Professional Summary
Education & Certifications
- Fellowship: University of Michigan Hematology Oncology Fellowship (1977) MI
- Residency: University of Washington Medical Center Dept of Medicine (1973) WA
- Medical Education: Harvard Medical School (1969) MA
- Board Certification: American Board of Internal Medicine, Hematology (1978)
- Fellowship: University Hospital Zurich (1973) Switzerland
- Board Certification: American Board of Internal Medicine, Internal Medicine (1973)
- Internship: Harborview Medical Center (1970) WA
- M.D., Harvard Medical School, Medicine (1969)
Honors & Awards
- Fellow, American Association for the Advancement of Science (2015)
- Member, American Society for Clinical Investigation (to present)
- Member, Association of American Professors (1991)
- Mentorship Award, American Society of Hematology (2012)
- National Academy of Sciences, Institute of Medicine (Inducted 2001)
- President, American Society of Hematology (2001)
- Walter Hewlitt Physician Scientist Award, Stanford Department of Medicine (2012)
Administrative Appointments
- Deputy Director, Stanford Cancer Center (2005 - 2008)
- Director, Stanford Cancer Institute (2008 - 2018)
Publications
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Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination
Gangi-Peterson, L., Sorscher, D. H., Reynolds, J. W., Kepler, T. B., & Mitchell, B. S. (1999). Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination. JOURNAL OF CLINICAL INVESTIGATION, 103(6), 833–841. -
ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5 '-nucleotidase - Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity
Spychala, J., Chen, V., Oka, J., & Mitchell, B. S. (1999). ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5 '-nucleotidase - Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity. EUROPEAN JOURNAL OF BIOCHEMISTRY, 259(3), 851–858. -
Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region
Spychala, J., Zimmermann, A. G., & Mitchell, B. S. (1999). Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(32), 22705–22712. -
Association of terminal deoxynucleotidyl transferase with Ku
Mahajan, K. N., Gangi-Peterson, L., Sorscher, D. H., Wang, J. S., Gathy, K. N., Mahajan, N. P., … Mitchell, B. S. (1999). Association of terminal deoxynucleotidyl transferase with Ku. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 13926–13931. -
Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
Gu, J. J., Stegmann, S., Gathy, K., Murray, R., Laliberte, J., Ayscue, L., & Mitchell, B. S. (2000). Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. JOURNAL OF CLINICAL INVESTIGATION, 106(4), 599–606. -
Human cytosolic 5 '-nucleotidase I - Characterization and role in nucleoside analog resistance
Hunsucker, S. A., Spychala, J., & Mitchell, B. S. (2001). Human cytosolic 5 '-nucleotidase I - Characterization and role in nucleoside analog resistance. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 10498–10504. -
PURINOGENIC IMMUNODEFICIENCY DISEASES - DIFFERENTIAL EFFECTS OF DEOXYADENOSINE AND DEOXYGUANOSINE ON DNA-SYNTHESIS IN HUMAN T-LYMPHOBLASTS
Wilson, J. M., Mitchell, B. S., Daddona, P. E., & Kelley, W. N. (1979). PURINOGENIC IMMUNODEFICIENCY DISEASES - DIFFERENTIAL EFFECTS OF DEOXYADENOSINE AND DEOXYGUANOSINE ON DNA-SYNTHESIS IN HUMAN T-LYMPHOBLASTS. JOURNAL OF CLINICAL INVESTIGATION, 64(5), 1475–1484. -
Tumor uptake and elimination of 2 ',2 '-difluoro-2 '-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: Correlation with in vivo tumor response
Blackstock, A. W., Lightfoot, H., Case, L. D., Tepper, J. E., Mukherji, S. K., Mitchell, B. S., … Hess, S. M. (2001). Tumor uptake and elimination of 2 ',2 '-difluoro-2 '-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: Correlation with in vivo tumor response. CLINICAL CANCER RESEARCH, 7(10), 3263–3268. -
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
Rodriguez, C. O., Mitchell, B. S., Ayres, M., Eriksson, S., & Gandhi, V. (2002). Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. CANCER RESEARCH, 62(11), 3100–3105. -
Inhibition of nucleoside transport by p38 MAPK inhibitors
Huang, M., Wang, Y. H., Collins, M., Gu, J. J., Mitchell, B. S., & Graves, L. M. (2002). Inhibition of nucleoside transport by p38 MAPK inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(32), 28364–28367. -
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair
Mahajan, K. N., McElhinny, S. A. N., Mitchell, B. S., & Ramsden, D. A. (2002). Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair. MOLECULAR AND CELLULAR BIOLOGY, 22(14), 5194–5202. -
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools
Huang, M., Wang, Y. H., Collins, M., Mitchell, B. S., & Graves, L. M. (2002). A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. MOLECULAR PHARMACOLOGY, 62(3), 463–472. -
Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
Rai, K. R., Freter, C. E., Mercier, R. J., Cooper, M. R., Mitchell, B. S., Stadtmauer, E. A., … Brettman, L. (2002). Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. JOURNAL OF CLINICAL ONCOLOGY, 20(18), 3891–3897. -
Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes
Spychala, J., & Mitchell, B. S. (2002). Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 140(2), 84–91. -
Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia
van Deventer, H. W., Hall, M. D., Orlowski, R. Z., Mitchell, B. S., Berkowitz, L. R., Hogan, C., … Shea, T. C. (2002). Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia. AMERICAN JOURNAL OF HEMATOLOGY, 71(3), 184–190. -
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
Orlowski, R. Z., Stinchcombe, T. E., Mitchell, B. S., Shea, T. C., Baldwin, A. S., Stahl, S., … Soignet, S. L. (2002). Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 20(22), 4420–4427. -
Inhibition of nucleoside transport by protein kinase inhibitors
Huang, M., Wang, Y. H., Cogut, S. B., Mitchell, B. S., & Graves, L. M. (2003). Inhibition of nucleoside transport by protein kinase inhibitors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 304(2), 753–760. -
Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion
Gu, J. J., Gathy, K., Santiago, L., Chen, E., Huang, M., Graves, L. M., & Mitchell, B. S. (2003). Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. BLOOD, 101(12), 4958–4965. -
The proteasome - An emerging therapeutic target in cancer
Mitchell, B. S. (2003). The proteasome - An emerging therapeutic target in cancer. NEW ENGLAND JOURNAL OF MEDICINE, 348(26), 2597–2598. -
Targeted disruption of the inosine 5 '-monophosphate dehydrogenase type I gene in mice
Gu, J. J., Tolin, A. K., Jain, J., Huang, H., Santiago, L., & Mitchell, B. S. (2003). Targeted disruption of the inosine 5 '-monophosphate dehydrogenase type I gene in mice. MOLECULAR AND CELLULAR BIOLOGY, 23(18), 6702–6712. -
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase
Mahajan, K. N., & Mitchell, B. S. (2003). Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(19), 10746–10751. -
SEX CHROMATIN DETERMINATIONS IN SELECTED CASES OF DEVELOPMENTAL SEX ABNORMALITIES WITH AN ASSESSMENT OF RESULTS
BAMFORD, S. B., CASSIN, C. M., & Mitchell, B. S. (1963). SEX CHROMATIN DETERMINATIONS IN SELECTED CASES OF DEVELOPMENTAL SEX ABNORMALITIES WITH AN ASSESSMENT OF RESULTS. ACTA CYTOLOGICA, 7(3), 151-? -
Role of estrogen receptor in the regulation of ecto-5 '-nucleotidase and adenosine in breast cancer
Spychala, J., Lazarowski, E., Ostapkowicz, A., Ayscue, L. H., Jin, A., & Mitchell, B. S. (2004). Role of estrogen receptor in the regulation of ecto-5 '-nucleotidase and adenosine in breast cancer. CLINICAL CANCER RESEARCH, 10(2), 708–717. -
On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa
Aherne, A., Kennan, A., Kenna, P. F., McNally, N., Lloyd, D. G., Alberts, I. L., … Humphries, P. (2004). On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. HUMAN MOLECULAR GENETICS, 13(6), 641–650. -
Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia - Part I. In vivo studies
Malek, K., Boosalis, M. S., Waraska, K., Mitchell, B. S., & Wright, D. G. (2004). Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia - Part I. In vivo studies. LEUKEMIA RESEARCH, 28(11), 1125–1136. -
Regulation of equilibrative nucleoside uptake by protein kinase inhibitors
Huang, M., Wang, Y. H., Mitchell, B. S., & Graves, L. M. (2004). Regulation of equilibrative nucleoside uptake by protein kinase inhibitors. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 23(8-9), 1445–1450. -
Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl
Gu, J. J., Santiago, L., & Mitchell, B. S. (2005). Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl. BLOOD, 105(8), 3270–3277. -
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
Orlowski, R. Z., Voorhees, P. M., Garcia, R. A., Hall, M. D., Kudrik, F. J., Allred, T., … Dees, E. C. (2005). Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. BLOOD, 105(8), 3058–3065. -
RESISTANCE TO 1-BETA-D-ARABINOFURANOSYLCYTOSINE IN HUMAN T-LYMPHOBLASTS MEDIATED BY MUTATIONS WITHIN THE DEOXYCYTIDINE KINASE GENE
Owens, J. K., Shewach, D. S., Ullman, B., & Mitchell, B. S. (1992). RESISTANCE TO 1-BETA-D-ARABINOFURANOSYLCYTOSINE IN HUMAN T-LYMPHOBLASTS MEDIATED BY MUTATIONS WITHIN THE DEOXYCYTIDINE KINASE GENE. CANCER RESEARCH, 52(9), 2389–2393. -
COMPARISON OF THE EFFECTS OF MIZORIBINE WITH THOSE OF AZATHIOPRINE, 6-MERCAPTOPURINE, AND MYCOPHENOLIC-ACID ON LYMPHOCYTE-T PROLIFERATION AND PURINE RIBONUCLEOTIDE METABOLISM
DAYTON, J. S., Turka, L. A., Thompson, C. B., & Mitchell, B. S. (1992). COMPARISON OF THE EFFECTS OF MIZORIBINE WITH THOSE OF AZATHIOPRINE, 6-MERCAPTOPURINE, AND MYCOPHENOLIC-ACID ON LYMPHOCYTE-T PROLIFERATION AND PURINE RIBONUCLEOTIDE METABOLISM. MOLECULAR PHARMACOLOGY, 41(4), 671–676. -
ACCO: ASCO core curriculum outline
Muss, H. B., Von Roenn, J., Damon, L. E., DeAngelis, L. M., Flaherty, L. E., Harari, P. M., … Sparano, J. (2005). ACCO: ASCO core curriculum outline. JOURNAL OF CLINICAL ONCOLOGY, 23(9), 2049–2077. -
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies
Kurtzberg, J., Ernst, T. J., Keating, M. J., Gandhi, V., Hodge, J. P., Kisor, D. F., … Mitchell, B. S. (2005). Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 23(15), 3396–3403. -
The 5 '-nucleotidases as regulators of nucleotide and drug metabolism
Hunsucker, S. A., Mitchell, B. S., & Spychala, J. (2005). The 5 '-nucleotidases as regulators of nucleotide and drug metabolism. PHARMACOLOGY & THERAPEUTICS, 107(1), 1–30. -
Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic acid by GTP
Ji, Y. S., Gu, J. J., Makhov, A. M., Griffith, J. D., & Mitchell, B. S. (2006). Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic acid by GTP. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(1), 206–212. -
Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia
Douvas, M. G., Hogan, K. N., Ji, Y. S., Hollenback, D., Bonham, L., Singer, J. W., & Mitchell, B. S. (2006). Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. LEUKEMIA RESEARCH, 30(8), 1027–1036. -
CD11C (LEU-M5) EXPRESSION CHARACTERIZES A B-CELL CHRONIC LYMPHOPROLIFERATIVE DISORDER WITH FEATURES OF BOTH CHRONIC LYMPHOCYTIC-LEUKEMIA AND HAIRY-CELL LEUKEMIA
Hanson, C. A., Gribbin, T. E., SCHNITZER, B., SCHLEGELMILCH, J. A., Mitchell, B. S., & Stoolman, L. M. (1990). CD11C (LEU-M5) EXPRESSION CHARACTERIZES A B-CELL CHRONIC LYMPHOPROLIFERATIVE DISORDER WITH FEATURES OF BOTH CHRONIC LYMPHOCYTIC-LEUKEMIA AND HAIRY-CELL LEUKEMIA. BLOOD, 76(11), 2360–2367. -
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
DeAngelo, D. J., Yu, D., Johnson, J. L., Coutre, S. E., Stone, R. M., Stopeck, A. T., … Larson, R. A. (2007). Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. BLOOD, 109(12), 5136–42. -
Guanine nucleotide depletion inhibits pre-ribosornal RNA synthesis and causes nucleolar disruption
Huang, M., Ji, Y. S., Itahana, K., Zhang, Y., & Mitchell, B. (2008). Guanine nucleotide depletion inhibits pre-ribosornal RNA synthesis and causes nucleolar disruption. LEUKEMIA RESEARCH, 32(1), 131–41. -
Guanine ribonucleotide depletion inhibits T cell activation.
