Euan A. Ashley

Cardiologist

Born and raised in Scotland, Euan Angus Ashley graduated with 1st class Honors in Physiology and Medicine from the University of Glasgow. He completed medical residency and a PhD in molecular cardiology at the University of Oxford before moving to Stanford University where he trained in cardiology and advanced heart failure joining the faculty in 2006. His group is focused on the application of genomics to medicine. In 2010, he led the team that carried out the first clinical interpretation of a human genome. The paper published in the Lancet was the focus of over 300 news stories, became one of the most cited articles in clinical medicine that year, and is currently featured in the Genome Exhibition at the Smithsonian in DC. The team extended the approach in 2011 to a family of four and now routinely apply genome sequencing to the diagnosis of patients at Stanford hospital where Dr Ashley directs the Clinical Genome Service and the Center for Inherited Cardiovascular Disease. In 2013, Dr Ashley was recognized at the White House 'Data to Knowledge to Action' event for his contributions to Personalized Medicine. Dr Ashley is a recipient of the National Innovation Award from the American Heart Association (AHA) and a National Institutes of Health (NIH) Director’s New Innovator Award. He is a member of the AHA Council on Functional Genomics, and the Institute of Medicine (IOM) of the National Academy of Sciences Roundtable on Translating Genomic-Based Research for Health. He is a peer reviewer for the NIH and the AHA as well as journals including Nature, the New England Journal of Medicine, the Lancet and the Journal of Clinical Investigation. He is co-founder of Personalis, Inc, a Menlo Park based genetic diagnostics company.

Father to three young Americans, in his ‘spare’ time, he tries to understand American football, plays the saxophone, and conducts research on the health benefits of single malt Scotch whisky.

Heart Failure and Cardiomyopathy Clinic

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Heart Transplant Program

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Hypertrophic Cardiomyopathy Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Center for Inherited Cardiovascular Disease

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-721-4363
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Internship: University of Glasgow (1997) Scotland

Medical Education: University of Glasgow (1996) Scotland

Residency: University of Oxford (1999) UK

Fellowship: University of Oxford (2002) UK

Fellowship: Stanford University Medical Center (2006) CA

DPhil, University of Oxford, Molecular Cardiology (2002)

MRCP (UK), Royal College of Physicians (UK), Medicine (1999)

MB ChB, University of Glasgow, Medicine (1996)

BSc (Hons), University of Glasgow, Physiology (1993)

Honors & Awards

NIH Director's New Innovator Award, National Institutes of Health (2009)

Innovative Research Award, American Heart Association (2008)

Faculty Scholar, Donald E. and Delia B. Baxter Foundation (2009)

Career Development Award (K08), National Institutes of Health (2006)

Western Affiliates Young Investigator Award, American Heart Association (2004)

Cardiovascular Medicine Basic Science Award, Stanford University (2004)

Young Investigator Award (Basic), Astra-Zeneca (2003)

Young Investigator Award, European Society of Cardiology (2002)

Young Investigator Prize in Cardiovascular Medicine, UK Medical Research Society (2002)

Administrative Appointments

Co-Director, Clinical Genomics Service, 2013

Director, Stanford Center for Inherited Cardiovascular Disease, 2010

Co-Director, Stanford Research Training Program in Myocardial Biology, 2010

Member, Institute of Medicine Roundtable on Translating Genomic-based Research for Health, 2012

Leadership committee, AHA Council on Functional Genomics and Translational Biology, 2009

Director, Stanford Cardiopulmonary Exercise Testing Laboratory, 2007

Director, Stanford Hypertrophic Cardiomyopathy Center, 2006

Deputy Director, Stanford Cardiovascular Institute, 2010

Executive Editor, Journal of Cardiovascular Translational Research, 2007

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Guidelines for investigating causality of sequence variants in human disease
MacArthur, D. G., Manolio, T. A., Dimmock, D. P., Rehm, H. L., Shendure, J., & Gunter, C. (2014). Guidelines for investigating causality of sequence variants in human disease. NATURE, 508(7497), 469-476.

Clinical interpretation and implications of whole-genome sequencing.
Dewey, F. E., Grove, M. E., Pan, C., Goldstein, B. A., Bernstein, J. A., & Quertermous, T. (2014). Clinical interpretation and implications of whole-genome sequencing. JAMA-the journal of the American Medical Association, 311(10), 1035-1045.

