Biography


I am a physician-scientist and the overall theme my research has been the genetic basis of cardiovascular disease across the continuum from Discovery to the development of Model Systems to the Translation of these findings to the clinic and most recently to the Public Health aspect of genetics. I completed his MD-PhD at UNC with Prof. Nobuyo Maeda and Nobel Laureate Oliver Smithies. I did Internal Medicine residency and Cardiology fellowship training at Stanford working with Dr. Tom Quertermous. Currently my Discovery and basic translational efforts center on understanding the genetic basis of insulin resistance using GWAS studies coupled with exploration in model systems including iPSCs and CRISPR screens. My clinical translational focus is on Familial Hypercholesterolemia (FH) and I am the volunteer Chief Medical Advisor of the FH Foundation (FHF) which is a patient-led organization dedicated to increasing awareness of FH, identifying and treating patients with FH and screening family members to prevent deleterious outcomes. I helped lead the FHF efforts to establish a national patient registry (CASCADE FH), apply for an ICD10 code for FH and am now using cutting-edge “big-data” approaches to identify previously undiagnosed FH patients in electronic medical records (FIND FH). I have published over 90 papers with research projects currently funded by the National Institutes of Health, the American Diabetes Association, the American Heart Association and the Doris Duke Charitable Foundation.

Professional Summary


Education & Certifications
  • Fellowship: Stanford University Cardiovascular Medicine Fellowship (2010) CA
  • Residency: Stanford University Internal Medicine Residency (2005) CA
  • Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2010)
  • Medical Education: University of North Carolina - Chapel Hill (2003) NC
  • PhD, University of North Carolina, Chapel Hill, Genetics and Molecular Biology (2001)

Honors & Awards
  • Alderman Award for Excellence in Clinical Research, Stanford Cardiovascular Medicine (2008, 2009)
  • Clinical Scholar, Doris Duke Charitable Foundation (6/1/16-6/1/19)
  • Dean's Fellowship, Stanford (2005)
  • Diplomate, National Lipid Association (2012)
  • Fellow, ACC (2012)
  • Fellow, AHA (2012)
  • Fellowship Award, Future Leaders in CV Medicine (2006)
  • National Fellow to Faculty Transition Award, AHA (7/1/10-7/1/15)
  • National Innovative Research Award, AHA

Memberships
  • Board Member, The FH Foundation (2012 - Present)

Administrative Appointments
  • Chief Research Advisor, The Family Heart Foundation (2012 - Present)
  • Co-Director, Translational Investigator Program (2017 - Present)
  • Co-Section Chief. Metabolism and Insulin Signaling, Stanford Diabetes Research Center` (2017 - Present)
  • Program Director, Cardiovascular Medicine Fellowship Program (2018 - Present)

Publications

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.


Practice Locations


Preventive Cardiology Stanford, CA
Stanford, CA

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 725-5909

Make An Appointment More Clinic Information » Getting Here »

Hypertrophic Cardiomyopathy Center Stanford, CA
Stanford, CA

300 Pasteur Drive , 2nd Floor, Room A260

Stanford , CA 94305

(650) 736-7878

Make An Appointment More Clinic Information » Getting Here »

Center for Inherited Cardiovascular Disease at Stanford Stanford, CA
Stanford, CA

300 Pasteur Drive, Heart Clinic 1, Clinic A21

Stanford , CA 94305

(650) 736-7878

Make An Appointment More Clinic Information » Getting Here »

Patient Ratings

(12 Ratings)

Overall Rating
5.0/5

View Ratings by Category

5.0/5
Friendliness
Friendliness/courtesy of the care provider
5.0/5
Explanations
Explanations the care provider gave you about your problem or condition
5.0/5
Listens
Concern the care provider showed for your questions or worries
5.0/5
Care provider's efforts to include you in decisions about your care
Care provider's efforts to include you in decisions about your treatment
5.0/5
Recommended to others
Likelihood of your recommending this care provider to others
0.0/5
Wait times
Wait time at clinic (from arriving to leaving)

How Our Ratings Work

The Patients Ratings and comments are gathered from our Patient Satisfaction Survey and displayed in their entirety.

