

Professional Summary
Education & Certifications
- Medical Education: Pritzker School of Medicine University of Chicago Registrar, 2003
- Residency: UCSF Dept of Internal Medicine, 2005
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Publications
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Cloning of a unique lipase from endothelial cells extends the lipase gene family
Hirata, K., Dichek, H. L., Cioffi, J. A., Choi, S. Y., Leeper, N. J., Quintana, L., … Quertermous, T. (1999). Cloning of a unique lipase from endothelial cells extends the lipase gene family. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(20), 14170–75. -
Gender does not influence outcomes after iliac angioplasty
Orr, J. D., Leeper, N. J., Funaki, B., Leef, J., Gewertz, B. L., & Desai, T. R. (2002). Gender does not influence outcomes after iliac angioplasty. ANNALS OF VASCULAR SURGERY, 16(1), 55–60. -
Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway
Desai, T. R., Leeper, N. J., Hynes, K. L., & Gewertz, B. L. (2002). Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway. JOURNAL OF SURGICAL RESEARCH, 104(2), 118–123. -
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Clinical problem-solving. One surprise after another.
Leeper, N. J., Wener, L. S., Dhaliwal, G., Saint, S., & Wachter, R. M. (2005). Clinical problem-solving. One surprise after another. New England Journal of Medicine, 352(14), 1474–1479. -
The effect of preoperative statin therapy on cardiovascular outcomes in patients undergoing infrainguinal vascular surgery
Ward, R. P., Leeper, N. J., Kirkpatrick, J. N., Lang, R. M., Sorrentino, M. J., & Williams, K. A. (2005). The effect of preoperative statin therapy on cardiovascular outcomes in patients undergoing infrainguinal vascular surgery. INTERNATIONAL JOURNAL OF CARDIOLOGY, 104(3), 264–268. -
Right coronary cameral fistula resulting from surgery of double chamber right ventricle.
Leeper, N. J., Gupta, A., Murphy, D. J., & Wu, J. C. (2006). Right coronary cameral fistula resulting from surgery of double chamber right ventricle. Journal of the American Society of Echocardiography , 19(9), 1191 e9–11. -
Clinical dilemmas in treating left ventricular thrombus.
Leeper, N. J., Gupta, A., Schnittger, I., & Wu, J. C. (2007). Clinical dilemmas in treating left ventricular thrombus. International Journal of Cardiology, 114(3), e118–9. -
Prognostic value of heart rate increase at onset of exercise testing
Leeper, N. J., Dewey, F. E., Ashley, E. A., Sandri, M., Tan, S. Y., Hadley, D., … Froelicher, V. (2007). Prognostic value of heart rate increase at onset of exercise testing. CIRCULATION, 115(4), 468–74. -
Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival
Leeper, N. J., Ardehali, R., DeGoma, E. M., & Heidenreich, P. A. (2007). Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival. CIRCULATION, 116(6), 613–18. -
Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol
deGoma, E. M., Leeper, N. J., & Heidenreich, P. A. (2008). Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(1), 49–55. -
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., Agrawal, R., … Quertermous, T. (2008). Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 118(10), 3343–54. -
Clinical problem-solving. Fool's Gold.
Leeper, N. J., Dhaliwal, G., Saint, S., & Witteles, R. M. (2008). Clinical problem-solving. Fool's Gold. New England Journal of Medicine, 359(19), 2035–41. -
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation
Leeper, N. J., Tedesco, M. M., Kojima, Y., Schultz, G. M., Kundu, R. K., Ashley, E. A., … Quertermous, T. (2009). Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296(5), H1329–H1335. -
Endogenous regulation of cardiovascular function by apelin-APJ
Charo, D. N., Ho, M., Fajardo, G., Kawana, M., Kundu, R. K., Sheikh, A. Y., … Quertermous, T. (2009). Endogenous regulation of cardiovascular function by apelin-APJ. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297(5), H1904–H1913. -
Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse
Kojima, Y., Kundu, R. K., Cox, C. M., Leeper, N. J., Anderson, J. A., Chun, H. J., … Quertermous, T. (2010). Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. CARDIOVASCULAR RESEARCH, 87(1), 156–65. -
Stem Cell Therapy for Vascular Regeneration Adult, Embryonic, and Induced Pluripotent Stem Cells
Leeper, N. J., Hunter, A. L., & Cooke, J. P. (2010). Stem Cell Therapy for Vascular Regeneration Adult, Embryonic, and Induced Pluripotent Stem Cells. CIRCULATION, 122(5), 517–26. -
MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Leeper, N. J., Raiesdana, A., Kojima, Y., Chun, H. J., Azuma, J., Maegdefessel, L., … Spin, J. M. (2011). MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function. JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1035–43. -
MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus
Leeper, N. J., & Cooke, J. P. (2011). MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus. CIRCULATION, 123(3), 236–38. -
Two Decades of Progress in Vascular Medicine
Leeper, N. J., Lee, J. T., & Cooke, J. P. (2011). Two Decades of Progress in Vascular Medicine. AMERICAN JOURNAL OF MEDICINE, 124(9), 791–92. -
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel, L., Azuma, J., Toh, R., Merk, D. R., Deng, A., Chin, J. T., … Tsao, P. S. (2012). Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. JOURNAL OF CLINICAL INVESTIGATION, 122(2), 497–506. -
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Maegdefessel, L., Azuma, J., Toh, R., Deng, A., Merk, D. R., Raiesdana, A., … Tsao, P. S. (2012). MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. SCIENCE TRANSLATIONAL MEDICINE, 4(122). -
Genetics of Peripheral Artery Disease
Leeper, N. J., Kullo, I. J., & Cooke, J. P. (2012). Genetics of Peripheral Artery Disease. CIRCULATION, 125(25), 3220–28. -
The Effect of Angiotensin-Converting Enzyme Inhibitors and Statins on the Progression of Aortic Sclerosis and Mortality
Ardehali, R., Leeper, N. J., Wilson, A. M., & Heidenreich, P. A. (2012). The Effect of Angiotensin-Converting Enzyme Inhibitors and Statins on the Progression of Aortic Sclerosis and Mortality. JOURNAL OF HEART VALVE DISEASE, 21(3), 337–43. -
Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease
Leeper, N. J., Myers, J., Zhou, M., Nead, K. T., Syed, A., Kojima, Y., … Cooke, J. P. (2013). Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. JOURNAL OF VASCULAR SURGERY, 57(3), 728–33. -
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., Maegdefessel, L., … Quertermous, T. (2013). Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(1), e1–e10. -
Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography
Nead, K. T., Zhou, M. J., Caceres, R. D., Sharp, S. J., Wehner, M. R., Olin, J. W., … Leeper, N. J. (2013). Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography. AMERICAN JOURNAL OF CARDIOLOGY, 111(6), 851–56. -
Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status.