APJ acts as a dual receptor in cardiac hypertrophy
Scimia, M. C., Hurtado, C., Ray, S., Metzler, S., Wei, K., & Ruiz-Lozano, P. (2012). APJ acts as a dual receptor in cardiac hypertrophy. NATURE, 488(7411), 394-398.

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
Chen, R., Mias, G. I., Li-Pook-Than, J., Jiang, L., Lam, H. Yk., & Snyder, M. (2012). Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes. CELL, 148(6), 1293-1307.

Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
Dewey, F. E., Chen, R., Cordero, S. P., Ormond, K. E., Caleshu, C., & Ashley, E. A. (2011). Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence. PLOS GENETICS, 7(9).

Clinical assessment incorporating a personal genome
Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., & Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525-1535.

Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension
Perez, V. A. J., Yuan, K., Lyuksyutova, M. A., Dewey, F., Orcholski, M. E., & Zamanian, R. T. (2014). Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189(10), 1260-1272.

Latent Obstruction and Left Atrial Size Are Predictors of Clinical Deterioration Leading to Septal Reduction in Hypertrophic Cardiomyopathy
Finocchiaro, G., Haddad, F., Pavlovic, A., Sinagra, G., Schnittger, I., & Ashley, E. (2014). Latent Obstruction and Left Atrial Size Are Predictors of Clinical Deterioration Leading to Septal Reduction in Hypertrophic Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 20(4), 236-243.

Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement.
Finocchiaro, G., Murphy, D., Pavlovic, A., Haddad, F., Shiran, H., & Knowles, J. W. (2014). Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement. Echocardiography (Mount Kisco, N.Y.), 31(3), E80-4.

A neural network approach to predicting outcomes in heart failure using cardiopulmonary exercise testing
Myers, J., de Souza, C. R., Borghi-Silva, A., Guazzi, M., Chase, P., & Arena, R. (2014). A neural network approach to predicting outcomes in heart failure using cardiopulmonary exercise testing. INTERNATIONAL JOURNAL OF CARDIOLOGY, 171(2), 265-269.

Rat model of veno-arterial extracorporeal membrane oxygenation.
Ali, A. A., Downey, P., Singh, G., Qi, W., George, I., & Ali, Z. A. (2014). Rat model of veno-arterial extracorporeal membrane oxygenation. Journal of translational medicine, 12, 37-?.

Identification of a New Target of miR-16, Vacuolar Protein Sorting 4a.
Adhikari, N., Guan, W., Capaldo, B., Mackey, A. J., Carlson, M., & Hall, J. L. (2014). Identification of a New Target of miR-16, Vacuolar Protein Sorting 4a. PloS one, 9(7).

Molecular Diagnosis of Long-QT syndrome at 10 Days of Life by Rapid Whole Genome Sequencing.
Priest, J. R., Ceresnak, S. R., Dewey, F. E., Malloy-Walton, L. E., Dunn, K., & Ashley, E. A. (2014). Molecular Diagnosis of Long-QT syndrome at 10 Days of Life by Rapid Whole Genome Sequencing. Heart rhythm : the official journal of the Heart Rhythm Society.

The prognostic significance of heart rate recovery is not dependent upon maximal effort in patients with heart failure
Cahalin, L. P., Forman, D. E., Chase, P., Guazzi, M., Myers, J., & Arena, R. (2013). The prognostic significance of heart rate recovery is not dependent upon maximal effort in patients with heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 168(2), 1496-1501.

Race differences in ventricular remodeling and function among college football players.
Haddad, F., Peter, S., Hulme, O., Liang, D., Schnittger, I., & Ashley, E. A. (2013). Race differences in ventricular remodeling and function among college football players. American journal of cardiology, 112(1), 128-134.

Taming Rare Variation With Known Biology in Long QT Syndrome.
Perez, M. V., & Ashley, E. A. (2013). Taming Rare Variation With Known Biology in Long QT Syndrome. Circulation. Cardiovascular genetics, 6(3), 227-229.

Impact of Cardiorespiratory Fitness on the Obesity Paradox in Patients With Heart Failure
Lavie, C. J., Cahalin, L. P., Chase, P., Myers, J., Bensimhon, D., & Arena, R. (2013). Impact of Cardiorespiratory Fitness on the Obesity Paradox in Patients With Heart Failure. MAYO CLINIC PROCEEDINGS, 88(3), 251-258.