DAYTON, J. S., Turka, L. A., Thompson, C. B., & Mitchell, B. S. (1991). Guanine ribonucleotide depletion inhibits T cell activation. Advances in Experimental Medicine and Biology, 309B, 293–296. -
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H
Huang, M., Wang, Y., Gu, J., Yang, J., Noel, K., Mitchell, B. S., … Graves, L. M. (2008). Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. LEUKEMIA RESEARCH, 32(8), 1268–78. -
Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9)
Huang, M., & Mitchell, B. S. (2008). Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9). NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. CHICAGO,IL,IL,IL,IL,IL,IL,IL,IL,IL,IL,IL,IL,IL: TAYLOR & FRANCIS INC. -
Depletion of Guanine Nucleotides Leads to the Mdm2-Dependent Proteasomal Degradation of Nucleostemin
Huang, M., Itahana, K., Zhang, Y., & Mitchell, B. S. (2009). Depletion of Guanine Nucleotides Leads to the Mdm2-Dependent Proteasomal Degradation of Nucleostemin. CANCER RESEARCH, 69(7), 3004–12. -
CLONING AND EXPRESSION OF HUMAN DEOXYCYTIDINE KINASE CDNA
CHOTTINER, E. G., Shewach, D. S., Datta, N. S., Ashcraft, E., GRIBBIN, D., Ginsburg, D., … Mitchell, B. S. (1991). CLONING AND EXPRESSION OF HUMAN DEOXYCYTIDINE KINASE CDNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(4), 1531–1535. -
GUANINE RIBONUCLEOTIDE DEPLETION INHIBITS T-CELL ACTIVATION - MECHANISM OF ACTION OF THE IMMUNOSUPPRESSIVE DRUG MIZORIBINE
Turka, L. A., Dayton, J., Sinclair, G., Thompson, C. B., & Mitchell, B. S. (1991). GUANINE RIBONUCLEOTIDE DEPLETION INHIBITS T-CELL ACTIVATION - MECHANISM OF ACTION OF THE IMMUNOSUPPRESSIVE DRUG MIZORIBINE. JOURNAL OF CLINICAL INVESTIGATION, 87(3), 940–948. -
Synthesis of 2 '-Deoxy-2 '-[F-18]Fluoro-9-beta-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET
Namavari, M., Chang, Y.-F., Kusler, B., Yaghoubi, S., Mitchell, B. S., & Gambhir, S. S. (2011). Synthesis of 2 '-Deoxy-2 '-[F-18]Fluoro-9-beta-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET. MOLECULAR IMAGING AND BIOLOGY, 13(5), 812–18. -
Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation
Huang, M., Whang, P., Chodaparambil, J. V., Pollyea, D. A., Kusler, B., Xu, L., … Mitchell, B. S. (2011). Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(13), 11035–46. -
Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53
Huang, M., Whang, P., Lewicki, P., & Mitchell, B. S. (2011). Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53. MOLECULAR PHARMACOLOGY, 80(1), 40–48. -
Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
Pollyea, D. A., Raval, A., Kusler, B., Gotlib, J. R., Alizadeh, A. A., & Mitchell, B. S. (2011). Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. HEMATOLOGICAL ONCOLOGY, 29(3), 157–60. -
Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells
Raval, A., Kusler, B., Pang, W. W., Weissman, I. L., Mitchell, B. S., & Park, C. Y. (2012). Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells. LEUKEMIA, 26(4), 853–855. -
Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia
Pollyea, D. A., Kohrt, H. E., Gallegos, L., Figueroa, M. E., Abdel-Wahab, O., Zhang, B., … Medeiros, B. C. (2012). Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. LEUKEMIA, 26(5), 893–901. -
BIOCHEMICAL BASIS FOR DIFFERENTIAL DEOXYADENOSINE TOXICITY TO LYMPHOBLAST-T AND LYMPHOBLAST-B - ROLE FOR 5'-NUCLEOTIDASE
Wortmann, R. L., Mitchell, B. S., Edwards, N. L., & Fox, I. H. (1979). BIOCHEMICAL BASIS FOR DIFFERENTIAL DEOXYADENOSINE TOXICITY TO LYMPHOBLAST-T AND LYMPHOBLAST-B - ROLE FOR 5'-NUCLEOTIDASE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 76(5), 2434–2437. -
Understanding disparities in leukemia: a national study
Patel, M. I., Ma, Y., Mitchell, B. S., & Rhoads, K. F. (2012). Understanding disparities in leukemia: a national study. CANCER CAUSES & CONTROL, 23(11), 1831–37. -
Reduced rRNA expression and increased rDNA promoter methylation in CD34(+) cells of patients with myelodysplastic syndromes
Raval, A., Sridhar, K. J., Patel, S., Turnbull, B. B., Greenberg, P. L., & Mitchell, B. S. (2012). Reduced rRNA expression and increased rDNA promoter methylation in CD34(+) cells of patients with myelodysplastic syndromes. BLOOD, 120(24), 4812–18. -
Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia.
Pollyea, D. A., Zehnder, J., Coutre, S., Gotlib, J. R., Gallegos, L., Abdel-Wahab, O., … Medeiros, B. C. (2013). Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica, 98(4), 591–96. -
Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts.
Wortmann, R. L., Mitchell, B. S., Edwards, N. L., & Fox, I. H. (1979). Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts. Advances in Experimental Medicine and Biology, 122B, 243–259. -
Age and Genetics How Do Prognostic Factors at Diagnosis Explain Disparities in Acute Myeloid Leukemia?