Nead, K. T., Zhou, M., Caceres, R. D., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2013). Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status. Circulation. Cardiovascular Quality and Outcomes, 6(3), 255–61. -
Alternative Ankle-Brachial Index Method Identifies Additional At-Risk Individuals
Nead, K. T., Cooke, J. P., Olin, J. W., & Leeper, N. J. (2013). Alternative Ankle-Brachial Index Method Identifies Additional At-Risk Individuals. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(6), 553–59. -
Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes.
Leeper, N. J., Bauer-Mehren, A., Iyer, S. V., LePendu, P., Olson, C., & Shah, N. H. (2013). Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes. PloS One, 8(5). -
Tetracycline-regulatable expression vectors tightly regulate in vitro gene expression of secreted proteins
Sturtz, F. G., Cioffi, L., Wittmer, S., Sonk, M. J., Shafer, A., Li, Y. S., … Platika, D. (1998). Tetracycline-regulatable expression vectors tightly regulate in vitro gene expression of secreted proteins. GENE, 221(2), 279–285. -
Regulated expression of a unique lipase in endothelial cells suggests a local role in disease-associated lipid metabolism in the blood vessel wall
Hirata, K., Dichek, H. L., Choi, S. Y., Leeper, N. J., Cooper, A. D., & Quertermous, T. (1999). Regulated expression of a unique lipase in endothelial cells suggests a local role in disease-associated lipid metabolism in the blood vessel wall. CIRCULATION, 100(18), 610–610. -
Response to letter regarding article, "Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival"
Leeper, N. J., Ardehali, R., DeGoma, E. M., & Heidenreich, P. A. (2008). Response to letter regarding article, "Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival". CIRCULATION, 117(9), E175–E175. -
Microarray Analysis Identifies miRNA-26a as a Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation
Leeper, N. J., Raiesdana, A., Kojima, Y., Chun, H. J., Azuma, J., Kundu, R. K., … Spin, J. M. (2010). Microarray Analysis Identifies miRNA-26a as a Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11), E244–E244. -
Network Analysis Identifies the Orphan Receptor Tyrosine Kinase Ros1 as a Determinant of Glutathione Peroxidase-1 Mediated Vascular Remodeling
Ali, Z. A., Perez, V. D. J., Raiesdana, A., Leeper, N. J., Pan, S., Qu, X., … Ashley, E. A. (2011). Network Analysis Identifies the Orphan Receptor Tyrosine Kinase Ros1 as a Determinant of Glutathione Peroxidase-1 Mediated Vascular Remodeling. CIRCULATION, 124(21). -
Microrna-21 Regulates Expansion of Abdominal Aortic Aneurysms Through the PTEN/PI3K/AKT Pathway
Maegdefessel, L., Azuma, J., Deng, A., Toh, R. M., Merk, D. R., Raiesdana, A., … Tsao, P. S. (2011). Microrna-21 Regulates Expansion of Abdominal Aortic Aneurysms Through the PTEN/PI3K/AKT Pathway. CIRCULATION, 124(21). -
CDKN2B Regulates Cell Fate Decisions in Human Vascular Smooth Muscle Cells
Leeper, N. J., Raiesdana, A., Cheng, H., Kundu, R. K., Kojima, Y., Cheng, K., … Quertermous, T. (2010). CDKN2B Regulates Cell Fate Decisions in Human Vascular Smooth Muscle Cells. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
AN ALTERNATIVE ANKLE-BRACHIAL INDEX METHOD IDENTIFIES INDIVIDUALS AT HIGH-RISK FOR CARDIOVASCULAR MORTALITY THAT ARE CURRENTLY OVERLOOKED
Nead, K. T., Cooke, J. P., & Leeper, N. J. (2013). AN ALTERNATIVE ANKLE-BRACHIAL INDEX METHOD IDENTIFIES INDIVIDUALS AT HIGH-RISK FOR CARDIOVASCULAR MORTALITY THAT ARE CURRENTLY OVERLOOKED. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E2124–E2124. -
A hybrid genomic and proteomic biomarker panel accurately predicts peripheral arterial disease status
Nead, K. T., Putnam, K., Cooke, J. P., Olin, J. W., & Leeper, N. J. (2013). A hybrid genomic and proteomic biomarker panel accurately predicts peripheral arterial disease status. VASCULAR MEDICINE, 18(3), 165–165. -
Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease
Zhou, M., Leeper, N. J., Nead, K. T., Syed, A., Abella, J., Kojima, Y., … Myers, J. (2012). Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. VASCULAR MEDICINE, 17(3), 204–5. -
The Role of CDKN2B in Vascular Disease
Cheng, H. G., Leeper, N. J., Raisedana, A., Kundu, R., Kojima, Y., & Quertermous, T. (2010). The Role of CDKN2B in Vascular Disease. CIRCULATION, 122(21). -
Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nürnberg, S. T., Diaz, R., … Quertermous, T. (2013). Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genetics, 9(7). -
The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model.
Downing, K. P., Nead, K. T., Kojima, Y., Assimes, T., Maegdefessel, L., Quertermous, T., … Leeper, N. J. (2014). The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. Vascular Medicine , 19(1), 3–8. -
Network analysis of unstructured EHR data for clinical research.
Bauer-Mehren, A., LePendu, P., Iyer, S. V., Harpaz, R., Leeper, N. J., & Shah, N. H. (2013). Network analysis of unstructured EHR data for clinical research. AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science, 2013, 14–18. -
Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden.
Priest, J. R., Nead, K. T., Wehner, M. R., Cooke, J. P., & Leeper, N. J. (2014). Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. PloS One, 9(2). -
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., … Leeper, N. J. (2014). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 124(3), 1083–1097. -
Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8
Ahn, G.-O., Seita, J., Hong, B.-J., Kim, Y.-E., Bok, S., Lee, C.-J., … Brown, J. M. (2014). Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2698–2703. -
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., … Sczakiel, G. (2014). Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genetics, 10(3). -
Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., Diaz, R., … Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7). -
Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., Maegdefessel, L., … Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-? -
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., … Sczakiel, G. (2014). Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genetics, 10(3). -
Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes.
Leeper, N. J., Bauer-Mehren, A., Iyer, S. V., LePendu, P., Olson, C., & Shah, N. H. (2013). Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes. PloS One, 8(5). -
Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden.
Priest, J. R., Nead, K. T., Wehner, M. R., Cooke, J. P., & Leeper, N. J. (2014). Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. PloS One, 9(2). -
Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis.
Morris, D. R., Rodriguez, A. J., Moxon, J. V., Cunningham, M. A., McDermott, M. M., Myers, J., … Golledge, J. (2014). Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis. Journal of the American Heart Association, 3(4). -
Clinical and socioeconomic factors associated with unrecognized peripheral artery disease
Chang, P., Nead, K. T., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2014). Clinical and socioeconomic factors associated with unrecognized peripheral artery disease. VASCULAR MEDICINE, 19(4), 289–96. -
Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1
Ali, Z. A., Perez, V. D. J., Yuan, K., Orcholski, M., Pan, S., Qi, W., … Ashley, E. A. (2014). Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. JOURNAL OF CLINICAL INVESTIGATION, 124(12), 5159–74. -
Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells
Perin, E. C., Murphy, M., Cooke, J. P., Moye, L., Henry, T. D., Bettencourt, J., … Hirsch, A. T. (2014). Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells. AMERICAN HEART JOURNAL, 168(5), 667–73. -
MicroRNA Regulation of Vascular Smooth Muscle Function and Phenotype Early Career Committee Contribution
Maegdefessel, L., Rayner, K. J., & Leeper, N. J. (2015). MicroRNA Regulation of Vascular Smooth Muscle Function and Phenotype Early Career Committee Contribution. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(1), 2–6. -
Effect of physical activity assessment on prognostication for peripheral artery disease and mortality.