Validation of a cardiopulmonary exercise test score in heart failure.
Myers, J., Oliveira, R., Dewey, F., Arena, R., Guazzi, M., & Forman, D. E. (2013). Validation of a cardiopulmonary exercise test score in heart failure. Circulation. Heart failure, 6(2), 211-218.

Cardiopulmonary and Noninvasive Hemodynamic Responses to Exercise Predict Outcomes in Heart Failure
Myers, J., Wong, M., Adhikarla, C., Boga, M., Challa, S., & Ashley, E. A. (2013). Cardiopulmonary and Noninvasive Hemodynamic Responses to Exercise Predict Outcomes in Heart Failure. JOURNAL OF CARDIAC FAILURE, 19(2), 101-107.

A Clinical Approach to Inherited Hypertrophy The Use of Family History in Diagnosis, Risk Assessment, and Management
Dunn, K. E., Caleshu, C., Cirino, A. L., Ho, C. Y., & Ashley, E. A. (2013). A Clinical Approach to Inherited Hypertrophy The Use of Family History in Diagnosis, Risk Assessment, and Management. CIRCULATION-CARDIOVASCULAR GENETICS, 6(1), 118-131.

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Lan, F., Lee, A. S., Liang, P., Sanchez-Freire, V., Nguyen, P. K., & Wu, J. C. (2013). Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. CELL STEM CELL, 12(1), 101-113.

A meta-analysis of the prognostic significance of cardiopulmonary exercise testing in patients with heart failure.
Cahalin, L. P., Chase, P., Arena, R., Myers, J., Bensimhon, D., & Guazzi, M. (2013). A meta-analysis of the prognostic significance of cardiopulmonary exercise testing in patients with heart failure. Heart failure reviews, 18(1), 79-94.

Cardiac Structural and Sarcomere Genes Associated With Cardiomyopathy Exhibit Marked Intolerance of Genetic Variation
Pan, S., Caleshu, C. A., Dunn, K. E., Foti, M. J., Moran, M. K., & Ashley, E. A. (2012). Cardiac Structural and Sarcomere Genes Associated With Cardiomyopathy Exhibit Marked Intolerance of Genetic Variation. CIRCULATION-CARDIOVASCULAR GENETICS, 5(6), 602-610.

Prognostic value of capnography during rest and exercise in patients with heart failure.
Arena, R., Guazzi, M., Myers, J., Chase, P., Bensimhon, D., & Forman, D. E. (2012). Prognostic value of capnography during rest and exercise in patients with heart failure. Congestive heart failure (Greenwich, Conn.), 18(6), 302-307.

Ventilatory Power A Novel Index That Enhances Prognostic Assessment of Patients With Heart Failure
Forman, D. E., Guazzi, M., Myers, J., Chase, P., Bensimhon, D., & Arena, R. (2012). Ventilatory Power A Novel Index That Enhances Prognostic Assessment of Patients With Heart Failure. CIRCULATION-HEART FAILURE, 5(5), 621-626.

In Situ Optical Mapping of Voltage and Calcium in the Heart
Lee, P., Taghavi, F., Yan, P., Ewart, P., Ashley, E. A., & Woods, C. E. (2012). In Situ Optical Mapping of Voltage and Calcium in the Heart. PLOS ONE, 7(8).

A public resource facilitating clinical use of genomes
Ball, M. P., Thakuria, J. V., Zaranek, A. W., Clegg, T., Rosenbaum, A. M., & Church, G. M. (2012). A public resource facilitating clinical use of genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(30), 11920-11927.

Personalized medicine: hope or hype?
Salari, K., Watkins, H., & Ashley, E. A. (2012). Personalized medicine: hope or hype?. EUROPEAN HEART JOURNAL, 33(13), 1564-U29.

The Prognostic Utility of Cardiopulmonary Exercise Testing Stands the Test of Time in Patients With Heart Failure
Arena, R., Guazzi, M., Myers, J., Chase, P., Bensimhon, D., & Forman, D. E. (2012). The Prognostic Utility of Cardiopulmonary Exercise Testing Stands the Test of Time in Patients With Heart Failure. JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 32(4), 198-202.

Prognostic Implications of Q Waves and T-Wave Inversion Associated With Early Repolarization
Uberoi, A., Sallam, K., Perez, M., Jain, N. A., Ashley, E., & Froelicher, V. (2012). Prognostic Implications of Q Waves and T-Wave Inversion Associated With Early Repolarization. MAYO CLINIC PROCEEDINGS, 87(7), 614-619.