Patel, M. I., Ma, Y., Mitchell, B. S., & Rhoads, K. F. (2015). Age and Genetics How Do Prognostic Factors at Diagnosis Explain Disparities in Acute Myeloid Leukemia? AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 38(2), 159–64. -
MUTATIONS INDUCED AT THE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS OF HUMAN T-LYMPHOBLASTS BY PERTURBATIONS OF PURINE DEOXYRIBONUCLEOSIDE TRIPHOSPHATE POOLS
Mattano, S. S., PALELLA, T. D., & Mitchell, B. S. (1990). MUTATIONS INDUCED AT THE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS OF HUMAN T-LYMPHOBLASTS BY PERTURBATIONS OF PURINE DEOXYRIBONUCLEOSIDE TRIPHOSPHATE POOLS. CANCER RESEARCH, 50(15), 4566–4571. -
EFFECTS OF GUANINE RIBONUCLEOTIDE ACCUMULATION ON THE METABOLISM AND CELL-CYCLE OF HUMAN LYMPHOID-CELLS
Sidi, Y., Hudson, J. L., & Mitchell, B. S. (1985). EFFECTS OF GUANINE RIBONUCLEOTIDE ACCUMULATION ON THE METABOLISM AND CELL-CYCLE OF HUMAN LYMPHOID-CELLS. CANCER RESEARCH, 45(10), 4940–4945. -
TRANSCRIPTIONAL REGULATION OF THE C-MYC PROTOONCOGENE BY 1,25-DIHYDROXYVITAMIN-D3 IN HL-60 PROMYELOCYTIC LEUKEMIA-CELLS
Simpson, R. U., Hsu, T., Begley, D. A., Mitchell, B. S., & ALIZADEH, B. N. (1987). TRANSCRIPTIONAL REGULATION OF THE C-MYC PROTOONCOGENE BY 1,25-DIHYDROXYVITAMIN-D3 IN HL-60 PROMYELOCYTIC LEUKEMIA-CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY, 262(9), 4104–4108. -
HUMAN T-LYMPHOBLAST DEOXYCYTIDINE KINASE - PURIFICATION AND PROPERTIES
Datta, N. S., Shewach, D. S., Hurley, M. C., Mitchell, B. S., & Fox, I. H. (1989). HUMAN T-LYMPHOBLAST DEOXYCYTIDINE KINASE - PURIFICATION AND PROPERTIES. BIOCHEMISTRY, 28(1), 114–123. -
KINETIC-PROPERTIES AND INHIBITION OF HUMAN LYMPHOBLAST-T DEOXYCYTIDINE KINASE
Datta, N. S., Shewach, D. S., Mitchell, B. S., & Fox, I. H. (1989). KINETIC-PROPERTIES AND INHIBITION OF HUMAN LYMPHOBLAST-T DEOXYCYTIDINE KINASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(16), 9359–9364. -
ASSOCIATION OF A MATURE B-CELL LEUKEMIA WITH A 4P+ CHROMOSOMAL ABNORMALITY - DERIVATION AND CHARACTERIZATION OF A CELL-LINE
Gribbin, T. E., Stein, C. K., Harrison, J. S., Glover, T. W., Hanson, C. A., Wasmuth, J. J., … Mitchell, B. S. (1989). ASSOCIATION OF A MATURE B-CELL LEUKEMIA WITH A 4P+ CHROMOSOMAL ABNORMALITY - DERIVATION AND CHARACTERIZATION OF A CELL-LINE. LEUKEMIA, 3(9), 643–647. -
Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase.
Datta, N. S., Shewach, D. S., Hurley, M. C., Mitchell, B. S., & Fox, I. H. (1989). Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase. Advances in Experimental Medicine and Biology, 253B, 87–92. -
Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies.
CHOTTINER, E. G., Gribbin, T. E., Ginsburg, D., & Mitchell, B. S. (1989). Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies. Progress in Clinical and Biological Research, 319, 55–64. -
Autosomal dominant hemolytic anemia and adenosine deaminase overproduction.
CHOTTINER, E. G., Ginsburg, D., & Mitchell, B. S. (1989). Autosomal dominant hemolytic anemia and adenosine deaminase overproduction. Advances in Experimental Medicine and Biology, 253A, 493–497. -
ERYTHROCYTE ADENOSINE-DEAMINASE OVERPRODUCTION IN HEREDITARY HEMOLYTIC-ANEMIA
CHOTTINER, E. G., Ginsburg, D., TARTAGLIA, A. P., & Mitchell, B. S. (1989). ERYTHROCYTE ADENOSINE-DEAMINASE OVERPRODUCTION IN HEREDITARY HEMOLYTIC-ANEMIA. BLOOD, 74(1), 448–453. -
DIFFERENTIAL METABOLISM OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LEUKEMIC CELLS
Shewach, D. S., & Mitchell, B. S. (1989). DIFFERENTIAL METABOLISM OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LEUKEMIC CELLS. CANCER RESEARCH, 49(23), 6498–6502. -
DIFFERENTIAL METABOLISM OF DEOXYRIBONUCLEOSIDES BY LEUKEMIC T-CELLS OF IMMATURE AND MATURE PHENOTYPE
Sidi, Y., Edwards, N. L., Winkler, C., Bunn, P., & Mitchell, B. S. (1985). DIFFERENTIAL METABOLISM OF DEOXYRIBONUCLEOSIDES BY LEUKEMIC T-CELLS OF IMMATURE AND MATURE PHENOTYPE. BRITISH JOURNAL OF HAEMATOLOGY, 61(1), 125–134. -
ELEVATED ADENOSINE-DEAMINASE ACTIVITY AND HEREDITARY HEMOLYTIC-ANEMIA - EVIDENCE FOR ABNORMAL TRANSLATIONAL CONTROL OF PROTEIN-SYNTHESIS
CHOTTINER, E. G., Cloft, H. J., TARTAGLIA, A. P., & Mitchell, B. S. (1987). ELEVATED ADENOSINE-DEAMINASE ACTIVITY AND HEREDITARY HEMOLYTIC-ANEMIA - EVIDENCE FOR ABNORMAL TRANSLATIONAL CONTROL OF PROTEIN-SYNTHESIS. JOURNAL OF CLINICAL INVESTIGATION, 79(3), 1001–1005. -
Characterization of arabinosylguanine resistance in a lymphoblastoid cell line.
Shewach, D. S., & Mitchell, B. S. (1986). Characterization of arabinosylguanine resistance in a lymphoblastoid cell line. Advances in Experimental Medicine and Biology, 195, 605–609. -
PURINOGENIC IMMUNODEFICIENCY DISEASES - SELECTIVE TOXICITY OF DEOXYRIBONUCLEOSIDES FOR T-CELLS
Mitchell, B. S., MEJIAS, E., Daddona, P. E., & Kelley, W. N. (1978). PURINOGENIC IMMUNODEFICIENCY DISEASES - SELECTIVE TOXICITY OF DEOXYRIBONUCLEOSIDES FOR T-CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(10), 5011–5014. -
TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN - CLINICAL AND BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION
Koller, C. A., Mitchell, B. S., Grever, M. R., MEJIAS, E., Malspeis, L., & METZ, E. N. (1979). TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN - CLINICAL AND BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION. CANCER TREATMENT REPORTS, 63(11-1), 1949–1952. -
Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts.
