Joshua W. Knowles

Cardiologist

Center for Inherited Cardiovascular Disease

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-721-4363
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Preventive Cardiology

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Hypertrophic Cardiomyopathy Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Stanford South Asian Translational Heart Initiative

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Professional Education

Fellowship: Stanford University School of Medicine (2010) CA

Residency: Stanford University School of Medicine (2005) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2010)

Medical Education: University of North Carolina - Chapel Hill (2003) NC

PhD, University of North Carolina, Chapel Hill, Genetics and Molecular Biology (2001)

Board Certification: Internal Medicine, American Board of Internal Medicine (2006)

Honors & Awards

National Fellow to Faculty Transition Award, AHA (7/1/10-7/1/15)

Fellow, ACC (2012)

Fellow, AHA (2012)

Diplomate, National Lipid Association (2012)

Alderman Award for Excellence in Clinical Research, Stanford Cardiovascular Medicine (2008, 2009)

Fellowship Award, Future Leaders in CV Medicine (2006)

Dean's Fellowship, Stanford (2005)

Administrative Appointments

Chief Medical Officer, The FH Foundation, 2012

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Dimas, A. S., Lagou, V., Barker, A., Knowles, J. W., Mägi, R., & Prokopenko, I. (2014). Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes, 63(6), 2158-2171.

Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy.
Finocchiaro, G., Haddad, F., Pavlovic, A., Sinagra, G., Schnittger, I., & Ashley, E. (2014). Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy. Journal of cardiac failure, 20(4), 236-243.

Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry.
O'Brien, E. C., Roe, M. T., Fraulo, E. S., Peterson, E. D., Ballantyne, C. M., & Knowles, J. W. (2014). Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. American heart journal, 167(3), 342-349 e17.

Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement.
Finocchiaro, G., Murphy, D., Pavlovic, A., Haddad, F., Shiran, H., & Knowles, J. W. (2014). Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement. Echocardiography (Mount Kisco, N.Y.), 31(3), E80-4.

Prevalence and clinical correlates of right ventricular dysfunction in patients with hypertrophic cardiomyopathy.
Finocchiaro, G., Knowles, J. W., Pavlovic, A., Perez, M., Magavern, E., & Ashley, E. A. (2014). Prevalence and clinical correlates of right ventricular dysfunction in patients with hypertrophic cardiomyopathy. American journal of cardiology, 113(2), 361-367.

How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience.
Finocchiaro, G., Haddad, F., Pavlovic, A., Magavern, E., Sinagra, G., & Ashley, E. A. (2014). How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience. BMJ open, 4(6).

Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population
Kuo, J. Z., Sheu, W. H.-H., Assimes, T. L., Hung, Y.-J., Absher, D., & Chen, Y.-D. I. (2013). Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. DIABETOLOGIA, 56(12), 2619-2628.

Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System
Heidenreich, P. A., Lin, S., Knowles, J. W., Perez, M., Maddox, T. M., & Witteles, R. M. (2013). Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 6(6), 687-693.

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M.-F., & Frayling, T. M. (2013). Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes, 62(10), 3589-3598.

Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations
Coram, M. A., Duan, Q., Hoffmann, T. J., Thornton, T., Knowles, J. W., & Tang, H. (2013). Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations. AMERICAN JOURNAL OF HUMAN GENETICS, 92(6), 904-916.

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., & Walker, M. (2013). Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62(6), 2141-2150.

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang, P., Lan, F., Lee, A. S., Gong, T., Sanchez-Freire, V., & Wu, J. C. (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation, 127(16), 1677-1691.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
Den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. Jjm., Peal, D. S., & Loos, R. Jf. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature genetics, 45(6), 621-631.

Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp.
Knowles, J. W., Assimes, T. L., Tsao, P. S., Natali, A., Mari, A., & Abbasi, F. (2013). Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. Metabolism, 62(4), 548-553.

Role of international registries in enhancing the care of familial hypercholesterolaemia.
Hammond, E., Watts, G. F., Rubinstein, Y., Farid, W., Livingston, M., & Dawkins, H. J. (2013). Role of international registries in enhancing the care of familial hypercholesterolaemia. International journal of evidence-based healthcare, 11(2), 134-9.

Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Coram, M. A., Duan, Q., Hoffmann, T. J., Thornton, T., Knowles, J. W., & Tang, H. (2013). Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations. American journal of human genetics.

Large-scale association analysis identifies new risk loci for coronary artery disease
Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., & Samani, N. J. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. NATURE GENETICS, 45(1), 25-U52.

Exploring Predisposition and Treatment Response-the Promise of Genomics
Pan, S., & Knowles, J. W. (2012). Exploring Predisposition and Treatment Response-the Promise of Genomics. PROGRESS IN CARDIOVASCULAR DISEASES, 55(1), 56-63.

Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges
Knowles, J. W., Assimes, T. L., Kiernan, M., Pavlovic, A., Goldstein, B. A., & Ioannidis, J. Pa. (2012). Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 368-376.

The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease
deGoma, E. M., Knowles, J. W., Angeli, F., Budoff, M. J., & Rader, D. J. (2012). The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease. CARDIOLOGY IN REVIEW, 20(3), 118-129.