Cell-Intrinsic Functional Effects of the alpha-Cardiac Myosin Arg-403-Gln Mutation in Familial Hypertrophic Cardiomyopathy
Chuan, P., Sivaramakrishnan, S., Ashley, E. A., & Spudich, J. A. (2012). Cell-Intrinsic Functional Effects of the alpha-Cardiac Myosin Arg-403-Gln Mutation in Familial Hypertrophic Cardiomyopathy. BIOPHYSICAL JOURNAL, 102(12), 2782-2790.

Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells
Wang, I.-N. E., Wang, X., Ge, X., Anderson, J., Ho, M., & Yang, P. C. (2012). Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells. PLOS ONE, 7(6).

Whole-Genome Sequencing in Personalized Therapeutics
Cordero, P., & Ashley, E. A. (2012). Whole-Genome Sequencing in Personalized Therapeutics. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(6), 1001-1009.

Systems-Based Approaches to Cardiovascular Biomarker Discovery
Azuaje, F. J., Dewey, F. E., Brutsaert, D. L., Devaux, Y., Ashley, E. A., & Wagner, D. R. (2012). Systems-Based Approaches to Cardiovascular Biomarker Discovery. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 360-367.

Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges
Knowles, J. W., Assimes, T. L., Kiernan, M., Pavlovic, A., Goldstein, B. A., & Ioannidis, J. Pa. (2012). Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 368-376.

Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Sun, N., Yazawa, M., Liu, Jw., Han, L., Sanchez-Freire, V., & Wu, J. C. (2012). Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy. SCIENCE TRANSLATIONAL MEDICINE, 4(130).

The prognostic value of early repolarization with ST-segment elevation in African Americans
Perez, M. V., Uberoi, A., Jain, N. A., Ashley, E., Turakhia, M. P., & Froelicher, V. (2012). The prognostic value of early repolarization with ST-segment elevation in African Americans. HEART RHYTHM, 9(4), 558-565.

DNA Sequencing Clinical Applications of New DNA Sequencing Technologies
Dewey, F. E., Pan, S., Wheeler, M. T., Quake, S. R., & Ashley, E. A. (2012). DNA Sequencing Clinical Applications of New DNA Sequencing Technologies. CIRCULATION, 125(7), 931-944.

Exercise oscillatory ventilation reflects diminished quality of life and perceived functional capacity in patients with heart failure
Arena, R., Guazzi, M., Myers, J., Chase, P., Bensimhon, D., & Forman, D. E. (2011). Exercise oscillatory ventilation reflects diminished quality of life and perceived functional capacity in patients with heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 153(2), 213-214.

Early Repolarization in an Ambulatory Clinical Population
Uberoi, A., Jain, N. A., Perez, M., Weinkopff, A., Ashley, E., & Froelicher, V. (2011). Early Repolarization in an Ambulatory Clinical Population. CIRCULATION, 124(20), 2208-2214.

The Impact of ST Elevation on Athletic Screening
Leo, T., Uberoi, A., Jain, N. A., Garza, D., Chowdhury, S., & Froelicher, V. (2011). The Impact of ST Elevation on Athletic Screening. CLINICAL JOURNAL OF SPORT MEDICINE, 21(5), 433-440.

Interpretation of the Electrocardiogram of Young Athletes
Uberoi, A., Stein, R., Perez, M. V., Freeman, J., Wheeler, M., & Froelicher, V. (2011). Interpretation of the Electrocardiogram of Young Athletes. CIRCULATION, 124(6), 746-757.

Hearts From DCD Donors Display Acceptable Biventricular Function After Heart Transplantation in Pigs
Ali, A. A., White, P., Xiang, B., Lin, H.-Y., Tsui, S. S., & Freed, D. H. (2011). Hearts From DCD Donors Display Acceptable Biventricular Function After Heart Transplantation in Pigs. AMERICAN JOURNAL OF TRANSPLANTATION, 11(8), 1621-1632.

Systems biology of heart failure, challenges and hopes
Dewey, F. E., Wheeler, M. T., & Ashley, E. A. (2011). Systems biology of heart failure, challenges and hopes. CURRENT OPINION IN CARDIOLOGY, 26(4), 314-321.

Genetic Analysis in Cardiovascular Disease A Clinical Perspective
Ho, E., Bhindi, R., Ashley, E. A., & Figtree, G. A. (2011). Genetic Analysis in Cardiovascular Disease A Clinical Perspective. CARDIOLOGY IN REVIEW, 19(2), 81-89.