Wilson, J. M., Mitchell, B. S., & Kelley, W. N. (1979). Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Advances in Experimental Medicine and Biology, 122B, 265–270. -
Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin.
Mitchell, B. S., Koller, C. A., & Kelley, W. N. (1979). Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin. Advances in Experimental Medicine and Biology, 122B, 347–350. -
GENETIC EXPRESSION OF ADENOSINE-DEAMINASE IN HUMAN LYMPHOID MALIGNANCIES
Gan, T. E., DADONNA, P. E., & Mitchell, B. S. (1987). GENETIC EXPRESSION OF ADENOSINE-DEAMINASE IN HUMAN LYMPHOID MALIGNANCIES. BLOOD, 69(5), 1376–1380. -
DIFFERENTIAL METABOLISM OF GUANINE NUCLEOSIDES BY HUMAN LYMPHOID-CELL LINES
Mitchell, B. S., & Sidi, Y. (1985). DIFFERENTIAL METABOLISM OF GUANINE NUCLEOSIDES BY HUMAN LYMPHOID-CELL LINES. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 179(4), 427–431. -
BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION INVIVO - DIFFERENTIAL-EFFECTS IN ACUTE AND CHRONIC T-CELL LEUKEMIA
Mitchell, B. S., Sidi, Y., Hershfield, M., & Koller, C. A. (1985). BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION INVIVO - DIFFERENTIAL-EFFECTS IN ACUTE AND CHRONIC T-CELL LEUKEMIA. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 451(OCT), 129–137. -
METABOLISM AND SELECTIVE CYTO-TOXICITY OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LYMPHOBLASTS
Shewach, D. S., Daddona, P. E., Ashcraft, E., & Mitchell, B. S. (1985). METABOLISM AND SELECTIVE CYTO-TOXICITY OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LYMPHOBLASTS. CANCER RESEARCH, 45(3), 1008–1014. -
Z-NUCLEOTIDE ACCUMULATION IN ERYTHROCYTES FROM LESCH-NYHAN PATIENTS
Sidi, Y., & Mitchell, B. S. (1985). Z-NUCLEOTIDE ACCUMULATION IN ERYTHROCYTES FROM LESCH-NYHAN PATIENTS. JOURNAL OF CLINICAL INVESTIGATION, 76(6), 2416–2419. -
EPIDEMIOLOGICAL ASPECTS OF NEOPLASTIC DISORDERS IN ISRAELI MIGRANT POPULATION .V. LYMPHOMAS
Modan, B., Goldman, B., Shani, M., Meytes, D., & Mitchell, B. S. (1969). EPIDEMIOLOGICAL ASPECTS OF NEOPLASTIC DISORDERS IN ISRAELI MIGRANT POPULATION .V. LYMPHOMAS. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 42(3), 375-? -
PURINE METABOLIZING ENZYMES AS PREDICTORS OF LYMPHOBLAST SENSITIVITY TO DEOXYADENOSINE
Mitchell, B. S., & Edwards, N. L. (1984). PURINE METABOLIZING ENZYMES AS PREDICTORS OF LYMPHOBLAST SENSITIVITY TO DEOXYADENOSINE. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 104(3), 414–424. -
PURINOGENIC IMMUNODEFICIENCY DISEASES - CLINICAL-FEATURES AND MOLECULAR MECHANISMS
Mitchell, B. S., & Kelley, W. N. (1980). PURINOGENIC IMMUNODEFICIENCY DISEASES - CLINICAL-FEATURES AND MOLECULAR MECHANISMS. ANNALS OF INTERNAL MEDICINE, 92(6), 826–831. -
PLASMA-MEMBRANE 5'-NUCLEOTIDASE AND OTHER PURINE ENZYMES IN MURINE LYMPHOCYTES
Edwards, N. L., Mitchell, B. S., Fox, I. H., & Mond, J. J. (1984). PLASMA-MEMBRANE 5'-NUCLEOTIDASE AND OTHER PURINE ENZYMES IN MURINE LYMPHOCYTES. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 165, 129–132. -
2'-DEOXYGUANOSINE TOXICITY FOR B-LYMPHOID AND MATURE T-LYMPHOID CELL-LINES IS MEDIATED BY GUANINE RIBONUCLEOTIDE ACCUMULATION
Sidi, Y., & Mitchell, B. S. (1984). 2'-DEOXYGUANOSINE TOXICITY FOR B-LYMPHOID AND MATURE T-LYMPHOID CELL-LINES IS MEDIATED BY GUANINE RIBONUCLEOTIDE ACCUMULATION. JOURNAL OF CLINICAL INVESTIGATION, 74(5), 1640–1648. -
ALTERATIONS IN ERYTHROCYTE ADENINE-NUCLEOTIDE POOLS RESULTING FROM 2'-DEOXYCOFORMYCIN THERAPY
Koller, C. A., & Mitchell, B. S. (1983). ALTERATIONS IN ERYTHROCYTE ADENINE-NUCLEOTIDE POOLS RESULTING FROM 2'-DEOXYCOFORMYCIN THERAPY. CANCER RESEARCH, 43(3), 1409–1414. -
S-ADENOSYLHOMOCYSTEINE CATABOLISM AND BASIS FOR ACQUIRED-RESISTANCE DURING TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN ALONE AND IN COMBINATION WITH 9-BETA-D-ARABINOFURANOSYLADENINE
Hershfield, M. S., Kredich, N. M., Koller, C. A., Mitchell, B. S., Kurtzberg, J., Kinney, T. R., & FALLETTA, J. M. (1983). S-ADENOSYLHOMOCYSTEINE CATABOLISM AND BASIS FOR ACQUIRED-RESISTANCE DURING TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN ALONE AND IN COMBINATION WITH 9-BETA-D-ARABINOFURANOSYLADENINE. CANCER RESEARCH, 43(7), 3451–3458. -
DEOXYRIBONUCLEOSIDE TRIPHOSPHATE ACCUMULATION BY LEUKEMIC-CELLS
Mitchell, B. S., Edwards, N. L., & Koller, C. A. (1983). DEOXYRIBONUCLEOSIDE TRIPHOSPHATE ACCUMULATION BY LEUKEMIC-CELLS. BLOOD, 62(2), 419–424. -
ADENOSINE-DEAMINASE DEFICIENCY WITH NORMAL IMMUNE FUNCTION - AN ACIDIC ENZYME MUTATION
Daddona, P. E., Mitchell, B. S., Meuwissen, H. J., Davidson, B. L., Wilson, J. M., & Koller, C. A. (1983). ADENOSINE-DEAMINASE DEFICIENCY WITH NORMAL IMMUNE FUNCTION - AN ACIDIC ENZYME MUTATION. JOURNAL OF CLINICAL INVESTIGATION, 72(2), 483–492. -
INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS
Kazmers, I. S., Mitchell, B. S., DADONNA, P. E., Wotring, L. L., Townsend, L. B., & Kelley, W. N. (1981). INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS. SCIENCE, 214(4525), 1137–1139. -
INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO
Mitchell, B. S., Koller, C. A., & Heyn, R. (1980). INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO. BLOOD, 56(3), 556–559. -
ATP DEPLETION AS A CONSEQUENCE OF ADENOSINE-DEAMINASE INHIBITION IN MAN
SIAW, M. F. E., Mitchell, B. S., Koller, C. A., Coleman, M. S., & HUTTON, J. J. (1980). ATP DEPLETION AS A CONSEQUENCE OF ADENOSINE-DEAMINASE INHIBITION IN MAN. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 77(10), 6157–6161. -
AN ASSAY OF DEOXYADENOSINE AND ADENOSINE IN HUMAN-PLASMA BY HPLC
Koller, C. A., Stetson, P. L., Nichamin, L. D., & Mitchell, B. S. (1980). AN ASSAY OF DEOXYADENOSINE AND ADENOSINE IN HUMAN-PLASMA BY HPLC. BIOCHEMICAL MEDICINE, 24(2), 179–184. -
