Matthew Wheeler

Cardiologist

Instructor, Medicine - Cardiovascular Medicine
Bio:   I am a physician scientist with interests in myocardial disease, therapeutics and genomics. My background includes research training in both myocardial and skeletal muscle biology and genetics, cardiovascular phenotyping in mouse models and cell culture; single-cell phenotyping of cardiomyocytes and more recently iPS cell derived cardiomyocytes; and extensive development work in allele-specific silencing. I analyzed whole genome sequencing for clinically actionable rare and novel variants, first from a single patient and now from groups of inherited cardiomyopathy patients. In addition to my research training, I am a physician with interest and experience treating patients with hypertrophic cardiomyopathy and other inherited cardiomyopathies. I have clinical training in medicine, cardiology, cardiovascular genetics, and advanced heart failure. I have extensive translational science experience, participating in several ongoing clinical trials for hypertrophic cardiomyopathy, ATTR cardiac amyloidosis, and mechanical circulatory support. I am the executive director and adult medical director of Stanford’s new NIH-funded Center for Undiagnosed Diseases and have been an active participant in the start-up of the Undiagnosed Diseases Network. I co-developed a randomized, controlled trial of exercise in hypertrophic cardiomyopathy patients, the results of which are anticipated in 2016. As a junior investigator transitioning to independence, I continue pursuing projects and collaborations at the intersection of cardiovascular genetics, genomics, and clinical investigation.

Heart Transplant Program

  • 300 Pasteur Drive
  • 2nd Floor, Room A260
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Center for Inherited Cardiovascular Disease

  • 300 Pasteur Drive
  • 2nd Floor, Room H2157
  • Stanford, CA 94305
  • Phone: 650-721-4363
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Hypertrophic Cardiomyopathy Center

  • 300 Pasteur Drive
  • 2nd Floor, Room A260
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Amyloid Center

  • 300 Pasteur Drive
  • 2nd Floor, Room A260
  • Stanford, CA 94305
  • Phone: 650-725-6186
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Stanford Sports Cardiology

  • 300 Pasteur Drive
  • 2nd Floor, Room A260
  • Stanford, CA 94305
  • Phone: 650-736-7878
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Professional Education

  • Board Certification: Advanced Heart Failure and Transplant Cardiology, American Board of Internal Medicine (2014)
  • Residency: Stanford University Hospital -Clinical Excellence Research Center (2007) CA
  • Fellowship: Stanford University School of Medicine (2013) CA
  • Fellowship: Stanford University School of Medicine (2012) CA
  • Medical Education: University of Chicago Pritzker School of Medicine (2005) IL
  • Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2012)
  • Board Certification: Internal Medicine, American Board of Internal Medicine (2008)
  • Bachelor of Arts, Williams College, History and Biology (1998)

Administrative Appointments

  • Adult Medical Director, Center for Undiagnosed Diseases at Stanford (2015 - Present)
  • Executive Director, Center for Undiagnosed Diseases at Stanford (2014 - Present)

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.