The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for prediction
Haddad, F., Vrtovec, B., Ashley, E. A., Deschamps, A., Haddad, H., & Denault, A. Y. (2011). The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for prediction. CURRENT OPINION IN CARDIOLOGY, 26(2), 123-131.

Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure
Dewey, F. E., Perez, M. V., Wheeler, M. T., Watt, C., Spin, J., & Ashley, E. A. (2011). Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure. CIRCULATION-CARDIOVASCULAR GENETICS, 4(1), 26-U129.

BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
Perez, V. A. J., Ali, Z., Alastalo, T.-P., Ikeno, F., Sawada, H., & Rabinovitch, M. (2011). BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. JOURNAL OF CELL BIOLOGY, 192(1), 171-188.

Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks
Dudley, J. T., Schadt, E., Sirota, M., Butte, A. J., & Ashley, E. (2010). Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 3(5), 438-447.

Chromatin regulation by Brg1 underlies heart muscle development and disease
Hang, C. T., Yang, J., Han, P., Cheng, H.-L., Shang, C., & Chang, C.-P. (2010). Chromatin regulation by Brg1 underlies heart muscle development and disease. NATURE, 466(7302), 62-U74.

Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse
Kojima, Y., Kundu, R. K., Cox, C. M., Leeper, N. J., Anderson, J. A., & Quertermous, T. (2010). Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. CARDIOVASCULAR RESEARCH, 87(1), 156-165.

Challenges in the clinical application of whole-genome sequencing
Ormond, K. E., Wheeler, M. T., Hudgins, L., Klein, T. E., Butte, A. J., & Greely, H. T. (2010). Challenges in the clinical application of whole-genome sequencing. LANCET, 375(9727), 1749-1751.

Measurement Precision in the Optimization of Cardiac Resynchronization Therapy
Turcott, R. G., Witteles, R. M., Wang, P. J., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2010). Measurement Precision in the Optimization of Cardiac Resynchronization Therapy. CIRCULATION-HEART FAILURE, 3(3), 395-404.

Defining the Limits of Athlete's Heart Implications for Screening in Diverse Populations
Sedehi, D., & Ashley, E. A. (2010). Defining the Limits of Athlete's Heart Implications for Screening in Diverse Populations. CIRCULATION, 121(9), 1066-1068.

Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes
Wheeler, M. T., Heidenreich, P. A., Froelicher, V. F., Hlatky, M. A., & Ashley, E. A. (2010). Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes. ANNALS OF INTERNAL MEDICINE, 152(5), 276-W91.

New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy
Haddad, F., Ashley, E., & Michelakis, E. D. (2010). New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy. CURRENT OPINION IN CARDIOLOGY, 25(2), 131-140.

Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes
Le, V.-V., Wheeler, M. T., Mandic, S., Dewey, F., Fonda, H., & Froelicher, V. (2010). Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes. CLINICAL JOURNAL OF SPORT MEDICINE, 20(2), 98-105.

A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy
Wheeler, M., Pavlovic, A., deGoma, E., Salisbury, H., Brown, C., & Ashley, E. A. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2(4), 381-391.

Insights into Human beta-Cardiac Myosin Function from Single Molecule and Single Cell Studies
Sivaramakrishnan, S., Ashley, E., Leinwand, L., & Spudich, J. A. (2009). Insights into Human beta-Cardiac Myosin Function from Single Molecule and Single Cell Studies. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2(4), 426-440.

Endogenous regulation of cardiovascular function by apelin-APJ
Charo, D. N., Ho, M., Fajardo, G., Kawana, M., Kundu, R. K., & Quertermous, T. (2009). Endogenous regulation of cardiovascular function by apelin-APJ. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297(5), H1904-H1913.

The Medical Device Safety Act of 2009: Clarifying Preemption
Turcott, R. G., & Ashley, E. A. (2009). The Medical Device Safety Act of 2009: Clarifying Preemption. AMERICAN JOURNAL OF THERAPEUTICS, 16(6), 471-474.

Electrocardiographic predictors of atrial fibrillation
Perez, M. V., Dewey, F. E., Marcus, R., Ashley, E. A., Al-Ahmad, A. A., & Froelicher, V. F. (2009). Electrocardiographic predictors of atrial fibrillation. AMERICAN HEART JOURNAL, 158(4), 622-628.

Untitled
Turcott, R. G., Das, A. K., & Ashley, E. A. (2009). Untitled. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 32(10), 1360-1361.

Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy
Le, V.-V., Perez, M. V., Wheeler, M. T., Myers, J., Schnittger, I., & Ashley, E. A. (2009). Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy. AMERICAN HEART JOURNAL, 158(3), E27-E34.

The ageing athlete: screening prior to vigorous exertion in asymptomatic adults without known cardiovascular disease
Freeman, J., Froelicher, V., & Ashley, E. (2009). The ageing athlete: screening prior to vigorous exertion in asymptomatic adults without known cardiovascular disease. BRITISH JOURNAL OF SPORTS MEDICINE, 43(9), 696-701.

Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation
Leeper, N. J., Tedesco, M. M., Kojima, Y., Schultz, G. M., Kundu, R. K., & Quertermous, T. (2009). Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296(5), H1329-H1335.

Should the exercise ECG be used to screen for sudden cardiac death?
Freeman, J., Ashley, E. A., & Froelicher, V. (2009). Should the exercise ECG be used to screen for sudden cardiac death?. EUROPEAN HEART JOURNAL, 30(5), 528-529.

Statin Use and Ventricular Arrhythmias During Clinical Treadmill Testing
Dewey, F. E., Perez, M., Hadley, D., Freeman, J. V., Wang, P., & Froelicher, V. F. (2009). Statin Use and Ventricular Arrhythmias During Clinical Treadmill Testing. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 20(2), 193-199.

A general framework for dose optimization.
Turcott, R. G., Sagreiya, H., Ashley, E. A., Altman, R. B., & Das, A. K. (2009). A general framework for dose optimization. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 2009, 656-660.

Age and Double Product (Systolic Blood Pressure x Heart Rate) Reserve-Adjusted Modification of the Duke Treadmill Score Nomogram in Men
Rafie, A. Hs., Dewey, F. E., Sungar, G. W., Ashley, E. A., Hadley, D., & Froelicher, V. F. (2008). Age and Double Product (Systolic Blood Pressure x Heart Rate) Reserve-Adjusted Modification of the Duke Treadmill Score Nomogram in Men. AMERICAN JOURNAL OF CARDIOLOGY, 102(10), 1407-1412.

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., & Quertermous, T. (2008). Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 118(10), 3343-3354.

Progressive dyspnea after CABG: Complication of retained epicardial pacing wires
Horng, G. S., Ashley, E., Balsam, L., Reitz, B., & Zamanian, R. T. (2008). Progressive dyspnea after CABG: Complication of retained epicardial pacing wires. ANNALS OF THORACIC SURGERY, 86(4), 1352-1354.

Low-dose growth hormone is cardioprotective in uremia
Rabkin, R., Awwad, I., Chen, Y., Ashley, E. A., Sun, D., & Gross, M.-L. (2008). Low-dose growth hormone is cardioprotective in uremia. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 19(9), 1774-1783.

Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels
Perez, M. V., Wheeler, M., Ho, M., Pavlovic, A., Wang, P., & Ashley, E. A. (2008). Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(2), 155-165.

Does size matter? Clinical applications of scaling cardiac size and function for body size
Dewey, F. E., Rosenthal, D., Murphy, D. J., Froelicher, V. F., & Ashley, E. A. (2008). Does size matter? Clinical applications of scaling cardiac size and function for body size. CIRCULATION, 117(17), 2279-2287.

Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics
Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25-36.

Ventricular arrhythmias during clinical treadmill testing and prognosis
Dewey, F. E., Kapoor, J. R., Williains, R. S., Lipinski, M. J., Ashley, E. A., & Froelicher, V. F. (2008). Ventricular arrhythmias during clinical treadmill testing and prognosis. ARCHIVES OF INTERNAL MEDICINE, 168(2), 225-234.

Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease
Hlatky, M. A., Ashley, E., Quertermous, T., Boothroyd, D. B., Ridker, P., & Go, A. S. (2007). Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. AMERICAN HEART JOURNAL, 154(6), 1043-1051.

Frontiers in nephrology: Genomic approaches to understanding the molecular basis of atherosclerosis
Ashley, E. A., Spin, J. M., Tabibiazar, R., & Quertermous, T. (2007). Frontiers in nephrology: Genomic approaches to understanding the molecular basis of atherosclerosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 18(11), 2853-2862.

Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse
Yue, P., Arai, T., Terashima, M., Sheikh, A. Y., Cao, F., & Tsao, P. S. (2007). Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 292(5), H2106-H2118.