Chang, P., Nead, K. T., Olin, J. W., Myers, J., Cooke, J. P., & Leeper, N. J. (2015). Effect of physical activity assessment on prognostication for peripheral artery disease and mortality. Mayo Clinic Proceedings, 90(3), 339–45. -
Improved Reclassification of Mortality Risk by Assessment of Physical Activity in Patients Referred for Exercise Testing
Myers, J., Nead, K. T., Chang, P., Abella, J., Kokkinos, P., & Leeper, N. J. (2015). Improved Reclassification of Mortality Risk by Assessment of Physical Activity in Patients Referred for Exercise Testing. AMERICAN JOURNAL OF MEDICINE, 128(4), 396–402. -
Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population.
Shah, N. H., LePendu, P., Bauer-Mehren, A., Ghebremariam, Y. T., Iyer, S. V., Marcus, J., … Leeper, N. J. (2015). Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PloS One, 10(6). -
The Genetic Basis of Peripheral Arterial Disease Current Knowledge, Challenges, and Future Directions
Kullo, I. J., & Leeper, N. J. (2015). The Genetic Basis of Peripheral Arterial Disease Current Knowledge, Challenges, and Future Directions. CIRCULATION RESEARCH, 116(9), 1551–1560. -
Proton pump inhibitors and vascular function: A prospective cross-over pilot study
Ghebremariam, Y. T., Cooke, J. P., Khan, F., Thakker, R. N., Chang, P., Shah, N. H., … Leeper, N. J. (2015). Proton pump inhibitors and vascular function: A prospective cross-over pilot study. VASCULAR MEDICINE, 20(4), 309–16. -
Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population
Shah, N. H., LePendu, P., Bauer-Mehren, A., Ghebremariam, Y. T., Iyer, S. V., Marcus, J., … Leeper, N. J. (2015). Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PLOS ONE, 10(6). -
Rationale and design for PACE: patients with intermittent claudication injected with ALDH bright cells.
Perin, E. C., Murphy, M., Cooke, J. P., Moyé, L., Henry, T. D., Bettencourt, J., … Hirsch, A. T. (2014). Rationale and design for PACE: patients with intermittent claudication injected with ALDH bright cells. American Heart Journal, 168(5), 667–73. -
CDKN2B Regulates TGFß Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.
Nanda, V., Downing, K. P., Ye, J., Xiao, S., Kojima, Y., Spin, J. M., … Leeper, N. J. (2016). CDKN2B Regulates TGFß Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels. Circulation Research, 118(2), 230–40. -
Reply.
Shah, N. H., Cooke, J. P., & Leeper, N. J. (2016). Reply. Gastroenterology, 150(2), 528-? -
Androgen Deprivation Therapy and Future Alzheimer's Disease Risk.
Nead, K. T., Gaskin, G., Chester, C., Swisher-McClure, S., Dudley, J. T., Leeper, N. J., & Shah, N. H. (2016). Androgen Deprivation Therapy and Future Alzheimer's Disease Risk. Journal of Clinical Oncology , 34(6), 566–71. -
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., … Leeper, N. J. (2016). CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature, 536(7614), 86–90. -
Statin Intensity or Achieved LDL? Practice-based Evidence for the Evaluation of New Cholesterol Treatment Guidelines
Ross, E. G., Shah, N., & Leeper, N. (2016). Statin Intensity or Achieved LDL? Practice-based Evidence for the Evaluation of New Cholesterol Treatment Guidelines. PLOS ONE, 11(5). -
One surprise after another
Leeper, N. J., Wener, L. S., Dhaliwal, G., Saint, S., & Wachter, R. M. (2005). One surprise after another. NEW ENGLAND JOURNAL OF MEDICINE, 352(14), 1474–1479. -
The use of machine learning for the identification of peripheral artery disease and future mortality risk.
Ross, E. G., Shah, N. H., Dalman, R. L., Nead, K. T., Cooke, J. P., & Leeper, N. J. (2016). The use of machine learning for the identification of peripheral artery disease and future mortality risk. Journal of Vascular Surgery, 64(5), 1515–22 e3. -
Influence of age on androgen deprivation therapy-associated Alzheimer's disease
Nead, K. T., Gaskin, G., Chester, C., Swisher-McClure, S., Dudley, J. T., Leeper, N. J., & Shah, N. H. (2016). Influence of age on androgen deprivation therapy-associated Alzheimer's disease. SCIENTIFIC REPORTS, 6. -
Association Between Androgen Deprivation Therapy and Risk of Dementia.
Nead, K. T., Gaskin, G., Chester, C., Swisher-McClure, S., Leeper, N. J., & Shah, N. H. (2016). Association Between Androgen Deprivation Therapy and Risk of Dementia. JAMA Oncology. -
High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
Leeper, N. J., Park, S.-min, & Smith, B. R. (2017). High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease. JACC: Basic to Translational Science, 2(1). -
The Role of Efferocytosis in Atherosclerosis
Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017). The Role of Efferocytosis in Atherosclerosis. CIRCULATION, 135(5), 476–89. -
Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study
Venkatesh, B. A., Nauffal, V., Noda, C., Fujii, T., Yang, P. C., Bettencourt, J., … Lima, J. A. C. (2017). Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study. AMERICAN HEART JOURNAL, 183, 24–34. -
"Attack of the Clones": Commonalities Between Cancer and Atherosclerosis.
DiRenzo, D., Owens, G. K., & Leeper, N. J. (2017). "Attack of the Clones": Commonalities Between Cancer and Atherosclerosis. Circulation Research, 120(4), 624–26. -
Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial.
Perin, E. C., Murphy, M. P., March, K. L., Bolli, R., Loughran, J., Yang, P. C., … Hirsch, A. T. (2017). Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial. Circulation. -
Association Between Androgen Deprivation Therapy and Risk of Dementia
Nead, K. T., Gaskin, G., Chester, C., Swisher-McClure, S., Leeper, N. J., & Shah, N. H. (2017). Association Between Androgen Deprivation Therapy and Risk of Dementia. JAMA ONCOLOGY, 3(1), 49–55. -
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
Betancur, P. A., Abraham, B. J., Yiu, Y. Y., Willingham, S. B., Khameneh, F., Zarnegar, M., … Weissman, I. L. (2017). A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. NATURE COMMUNICATIONS, 8. -
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken, S. M., Jin, H., Chernogubova, E., Li, Y., Simon, N., Sun, C., … Maegdefessel, L. (2017). MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. CIRCULATION RESEARCH, 120(4), 633-? -
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.