Use and overuse of left ventriculography
Witteles, R. M., Knowles, J. W., Perez, M., Morris, W. M., Spettell, C. M., & Heidenreich, P. A. (2012). Use and overuse of left ventriculography. AMERICAN HEART JOURNAL, 163(4), 617-?.

Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
Dewey, F. E., Chen, R., Cordero, S. P., Ormond, K. E., Caleshu, C., & Ashley, E. A. (2011). Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence. PLOS GENETICS, 7(9).

OVERUSE OF LEFT VENTRICULOGRAPHY
Witteles, R., Knowles, J. W., Perez, M., Morris, W. H., Spettell, C. M., & Heidenreich, P. A. (2011). OVERUSE OF LEFT VENTRICULOGRAPHY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E1289-E1289.

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Schunkert, H., Koenig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., & Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. NATURE GENETICS, 43(4), 333-U153.

A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium
Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., & Borecki, I. B. (2011). A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium. DIABETES, 60(4), 1329-1339.

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Assimes, T. L., Holm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., & Quertermous, T. (2010). Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(19), 1552-1563.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., & Loos, R. Jf. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53.

Hundreds of variants clustered in genomic loci and biological pathways affect human height
Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., & Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE, 467(7317), 832-838.

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Ingelsson, E., Langenberg, C., Hivert, M.-F., Prokopenko, I., Lyssenko, V., & Florez, J. C. (2010). Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. DIABETES, 59(5), 1266-1275.

Clinical assessment incorporating a personal genome
Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., & Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525-1535.

Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., & Sullivan, P. F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. NATURE GENETICS, 42(5), 441-U134.

Characterizing the admixed African ancestry of African Americans
Zakharia, F., Basu, A., Absher, D., Assimes, T. L., Go, A. S., & Tang, H. (2009). Characterizing the admixed African ancestry of African Americans. GENOME BIOLOGY, 10(12).

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
Assimes, T. L., Knowles, J. W., Basu, A., Iribarren, C., Southwick, A., & Quertermous, T. (2008). Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. HUMAN MOLECULAR GENETICS, 17(15), 2320-2328.

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Borchert, A., & Quertermous, T. (2008). A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. ATHEROSCLEROSIS, 198(1), 136-144.

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Volcik, K. A., & Quertermous, T. (2008). Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. HUMAN GENETICS, 123(4), 399-408.

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD
Knowles, J. W., Assimes, T. L., Boerwinkle, E., Fortmann, S. P., Go, A., & Quertermous, T. (2008). Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD. BMC MEDICAL GENETICS, 9.

Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics
Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25-36.

Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction
Knowles, J. W., Wang, H., Itakura, H., Southwick, A., Myers, R. M., & Hlatky, M. A. (2007). Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. AMERICAN HEART JOURNAL, 154(6), 1052-1058.

Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology
Knowles, J. W., Assimes, T. L., Li, J., Quertermous, T., & Cooke, J. P. (2007). Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(10), 2068-2078.

A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma
Knowles, J. W., Elliott, A. B., & Brody, J. (2007). A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma. ANNALS OF HEMATOLOGY, 86(9), 687-690.

Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A(-/-) apolipoprotein E-/- mice
Alexander, M. R., Knowles, J. W., Nishikimi, T., & Maeda, N. (2003). Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A(-/-) apolipoprotein E-/- mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 23(6), 1077-1082.

Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects
Knowles, J. W., Erickson, L. M., Guy, V. K., Sigel, C. S., Wilder, J. C., & Maeda, N. (2003). Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects. HUMAN GENETICS, 112(1), 62-70.

Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis
Ellmers, L. J., Knowles, J. W., Kim, H. S., Smithies, O., Maeda, N., & Cameron, V. A. (2002). Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 283(2), H707-H714.

Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
Hodgin, J. B., Knowles, J. W., Kim, H. S., Smithies, O., & Maeda, N. (2002). Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. JOURNAL OF CLINICAL INVESTIGATION, 109(4), 541-548.

Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide
Goy, M. F., Oliver, P. M., Purdy, K. E., Knowles, J. W., Fox, J. E., & Maeda, N. (2001). Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. BIOCHEMICAL JOURNAL, 358, 379-387.

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice
Knowles, J. W., Esposito, G., Mao, L., Hagaman, J. R., Fox, J. E., & Maeda, N. (2001). Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. JOURNAL OF CLINICAL INVESTIGATION, 107(8), 975-984.

Genetic modifiers of atherosclerosis in mice
Knowles, J. W., & Maeda, N. (2000). Genetic modifiers of atherosclerosis in mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(11), 2336-2345.

Enhanced atherosclerosis and kidney dysfunction in eNOS(-)/(-)Apo(-)/(-) mice are ameliorated by enalapril treatment
Knowles, J. W., Reddick, R. L., Jennette, J. C., Shesely, E. G., Smithies, O., & Maeda, N. (2000). Enhanced atherosclerosis and kidney dysfunction in eNOS(-)/(-)Apo(-)/(-) mice are ameliorated by enalapril treatment. JOURNAL OF CLINICAL INVESTIGATION, 105(4), 451-458.

Low salt intake down-regulates the guanylin signaling pathway in rat distal colon
Li, Z. P., Knowles, J. W., Goyeau, D., Prabhakar, S., Short, D. B., & Goy, M. F. (1996). Low salt intake down-regulates the guanylin signaling pathway in rat distal colon. GASTROENTEROLOGY, 111(6), 1714-1721.