Prognostic value of heart rate increase at onset of exercise testing
Leeper, N. J., Dewey, F. E., Ashley, E. A., Sandri, M., Tan, S. Y., & Froelicher, V. (2007). Prognostic value of heart rate increase at onset of exercise testing. CIRCULATION, 115(4), 468-474.

Emerging therapies for the management of decompensated heart failure - From bench to bedside
DeGoma, E. M., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2006). Emerging therapies for the management of decompensated heart failure - From bench to bedside. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(12), 2397-2409.

Network analysis of human in-stent restenosis
Ashley, E. A., Ferrara, R., King, J. Y., Vailaya, A., Kuchinsky, A., & Quertermous, T. (2006). Network analysis of human in-stent restenosis. CIRCULATION, 114(24), 2644-2654.

Opposing cardiovascular roles for the angiotensin and apelin signaling pathways
Ashley, E., Chun, H. J., & Quertermous, T. (2006). Opposing cardiovascular roles for the angiotensin and apelin signaling pathways. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 41(5), 778-781.

Perioperative cardiac risk: pathophysiology, assessment and management.
Sista, R. R., Ernst, K. V., & Ashley, E. A. (2006). Perioperative cardiac risk: pathophysiology, assessment and management. Expert review of cardiovascular therapy, 4(5), 731-743.

Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise
Ashley, E. A., Kardos, A., Jack, E. S., Habenbacher, W., Wheeler, M., & Douglas, P. (2006). Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(3), 523-531.

Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
Chong, K. S., Gardner, R. S., Morton, J. J., Ashley, E. A., & McDonagh, T. A. (2006). Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 8(4), 355-360.

Pathway analysis of coronary atherosclerosis
King, J. Y., Ferrara, R., Tabibiazar, R., Spin, J. M., Chen, M. M., & Ashley, E. A. (2005). Pathway analysis of coronary atherosclerosis. PHYSIOLOGICAL GENOMICS, 23(1), 103-118.

Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease
Tabibiazar, R., Wagner, R. A., Ashley, E. A., King, J. Y., Ferrara, R., & Quertermous, T. (2005). Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. PHYSIOLOGICAL GENOMICS, 22(2), 213-226.

Preoperative cardiac evaluation: mechanisms, assessment, and reduction of risk.
Ashley, E. A., & Vagelos, R. H. (2005). Preoperative cardiac evaluation: mechanisms, assessment, and reduction of risk. Thoracic surgery clinics, 15(2), 263-275.

Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease
Tabibiazar, R., Wagner, R. A., Spin, J. M., Ashley, E. A., Narasimhan, B., & Quertermous, T. (2005). Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25(2), 302-308.

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
Ashley, E. A., Powers, J., Chen, M., Kundu, R., Finsterbach, T., & Quertermous, T. (2005). The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. CARDIOVASCULAR RESEARCH, 65(1), 73-82.

Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation
Spin, J. M., Nallamshetty, S., Tabibiazar, R., Ashley, E. A., King, J. Y., & Quertermous, T. (2004). Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. PHYSIOLOGICAL GENOMICS, 19(3), 292-302.

Electrocardiographic arrhythmia risk testing
Engel, G., Beckerman, J. G., Froelicher, V. F., Yamazaki, T., Chen, H. A., & Wang, P. J. (2004). Electrocardiographic arrhythmia risk testing. CURRENT PROBLEMS IN CARDIOLOGY, 29(7), 365-432.

Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?
Sears, C. E., Ashley, E. A., & Casadei, B. (2004). Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 359(1446), 1021-1044.

Cardiology Explained
Ashley, E., Niebauer, & Josef. (2004). Cardiology Explained.

Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
Chen, M. M., Ashley, E. A., Deng, D. Xf., Tsalenko, A., Deng, A., & Quertermous, T. (2003). Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. CIRCULATION, 108(12), 1432-1439.

Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling
Sears, C. E., Bryant, S. M., Ashley, E. A., Lygate, C. A., Rakovic, S., & Casadei, B. (2003). Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling. CIRCULATION RESEARCH, 92(5), E52-E59.

Exercise testing scores as an example of better decisions through science
Ashley, E., Myers, J., & Froelicher, V. (2002). Exercise testing scores as an example of better decisions through science. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 34(8), 1391-1398.

Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
Ashley, E. A., Sears, C. E., Bryant, S. M., Watkins, H. C., & Casadei, B. (2002). Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes. CIRCULATION, 105(25), 3011-3016.