Neal, B., Perkovic, V., Mahaffey, K. W., de Zeeuw, D., Fulcher, G., Erondu, N., … Matthews, D. R. (2017). Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. The New England Journal of Medicine, 377(7), 644–57. -
The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications.
Youssef, A. A., Ross, E. G., Bolli, R., Pepine, C. J., Leeper, N. J., & Yang, P. C. (2016). The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC. Basic to Translational Science, 1(6), 510–23. -
Proefferocytic Therapy Promotes Transforming Growth Factor-beta Signaling and Prevents Aneurysm Formation
Kojima, Y., Werner, N., Ye, J., Nanda, V., Tsao, N., Wang, Y., … Leeper, N. J. (2018). Proefferocytic Therapy Promotes Transforming Growth Factor-beta Signaling and Prevents Aneurysm Formation. CIRCULATION, 137(7), 750–53. -
Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease
Leeper, N. J., & Maegdefessel, L. (2018). Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease. CARDIOVASCULAR RESEARCH, 114(4), 611–21. -
Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council
Robinet, P., Milewicz, D. M., Cassis, L. A., Leeper, N. J., Lu, H. S., & Smith, J. D. (2018). Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(2), 292–303. -
Association of Blood Pressure Measurements with Peripheral Arterial Disease Events: A Reanalysis of the ALLHAT Data.
Itoga, N. K., Tawfik, D. S., Lee, C. K., Maruyama, S., Leeper, N. J., & Chang, T. I. (2018). Association of Blood Pressure Measurements with Peripheral Arterial Disease Events: A Reanalysis of the ALLHAT Data. Circulation. -
Clinical and genetic determinants of varicose veins: a prospective, community-based prospective study of similar to 500,000 individuals
Fukaya, E., Flores, A., Lindholm, D., Gustafsson, S., Ingelsson, E., & Leeper, N. (2018). Clinical and genetic determinants of varicose veins: a prospective, community-based prospective study of similar to 500,000 individuals. VASCULAR MEDICINE, 23(3), 300. -
Use of Predictive Analytics for the Identification of Latent Vascular Disease and Future Adverse Cardiac Events
Ross, E. G., Shah, N., Dalman, R. L., Nead, K., & Leeper, N. J. (2016). Use of Predictive Analytics for the Identification of Latent Vascular Disease and Future Adverse Cardiac Events. JOURNAL OF VASCULAR SURGERY. MOSBY-ELSEVIER. -
Use of Machine Learning to Accurately Predict Adverse Events in Patients with Peripheral Artery Disease Using Electronic Health Record Data
Ross, E. G., Shah, N., & Leeper, N. (2016). Use of Machine Learning to Accurately Predict Adverse Events in Patients with Peripheral Artery Disease Using Electronic Health Record Data. VASCULAR MEDICINE. SAGE PUBLICATIONS LTD. -
Trends in Rates of Lower Extremity Amputation Among Patients With End-Stage Renal Disease Who Receive Dialysis
Franz, D., Zheng, Y., Leeper, N. J., Chandra, V., Montez-Rath, M., & Chang, T. I. (2018). Trends in Rates of Lower Extremity Amputation Among Patients With End-Stage Renal Disease Who Receive Dialysis. JAMA Internal Medicine. -
Thrombotic Regulation From the Endothelial Cell Perspectives
Wang, M., Hao, H., Leeper, N. J., & Zhu, L. (2018). Thrombotic Regulation From the Endothelial Cell Perspectives. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(6), E90–E95. -
Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation
Scruggs, A. M., Koh, H. B., Tripathi, P., Leeper, N. J., White, E. S., & Huang, S. K. (2018). Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 59(2), 200–214. -
The Walking Impairment Questionnaire Predicts Total and Cardiovascular Mortality Independent of Peripheral Artery Disease Status
Nead, K. T., Zhou, M., Diaz-Caceres, R., Roberts, S. E., Lee, W. L., Phan, N. H., … Leeper, N. J. (2012). The Walking Impairment Questionnaire Predicts Total and Cardiovascular Mortality Independent of Peripheral Artery Disease Status. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.
Nanda, V., Wang, T., Pjanic, M., Liu, B., Nguyen, T., Matic, L. P., … Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLoS Genetics, 14(11), e1007755. -
Clinical and Genetic Determinants of Varicose Veins.
Fukaya, E., Flores, A. M., Lindholm, D., Gustafsson, S., Zanetti, D., Ingelsson, E., & Leeper, N. J. (2018). Clinical and Genetic Determinants of Varicose Veins. Circulation, 138(25), 2869–80. -
Bioimpedance and New-Onset Heart Failure: A Longitudinal Study of >500 000 Individuals From the General Population
Lindholm, D., Fukaya, E., Leeper, N. J., & Ingelsson, E. (2018). Bioimpedance and New-Onset Heart Failure: A Longitudinal Study of >500 000 Individuals From the General Population. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(13). -
Smooth muscle cells contribute the majority of foam cells in apolipoprotein E-deficient mouse atherosclerosis
Wang, Y., Dubland, J., Allahverdian, S., Asonye, E., Sahin, B., Jaw, J. E., … Francis, G. (2019). Smooth muscle cells contribute the majority of foam cells in apolipoprotein E-deficient mouse atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology (In Press), 876–87. -
Nanoparticle Therapy for Vascular Diseases.
Flores, A. M., Ye, J., Jarr, K.-U., Hosseini-Nassab, N., Smith, B. R., & Leeper, N. J. (2019). Nanoparticle Therapy for Vascular Diseases. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA118311569. -
Predicting Future Cardiovascular Events in Patients With Peripheral Artery Disease Using Electronic Health Record Data.
Ross, E. G., Jung, K., Dudley, J. T., Li, L., Leeper, N. J., & Shah, N. H. (2019). Predicting Future Cardiovascular Events in Patients With Peripheral Artery Disease Using Electronic Health Record Data. Circulation. Cardiovascular Quality and Outcomes, 12(3), e004741. -
Apelin Prevents Aortic Aneurysm Formation by Inhibiting Macrophage Inflammation and Infiltration
Leeper, N. J., Tedesco, M. M., Kojima, Y., Schultz, G., Ho, M. Y., Kundu, R. K., … Quedermous, T. (2008). Apelin Prevents Aortic Aneurysm Formation by Inhibiting Macrophage Inflammation and Infiltration. CIRCULATION, 118(18), S451. -
Clinical significance of HDL-c levels among patients with LDL-c less than 60 mg/dl
deGoma, E., Leeper, N. J., & Heidenreich, P. A. (2006). Clinical significance of HDL-c levels among patients with LDL-c less than 60 mg/dl. CIRCULATION, 114(18), 899. -
Statin use in patients with extremely low LDL levels is associated with improved survival
Leeper, N. J., Ardehali, R., DeGoma, E. M., & Heidenreich, P. A. (2006). Statin use in patients with extremely low LDL levels is associated with improved survival. CIRCULATION, 114(18), 827–28. -
Administration of ALDH Bright Cells to Patients With Intermittent Claudication: The NHLBI CCTRN PACE Trial
Perin, E. C., Murphy, M., March, K., Bolli, R., Leeper, N. J., Yang, P. C., … Hirsch, A. T. (2016). Administration of ALDH Bright Cells to Patients With Intermittent Claudication: The NHLBI CCTRN PACE Trial. CIRCULATION, 134(25), E709. -
The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.