Patient Satisfaction Survey Disclaimer

Patient Reviews

(66 reviews)

Confidant and attentive doctor.
Great very knowledgable doctor -- been guided by Dr. Knowles for a long time by now
Dr Knowles explained everything clearly in detail. Answered all questions completely and fully covered all concerns and direction of ongoing treatment.
He is a very knowledgeable doctor
He is an awesome Dr. and always attentive to my needs.
Very good Dr. He explained different things in words that I could understand. I appreciated that. Thank you.
Without a doubt the finest Doctor. He’s kind, knowledgeable, and respects the patients.
Dr. Knowles is one of the best doctors I have worked with in my life for four reasons: He is extremely knowledgeable. He answered every question I had authoritatively and went "above and beyond" to explain things He is very proactive. He goes way beyond the basics to tell me everything I can do to optimize my health He is on top of most all of the new trials, drugs, therapies people are looking at to help fight heart disease. I feel like he genuinely cares about me. I could sense his kindness. He even shared his cell phone, Dr. Knowles is an extraordinary doctor and Stanford should be very proud of this guy
He did a great job listening and communicating.
Great bedside manner, attentive, definitely new what my lab results were and how we would need to proceed further.
efficient, thoughtful
Dr. Knowles was familiar with my history and recent test results. He was attentive to any questions and comments from me. I am very pleased to have him as my cardiologist.
I would just like to thank him. He is extremely knowledgeable and provided some great insights and possible improvements to my existing therapy.
Great communicator and listener.
Excellent. very knowledgeable, very concise, very focused, very patient-centric.
Dr. Knowles is knowledgeable was generous with his time.
Thorough first visit with full discussion of action to take.
Joshua Knowles did a very good job explaining everything to me and took the time to make sure all of my questions were answered.
Dr Knowles took a lot of time to go over all of my concerns, explaining everything in detail, and we came up with a plan of action that I agree with.
Doctor Knowles, is a professional in all the activities that he performs during his work. He is a person with a true vocation to help patients. In my case, I am very grateful to him because he has followed my case since 2010, and although I have had other cardiologists, he has always kept informed about my health. And when he has found out that I need a referral to another doctor or to another department, he has always been there. He is a person who knows how to listen, and when he has to say something that sometimes I would not like to hear, he always tells me even if I do not like it, and in the end I end up thanking him for everything he says because I know it is for my health.
Very thorough and helpful. Easy to understand; did not use unfamiliar terms.
He is thoughtful, thorough, and an expert in his field.
Great doctor. Glad I have access. He gathers all the info and distills to the most important points.
Credible and professional
He is exceptional
Great manner and approach to people
Seemed very knowledgeable in his field
Outstanding, knowledgeable, thoughtful. Listened well and collaboratively worked out a plan for next steps.
Excellent expert clinician!
Thorough and thoughtful physician, who explained everything clearly.
Great doctor and I'm happy to have him take care of my heart health. Looking forward to meeting him in person on my next appointment.
Dr Joshua Knowles was extremely helpful with all the information he put forth and gave so much clarity regarding the reality of my condition. I am very grateful for the visit
Dr. Knowles was quite informative, educated me on my condition and I felt very supported and willing to work toward our common goal, my positive healthcare.
He is great! Good bedside manners. Answers all questions. Doesn’t rush.
Dr. Knowles was thorough, efficient, and kind during our visit.
Dr. Knowles is extremely knowledgeable, articulate, empathetic, and actually cares about his patients. That’s not always the case in other offices.
Dr. Knowles went out of his way (again) to help me. I really appreciate it.
Excellent doctor who took the time to really explain options and ideas. Will be recommending him to other friends and family.
Nice demeanor, knowledgeable. Good advise.
I enjoyed my visit with Dr. Knowles and his medical student Dr. Jenkins. I look forward to an in-person visit if the need arises.
he did a fantastic job educating me on my issues and discussing treatment options. really helpful
I look forward to my next visit. very happy to see Dr. Knowles. I am grateful for his input.
Great to speak with!
I felt that he was extremely knowledgeable and I trust his evaluations.
Extremely knowledgeable, clear, and helpful.
I really appreciate the time Dr. Knowles took to explain everything to me in clear detail. I found him to be very kind and informative. I'm grateful for his consultation. Thank you!
Dr. Knowles is the best.
The doctors spent a lot of time with me, explanations good, I was very happy about the visit & doctors.
Dr. Schroeder recommended Dr. Knowles. I was sorry the follow up had to be postponed.
Exceeded expectations, very thorough, knowledgeable (I am a physician).
Told friends "Stanford is the best!
Very good.
Dr. Knowles spent quite a lot of time on my history and in explaining what I needed to do to improve and extend health, and motivating me to be more proactive in doing it.
Everyone was very caring & nice.
Doctor was great and took the time to go over details with me.
Very thoughtful and informed discussion of treatment options.
Good experience.
Dr. Knowles and Ms. Lamendola both are consummate professionals.
Dr. Knowles was outstanding!
Dr. Knowles is friendly, thorough, kind, professional, and shares his expertise in a clear and genuine manner.
Great doctor.
I cannot tell you how thankful I am that I am able to have such good drs. & PA's. Its a comfort.
I felt like I didn't fit his "study" protocol so he wasn't interested in me anymore.
He was very informative.
My doc didn't give info on my meds b/c he didn't prescribe them.
He was amazing!

View More »

Referring Physicians

LOG INTO MEDLINK