Diagnosing coronary artery disease in diabetic patients
Ashley, E. A., Raxwal, V., Finlay, M., & Froelicher, V. (2002). Diagnosing coronary artery disease in diabetic patients. DIABETES-METABOLISM RESEARCH AND REVIEWS, 18(3), 201-208.

Better decisions through science: Exercise testing scores
Froelicher, V., Shetler, K., & Ashley, E. (2002). Better decisions through science: Exercise testing scores. PROGRESS IN CARDIOVASCULAR DISEASES, 44(5), 395-414.

An evidence-based review of the resting electrocardiogram as a screening technique for heart disease
Ashley, E. A., Raxwal, V., & Froelicher, V. (2001). An evidence-based review of the resting electrocardiogram as a screening technique for heart disease. PROGRESS IN CARDIOVASCULAR DISEASES, 44(1), 55-67.

Sex, the heart, and sildenafil.
Alloggiamento, T., Zipp, C., Raxwal, V. K., Ashley, E., Dey, S., & Froelicher, V. F. (2001). Sex, the heart, and sildenafil. Current problems in cardiology, 26(6), 388-415.

The post myocardial infarction exercise test: still worthy after all of these years
Ashley, E. A., & Froelicher, V. (2001). The post myocardial infarction exercise test: still worthy after all of these years. EUROPEAN HEART JOURNAL, 22(4), 273-276.

Exercise testing in clinical medicine
Ashley, E. A., Myers, J., & Froelicher, V. (2000). Exercise testing in clinical medicine. LANCET, 356(9241), 1592-1597.

Computer applications in the interpretation of the exercise electrocardiogram
Ashley, E. A., & Froelicher, V. F. (2000). Computer applications in the interpretation of the exercise electrocardiogram. SPORTS MEDICINE, 30(4), 231-248.

Medical education - beyond tomorrow? The new doctor - Asclepiad or Logiatros?
Ashley, E. A. (2000). Medical education - beyond tomorrow? The new doctor - Asclepiad or Logiatros?. MEDICAL EDUCATION, 34(6), 455-459.

The prevalence and prognostic significance of electrocardiographic abnormalities
Ashley, E. A., Raxwal, V. K., & Froelicher, V. F. (2000). The prevalence and prognostic significance of electrocardiographic abnormalities. CURRENT PROBLEMS IN CARDIOLOGY, 25(1), 7-72.

The prevalence and prognostic significance of electrocardiographic abnormalities.
Ashley, E. A., Raxwal, V. K., & Froelicher, V. F. (2000). The prevalence and prognostic significance of electrocardiographic abnormalities. Current problems in cardiology, 25(1), 1-72.

Dangerous curves - A perspective on exercise, lactate, and the anaerobic threshold
Myers, J., & Ashley, E. (1997). Dangerous curves - A perspective on exercise, lactate, and the anaerobic threshold. CHEST, 111(3), 787-795.

Hormonal responses to graded-resistance, PES-assisted strength training in spinal cord-injured
Wheeler, G. D., Ashley, E. A., Harber, V., Laskin, J. J., OLENIK, L. M., & Cumming, D. C. (1996). Hormonal responses to graded-resistance, PES-assisted strength training in spinal cord-injured. SPINAL CORD, 34(5), 264-267.

EVIDENCE OF AUTONOMIC DYSREFLEXIA DURING FUNCTIONAL ELECTRICAL-STIMULATION IN INDIVIDUALS WITH SPINAL-CORD INJURIES
Ashley, E. A., Laskin, J. J., OLENIK, L. M., Burnham, R., Steadward, R. D., & Wheeler, G. D. (1993). EVIDENCE OF AUTONOMIC DYSREFLEXIA DURING FUNCTIONAL ELECTRICAL-STIMULATION IN INDIVIDUALS WITH SPINAL-CORD INJURIES. PARAPLEGIA, 31(9), 593-605.

ELECTRICAL STIMULATION-ASSISTED ROWING EXERCISE IN SPINAL-CORD INJURED PEOPLE - A PILOT-STUDY
Laskin, J. J., Ashley, E. A., OLENIK, L. M., Burnham, R., Cumming, D. C., & Wheeler, G. D. (1993). ELECTRICAL STIMULATION-ASSISTED ROWING EXERCISE IN SPINAL-CORD INJURED PEOPLE - A PILOT-STUDY. PARAPLEGIA, 31(8), 534-541.