Nanda, V., Xiao, S., Ye, J., & Leeper, N. J. (2017). The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis. JACC. Basic to Translational Science, 2(2), 209–11. -
MiRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken, S. M., Jin, H., Chernogubova, E., Li, Y., Simon, N., Sun, C., … Maegdefessel, L. (2017). MiRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. -
A Missing LNC in Vascular Diseases
Cooke, J. P., & Leeper, N. J. (2017). A Missing LNC in Vascular Diseases. CIRCULATION RESEARCH, 121(4), 320–22. -
Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis.
Miller, C. L., & Leeper, N. J. (2016). Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis. JACC. Basic to Translational Science, 1(7), 680–83. -
The role of necroptosis in atherosclerotic disease.
Leeper, N. J. (2016). The role of necroptosis in atherosclerotic disease. JACC. Basic to Translational Science, 1(6), 548–50. -
Text-mining methods applied to clinical records support an association between androgen deprivation therapy and subsequent cardiometabolic disease
Nead, K. T., Gaskin, G. L., Chester, C., Shah, N. H., & Leeper, N. J. (2015). Text-mining methods applied to clinical records support an association between androgen deprivation therapy and subsequent cardiometabolic disease. CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
Using clinical data text-mining analysis to examine the association between androgen deprivation therapy and depression.
Nead, K. T., Gaskin, G. L., Chester, C., Leeper, N. J., & Shah, N. H. (2015). Using clinical data text-mining analysis to examine the association between androgen deprivation therapy and depression. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease
Hamburg, N. M., & Leeper, N. J. (2015). Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease. CURRENT VASCULAR PHARMACOLOGY, 13(3), 316–23. -
What Matters Most, Statin Intensity or Achieved LDL? - Evaluating Concordance of AHA/ACC Guidelines for Statin Use with Practice Outcomes at Stanford Hospital & Clinics
Gyang, E., Shah, N., & Leeper, N. (2015). What Matters Most, Statin Intensity or Achieved LDL? - Evaluating Concordance of AHA/ACC Guidelines for Statin Use with Practice Outcomes at Stanford Hospital & Clinics. VASCULAR MEDICINE. SAGE PUBLICATIONS LTD. -
Cyclin-Dependent Kinase Inhibitor 2B Regulates Transforming Growth Factor Beta 1 Mediated Smooth Muscle Cell Recruitment to Ischemic Blood Vessels
Nanda, V., Downing, K., Kojima, Y., DiRenzo, D., Dalman, J., Connolly, A. J., … Leeper, N. (2015). Cyclin-Dependent Kinase Inhibitor 2B Regulates Transforming Growth Factor Beta 1 Mediated Smooth Muscle Cell Recruitment to Ischemic Blood Vessels. VASCULAR MEDICINE, 20(3), 274. -
Socioeconomic Barriers to the Diagnosis of Peripheral Arterial Disease
Chang, P., Nead, K. T., Thakker, R., Cooke, J. P., Olin, J. W., & Leeper, N. J. (2013). Socioeconomic Barriers to the Diagnosis of Peripheral Arterial Disease. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
Apelin Modulates Adipocyte and Inflammatory Cell Processes to Inhibit Atherosclerosis
Kojima, Y., Kundu, R., Leeper, N. J., Chun, H. J., & Quertermous, T. (2009). Apelin Modulates Adipocyte and Inflammatory Cell Processes to Inhibit Atherosclerosis. CIRCULATION, 120(18), S1064. -
Apelin Regulates Vascular Remodeling In The Mouse Carotid Artery Ligation Model
Kojima, Y., Kundu, R., Leeper, N. J., Anderson, J., & Quertermous, T. (2008). Apelin Regulates Vascular Remodeling In The Mouse Carotid Artery Ligation Model. CIRCULATION, 118(18), S574. -
Atherosclerosis Development is Increased in Apelin/Apoe Double Knockout Mice
Kojima, Y., Kundu, R., Leeper, N. J., & Quortermous, T. (2008). Atherosclerosis Development is Increased in Apelin/Apoe Double Knockout Mice. CIRCULATION, 118(18), S481. -
Clinical and socioeconomic factors associated with unrecognized peripheral artery disease.
Chang, P., Nead, K. T., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2014). Clinical and socioeconomic factors associated with unrecognized peripheral artery disease. Vascular Medicine (London, England), 19(4), 289–296. -
Trends in Rates of Lower Extremity Amputation Among Patients With End-stage Renal Disease Who Receive Dialysis.
Franz, D., Zheng, Y., Leeper, N. J., Chandra, V., Montez-Rath, M., & Chang, T. I. (2018). Trends in Rates of Lower Extremity Amputation Among Patients With End-stage Renal Disease Who Receive Dialysis. JAMA Internal Medicine. -
Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease.
Berger, A., Simpson, A., Bhagnani, T., Leeper, N. J., Murphy, B., Nordstrom, B., … Berger, J. S. (2019). Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease. The American Journal of Cardiology. -
Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis.
Wang, Y., Dubland, J. A., Allahverdian, S., Asonye, E., Sahin, B., Jaw, J. E., … Francis, G. A. (2019). Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(5), 876–887. -
High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease.
Leeper, N. J., Park, S.-M. M., & Smith, B. R. (2017). High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease. JACC. Basic to Translational Science, 2(1), 98–100. -
Clinical and Genetic Determinants of Varicose Veins Prospective, Community-Based Study of approximate to 500 000 Individuals
Fukaya, E., Flores, A. M., Lindholm, D., Gustafsson, S., Zanetti, D., Ingelsson, E., & Leeper, N. J. (2018). Clinical and Genetic Determinants of Varicose Veins Prospective, Community-Based Study of approximate to 500 000 Individuals. CIRCULATION, 138(25), 2869–80. -
Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease.
Wang, Y., Nanda, V., & Leeper, N. J. (2019). Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(6), 982–83. -
Predicting Future Cardiovascular Events in Patients With Peripheral Artery Disease Using Electronic Health Record Data
Ross, E. G., Jung, K., Dudley, J. T., Li, L., Leeper, N. J., & Shah, N. H. (2019). Predicting Future Cardiovascular Events in Patients With Peripheral Artery Disease Using Electronic Health Record Data. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 12(3). -
A Comprehensive Evaluation of Lifestyle and Social Factors Related to Peripheral Artery Disease Events in a Large Longitudinal Study
Ross, E., Leeper, N., & Ingelsson, E. (2019). A Comprehensive Evaluation of Lifestyle and Social Factors Related to Peripheral Artery Disease Events in a Large Longitudinal Study. JOURNAL OF VASCULAR SURGERY, 69(6), E54–E55. -
Resolvin D1 promotes the targeting and clearance of necroptotic cells.