MULTIPLE-MYELOMA - CURRENT CONCEPTS IN DIAGNOSIS AND MANAGEMENT
Paredes, J. M., & Mitchell, B. S. (1980). MULTIPLE-MYELOMA - CURRENT CONCEPTS IN DIAGNOSIS AND MANAGEMENT. MEDICAL CLINICS OF NORTH AMERICA, 64(4), 729–742. -
STRUCTURAL-ANALYSIS OF THE DEOXYCYTIDINE KINASE GENE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA AND RESISTANCE TO CYTOSINE-ARABINOSIDE
Flasshove, M., Strumberg, D., Ayscue, L., Mitchell, B. S., Tirier, C., Heit, W., … Schutte, J. (1994). STRUCTURAL-ANALYSIS OF THE DEOXYCYTIDINE KINASE GENE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA AND RESISTANCE TO CYTOSINE-ARABINOSIDE. LEUKEMIA, 8(5), 780–785. -
Regulation of low Km (Ecto-) 5'-nucleotidase gene expression in leukemic cells
Spychala, J., & Mitchell, B. S. (1994). Regulation of low Km (Ecto-) 5'-nucleotidase gene expression in leukemic cells. Presented at the 8th International Symposium on Purine and Pyrimidine Metabolism in Man, BLOOMINGTON,IN: PLENUM PRESS DIV PLENUM PUBLISHING CORP. -
TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE - EVIDENCE FOR A SINGLE FUNCTIONAL GENE IN MAMMALIAN-SPECIES
DAYTON, J. S., & Mitchell, B. S. (1993). TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE - EVIDENCE FOR A SINGLE FUNCTIONAL GENE IN MAMMALIAN-SPECIES. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 195(2), 897–901. -
CHARACTERIZATION OF THE DEOXYCYTIDINE KINASE PROMOTER IN HUMAN LYMPHOBLAST CELL-LINES
Chen, E. H., Johnson, E. E., Vetter, S. M., & Mitchell, B. S. (1995). CHARACTERIZATION OF THE DEOXYCYTIDINE KINASE PROMOTER IN HUMAN LYMPHOBLAST CELL-LINES. JOURNAL OF CLINICAL INVESTIGATION, 95(4), 1660–1668. -
GTP DEPLETION INDUCED BY IMP DEHYDROGENASE INHIBITORS BLOCKS RNA-PRIMED DNA-SYNTHESIS
Catapano, C. V., DAYTON, J. S., Mitchell, B. S., & Fernandes, D. J. (1995). GTP DEPLETION INDUCED BY IMP DEHYDROGENASE INHIBITORS BLOCKS RNA-PRIMED DNA-SYNTHESIS. MOLECULAR PHARMACOLOGY, 47(5), 948–955. -
RECOMBINANT HUMAN INOSINE MONOPHOSPHATE DEHYDROGENASE TYPE-I AND TYPE-II PROTEINS - PURIFICATION AND CHARACTERIZATION OF INHIBITOR BINDING
Hager, P. W., COLLART, F. R., HUBERMAN, E., & Mitchell, B. S. (1995). RECOMBINANT HUMAN INOSINE MONOPHOSPHATE DEHYDROGENASE TYPE-I AND TYPE-II PROTEINS - PURIFICATION AND CHARACTERIZATION OF INHIBITOR BINDING. BIOCHEMICAL PHARMACOLOGY, 49(9), 1323–1329. -
ASSIGNMENT OF THE HUMAN TYPE-I IMP DEHYDROGENASE GENE (IMPDH1) TO CHROMOSOME 7Q31.3-Q32
Gu, J. J., KAISERROGERS, K., Rao, K., & Mitchell, B. S. (1994). ASSIGNMENT OF THE HUMAN TYPE-I IMP DEHYDROGENASE GENE (IMPDH1) TO CHROMOSOME 7Q31.3-Q32. GENOMICS, 24(1), 179–181. -
CHARACTERIZATION OF THE HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE TYPE-II GENES
Zimmermann, A. G., Spychala, J., & Mitchell, B. S. (1995). CHARACTERIZATION OF THE HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE TYPE-II GENES. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(12), 6808–6814. -
EFFECTS OF HUMAN T-LYMPHOCYTE ACTIVATION ON INOSINE MONOPHOSPHATE DEHYDROGENASE EXPRESSION
DAYTON, J. S., LINDSTEN, T., Thompson, C. B., & Mitchell, B. S. (1994). EFFECTS OF HUMAN T-LYMPHOCYTE ACTIVATION ON INOSINE MONOPHOSPHATE DEHYDROGENASE EXPRESSION. JOURNAL OF IMMUNOLOGY, 152(3), 984–991. -
HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - STUDIES IN ERYTHROID CELL-LINES AND TRANSGENIC MICE
Chen, E. H., & Mitchell, B. S. (1994). HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - STUDIES IN ERYTHROID CELL-LINES AND TRANSGENIC MICE. BLOOD, 84(7), 2346–2353. -
IMP DEHYDROGENASE INHIBITORS AS IMMUNOMODULATORS
Mitchell, B. S., DAYTON, J. S., Turka, L. A., & Thompson, C. B. (1993). IMP DEHYDROGENASE INHIBITORS AS IMMUNOMODULATORS. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 685, 217–224. -
HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - EVIDENCE FOR A CIS-ACTING MUTATION
Chen, E. H., TARTAGLIA, A. P., & Mitchell, B. S. (1993). HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - EVIDENCE FOR A CIS-ACTING MUTATION. AMERICAN JOURNAL OF HUMAN GENETICS, 53(4), 889–893. -
REGULATION OF HUMAN DEOXYCYTIDINE KINASE EXPRESSION
Mitchell, B. S., Song, J. J., Johnson, E. E., Chen, E., & DAYTON, J. S. (1993). REGULATION OF HUMAN DEOXYCYTIDINE KINASE EXPRESSION. Presented at the 33RD SYMP ON REGULATION OF ENZYME ACTIVITY AND SYNTHESIS IN NORMAL AND NEOPLASTIC TISSUES, INDIANAPOLIS,IN: PERGAMON PRESS LTD. -
GENOMIC STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN DEOXYCYTIDINE KINASE GENE
Song, J. J., Walker, S., Chen, E., Johnson, E. E., Spychala, J., Gribbin, T., & Mitchell, B. S. (1993). GENOMIC STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN DEOXYCYTIDINE KINASE GENE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(2), 431–434. -
Cloning of human adenosine kinase cDNA: Sequence similarity to microbial ribokinases and fructokinases
Spychala, J., Datta, N. S., Takabayashi, K., Datta, M., Fox, I. H., Gribbin, T., & Mitchell, B. S. (1996). Cloning of human adenosine kinase cDNA: Sequence similarity to microbial ribokinases and fructokinases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93(3), 1232–1237. -
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
Manome, Y., Wen, P. Y., Dong, Y. H., Tanaka, T., Mitchell, B. S., Kufe, D. W., & Fine, H. A. (1996). Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. NATURE MEDICINE, 2(5), 567–573. -
Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity
Hapke, D. M., Stegmann, A. P. A., & Mitchell, B. S. (1996). Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity. CANCER RESEARCH, 56(10), 2343–2347. -
Inosine monophosphate dehydrogenase expression: Transcriptional regulation of the type I and type II genes
