhoA
Weng, Z., Friesland, A., Lu, Z., Chen, Y.-H., Longo, F. M., Boykin, C., & Lu, Q. (2013). Differential effects of cisplatin on lung cancer cells and primary neurons: roles of small GTPase RhoA. FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL. -
Stabilizing intracellular calcium regulation with novel neurotrophin mimetics provides potent neuroprotection against gp120-induced macrophage toxins
Meeker, R. B., Poulton, W., Moore, L., Massa, S. M., & Longo, F. M. (2009). Stabilizing intracellular calcium regulation with novel neurotrophin mimetics provides potent neuroprotection against gp120-induced macrophage toxins. JOURNAL OF NEUROVIROLOGY. TAYLOR & FRANCIS INC. -
Neurotrophin Mimetics reverse effects of HIV gp120 on Macrophages and Microglia
Killebrew, D. A., Poulton, W., Longo, F. M., Massa, S. M., & Meeker, R. B. (2009). Neurotrophin Mimetics reverse effects of HIV gp120 on Macrophages and Microglia. JOURNAL OF NEUROVIROLOGY. TAYLOR & FRANCIS INC. -
Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease.
Simmons, D. A., Belichenko, N. P., & Longo, F. M. (2023). Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease. Journal of Huntington's Disease. -
Senolytic therapy for Alzheimer's disease.
Longo, F. M., & Massa, S. M. (2023). Senolytic therapy for Alzheimer's disease. Nature Medicine. -
Senolytic therapy for Alzheimer's disease
Longo, F. M., & Massa, S. M. (2023). Senolytic therapy for Alzheimer's disease. NATURE MEDICINE. -
Reduced expression of the cell intrinsic clock protein Bmal1 in myeloid cells accelerates cognitive decline and alters microglial function in aging mice
Iweka, C., Seigneur, E., Latif-Hernandez, A., Paredes, S. H., Cabrera, M., Blacher, E., … Andreasson, K. (2023). Reduced expression of the cell intrinsic clock protein Bmal1 in myeloid cells accelerates cognitive decline and alters microglial function in aging mice. MOLECULAR BIOLOGY OF THE CELL. AMER SOC CELL BIOLOGY. -
Delivery of BDNF through a Pluripotent Stem Cell-Based Platform Ameliorates Behavioral Deficits in a Mouse Model of Huntington's Disease
Selvaraj, S., Simmons, D. A., Chen, T., Cao, G. Y., Camelo, T. S., McHugh, T. L. M., … Porteus, M. H. (2023). Delivery of BDNF through a Pluripotent Stem Cell-Based Platform Ameliorates Behavioral Deficits in a Mouse Model of Huntington's Disease. MOLECULAR THERAPY. CELL PRESS. -
Targeting Endogenous Mechanisms of Brain Resilience for the Treatment and Prevention of Alzheimer's Disease.
Shanks, H. R., Onuska, K. M., Massa, S. M., Schmitz, T. W., & Longo, F. M. (2023). Targeting Endogenous Mechanisms of Brain Resilience for the Treatment and Prevention of Alzheimer's Disease. The Journal of Prevention of Alzheimer's Disease, 10(4), 699–705. -
Modulation of p75<SUP>NTR</SUP> on mesenchymal stem cells increases their vascular protection in retinal ischemia-reperfusion mouse model
Elshaer, S. L., Park, H.-soo, Pearson, L., Hill, W. D., Longo, F. M., & El-Remessy, A. B. (2023). Modulation of p75NTR on mesenchymal stem cells increases their vascular protection in retinal ischemia-reperfusion mouse model. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. MARY ANN LIEBERT, INC. -
Organ aging signatures in the plasma proteome track health and disease.
Oh, H. S.-H., Rutledge, J., Nachun, D., Pálovics, R., Abiose, O., Moran-Losada, P., … Wyss-Coray, T. (2023). Organ aging signatures in the plasma proteome track health and disease. Nature, 624(7990), 164–172. -
Modulation of the p75 neurotrophin receptor in the PS19 tauopathy mouse model regulates transcription profiles and inter-cellular communication across multiple populations of non-neuronal cells
Butler, R. R., Yang, T., Han, C., Le Guen, Y., Tran, K. C., Lallani, S., … Longo, F. M. (2023). Modulation of the p75 neurotrophin receptor in the PS19 tauopathy mouse model regulates transcription profiles and inter-cellular communication across multiple populations of non-neuronal cells. ALZHEIMERS & DEMENTIA. WILEY. -
Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains.
Cary, G. A., Wiley, J. C., Gockley, J., Keegan, S., Amirtha Ganesh, S. S., Heath, L., … Carter, G. W. (2024). Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains. Alzheimer's & Dementia (New York, N. Y.), 10(2), e12461. -
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
Latif-Hernandez, A., Yang, T., Raymond-Butler, R. 3rd, Losada, P. M., Minhas, P. S., White, H., … Longo, F. M. (2024). A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.
Medeiros, D., Ayala-Baylon, K., Egido-Betancourt, H., Miller, E., Chapleau, C., Robinson, H., … Pozzo-Miller, L. (2024). A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice. Disease Models & Mechanisms, 17(6). -
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas, P. S., Jones, J. R., Latif-Hernandez, A., Sugiura, Y., Durairaj, A. S., Wang, Q., … Andreasson, K. I. (2024). Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.), 385(6711), eabm6131. -
Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
Wilson, E., Umans, J., Swarovski, M., Minhas, P., Midttun, Ø., Ulvik, A. A., … Andreasson, K. (2024). Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction. Research Square.
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Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth
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