Gerlach, B. D., Marinello, M., Heinz, J., Rymut, N., Sansbury, B. E., Riley, C. O., … Fredman, G. (2019). Resolvin D1 promotes the targeting and clearance of necroptotic cells. Cell Death and Differentiation. -
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus
Nanda, V., Wang, T., Pjanic, M., Liu, B., Trieu Nguyen, Matic, L. P., … Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLOS GENETICS, 14(11). -
Association of Blood Pressure Measurements With Peripheral Artery Disease Events: Reanalysis of the ALLHAT Data
Itoga, N. K., Tawfik, D. S., Lee, C. K., Maruyama, S., Leeper, N. J., & Chang, T. I. (2018). Association of Blood Pressure Measurements With Peripheral Artery Disease Events: Reanalysis of the ALLHAT Data. CIRCULATION, 138(17), 1805–14. -
Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease
Berger, A., Simpson, A., Bhagnani, T., Leeper, N. J., Murphy, B., Nordstrom, B., … Berger, J. S. (2019). Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease. AMERICAN JOURNAL OF CARDIOLOGY, 123(12), 1893–99. -
Nanoparticle Therapy for Vascular Diseases
Flores, A. M., Ye, J., Jarr, K.-U., Hosseini-Nassab, N., Smith, B. R., & Leeper, N. J. (2019). Nanoparticle Therapy for Vascular Diseases. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(4), 635–46. -
Real-World Predictors of Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients with Chronic Coronary Artery Disease and/or Peripheral Arterial Disease.
Berger, A., Simpson, A., Leeper, N., Murphy, B., Nordstrom, B., Ting, W., … Berger, J. (2019). Real-World Predictors of Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients with Chronic Coronary Artery Disease and/or Peripheral Arterial Disease. Advances in Therapy. -
Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.
Flores, A. M., Hosseini-Nassab, N., Jarr, K.-U. U., Ye, J., Zhu, X., Wirka, R., … Leeper, N. J. (2020). Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis. Nature Nanotechnology. -
Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis.
Kojima, Y., Ye, J., Nanda, V., Wang, Y., Flores, A. M., Jarr, K.-U., … Leeper, N. J. (2020). Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis. Circulation, 141(15), 1274–76. -
Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.
Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences of the United States of America. -
Identifying dietary and nutritional risk factors for symptomatic peripheral arterial disease using the UK biobank cohort study
Kaufman, A., Fukaya, E., Leeper, N., & Ross, E. (2020). Identifying dietary and nutritional risk factors for symptomatic peripheral arterial disease using the UK biobank cohort study. VASCULAR MEDICINE, 25(3), NP5. -
Toward Automated Detection of Peripheral Artery Disease Using Electronic Health Records
Vy Thuy Ho, Leeper, N., Shah, N., & Ross, E. (2020). Toward Automated Detection of Peripheral Artery Disease Using Electronic Health Records. JOURNAL OF VASCULAR SURGERY, 72(1), E41. -
The impact of low-dose anticoagulation therapy on peripheral artery disease: insights from the VOYAGER trial.
Fukaya, E., & Leeper, N. J. (2020). The impact of low-dose anticoagulation therapy on peripheral artery disease: insights from the VOYAGER trial. Cardiovascular Research, 116(12), e156–e158. -
18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease.
Jarr, K.-U., Ye, J., Kojima, Y., Nanda, V., Flores, A. M., Tsantilas, P., … Leeper, N. J. (2020). 18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA120315239. -
Incentivizing physical activity through activity monitoring interventions in PAD - a pilot study.
Fukaya, E., Welden, S., Bukari, A., Khan, Z., Leeper, N., & Mohler, E. (2020). Incentivizing physical activity through activity monitoring interventions in PAD - a pilot study. VASA. Zeitschrift Fur Gefasskrankheiten, 1–6. -
Macrophage-targeted single walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release
Zhang, Y., Ye, J., Hosseini-Nassab, N., Flores, A., Kalashnikova, I., Paluri, S. L., … Smith, B. R. (2020). Macrophage-targeted single walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release. NANO RESEARCH. -
Intradialytic Hypotension and Newly Recognized Peripheral Artery Disease in Patients Receiving Hemodialysis.
Seong, E. Y., Liu, S., Song, S. H., Leeper, N. J., Winkelmayer, W. C., Montez-Rath, M. E., & Chang, T. I. (2020). Intradialytic Hypotension and Newly Recognized Peripheral Artery Disease in Patients Receiving Hemodialysis. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. -
Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability.
Tsantilas, P., Lao, S., Wu, Z., Eberhard, A., Winski, G., Vaerst, M., … Leeper, N. J. (2021). Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability. Cardiovascular Research. -
Effect of CD47 Blockade on Vascular Inflammation.
Jarr, K.-U. U., Nakamoto, R., Doan, B. H., Kojima, Y., Weissman, I. L., Advani, R. H., … Leeper, N. J. (2021). Effect of CD47 Blockade on Vascular Inflammation. The New England Journal of Medicine, 384(4), 382–83. -
2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions)
Creager, M. A., Hamburg, N. M., Calligaro, K. D., Casanegra, A., Freeman, R., Gordon, P. A., … Weitz, H. H. (2021). 2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions). VASCULAR MEDICINE, 91–112. -
2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions)
Creager, M. A., Hamburg, N. M., Calligaro, K. D., Casanegra, A., Freeman, R., Gordon, P. A., … Williams, M. S. (2021). 2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 77(7), 998–1020. -
US National Trends in Vascular Surgical Practice During the COVID-19 Pandemic.
Ho, V. T., Eberhard, A. V., Asch, S. M., Leeper, N. J., Fukaya, E., Arya, S., & Ross, E. G. (2021). US National Trends in Vascular Surgical Practice During the COVID-19 Pandemic. JAMA Surgery. -
2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions) A Report of the ACC Competency Management Committee
Creager, M. A., Hamburg, N. M., Calligaro, K. D., Casanegra, A., Freeman, R., Gordon, P. A., … Williams, M. S. (2021). 2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions) A Report of the ACC Competency Management Committee. CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 14(2), e000079. -
Comparison of Pre-Amputation Evaluation in Patients with and without Chronic Kidney Disease.
Subramanian, N., Han, J., Leeper, N. J., Ross, E. G., Montez-Rath, M. E., & Chang, T. I. (2021). Comparison of Pre-Amputation Evaluation in Patients with and without Chronic Kidney Disease. American Journal of Nephrology, 1–8. -
Peripheral Vascular Disease in 2021.
Leeper, N. J., & Hamburg, N. M. (2021). Peripheral Vascular Disease in 2021. Circulation Research, 128(12), 1803–1804. -
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes.
