Heart transplantation is a well-established therapeutic option for many patients with end-stage heart disease. A major challenge in heart transplantation today is providing effective immunosuppression to prevent graft rejection while minimizing the many adverse effects of currently available therapies.To systematically review current immunosuppressive treatment strategies after heart transplantation and to review emerging drugs in various stages of development.A comprehensive literature review was performed using the online PubMed and Pharmaprojects databases.This article gives an overview of the immunosuppressive agents in current use, with a detailed review of emerging drugs with novel therapeutic targets.
View details for DOI 10.1517/14728210902791605
View details for Web of Science ID 000264685900001
View details for PubMedID 19265486