Zimmermann, A., Gu, J. J., Spychala, J., & Mitchell, B. S. (1996). Inosine monophosphate dehydrogenase expression: Transcriptional regulation of the type I and type II genes. Presented at the 36th Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues, INDIANAPOLIS,IN: PERGAMON PRESS LTD. -
Regulation of the human inosine monophosphate dehydrogenase type I gene - Utilization of alternative promoters
Gu, J. J., Spychala, J., & Mitchell, B. S. (1997). Regulation of the human inosine monophosphate dehydrogenase type I gene - Utilization of alternative promoters. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(7), 4458–4466. -
Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell difference - Changes in expression pattern of adenosine kinase, adenosine deaminase, and 5'-nucleotidase
Spychala, J., Mitchell, B. S., & BARANKIEWICZ, J. (1997). Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell difference - Changes in expression pattern of adenosine kinase, adenosine deaminase, and 5'-nucleotidase. JOURNAL OF IMMUNOLOGY, 158(10), 4947–4952. -
Cellular delivery of nucleoside diphosphates: A prodrug approach
Kang, S. H., Sinhababu, A. K., Cory, J. G., Mitchell, B. S., Thakker, D. R., & Cho, M. J. (1997). Cellular delivery of nucleoside diphosphates: A prodrug approach. PHARMACEUTICAL RESEARCH, 14(6), 706–712. -
Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells - Role for a novel 5' palindromic octamer sequence
Zimmermann, A. G., Wright, K. L., Ting, J. P. Y., & Mitchell, B. S. (1997). Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells - Role for a novel 5' palindromic octamer sequence. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(36), 22913–22923. -
Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes
Laliberte, J., Yee, A., Xiong, Y., & Mitchell, B. S. (1998). Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. BLOOD, 91(8), 2896–2904. -
Lectin histochemistry of human leukaemic mast cells (HMC-1) transplanted into severe combined immunodeficient (scid) mice
Schumacher, U., Van Damme, E. J. M., Peumans, W. J., Butterfield, J. H., & Mitchell, B. S. (1998). Lectin histochemistry of human leukaemic mast cells (HMC-1) transplanted into severe combined immunodeficient (scid) mice. ACTA HISTOCHEMICA, 100(1), 1–9. -
Inosine-5 '-monophosphate dehydrogenase: Regulation of expression and role in cellular proliferation and T lymphocyte activation
Zimmermann, A. G., Gu, J. J., Laliberte, J., & Mitchell, B. S. (1998). Inosine-5 '-monophosphate dehydrogenase: Regulation of expression and role in cellular proliferation and T lymphocyte activation. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 61, 61, 181–209. -
Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response
Gandhi, V., Plunkett, W., Rodriguez, C. O., Nowak, B. J., Du, M., Ayres, M., … Keating, M. J. (1998). Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response. JOURNAL OF CLINICAL ONCOLOGY, 16(11), 3607–3615. -
The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research
Mitchell, B. S., & Schumacher, U. (1999). The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research. HISTOLOGY AND HISTOPATHOLOGY, 14(1), 217–226. -
The effect of phenylthiourea on melanogenesis of Fundulus Heteroclitus
The effect of phenylthiourea on melanogenesis of Fundulus Heteroclitus. (1966). Biological Bulletin, (131). -
Molecular basis for elevated adenosine deaminase activity in a kindred with hemolytic anemia
Molecular basis for elevated adenosine deaminase activity in a kindred with hemolytic anemia. (1987). J Clin Invest. -
Nelarabing induces complete remissions in adults with relapsed or refractory t-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia group B study 19801
Nelarabing induces complete remissions in adults with relapsed or refractory t-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia group B study 19801. (2007). Blood, 109(12). -
Deficiencies of adenosine deaminase and purine nucleoside phosphorylase: Implimcations for immunopharmacology
Deficiencies of adenosine deaminase and purine nucleoside phosphorylase: Implimcations for immunopharmacology. (1982). Med Gr Rounds, (1). -
Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture
Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture. (1975). Proc Nat Acad Sci (USA), (72). -
Effect of lysosphatidic acid acyltransferase-B inhibition in acute luekemia
Effect of lysosphatidic acid acyltransferase-B inhibition in acute luekemia. (2006). Leu Res, 30(8). -
Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype
Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype. (1985). Br J Haemat, (61). -
Identification of an Apa I polymorphism within the human adenosine deaminase gene
Identification of an Apa I polymorphism within the human adenosine deaminase gene. (1989). Nucl Acids Res, (17). -
Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes
Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. (1998). Blood. -
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar proteins
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar proteins. (2008). Leuk Res, 32(1). -
Uridine diphosphate galactose 4'-epimerase deficiency
Uridine diphosphate galactose 4'-epimerase deficiency. (1976). Helv Paediat Acta, IV(31). -
Adult T-cell leukaemia-lymphoma with unusual phenotype
Adult T-cell leukaemia-lymphoma with unusual phenotype. (1982). The Lancet (Letter). -
Transcriptional regulationof the IMPDH type I and II genes
Transcriptional regulationof the IMPDH type I and II genes. (1996). Adv Enzyme Regul, (36). -
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. (2008). Biochem Biophys Acta, 1782(1). -