Flores, A. M., Demsas, F., Leeper, N. J., & Ross, E. G. (2021). Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes. Circulation Research, 128(12), 1833–1850. -
Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease.
Alsaigh, T., Di Bartolo, B. A., Mulangala, J., Figtree, G. A., & Leeper, N. J. (2021). Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease. Circulation Research, 128(12), 1927–1943. -
Ultraselective Carbon Nanotubes for Photoacoustic Imaging of Inflamed Atherosclerotic Plaques
Gifani, M., Eddins, D. J., Kosuge, H., Zhang, Y., Paluri, S. L. A., Larson, T., … Smith, B. R. (2021). Ultraselective Carbon Nanotubes for Photoacoustic Imaging of Inflamed Atherosclerotic Plaques. ADVANCED FUNCTIONAL MATERIALS. -
Reduction in Acute Limb Ischemia with Rivaroxaban versus Placebo in Peripheral Artery Disease after Lower Extremity Revascularization: Insights from VOYAGER PAD.
Hess, C. N., Debus, E. S., Nehler, M. R., Anand, S. S., Patel, M. R., Szarek, M., … Bonaca, M. P. (2021). Reduction in Acute Limb Ischemia with Rivaroxaban versus Placebo in Peripheral Artery Disease after Lower Extremity Revascularization: Insights from VOYAGER PAD. Circulation. -
Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques.
Gifani, M., Eddins, D. J., Kosuge, H., Zhang, Y., Paluri, S. L., Larson, T., … Smith, B. R. (2021). Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques. Advanced Functional Materials, 31(37). -
Macrophage LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Is Required for the Effect of CD47 Blockade on Efferocytosis and Atherogenesis.
Mueller, P. A., Kojima, Y., Huynh, K. T., Maldonado, R. A., Ye, J., Tavori, H., … Fazio, S. (2021). Macrophage LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Is Required for the Effect of CD47 Blockade on Efferocytosis and Atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA121316854. -
Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups.
Flores, A. M., Schuler, A., Eberhard, A. V., Olin, J. W., Cooke, J. P., Leeper, N. J., … Ross, E. G. (2021). Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups. Journal of the American Heart Association, e021976. -
Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells.
Wang, Y., Gao, H., Wang, F., Ye, Z., Mokry, M., Turner, A. W., … Leeper, N. J. (2021). Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells. Cardiovascular Research. -
Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone.
Berkowitz, S. D., Bauersachs, R. M., Szarek, M., Nehler, M. R., Debus, E. S., Patel, M. R., … Bonaca, M. P. (2022). Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone. Journal of Thrombosis and Haemostasis : JTH. -
Development of a polygenic risk score to improve detection of peripheral artery disease.
Wang, F., Ghanzouri, I., Leeper, N. J., Tsao, P. S., & Ross, E. G. (2022). Development of a polygenic risk score to improve detection of peripheral artery disease. Vascular Medicine (London, England), 1358863X211067564. -
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.
Rykaczewska, U., Zhao, Q., Saliba-Gustafsson, P., Lengquist, M., Kronqvist, M., Bergman, O., … Matic, L. (2022). Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA121317018. -
2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis.
Jarr, K.-U., Kojima, Y., Weissman, I. L., & Leeper, N. J. (2022). 2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis. Arteriosclerosis, Thrombosis, and Vascular Biology, 101161ATVBAHA122317049. -
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.
Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., … Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. Nature Genetics. -
Clustering cancers by shared transcriptional risk reveals novel targets for cancer therapy.
Gao, H., Baylis, R. A., Luo, L., Kojima, Y., Bell, C. F., Ross, E. G., … Leeper, N. J. (2022). Clustering cancers by shared transcriptional risk reveals novel targets for cancer therapy. Molecular Cancer, 21(1), 116. -
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis.
Jarr, K.-U., Ye, J., Kojima, Y., Ye, Z., Gao, H., Schmid, S., … Leeper, N. J. (2022). The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Nature Cardiovascular Research, 1(3), 253–262. -
An Alternate Explanation.
Alsaigh, T., Dhaliwal, G., Fukaya, E., Leeper, N. J., & Sayed, N. (2023). An Alternate Explanation. The New England Journal of Medicine, 388(14), 1318–1324. -
Spatial Metabolomics and the Vulnerable Atherosclerotic Plaque.
Luo, L., & Leeper, N. J. (2023). Spatial Metabolomics and the Vulnerable Atherosclerotic Plaque. Arteriosclerosis, Thrombosis, and Vascular Biology. -
Risk of Cancer After Diagnosis of Cardiovascular Disease.
Bell, C. F., Lei, X., Haas, A., Baylis, R. A., Gao, H., Luo, L., … Leeper, N. J. (2023). Risk of Cancer After Diagnosis of Cardiovascular Disease. JACC. CardioOncology, 5(4), 431–440. -
Identifying shared transcriptional risk patterns between atherosclerosis and cancer.
Baylis, R. A., Gao, H., Wang, F., Bell, C. F., Luo, L., Björkegren, J. L., & Leeper, N. J. (2023). Identifying shared transcriptional risk patterns between atherosclerosis and cancer. IScience, 26(9), 107513. -
Combined near infrared photoacoustic imaging and ultrasound detects vulnerable atherosclerotic plaque.
Schneider, M. K., Wang, J., Kare, A., Adkar, S. S., Salmi, D., Bell, C. F., … Ferrara, K. W. (2023). Combined near infrared photoacoustic imaging and ultrasound detects vulnerable atherosclerotic plaque. Biomaterials, 302, 122314. -
Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.
von Scheidt, M., Bauer, S., Ma, A., Hao, K., Kessler, T., Vilne, B., … Schunkert, H. (2023). Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques. MedRxiv : the Preprint Server for Health Sciences. -
Utilizing an induced pluripotent stem cell platform to model arterial calcification resulting from deficiency of CD73
Noishiki, C., Alsaigh, T., Wu, D., Adkar, S., Chandra, V., Klarin, D., … Sayed, N. (2023). Utilizing an induced pluripotent stem cell platform to model arterial calcification resulting from deficiency of CD73. VASCULAR MEDICINE. SAGE PUBLICATIONS LTD. -
Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.
Mokry, M., Boltjes, A., Slenders, L., Bel-Bordes, G., Cui, K., Brouwer, E., … Pasterkamp, G. (2022). Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. Nature Cardiovascular Research, 1(12), 1140–1155. -
Role of vascular smooth muscle cell clonality in atherosclerosis.
Luo, L., Fu, C., Bell, C. F., Wang, Y., & Leeper, N. J. (2023). Role of vascular smooth muscle cell clonality in atherosclerosis. Frontiers in Cardiovascular Medicine, 10, 1273596. -
Killing the two deadly birds of atherosclerosis and cancer with one stone
Bell, C. F., & Leeper, N. J. (2022). Killing the two deadly birds of atherosclerosis and cancer with one stone. NATURE CARDIOVASCULAR RESEARCH, 1(5), 403–404. -
Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.
Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., … Miller, C. L. (2023). Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci. Cell Genomics, 100465. -
Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC).
Tripathi, D., Manhas, A., Noishiki, C., Wu, D., Adkar, S., Sallam, K., … Sayed, N. (2023). Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC). Stem Cell Research, 75, 103285. -
Computational protocol to identify shared transcriptional risks and mutually beneficial compounds between diseases.
Gao, H., Zhang, M., Baylis, R. A., Wang, F., Björkegren, J. L., Kovacic, J. J., … Leeper, N. J. (2024). Computational protocol to identify shared transcriptional risks and mutually beneficial compounds between diseases. STAR Protocols, 5(1), 102883. -
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.
Mocci, G., Sukhavasi, K., Örd, T., Bankier, S., Singha, P., Arasu, U. T., … Björkegren, J. L. (2024). Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis. Circulation Research. -
Efferocytosis in atherosclerosis.
Adkar, S. S., & Leeper, N. J. (2024). Efferocytosis in atherosclerosis. Nature Reviews. Cardiology. -
Cancer Incidence After Diagnosis of Abdominal Aortic Aneurysm.
Luo, L., Haas, A. M., Bell, C. F., Baylis, R. A., Adkar, S. S., Fu, C., … Nead, K. T. (2024). Cancer Incidence After Diagnosis of Abdominal Aortic Aneurysm. Arteriosclerosis, Thrombosis, and Vascular Biology. -
Peripheral Artery Disease: Molecular Mechanisms and Novel Therapies.
Athavale, A., Fukaya, E., & Leeper, N. J. (2024). Peripheral Artery Disease: Molecular Mechanisms and Novel Therapies. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(6), 1165–1170. -
Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia.
Ballantyne, C. M., Vasas, S., Azizad, M., Clifton, P., Rosenson, R. S., Chang, T., … Gaudet, D. (2024). Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia. The New England Journal of Medicine. -
Postdoctoral T32 training is correlated with obtaining an academic primarily research faculty position.
Mueller, A. L., Schnirel, A., Kleppner, S., Tsao, P., & Leeper, N. J. (2024). Postdoctoral T32 training is correlated with obtaining an academic primarily research faculty position. PloS One, 19(6), e0303792. -
Multiplex Imaging for Cell Phenotyping of Early Human Atherosclerosis.
Elishaev, M., Li, B., Zhou, A., Salim, K., Leeper, N. J., Francis, G. A., … Wang, Y. (2024). Multiplex Imaging for Cell Phenotyping of Early Human Atherosclerosis. Journal of the American Heart Association, e034990. -
A Glimpse Into the Black Box: Using Machine Learning to Prioritize Predictors of Vascular Disease.
Leeper, N. J., & Adkar, S. S. (2023). A Glimpse Into the Black Box: Using Machine Learning to Prioritize Predictors of Vascular Disease. JACC. Advances, 2(7), 100563. -
Characterization of Peripheral Artery Disease and Associations with Traditional Risk Factors, Mobility, and Biomarkers in the Project Baseline Health Study.
Kercheval, J. B., Narcisse, D. I., Nguyen, M., Rao, S. V., Gutierrez, J. A., Leeper, N. J., … Swaminathan, R. V. (2024). Characterization of Peripheral Artery Disease and Associations with Traditional Risk Factors, Mobility, and Biomarkers in the Project Baseline Health Study. American Heart Journal. -
Killing the two deadly birds of atherosclerosis and cancer with one stone.
Bell, C. F., & Leeper, N. J. (2022). Killing the two deadly birds of atherosclerosis and cancer with one stone. Nature Cardiovascular Research, 1(5), 403–404. -
Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk.
Watts, G. F., Rosenson, R. S., Hegele, R. A., Goldberg, I. J., Gallo, A., Mertens, A., … Gaudet, D. (2024). Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk. The New England Journal of Medicine. -
Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis.
Bamezai, S., Zhang, Y., Kumari, M., Lotfi, M., Alsaigh, T., Luo, L., … Leeper, N. J. (2024). Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis. Nature Communications, 15(1), 8034. -
ZODASIRAN SILENCES HEPATIC ANGPTL3 LEADING TO DEEP AND DURABLE REDUCTIONS IN ATHEROGENIC LIPIDS AND LIPOPROTEINS IN MIXED DYSLIPIDEMIA PATIENTS: FINAL RESULTS FROM ARCHES-2, DOUBLE-BLIND PERIOD
Rosenson, R., Gaudet, D., Hegele, R., Ballantyne, C., Nicholls, S., Lucas, K., … Watts, G. (2024). ZODASIRAN SILENCES HEPATIC ANGPTL3 LEADING TO DEEP AND DURABLE REDUCTIONS IN ATHEROGENIC LIPIDS AND LIPOPROTEINS IN MIXED DYSLIPIDEMIA PATIENTS: FINAL RESULTS FROM ARCHES-2, DOUBLE-BLIND PERIOD. ATHEROSCLEROSIS. ELSEVIER IRELAND LTD. -
Temporal Effects of Plozasiran on Lipids and Lipoproteins in Persistent Chylomicronemia.
Watts, G. F., Hegele, R. A., Rosenson, R. S., Goldberg, I. J., Gallo, A., Mertens, A., … Leeper, N. J. (2024). Temporal Effects of Plozasiran on Lipids and Lipoproteins in Persistent Chylomicronemia. Circulation. -
Vascular smooth muscle cell plasticity in the tumor microenvironment.
Bell, C. F., Baylis, R. A., Lopez, N. G., Ma, W. F., Gao, H., Wang, F., … Leeper, N. J. (2024). Vascular smooth muscle cell plasticity in the tumor microenvironment. Cancer Communications (London, England). -
Cardiovascular Disease and Breast Cancer Stage at Diagnosis.
Angelov, I., Haas, A. M., Brock, E., Luo, L., Zhao, J., Smith, B. D., … Nead, K. T. (2025). Cardiovascular Disease and Breast Cancer Stage at Diagnosis. JAMA Network Open, 8(1), e2452890.
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Clinical problem-solving. One surprise after another.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Effect of Proton Pump Inhibitors on Endothelial Function
- Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities
- Patients With Intermittent Claudication Injected With ALDH Bright Cells
- PRESERVE-Zenith® Iliac Branch System Clinical Study
- Study Evaluating Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in Head and Neck Squamous Cell Carcinoma
Practice Locations
Vascular and Endovascular Care in Palo Alto Stanford, CA
Stanford, CAVascular and Endovascular Care in Palo Alto
300 Pasteur Drive, A32
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereHereditary Hemorrhagic Telangiectasia Center of Excellence Stanford, CA
Stanford, CAHereditary Hemorrhagic Telangiectasia Center of Excellence
300 Pasteur Dr
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereVascular Laboratory at Boswell Building Stanford, CA
Stanford, CAVascular Laboratory at Boswell Building
300 Pasteur Drive, A32
Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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