Granulocyte and erythroid colony forming cells from rat marrow: Studies of physical and cell cycle characteristics and competition for expression
Granulocyte and erythroid colony forming cells from rat marrow: Studies of physical and cell cycle characteristics and competition for expression. (1975). In Erythropoiesis, Nakao K, Fisher J, Pakaku F (Eds) University Park Press. -
Erythrocyte ATP a dATP measurements predict toxicity following 2'-deoxycoformycin therapy
Erythrocyte ATP a dATP measurements predict toxicity following 2'-deoxycoformycin therapy. (1984). Cancer Treat Symp, (2). -
Development of an in vitro model system to study the physiologic effects and toxicities of immunosuppressants
Development of an in vitro model system to study the physiologic effects and toxicities of immunosuppressants. (1991). Alternative Methods in Toxicology, 8. -
A 73 year-old woman with anemia and thrombocytopenia
A 73 year-old woman with anemia and thrombocytopenia. (1996). J Am Ger Soc, (44). -
Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib
Huang, M., Thomas, D., Li, M. X., Feng, W., Chan, S. M., Majeti, R., & Mitchell, B. S. (2013). Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. LEUKEMIA, 27(10), 1970–80. -
Genetic and biochemical biomarkers of IMPDH inhibition in phase I dose escalation of AVN-944 for hematologic malignancies.
Strovel, J. W., Chakiath, M., Natarajan, P., Lawrence, T., Zuck, K. M., Urbani, L., … Bol, D. K. (2006). Genetic and biochemical biomarkers of IMPDH inhibition in phase I dose escalation of AVN-944 for hematologic malignancies. BLOOD, 108(11), 731A–732A. -
Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA
Le Xuan Truong Nguyen, L. X. T., & Mitchell, B. S. (2013). Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(51), 20681–86. -
Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies
Kisor, D. F., Plunkett, W., Kurtzberg, J., Mitchell, B., Hodge, J. P., Ernst, T., … Gandhi, V. (2000). Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 18(5), 995–1003. -
Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells.
Nguyen, L. X. T., Chan, S. M., Ngo, T. D., Raval, A., Kim, K. K., Majeti, R., & Mitchell, B. S. (2014). Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells. Blood, 124(4), 579–89. -
Regulation of ribosomal gene expression in cancer.
Nguyen, L. X. T., Raval, A., Garcia, J. S., & Mitchell, B. S. (2015). Regulation of ribosomal gene expression in cancer. Journal of Cellular Physiology, 230(6), 1181–88. -
Effect of CAL-101, a PI3K delta inhibitor, on ribosomal rna synthesis and cell proliferation in acute myeloid leukemia cells
Nguyen, L. X. T., Sesay, A., & Mitchell, B. S. (2014). Effect of CAL-101, a PI3K delta inhibitor, on ribosomal rna synthesis and cell proliferation in acute myeloid leukemia cells. BLOOD CANCER JOURNAL, 4. -
Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1.
Nguyen, L. X. T., Lee, Y., Urbani, L., Utz, P. J., Hamburger, A. W., Sunwoo, J. B., & Mitchell, B. S. (2015). Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. Blood, 125(16), 2519–29. -
How do differences in treatment impact racial and ethnic disparities in acute myeloid leukemia?
Patel, M. I., Ma, Y., Mitchell, B., & Rhoads, K. F. (2015). How do differences in treatment impact racial and ethnic disparities in acute myeloid leukemia? Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 24(2), 344–49. -
Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice.
Raval, A., Behbehani, G. K., Nguyen, L. X. T., Thomas, D., Kusler, B., Garbuzov, A., … Mitchell, B. S. (2015). Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. PloS One, 10(7). -
Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species.
Garcia, J. S., Huang, M., Medeiros, B. C., & Mitchell, B. S. (2016). Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species. Clinical Cancer Research , 22(8), 1978–88. -
Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells.
Nguyen, L. X. T., Zhu, L., Lee, Y., Ta, L., & Mitchell, B. S. (2016). Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells. Clinical Cancer Research , 22(13), 3320–27. -
Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells.
Huang, M., Garcia, J. S., Thomas, D., Zhu, L., Nguyen, L. X. T., Chan, S. M., … Mitchell, B. S. (2016). Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget. -
Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Le Xuan Truong Nguyen, L. X. T., Lee, Y., Urbani, L., Utz, P. J., Hamburger, A. W., Sunwoo, J. B., & Mitchell, B. S. (2015). Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. BLOOD, 125(16), 2519–29. -
Regulation of Ribosomal Gene Expression in Cancer
Le Xuan Truong Nguyen, L. X. T., Raval, A., Garcia, J. S., & Mitchell, B. S. (2015). Regulation of Ribosomal Gene Expression in Cancer. JOURNAL OF CELLULAR PHYSIOLOGY, 230(6), 1181–88. -
Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Le Xuan Truong Nguyen, L. X. T., Zhu, L., Lee, Y., Ta, L., & Mitchell, B. S. (2016). Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells. CLINICAL CANCER RESEARCH, 22(13), 3320–27. -
Future cancer research priorities in the USA: a Lancet Oncology Commission
Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., … Yung, A. (2017). Future cancer research priorities in the USA: a Lancet Oncology Commission. LANCET ONCOLOGY, 18(11), E653–E706. -
Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells.
Huang, M., Zhu, L., Garcia, J. S., Li, M. X., Gentles, A. J., & Mitchell, B. S. (2018). Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells. Oncotarget, 9(14), 11665–76.
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